Para-terphenyl compounds

ABSTRACT

The present invention provides a selective suppressor of the IgE production comprising a compound which suppresses the IgE production in a process from a differentiation of a mature B cell into an antibody-producing cell to the production of an antibody and which does not suppress or weakly suppresses the production of IgG, IgM and/or IgA which are produced at the same time, a compound of the formula (I): 
                         
wherein R 1 –R 13  are hydrogen, halogen, lower alkyl, lower alkoxy or the like, X is —O—, —CH 2 —, —NR 14 — or —S(O)p- and Y is lower alkyl, lower alkenyl or the like, a process for producing the same and a pharmaceutical composition comprising the same.

This application is a Divisional of co-pending application Ser. No. 09/214,277 filed on Mar. 1, 1999 and for which priority is claimed under 35 U.S.C. § 120. application Ser. No. 09/214,277 is the national phase of PCT International Application No. PCT/JP97/02635 filed on Jul. 30, 1997 under 35 U.S.C. § 371. The entire contents of each of the above-identified applications are hereby incorporated by reference. This application also claims priority of Application No. 8-201859, 8-287782 and 9-86085 filed in Japan on Jul. 31, 1996, Oct. 30, 1996 and Mar. 18, 1997, respectively under 35 U.S.C. § 119.

TECHNICAL FIELD

The present invention relates to a novel para-terphenyl compound, a process for producing the same, a selective suppressor of the IgE production, an immunosuppressor and an anti-allergic agent.

BACKGROUND ART

A serious problem of a transplantation of a tissue or an organ which is frequently performed in recent years is a rejection symptom for excluding a transplanted part after an operation. Prevention of the rejection symptom is very important for a success of the transplantation.

Various immunosuppressors such as azathioprine, corticoid, Cyclosporin A, Tacrolimus and the like are developed and come into practical use for prevention and a treatment of a rejection symptom against a transplantation of an organ or a tissue or a graft-versus-host reaction which is caused by a bone marrow transplantation. But they are not so satisfactory in view of their effects and side effects.

Allergic diseases such as atopic dermatitis, allergic rhinitis, bronchial asthma, allergic conjunctivitis and the like globally tend to increase in recent years and become serious problems. The conventional antiinflammatory agents are suppressors of releasing chemical mediators from mast cells, receptor inhibitors of the chemical mediators released, suppressors of allergic inflammation reaction or the like. All of these are agents for symptomatic therapy and are not fundamental therapeutic agents for allergic diseases.

As an fundamental therapeutic agent for allergic diseases, a suppressor of the IgE antibody production has been expected.

One of compounds which have a suppressive effect on the IgE production is Suplatast Tosilate (IPD-1151-T). This is reported to act on T cell of type 2 (Th2 cell) to suppress the IL-4 production and to suppress a differentiation of B cells to IgE antibody-producing cells (Jpn. Pharmacol. (1993) 61, 31–39).

As compounds which directly act on B cells to suppress the IgE antibody production, for example, DSCG (Intal) or Nedcromil sodium which are degranulation inhibitors of mast cells are exemplified. These are reported to inhibit a class-switch of B cells (J. Exp. Med. (1994) 180: 663–671, J. Allergy Clin. Immunol. (1996) 97: 1141–1150). In J. Med. Chem. (1997) 40: 395–407, a compound which directly acts on B cells to suppress the IgE production is described.

Because immune globulins are necessary for phylaxis and a suppression of immune globulins other than IgE antibody is not preferable, an inhibitor which has a high selectivity to IgE and a potent effect has been desired.

The compounds which have an antiinflammatory effect and ortho-terphenyl structure are described in JP-A 60-13730, J. Med. Chem. (1996) 39: 1846–1856 and WO96/10012, and the compounds which have the same effect and biphenyl structure are described in JP-B 43-19935, JP-A 62-294650 and WO96/18606.

The compounds which have para-terphenyl structure are described in Chemical & Pharmaceutical Bulletin, 24 (4), 613–620 (1976), The Journal of Antibiotics, 32 (6), 559–564 (1979) and Agricultural Biological Chemistry, 49 (3), 867–868 (1985) but an immunosuppressive or antiinflammatory effect of these compounds is not described at all.

DISCLOSURE INVENTION

An object of the present invention is to provide a selective suppressor of the IgE production, an immunosuppressor, and/or an anti-allergic agent which has a potent suppressive effect on the IgE production, an immunosuppressive effect and/or an anti-allergic effect. Other object of the present invention is to provide novel compounds which have the above effects and a process for producing the same.

The present invention provides a selective suppressor of the IgE production, an immunosuppressor and/or an anti-allergic agent comprising a compound which suppresses the IgE production in a process from a differentiation of a mature B cell into an antibody-producing cell to the production of an antibody and which does not suppress or weakly sup presses the production of IgG, IgM and/or IgA which are produced at the same time. The present invention provides a method for selectively suppressing the IgE production or for suppressing an immune reaction or a method for treating and/or preventing allergic diseases comprising administering the compound. In another embodiment, the present invention provides use of the compound for the manufacture of a medicament for selectively suppressing the IgE production, suppressing the immune reaction or treating and/or preventing allergic diseases.

The present invention provides a compound of the formula (I) as an example of the compounds which has the above effects:

-   wherein R¹, R², R³, R⁴, R⁵, R⁶, R⁷, R⁸, R⁹, R¹⁰, R¹¹, R¹² and R¹³     are each independently hydrogen, hydroxy, halogen, carboxy,     optionally substituted lower alkyl, optionally substituted lower     alkoxy, optionally substituted lower alkenyl, optionally substituted     lower alkenyloxy, optionally substituted lower alkylthio, optionally     substituted lower alkoxycarbonyl, optionally substituted acyloxy,     optionally substituted lower alkylsulfonyl, optionally substituted     lower alkylsulfonyloxy, optionally substituted lower alkylsulfinyl,     nitro, cyano, formyl, optionally substituted amino, optionally     substituted carbamoyl, optionally substituted sulfamoyl or     optionally substituted heterocyclyl, -   X is —O—, —CH₂—, —NR¹⁴— wherein R¹⁴ is hydrogen, optionally     substituted lower alkyl, optionally substituted lower alkenyl or     acetyl, or —S(O)p- wherein p is an integer of 0 to 2, -   Y is optionally substituted lower alkyl, optionally substituted     lower alkenyl, optionally substituted lower alkynyl, optionally     substituted acyl, optionally substituted cycloalkyl, optionally     substituted cycloalkenyl, optionally substituted aryl or optionally     substituted heterocyclyl, and Y may optionally be substituted lower     alkoxy when X is —CH₂— and may optionally be substituted lower     alkoxycarbonyl, optionally substituted lower alkylsulfonyl or     optionally substituted arylsulfonyl when X is —O— or —NR¹⁴—, -   R¹ and R⁴, R¹ and R², R² and R³, R⁴ and R⁵, R⁶ and R⁷, R⁸ and R⁹, R⁸     and R⁹, R¹⁰ and R¹¹, R¹² and R¹³, R¹¹ and —X—Y, or R¹³ and —X—Y     taken together may form a 5- or 6-membered ring which may contain     one or more of O, S or NR¹⁵ wherein R¹⁵ is hydrogen, optionally     substituted lower alkyl, optionally substituted lower alkenyl,     optionally substituted arylsulfonyl and which may optionally be     substituted, -   excluding compounds wherein one or more of R⁶, R⁷, R⁸ and R⁹ are     halogen and the others are hydrogen, all of R⁶, R⁷, R⁸ and R⁹ are     halogen and all of R²–R¹³ are hydrogen, halogen or cyano, -   provided that R¹ is not hydrogen, fluorine, optionally substituted     lower alkyl or optionally substituted lower alkoxy, all of R², R³,     R⁴, R⁵ and R¹² are hydrogen, or R¹³ is not hydrogen or halogen when     R⁶, R⁷, R⁸ and R⁹ are all simultaneously hydrogen, and further     provided that R¹ is not methyl or acetyloxy, R¹³ is not hydrogen,     optionally substituted lower alkoxycarbonyl or optionally     substituted carbamoyl, or —X—Y is not methoxy when at least one of     R⁶, R⁷, R⁸ and R⁹ is a substituent other than hydrogen, and     excluding a compound of the formula (I′):

wherein R^(1′) is hydrogen or hydroxy and R^(13′) is hydroxy or methoxy, pharmaceutically acceptable salt, hydrate or prodrug thereof.

The present invention provides a pharmaceutical composition, more specifically a selective suppressor of the IgE production, an immunosuppressor or an anti-allergic agent, comprising the compound (I), pharmaceutically acceptable salt, hydrate or prodrug thereof.

The present invention provides a selective suppressor of the IgE production, an immunosuppressor and/or an anti-allergic agent comprising a compound of the formula (I″):

wherein R¹, R², R³, R⁴, R⁵, R⁶, R⁷, R⁸, R⁹, R¹⁰, R¹¹, R¹² and R¹³ are each independently hydrogen, hydroxy, halogen, carboxy, optionally substituted lower alkyl, optionally substituted lower alkoxy, optionally substituted lower alkenyl, optionally substituted lower alkenyloxy, optionally substituted lower alkylthio, optionally substituted lower alkoxycarbonyl, optionally substituted acyloxy, optionally substituted lower alkylsulfonyl, optionally substituted lower alkylsulfonyloxy, optionally substituted lower alkylsulfinyl, nitro, cyano, formyl, optionally substituted amino, optionally substituted carbamoyl, optionally substituted sulfamoyl or optionally substituted heterocyclyl,

-   X is —O—, —CH₂—, —NR¹⁴— wherein R¹⁴ is hydrogen, optionally     substituted lower alkyl, optionally substituted lower alkenyl or     acetyl, or —S(O)p- wherein p is an integer of 0 to 2, -   Y is optionally substituted lower alkyl, optionally substituted     lower alkenyl, optionally substituted lower alkynyl, optionally     substituted acyl, optionally substituted cycloalkyl, optionally     substituted cycloalkenyl, optionally substituted aryl or optionally     substituted heterocyclyl, and Y may optionally be substituted lower     alkoxy when X is —CH₂— and may optionally be substituted lower     alkoxycarbonyl, optionally substituted lower alkylsulfonyl or     optionally substituted arylsulfonyl when X is —O— or —NR¹⁴—, -   R¹ and R⁴, R¹ and R², R² and R³, R⁴ and R⁵, R⁶ and R⁷, R⁸ and R⁹,     R¹⁰ and R¹¹, R¹² and R¹³, R¹¹ and —X—Y, or R¹³ and —X—Y taken     together may form a 5- or 6-membered ring which may contain one or     more of O, S or NR¹⁵ wherein R¹⁵ is hydrogen, optionally substituted     lower alkyl, optionally substituted lower alkenyl or optionally     substituted arylsulfonyl and which may optionally be substituted,     excluding a compound of the formula (I′):

wherein R^(1′) is hydrogen or hydroxy and R^(13′) is hydroxy or methoxy, pharmaceutically acceptable salt, hydrate or prodrug thereof.

The present invention provides a method for selectively suppressing the IgE production, suppressing an immune reaction or treating or preventing allergic diseases comprising administering the compound (I) or (I″). In another embodiment, the present invention provides use of the compound (I) or (I″) for manufacturing of a medicament for selectively suppressing the IgE production, suppressing the immune reaction or treating or preventing allergic diseases.

In one of the other embodiments, the present invention provides a process for producing a compound of the formula (I′″):

the compound of the above formula (I) or (I′), pharmaceutically acceptable salt or hydrate thereof

-   wherein R¹, R², R³, R⁴, R⁵, R⁶, R⁷, R⁸, R⁹, R¹⁰, R¹¹, R¹² and R¹³     are each independently hydrogen, hydroxy, halogen, carboxy,     optionally substituted lower alkyl, optionally substituted lower     alkoxy, optionally substituted lower alkenyl, optionally substituted     lower alkenyloxy, optionally substituted lower alkylthio, optionally     substituted lower alkoxycarbonyl, optionally substituted acyloxy,     optionally substituted lower alkylsulfonyl, optionally substituted     lower alkylsulfonyloxy, optionally substituted lower alkylsulfinyl,     nitro, cyano, formyl, optionally substituted amino, optionally     substituted carbamoyl, optionally substituted sulfamoyl or     optionally substituted heterocyclyl, -   X is —O—, —CH₉—, —NR¹⁴— wherein R¹⁴ is hydrogen, optionally     substituted lower alkyl, optionally substituted lower alkenyl or     acetyl, or —S(o)p- wherein p is an integer of 0 to 2, -   Y is optionally substituted lower alkyl, optionally substituted     lower alkenyl, optionally substituted lower alkynyl, optionally     substituted acyl, optionally substituted cycloalkyl, optionally     substituted cycloalkenyl, optionally substituted aryl or optionally     substituted heterocyclyl, and Y may optionally be substituted lower     alkoxy when X is —CH₂— and may optionally be substituted lower     alkoxycarbonyl, optionally substituted lower alkylsulfonyl or     optionally substituted arylsulfonyl when X is —O— or —NR¹⁴—, -   R¹ and R⁴, R¹ and R², R² and R³, R⁴ and R⁵, R⁶ and R⁷, R⁸ and R⁹,     R¹⁰ and R¹¹, R¹² and R¹³, R¹¹ and —X—Y, or R¹³ and —X—Y taken     together may form a 5- or 6-membered ring which may contain one or     more of 0, S or NR¹⁵ wherein R¹⁵ is hydrogen, optionally substituted     lower alkyl, optionally substituted lower alkenyl, optionally     substituted arylsulfonyl, and which may optionally be substituted, -   excluding a compound wherein one or more of R⁶, R⁷, R⁸ and R⁹ are     halogen and the others are hydrogen, all of R⁶, R⁷, R⁸ and R⁹ are     halogen and all of R²–R¹³ are hydrogen, halogen or cyano, -   provided that R¹ is not hydrogen, fluorine; optionally substituted     lower alkyl or optionally substituted lower alkoxy, all of R², R³,     R⁴, R⁵ and R¹² are hydrogen or R¹³ is not hydrogen or halogen when     R⁶, R⁷, R⁸ and R⁹ are all simultaneously hydrogen, and further     provided that R¹ is not methyl or acetyloxy, R¹³ is not hydrogen,     optionally substituted lower alkoxycarbonyl or optionally     substituted carbamoyl or —X—Y is not methoxy when at least one of     R⁶, R⁷, R⁸ and R⁹ is a substituent other than hydrogen,     pharmaceutically acceptable salt or hydrate thereof, which comprises     reacting a compound of the formula (II):

with a compound of the formula (III):

wherein, in the formulas (II) and (III), R¹–R¹³, X and Y are the same as defined in the above formula (I), either of A and Z is dihydroxyborane, di(lower)alkoxyborane, di(lower)alkylborane,

and the other is halogen or —OSO₂(C_(q)F_(2q+1))— wherein q is an integer of 0 to 4, or reacting a compound of the formula (II′):

with a compound of the formula (III′):

wherein, in the formulas (II′) and (III′), R¹–R¹³, X and Y are the same as defined in the above formula (I) and A and Z are the same as defined in the above formulas (II) and (III). As another process, the present invention provides a process for producing the compound of the above formula (I′″), (I) or (I′), pharmaceutically acceptable salt or hydrate thereof comprising the reaction of a compound of the formula (IV):

with a compound of the formula (V):

wherein, in the formulas (IV) and (V), R¹–R⁹ are the same as defined in the above formula (I), Z¹ is the same as Z defined in the above formula (II), A¹ and A² are each independently the same as A defined in the above formula (III) and the reactivity of A¹ is higher than or equal to that of A², followed by the reaction with a compound of the formula (VI):

wherein R¹⁰–R¹³, X and Y are the same as defined in the above formula (I) and Z² is the same as Z defined in the above formula (II) and a process for producing the compound of the above formula (I′″), (I) or (I′), pharmaceutically acceptable salt, hydrate thereof comprising the reaction of a compound of the formula (IV′):

wherein R⁶–R⁹ is the same as defined in the above formula (I), A¹ and A² are each independently the same as A defined in the above formula (III) and the reactivity of A² is higher than or equal to that of A¹, with a compound of the above formula (VI), followed by the reaction with a compound of the above formula (V).

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 shows an antibody production-suppressive effect on human peripheral lymphocytes of the compound (I-839) of the present invention. The ordinate represents a percentage of the amount of antibodies to that of antibodies which are produced in the absence of the compound. The abscissa represents a concentration of the compound.

FIG. 2 shows an antibody production-suppressive effect on human peripheral lymphocytes of the compound No. 36. The ordinate represents a percentage of the amount of antibodies to that of antibodies which are produced in the absence of the compound. The abscissa represents a concentration of the compound.

FIG. 3 shows an antibody production-suppressive effect on mouse spleen lymphocytes of the compound (I-967) of the present invention. The ordinate represents a percentage of the amount of antibodies to that of antibodies which are produced in the absence of the compound. The abscissa represents a concentration of the compound.

FIG. 4 shows a suppressive effect of the compound (I-963) of the present invention for an infiltration of inflammatory cells to irrigation water of pulmonary alveolus by an antigen stimulation on mice. The ordinate represents the number of inflammatory cells and the abscissa represents the number of total inflammatory cells, the number of macrophages, the number of eosinophils and the number of neutrophils. The white column represents a group inhaling saline instead of ovalbumin, the black column represents a group inhaling an antigen to cause inflammation and without administration of any compound of the present invention, and the gray column represents a group inhaling an antigen to cause inflammation with administration of the compound of the present invention.

BEST MODE FOR CARRYING OUT THE INVENTION

In the present specification, the term “halogen” includes fluorine, chlorine, bromine and iodine. Fluorine or chlorine is preferable. The halogen in the term “halogeno(lower)alkyl”, “halogeno(lower)alkenyl” and “halogenoaryl” is the same as above.

The term “lower alkyl” represents straight or branched chain alkyl having 1 to 10 carbon atoms, preferably 1 to 8 carbon atoms, more preferably 1 to 6 carbon atoms and most preferably 1 to 4 carbon atoms. For example, included are methyl, ethyl, n-propyl, isopropyl, n-butyl, isobutyl, sec-butyl, tert-butyl, n-pentyl, isopentyl, neopentyl, hexyl, isohexyl, n-heptyl, isoheptyl, n-octyl, isooctyl, n-nonyl, n-decyl and the like.

As substituents of the “optionally substituted lower alkyl” in R¹–R¹³, R¹⁴ and R¹⁵ exemplified are halogen; hydroxy; lower alkoxy optionally substituted with lower alkoxy; carboxy; lower alkoxycarbonyl; acyloxy and the like and the lower alkyl may be substituted with one or more of these substituents at any possible positions.

As substituents for “optionally substituted lower alkyl” in Y exemplified are halogen; hydroxy; carboxy; lower alkoxycarbonyl; lower alkoxy optionally substituted with lower alkoxy; acyl; acyloxy; amino optionally substituted with hydroxy or lower alkyl; imino optionally substituted with hydroxy, lower alkoxy, carboxy(lower)alkoxy, aryl(lower)alkoxy or heterocyclyl; hydrazono optionally substituted with carbamoyl or lower alkoxycarbonyl; cycloalkyl optionally substituted with lower alkyl; cycloalkenyl optionally substituted with lower alkyl; cyano; carbamoyl optionally substituted with lower alkyl or amino; thiocarbamoyl optionally substituted with lower alkyl;

wherein ring A represents cycloalkyl or heterocyclyl;

-   aryl optionally substituted with lower alkyl, halogeno(lower)alkyl,     carboxy(lower)alkyl, lower alkoxycarbonyl(lower)alkyl, halogen,     hydroxy, lower alkoxy, carboxy, lower alkoxycarbonyl, lower     alkenyloxycarbonyl, acyloxy, nitro, cyano, amino, lower     alkoxycarbonylamino, acylamino, lower alkylsulfonylamino, lower     alkylamino or guanidino; or -   heterocyclyl optionally substituted with lower alkyl (optionally     substituted with heterocyclyl), halogen, hydroxy, carboxy, lower     alkoxycarbonyl, lower alkylsulfonyl, lower alkylarylsulfonyl,     mercapto, lower alkylthio or heterocyclyl optionally substituted     with aryl.

The alkyl part of “halogeno(lower)alkyl”, “hydroxy(lower)alkyl”, “carboxy(lower)alkyl”, “lower alkoxycarbonyl(lower)alkyl”, “lower alkylthio”, “lower alkylamino”, “lower alkylsulfonyl”, “lower alkylsulfonyloxy”, “lower alkylsulfonylamino”, “lower alkylsulfinyl”, “lower alkylaryl”, “lower alkylarylsulfonyl”, “di(lower)alkylcarbamoyl”, “di(lower)alkylborane”, “lower alkoxy”, “carboxy(lower)alkoxy”, “aryl(lower)alkoxy”, “lower alkoxy(lower)alkoxy”, “lower alkoxyaryl” or “di(lower)alkoxyborane” is the same as defined in the above “lower alkyl”. As substituents in the case of being “optionally substituted” exemplified are halogen; hydroxy; lower alkoxy; carboxy; lower alkoxycarbonyl; acyloxy; cycloalkyl; aryl optionally substituted with lower alkyl; heterocyclyl and the like. These substituents may substitute at one or more of any possible positions.

The part of lower alkyl in “lower alkoxycarbonyl” is the same as the above defined “lower alkyl” and substituents for “optionally substituted lower alkoxycarbonyl” are the same as those for the above “optionally substituted lower alkoxy”.

The part of “lower alkoxycarbonyl” in “lower alkoxycarbonyl(lower)alkyl”, “lower alkoxycarbonyl(lower)alkenyl” or “lower alkoxycarbonylamino” is the same as the above defined “lower alkoxycarbonyl”.

The term “lower alkenyl” represents straight or branched chain alkenyl having 2 to 10 carbon atoms, preferably 2 to 8 carbon atoms and more preferably 3 to 6 carbon atoms. For example, included are vinyl, propenyl, isopropenyl, butenyl, isobutenyl, butadienyl, pentenyl, isopentenyl, pentadienyl, hexenyl, isohexenyl, hexadienyl, heptenyl, octenyl, nonenyl, decenyl and the like and these have one or more double bonds at any possible positions. Substituents for “optionally substituted lower alkenyl” are the same as that for the above “optionally substituted lower alkoxy”.

The part of lower alkenyl in “lower alkoxycarbonyl(lower)alkenyl”, “halogeno(lower)alkenyl”, “lower alkenyloxy”, “lower alkenyloxycarbonyl” or “lower alkenylamino” is the same as the above defined “lower alkenyl”.

Substituents for “optionally substituted lower alkenyloxy” are the same as those for the above “optionally substituted lower alkoxy”.

The term “lower alkynyl” represents straight or branched chain alkynyl having 2 to 10 carbon atoms, preferably 2 to 8 carbon atoms and more preferably 3 to 8 carbon atoms. Specifically, included are ethynyl, propynyl, butynyl, pentynyl, hexynyl, heptynyl, octynyl, nonyl, decynyl and the like. These have one or more triple bonds at any possible positions and may further have a double bond. Substituents for “optionally substituted lower alkynyl” are the same as those for the above “optionally substituted lower alkoxy”.

The term “acyl” represents aliphatic acyl which includes chain acyl having 1 to 10 carbon atoms, preferably 1 to 8 carbon atoms, more preferably 1 to 6 carbon atoms, most preferably 1 to 4 carbon atoms and cyclic acyl having 3 to 8 carbon atoms, preferably 3 to 6 carbon atoms, and aroyl. Specifically, included are formyl, acetyl, propionyl, butyryl, isobutyryl, valeryl, pivaloyl, hexanoyl, acryloyl, propioloyl, methacryloyl, crotonoyl, cyclohexanecarbonyl, benzoyl and the like. Substituents for “optionally substituted acyl” are the same as those for “optionally substituted lower alkoxy” and aroyl may further be substituted with lower alkyl.

The part of acyl in “acyloxy” or “acylamino” is the same as the above identified “acyl” and substituents for “optionally substituted acyloxy” are the same as those for the above “optionally substituted acyl”.

The term “cycloalkyl” represent cyclic hydrocarbon having 3 to 6 carbon atoms and includes, for example, cyclopropyl, cyclobutyl, cyclopentyl cyclohexyl and the like. As substituents for “optionally substituted cycloalkyl” exemplified are lower alkyl, halogen, hydroxy, carboxy, lower alkoxycarbonyl, lower alkoxy, aryl, heterocyclyl and the like and the cycloalkyl may be substituted at any possible positions.

The term “cycloalkenyl” represents the group having one or more double bonds at any possible positions in the above cycloalkyl and included are, for example, cyclopropenyl, cyclobutenyl, cyclopentenyl, cyclohexenyl, cyclohexadienyl and the like. Substituents for “optionally substituted cycloalkenyl” are the same as those for the above identified “cycloalkyl”.

The term “optionally substituted amino” includes substituted amino and unsubstituted amino and substituents exemplified are lower alkyl optionally substituted with lower alkylaryl etc.; lower alkenyl optionally substituted with halogen; lower alkylsulfonyl; lower alkylarylsulfonyl; lower alkoxycarbonyl; sulfamoyl; acyl optionally substituted with halogen; carbamoyl and the like.

The term “optionally substituted carbamoyl” includes substituted carbamoyl and unsubstituted carbamoyl and substituents exemplified are lower alkyl; lower alkylsulfonyl; sulfamoyl; acyl optionally substituted with halogen; amino and the like.

The term “optionally substituted sulfamoyl” includes substituted sulfamoyl and unsubstituted sulfamoyl and substituents exemplified are lower alkyl optionally substituted with aryl; lower alkenyl and the like.

The term “aryl” includes phenyl, naphthyl, anthryl, indenyl, phenanthryl and the like. Substituents for “optionally substituted aryl” exemplified are lower alkyl optionally substituted with halogen or carboxy; hydroxy; halogen; lower alkoxy; lower acyloxy; carboxy; lower alkoxycarbonyl; lower alkenyloxycarbonyl; amino optionally substituted with lower alkyl, lower alkylsulfonyl, lower alkoxycarbonyl or acyl; guanidino; nitro; aryl; heterocyclyl and the like and “optionally substituted aryl” may be substituted with one or more of these substituents at any possible positions.

The part of aryl in “lower alkylaryl”, “halogenoaryl”, “lower alkoxyaryl”, “arylsulfonyl”, “aryl(lower)alkoxy”, “lower alkylarylsulfonyl”, “heterocyclyl substituted with aryl”, “aroyl” or “aroyloxy” is the same as the above “aryl” and the substituents for “optionally substituted” are also the same as those for in the above “optionally substituted aryl”.

The term “heterocyclyl” represents a heterocyclic group which contains one or more of hetero atoms arbitrarily selected from a group of O, S and N and exemplified are 5- or 6-membered aromatic heterocyclyl such as pyrrolyl, imidazolyl, pyrazolyl, pyridyl, pyridazinyl, pyrimidinyl, pyrazinyl, triazolyl, triazinyl, isoxazolyl, oxazolyl, oxadiazolyl, isothiazolyl, thiazolyl, thiaziazolyl, furyl, thienyl etc., condensed aromatic heterocyclyl such as indolyl, carbazolyl, acridinyl, benzimidazolyl, indazolyl, indolizinyl, quinolyl, isoquinolyl, cinnolinyl, phthalazinyl, quinazolinyl, naphthyridinyl, quinoxalinyl, purinyl, pteridinyl, benzisoxazolyl, benzoxazolyl, benzoxadiazolyl, benzisothiazolyl, benzothiazolyl, benzothiaziazolyl, benzofuryl, benzothienyl, benzotriazolyl etc., and alicyclic heterocyclyl such as dioxanyl, thiiranyl, oxiranyl, oxathioranyl, azetidinyl, thianyl, pyrrolidinyl, pyrrolinyl, imidazolidinyl, imidazolinyl, pyrazolidinyl, pyrazolinyl, piperidyl, piperazinyl, morpholinyl etc. As substituents for “optionally substituted heterocyclyl” exemplified are lower alkyl, lower alkenyl, hydroxy, halogen, carboxy, lower alkoxycarbonyl, lower alkoxy, mercapto, lower alkylthio, lower alkylsulfonyl, aryl, heterocyclyl and the like and the heterocyclyl may be substituted with one or more of these substituents at any possible positions. The part of heterocycle in “heterocyclyl substituted with aryl” is the same as the above “heterocyclyl”.

The term “5- or 6-membered ring which may contain one or more of 0, S or NR¹⁵ and may optionally be substituted” represents a 5- or 6-membered ring which is formed by R¹ and R⁴, R¹ and R², R² and R³, R⁴ and R⁵, R⁶ and R⁷, R⁸ and R⁹, R¹⁰ and R¹¹, R¹² and R¹³, R¹¹ and —X—Y, or R¹³ and —X—Y with the two carbon atoms constituting phenyl to which the above substituents are attached. For example, the above substituents taken together form —(CH₂)₃—, —(CH₂)₄—, —O(CH₂)_(m)O—, —O(CH₂)_(n)—, —(CH₂)_(n)O—, —S(CH₂)_(m)S—, —S(CH₂)_(n)—, —(CH₂)_(n)S—, —NR¹⁵(CH₂)_(m)NR¹⁵, —NR¹⁵(CH₂)_(n)—, —(CH₂)_(n)NR¹⁵—, —O(CH₂)_(m)S—, —S(CH₂)_(m)O—, —S(CH₂)_(m)NR¹⁵, —NR¹⁵(CH₂)_(m)S—, —O(CH₂)_(m)NR¹⁵—, —NR¹⁵(CH₂)_(m)O—, —O—CH═CH—, —CH═CH—O—, —S—CH═CH—, —CH═CH—S—, —NR¹⁵—CH═CH—, —CH═CH—NR¹⁵—, —S—CH═N—, —N═CH—S—, —S—N═CH—, —CH═N—S—, —O—CH═N—, —N═CH—O—, —O—N═CH—, —CH═N—O—, —NR¹⁵—CH═N—, —N═CH—NR¹⁵—, —NR¹⁵—N═CH—, —CH═N—NR¹⁵—, —N═CH—CH═CH—, —CH═CH—CH═N—, —N═N—CH═CH—, —CH═CH—N═N—, —N═CH—N═CH—, —CH═N—CH═N—, —N═CH—CH═N— (m is 1 or 2 and n is 2 or 3) or the like and further these and the two carbon atoms constituting phenyl taken together form a 5- or 6-membered ring. These rings may be substituted with one or more of hydroxy; halogen; lower alkyl optionally substituted with lower alkoxycarbonyl or heterocyclyl; lower alkenyl optionally substituted with halogen; lower alkyliden optionally substituted with halogen; or the like. The substituents of “5- or 6-membered ring which may contain one or more of 0 or NR¹⁵ and may optionally be substituted”, “5- or 6-membered ring which contains one or more of 0 or NR¹⁵ and may optionally be substituted” and “5- or 6-membered ring which contains one or more of 0 and may optionally be substituted” are the same as the above unless otherwise defined.

The term “lower alkylidene” represents straight or branched alkylidene having 1 to 6 carbon atoms, preferably 1 to 4 carbon atoms, more preferably 1 to 3 carbon atoms and includes, for example, methylene, ethylidene, isopropylidene, vinylidene, methylidyne and the like.

The term “all of R²–R¹³ are hydrogen, halogen or cyano” represents, for example, the case that R²–R¹³ are the same or different and hydrogen, halogen or cyano. For example, included are the case that all of R²–R¹³ are hydrogen, the case that all of them are halogen, the case that some are halogen and the others are hydrogen, the case that some are cyano and the others are hydrogen, the case that some are halogen, some are cyano and the others are hydrogen and the like.

The term “compound (I)”, “compound (I″)” or “compound (I′″)” also includes formable and pharmaceutically acceptable salts of each compounds. As “the pharmaceutically acceptable salt”, exemplified are salts with mineral acid such as hydrochloric acid, sulfuric acid, nitric acid, phosphoric acid, hydrofluoric acid, hydrobromic acid and the like; salts with organic acids such as formic acid, acetic acid, tartaric acid, lactic acid, citric acid, fumaric acid, maleic acid, succinic acid and the like; salts with organic bases such as ammonium, trimethylammonium, triethylammonium and the like; salts with alkaline metals such as sodium, potassium and the like and salts with alkaline earth metals such as calcium, magnesium and the like.

The compound of the present invention includes hydrates and all of stereoisomers, for example, atropisomers etc. thereof.

The compound of the present invention includes prodrugs thereof. The term “prodrug” means a group of compounds which are easily changeable to the compounds (I) or (I″) which have activities in living bodies. The prodrug may be prepared by usual reactions. As usual methods for producing prodrugs exemplified is the substitution of hydroxy by acyloxy substituted with carboxy, sulfo, amino, lower alkylamino or the like, phosphonoxy or the like. The substitution of hydroxy attached to R¹ by —OCOCH₂CH₂COOH, —OCOCH═CHCOOH, —OCOCH₂SO₃H, —OPO₃H₂, —OCOCH₂NMe₂, —OCO-Pyr (Pyr is pyridine) or the like is preferable.

In the present specification, the term “compound (I)” represents a group comprising novel compounds excluding the compound (I′), the term “compound (I″)” represents a group comprising the compound (I) and known compounds and the term “compound (I′″)” represents a group comprising the compound (I) and the compound (I′).

All of the compounds (I) and (I″) have a suppressive effect on the IgE production, an immunosuppressive effect and/or an anti-allergic effect and the following compounds are specifically preferable.

In the formulas (I) and (I″),

-   1) a compound wherein R¹, R², R³, R⁴, R⁵, R⁶, R⁷, R⁸, R⁹, R¹⁰, R¹¹,     R¹² and R¹³ are each independently hydrogen, hydroxy, halogen,     carboxy, optionally substituted lower alkyl, optionally substituted     lower alkoxy, optionally substituted lower alkenyl, optionally     substituted lower alkenyloxy, optionally substituted lower     alkylthio, optionally substituted lower alkoxycarbonyl, optionally     substituted acyloxy, optionally substituted lower alkylsulfonyloxy,     formyl, optionally substituted amino, optionally substituted     carbamoyl or optionally substituted sulfamoyl, -   X is —O—, —CH₂—, —NR¹⁴— wherein R¹⁴ is hydrogen or optionally     substituted lower alkyl, or —S(O)p- wherein p is an integer of 0 to     2, -   Y is optionally substituted lower alkyl, optionally substituted     lower alkenyl, optionally substituted lower alkynyl, optionally     substituted acyl or optionally substituted cycloalkenyl, and -   R¹ and R⁴, R¹ and R², R⁸ and R⁹, R¹¹ and —X—Y, or R¹³ and —X—Y taken     together may form a 5- or 6-membered ring which may contain one or     more of O or NR¹⁵, -   2) a compound wherein R¹ is hydrogen, hydroxy, halogen, carboxy,     optionally substituted lower alkyl, optionally substituted lower     alkoxy, optionally substituted lower alkenyloxy, optionally     substituted lower alkylthio, optionally substituted lower     alkoxycarbonyl, optionally substituted lower alkylsulfonyloxy, lower     alkylsulfonyl, formyl, optionally substituted amino, lower     alkylsulfinyl, acyloxy, nitro, cyano, optionally substituted     sulfamoyl or heterocyclyl, -   R² is hydrogen, hydroxy, halogen, optionally substituted lower alkyl     or optionally substituted lower alkylsulfonyloxy, -   R³ is hydrogen, hydroxy, halogen or optionally substituted lower     alkoxy, -   R⁴ is hydrogen, optionally substituted lower alkyl, halogen,     optionally substituted lower alkoxy, nitro or optionally substituted     amino, -   R⁵ is hydrogen, optionally substituted lower alkoxy, lower     alkoxycarbonyl or carboxy, -   R⁶ is hydrogen, halogen, optionally substituted lower alkyl,     carboxy, lower alkoxycarbonyl, nitro, formyl, amino or lower     alkylsulfonyloxy, -   R⁷ and R⁸ are each independently hydrogen, halogen, optionally     substituted lower alkyl, optionally substituted lower alkoxy, formyl     or optionally substituted amino, -   R⁹ is hydrogen, hydroxy, carboxy, optionally substituted lower     alkyl, optionally substituted lower alkoxy, optionally substituted     lower alkenyl, optionally substituted lower alkoxycarbonyl,     optionally substituted lower alkylsulfonyloxy, formyl, optionally     substituted carbamoyl or optionally substituted amino, -   R¹⁰ is hydrogen or lower alkoxy, -   R¹¹ is hydrogen, halogen, optionally substituted lower alkyl,     carboxy, lower alkoxycarbonyl, optionally substituted lower     alkylsulfonyloxy, formyl, nitro or amino, -   R¹² is hydrogen, -   R¹³ is hydroxy, halogen, carboxy, optionally substituted lower     alkyl, optionally substituted lower alkoxy, optionally substituted     lower alkenyloxy, optionally substituted acyloxy, optionally     substituted lower alkylsulfonyloxy, formyl, nitro or optionally     substituted amino, and further R¹³ may be hydrogen in the formula     (I″), -   Y is optionally substituted lower alkyl, optionally substituted     lower alkenyl, optionally substituted lower alkynyl, optionally     substituted acyl or optionally substituted cycloalkenyl and Y may be     optionally substituted lower alkoxycarbonyl, optionally substituted     lower alkylsulfonyl or optionally substituted arylsulfonyl when X is     —O— or —NR¹⁴—, and -   R¹ and R², R¹ and R⁴, R⁸ and R⁹, R¹¹ and —X—Y, or R¹³ and —X—Y taken     together may form a 5- or 6-membered ring which contains one or more     of O or NR¹⁵ wherein R¹⁵ is the same as defined above and which may     optionally be substituted, -   3) a compound wherein R¹ is hydrogen, hydroxy, halogen, carboxy,     optionally substituted lower alkyl, optionally substituted lower     alkoxy, optionally substituted lower alkenyloxy, optionally     substituted lower alkylthio, optionally substituted lower     alkoxycarbonyl, optionally substituted lower alkylsulfonyloxy, lower     alkylsulfonyl, formyl, optionally substituted amino, lower     alkylsulfinyl, acyloxy, nitro, cyano, optionally substituted     sulfamoyl or heterocyclyl (hereinafter referred to as “R¹ is R1-1”)     or R¹ and R² or R⁴ taken together form a 5- or 6-membered ring which     contains one or more of O or NR¹⁵ wherein R¹⁵ is the same as defined     above and which may optionally be substituted, -   preferably R¹ is hydrogen, hydroxy, halogen, optionally substituted     lower alkoxy, optionally substituted lower alkenyloxy, optionally     substituted lower alkylsulfonyloxy, optionally substituted amino,     optionally substituted sulfamoyl (hereinafter referred to as -   “R¹ is R1-2”), or R¹ and R² or R⁴ taken together form a 5- or     6-membered ring which contains one or more of O or NR¹⁵ wherein R¹⁵     is the same as defined above and which may optionally be     substituted, -   more preferably, R¹ is hydrogen, hydroxy, halogen, lower     alkoxy(lower)alkoxy, aryl(lower)alkoxy, lower alkenyloxy, lower     alkylsulfonyloxy, amino, lower alkylamino or lower alkenylamino     (hereinafter referred to as “R¹ is R1-3”), or R¹ and R² or R⁴ taken     together form a 5- or 6-membered ring which contains one or more of     O or NR¹⁵ wherein R¹⁵ is the same as defined above and which may     optionally be substituted, most preferably, R¹ is hydrogen, hydroxy,     chlorine, fluorine, methoxymethyloxy, benzyloxy,     3-methyl-2-butenyloxy, methanesulfonyloxy, amino, dimethylamino or     3-methyl-2-butenylamino (hereinafter referred to as “R¹ is R1-4”),     or R¹ and R² or R⁴ taken together form —OCH₂O— or —CH═CH—NH—, -   4) a compound wherein R² is hydrogen, hydroxy, halogen, lower alkyl     or optionally substituted lower alkylsulfonyloxy (hereinafter     referred to as “R² is R2-1”) or R¹ and R² taken together form a 5-     or 6-membered ring which contains one or more of O or NR¹⁵ wherein     R¹⁵ is the same as defined above and which may optionally be     substituted, preferably R² is hydrogen, halogen or alkyl having 1 to     3 carbon atoms (hereinafter referred to as “R² is R2-2”), -   5) a compound wherein R³ is hydrogen, hydroxy, halogen or optionally     substituted lower alkoxy (hereinafter referred to as “R³ is R3-1”),     preferably R³ is hydrogen or halogen (hereinafter referred to as “R³     is R3-2”), more preferably R³ is hydrogen or fluorine (hereinafter     referred to as “R³ is R3-3”), -   6) a compound wherein R⁴ is hydrogen, optionally substituted lower     alkyl, halogen, optionally substituted lower alkoxy, nitro or     optionally substituted amino (hereinafter referred to as “R⁴ is     R4-1”) or R⁴ and R¹ taken together may form a 5- or 6-membered ring     which contains one or more of O or NR¹⁵ wherein R¹⁵ is the same as     defined above and which may optionally be substituted, -   preferably R⁴ is hydrogen, lower alkyl, lower alkoxy or halogen     (hereinafter referred to as “R⁴ is R4-2”), or R⁴ and R¹ taken     together may form —OCH₂O—, -   7) a compound wherein R⁵ is hydrogen, optionally substituted lower     alkoxy, lower alkoxycarbonyl or carboxy (hereinafter referred to as     “R⁵ is R5-1”), preferably R⁵ is hydrogen, lower alkoxycarbonyl or     carboxy (hereinafter referred to as “R⁵ is R5-2”), more preferably     R⁵ is hydrogen (hereinafter referred to as “R⁵ is R5-3”), -   8) a compound wherein R⁶ is hydrogen, halogen, optionally     substituted lower alkyl, carboxy, lower alkoxycarbonyl, nitro,     formyl, amino or lower alkylsulfonyloxy (hereinafter referred to as     “R⁶ is R6-1”), -   preferably R⁶ is hydrogen or lower alkyl or halogen (hereinafter     referred to as “R⁶ is R6-2”), -   more preferably R⁶ is hydrogen, alkyl having 1 to 3 carbon atoms or     halogen (hereinafter referred to as “R⁶ is R6-3”), -   9) a compound wherein R⁷ is hydrogen, halogen, optionally     substituted lower alkyl, optionally substituted lower alkoxy, formyl     or optionally substituted amino (hereinafter referred to as “R⁷ is     R7-1”), -   preferably R⁷ is hydrogen, lower alkyl or lower alkoxy (hereinafter     referred to as “R⁷ is R7-9”), -   10) a compound wherein R⁸ is hydrogen, halogen, optionally     substituted lower alkyl, optionally substituted lower alkoxy, formyl     or optionally substituted amino (hereinafter referred to as “R⁸ is     R8-1”) or R⁸ and R⁹ taken together may form a 5- or 6-membered ring     which contains one or more of O and which may optionally be     substituted, preferably R⁸ is hydrogen, lower alkyl or lower alkoxy     (hereinafter referred to as “R⁸ is R8-2”), -   11) a compound wherein R⁹ is hydrogen, hydroxy, carboxy, optionally     substituted lower alkyl, optionally substituted lower alkoxy,     optionally substituted lower alkenyl, optionally substituted lower     alkoxycarbonyl, optionally substituted lower alkylsulfonyloxy,     formyl, optionally substituted carbamoyl or optionally substituted     amino (hereinafter referred to as “R⁹ is R9-1”) or R⁹ and R⁸ taken     together may form a 5- or 6-membered ring which contains one or more     of O and which may optionally be substituted, -   preferably R⁹ is hydrogen, hydroxy, carboxy, optionally substituted     lower alkyl, optionally substituted lower alkoxy, optionally     substituted lower alkenyl, optionally substituted lower     alkoxycarbonyl, optionally substituted lower alkylsulfonyloxy,     formyl, optionally substituted carbamoyl or optionally substituted     amino (hereinafter referred to as “R⁹ is R9-2”), -   more preferably R⁹ is hydrogen, hydroxy, lower alkyl,     hydroxy(lower)alkyl, lower alkoxycarbonyl(lower)alkenyl, lower     alkoxy(lower)alkoxy, lower alkylsulfonyloxy,     di(lower)alkylcarbamoyl, carboxy, lower alkoxycarbonyl or amino     (hereinafter referred to as “R⁹ is R9-3”), -   most preferably R⁹ is hydrogen, hydroxy, methyl, hydroxymethyl,     ethoxycarbonylvinyl, methoxymethyloxy, methanesulfonyl,     dimethylcarbamoyl, carboxy, methoxycarbonyl or amino (hereinafter     referred to as “R⁹ is R9-4”), -   12) a compound wherein R¹⁰ is hydrogen or lower alkoxy (hereinafter     referred to as “R¹⁰ is R10-1”), preferably R¹⁰ is hydrogen     (hereinafter referred to as “R¹⁰ is R10-2”), -   13) a compound wherein RI¹ is hydrogen, halogen, optionally     substituted lower alkyl, carboxy, lower alkoxycarbonyl, optionally     substituted lower alkylsulfonyloxy, formyl, nitro or amino     (hereinafter referred to as “R¹¹ is R11-1”) or R¹¹ and —X—Y taken     together form a 5- or 6-membered ring which contains one or more of     O or NR¹⁵ wherein R¹⁵ is the same as defined above and which may     optionally be substituted with lower alkenyl, halogeno(lower)alkenyl     or the like, -   preferably R¹¹ is hydrogen or halogen (hereinafter referred to as     “R¹¹ is R11-2”), -   14) a compound wherein R¹² is hydrogen, -   15) a compound wherein R¹³ is hydrogen, hydroxy, halogen, carboxy,     optionally substituted lower alkyl, optionally substituted lower     alkoxy, optionally substituted lower alkenyloxy, optionally     substituted acyloxy, optionally substituted lower alkylsulfonyloxy,     formyl, nitro or optionally substituted amino (hereinafter referred     to as “R¹³ is R13-1”) or R¹³ and —X—Y taken together form a 5- or     6-membered ring which contains one or more of O or NR¹⁵ wherein R¹⁵     is the same as defined above and which may optionally be substituted     with lower alkenyl, halogeno(lower)alkenyl or the like, -   preferably R¹³ is hydrogen, hydroxy, halogen, carboxy, optionally     substituted lower alkyl, optionally substituted lower alkoxy,     optionally substituted acyloxy, optionally substituted lower     alkylsulfonyloxy, formyl or optionally substituted amino     (hereinafter referred to as “R¹³ is R13-2”), -   more preferably R¹³ is hydroxy; halogen; lower alkyl optionally     substituted with hydroxy or halogen; lower alkoxy optionally     substituted with lower alkoxycarbonyl or lower alkoxy; lower     alkenyloxy optionally substituted with halogen; aroyloxyl; lower     alkylsulfonyloxy; formyl or amino (hereinafter referred to as “R¹³     is R13-3”), most preferably R¹³ is hydroxy, fluorine, methyl,     hydroxymethyl, iodomethyl, methoxy, ethoxy, isopropyloxy,     ethoxycarbonylmethyloxy, methoxymethyloxy, chlorobutenyloxy,     bromopropenyloxy, chloropropenyloxy, bromobutenyloxy,     dichloropropenyloxy, ethoxycarbonyl, benzoyloxy, methanesulfonyloxy,     formyl or amino (hereinafter referred to as “R¹³ is R13-4”), -   16) a compound wherein X is —O—, —NR¹⁴— or —S(O)p- wherein p is an     integer of 0 to 2 (hereinafter referred to as “X is X1”), or X, R¹³     and Y taken together may form a 5- or 6-membered ring which contains     one or more of O or NR¹⁵ wherein R¹⁵ is the same as defined above     and may optionally be substituted, -   preferably X is —O—, —NH—, —NMe— or —SO₂— (hereinafter referred to     as “X is X2”), more preferably X is —O—, —NH—or —NMe— (hereinafter     referred to as “X is X3”), most preferably X is —O—, -   17) a compound wherein Y is optionally substituted lower alkyl,     optionally substituted lower alkenyl, optionally substituted lower     alkynyl, optionally substituted cycloalkenyl, lower alkylsulfonyl,     optionally substituted arylsulfonyl, lower alkoxycarbonyl or     optionally substituted acyl (hereinafter referred to as “Y is Y1”),     or Y, R¹³ and X taken together may form a 5- or 6-membered ring     which contains one or more of O or NR¹⁵ wherein R¹⁵ is the same as     defined above and which may optionally be substituted, preferably Y     is lower alkyl optionally substituted with halogen; hydroxy; amino     optionally substituted with lower alkyl; lower alkoxy; carboxy;     lower alkoxycarbonyl; acyl; cycloalkyl; cycloalkenyl; cyano; imino     optionally substituted with hydroxy, lower alkoxy,     carboxy(lower)alkoxy, aryl(lower)alkoxy or heterocyclyl; hydrazono     optionally substituted with carbamoyl or lower alkoxycarbonyl;     carbamoyl optionally substituted with lower alkyl or amino;     thiocarbamoyl optionally substituted with lower alkyl; aryl     optionally substituted with amino (optionally substituted with lower     alkyl, acyl, lower alkoxycarbonyl or lower alkylsulfonyl), nitro,     acyloxy, lower alkyl (optionally substituted with halogen or     carboxy), halogen, lower alkoxy, carboxy, lower alkoxycarbonyl,     lower alkenyloxycarbonyl or guanidino; or heterocyclyl optionally     substituted with halogen or lower alkyl; lower alkenyl optionally     substituted with halogen, hydroxy, cycloalkyl, lower alkoxycarbonyl     or aryl-substituted heterocyclyl; lower alkynyl optionally     substituted with halogen; or cycloalkenyl (hereinafter referred to     as “Y is Y2”), -   more preferably Y is lower alkyl optionally substituted with lower     alkoxycarbonyl, aryl, lower alkylaryl, halogenoaryl, lower     alkoxyaryl, heterocyclyl or acyl; or lower alkenyl optionally     substituted with hydroxy, halogen or aryl (hereinafter referred to     as “Y is Y3”), -   most preferably Y is isopropyl, ethoxycarbonylmethyl, benzyl,     methylphenylmethyl, fluorophenylmethyl, dichlorophenylmethyl,     methoxyphenylmethyl, pyridylmethyl, benzoylmethyl, propenyl,     methylpropenyl, methylbutenyl, hydroxymethylbutenyl, pentenyl,     methylpentenyl, dimethyloctadienyl, chloropropenyl,     dichloropropenyl, bromopropenyl, dibromopropenyl, fluoropropenyl,     difluoropropenyl, butenyl, bromobutenyl, chlorobutenyl or     phenylpropenyl (hereinafter referred to as “Y is Y4”), -   18) a compound wherein R¹ is R1-2, R² is R2-1, R³ is R3-1, R⁴ is     R4-1, R⁵ is R5-1, R⁶ is R6-1, R⁷ is R7-1, R⁸ is R8-1, R⁹ is R9-2,     R¹⁰ is R10-1, R¹¹ is R11-1, R¹² is hydrogen, R¹³ is R13-1, X is X1     and Y is Y1, and R¹ and R², R¹ and R⁴, R⁸ and R⁹, or R¹³ and —X—Y     taken together may form a 5- or 6-membered ring which contains one     or more of O or NR¹⁵ wherein R¹⁵ is the same as defined above and     which may optionally be substituted, -   19) a compound wherein R¹ is R1-2, R² is R2-1, R³ is R3-1, R⁴ is     R4-1, R⁵ is R5-1, R⁶ is R6-1, R⁷ is R7-1, R⁸ is R8-1, R⁹ is R9-1,     R¹⁰ is R10-1, R¹¹ is R11-1, R¹² is hydrogen R¹³ is R13-2, X is X1     and Y is Y1, and R¹ and R², R¹ and R⁴, R⁸ and R⁹, or R¹³ and —X—Y     taken together may form a 5- or 6-membered ring which contains one     or more of O or NR¹⁵ wherein R¹⁵ is the same as defined above and     which may optionally be substituted, -   20) a compound wherein R¹ is R1-2, R² is R2-1, R³ is R3-1, R⁴ is     R4-1, R⁵ is R5-1, R⁶ is R6-2, R⁷ is R7-2, R⁸ is R8-2, R⁹ is R9-1,     R¹⁰ is R10-1, R¹¹ is R11-1, R¹² is hydrogen R¹³ is R13-1, X is X1     and Y is Y2, and R1 and R², R¹ and R⁴, R⁸ and R⁹, or R¹³ and —X—Y     taken together may form a 5- or 6-membered ring which contains one     or more of O or NR¹⁵ wherein R¹⁵ is the same as defined above and     which may optionally be substituted, -   21) a compound wherein R¹ is R1-1, R² is R2-1, R³ is R3-1, R⁴ is     R4-1, R⁵ is R5-1, R⁶ is R6-2, R⁷ is R7-1, R⁸ is R8-2, R⁹ is R9-2,     R¹⁰ is R10-1, R¹¹ is R11-1, R¹² is hydrogen, R¹³ is R13-2, X is X1     and Y is Y1, and R¹ and R², R¹ and R⁴, R⁸ and R⁹, or R¹³ and —X—Y     taken together may form a 5- or 6-membered ring which contains one     or more of O or NR¹⁵ wherein R¹⁵ is the same as defined above and     which may optionally be substituted, -   22) a compound wherein R¹ is R1-1, R² is R2-1, R³ is R3-1, R⁴ is     R4-1, R⁵ is R5-1, R⁶ is R6-2, R⁷ is R7-1, R⁸ is R8-2, R⁹ is R9-2,     R¹⁰ is R10-1, R¹¹ is R11-1, R¹² is hydrogen, R¹³ is R13-1, X is X1     and Y is Y2, and R¹ and R², R¹ and R⁴, R⁸ and R⁹, or R¹³ and —X—Y     taken together may form a 5- or 6-membered ring which contains one     or more of O or NR¹⁵ wherein R¹⁵ is the same as defined above and     which may optionally be substituted, -   23) a compound wherein R¹ is R1-1, R² is R2-1, R³ is R3-1, R⁴ is     R4-1, R⁵ is R5-1, R⁶ is R6-2, R7 is R7-1, R⁸ is R8-2, R⁹ is R9-1,     R¹⁰ is R10-1, R¹¹ is R11-1, R¹² and hydrogen, R¹³ is R13-2, X is X1     and Y is Y2, and R¹ and R², R¹ and R⁴, R⁸ and R⁹ or R¹³ and —X—Y     taken together may form a 5- or 6-membered ring which contains one     or more of O or NR¹⁵ wherein R¹⁵ is the same as defined above and     which may optionally be substituted, -   24) a compound wherein R¹ is R1-2, R² is R2-1, R³ is R3-1, R⁴ is     R4-1, R⁵ is R5-1, R⁶ is R6-2, R⁷ is R7-1, R⁸ is R8-2, R⁹ is R9-2,     R¹⁰ is R10-1, R¹¹ is R11-1, R¹² is hydrogen, R¹³ is R13-2, X is X1     and Y is Y1, and R¹ and R², R¹ and R⁴, R⁸ and R⁹, or R¹³ and —X—Y     taken together may form a 5- or 6-membered ring which contains one     or more of O or NR¹⁵ wherein R¹⁵ is the same as defined above and     which may optionally be substituted, -   25) a compound wherein R¹ is R1-2, R² is R2-1, R³ is R3-1, R⁴ is     R4-1, R⁵ is R5-1, R⁶ is R6-2, R⁷ is R7-1, R⁸ is R8-2, R⁹ is R9-2,     R¹⁰ is R10-1, R¹¹ is R11-1, R¹² is hydrogen, R¹³ is R13-1, X is X1     and Y is Y2, and R¹ and R², R¹ and R⁴, R⁸ and R⁹, or R¹³ and —X—Y     taken together may form a 5- or 6-membered ring which contains one     or more of O or NR¹⁵ wherein R¹⁵ is the same as defined above and     which may optionally be substituted, -   26) a compound wherein R¹ is R1-2, R² is R2-1, R³ is R3-1, R⁴ is     R4-1, R⁵ is R5-1, R⁶ is R6-2, R⁷ is R7-1, R⁸ is R8-2, R⁹ is R9-1,     R¹⁰ is R10-1, R¹¹ is R11-1, R¹² is hydrogen, R¹³ is R13-2, X is X1     and Y is Y2, and R¹ and R², R¹ and R⁴, R8 and R⁹, or R¹³ and —X—Y     taken together may form a 5- or 6-membered ring which contains one     or more of O or NR¹⁵ wherein R¹⁵ is the same as defined above and     which may optionally be substituted, -   27) a compound wherein R¹ is R1-1, R² is R2-1, R³ is R3-1, R⁴ is     R4-1, R⁵ is R5-1, R⁶ is R6-2, R⁷ is R7-1, R⁸ is R8-2, R⁹ is R9-2,     R¹⁰ is R10-1, R¹¹ is R11-1, R¹² is hydrogen, R¹³ is R13-2, X is X1     and Y is Y2, and R¹ and R², R¹ and R⁴, R⁸ and R⁹, or R¹³ and —X—Y     taken together may form a 5- or 6-membered ring which contains one     or more of O or NR¹⁵ wherein R¹⁵ is the same as defined above and     which may optionally be substituted, -   28) a compound wherein R¹ is R1-2, R² is R2-2, R³ is R3-2, R⁴ is     R4-2, R⁵ is R5-2, R⁶ is R6-2, R⁷ is R7-2, R⁸ is R8-2, R⁹ is R9-2,     R¹⁰ is R10-2, R¹² is hydrogen, R¹³ is R13-2, X is X2 and Y is Y2,     and R¹ and R⁴, or R⁸ and R⁹ taken together may form a 5- or     6-membered ring which contains one or more of O, -   29) a compound wherein R¹ is R1-3, R² is R2-2, R³ is R3-2, R⁴ is     R4-2, R⁵ is R5-2, R⁶ is R6-2, R⁷ is R7-2, R⁸ is R8-2, R⁹ is R9-2,     R¹⁰ is R10-2, R¹ and R⁴, or R⁸ and R⁹ taken together may form a 5-     or 6-membered ring which contains one or more of O, -   30) a compound wherein R¹ is R1-4, R² is R2-2, R³ is R3-2, R⁴ is     R4-2, R⁵ is R5-2, R⁶ is R6-2, R⁷ is R7-2, R⁸ is R8-2, R⁹ is R9-2,     R¹⁰ is R10-2, R¹¹ is R11-2, R¹² is hydrogen, R¹³ is R13-2, X is X2     and Y is Y2, and R¹ and R⁴, or R⁸ and R⁹ taken together may form     —OCH₂O—, -   31) a compound wherein R¹ is R1-2, R² is R2-2, R³ is R3-2, R⁴ is     R4-2, R⁵ is R5-2, R⁶ is R6-2, R⁷ is R7-2, R⁸ is R8-2, R⁹ is R9-3,     R¹⁰ is R10-2, R¹² is hydrogen, R¹³ is R13-2, X is X2 and Y is Y2,     and R¹ and R⁴, or R⁸ and R⁹ taken together may form a 5- or     6-membered ring which contains one or more of O, -   32) a compound wherein R1 is R1-2, R² is R2-2, R³ is R3-2, R⁴ is     R4-2, R⁵ is R5-2, R⁶ is R6-2, R⁷ is R7-2, R⁸ is R8-2, R⁹ is R9-4,     R¹⁰ is R10-2, R¹¹ is R11-2, R¹² is hydrogen, R¹³ is R13-2, X is X2     and Y is Y2, and R¹ and R⁴, or R⁸ and R⁹ taken together may form a     5- or 6-membered ring which contains one or more of O, -   33) a compound wherein R¹ is R1-2, R² is R2-2, R³ is R3-2, R⁴ is     R4-2, R⁵ is R5-2, R⁶ is R6-2, R⁷ is R7-2, R⁸ is R8-2, R⁹ is R9-2,     R¹⁰ is R11-2, R¹² is hydrogen, R¹³ is R13-3, X is X2 and Y is Y2,     and R¹ and R⁴, or R⁸ and R⁹ taken together may form a 5- or     6-membered ring which contains one or more of O, -   34) a compound wherein R¹ is R1-2, R² is R2-2, R³ is R3-2, R⁴ is     R4-2, R⁵ is R5-2, R⁶ is R6-2, R⁷ is R7-2, R⁸ is R8-2, R⁹ is R9-2,     R¹⁰ is R10-2, R¹¹ is R11-2, R¹² is hydrogen, R¹³ is R13-4, X is X2     and Y is Y2, and R¹ and R⁴, or R⁸ and R⁹ taken together may form a     5- or 6-membered ring which contains one or more of O, -   35) a compound wherein R¹ is R1-2, R² is R2-2, R³ is R3-2, R⁴ is     R4-2, R⁵ is R5-2, R⁶ is R6-2, R⁷ is R7-2, R⁸ is R8-2, R⁹ is R9-2,     R¹⁰ is R10-2, R¹¹ us R11-2, R¹² is hydrogen, R¹³ is R13-2, X is X2     and Y is Y3, and R¹ and R⁴, or R⁸ and R⁹ taken together may form a     5- or 6-membered ring which contains one or more of O, -   36) a compound wherein R¹ is R1-3, R² is R2-2, R³ is R3-2, R⁴ is     R4-2, R⁵ is R5-2, R⁶ is R6-2, R⁷ is R7-2, R⁸ is R8-2, R⁹ is R9-3,     R¹⁰ is R10-2, R¹¹ is R11-2, R¹² is hydrogen, R¹³ is R13-2, X is X2     and Y is Y2, and R¹ and R⁴, or R⁸ and R⁹ taken together may form a     5- or 6-membered ring which contains one or more of O, -   37) a compound wherein R¹ is R1-3, R² is R2-2, R3 is R3-2, R⁴ is     R4-2, R⁵ is R5-2, R⁶ is R6-2, R⁷ is R7-2, R⁸ is R8-2, R⁹ is R9-2,     R¹⁰ is R10-2, R¹¹ is R11-2, R¹² is hydrogen, R¹³ is R13-3, X is X2     and Y is Y2, and R¹ and R⁴, or R⁸ and R⁹ taken together may form a     5- or 6-membered ring which contains one or more of O, -   38) a compound wherein R¹ is R1-3, R² is R2-2, R³ is R3-2, R⁴ is     R4-2, R⁵ is R5-2, R⁶ is R6-2, R⁷ is R7-2, R⁸ is R8-2, R⁹ is R9-2,     R¹⁰ is R10-2, R¹¹ is R11-2, R¹² is hydrogen, R¹³ is R13-2, X is X2     and Y is Y3, and R¹ and R⁴, or R⁸ and R⁹ taken together may form a     5- or 6-membered ring which contains one or more of O, -   39) a compound wherein R¹ is R1-2, R² is R2-2, R³ is R3-2, R⁴ is     R4-2, R⁵ is R5-1, R⁶ is R6-2, R⁷ is R7-2, R⁸ is R8-2, R⁹ is R9-3,     R¹⁰ is R10-2, R¹¹ is R11-2, R¹² is hydrogen, R¹³ is R13-3, X is X2     and Y is Y2, and R¹ and R⁴, or R⁸ and R⁹ taken together may form a     5- or 6-membered ring which contains one or more of O, -   40) a compound wherein R¹ is R1-2, R² is R2-2, R³ is R3-2, R⁴ is     R4-2, R⁵ is R5-2, R⁶ is R6-3, R⁷ is R7-2, R⁸ is R8-2, R⁹ is R9-3,     R¹⁰ is R10-2, R¹¹ is R11-2, R¹² is hydrogen, R¹³ is R13-2, X is X2     and Y is Y3, and R¹ and R⁴, or R⁸ and R⁹ taken together may form a     5- or 6-membered ring which contains one or more of O, -   41) a compound wherein R¹ is R1-2, R² is R2-2, R³ is R3-2, R⁴ is     R4-2, R⁵ is R5-2, is R6-2, R⁷ is R7-2, R⁸ is R8-2, R⁹ is R9-2, R¹⁰     is R10-2, R¹¹ is R11-2, R¹² is hydrogen, R¹³ is R13-3, X is X2 and Y     is Y3, and R¹ and R⁴, or R⁸ and R⁹ taken together may form a 5- or     6-membered ring which contains one or more of O, -   42) a compound wherein R¹ is R1-3, R² is R2-2, R³ is R3-2, R⁴ is     R4-2, R⁵ is R5-2, R⁶ is R6-2, R⁷ is R7-2, R⁸ is R8-2, R⁹ is R9-3,     R¹⁰ is R10-2, R¹¹ is R10-2, R¹² is hydrogen, R¹³ is R13-3, X is X2     and Y is Y2, and R¹ and R⁴, or R⁸ and R⁹ taken together may form     —OCH₂O—, -   43) a compound wherein R¹ is R1-3, R² is R2-2, R³ is R3-2, R⁴ is     R4-2, R⁵ is R5-2, R⁶ is R6-2, R⁷ is R7-2, R⁸ is R8-2, R⁹ is R9-3,     R¹⁰ is R10-2, R¹¹ is R11-2, R¹² is hydrogen, R¹³ is R13-2, X is X2     and Y is Y3, and R¹ and R⁴, or R⁸ and R⁹ taken together may form     —OCH₂O—, -   44) a compound wherein R¹ is R1-3, R² is R2-2, R³ is R3-3, R⁴ is     R4-2, R⁵ is R5-2, R⁶ is R6-2, R⁷ is R7-2, R⁸ is R8-2, R⁹ is R9-2,     R¹⁰ is R10-2, is R¹¹ is R11 -2, R¹² is hydrogen, R¹³ is R13-3, X is     X2 and Y is Y3, and R¹ and R⁴, or R⁸ and R⁹ taken together may form     —OCH₂O—, -   45) a compound wherein R¹ is R1-2, R² is R2-2, R³ is R3-3, R⁴ is     R4-2, R⁵ is R5-3, R⁶ is R6-2, R⁷ is R7-2, R⁸ is R8-2, R⁹ is R9-3,     R¹⁰ is R10-2, R¹¹ is R11-2, R¹² is hydrogen, R¹³ is R13-3, X is X2     and Y is Y3, and R¹ and R⁴, or R⁸ and R⁹ taken together may form a     5- or 6-membered ring which contain one or more of O, -   46) a compound wherein R¹ is R1-3, R² is R2-2, R³ is R3-3, R⁴ is     R4-2, R⁵ is R5-1, R⁶ is R6-3, R⁷ is R7-2, R⁸ is R8-2, R⁹ is R9-3,     R¹⁰ is R10-2, R¹¹ is R11-2, R¹² is hydrogen, R¹³ is R13-3, X is X3     and Y is Y4, and R¹ and R⁴, or R⁸ and R⁹ taken together may form     —OCH₂O—, -   47) a compound wherein R¹ is R1-4, R² is R2-2, R³ is R3-3, R⁴ is     R4-2, R⁵ is R5-3, R⁶ is R6-3, R⁷ is R7-2, R⁸ is R8-2, R⁹ is R9-4,     R¹⁰ is R10-2, R¹¹ is R11-2, R¹² is hydrogen, R¹³ is R13-4, X is X3     and Y is Y4, RI and R⁴ taken together may form —OCH₂O— and R⁸ and R⁹     taken together may form —OCH₂CH₂O—, -   48) a compound wherein the benzene ring which is substituted with     R¹–R⁵ is

-   49) a compound wherein the benzene ring which is substituted with     R⁶–R⁹ is

-   50) a compound wherein the benzene ring which is substituted with     R¹⁰–R¹³ is

-   51) a compound wherein Y is —CH₂CH═CMe₂, —(CH₂)₂CH═CMe₂,     —CH₂CH═CCl₂, —CH₂CH═CBr₂, —CH₂CH═CF₂, —CH₂CH═CHMe,     —CH₂CH═C(Me)CH₂OH, —CH₂C≡CMe, —CH₂C₆H₄-4-Me, —CH₂C₆H₅, —CH₂CH₂CHMe₂     or —Me, -   52) a compound wherein —X—Y is —OCH₂CH═CMe₂, —O(CH₂)₂CH═CMe₂,     —OCH₂CH═CCl₂, —OCH₂CH═CBr₂, —OCH₂CH═CF₂, —OCH₂C≡CMe, —OCH₂C₆H₄-4-Me,     —OCH₂C₆H₅, —NHCH₂CH═CMe₂, —N(Me)CH₂CH═CMe₂, —NHCH₂CH₂CHMe₂,     —NHCH₂C≡CH, or —NMe₂, or -   53) a compound wherein at least seven of the substituents of R¹–R¹³     are hydrogen, preferably at least eight are hydrogen, more     preferably at least nine are hydrogen, and their pharmaceutically     acceptable salts, their hydrates and their prodrugs.

A process for producing the compound (I′″) is as follows.

Process for Producing the Compound (I′″) [Process a]

The compound (I′″) can be produced by the reaction of a borane compound of the formula (II) and (II′) coupled with a biphenyl derivative of the formula (III) and (III′) respectively, as shown below.

wherein R¹–R¹³, X and Y are the same as defined in the above formula (I′″), and A and Z are the same as defined in the above formulas (II) and (III), or

wherein R¹–R¹³, X and Y are the same as defined in the above formula (I′″), and A and Z are the same as defined in the above formulas (II) and (III).

The compounds (II) and (II′) are reacted with the compounds (III) and (III′) respectively in a mixture system of an appropriate solvent such as benzene, toluene, dimethylformamide, dimethoxyethane, tetrahydrofuran, dioxane, ethanol, methanol or the like and water or in an anhydrous system in the presence of a palladium catalyst such as Pd(PPh₃)₄, PdCl₂(PPh₃)₂, PdCl₂(OAc)₂, PdCl₂(CH₃CN)₂ or the like, Pd(PPh₃)₄, under a basic condition (for example, by K₃PO₄, NaHCO₃, NaOEt, Na₂CO₃, Et₄NCl, Ba(OH)₂, Cs₂CO₃, CsF, NaOH, Ag₂CO₃ or the like) at room temperature or with heating for several tens minutes to several tens hours to obtain the compound (I′″).

One of substituents A and Z of the compounds to be reacted may be any of the borane groups which are applicable in the Suzuki Reaction (Chemical Communication 1979, 866, Journal of Synthetic Organic Chemistry, Japan, 1993, Vol. 51, No. 11, 91–100) and dihydroxyborane is preferable. The other may be any of the leaving groups which are applicable in the Suzuki Reaction, for example, halogen, —OSO₂(C_(q)F_(2q+1)) wherein q is an integer of 0 to 4, or the like. Specifically, halogen, trifluoromethanesulfonyloxy (hereinafter referred to as OTf) or the like is preferable and bromine, iodine or OTf is more preferable.

The substituents R¹–R¹³ and —X—Y of the compounds (II), (III), (II′) and (III′) may be any of the groups which do not affect the Suzuki Reaction, for example, any groups other than halogen and —OSO₂(C_(q)F_(2q+)1) wherein q is an integer of 0 to 4.

For example, Y may be optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkynyl, optionally substituted acyl, optionally substituted cycloalkyl, optionally substituted cycloalkenyl, optionally substituted aryl or optionally substituted heterocyclyl, Y may be optionally substituted lower alkoxy when X is —CH₂— and Y may be optionally substituted lower alkoxycarbonyl, optionally substituted lower alkylsulfonyl or optionally substituted arylsulfonyl when X is —O— or —NR14—. Even if R¹–R¹³ or Y is halogen, these reactions can be carried out without difficulty when the reactivity of the substituent A with the substituent Z is higher than that of halogen with either of substituents A and Z.

Even if one of R¹–R¹³ and —X—Y is hydroxy, the above reactions can be carried out preferably after the protection of hydroxy group with a usual hydroxy-protecting group (for example, metoxymethyl, benzyl, tert-butyldimethylsilyl, methansulfonyl, p-toluenesulfonyl or the like), followed by the removal of them by usual methods.

As processes for producing the compound (I′″), the above mentioned Suzuki Reaction is most preferable in view of the efficiency and easiness but silicon, zinc, tin or the like can be used in place of the borane group in the above scheme.

For example, in the case that one of A and Z is —SiR¹⁷ _(3-r)(Hal)_(r) wherein R¹⁷ is independently lower alkyl, Hal is halogen and r is an integer of 1 to 3 and the other is halogen or —OSO₂(C_(q)F_(2q+1)) wherein q is an integer of 0 to 4, the coupling reaction may be carried out using a usual palladium catalyst (Synlett (1991) 845–853, J. Org. Chem. 1996, 61, 7232–7233). Examples of preferable palladium catalysts are (i-Pr₃P)₂PdCl₂, [(dcpe)PdCl₂](dcpe=Cy₂PCH₂CH₂PCy₂), (η³—C₃H₅PdCl)₂ and the like.

Even in the case that one of A and Z is —SnR¹⁸ ₃ wherein R¹⁸ is each independently lower alkyl and the other is halogen, acetyloxy or —OSO₂(C_(q)F_(2q+1)) wherein q is an integer of 0 to 4, an objective compound can be obtained using a usual palladium catalyst (preferably Pd(PPh₃)₄ or the like) (Angew. Chem. Int. Ed. Engl. 25 (1986) 508–524).

In the case that one of A and Z is —Zn(Hal) wherein Hal is halogen and the other is halogen, an objective compound can be obtained (Acc. Chem. Res. 1982, 15, 340–348). Any usual palladium catalyst is applicable and Pd(PPh₃)₄, PdCl₂(dppf), PdCl₂(PPh₃)₂, PdCl₂(P(o-Tolyl)₃)₂, Pd(OAc)₂ and the like are exemplified as preferable examples.

All of these reactions may be carried out in a suitable solvent (for example, dimethylformamide, tetrahydrofuran or the like) at room temperature or with heating for several tens minutes to several tens hours.

Process for Producing the Compound (I′″) [Process b]

As another easier processes for producing the compound (I′″), the following process wherein the compound of the formulas (IV), (V) and (VI) are coupled is also applicable.

wherein R¹–R¹³, X and Y are the same as defined in the above formulas (I), (II) and (III) and A¹, A², Z¹ and Z² are the same as defined in the above A and Z, respectively. The reactivity of A¹ is higher than or equal to that of A² in the compound (IV) and the reactivity of A² is higher than or equal to that of A¹ in the compound (IV′).

For production of the compound (I′″) by the above process the compound (IV) may be reacted with the compound (V), followed by the reaction with the compound (VI) without an isolation. The objective compound can be obtained also by a process wherein the compound (IV′) is reacted with the compound (VI), followed by a reaction with the compound (V).

Because the reactions of the substituents A¹ and Z¹ and the substituents A² and Z² are necessary to obtain the objective compound, the reactivity of the substituent A¹ and that of A² should be different. A preferable example is the combination that A¹ is iodine and A² is bromine or OTf in the compound (IV). Conversely in the compound (IV′) iodine for A² and bromine or OTf for A¹ are preferable. In the case that the compound (IV) or (IV′) is a symmetry compound, the objective compound is obtained even if A¹ and A² are the same group.

The substituents Z¹ and Z² may be the same or different group.

Various other conditions in this process are the same as those in the “Process a”.

In the above compounds, the substituents R¹–R¹³ may be any of the groups which do not affect the reaction (for example, a group other than halogen and —OSO₂(C_(q)F_(2q+1)) wherein q is an integer of 0 to 4) or any of the groups which do not affect the reaction and are changeable to R¹–R¹³ by a usual reaction. In the latter case the substituents may be changed to R¹–R¹³ in suitable steps according to the reaction of each compound.

For example, in the case that a substituent is formyl and an objective substituent is hydroxy, after the substituent is changed to formyloxy by the Baeyer-Villiger reaction etc., a usual hydrolysis reaction may be carried out under an acidic or alkaline condition. Specifically, a compound which has formyl is reacted with a peroxy acid such as peracetic acid, perbenzoic acid, m-chloroperbenzoic acid, trifluoroperacetic acid, hydrogen peroxide or the like in a suitable solvent such as 1,2-dichloroethane, chloroform, dichloromethane, carbon tetrachloride, benzene or the like at −20° C. or with heating for several minutes to several tens hours, followed by the hydrolysis of the obtained compound which has formyloxy under an acidic condition (for example, with heating with hydrochloric acid) or under a basic condition (for example, with heating with sodium hydroxide).

In the case that a substituent is formyl and an objective substituent is hydroxymethyl, the compound which has formyl may be reacted with a reductant such as sodium borohydride, lithium borohydride, zinc borohydride, triethyllithium borohydride, alminium hydride, diisobutylalminium hydride or the like in a solvent (for example, methanol, ethanol, isopropanol, dimethylsulfoxide, diethylene glycol dimethoxyethane, tetrahydrofuran, benzene, toluene, cyclohexane or the like) which is suitable for the reductant at −20° C. to 80° C., preferably under ice-cooling or at room temperature, for several tens minutes to several hours.

In the case that a substituent is formyl and an objective substituent is alkenyl having additional carbon atoms, an objective compound can be obtained by the Wittig Reaction (Organic Reaction, 1965, vol. 14, p. 270).

In the case that a substituent is formyl and an objective substituent is carboxy, the compound which has formyl may be reacted with an oxidizing agent such as sodium chlorite, the Jones Reagent, chromic anhydride or the like in a solvent such as tert-butanol, acetone or the like which is suitable for the oxidizing agent at 0° C. or with heating for several hours. The reaction is preferably carried out by addition of 2-methyl-2-buten, sodium dihydrogenphosphate or the like if needed.

In the case that a substituent is hydroxy and an objective substituent is substituted lower alkoxy, the compound which has hydroxy may be reacted with a proper alkylating agent in the presence of a base such as sodium carbonate, sodium bicarbonate, potassium carbonate, calcium hydroxide, barium hydroxide, calcium carbonate or the like in a suitable solvent such as tetrahydrofuran, acetone, dimethylformamide, acetonitrile or the like. Specifically, the reaction of a compound which has hydroxy with a proper halogenated compound such as methyl iodoacetate, ethyl chloroacetate, propyl chloroacetate or the like can give a compound of which substituent is alkoxycarbonyl(lower)alkoxy.

In the case that a substituent is carboxy and an objective substituent is carbamoyl, the compound which has carboxy may be carbamoylated with an amine such as ammonia, dimethylamine or the like at 0° C. or with heating for several minutes to several hours in a suitable solvent such as tetrahydrofuran, dimethylformamide, diethyl ether, dichloromethane or the like, if necessary after activation by an activating agent such as thionyl chloride, an acid halide, an acid anhydride, an activated ester or the like.

In the case that a substituent is hydrogen and an objective substituent is halogen, the compound which has hydrogen may be halogenated by a halogenating agent which is generally used (for example, bromine, chlorine, iodine, sulfuryl chloride, N-bromosuccinimide, N-iodosuccinimide or the like) in a suitable solvent such as chloroform, dichloromethane, carbon tetrachloride, acetonitrile, nitromethane, acetic acid, acetic anhydride or the like, if necessary in the presence of a catalyst such as the Lewis acid, hydrochloric acid, phosphoric acid or the like at −20° C. or with heating for several minutes to several tens hours.

The compound (I) can be obtained by a reaction of the compound (II) which has a substituent —X—Y with the compound (III) or a reaction of the compound (III′) which has a substituent —X—Y with the compound (II′). Further, the compound (I) can also be obtained by a reaction of the compound (II) or (III′) which has a substituent —W which is convertible into a substituent —X—Y with the compound (III) or (II′), followed by a conversion of a substituent —W into a substituent —X—Y.

For example, in the case of a compound wherein —W is hydroxy or protected hydroxy, an objective substituent such as lower alkyl, lower alkenyl, lower alkynyl, acyl, cycloalkyl, cycloalkenyl, aryl, heterocyclyl, lower alkoxy or the like may be introduced by a usual reaction.

Concretely, to obtain a compound wherein X is —O—, a compound wherein —W is hydroxy is synthesized and dissolved in a suitable solvent (for example, dimethylformamide, tetrahydrofuran, acetone, benzene, dioxane, acetonitrile or the like), followed by addition of a base such as hydroxides or carbonates of alkaline metals or alkaline-earth metals (for example, sodium carbonate, sodium bicarbonate, potassium carbonate, calcium hydroxide, barium hydroxide, calcium carbonate and the like) or tertiary amines such as triethylamine and the like. To the reactant is added a compound Y—V wherein V is halogen or —OSO₂(C_(q)F_(2q+1)) wherein q is an integer of 0–4 (for example, prenyl bromide, cyclohexenyl bromide, cinnamyl bromide, 1-bromo-2-penten, geranyl bromide, 5-bromo-2-methyl-2-penten, 1,3-dichloro-2-buten, 3-chloropropyne, prenyl triflate, cyclohexenyl triflate, 1,3-trichloropropene or the like) at −20° C. or with heating for several minutes to several tens hours to obtain an objective compound wherein —W has been converted into —O—Y.

To obtain a compound wherein X is —CH₂—, —N R¹⁴— or —S—, a compound wherein —W is hydroxy is reacted with trifluoromethanesulfonic anhydride etc. in a solvent such as anhydrous dichloromethane, chloroform, carbon tetrachloride or the like in the presence of a base such as pyridine, triethylamine or the like to obtain a triflate. Then, the obtained compound is reacted with Y—V′ wherein V′ is —CH₂ZnI, —SH, —NHR¹⁴ in the presence of a catalyst such as palladium, nickel or the like in a suitable solvent such as tetrahydrofuran, dimethylformamide, diethyl ether, dimethoxyethane or the like to give an objective compound.

In the case that X is NR¹⁴, a compound wherein W is NH₂ may be reacted with a ketone or an aldehyde in a suitable solvent such as tetrahydrofuran, methanol or the like, followed by reduction with a suitable reductant such as sodium borohydride, sodium cyanoborohydride, zinc hydrochloride or the like or by catalytic reduction to obtain an objective compound.

A usual reaction of a compound wherein W is NH₂ with Y—V″ wherein Y is acyl, lower alkylsulfonyl optionally substituted or arylsulfonyl optionally substituted and V″ is a leaving group such as halogen gives a compound wherein —X—Y is —NH—Y.

To obtain a compound wherein X is —SO— or —SO₂—, a compound wherein X is —S— which is synthesized by the above mentioned process may be oxidized with a usual oxidizing agent such as m-chloroperbenzoic acid.

A compound of the present invention wherein —X—Y is lower alkenyloxy is dissolved in a solvent such as ethanol, ethyl acetate or the like and hydrogenated with a catalyst such as Pd-carbon powder, platinum, rhodium, ruthenium, nickel or the like to give a compound wherein —X—Y is lower alkoxy.

A reaction of a compound wherein —X—Y is lower alkenyloxy with m-chloroperbenzoic acid or the like in a solvent such as dichloromethane, chloroform, benzene, hexane, tert-butanol or the like gives a compound wherein —X—Y is epoxidated lower alkoxy.

In the case that a compound has a substituent interfering of a reaction, the substituent may be protected with a suitable protecting group in advance and the protecting group may be left in a suitable step by a usual method. For example, if hydroxy interferes the reaction, hydroxy may be protected with methoxymethyl, methanesulfonyl, benzyl, trifluoromethanesulfonyl, tert-butyldimethylsilyl or the like, followed by deprotection in a suitable step.

For example, for a protection of hydroxy with methanesulfonyl, a compound which has hydroxy may be reacted with methanesulfonyl chloride in a solvent such as dichloromethane, chloroform, carbon tetrachloride or the like in the presence of a base such as triethylamine, pyridine or the like under ice-cooling or at room temperature for several hours. The protected compound may be deprotected with 1–4 N sodium hydroxide, potassium hydroxide, aqueous solution thereof, sodium methoxide, ethyl magnesium bromide or the like in a solvent such as dimethylsulfoxide, dimethylformamide, tetrahydrofuran, dioxane, dimethoxyethane or the like at room temperature or with heating for several tens minutes to several hours.

When methoxymethyl is used as a protecting group of hydroxy, a compound which has hydroxy may be reacted with chloromethylmethylether in a solvent such as tetrahydrofuran, dioxane, dimethoxyethane or the like in the presence of sodium hydride, diisopropylethylamine or the like to obtain a compound which has a protected hydroxy group. The compound may be subjected to a usual deprotection reaction with hydrochloric acid, sulfuric acid or the like in a solvent such as methanol, tetrahydrofuran, acetic acid or the like for a deprotection.

When tert-butyldimethylsilyl is used as a protective group, a compound which has hydroxy may be reacted with tert-butyldimethylsilyl chloride, tert-butyldimethylsilyl triflate or the like in a solvent such as dimethylformamide, acetonitrile, tetrahydrofuran, dimethylformamide, dichloromethane or the like in the presence of imidazole, triethylamine, 2,6-lutidine or the like. For a deprotection reaction the protected compound may be reacted with tetrabutylammonium fluoride or the like in a solvent such as tetrahydrofuran or the like.

Both of known compounds and the compounds which are produced by the following process may be used as the compounds (III) and (III′) in the above scheme.

Known compounds (VIII) and (IX), or (VIII′) and (IX′) wherein A and Z are groups which can be subjected to a coupling reaction by the Suzuki Reaction with each other; for example, one is borane such as dihydroxyborane, di(lower)alkoxyborane or the like and the other is halogen or —OSO₂(C_(q)F_(2q+1)) wherein q is an integer of 0–4; D is a group other than halogen and —OSO₂(C_(q)F_(2q+1)) wherein q is the same as defined above are reacted by the same method as above to obtain a compound (VII) or (VII′).

As described above, instead of a compound which has borane, a compound which has —SiR¹⁷ _(3-r)(Hal)_(r) wherein R¹⁷ is each independently lower alkyl, Hal is halogen and r is an integer of 1–3, —SnR¹⁸ ₃ wherein R¹⁸ is each independently lower alkyl or —Zn(Hal) wherein Hal is halogen may be used for a reaction to obtain an objective compound.

Then, a substituent D is converted into a substituent A which is applicable to the Suzuki Reaction.

For example, a compound wherein D is hydrogen may be reacted with a halogenating agent such as bromine, chlorine, iodine, sulfuryl chloride, N-bromosuccinimide or the like in a suitable solvent such as acetic acid, chloroform, dichloromethane, carbon tetrachloride, water, acetic acid-sodium acetate or the like at −20° C. or with heating for several minutes to several tens hours to give an objective compound wherein A is halogen.

A compound wherein D is protected hydroxy may be reacted with a trifluoromethanesulfonating agent such as trifluoromethanesulfonic anhydride, trifluoromethansulfonyl chloride or the like in a suitable solvent such as dichloromethane, chloroform, tetrahydrofuran or benzene in the presence of a base such as pyridine or triethylamine at −20° C. or with heating for several minutes to several tens hours to give an objective compound wherein A is OTf.

A compound of the present invention thus obtained can be converted into prodrug thereof. Any usual methods for conversion into a prodrug may be used. For example, hydroxy or amino which is attached a compound of the present invention at any position may be substituted with a usual group for a prodrug. An example of conversion into a prodrug is a substitution of hydroxy with acyloxy substituted with carboxy, sulfo, amino, lower alkylamino or the like, phosphonoxy etc. A substitution of hydroxy for R¹ with —OCOCH₂CH₂COOH, —OCOCH═CHCOOH, —OCOCH₂SO₃H, —OPO₃H₂, —OCOCH₂NMe₂, —OCO-Pyr wherein Pyr is pyridine or the like is preferable.

A selective suppressor of the IgE production of the present invention comprises a compound which suppresses the IgE production in a process from a differentiation of a mature B cell into an antibody-producing cell to the production of an antibody and which does not suppress or weakly suppresses the production of the immunoglobulins IgG, IgM and/or IgA which are produced at the same time.

The term “suppresses the IgE production in a process from a differentiation of a mature B cell into an antibody-producing cell to the production of an antibody” means to suppress the IgE production by inhibiting one of the following processes.

-   1) A process wherein mature B cells are activated by various factors     such as cytokines, i.e., IL-4, IL-5, etc., anti-CD40 antibody or the     like, -   2) A process wherein the activated B cells differentiate into     antibody-producing cells such as plasma cells etc. (concretely, a     process of switching of the activated B cells to IgE class     antibody-producing cells) and/or -   3) A process wherein the antibody-producing cells produce     immunoglobulins (specifically, a process of the IgE production)

An inhibition of “a process wherein a mature B cell is activated by various factors” in the process 1) does not include an inhibition of a process wherein the factors are produced from other cells and the like.

The term “suppresses the IgE production and does not suppress or weakly suppresses the production of the immunoglobulins IgG, IgM and/or IgA which are produced at the same time” means that the IgE production is suppressed enough to suppress allergy reactions and that the IgG, IgM and/or IgA production is not suppressed so potent as to badly affect an immune system concerning a living body protection under the condition that IgE and one or more of IgG, IgM and IgA can be produced at the same time. In other words,

-   {circle around (0)} The suppression of the IgE production is 5,000     times, preferably 10,000 times, more preferably 15,000 times, most     preferably 20,000 times or more as potent as those of the IgG, IgM     and/or IgA production and/or -   {circle around (2)} The IgG, IgM and/or IgA production is not     suppressed to less than 50% even at 5,000 times, preferably 10,000     times, more preferably 15,000 times, most preferably 20,000 times     the concentration at which 50% of the IgE production is suppressed     as compared with that in the absence of the suppressor.

The term “the concentration at which 50% of the IgE production is suppressed as compared with that in the absence of the suppressor” means a concentration at which the IgE production is limited to 50% of the production in the absence or without administration of the selective suppressor of the IgE production of the present invention under the condition that the IgE can be produced. The suppressor is useful as a medicament when it has a selectivity for the IgE as compared with at least one of IgG, IgM or IgA, preferably with all of them.

The selective suppressor of the IgE production of the present invention suppresses 90% or more of the IgE production as compared with that without administration of the suppressor at a dosage that the suppressor does not suppress or weakly suppresses the IgM, IgG and/or IgA production when the suppressor is administered to a mammal, which includes human, sensitized by an allergen. The term “allergen” means any substance that can induce the IgE production and an allergic reaction. Clinical examples are pollen, a acarid, house dust, albumin, milk, a soybean etc. and experimental examples are ovalbumin, bovine gamma globulin, bovine serum albumin, an antigen protein of cedar pollen (Cryj I and Cryj II), an antigen protein for acarid (Derf I and Derf II) etc. The term “a dosage that the suppressor does not suppress or weakly suppresses the IgM, IgG and/or IgA production” means the dosage at which the suppression rate of the IgG, IgM and/or IgA is 10% or less, preferably 5% or less, more preferably 3% or less as compared with those produced without administration of the selective suppressor of the IgE production of the present invention.

The selective suppressor of the IgE production of the present invention suppresses infiltration of an inflammatory cell to a tissue. The term “inflammatory cell” includes all of a lymphocyte, an eosinophil, a neutrophile and a macrophage, and an eosinophil and/or a neutrophile are preferable.

The effect of the selective suppressor on the IgE production of the present invention is potent for its direct action to B cells. Because the suppressor does not affect the humoral immunity concerning a biological protective reaction, it has many advantages, for example, little side effect such as infections etc.,

All of compounds that have the above effect are useful as an immunosuppressor regardless of the structure and one of the examples is the compound (I) or (I″) of the present invention.

The compounds of the present invention also include ones which have the suppressive effect on a mitogen reaction and/or a cytokine reaction.

Specifically, the compounds have a potent antiproliferative effect on T and/or B cells and/or a suppressive effect on the IL-5 and/or IL-4 production. They selectively suppress the IL-4 and/or IL-5 production and do not suppress the IL-2 production.

The immunosuppressor or anti-allergic agent of the present invention is useful for prevention or a treatment of allergic diseases such as a rejection symptom against a transplantation of an organ or a tissue, a graft-versus-host reaction which is caused by a bone marrow transplantation, atopic allergic diseases (for example, a bronchial asthma, an allergic rhinitis, an allergic dermatitis and the like), a hypereosinophils syndrome, an allergic conjunctivitis, a systemic lupus erythematosus, a polymyositis, a dermatomyositis, a scleriasis, MCTD, a chronic rheumatoid arthritis, an inflammatory bowel disease, an injury caused by ischemia-reperfusion, a pollenosis, an allergic rhinitis, an urticaria, a psoriasis and the like.

When the compound of the present invention is administered as a immunosuppressor and/or anti-allergic agent, it can safely be administered both orally and parenterally. In the case of an oral administration, it may be in any usual forms such as tablets, granules, powders, capsules, pills, solutions, suspensions, syrups, buccal tablets, sublingual tablets and the like for the administration. When the compound is parenterally administered, any usual forms are preferable, for example, injections such as intravenous injections and intramuscular injections, suppositories, endermic agents, vapors and the like. An oral administration is particularly preferable.

A pharmaceutical composition may be manufactured by mixing an effective amount of the compound of the present invention with various pharmaceutical ingredients suitable for the administration form, such as excipients, binders, moistening agents, disintegrators, lubricants, diluents and the like. When the composition is of an injection, an active ingredient can be sterilized with a suitable carrier to give a pharmaceutical composition.

Specifically, examples of the excipients include lactose, saccharose, glucose, starch, calcium carbonate, crystalline cellulose and the like, examples of the binders include methylcellulose, carboxymethylcellulose, hydroxypropylcellulose, gelatin, polyvinylpyrrolidone and the like, examples of the disintegrators include carboxymethylcellulose, sodium carboxymethylcellulose, starch, sodium alginate, agar, sodium lauryl sulfate and the like, and examples of the lubricants include talc, magnesium stearate, macrogol and the like. Cacao oil, macrogol, methyl cellulose and the like may be used as base materials of suppositories. When the composition is manufactured as solutions, emulsified injections or suspended injections, dissolving accelerators, suspending agents, emulsifiers, stabilizers, preservatives, isotonic agents and the like may be added. For an oral administration, sweetening agents, flavors and the like may be added.

Although a dosage of the compound of the present invention as an immunosuppressor and/or anti-allergic agent should be determined in consideration of the patient's age and body weight, the type and degree of diseases, the administration route or the like, a usual oral dosage for human adults is 0.05–100 mg/kg/day and the preferable dosage is 0.1–10 mg/kg/day. In the case that it is parenterally administered, although the dosage highly varies with administration routes, a usual dosage is 0.005–10 mg/kg/day, preferably, 0.01–1 mg/kg/day. The dosage may be administered in one or some separate administrations.

The present invention is further explained by the following Examples and Experiments, which are not intended to limit the scope of the present invention.

EXAMPLE

The abbreviations which are used in EXAMPLE mean the following.

Bn benzyl DME 1,2-dimethoxyethane DMF N,N-dimethylformamide DMSO dimethylsulfoxide MCPBA m-chloroperbenzoic acid MOM methoxymethyl Ms methanesulfonyl Py pyridyl TBS tert-butyldimethylsilyl Tf trifluoromethanesulfonyl Ts p-toluenesulfonyl

Example 1 Synthesis of the Compounds (I-1), (I-2) and (I-3)

(Step 1) Synthesis of the Compound 1

To 300 ml of a solution of 10.63 g (22.08 mmol) of a compound (III-1) in 1,2-dimethoxyethane was added 3.60 g (3.12 mmol) of tetrakis(triphenylphosphine)palladium (0) at room temperature. To the mixture were added 80 ml of a solution of a compound 2 (9.50 g; 26.5 mmol) in 99% ethanol and 125 ml (250 mmol) of an aqueous solution of 2 M sodium carbonate and the reacted suspension was heated under refluxing in an argon atmosphere for 6 hours. After cooling, the reaction mixture was filtered off to remove an insoluble material and the filtrate was acidified with 2 N hydrochloric acid and extracted with ethyl acetate. The extract was washed with 5% aqueous solution of sodium bicarbonate and saturated brine successively, then dried and concentrated. After the residue was purified by silica gel chromatography (hexane-ethyl acetate 1:1), the obtained product was recrystallized from hexane-ethyl acetate to give the compound 1 (11.57 g; 87% yield) as colorless crystals.

(Step 2) Synthesis of the Compound (I-2)

To 60 ml of a suspension of the compound 1 (9.30 g; 15.48 mmol) in anhydrous dichloromethane was added 3.24 ml (23.22 mmol) of triethylamine, followed by addition of 1.80 ml (23.22 mmol) of methanesulfonyl chloride under ice-cooling and stirred for 2 hours at the same temperature. After the solvent was removed, the residue was acidified with 80 ml of 1 N hydrochloric acid and extracted with chloroform. The extract was washed with 1 N hydrochloric acid, 5% aqueous solution of sodium bicarbonate and saturated brine successively, and the obtained product was dried and concentrated. The obtained residue was recrystallized from hexane-ethyl acetate to give 9.93 g of the compound (I-2) (95% yield) as colorless crystals.

(Step 3) Synthesis of the Compound 3

Stirred were 300 ml of a solution of 9.76 g (14.38 mmol) of the compound (I-2) and 765 mg (4.31 mmol) of palladium chloride (II) in 1,4-dioxane under a hydrogen atmosphere at room temperature for 15 hours. An insoluble material was removed off by filtration with celite and the obtained filtrate was concentrated. The residue was recrystallized from hexane-ethyl acetate to give the compound 3 (8.43 g; 100% yield) as colorless crystals.

(Step 4) Synthesis of the Compound (I-3)

To 40 ml of a solution of the compound 3 (4.01 g; 6.81 mmol) in anhydrous N,N-dimethylformamide were added successive, 1.45 g (10.5 mmol) of potassium carbonate and 1.21 ml (10.5 mmol) of prenyl bromide. After the mixture was stirred under a nitrogen atmosphere for 15 hours at room temperature, the reaction mixture was poured into 230 ml of 6% aqueous citric acid and extracted with ethyl acetate. The extract was washed with 5% citric acid, 5% aqueous solution of sodium bicarbonate and saturated brine successively, followed by being dried and concentrated. The residue was recrystallized from hexane-ethyl acetate to give 4.01 g of the compound (I-3) (90% yield) as colorless crystals.

(Step 5) Synthesis of the Compound (I-1)

To 38 ml of a solution of 3.80 g (5.79 mmol) of the compound (I-3) in dimethylsulfoxide was added 15 ml (60.0 mmol) of 4 N sodium hydroxide and the reaction mixture was warmed at 60° C. for 4 hours. After the mixture was cooled, 100 ml of 1 N hydrochloric acid was added to it and the obtained mixture was extracted with ethyl acetate. The extract was washed with 5% aqueous solution of sodium bicarbonate and saturated brine successively, then dried and concentrated. The residue was recrystallized from methanol to give 1.72 g of the compound (I-1) (70% yield) as colorless crystals.

Reference Example 1 Synthesis of the Compound 2

To a solution of the compound 4 (80.0 g; 0.287 mol) in 300 ml of N,N-dimethylformamide were added tert-butyldimethylsilyl chloride (45.87 g; 0.296 mol) and imidazole (21.46 g; 0.315 mol) and stirred at room temperature for 19 hours. The reaction mixture was poured into 1 L of water and extracted with ether. The extract was washed with water and saturated brine successively and then dried and concentrated. The residue was purified by silica gel chromatography (hexane-ethyl acetate 50:1) to give the compound 5 (97.20 g; 86% yield) as a colorless oil.

To 850 ml of a solution of the compound 5 (97.20 g; 0.247 mol) in annydrous tetrahydrofuran was added 152 ml (0.252 mol) of a solution of 1.66 N n-butyllithium in hexane under a nitrogen atmosphere at −70° C. and stirred at the same temperature for 1.5 hours. To the mixture was added 171 ml (0.741 mol) of triisopropyl borate at −70° C. and stirred for 3 hours with gradually warming to room temperature. Under cooling with ice, 500 ml of water and 320 ml of 5% citric acid were added to the mixture and stirred at the same temperature for 30 minutes. The solution was extracted with ethyl acetate and the extract was washed with water and saturated brine successively, then dried and concentrated. The residue was purified by silica gel chromatography (hexane-ethyl acetate 2:1) to give the compound 2 (51.10 g; 58% yield) as colorless crystals.

Reference Example 2 Synthesis of the Compound (III-1)

(Step 1) Synthesis of the Compound 8

To a solution of 15.30 g (62.4 mmol) of a compound 7 (Journal of Chemical Society, 1925, 1998) in 300 ml of 1,2-dimethoxyethane was added 3.60 g (3.12 mmol) of tetrakis(triphenylphosphine)palladium (0) at room temperature. To the mixture were added a solution of 18.89 g (74.9 mmol) of a compound 6 (GB-A No. 2276162) in 80 ml of 99% ethanol and 125 ml (250 mmol) of an aqueous solution of 2 M sodium carbonate and the reaction suspension was heated under refluxing in an argon atmosphere for 6 hours. After cooling, the reaction mixture was filtered off to remove an insoluble substance. The filtrate was acidified with 2 N hydrochloric acid and extracted with ethyl acetate. The extract was washed with 5% aqueous solution of sodium bicarbonate and saturated brine successively, then dried and concentrated. The residue was purified by silica gel chromatography (hexane-ethylacetate 1:1) and recrystallized from hexane-ethyl acetate to give the compound 8 (15.68 g; 97% yield) as colorless crystals.

(Step 2) Synthesis of the Compound 9

To a suspension of the compound 8 (15.34 g; 59.39 mmol) in 240 ml of anhydrous dichloromethane were added 16.6 ml (118.8 mmol) of triethylamine and 6.93 ml (89.09 mmol) of methanesulfonyl chloride under ice-cooling and stirred at the same temperature for 2 hours. After the solvent was removed, the residue was acidified with 1 N hydrochloric acid (100 ml) and extracted with ethyl acetate. The extract was washed with 1 N hydrochloric acid, 5% aqueous solution of sodium bicarbonate and, saturated brine successively, then dried and concentrated. The residue was recrystallized from hexane-ethyl acetate to give the compound 9 (17.24 g; 86% yield) as colorless crystals.

(Step 3) Synthesis of the Compound (III-24)

To 210 ml of a suspension of the compound 9 (17.03 g; 50.63 mmol) in acetic acid were added 6.23 g (75.95 mmol) of sodium acetate and 3.91 ml (75.95 mmol) of bromine at room temperature and stirred at the same temperature for 16 hours. After 3.91 ml (75.95 mmol) of bromine was added to the reacted suspension and stirred at 50° C. for 4 hours, 3.91 ml (75.95 mmol) of bromine was added and stirred at 50° C. for 3 hours. The reaction mixture was poured into 1 L of 1 M aqueous sodium thiosulfate and stirred for 30 minutes. The precipitate was collected by filtration and washed with water. The obtained crystals were dissolved in 800 ml of chloroform, washed with 5% aqueous solution of sodium bicarbonate and saturated brine successively, then dried and concentrated. The residue was recrystallized from hexane-ethyl acetate to give the compound (III-24) (18.12 g; 86% yield) as colorless crystals.

(Step 4) Synthesis of the Compound 10

To a suspension of the compound (III-24) (15.80 g; 38.05 mmol) in 400 ml of 1,2-dichloroethane was added 12.30 g (57.05 mmol) of 80% m-chloroperoxybenzoic acid at room temperature and stirred at the same temperature for 17 hours. The reaction mixture was poured into 360 ml of 0.2 M aqueous sodium thiosulfate and extracted with chloroform. The extract was washed with 300 ml of 0.2 M sodium thiosulfate and 200 ml of 5% of sodium bicarbonate (×2) successively, then dried and concentrated. The residue (15.80 g) was dissolved in 330 ml of 1,2-dimethoxyethane and 30 ml (120 mmol) of 4 N hydrochloric acid was added. After the reaction mixture was stirred at 50° C. for 12 hours and cooled, the solvent was removed and the residue was extracted with ethyl acetate. The extract was washed with 5% aqueous solution of sodium bicarbonate and saturated brine successively, then dried and concentrated to give the compound 10 (14.35 g; 97% yield) as pale brown crystals.

(Step 5) Synthesis of the Compound (III-1)

Using an analogous procedure for the compound (I-4), 12.63 g of the compound (III-1) as colorless crystals (88% yield) was obtained from the compound 10 (12.0 g; 29.76 mmol).

Example 2 Synthesis of the Compound (I-4)

(Step 1) Synthesis of the Compound 11

To a solution of 816 mg (2 mmol) of a compound (III-2) in 40 ml of 1,4-dioxane were added 114 mg (0.1 mmol) of tetrakis(triphenylphosphine)palladium (0), 748 mg (2.09 mmol) of the compound 2 and 589 mg (2.77 mmol) of powders of anhydrous potassium phosphate at room temperature and heated in a nitrogen atmosphere at 85° C. for 23 hours. The reaction mixture was cooled and extracted with ethyl acetate. The extract was washed with 2 N hydrochloric acid, 5% aqueous sodium bicarbonate and saturated brine successively, then dried and concentrated. The residue was purified by silica gel chromatography (hexane-ethyl acetate 4:1) and crystallized from pentane to give the compound 11 (745 mg; 67% yield) as pale yellow crystals.

(Step 2) Synthesis of the Compound (I-4)

To a solution of the compound 11 (557 mg; 1 mmol) in 10 ml of dichloromethane was added 259 mg (1.2 mmol) of 80% m-chloroperbenzoic acid at room temperature and stirred for 15 hours. The reaction mixture was poured into 0.1 M aqueous sodium thiosulfate and extracted with ethyl acetate. The extract was washed with 0.1 M aqueous sodium thiosulfate, 5% aqueous sodium bicarbonate and saturated brine successively, then dried and concentrated. To a solution of 650 mg of the obtained residue in 5 ml of methanol was added a solution of 1 M sodium methoxide in 2 ml of methanol under ice-cooling and stirred for 30 minutes. After the reacted solution was acidified with 2 N hydrochloric acid and extracted with ethyl acetate, the extract was washed with saturated brine, then dried and concentrated. To a solution of 647 mg of the obtained residue in 10 ml of tetrahydrofuran was added 2 ml of 1 M tetrabutylammonium fluoride in tetrahydrofuran under ice-cooling and stirred for 30 minutes. The obtained reaction mixture was poured into 2 N aqueous hydrochloric acid under ice-cooling to acidify and extracted with ethyl acetate. The ethyl acetate layer was washed with water, 5% aqueous sodium bicarbonate and saturated brine successively, then dried and concentrated. The residue was purified by silica gel chromatography (hexane-ethyl acetate 2:1) to give 275 mg of the compound (I-4) (62% yield) as powders.

Reference Example 3 Synthesis of the Compound (III-2)

(Step 1) Synthesis of the Compound 13

To 26 ml of a solution of 2.61 g (10 mmol) of a compound 12 (Journal of Organic Chemistry, 1987, 52, 4485) in dimethylformamide were added 400 mg (10 mmol) of 60% sodium hydride dispersion in oil and 836 mg (11 mmol) of chloromethyl methyl ether under ice-cooling and stirred for 30 minutes. After warming to room temperature, it was further stirred for 1 hours. The reaction mixture was concentrated under reduced pressure and extracted with ethyl acetate. The extract was washed with 5% aqueous solution of sodium bicarbonate and saturated brine successively, then dried and concentrated. The residue was recrystallized from ethyl acetate-hexane-pentane to give the compound 13 (2.8 g; 92% yield).

(Step 2) Synthesis of the Compound 14

Using an analogous procedure for the compound 8, the compound 14 was obtained as a pale yellow oil (96% yield) from the compound 13 and the compound 15 (Tokyo Kasei Kogyo Co., Ltd.).

(Step 3) Synthesis of the Compound 16

To 16 ml of a suspension of 1.38 g (4.3 mmol) of the compound 14 in methanol was added 4 ml of 2 N aqueous hydrochloric acid and stirred for 1 hour under warming at 60° C. The reaction mixture was concentrated under reduced pressure and extracted with ethyl acetate. The extract was washed with 5% aqueous sodium bicarbonate and saturated brine successively, then dried and concentrated to give the compound 16 (1.12 g; 94% yield) as a yellow crystalline residue.

(Step 4) Synthesis of the Compound (III-2)

To 12 ml of a solution of the compound 16 (1.12 g; 4.05 mmol) in anhydrous dichloromethane was added 1.02 ml (6.08 mmol) of trifluoromethanesulfonic anhydride and then 980 ml (12.2 mmol) of pyridine under ice-cooling and stirred for 30 minutes. The reaction mixture was allowed to warm to room temperature and stirred for additional 2 hours and the solvent was removed. The residue was extracted with ethyl acetate, washed with 5% aqueous sodium bicarbonate and saturated brine successively, then dried and concentrated. The obtained crude product was purified by silica gel chromatography to give 1.23 g of the compound (III-2) (74% yield) as a white crystalline residue.

Example 3 Synthesis of the Compounds (I-5), (I-6) and (I-7)

(Step 1) Synthesis of the Compound (I-5)

Using an analogous procedure for the compound 1 in Example 1, 634 mg (0.972 mmol) of the compound (I-5) was synthesized from 881 mg (1.50 mmol) of the compound (III-11) and 370 mg (1.95 mmol) of 3-trifluoromethyl boric acid. 65% yield.

(Step 2) Synthesis of the Compound 18

Using an analogous procedure for the compound 3 in Example 1, the compound 18 (360 mg; 0.640 mmol) was synthesized from 433 mg (0.664 mmol) of the compound (I-5). 96% yield.

(Step 3) Synthesis of the Compound (I-6)

Using an analogous procedure for the compound (I-3) in Example 1, 185 mg (0.293 mmol) of the compound (I-6) was synthesized from the compound 18 (170 mg; 0.302 mmol). 97% yield.

(Step 4) Synthesis of the Compound (I-7)

Using an analogous procedure for the compound (I-1) in Example 1, 85 mg (0.179 mmol) of the compound (I-7) was synthesized from 150 mg (0.238 mmol) of the compound (I-6). 75% yield.

Reference Example 4 Synthesis of the Compound (III-11)

(Step 1) Synthesis of the Compound 19

Using an analogous procedure for the compound 10 in Reference Example 2, the compound 19 (24.04 g; 103 mmol) was synthesized from the compound 7 (40.03 g; 163 mmol). 63% yield.

(Step 2) Synthesis of the Compound 20

To a solution of tert-butylamine (5.0 ml; 47.8 mmol) in 10 ml of toluene was added iodine (5.94 g; 23.39 mmol) under a nitrogen atmosphere and stirred for 50 minutes at room temperature. The compound 19 (5.46 g; 23.43 mmol) was added to the solution under ice-cooling, then warmed to room temperature and stirred for 6 days. The reaction mixture was poured into 1 M of aqueous sodium thiosulfate and extracted with ethyl acetate. The extract was washed with 1 M aqueous sodium thiosulfate and saturated brine successively, then dried and concentrated to give the compound 20 (8.30 g; 23.16 mmol). 99% yield.

(Step 3) Synthesis of the Compound 21

Using an analogous procedure for the compound 1 in Example 1, the compound 21 (2.10 g; 4.87 mmol) was synthesized from the compound 20 (8.70 g; 24.20 mmol). 20% yield.

(Step 4) Synthesis of the Compound (III-11)

Using an analogous procedure for the compound (I-2) in Example 1, 2.61 g (4.44 mmol) of the compound (III-11) was synthesized from the compound 21 (3.20 g; 7.42 mmol). 60% yield.

Example 4 Synthesis of the Compound (I-9)

(Step 1) Synthesis of the Compound 22

Using an analogous procedure described in Reference Example 1, 1.53 g (3.63 mmol) of the compound (I-1) was silylated and the obtained crude product was crystallized from methanol to obtain the compound 22 (2.62 g; 95% yield) as colorless crystals.

(Step 2) Synthesis of the Compound 23

To a solution of the compound 22 (2.38 g; 3.1 mmol) in 90 ml of acetone were added 415 mg (3.74 mmol) of trimethylamine-N-oxide dihydrate and 1.60 ml of 5% aqueous solution of osmium tetroxide (0.3 mmol) and stirred for 1 hour at room temperature. After 20 ml of water was added to the reaction mixture, 4.0 g of sodium bicarbonate and 4.0 g of sodium bisulfite were added and stirred for 30 minutes. The reaction mixture was concentrated under reduced pressure and the residue was extracted with ethyl acetate. The extract was washed with saturated brine, then dried and concentrated.

A solution of 1.96 g (9.16 mmol) of sodium periodate in 33 ml of water was added dropwise to a solution of 2.46 g of the residue obtained by the above method in 90 ml of ethanol with stirring at room temperature. After stirring for 2 hours, 100 ml of water was added to the reaction mixture and the precipitate was collected by filtration and dried to give the compound 23 (1.98 g; 87% yield) as powder.

(Step 3) Synthesis of the Compound (I-9)

To a suspension of 146 mg (0.38 mmol) of n-propyltriphenylphosphonium bromide in 2.5 ml of anhydrous tetrahydrofuran was added 32 mg (0.29 mmol) of potassium tert-butoxide in a nitrogen atmosphere at 0° C. and stirred at the same temperature for 1 hour. The reaction mixture was cooled to −78° C., a solution of the compound 23 (70 mg; 0.095 mmol) in 1.5 ml of anhydrous tetrahydrofuran was added and stirred for 30 minutes at the same temperature and for additional 1 hour at room temperature. The reaction mixture was poured into an ice-cooling aqueous solution of saturated ammonium chloride and extracted with ethyl acetate. The extract was washed with saturated brine, then dried and concentrated.

Using an analogous procedure described in Example 2 Step 2, 70 mg of the residue obtained by the above method was desilylated and the obtained crude product was purified by silica gel chromatography (toluene-ethyl acetate 4:1) to give 37 mg of the compound (I-9) as pale yellow crystals.

Example 5 Synthesis of the Compound (I-565)

(Step 1) Synthesis of the Compound (I-563)

Using an analogous procedure for the compound 2 in Example 1, 850 mg of the compound (1–563) was obtained from a compound (III-27) (800 mg; 1.59 mmol) and the compound 2 (1.25 g; 3.50 mmol) as colorless crystals (86% yield).

(Step 2) Synthesis of the Compound (I-565)

To a solution of 120 mg (0.193 mmol) of the compound (I-563) in 3 ml dimethoxyethane and 1 ml of ethyl acetate was added 2.4 ml of 4 N hydrochloric acid at 40° C. and stirred at the same temperature for 2 hours 20 minutes. After cooling, the reaction mixture was neutralized with aqueous solution of saturated sodium bicarbonate and extracted with ethyl acetate. The extract was washed with saturated aqueous solution of sodium bicarbonate and saturate brine, then dried and concentrated. The obtained crude product was crystallized from hexane-ethyl acetate to give 93 mg of the compound (I-565) as pale yellow crystals (92% yield).

Reference Example 5 Synthesis of the Compound (III-27)

(Step 1) Synthesis of the Compound 24

In a mixture of 17.5 ml of tert-butanol and 5.3 ml of 2-methyl-2-butene was suspended 415 mg (1.00 mmol) of the compound (III-24), 6.7 ml of aqueous solution of 724 mg (8.00 mmol) of sodium chlorite and 968 mg (6.20 mmol) of sodium dihydrogen phosphate dihydrate was added and stirred at the same temperature for 4 hours 30 minutes. The solution of 1 M sodium thiosulfate was added to the reaction mixture and the mixture was extracted with ethyl acetate. Then, organic layer was extracted with aqueous solution of saturated sodium bicarbonate. Then the aqueous layer was acidified with conc. hydrochloric acid and extracted with ethyl acetate. The extract was washed with saturated brine, then dried and concentrated to give the compound 24 (384 mg; 89% yield) as colorless crystals.

(Step 2) Synthesis of the Compound (III-27)

To 10 ml of a suspension of the compound 24 (1.50 g; 3.48 mmol) in tert-butanol were added 0.533 ml (3.83 mmol) of triethylamine, followed by 0.825 ml (3.83 ml) of diphenyl phosphate azide, and the mixture was stirred at 100° C. for 23 hours. After the reaction mixture was cooled, water was added to it and the mixture was extracted with ethyl acetate. The extract was washed with saturated aqueous solution of sodium bicarbonate and saturated brine, then dried and concentrated. The residue was purified by silica gel chromatography (hexane-ethyl acetate 2.5:1) to give 1.43 g of the compound (III-27) as colorless form product (82% yield).

Example 6 Synthesis of the Compound (1–480)

To a solution of 120 mg of a compound which was eliminated a Boc group of the compound (I-479) in 2 ml of tetrahydrofuran and 0.5 ml of methanol were added 33 ml (0.34 mmol) of 3-methyl-2-butenal and 90 ml (0.26 mmol) of 3 M aqueous solution of sulfuric acid at 0° C. and stirred for 10 minutes. Further, 19.6 mg of sodium borohydride was added in small portions to the mixture and stirred at room temperature for 1 hour. The saturated aqueous solution of sodium bicarbonate was added to the reaction mixture and extracted with ethyl acetate. The extract was washed with saturated brine, then dried and concentrated. The residue was purified by silica gel chromatography (hexane-ethyl acetate 3:1) to give 98 mg of the compound (I-480) as colorless crystals (78% yield).

Example 7 Synthesis of the Compound (I-628)

Using an analogous procedure for the compound 1 in Example 1, 1.2 g (2 mmol) of the compound (III-44) was reacted with 551 mg (2.2 mmol) of 4-bromomethanesulfonyl anilide were reacted, followed by desilylated by an analogous procedure described in Example 1 Step 2. The obtained crude product was crystallized from ethyl acetate-hexane to obtain 760 mg of the compound (I-628) as pale yellow crystals (73% yield).

Reference Example 6 Synthesis of the Compound (III-44)

(Step 1) Synthesis of the Compound 25

Using an analogous procedure for the compound 5 in Reference Example 1, a crude product was synthesized by the reaction of 22.2 g (52.7 mmol) of the compound 21, 8.95 g (132 mmol) of imidazole and 17.5 g (1.16 mmol) of tert-butyldimethylsilyl chloride. The obtained product was purified by silica gel chromatography (ethyl acetate:hexane=1:20) and crystallized from ethyl acetate-hexane to give 29.7 g of the compound 25 as colorless crystals (85% yield).

(Step 2) Synthesis of the Compound (III-44)

Using an analogous procedure for the compound 2 in Reference Example 1,402.7 g (610 mmol) of the compound 25 was reacted with 678 ml (814 mmol) of 1.08 N s-butyl lithium in cyclohexane, followed by addition of 282 ml (1.22 mol) of triisopropyl borate to give 246 g of the compound (III-44) as colorless powders (65% yield).

Example 8 Synthesis of the Compound (I-233)

In an argon atmosphere, 2.87 g (8.0 mmol) of the compound 20 was dissolved in 32 ml of dimethoxyethane and 8 ml of ethanol, 3.01 g of the compound 2 and 16 ml of 2 M aqueous solution of sodium carbonate were added and the reaction mixture was degassed. To the mixture was added 462 mg (0.4 mmol) of palladium tetrakistriphenylphosphine and the mixture was heated under refluxing for 2 hours. After the reaction mixture was cooled to room temperature, 2.02 g (12.0 mmol) of 4-methylthiophenyl boronic acid, 462 mg (0.4 mmol) of palladium tetrakistriphenylphosphine, 16 ml of 2 M aqueous solution of sodium carbonate, 32 ml of dimethoxyethane and 8 ml of ethanol were added to it. Then, the reaction mixture was degassed again and heated under refluxing for 16 hours. After the reaction mixture was cooled to room temperature, 100 ml of 5% aqueous citric acid was added and stirred at the same temperature for 1 hour. Ethyl acetate was added to the reaction mixture and the organic layer was washed with 5% aqueous citric acid, water, saturated aqueous solution of sodium bicarbonate and saturated brine successively, then dried and concentrated. The residue was purified by silica gel chromatography (hexane-ethyl acetate 3:1) to obtain 2.13 g of crude crystals. The obtained crude crystals were recrystallized from hexane-ethyl acetate to give 1.66 g of the compound (1–233) as colorless crystals (44% yield)

Example 9 Synthesis of other Compounds

Following compounds (I) were synthesized by analogous procedures described above. The structures and physical constants of the compounds (III) and (I) are as follows.

TABLE 1 III-1 m.p. 201–203° C. ¹HNMR(DMSO-d₆) δ 3.44(s, 3H), 3.48(s, 3H), 3.62(s, 3H), 3.92(s, 3H), 7.09(s, 1H), 7.40–7.53(m, 2H), 7.65–7.78(m, 2H) III-2 ¹HNMR(CDCl₃) δ 3.47(s, 3H), 3.94(s, 3H), 7.13–7.24(m, 3H), 7.50–7.59(m, 2H), 10.41(s, 1H) IR(KBr)1700, 1562, 1479, 1438, 1393, 1226, 1199, 1180, 1161, 1076, 1047cm⁻¹ III-3 m.p. 181–182° C. ¹HNMR(CDCl₃) δ 3.21(s, 3H), 3.40(s, 3H), 3.49(s, 3H), 3.90(s, 3H), 4.81(s, 2H), 4.85(s, 2H), 6.86(s, 1H), 7.32–7.40(m, 2H), 7.60–7.68(m, 2H) IR(KBr)1504, 1467, 1370, 1235, 1152, 1038, 1010, 870, 846, 785cm⁻¹ III-4 ¹HNMR(CDCl₃) δ 2.95(s, 3H), 3.18(s, 3H), 3.21(s, 3H), 3.41(s, 3H), 3.91(s, 3H), 6.84(s, 1H), 7.37(d, J=8.9Hz, 2H), 7.63(d, J=8.9Hz, 2H) III-5 m.p. 140–141° C. ¹HNMR(CDCl₃) δ 3.21(s, 3H), 3.45(s, 3H), 3.48(s, 3H), 3.96(s, 3H), 7.40(d, J=8.9Hz, 2H), 7.54(d, J=8.9Hz, 2H) IR(KBr)1446, 1426, 1409, 1370, 1362, 1184, 1153, 1029, 973, 920, 870, 849, 776cm⁻¹ III-6 Tokyo Kasei Kogyo Co., Ltd. III-7 ¹HNMR(CDCl₃) δ: 3.51(s, 3H), 3.92(s, 3H), 6.05(s, 2H), 6.92(d, J=8.1Hz, 1H), 7.02(d, J=8.1Hz, 1H), 7.07(s, 1H), 7.18(s, 1H), 10.40(s, 1H) IR(KBr)1691, 1600, 1577, 1474, 1447, 1422, 1388, 1352, 1252, 1237, 1227, 1201, 1134, 1124, 1082, 1038cm⁻¹ III-8 ¹HNMR(CDCl₃) δ 3.20(s, 3H), 3.77(s, 3H), 3.90(s, 3H), 6.86(s, 1H), 6.98(s, 1H), 7.32–7.37(m, 2H), 7.51–7.56(m, 2H) III-9 HNMR(CDCl₃) δ 3.20(s, 3H), 3.34(s, 3H), 7.37–7.47(m, 3H), 7.53–7.63(m, 3H), 7.71(d, J=2.1Hz, 1H) III-10 ¹HNMR(CDCl₃) δ 3.76(s, 3H), 3.90(s, 3H), 6.85(s, 1H), 6.97(s, 1H), 7.08–7.15(m, 2H), 7.42–7.49(m, 2H) III-11 oil ¹HNMR(CDCl₃) δ 2.72(s, 3H), 3.11(s, 3H), 3.75(s, 3H), 3.92(s, 3H), 5.17(s, 2H), 7.05–7.16(m, 2H), 7.24–7.50(m, 2H).

TABLE 2 III-12 oil ¹HNMR(CDCl₃) δ 3.51(s, 3H), 3.70(s, 3H), 3.86(s, 3H), 3.89(s, 3H), 5.28(s, 2H), 6.65(s, 1H), 6.97&7.47(ABq, J=8.6Hz, 4H) III-13 m.p. 120–122° C. ¹HNMR(CDCl₃) δ 3.20(s, 3H), 3.53(s, 3H), 3.70(s, 3H), 3.89(s, 3H), 5.28(s, 2H), 6.63(s, 1H), 7.32–7.37(m, 2H), 7.56–7.61 (m, 2H) IR(KBr)1505, 1468, 1427, 1375, 1237, 1175, 1153, 1100, 1072, 1003, 972cm ⁻¹ III-14 m.p. 146–147° C. ¹HNMR(CDCl₃) δ 3.85(s, 3H), 6.94–7.01(m, 2H), 7.38–7.56(m, 6H) IR(KBr)1603, 1522, 1481, 1288, 1255, 1036cm⁻¹ III-15 ¹HNMR(CDCl₃) δ 3.07(s, 6H), 3.49(s, 3H), 3.92(s, 3H), 6.95(brs, 2H), 7.20(s, 1H)7.51(d, J=8.7Hz, 2H), 10.42(s, 1H) III-16 ¹HNMR(CDCl₃) δ 3.48(s, 3H), 3.50(s, 3H), 3.92(s, 3H), 6.81(s, 1H), 7.70(s, 4H) III-17 ¹HNMR(CDCl₃) δ 3.24(s, 3H), 3.49(s, 3H), 3.94(s, 3H), 7.21(s, 1H), 7.42(d, J=8.4Hz, 2H), 7.65(d, J=8.4Hz, 2H), 10.41(s, 1H) III-18 m.p. 88–89° C. ¹HNMR(CDCl₃) δ 2.20(s, 3H), 2.38(s, 3H), 3.19(s, 3H), 7.06(s, 1H), 7.33(s, 4H), 7.45(s, 1H) IR(KBr)1479, 1366, 1195, 1173, 1151, 970, 865, 850, 796cm⁻¹ III-19 m.p. 72–73° C. ¹HNMR(CDCl₃) δ 3.20(s, 3H), 7.20(dd, J=6.6, 8.4Hz, 1H), 7.35–7.44(m, 3H), 7.53–7.60(m, 2H) IR(KBr)1514, 1481, 1364, 1335, 1182, 1144, 979, 870, 798cm⁻¹ III-20 m.p. 144–146° C. ¹HNMR(CDCl₃) δ 3.45(s, 3H), 3.89(s, 3H), 4.99(brs, 2H), 6.19(s, 1H), 6.42(s, 1H), 6.88–6.94(m, 2H), 7.44–7.49(m, 2H) IR(KBr)3471, 3392, 29863, 1612, 1596, 1461, 1410, 1223, 1175, 1099, 1079, 1011cm⁻¹

TABLE 3 III-21 oil ¹HNMR(CDCl₃) δ 1.09(t, J=7.5Hz, 3H), 1.82–1.94(m, 2H), 3.58(s, 3H), 3.86(s, 3H), 4.06(t, J=6.6Hz, 2H), 6.63(s, 1H), 6.94–6.99(m, 2H), 7.44–7.49(m, 2H) IR(film): 3100–2800(br), 1609, 1583, 1513, 1466, 1423, 1401, 1378, 1291, 1249, 1232, 1178, 1127, 1097, 1034, 1012cm⁻¹ III-22 m.p. 83.5–84.5° C. ¹HNMR(CDCl₃) δ 3.20(br, 1H), 3.54(s, 3H), 3.85–3.90(m, 2H), 3.86(s, 3H), 3.90(s, 3H), 4.29–4.32(m, 2H), 6.66(s, 1H), 6.95–7.00(m, 2H), 7.45–7.50(m, 2H) IR(KBr)3600–2800(br), 1608, 1583, 1513, 1467, 1441, 1421, 1398, 1365, 1290, 1247, 1178, 1133, 1097, 1079, 1028, 1007cm⁻¹ III-23 m.p. 99–101° C. ¹HNMR(CDCl₃) δ 3.20(s, 3H), 3.39(s, 3H), 3.91(s, 3H), 3.99(s, 3H), 6.89(s, 1H), 7.37(d, J=8.7Hz, 2H), 7.64(d, J=8.7Hz, 2H) IR(KBr)1747, 1466, 1367, 1348, 1153, 1059, 968, 859, 794cm⁻¹ III-24 ¹HNMR(CDCl₃) δ 3.22(s, 3H), 3.45(s, 3H), 3.94(s, 3H), 7.04(s, 1H), 7.32–7.43(m, 2H), 7.58–7.69(m, 2H), 10.42(s, 1H) III-25 ¹HNMR(CDCl₃) δ 2.46(broad, 1H), 3.21(s, 3H), 3.43(s, 3H), 3.90(s, 3H), 4.94(s, 2H), 6.83(s, 1H), 7.42–7.51(m, 2H), 7.57–7.68(m, 2H) III-26 m.p. 109–110° C. ¹HNMR(CDCl₃) δ 1.97(br, 1H), 3.21(t, J=6.6Hz, 2H), 3.86(s, 3H), 3.89(s, 3H), 3.90(t, J=6.9Hz, 2H), 6.76(s, 1H), 6.95–7.00(m, 2H), 7.49– 7.53(m, 2H) IR(KBr)3600–2800(br), 1609, 1581, 1511, 1462, 1441, 1426, 1385, 1289, 1250, 1237, 1179, 1116, 1078, 1046, 1031, 1005cm⁻¹ III-27 foam ¹HNMR(CDCl₃) δ 1.52(s, 9H), 3.20(s, 3H), 3.41(s, 3H), 3.90(s, 3H), 6.16(s, 1H), 6.76(s, 1H), 7.35(d, J=8.7Hz, 2H), 7.61(d, J=8.7Hz, 2H) IR(KBr)3371, 1718, 1505, 1497, 1367, 1241, 1151, 872cm⁻¹

TABLE 4 III-28 m.p. 167–170° C. ¹HNMR(CDCl₃) δ 2.73(s, 3H), 3.74(s, 3H), 3.92(s, 3H), 7.08–7.17(m, 3H), 7.31–7.36(m, 2H) IR(CHCl₃)2934, 1593, 1560, 1512, 1477, 1436, 1411, 1372, 1157, 1107, 1076, 997, 958, 892, 839, 815cm⁻¹ III-29 m.p. 140–142° C. ¹HNMR(CDCl₃) δ 3.27(s, 3H), 3.79(s, 3H), 3.90(s, 3H), 6.86(s, 1H), 6.97(s, 1H), 7.29(ddd, J=8.4, 2.2, 0.9Hz, 1H), 7.39(dd, J=11.0, 2.2Hz, 1H), 7.43(t, J=8.4Hz, 1H) IR(KBr)1504, 1421, 1344, 1225, 1208, 916, 824cm⁻¹ III-30 ¹HNMR(CDCl₃) δ 3.77(s, 3H), 3.91(s, 3H), 3.95(s, 3H), 6.87(s, 1H), 7.01(s, 1H), 7.56(d, J=8.1Hz, 2H), 8.09(d, J=8.1Hz, 2H) III-31 ¹HNMR(CDCl₃) δ 3.78(s, 3H), 3.91(s, 3H), 6.88(s, 1H), 6.97(s, 1H), 7.60(d, J=8.1Hz, 2H), 7.7(d, J=8.1Hz, 2H) III-32 m.p. 147–148° C. ¹HNMR(CDCl₃) δ 3.79(s, 3H), 3.92(s, 3H), 6.89(s, 1H), 7.01(s, 1H),7.64–7.69(m, 2H), 8.26–8.31(m, 2H) IR(KBr)3600–2800(br), 1595, 1511, 1490, 1422, 1354, 1249, 1215, 1145, 1106, 1032cm⁻¹ III-33 ¹HNMR(CDCl₃) δ 3.31(s, 3H), 3.53(s, 3H), 3.94(s, 3H), 7.19(s, 1H), 7.39(ddd, J=8.3, 2.3, 1.0Hz, 1H), 7.39(dd, J=10.3, 2.3Hz, 1H), 7.43(t, J=8.31Hz, 1H), 10.40(s, 1H) III-34 ¹HNMR(CDCl₃) δ 0.13(s, 6H), 0.97(s, 9H), 2.51(s, 3H), 3.73(s, 3H), 3.93(s, 3H), 5.09(s, 2H), 6.84–6.99(m, 2H), 6.89(s, 1H), 7.05(s, 1H), 7.29–7.48(m, 5H) III-35 m.p. 124–128° C. ¹HNMR(CDCl₃) δ 2.62(s, 3H), 3.74(s, 3H), 3.91(s, 3H), 5.19(s, 2H), 7.00–7.18(m, 4H), 7.30–7.49(m, 5H) IR(CHCl₃)2930, 1607, 1517,1480, 1369, 1148, 1118, 1082, 1025, 969, 872cm⁻¹

TABLE 5 III-36 oil ¹HNMR(CDCl₃) δ 0.13(s, 6H), 0.96(s, 3H), 3.01(s, 3H), 3.69(s, 3H), 3.86(s, 3H), 4.81(s, 2H), 5.08(s, 2H), 6.88–6.94(m, 3H), 7.30–7.47(m, 5H) IR(KBr)3023, 2932, 2858, 1579, 1512, 1471, 1381, 1264, 1120, 1083cm⁻¹ III-37 oil ¹HNMR(CDCl₃) δ 0.78(t, J=7.5Hz, 3H), 1.03–1.25(m, 2H), 1.38–1.47(m, 2H), 3.68–3.72(m, 2H), 3.70(s, 3H), 3.86(s, 6H), 5.15(s, 2H), 5.6 3(s, 1H), 6.81(dd, J=1.8, 8.4Hz, 1H), 6.86(s, 1H), 6.95–6.97(m, 2H), 7.36–7.46(m, 5H) IR(CH₃Cl): 3543, 3200–2800(br), 1587, 1511, 1465, 1412, 1376, 1285, 1248, 1118, 1081, 1031cm⁻¹ III-38 m.p. 104–105° C. ¹HNMR(CDCl₃) δ 3.11(s, 3H), 3.77(s, 3H), 3.90(s, 3H), 5.17(s, 2H), 6.84(s, 1H), 6.98(s, 1H), 7.11(d, J=8.7Hz, 1H), 7.37–7.48(m, 6H), 7.5 1(d, J=2.4Hz, 1H) IR(KBr)3600–2800(br), 1503, 1420, 1389, 1364, 1246, 1215, 1185, 1132, 1117, 1097, 1030cm⁻¹ III-39 m.p. 134–136° C. ¹HNMR(CDCl₃) δ 3.78(s, 3H), 3.91(s, 3H), 5.29(s, 2H), 6.86(s, 1H), 6.97(s, 1H), 7.17(d, J=8.7Hz, 1H), 7.31–7.51(m, 7H), 7.63(dd, J=2.4, 8.7Hz, 1H), 8.01(d, J=2.4Hz, 1H) IR(KBr)3434, 1620, 1532, 1494, 1413, 1280, 1222, 1206, 1133, 1108, 1037cm⁻¹ III-40 m.p. 100–101° C. ¹HNMR(CDCl₃) δ 3.55(s, 3H), 3.77(s, 3H), 3.90(s, 3H), 5.26(s, 2H), 6.84(s, 1H), 6.97(s, 1H), 7.16–7.31(m, 3H) IR(KBr)3600–2800(br), 1524, 1503, 1449, 1401, 1380, 1268, 1246, 1222, 1200, 1156, 1126, 1098, 1078, 1030cm⁻¹ III-41 m.p. 109–110° C. ¹HNMR(CDCl₃) δ 1.54(s, 9H), 3.76(s, 3H), 3.90(s, 3H), 6.75(br, 1H), 6.84(s, 1H), 6.97(s, 1H), 7.21–7.29(m, 2H), 8.13(t, J=8.7Hz, 1H) IR(KBr)3600–2800(br), 1720, 1593, 1531, 1509, 1427, 1393, 1245, 1223, 1214, 1201, 1162, 1137, 1105, 1029cm⁻¹

TABLE 6 III-42 foam ¹HNMR(CDCl₃) δ 2.36(s, 3H), 3.74(s, 3H), 3.88(s, 3H), 6.69(dd, J=0.6, 3.6Hz, 1H), 6.85(s, 1H), 6.99(s, 1H), 7.24–7.27(m, 2H), 7.23(dd, J=1.8,8.7Hz, 1H), 7.60(d, J=3.6Hz, 1H), 7.64(d, J=1.2Hz, 1H), 7.80–7.83(m, 2H), 8.02(d, J=8.4Hz, 1H) IR(KBr)3600–2800(br), 1508, 1463, 1444, 1421, 1373, 1246, 1216, 1176, 1132, 1093, 1038cm⁻¹ III-43 foam ¹HNMR(CDCl₃) δ 3.14(s, 3H), 3.51(s, 3H), 3.93(s, 3H), 5.20(s, 2H), 7.17(d, J=8.4Hz, 1H), 7.20(s, 1H), 7.38(m, 6H), 7.59(d, J=1.8Hz, 1H), 10.40(s, 1H) IR(CHCl₃)2941, 1703, 1613, 1603, 1580, 1513, 1475, 1426, 1372, 1295, 1264, 1169, 1137, 1112, 1088, 1044, 971, 954, 932, 838cm⁻¹ III-44 ¹HNMR(CDCl₃) δ 0.20(s, 6H), 0.13(s, 6H), 0.77(s, 9H), 0.97(s, 9H), 3.73(s, 3H), 3.83(s, 3H)), 5.08(s, 2H), 6.06(s, 2H), 6.88–6.96(m, 3H), 7.01 (s, 1H), 7.30–7.49(m, 5H) III-45 mp 106–108° C. ¹HNMR(CDCl₃) δ 3.21(s, 3H), 3.43(s, 3H), 3.94(s, 3H), 5.87(s, 1H), 7.39(d, J=9.0Hz, 2H), 7.55(d, J=9.0Hz, 2H) IR(KBr)3410, 1460, 1422, 1362, 1146, 1037, 874, 915, 787cm⁻¹ III-46 mp 123–124° C. ¹HNMR(CDCl₃) δ 2.48(brs, 1H), 3.21(s, 3H), 3.43(s, 3H), 3.94(s, 3H), 4.93(brs, 2H), 6.83(s, 1H), 7.37(d, J=9.0Hz, 2H), 7.63(d, J=9.0Hz, 2H) IR(KBr)3524, 1463, 1352, 1233, 1152, 1009, 979, 869cm⁻¹ III-47 mp 107–109° C. ¹HNMR(CDCl₃) δ 1.93(s, 6H), 2.45(s, 6H), 4.75(brs, 1H), 6.87–6.96(m, 4H) IR(KBr)3367, 1612, 1509, 1433, 1214, 990, 824cm⁻¹

TABLE 7 III-48 oil ¹HNMR(CDCl₃) δ 1.14(t, J=6.9Hz, 3H), 1.46(t,J=6.9Hz, 3H), 3.58(q, J=6.9Hz, 2H), 3.58(q, J=6.9Hz, 2H), 6.19(s, 1H), 6.41(s, 1H), 6.86–6.92(m, 2H), 7.43–7.49(m, 2H) IR(CHCl₃)3688, 3594, 3502, 2982, 1612, 1517, 1172, 1080, 1026, 925cm⁻¹ III-49 ¹HNMR(CDCl₃) δ 0.02(s, 6H), 0.12(s, 6H), 0.90(s, 9H), 0.93(s, 9H), 4.54(s, 2H), 4.76(s, 2H), 6.84–6.89(m, 2H), 7.16–7.22(m, 2H), 7.37(s, 1H), 7.69(s, 1H) III-50 mp173–175° C. ¹HNMR(CDCl₃) δ 3.21(s, 3H), 3.47(s, 3H), 3.89(s, 3H), 6.15(s, 1H), 6.42(s, 1H), 7.24–7.37(m, 2H), 7.61–7.66(m, 2H) IR(KBr)3408, 2934, 1604, 1480, 1360, 1146, 1089, 1004, 865, 709, 547cm⁻¹ III-51 mp156–158° C. ¹HNMR(CDCl₃) δ 3.21(s, 3H), 3.39(s, 3H), 3.90(s, 3H), 6.05(s, 1H), 7.36–7.44(m, 4H) IR(KBr)3410, 2938, 1505, 1457, 1413, 1337, 1194, 1143, 1084, 1014, 876, 826, 542, 519cm⁻¹ III-52 mp181–183° C. ¹HNMR(CDCl₃) δ 3.19(s, 3H), 3.88(s, 3H), 4.21–4.24(m, 2H), 4.39–4.42(m, 2H), 6.49(s, 1H), 7.45(ABq, J=8.7Hz, 4H) IR(KBr)3435, 1598, 1505, 1474, 1425, 1366, 1178, 1147, 1113cm⁻¹ III-53 mp155–157° C. ¹HNMR(CDCl₃) δ −0.11–0.02(m, 2H), 0.33–0.44(m, 2H), 0.91(m, 1H), 3.20(s, 3H), 3.41(d, J=7.0Hz, 2H), 3.50(s, 3H), 3.92(s, 3H), 6.88(s, 1H), 7.51(ABq, J=8.6Hz, 4H) IR(KBr)3434, 1505, 1472, 1416, 1386, 1371, 1357, 1242, 1179, 1149, 1084cm⁻¹ III-54 mp105–107° C. ¹HNMR(CDCl₃) δ 3.20(s, 3H), 3.39(s, 3H), 3.89(s, 3H), 4.77(s, 2H), 6.40(s, 1H), 7.33–7.55(m, 5H) IR(KBr)3411, 1592, 1572, 1507, 1482, 1467, 1437, 1360, 1339, 1232, 1204, 1175, 1148, 1125, 1092cm⁻¹

TABLE 8 III-55 mp 138–140° C. ¹HNMR(CDCl₃) δ 1.14(t, J=7.0Hz, 3H), 3.59(q, J=7.0Hz, 2H), 3.88(s, 3H), 4.97(bs, 1H), 6.42(s, 1H), 6.86–6.94(m, 2H), 7.43–7.51(m,2H) IR(KBr)3384, 3291, 2978, 1614, 1593, 1576, 1519, 1484, 1469, 1455, 1436, 1417, 1366, 1306, 1285, 1257, 1203, 1171, 1127, 1094, 1029cm⁻¹ III-56 mp 162–164° C. ¹HNMR(CDCl₃) δ 2.77(s, 3H), 3.17(s, 3H), 3.75(s, 3H), 3.92(s, 3H), 7.10(s, 2H), 7.35–7.43(m, 4H) IR(CHCl₃)1594, 1561, 1507, 1478, 1464, 1374, 1331, 1178, 1149, 1109, 1080, 1000, 970, 894, 871, 844cm⁻¹ III-57 mp 95–97° C. ¹HNMR(CDCl₃) δ 2.35(s, 3H), 3.77(s, 3H), 6.84–6.87(m, 2H), 7.12(s, 1H), 7.13(s, 1H), 7.35–7.38(m, 2H) IR(CHCl₃)3596, 2959, 2939, 2840, 1611, 1563, 1517, 1489, 1464, 1438, 1384, 1367, 1329, 1295, 1258, 1173, 1102, 1049, 1035, 1001, 911, 891, 835cm⁻¹ III-58 mp 173–175° C. ¹HNMR(CDCl₃) δ 6.91–6.94(m, 2H), 7.31–7.34(m, 2H), 7.87(s, 1H), 8.09(s, 1H), 9.89(s, 1H), 10.28(s, 1H) IR(CHCl₃)3437, 1685, 1610, 1516, 1456, 1394, 1370, 1270, 1261, 1238, 1214, 1173, 1144, 1053, 1012, 939, 905, 829, 808, 557, 458cm⁻¹ III-59 mp 173–175° C. ¹HNMR(CDCl₃) δ 1.10(t, J=6.9Hz, 3H), 1.48(t, J=6.9Hz, 3H), 3.20(s, 3H), 3.47(s, 3H), 3.66(q, J=6.9Hz, 2H), 4.11(q, J=6.9Hz, 2H), 6.79(s, 1H), 7.32–7.39(m, 2H), 7.60–7.66(m, 2H) IR(CHCl₃)1502, 1458, 1372, 1176, 1148, 1074, 1023, 967, 870cm⁻¹ III-60 ¹HNMR(CDCl₃) δ 2.17(s, 3H), 2.39(s, 3H), 3.19(s, 3H), 5.80(s, 1H), 6.71(s, 1H), 7.33(s, 4H)

TABLE 9 III-61 mp 107–108° C. ¹HNMR(CDCl₃) δ 3.21(s, 3H), 3.79(s, 3H), 4.04(s, 3H), 7.39(d, J=8.9Hz, 2H), 7.57(d, J=8.9Hz, 2H), 7.68(s, 1H), 10.17(s, 1H) IR(KBr)1704, 1422, 1358, 1224, 1148, 1090, 1026, 974, 876cm⁻¹ III-62 mp 121–122° C. ¹HNMR(CDCl₃) δ 3.45(s, 3H), 3.47(s, 3H), 3.93(s, 3H), 4.68(s, 2H), 4.77(s, 2H), 7.22(s, 1H), 7.49(d, J=8.1Hz, 2H), 7.56(d, J=8.1Hz, 2H), 10.42(s, 1H) IR(KBr)1695, 1476, 1422, 1232, 1189, 1130, 1040, 860cm⁻¹ III-63 mp 113–115° C. ¹HNMR(CDCl₃) δ 2.18(s, 3H), 3.22(s, 3H), 3.89(s, 3H), 6.85(s, 1H), 7.11(s, 1H), 7.36(s, 4H) IR(KBr)1497, 1413, 1354, 1230, 1146, 1097, 976, 864cm⁻¹ III-64 ¹HNMR(CDCl₃) δ 5.65(s, 1H), 7.18(s, 1H), 7.30–7.35(m, 2H), 7.46–7.50(m, 3H) III-65 ¹HNMR(CDCl₃) δ 1.30(d, J=7.2Hz, 6H), 2.96(quintet, J=7.2Hz, 1H), 3.82(s, 3H), 3.91(s, 3H), 5.92(brs, 2H), 6.91(s, 1H), 7.30(d, J=8.1Hz, 2H), 7.44(s, 1H), 7.49(d, J=8.1Hz, 2H) III-66 mp 118–122° C. ¹HNMR(CDCl₃) δ 3.80(s, 3H), 3.91(s, 3H), 5.88(s, 2H), 6.84–6.92(m, 3H), 7.39–7.47(m, 3H) IR(KBr)3600–2800(br), 1606, 1517, 1492, 1461, 1415, 1397, 1330, 1265, 1205, 1171, 1052cm⁻¹ III-67 mp 227–230° C. ¹HNMR(CDCl₃) δ 0.25(s, 6H), 1.02(s, 9H), 2.33(s, 3H), 2.82(s, 2H), 6.88–6.93(m, 2H), 7.16(s, 1H), 7.21–7.25(m, 3H), 8.11(s, 1H) IR(KBr)3600–2800(br), 1608, 1514, 1393, 1346, 1267, 1167cm⁻¹ III-68 mp 134–137° C. ¹HNMR(CDCl₃) δ 3.00(s, 6H), 3.81(s, 3H), 3.91(s, 3H), 6.00(s, 2H), 6.77–6.82(m, 2H), 6.90(s, 1H), 7.41(s, 1H), 7.46–7.51(m, 3H) IR(KBr)3600–2800(br), 1601, 1528, 1494, 1466, 1439, 1399, 1362, 1321, 1198, 1166, 1118, 1051cm⁻¹

TABLE 10 III-69 mp 144–148° C. ¹HNMR(CDCl₃) δ 2.38(s, 3H), 2.82(s, 3H), 3.01(s, 6H), 7.79–7.83(m, 2H), 7.18(s, 1H), 7.27–7.31(m, 2H), 8.11(s, 1H) IR(KBr)3600–2800(br), 1612, 1523, 1443, 1389, 1328, 1271, 1160cm⁻¹ III-70 mp 122–126° C. ¹HNMR(CDCl₃) δ 0.10(s, 9H), 0.78(s, 6H), 2.96(s, 6H), 3.75(s, 3H), 3.84(s, 3H), 6.08(s, 2H), 6.72–6.78(m, 2H), 7.01(s, 1H), 7.22–7.29(m, 2H) IR(KBr)3600–2800(br), 1613, 1528, 1463, 1416, 1402, 1360, 1345, 1251, 1218, 1195, 1136, 1092, 1062, 991cm⁻¹ III-71 ¹HNMR(CDCl₃) δ 2.21(s, 3H), 2.37(s, 3H), 3.89(s, 3H), 5.19(s, 2H), 6.75(d.d, J=8.4&2.1Hz, 1H), 6.81(d, J=2.1Hz, 1H), 6.92(d, J=8.4Hz, 1H), 7.08(s, 1H), 7.30–7.50(m, 6H) III-72 oil ¹HNMR(CDCl₃) δ 2.51(s, 6H), 2.75(s, 6H), 5.15(s, 2H), 5.67(s, 1H), 6.94(s, 1H), 6.96(d, J=8.4Hz, 1H), 7.04(dd, J=2.1, 8.4Hz, 1H), 7.18(s, 1H), 7.20(d, J=2.1Hz, 1H), 7.37–7.47(m, 5H) IR(CHCl₃)3032, 3428, 3000–2800(br), 1730, 1611, 1525, 1489, 1455, 1256, 1171, 1137, 1100, 1036cm⁻¹ III-73 ¹HNMR(CDCl₃) δ 2.21(s, 3H), 2.37(s, 3H), 5.15(s, 2H), 5.69(br, 1H), 6.73(dd, J=8.4, 1.8Hz, 1H), 6.89–6.99(m, 2H), 7.07(s, 1H), 7.26–7.4 6(m, 6H) III-74 ¹HNMR(CDCl₃) δ 1.09(t, J=7.2Hz, 3H), 1.22(t, J=7.5Hz, 3H), 2.55(q, J=7.2Hz, 2H), 2.72(q, J=7.5Hz, 2H), 5.15(s, 2H), 5.70(s, 1H), 6.73(dd, J=8.4, 1.8Hz, 1H), 6.89(d, J=1.8Hz, 1H), 6.95(d, J=8.4Hz, 1H), 7.04(s, 1H), 7.38–7.47(m, 6H) IR(CHCl₃)3542, 2970, 2933, 1586, 1508, 1480, 1384, 1324, 1290, 1160, 1127, 1064, 1011, 930, 898, 879, 857cm⁻¹ III-75 ¹HNMR(CDCl₃) δ 2.04(s, 3H), 3.70(s, 3H), 3.90(s, 3H), 5.19(s, 2H), 5.50(m, 1H), 6.73(dd, J=2.1Hz, 1H), 6.97–7.00(m, 2H), 7.29–7.48(m, 5H)

TABLE 11 III-76 ¹HNMR(CDCl₃) δ 2.04(s, 3H), 3.90(s, 3H), 5.15(s, 2H), 5.49(s, 1H), 5.74(s, 1H), 6.71(dd, J=8.1, 2.1Hz, 1H), 6.85(d, J=2.1Hz, 1H), 6.99–7.03 (m, 2H), 7.39–7.45(m, 5H) IR(CHCl₃)3529, 2963, 2940, 1731, 1587, 1566, 1510, 1480, 1455, 1412, 1382, 1323, 1290, 1248, 1128, 1099, 1009, 935, 879cm⁻¹ III-77 mp 87–89° C. ¹HNMR(CDCl₃) δ 2.20(s, 3H), 2.37(s, 3H), 5.18(s, 2H), 6.90–7.10(m, 4H), 730–7.51(m, 6H) IR(CHCl₃)1510, 1482, 1381, 1298, 1267, 1233, 1127, 1008, 952, 875, 812cm⁻¹ III-78 ¹HNMR(CDCl₃) δ 1.25(d, J=6.9Hz, 6H), 2.24(s, 3H), 3.26(sept, J=6.9Hz, 1H), 5.20(s, 2H), 6.95(ddd, J=8.3, 2.2, 1.2Hz, 1H), 7.06(t, J=8.3Hz, 1H), 7.06(dd, J=11.9, 2.2Hz, 1H), 7.10(s, 1H), 7.17(s, 1H), 7.32–7.51(m, 5H) IR(KBr)1492, 1420, 1228, 1203, 1140, 1012, 989, 841cm⁻¹ III-79 ¹HNMR(CDCl₃) δ 2.43(s, 3H), 5.19(s, 2H), 7.06(t, J=8.9Hz, 1H), 7.18–7.48(m, 10H) IR(KBr)1491, 1437, 1214, 1135, 890, 810, 748cm⁻¹ III-80 mp 77–79° C. ¹HNMR(CDCl₃) δ 3.921(s, 3H), 5.21(s, 2H), 6.90–6.99(m, 3H), 7.31–7.50(m, 7H) IR(KBr)3600–2800(br), 1518, 1477, 1418, 1237, 1212, 1167, 1140cm⁻¹ III-81 mp 103–105° C. ¹HNMR(CDCl₃) δ 2.16(s, 3H), 2.37(s, 3H), 2.42(s, 3H), 3.16(m, 3H), 5.21(s, 2H), 7.16–7.17(m, 3H), 7.24–7.27(m, 1H), 7.36–7.48(m, 5H) IR(CHCl₃)2940, 1613, 1514, 1478, 1455, 1423, 1366, 1331, 1292, 1264, 1176, 1140, 1126, 1096, 1045, 1009, 972, 955, 920, 843cm⁻¹ III-82 ¹HNMR(CDCl₃) δ 2.19(s, 3H), 3.88(s, 3H), 5.20(s, 2H), 6.84(s, 1H), 6.95(m, 1H), 7.03–7.05(m, 3H), 7.35–7.49(m, 5H) III-83 mp 83–85° C. ¹HNMR(CDCl₃) δ 2.19(s, 3H), 3.88(s, 3H), 3.91(s, 3H), 5.21(s, 3H), 6.76(dd, J=8.4, 2.1Hz, 1H), 6.82(d, J=2.1Hz, 1H), 6.87(s, 1H), 6.93(d, J=8.4Hz, 1H), 7.08(s, 1H), 7.32–7.50(m, 5H) IR(CHCl₃)2962, 2937, 1613, 1579, 1499, 1464, 1455, 1443, 1421, 1319, 1249, 1170 1140, 1103, 1029, 1008, 989, 901, 832cm⁻¹

TABLE 12 III-84 oil ¹HNMR(CDCl₃) δ 1.44(d, J=6.9Hz, 3H), 2.19(s, 3H), 4.09(q, J=6.9Hz, 2H), 5.20(s, 2H), 6.82(s, 1H), 6.94–7.08(m, 3H), 7.32–7.49(m, 6H) IR(CHCl₃)3597, 2928, 1731, 1609, 1523, 1494, 1476, 1387, 1298, 1261, 1173, 1127, 1048, 834cm⁻¹ III-85 ¹HNMR(CDCl₃) δ 2.26(s, 3H), 2.52(s, 3H), 3.90(s, 3H), 4.59(brs, 2H), 5.20(s, 2H), 6.73–7.10(m, 4H), 7.27–7.52(m, 6H) III-86 ¹HNMR(CDCl₃) δ 2.33(s, 3H), 2.81(s, 3H), 4.60(brs, 2H), 5.20(s, 2H), 6.92–7.18(m, 4H), 7.30–7.52(m, 6H)

TABLE 13 I-1 m.p. 155.5–156° C. ¹HNMR(acetone-d₆) δ 1.77(brs, 3H), 1.79(brs, 3H), 3.37(s, 3H), 3.73(s, 3H), 4.63(brd, J=6.6Hz, 2H), 5.52(m, 1H), 6.49(1H, s), 6.83(d d, J=2.2 and 8.2Hz, 1H), 6.92(d, J=2.2Hz, 1H), 6.94(m, 2H), 6.96(d, J=8.2Hz, 1H), 7.54(m, 2H), 7.62(brs, 1H), 7.78(s, 1H), 8.64(brs, 1H) IR(KBr)3393, 2932, 1611, 1588, 1522, 1490, 1117, 1071, 1001cI-3 m⁻¹ I-2 ¹HNMR(CDCl₃) δ 2.67(s, 3H), 3.13(s, 3H), 3.21(s, 3H), 3.56(s, 3H), 3.78(s, 3H ), 5.19(s, 2H), 6.84(s, 1H), 7.15(d, J=8.6Hz, 1H), 7.30–7.50 (m, 9H), 7.60–7.75(m, 2H) IR(KBr)1373, 1361, 1179, 1149, 1079, 874, 799cm⁻¹ I-3 m.p. 155–157° C. ¹HNMR(CDCl₃) δ 1.76(s, 3H), 1.81(s, 3H), 2.71(s, 3H), 3.21(s, 3H), 3.23(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 4.64(d, J=6.6Hz, 2H), 5.43–5.55 (m, 1H), 6.84(s, 1H), 7.09(d, J=8.4Hz, 1H), 7.30–7.42(m, 4H), 7.65–7.75(m, 2H) IR(KBr)1519, 1481, 1364, 1179, 1153, 1083, 970, 877, 796cm⁻¹ I-4 ¹HNMR(CDCl₃) δ 3.45(s, 3H), 3.75(s, 3H), 5.16(s, 2H), 6.44(s, 1H), 6.92–7.19(m, 5H), 7.34–7.44(m, 5H), 7.57–7.66(m, 2H) IR(KBr)3538, 3510, 3460, 3330, 1605, 1521, 1490, 1455, 1247, 1220, 1120, 1070, 1010cm⁻¹ I-5 m.p. 136–138° C. ¹HNMR(CDCl₃) δ 2.68(s, 3H), 3.13(s, 3H), 3.55(s, 3H), 3.80(s, 3H)5.19(s, 2H), 6.86(s, 1H), 7.16(d, J=8.7Hz, 1H), 7.33–7.49(m, 7H), 7.55–7.69 (m, 2H), 7.82–7.87(m, 2H) IR(KBr)3433, 2937, 1609, 1519, 1474, 1463, 1364, 1322, 1295, 1274, 1235, 1183, 1167, 1120, 1095, 1077, 1016cm⁻¹ I-6 foam ¹HNMR(CDCl₃) δ 1.77(s, 3H), 1.81(s, 3H), 2.72(s, 3H), 3.24(s, 3H), 3.49(s, 3H), 3.80(s, 3H), 4.64(d, J=6.9Hz, 2H), 5.50(m, 1H), 6.86(s, 1H), 7.10(d, J=8.7Hz, 1H), 7.35(dd, J=2.1, 8.7Hz, 1H), 7.39(d, J=2.1Hz, 1H), 7.55–7.69(m, 2H), 7.82–7.87(m, 2H). IR(CHCl₃)3030, 1608, 1518, 1480, 1369, 1322, 1269, 1230, 1179, 1131, 1120, 1097, 1081, 1015cm⁻¹

TABLE 14 I-7 m.p. 92–94° C. ¹HNMR(CDCl₃) δ 1.76(s, 3H), 1.82(s, 3H), 3.46(s, 3H), 3.77(s, 3H), 4.62(d, J=6.9Hz, 2H), 5.31(m, 1H), 5.71(s, 1H), 5.85(s, 1H), 6.47(s, 1H), 6.93(dd, J=1.8, 8.7Hz, 1H), 6.97(d, J=8.7Hz, 1H), 7.05(d, J=1.8Hz, 1H), 7.55–7.65(m, 2H), 7.83–7.91(m, 2H). IR(KBr)3466, 2939, 1609, 1587, 1518, 1498, 1486, 1464, 1437, 1406, 1361, 1324, 1245, 1216, 1155, 1125, 1073cm⁻¹ I-8 ¹HNMR(CDCl₃) δ 3.22(s, 3H), 3.45(s, 3H), 3.77(s, 3H), 4.74(s, 2H), 5.15(s, 2H), 6.93(s, 1H), 7.01(d, J=8.7Hz, 2H), 7.32–7.48(m, 9H), 7.73 (d, J=9.0Hz, 2H) IR(KBr)3400, 1721, 1612, 1509, 1471, 1362, 1242, 1153, 1040, 1018cm⁻¹ I-9 ¹HNMR(CDCl₃) δ 1.03(t, J=7.2Hz, 3H), 2.16(dq, J=7.2, 6.0Hz, 2H), 3.46(s, 3H), 3.74(s, 3H), 4.68(d, J=5.4Hz, 2H), 5.70(m, 2H), 6.45 (s, 1H), 6.91(d, J=8.7Hz, 2H), 6.96(brs, 2H), 7.07(brs, 1H), 7.53(d, J=8.7Hz, 2H) IR(Nujol)3445, 3369, 1612, 1578, 1523, 1489, 1268, 1243, 1112, 1102, 1071, 1011, 998, 944, 824, 805, 781cm⁻¹ I-10 m.p. 174–175° C. ¹HNMR(CDCl₃) δ 3.11(s, 3H), 3.21(s, 3H), 3.45(s, 3H), 3.73(s, 3H), 4.49(brs, 2H), 5.18(s, 2H), 6.85(s, 1H), 7.15(d, J=8.4Hz, 1H), 7.27 (dd, J=8.4Hz, J=2.1Hz, 1H), 7.35–7.49(m, 8H), 7.70(m, 2H) IR(KBr)1519, 1467, 1360, 1346, 1331, 1295, 1272, 1229, 1180, 1151, 1122, 1101, 1081, 1022, 980, 971, 954, 875, 849, 814, 798, 742, 525cm⁻¹ I-11 ¹HNMR(CDCl₃) δ 1.77(s, 3H), 1.82(s, 3H), 3.22(s, 6H), 3.45(s, 3H), 3.74(s, 3H), 4.49(brs, 2H), 4.64(d, J=7.2Hz, 2H), 5.45–5.55(m, 1H), 6.85(s, 1H), 7.08(d, J=8.7Hz, 1H), 7.26(dd, J=8.7 and 2.1Hz, 1H), 7.33(d, J=2.1Hz, 1H), 7.36–7.41(m, 2H), 7.65–7.75(m, 2H) IR(KBr)3553, 3434, 1516, 1472, 1365, 1176, 1150, 973, 871cm⁻¹ I-12 ¹HNMR(DMSO-d₆) δ 1.72(s, 3H), 1.77(s, 3H), 3.35(s, 3H), 3.65(s, 3H), 4.20(brs, 2H), 4.47(brt, J=4.4Hz, 1H), 4.55(brd, J=6.6Hz, 2H), 5.40–5.57(m, 1H), 6.64(dd, J=8.2, 2.0Hz, 1H), 6.70(d, J=2.0Hz, 1H), 6.75–7.00(m, 4H), 7.40–7.55(m, 2H) IR(KBr)3435, 1518, 1475, 1459, 1261, 1223, 988cm⁻¹

TABLE 15 I-13 ¹HNMR(CDCl₃) δ 2.71(s, 3H), 2.84(s, 3H), 3.20(s, 3H), 3.42(s, 3H), 3.76(s, 3H), 5.13(s, 2H), 5.67(s, 1H), 6.90(s, 1H), 6.89–6.96(m, 2H), 7.00(m, J=1.8Hz, 1H), 7.32–7.50(m, 7H), 7.70(d, J=9.0Hz, 2H) I-14 m.p. 140–141° C. ¹HNMR(CDCl₃) δ 2.71(s, 3H), 2.83(s, 3H), 3.15(s, 3H), 3.21(s, 3H), 3.42(s, 3H), 3.77(s, 3H), 5.16(s, 2H), 6.90(s, 1H), 7.09(d, J=8.9Hz, 2H), 7.30–7.50(m, 9H), 7.70(d, J=8.9Hz, 2H) IR(KBr)1642, 1516, 1467, 1362, 1180, 1151, 1118, 1050, 867, 803, 708cm⁻¹ I-15 m.p. 161–162° C. ¹HNMR(CDCl₃) δ 1.76(s, 3H), 1.81(s, 3H), 2.72(s, 3H), 2.85(s, 3H), 3.21(s, 3H), 3.23(s, 3H), 3.42(s, 3H), 3.77(s, 3H), 4.61(d, J=6.6Hz, 2H), 5.49(t, J=6.6Hz, 1H), 6.90(S, 1H), 7.02(d, J=8.1Hz, 1H), 7.31–7.37(m, 2H), 7.38(d, J=8.9Hz, 2H), 7.70(d, J=8.9Hz, 2H) IR(KBr)1643, 1516, 1467, 1362, 1277, 1236, 1180, 1150, 974, 882, 868, 847, 802, 710cm⁻¹ I-16 m.p. 206–207° C. ¹HNMR(CDCl₃) δ 1.71(s, 3H), 1.76(s, 3H), 2.62(s, 3H), 2.69(s, 3H), 3.27(s, 3H), 3.71(s, 3H), 4.53(d, J=6.8Hz, 2H), 5.47(t, J=6.6Hz, 1H), 6.61(dd, J=8.3 and 2.1Hz, 1H), 6.71(d, J=2.1Hz, 1H), 6.86(d, J=8.7Hz, 2H), 6.87(d, J=8.3Hz, 1H), 6.95(s, 1H), 7.47(d, J=8.7Hz, 2H), 8.83 (brs, 1H), 9.59(brs, 1H) IR(KBr)3427, 3020, 1608, 1517, 1467, 1379, 1233, 1053, 1005, 839, 799, 759, 543cm⁻¹ I-17 m.p. 171–172° C. ¹HNMR(DMSO-d₆) δ 1.74(d, J=0.9Hz, 3H), 1.77(s, 3H), 2.97(s, 3H), 3.45(s, 3H), 3.51(s, 3H), 3.77(s, 3H), 4.65(d, J=6.6Hz, 2H), 5.48 (m, 1H), 7.06–7.27(m, 4H), 7.48&7.74(ABq, J=9.0Hz, 4H) IR(KBr)1523, 1483, 1394, 1366, 1271, 1175, 1151, 1087, 1071, 872, 861, 847, 796cm⁻¹ I-18 ¹HNMR(CDCl₃) δ 1.76(s, 3H), 1.80(s, 3H), 3.44(s, 3H), 3.76(s, 3H), 4.63(d, J=6.6Hz, 2H), 4.99(s, 1H), 5.48–5.62(m, 1H), 6.00(s, 1H), 6.45 (s, 1H), 6.88–6.97(m, 2H), 7.04(dd, J=9.0, 9.0Hz, 1H), 7.15–7.29(m, 2H), 7.45–7.60(m, 2H) IR(KBr)3393, 1523, 1490, 1466, 1403, 1267, 1229, 1113, 1070cm⁻¹

TABLE 16 I-19 ¹HNMR(CDCl₃) δ 2.56(s, 3H), 3.21(s, 3H), 3.52(s, 3H), 3.69(s, 3H), 5.19(s, 2H), 5.76(s, 1H), 6.92(dd, J=8.4 and 2.0Hz, 1H), 7.04(d, J=8.4Hz, 1H), 7.05(d, J=2.0Hz, 1H), 7.35–7.51(m, 7H), 7.60(d, J=8.6Hz, 2H) I-20 ¹HNMR(CDCl₃) δ 2.69(s, 3H), 3.14(s, 3H), 3.21(s, 3H), 3.53(s, 3H), 3.71(s, 3H), 5.20(s, 2H), 7.18(d, J=8.7Hz, 1H), 7.34–7.50(m, 9H), 7.59 (d, J=8.71Hz, 2H) I-21 m.p. 94–95° C. ¹HNMR(CDCl₃) δ 2.73(s, 3H), 3.21(s, 3H), 3.24(s, 3H), 3.53(s, 3H), 3.71(s, 3H), 4.65(d, J=6.9Hz, 2H), 5.50(t, J=6.9Hz, 1H), 7.12(d, J=8.6Hz, 1H), 7.36(dd, J=8.6 and 2.1Hz, 1H), 7.41(d, J=2.1Hz, 2H), 7.41(d, J=8.8Hz, 2H), 7.59(d, J=8.8Hz, 2H) IR(KBr)1516, 1367, 1180, 1152, 1039, 975, 869, 799cm⁻¹ I-22 m.p. 148–150° C. ¹HNMR(CDCl₃) δ 3.42(s, 3H), 3.65(s, 3H), 4.63(d, J=6.9Hz, 2H), 4.98(brs, 1H), 5.53(t, J=6.9Hz, 1H), 6.92–6.96(m, 4H), 7.07(s, 1H), 7.43 (d, J=8.6Hz, 2H) IR(KBr)3398, 1612, 1587, 1523, 1462, 1410, 1261, 1211, 1099, 1036, 984, 952, 919, 838, 815cm⁻¹ I-23 ¹HNMR(CDCl₃) δ 2.28(t, J=6.3Hz, 1H), 2.60(s, 3H), 3.21(s, 3H), 3.55(s, 3H), 3.77(s, 3H), 4.78(d, J=6.3Hz, 2H), 5.18(s, 2H), 6.84(s, 1H), 7.06(d, J=9.0Hz, 1H), 7.29–7.48(m, 9H), 7.69(d, J=8.7Hz, 2H) I-24 ¹HNMR(CDCl₃) δ 1.76(s, 3H), 1.81(s, 3H), 2.26(s, 3H), 2.50(s, 3H), 3.21(s, 3H), 3.56(s, 3H), 3.77(s, 3H), 4.57(d, J=6.2Hz, 2H), 5.51(t, J=6.2Hz, 1H), 6.83(s, 1H), 6.92(d, J=9.0Hz, 1H), 7.17–7.29(m, 2H), 7.36(d, J=8.7Hz, 2H), 7.70(d, J=8.7Hz, 2H) IR(KBr)3434, 1608, 1512, 1479, 1364, 1234, 1175, 1150, 1078, 1017cm⁻¹ I-25 ¹HNMR(CDCl₃) δ 1.75(s, 3H), 1.80(s, 3H), 2.27(s, 3H), 3.46(s, 3H), 3.74(s, 3H), 4.57(d, J=6.2Hz, 2H), 4.95(s, 1H), 5.53(t, J=6.2Hz, 1H), 5.86(s, 1H), 6.45(s, 1H), 6.91(d, J=8.7Hz, 2H), 6.92(d, J=9.0Hz, 1H), 7.24(d, J=9.0Hz, 1H), 7.26(s, 1H), 7.53(d, J=8.7Hz, 2H) IR(KBr)3399, 1612, 1566, 1581, 1520, 1486, 1237, 1115, 1078, 1001cm⁻¹

TABLE 17 I-26 m.p. 246–247° C. ¹HNMR(DMSO-d₆) δ 5.16(s, 3H), 6.84–6.87(m, 2H), 7.05(s, 2H), 7.14(s, 1H), 7.32–7.43(m, 3H), 7.49–7.64(m, 8H) IR(KBr)3600–3100(br), 1594, 1453, 1387, 1296, 1253, 1010cm⁻¹ I-27 ¹HNMR(DMSO-d₆) δ 3.38(s, 3H), 3.43(s, 3H), 5.28(s, 2H), 7.36–7.54(m, 8H), 7.69–7.86(m, 8H) IR(KBr)1488, 1354, 1286, 1178, 1151, 1116cm⁻¹ I-28 m.p. 162–163° C. ¹HNMR(CDCl₃) δ 1.77(s, 3H), 1.82(s, 3H), 3.19(s, 3H), 3.23(s, 3H), 4.64(d, J=6.6Hz, 2H), 5.25–5.48(m, 1H), 7.09(d, J=9.0Hz, 1H), 7.36–7.40 (m, 2H), 7.52(dd, J=2.4, 9.0Hz, 1H), 7.59(d, J=2.4Hz, 1H), 7.62(s, 4H), 7.63–7.69(m, 2H) IR(KBr)1489, 1363, 1290, 1177, 1154, 1115, 971, 860, 809cm⁻¹ I-29 m.p. 195° C. ¹HNMR(DMSO-d₆) δ 1.72(s, 3H), 1.75(s, 3H), 4.57(d, J=6.3Hz, 2H), 5.45–5.50(m, 1H), 6.84–6.87(m, 2H), 6.98–7.11(m, 3H), 7.50–7.64 (m, 6H) IR(KBr)3600–3200(br), 1609, 1594, 1497, 1257, 991cm⁻¹ I-30 m.p. 145–148° C. ¹HNMR(CDCl₃) δ 1.60–2.20(m, 6H), 2.72(s, 3H), 3.21(s, 3H), 3.24(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 4.92(m, 1H), 5.88(m, 1H), 6.02(m, 1H), 6.84(s, 1H), 7.12(d, J=8.6Hz, 1H), 7.34–7.40(m, 4H), 7.69(m, 2H) IR(KBr)1517, 1481, 1390, 1362, 1270, 1244, 1180, 1151, 1077, 1012, 973, 960, 873, 817, 799, 521cm⁻¹ I-31 m.p. 108–110° C. ¹HNMR(CDCl₃) δ 1.60–2.20(m, 6H), 3.46(s, 3H), 3.75(s, 3H), 4.86(m, 1H), 5.02(bs, 1H), 5.75(s, 1H), 5.90(m, 1H), 5.91(s, 1H), 6.00(m, 1H), 6.45(s, 1H), 6.90–7.07(m, 5H), 7.53(m, 2H) IR(KBr)3485, 1614, 1523, 1491, 1457, 1407, 1312, 1287, 1269, 1238, 1195, 1170, 1115, 1072, 1014cm⁻¹

TABLE 18 I-32 m.p. 188–190° C. ¹HNMR(CDCl₃) δ 2.69(s, 3H), 3.21(s, 3H), 3.26(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 4.84(m, 2H), 6.42(dt, J=15.6Hz, J=5.7Hz, 1H), 6.79(d, J=15.6Hz, 1H), 6.84(s, 1H), 7.15(d, J=8.4Hz, 1H), 7.28–7.43(m, 9H), 7.68(m, 2H) IR(KBr)1519, 1479, 1447, 1391, 1360, 1301, 1273, 1241, 1228, 1201, 1175, 1152, 1120, 1079, 1014, 974, 959, 947, 868, 819, 795, 777, 743, 521cm⁻¹ I-33 m.p. 157–159° C. ¹HNMR(CDCl₃) δ 3.46(s, 3H), 3.75(s, 3H), 4.81(m, 2H), 4.93(bs, 1H), 5.70(s, 1H), 5.91(s, 1H), 6.45(s, 1H), 6.46(dt, J=15.9Hz, J=6.0Hz, 1H), 6.76(d, J=15.9Hz, 1H), 6.90–7.09(m, 5H), 7.26–7.46(m, 5H), 7.54(m, 2H) IR(KBr)3466, 1611, 1522, 1489, 1461, 284, 1248, 1192, 1165, 1114, 1073cm⁻¹ I-34 m.p. 127–129° C. ¹HNMR(CDCl₃) δ 1.03 and 1.04(botht, bothJ=8.0Hz, total3H), 2.07–2.19(m, 2H), 2.71 and 2.72(boths, total3H), 3.21(s, 3H), 3.24(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 4.60 and 4.71(bothm, total2H), 5.66–5.75 and 5.90–5.99(bothm, total2H), 6.84(s, 1H), 7.09(d, J=8.4Hz, 1H), 7.33–7.41(m, 4H), 7.68(m, 2H) IR(KBr)1519, 1482, 1390, 1362, 1232, 1180, 1150, 1077, 974, 873, 815, 799, 522cm⁻¹ I-35 m.p. 166–168° C. ¹HNMR(CDCl₃) δ 1.04 and 1.05(botht, bothJ=7.5Hz, total3H), 2.09–2.19(m, 2H), 3.46(s, 3H), 3.74(s, 3H), 4.58 and 4.68(bothm, total2H), 5.01(bs, 1H), 5.69–5.78 and 5.87–5.95(bothm, total4H), 6.45(s, 1H), 6.90–7.06(m, 5H), 7.53(m, 2H) IR(KBr)3531, 3489, 3306, 1523, 1492, 1459, 1408, 1314, 1287, 1270, 1255, 1234, 1224, 1118, 1072, 1018, 1005, 822cm⁻¹ I-36 m.p. 148–150° C. ¹HNMR(CDCl₃) δ 1.62(s, 3H), 1.69(s, 3H), 1.76(s, 3H), 2.08–2.20(m, 4H), 2.71(s, 3H), 3.21(s, 3H), 3.24(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 4.66(d, J=6.3Hz, 2H), 5.09(m, 1H), 5.50(t, J=6.3Hz, 1H), 6.84(s, 1H), 7.10(d, J=8.4Hz, 1H), 7.33–7.41(m, 4H), 7.68(m, 2H) IR(KBr)1519, 1480, 1464, 1449, 1389, 1366, 1291, 1271, 1233, 1200, 1176, 1150, 1118, 1079, 1012, 973, 946, 876, 841, 816, 801, 523, 510cm⁻¹

TABLE 19 I-37 ¹HNMR(CDCl₃) δ 1.58(s, 3H), 1.63(s, 3H), 1.70(s, 3H), 2.05–2.20(m, 4H), 3.46(s, 3H), 3.75(s, 3H), 4.64(d, J=6.3Hz, 2H), 4.95(bs, 1H), 5.11(m, 1H), 5.53(m, 1H), 5.70(s, 1H), 5.90(s, 1H), 6.45(s, 1H), 6.91–7.08(m, 5H), 7.54(m, 2H) I-38 m.p. 149–151° C. ¹HNMR(CDCl₃) δ 1.68(s, 3H), 1.74(s, 3H), 2.55(m, 2H), 2.73(s, 3H), 3.21(s, 3H), 3.22(s, 3H), 3.56(s, 3H), 3.77(s, 3H), 4.07(t, J=6.8Hz, 2H), 5.21(m, 1H), 6.84(s, 1H), 7.08(d, J=8.2Hz, 1H), 7.32–7.40(m, 4H), 7.68(m, 2H) IR(KBr)1520, 1483, 1389, 1363, 1296, 1180, 1151, 1079, 975, 872, 815, 799, 521cm⁻¹ I-39 m.p. 105–107° C. ¹HNMR(CDCl₃) δ 1.68(s, 3H), 1.75(s, 3H), 2.53(m, 2H), 3.54(s, 3H), 3.74(s, 3H), 4.06(t, J=6.8Hz, 2H), 5.01(bs, 1H), 5.22(m, 1H), 5.69(s, 1H), 5.90(s, 1H), 6.45(s, 1H), 6.90–7.06(m, 5H), 7.53(m, 2H) IR(KBr)3477, 3388, 1523, 1489, 1469, 1402, 1285, 1261, 1248, 1227, 1196, 1175, 1164, 1115, 1100, 1073, 1011cm⁻¹ I-40 m.p. 155–157° C. ¹HNMR(CDCl₃) δ 1.89(t, J=2.4Hz, 3H), 3.45(s, 3H), 3.75(s, 3H), 4.74(q, J=2.4Hz, 2H), 5.00(bs, 1H), 5.66(s, 1H), 5.92(s, 1H), 6.45(s, 1H), 6.90–7.08(m, 5H), 7.54(m, 2H) IR(KBr)3446, 2224, 1523, 1488, 1402, 1266, 1238, 1203, 1187, 1166, 1102, 1068, 1009cm⁻¹ I-41 ¹HNMR(CDCl₃) δ 2.19(s, 3H), 3.45(s, 3H), 3.75(s, 3H), 4.62(m, 2H), 4.92(bs, 1H), 5.60(bs, 1H), 5.92(s, 1H), 5.99(m, 1H), 6.45(m, 1H), 6.91–7.08(m, 5H), 7.53(m, 2H) I-42 oil ¹HNMR(CDCl₃) δ 1.76(s, 3H), 1.81(s, 3H), 2.87(s, 3H), 3.22(s, 6H), 3.55(s, 3H), 3.80(s, 3H), 4.66(d, J=7.5Hz, 2H), 5.61(m, 1H), 6.84(s, 1H), 7.37–7.41(m, 3H), 7.61(d, J=2.1Hz, 1H), 7.67(m, 2H)

TABLE 20 I-43 m.p. 132–136° C. ¹HNMR(CDCl₃) δ 1.74(s, 3H), 1.82(s, 3H), 3.44(s, 3H), 3.76(s, 3H), 4.62(m, 2H), 5.05(brs, 1H), 5.61(m, 1H), 5.79(s, 1H), 6.02(s, 1H), 6.44 (s, 1H), 6.92(m, 2H), 7.04(d, J=2.1Hz, 1H), 7.20(d, J=2.1Hz, 1H), 7.53(m, 2H) IR(KBr)3495, 3422, 1611, 1520, 1473, 1400, 1355, 1315, 1280, 1227, 1194, 1173, 1111, 1077, 1023cm⁻¹ I-44 m.p. 148–149° C. ¹HNMR(CDCl₃) δ 1.60(s, 3H), 1.70(s, 3H), 2.32–2.39(m, 2H), 2.65(s, 3H), 2.76–2.81(m, 2H), 3.21(s, 3H), 3.24(s, 3H), 3.56(s, 3H), 3.78 (s, 3H), 5.16–5.21(m, 1H), 6.85(s, 1H), 7.30–7.40(m, 5H), 7.66–7.71(m, 2H) IR(KBr)1480, 1390, 1361, 1181, 1150, 1075cm⁻¹ I-45 m.p. 73–75° C. ¹HNMR(CDCl₃) δ 1.63(s, 3H), 1.72(s, 3H), 2.32–2.39(m, 2H), 2.64–2.70(m, 2H), 3.46(s, 3H), 3.74(s, 3H), 4.83(s, 1H), 4.95(s, 1H), 5.27–5.31 (m, 1H), 5.92(s, 1H), 6.45(s, 1H), 6.89–7.00(m, 4H), 7.21(d, J=10.5Hz, 1H), 7.52–7.55(m, 2H) IR(KBr)3600–3200(br), 3100–2800(br), 1612, 1579, 1523, 1487, 1452, 1400, 1360, 1226, 1174, 1111, 1072cm⁻¹ I-46 ¹HNMR(CDCl₃) δ 3.45(s, 3H), 3.75(s, 3H), 4.65(m, 2H), 4.85(s, 1H), 5.33(m, 1H), 5.44(m, 1H), 5.67(s, 1H), 5.91(s, 1H), 6.10(m, 1H), 6.45 (s, 1H), 6.92(m, 2H), 6.95(m, 2H), 7.08(m, 1H), 7.54(m, 2H) I-47 ¹HNMR(acetone-d₆) δ 3.39(s, 3H), 3.72(s, 3H), 5.20(s, 2H), 6.48(s, 1H), 6.83(dd, J=2.0Hz, J=8.4Hz, 1H), 6.93(m, 2H), 6.96(d, J=2.0Hz, 1H), 7.04(d, J=8.4Hz, 1H), 7.34–7.45(m, 3H), 7.52(m, 2H), 7.52–7.58(m, 2H) IR(CHCl₃)3522, 3348, 1699, 1612, 1589, 1521, 1489, 1458, 1402, 1288, 1114, 1071, 935cm⁻¹ I-48 ¹HNMR(acetone-d₆) δ 1.28(t, J=7.2Hz, 3H), 3.39(s, 3H), 3.72(s, 3H), 4.25(q, J=7.2Hz, 2H), 4.78(s, 2H), 6.49(s, 1H), 6.83(dd, J=1.8 and 8.4Hz, 1H), 6.93(m, 2H), 6.96(d, J=1.8Hz, 1H), 6.97(d, J=8.4Hz, 1H), 7.52(m, 2H), 7.63(s, 1H), 7.83(s, 1H), 8.50(s, 1H) I-49 ¹HNMR(acetone-d₆) δ 1.75(m, 3H), 3.39(s, 3H), 3.72(s, 3H), 4.56(m, 2H), 5.71–5.82(m, 1H), 5.84–5.96(m, 1H), 6.48(s, 1H), 6.82(dd, J=2.0 and 8.4Hz, 1H), 6.93(d, J=2.0Hz, 1H), 6.93(m, 2H), 6.95(d, J=8.4Hz, 1H), 7.52(m, 2H)

TABLE 21 I-50 ¹HNMR(acetone-d₆) δ 1.75(m, 3H), 3.39(s, 3H), 3.72(s, 3H), 4.72(m, 2H), 5.73–5.75(m, 2H), 6.48(s, 1H), 6.83(dd, J=2.0 and 7.8Hz, 1H), 6.92–6.95(m, 3H), 6.97(d, J=7.8Hz, 1H), 7.52(m, 2H) I-51 ¹HNMR(acetone-d₆) δ 1.77(s, 3H), 1.79(s, 3H), 3.41(s, 3H), 3.72(s, 3H), 4.66(m, 2H), 5.53(m, 1H), 6.49(s, 1H), 6.85(m, 2H), 7.04(d, J=8.1Hz, 1H), 7.10(dd, J=2.1 and 8.1Hz, 1H), 7.19(d, J=2.1Hz, 1H), 7.25(m, 2H) I-52 ¹HNMR(CDCl₃) δ 2.58(t, J=2.2Hz, 1H), 2.73(s, 3H), 3.22(s, 3H), 3.26(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 4.83(d, J=2.2Hz, 2H), 6.85(s, 1H), 7.21(d, J=8.4Hz, 1H), 7.35–7.46(m, 4H), 7.64–7.74(m, 2H) I-53 ¹HNMR(CDCl₃) δ 3.45(s, 3H), 3.76(s, 3H), 4.36(d, J=1.5Hz, 1H), 4.55(s, 2H), 4.76(dd, J=1.8 and 0.6Hz, 1H), 5.02(brs, 1H), 5.97(d, J=0.9Hz, 1H), 6.45(s, 1H), 6.90–6.96(m, 2H), 6.96–7.05(m, 2H), 7.10–7.12(m, 1H), 7.50–7.58(m, 2H I-54 ¹HNMR(CDCl₃) δ 1.76(s, 3H), 1.82(s, 3H), 2.61(s, 3H), 3.53(s, 3H), 3.77(s, 3H), 4.61(d, J=6.9Hz, 2H), 5.17(brs, 1H), 5.45–5.50(m, 1H), 5.72(s, 1H), 6.84(s, 1H), 6.88–7.00(m, 4H), 7.02(d, J=1.8Hz, 1H), 7.50–7.57(m, 2H) I-55 ¹HNMR(CDCl₃) δ 0.99(d, J=6.5Hz, 6H), 1.74(q, J=6.5Hz, 2H), 1.85(m, 1H), 3.46(s, 3H), 3.75(s, 3H), 4.12(t, J=6.5Hz, 2H), 4.97(s, 1H), 5.65(s, 1H), 5.90(s, 1H), 6.45(s, 1H), 6.92(m, 2H), 6.95(m, 2H), 7.06(m, 1H), 7.54(m, 2H) I-56 ¹HNMR(CDCl₃) δ 1.34(s, 3H), 1.35(s, 3H), 3.15(dd, J=3.6 and 6.6Hz, 1H), 3.39(s, 3H), 3.72(s, 3H), 4.10(dd, J=6.6 and 11.1Hz and, 1H), 4.34 (dd, J=3.6 and 11.1Hz, 1H), 6.49(s, 1H), 6.83(dd, J=1.8 and 8.1Hz, 1H), 6.93(d, J=8.7Hz, 2H), 6.94(d, J=1.8Hz, 1H), 7.00(d, J=8.1Hz, 1H), 7.52(d, J=8.7Hz, 2H) I-57 ¹HNMR(CDCl₃) δ 2.68(s, 3H), 3.13(s, 3H), 3.53(s, 3H), 3.78(s, 3H), 5.19(s, 2H), 6.83(s, 1H), 7.10–7.19(m, 3H), 7.31–7.50(m, 7H), 7.57–7.64 (m, 2H) IR(KBr)1607, 1520, 1481, 1373, 1231, 1176, 1119, 1078cm⁻¹ I-58 ¹HNMR(CDCl₃) δ 1.76(s, 3H), 1.82(s, 3H), 2.72(s, 3H), 3.23(s, 3H), 3.53(s, 3H), 3.78(s, 3H), 3.78(s, 3H), 4.64(d, J=6.6Hz, 2H), 6.84(t, J=6.6Hz, 1H), 5.83(s, 1H), 7.06–7.20(m, 3H), 7.31–7.40(m, 2H), 7.56–7.65(m, 2H) IR(KBr)1603, 1521, 1483, 1376, 1366, 1176, 1085cm⁻¹

TABLE 22 I-59 ¹HNMR(CDCl₃) δ 1.76(s, 3H), 1.82(s, 3H), 3.45(s, 3H), 3.75(s, 3H), 4.62(d, J=6.9Hz, 2H), 5.52(t, J=6.9Hz, 1H), 5.71(brs, 1H), 5.89(s, 1H), 6.44(s, 1H), 6.90–7.19(m, 5H), 7.56–7.67(m, 2H) IR(KBr)3545, 3385, 1605, 1586, 1561, 1520, 1384, 1311, 1284, 1225, 1121, 1096cm⁻¹ I-60 ¹HNMR(CDCl₃) δ 3.49(s, 3H), 3.74(s, 3H), 5.15(s, 2H), 5.68(s, 1H), 5.91(s, 1H), 6.02(s, 2H), 6.43(s, 1H), 6.88–7.19(m, 6H), 7.31–7.48 (m, 5H) IR(CHCl₃)3535, 1615, 1588, 1519, 1500, 1482, 1410, 1290, 1241, 1204, 1092, 1041cm⁻¹ I-61 ¹HNMR(CDCl₃) δ 1.76(s, 3H), 1.81(s, 3H), 2.73(s, 3H), 3.23(s, 3H), 3.57(s, 3H), 3.77(s, 3H), 4.64(d, J=6.6Hz, 1H), 5.50(t, J=6.6Hz, 1H), 6.03 (s, 2H), 6.83(s, 1H), 6.91(d, J=8.1Hz, 1H), 7.08(d, J=8.1Hz, 1H), 7.09(d, J=8.1Hz, 1H), 7.14(s, 1H), 7.34(d, J=8.1Hz, 1H), 7.39(s, 1H) IR(CHCl₃)1607, 1518, 1477, 1453, 1369, 1240, 1178, 1081cm⁻¹ I-62 ¹HNMR(CDCl₃) δ 1.76(s, 3H), 1.82(s, 3H), 3.49(s, 3H), 3.74(s, 3H), 4.61(d, J=6.9Hz, 2H), 5.53(t, J=6.9Hz, 1H), 5.68(s, 1H), 6.02(s, 2H), 6.43(s, 1H), 6.88–6.96(m, 3H), 7.03–7.18(m, 3H) IR(KBr)3494, 1610, 1583, 1561, 1519, 1480, 1460, 1409, 1286, 1243, 1191, 1127, 1089, 1036cm⁻¹ I-63 m.p. 201–202° C. ¹HNMR(CDCl₃) δ 3.78(s, 6H), 5.16(s, 4H), 5.69(s, 2H), 6.93(s, 2H), 6.99(d, J=8.4Hz, 2H), 7.08(dd, J=2.1 and 8.4Hz, 2H), 7.22(d, J=2.1Hz, 2H), 7.37–7.47(m, 10H), IR(KBr)3600–3100(br), 1584, 1523, 1454, 1272, 1245, 1210, 1130cm⁻¹ I-64 m.p. 173–175° C. ¹HNMR(CDCl₃) δ 3.12(s, 6H), 3.80(s, 6H), 5.18(s, 4H), 6.92(s, 2H), 7.12(d, J=8.7Hz, 2H), 7.36–7.50(m, 12H), 7.60(d, J=2.1Hz, 2H) IR(KBr)1523, 1492, 1356, 1290, 1263, 1210, 1182, 1114cm⁻¹

TABLE 23 I-65 ¹HNMR(CDCl₃) δ 1.76(d, J=0.9Hz, 6H), 1.81(d, J=0.6Hz, 6H), 3.22(s, 6H), 3.80(s, 6H), 4.63(d, J=6.6Hz, 4H), 5.48–5.53(m, 2H), 6.92 (s, 2H), 7.05(d, J=8.4Hz, 2H), 7.48(dd, J=2.1 and 8.4Hz, 2H), 7.57(d, J=2.1Hz, 2H) IR(KBr)1523, 1492, 1468, 1353, 1286, 1258, 1213, 1174, 1108cm⁻¹ I-66 ¹HNMR(CDCl₃) δ 1.76(s, 6H), 1.82(s, 6H), 3.78(s, 6H), 4.62(d, J=6.9Hz, 4H), 5.50–5.55(m, 2H), 5.71(s, 2H), 6.91–6.94(m, 4H), 7.08(dd, J=2.1 and 8.4Hz, 2H), 7.57(d, J=2.1Hz, 2H) IR(KBr)3600–3200(br), 1523, 1492, 1271, 1242, 1210, 1186, 1034cm⁻¹ I-67 ¹HNMR(CDCl₃) δ 1.77(s, 3H), 1.81(s, 3H), 3.22(s, 3H), 3.28(s, 3H), 3.79(s, 3H), 3.80(s, 3H), 4.63(d, J=6.6Hz, 2H), 5.48–5.53(m, 1H), 6.92 (s, 1H), 6.93(s, 1H), 7.06(d, J=8.4Hz, 1H), 7.13(d, J=8.4Hz, 2H), 7.42–7.51(m, 3H), 7.57(d, J=21Hz, 1H) IR(KBr)3600–3200(br), 1525, 1493, 1362, 1293, 1210, 1172, 1107cm⁻¹ I-68 m.p. 168–169° C. ¹HNMR(CDCl₃) δ 3.18(s, 3H), 3.78(s, 3H), 3.79(s, 3H), 5.17(s, 2H), 5.71(s, 1H), 6.92(s, 1H), 6.96(s, 1H), 6.99(d, J=8.7Hz, 1H), 7.08(dd, J=2.1 and 8.7Hz, 1H), 7.24(d, J=2.1Hz, 1H), 7.26–7.48(m, 7H) IR(KBr)3600–3200(br), 1488, 1382, 1369, 1269, 1206, 1174, 1146cm⁻¹ I-69 m.p. 155–157° C. ¹HNMR(CDCl₃) δ 3.12(s, 3H), 3.19(s, 3H), 3.80(s, 6H), 5.18(s, 2H), 6.92(s, 1H), 6.95(s, 1H), 7.12(d, J=8.7Hz, 1H), 7.32–7.51(m, 8H), 7.60–7.65(m, 3H) IR(KBr)1491, 1363, 1210, 1174, 1151, 1114cm⁻¹ I-70 m.p. 109–110° C. ¹HNMR(CDCl₃) δ 1.77(s, 3H), 1.81(s, 3H), 3.19(s, 3H), 3.23(s, 3H), 3.80(s, 6H), 4.64(d, J=6.6Hz, 2H), 5.05–5.30(m, 1H), 6.92(s, 1H), 6.95 (s, 1H), 7.06(d, J=8.7Hz, 1H), 7.33–7.37(m, 2H), 7.49(dd, J=2.1 and 8.7Hz, 1H)7.58(d, J=2.1Hz, 1H), 7.61–7.64(m, 2H) IR(KBr)1522, 1489, 1368, 1351, 1294, 1260, 1212, 1178, 1149, 1114, 975cm⁻¹

TABLE 24 I-71 ¹HNMR(CDCl₃) δ 1.72(s, 3H), 1.76(s, 3H), 3.72(s, 3H), 3.73(s, 3H), 4.56(d, J=6.6Hz, 2H), 5.46–5.49(brs, 1H), 6.79–6.82(m, 2H), 6.88–7.01 (m, 5H), 7.34–7.39(m, 2H), 8.89(s, 1H), 9.45(s, 1H) IR(KBr)3600–3100(br), 1524, 1493, 1458, 1386, 1261, 1206, 1010cm⁻¹ I-72 m.p. 123–124° C. ¹HNMR(CDCl₃) δ 1.77(s, 3H), 1.81(s, 3H), 3.19(s, 3H), 3.80(s, 6H), 4.64(d, J=6.9Hz, 2H), 5.52–5.57(m, 1H), 6.93(s, 1H), 6.94(s, 1H), 7.04 (t, J=8.7Hz, 1H), 7.26–7.39(m, 3H), 7.60–7.65(m, 2H) IR(KBr)1524, 1494, 1463, 1379, 1265, 1211, 1174, 1154, 1130cm⁻¹ I-73 m.p. 118–119° C. ¹HNMR(CDCl₃) δ 1.77(s, 3H), 1.81(s, 3H), 3.79(s, 3H), 3.80(s, 3H), 4.63(d, J=6.9Hz, 2H), 4.86(s, 1H), 5.52–5.57(m, 1H), 6.88–6.93(m, 4H), 7.03(t, J=8.7Hz, 1H), 7.26–7.29(m, 1H), 7.37(dd, J=2.4 and 12.9Hz, 1H), 7.40–7.50(m, 2H) IR(KBr)3600–3100(br), 1525, 1492, 1466, 1381, 1263, 1206cm⁻¹ I-74 ¹HNMR(CDCl₃) δ 2.63(s, 3H), 3.19(s, 3H), 5.18(s, 2H), 5.74(s, 1H), 7.03(d, J=8.4Hz, 1H), 7.07(dd, J=2.1 and 8.4Hz, 1H), 7.12(d, J=2.1Hz, 1H), 7.36–7.68(m, 12H) IR(KBr)3700–3200(br), 1486, 1367, 1353, 1197, 1179, 1147cm⁻¹ I-75 ¹HNMR(CDCl₃) δ 2.80(s, 3H), 3.14(s, 3H), 3.19(s, 3H), 5.20(s, 2H), 7.18(d, J=8.4Hz, 1H), 7.38–7.68(m, 14H) IR(KBr)1485, 1361, 1186, 1156, 1107cm⁻¹ I-76 ¹HNMR(CDCl₃) δ 1.78(s, 3H), 1.82(s, 3H), 2.81(s, 3H), 3.19(s, 3H), 3.26(s, 3H), 4.65(d, J=7.2Hz, 1H), 5.47–5.52(m, 1H), 7.11(d, J=8.7Hz, 1H), 7.37–7.67(m, 9H) IR(KBr)1486, 1365, 1186, 1154, 1106, 973, 926, 870, 810cm⁻¹

TABLE 25 I-77 m.p. 174–176° C. ¹HNMR(CDCl₃), δ 1.72(s, 3H), 1.76(s, 3H), 4.55(d, J=6.0Hz, 2H), 5.45–5.49(m, 1H), 6.82–7.43(m, 10H), 8.84(s, 1H), 9.45(s, 1H), 9.53(s, 1H) IR(KBr)3600–3100(br), 1610, 1594, 1532, 1496, 1444, 1409, 1305, 1245, 1209cm⁻¹ I-78 m.p. 134–135° C. ¹HNMR(CDCl₃) δ 3.78(s, 3H), 3.79(s, 3H), 5.17(s, 2H), 5.70(s, 1H), 6.91(s, 1H), 6.95(s, 1H), 6.99(d, J=8.4Hz, 1H), 7.07–7.14(m, 3H), 7.22 (d, J=2.1Hz, 1H), 7.36–7.47(m, 5H), 7.52–7.57(m, 2H) IR(KBr)3600–3100(br), 1524, 1494, 1462, 1381, 1273, 1248, 1213cm⁻¹ I-79 ¹HNMR(CDCl₃) δ 3.12(s, 3H), 3.79(s, 3H), 3.80(s, 3H), 5.18(s, 2H), 6.92(s, 1H), 6.94(s, 1H), 7.09–7.15(m, 3H), 7.38–7.56(m, 8H), 7.60 (d, J=2.1Hz, 1H) IR(KBr)1522, 1493, 1467, 1387, 1365, 1279, 1213, 1112cm⁻¹ I-80 m.p. 110–111° C. ¹HNMR(CDCl₃) δ 1.77(s, 3H), 1.81(s, 3H), 3.22(s, 3H), 3.78(s, 3H), 3.80(s, 3H), 4.63(d, J=6.9Hz, 2H), 5.50–5.57(m, 1H), 6.91(s, 1H), 6.94 (s, 1H), 7.04–7.14(m, 3H), 7.47–7.58(m, 4H) IR(KBr)1552, 1493, 1364, 1212, 1110, 970cm⁻¹ I-81 ¹HNMR(CDCl₃) δ 1.77(s, 3H), 1.82(s, 3H), 3.78(s, 3H), 3.79(s, 3H), 4.62(d, J=6.9Hz, 2H), 5.50–5.55(m, 1H), 5.72(s, 1H), 6.91–6.95(m, 3H), 7.06–7.14(m, 3H), 7.20(d, J=1.8Hz, 1H), 7.52–7.57(m, 2H) IR(KBr)3536, 1520, 1493, 1386, 1271, 1241, 1210cm⁻¹ I-82 ¹HNMR(CDCl₃) δ 1.29(t, J=7.2Hz, 3H), 1.76(s, 3H), 1.79(s, 3H), 3.78(s, 6H), 3.78(q, 2H), 4.64(d, J=6.3Hz, 2H), 4.72(s, 2H), 5.53–5.78 (m, 1H), 6.61(s, 1H), 6.94(s, 1H), 6.98(d, J=8.7Hz, 1H), 7.09–7.20(m, 4H), 7.52–7.57(m, 2H) IR(KBr)1758, 1524, 1496, 1461, 1387, 1263, 1209, 1147cm⁻¹

TABLE 26 I-83 ¹HNMR(CDCl₃) δ 2.76(s, 3H), 3.21(s, 3H), 3.55(s, 3H), 3.77(s, 3H), 5.26(s, 2H), 6.85(s, 1H), 7.17(d, J=8.7Hz, 1H), 7.31–7.50(m, 8H), 7.60–7.71(m, 3H), 7.92(s, 1H) IR(KBr)1684, 1606, 1512, 1478, 1177, 1150, 1080, 1016cm⁻¹ I-84 ¹HNMR(CDCl₃) δ 1.26(t, J=7.2Hz, 3H), 3.08(s, 3H), 3.22(s, 3H), 3.31(s, 3H), 3.74(s, 3H), 4.16(q, J=7.2Hz, 2H), 5.17(s, 2H), 6.44(d, J=16.5Hz, 1H), 6.89(s, 1H), 7.13(s, 2H), 7.27(d, J=8.4Hz, 1H), 7.35–7.50(m, 8H), 7.69(d, J=8.4Hz, 2H) IR(KBr)1708, 1633, 1513, 1465, 1367, 1271, 1230, 1176, 1151, 1120, 1017cm⁻¹ I-85 ¹HNMR(CDCl₃) δ 1.26(t, J=7.2Hz, 3H), 3.22(s, 3H), 3.31(s, 3H), 3.74(s, 3H), 4.16(q, J=7.2Hz, 2H), 5.15(s, 2H), 5.70(s, 1H), 6.53(d, J=16.5Hz, 1H), 6.69(dd, J=8.4and2.4Hz, 1H), 6.88(s, 2H), 7.00(d, J=8.4Hz, 1H), 7.33–7.50(m, 8H), 7.70(d, J=8.4Hz, 2H) IR(KBr)3398, 1675, 1627, 1581, 1512, 1465, 1370, 1284, 1256, 1221, 1148, 1074, 1017cm⁻¹ I-86 ¹HNMR(CDCl₃) δ 2.53(s, 3H), 3.21(s, 3H), 3.56(s, 3H), 3.77(s, 3H), 4.58(s, 2H), 5.24(s, 2H), 6.83(s, 1H), 6.96(d, J=8.4Hz, 1H), 7.28–7.57 (m, 9H), 7.69(d, J=8.4Hz, 2H) IR(KBr)1605, 1512, 1479, 1366, 1233, 1175, 1149, 1080, 1015cm⁻¹ I-87 ¹HNMR(CDCl₃) δ 1.76(s, 3H), 1.81(s, 3H), 3.27(s, 3H), 3.78(s, 3H), 3.79(s, 3H), 4.63(d, J=6.6Hz, 2H), 5.40–5.50(m, 1H), 5.71(s, 1H), 6.07 (s, 1H), 6.91–6.95(m, 3H), 7.05–7.20(m, 3H), 7.43–7.51(m, 2H) IR(KBr)3600–3200(br), 1617, 1525, 1494, 1464, 1361, 1292, 1208, 1178, 1101, 1033cm⁻¹ I-88 ¹HNMR(CDCl₃) δ 2.57(s, 3H), 3.20(s, 3H), 3.56(s, 3H), 3.79(s, 3H), 5.18(s, 2H), 6.84(s, 1H), 7.06–7.15(m, 1H), 7.20–7.40(m, 9H), 7.47–7.57 (m, 2H), 7.60–7.75(m, 3H), 8.20–8.25(m, 2H) I-89 ¹HNMR(CDCl₃) δ 3.44(s, 3H), 3.75(s, 3H), 5.01(s, 1H), 5.18(s, 2H), 6.01(s, 1H), 6.45(s, 1H), 6.88–6.97(m, 2H), 7.07(dd, J=8.4and8.4Hz, 1H), 7.15–7.21(m, 1H), 7.27(dd, J=12.3 and 2.1Hz, 1H), 7.29–7.43(m, 3H), 7.45–7.56(m, 4H)

TABLE 27 I-90 ¹HNMR(CDCl₃) δ 1.68(s, 3H), 1.75(d, J=0.9Hz, 3H), 2.55(dt, J=6.9and6.9Hz, 2H), 2.70(s, 3H), 3.21(s, 3H), 3.55(s, 3H), 3.77(s, 3H), 4.04 (t, J=6.9Hz, 2H), 5.17–5.28(m, 1H), 6.84(s, 1H), 7.04(dd, J=8.4and8.4Hz, 1H), 7.11–7.22(m, 2H), 7.34–7.42(m, 2H), 7.65–7.75(m, 2H) IR(KBr)1522, 1483, 1361, 1352, 1176, 1156, 1079, 963, 873, 801cm⁻¹ I-91 ¹HNMR(CDCl₃) δ 2.96(s, 3H), 3.52(s, 3H), 3.58(s, 6H), 3.73(s, 3H), 4.89(s, 2H), 5.19(s, 2H), 5.23(s, 2H), 5.25(s, 2H), 6.68(s, 1H), 6.98 (d, J=8.4Hz, 1H), 7.04(dd, J=8.4and2.1Hz, 1H), 7.11(m, 2H), 7.25(d, J=2.1Hz, 1H), 7.30–7.40(m, 5H), 7.51(m, 2H) IR(KBr)2952, 2935, 2896, 1609, 1521, 1477, 1463, 1438, 1383, 1269, 1249, 1228, 1183, 1153, 1130, 1116, 1078, 1066, 1020, 1008, 984, 944, 922, 903, 832, 801, 730cm⁻¹ I-92 mp 122–124° C. ¹HNMR(CDCl₃) δ 2.70(brs, 3H), 3.55–3.60(br, 2H), 3.60(s, 3H), 3.75(s, 3H), 3.81–3.83(m, 2H), 3.87(s, 3H), 5.15(s, 2H), 5.68(s, 1H), 6.69 (s, 1H), 6.94(dd, J=2.1, 8.4Hz, 1H), 6.97–7.03(m, 3H), 7.07(d, J=1.8Hz, 1H), 7.38–7.48(m, 5H), 7.51–7.56(m, 2H) IR(KBr)3600–2800(br), 1607, 1597, 1550, 1518, 1477, 1462, 1452, 1392, 1289, 1248, 1228, 1175, 1122, 1096, 1084, 1015cm⁻¹ I-93 ¹HNMR(CDCl₃) δ 2.59(dt, J=6.6, 6.6Hz, 2H), 3.45(s, 3H), 3.74(s, 3H), 4.15(t, J=6.6Hz, 2H), 5.15(dm, J=10.2Hz, 1H), 5.21(dm, J=17.1Hz, 1H), 5.90(m, 1H), 6.45(s, 1H), 6.92(d, J=8.4Hz, 2H), 6.95(s, 2H), 7.06(brs, 1H), 7.53(d, J=8.4Hz, 2H) IR(Nujol)3570, 3525, 3336, 3205, 1616, 1596, 1524, 1493, 1409, 1315, 1286, 1264, 1239, 1225, 1117, 1072, 821, 783cm⁻¹ I-94 ¹HNMR(CDCl₃) δ 0.36(m, 2H), 0.66(m, 2H), 1.31(m, 1H), 3.45(s, 3H), 3.74(s, 3H), 3.91(d, J=7.2Hz, 2H), 6.44(s, 1H), 6.91(d, J=8.7Hz, 2H), 6.93(m, 2H), 7.07(d, J=1.8Hz, 1H), 7.53(d, J=8.7Hz, 2H) IR(Nujol)3570, 3491, 3364, 3178, 1617, 1598, 1583, 1524, 1494, 1408, 1313, 1285, 1266, 1240, 1224, 1115, 1072, 1011, 822, 786cm⁻¹ I-95 ¹HNMR(CDCl₃) δ 1.86(s, 3H), 3.45(s, 3H), 3.74(s, 3H), 4.54(s, 2H), 5.04(brs, 1H), 5.12(brs, 1H), 6.45(s, 1H), 6.91(d, J=8.7Hz, 2H), 6.95 (m, 2H), 7.08(brs, 1H), 7.53(d, J=8.7Hz, 2H) IR(Nujol)3536, 3364, 3179, 1614, 1586, 1524, 1493, 1407, 1309, 1284, 1265, 1238, 1226, 1115, 1073, 1011, 887, 821, 782cm⁻¹

TABLE 28 I-96 ¹HNMR(CDCl₃) δ 2.58(t, J=2.4Hz, 1H), 3.45(s, 3H), 3.74(s, 3H), 4.79(d, J=2.4Hz, 2H), 6.45(s, 1H), 6.92(d, J=8.7Hz, 2H), 6.98(dd, J=8.4, 2.1Hz, 1H), 7.07(d, J=8.4Hz, 1H), 7.09(d, J=2.1Hz, 1H), 7.53(d, J=8.7Hz, 2H) IR(Nujol)3410, 3282, 1612, 1589, 1523, 1489, 1404, 1226, 1114, 1071, 1015, 826cm⁻¹ I-97 ¹HNMR(CDCl₃) δ 2.71(s, 3H), 3.21(s, 3H), 3.38(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 5.47(s, 2H), 6.84(s, 1H), 7.00(d, J=8.6Hz, 1H), 7.34(dd, J=8.6, 2.0Hz, 1H), 7.38(d, J=8.8Hz, 2H), 7.46(d, J=2.0Hz, 1H), 7.55(m, 2H), 7.67(m, 1H), 7.68(d, J=8.8Hz, 2H), 7.99(m, 2H) I-98 m.p. 200–203° C. ¹HNMR(CDCl₃) δ 2.38(s, 3H), 2.67(s, 3H), 3.12(s, 3H), 3.21(s, 3H), 3.56(s, 3H), 3.77(s, 3H), 5.14(s, 2H), 6.84(s, 1H), 7.15(d, J=8.7Hz, 1H), 7.21(d, J=8.1Hz, 2H), 7.34(d, J=8.1Hz, 2H), 7.34(dd, J=8.7, 2.4Hz, 1H), 7.38(d, J=8.7Hz, 2H), 7.40(d, J=2.4Hz, 1H), 7.68(d, J=8.7Hz, 2H) IR(Nujol)1608, 1520, 1480, 1359, 1173, 1156, 1078, 1016, 976, 948, 872, 818, 791cm⁻¹ I-99 ¹HNMR(CDCl₃) δ 2.72(s, 3H), 3.13(s, 3H), 3.21(s, 3H), 3.55(s, 3H), 3.78(s, 3H), 5.15(s, 2H), 6.84(s, 1H), 7.09(d, J=8.7Hz, 1H), 7.12(dd, J=8.7, 7.2Hz, 1H), 7.35(dd, J=8.7, 2.1Hz, 1H), 7.38(d, J=8.7Hz, 2H), 7.40(d, J=2.1Hz, 1H), 7.45(dd, J=8.7, 5.1Hz, 1H), 7.68(d, J=8.7Hz, 2H) I-100 ¹HNMR(CDCl₃) δ 2.76(s, 3H), 3.19(s, 3H), 3.21(s, 3H), 3.55(s, 3H), 3.78(s, 3H), 5.25(s, 2H), 6.85(s, 1H), 7.13(d, J=8.4Hz, 1H), 7.32(dd, J=8.4, 1.8Hz, 1H), 7.36(dd, J=8.4, 1.8Hz, 1H), 7.38(d, J=8.7Hz, 2H), 7.42(d, J=1.8Hz, 1H), 7.45(d, J=1.8Hz, 1H), 7.59(d, J=8.4Hz, 1H), 7.68(d, J=8.7Hz, 2H) I-101 m.p. 103–105° C. ¹HNMR(CDCl₃) δ 2.18(dd, J=1.5, 1.2Hz, 3H), 3.45(s, 3H), 3.74(s, 3H), 4.79(dd, J=5.7, 1.2Hz, 2H), 5.81(dt, J=5.7, 1.5Hz, 2H), 6.45(s, 1H), 6.92(d, J=8.7Hz, 2H), 6.95(s, 1H), 6.96(s, 1H), 7.07(s, 1H), 7.52(d, J=8.7Hz, 2H) IR(KBr)3527, 3328, 2930, 1614, 1593, 1523, 1492, 1463, 1408, 1262, 1235, 1225, 1119, 1072, 1010, 828, 805cm⁻¹

TABLE 29 I-102 m.p. 95–99° C. ¹HNMR(CDCl₃) δ 3.45(s, 3H), 3.74(s, 3H), 4.67(s, 2H), 5.47(m, 1H), 5.55(dd, J=2.7, 1.2Hz, 1H), 6.45(s, 1H), 6.92(d, J=8.7Hz, 2H), 7.01 (m, 2H), 7.04(d, J=1.8Hz, 1H), 7.53(d, J=8.7Hz, 2H) I-103 ¹HNMR(CDCl₃) δ 3.45(s, 3H), 3.75(s, 3H), 4.59(d, J=4.2Hz, 2H), 6.45(s, 1H), 6.45(m, 1H), 6.55(d, J=12.9Hz, 1H), 6.92(d, J=8.7Hz, 2H), 6.96(brs, 2H), 7.08(brs, 1H), 7.53(d, J=8.7Hz, 2H) I-104 ¹HNMR(CDCl₃) δ 3.45(s, 3H), 3.75(s, 3H), 4.64(dd, J=6.0and1.2Hz, 2H), 6.23(dt, J=13.2and6.0Hz, 1H), 6.42(dt, J=13.2and1.2Hz, 1H), 6.45(s, 1H), 6.91(d, J=8.7Hz, 2H), 6.96(brs, 2H), 7.08(brs, 1H), 7.58(d, J=8.7Hz, 2H) I-105 ¹HNMR(CDCl₃) δ 3.46(s, 3H), 3.75(s, 3H), 3.98(d-like, J=7.2Hz, 1H), 4.64(d-like, J=3.9Hz, 1H), 6.04(dt, J=15.3, 4.8Hz, 1H), 6.06(1H, dt, J=15.3, 6.0Hz, 1H), 6.45(s, 1H), 6.92(d, J=8.7Hz, 2H), 6.95(s, 1H), 7.08(s, 2H), 7.53(d, J=8.7Hz, 2H) I-106 foam ¹HNMR(CDCl₃) δ 1.76(s, 3H), 1.83(s, 3H), 2.08(s, 3H), 3.36(s, 3H), 3.71(s, 3H), 4.61(d, J=7.0Hz, 2H,), 4.94(s, 1H), 5.54(t, J=7.0Hz, 1H), 5.70(s, 1H), 6.70(dd, J=8.4, 2.0Hz, 1H), 6.74(s, 1H), 6.84(d, J=2.0Hz, 1H) IR(KBr)3410, 1520, 1476, 1390, 1243, 1225, 1101, 1084, 834, 812, 775cm⁻¹ I-107 m.p. 112–114° C. ¹HNMR(CDCl₃) δ 3.03(s, 3H), 3.57(s, 3H), 3.74(s, 3H), 3.87(s, 3H), 4.90(S, 2H), 5.15(s, 2H), 5.63(brs, 1H), 6.68(s, 1H), 6.91–7.07(m, 5H), 7.38–7.51(m, 5H), 7.53(m, 2H) IR(KBr)3512, 2952, 2936, 1607, 1519, 1468, 1442, 1382, 1284, 1253, 1229, 1215, 1185, 1156, 1112, 1079, 1065, 1020, 983, 956, 914, 831cm⁻¹ I-108 ¹HNMR(CDCl₃) δ 2.20(d, J=1.2Hz, 3H), 2.76(s, 3H), 3.22(s, 3H), 3.24(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 4.65(m, 2H), 5.96(m, 1H), 7.07 (d, J=8.4Hz, 1H), 7.34–7.41(m, 4H), 7.68(m, 2H)

TABLE 30 I-109 m.p. 153–154° C. ¹HNMR(CDCl₃) δ 2.20(d, J=1.5Hz, 3H), 2.75(s, 3H), 3.21(s, 3H), 3.23(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 4.81(m, 2H), 5.80(m, 1H), 6.84( s, 1H), 7.10(d, J=8.1Hz, 1H), 7.34–7.41(m, 4H), 7.68(m, 2H) IR(KBr)1519, 1481, 1390, 1364, 1234, 1177, 1150, 1119, 1077, 1011, 969, 945, 876, 816, 799, 521cm⁻¹ I-110 ¹HNMR(CDCl₃) δ 2.68(s, 3H), 3.11(s, 3H), 3.21(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 3.83(s, 3H), 5.11(s, 2H), 6.84(s, 1H), 6.93(d, J=8.7Hz, 2H), 7.16(d, J=8.7Hz, 1H), 7.35(dd, J=8.7, 2.1Hz, 1H), 7.36–7.40(m, 5H), 7.68(d, J=8.7Hz, 2H) I-111 ¹HNMR(CDCl₃) δ 2.78(s, 3H), 3.22(s, 6H), 3.55(s, 3H), 3.78(s, 3H), 5.23(s, 2H), 6.85(s, 1H), 7.08(d, J=8.7Hz, 1H), 7.34(dd, J=8.7, 2.1Hz, 1H), 7.39(d, J=8.7Hz, 2H), 7.42(d, J=2.1Hz, 1H), 7.44(brs, 2H), 7.68(d, J=8.7Hz, 2H), 8.70(brs, 2H) I-112 ¹HNMR(CDCl₃) δ 2.70(s, 3H), 3.21(s, 3H), 3.24(s, 3H), 3.55(s, 3H), 3.78(s, 3H), 5.33(s, 2H), 6.84(s, 1H), 7.15(d, J=8.4Hz, 1H), 7.27(dd, J=7.5, 4.2Hz, 1H), 7.33(dd, J=8.4, 2.4Hz, 1H), 7.38(d, J=8.7Hz, 2H), 7.42(d, J=2.4Hz, 1H), 7.62(brd, J=7.5Hz, 1H), 7.68(d, J=8.7Hz, 2H), 7.76(ddd, J=7.5, 7.5, 1.8Hz, 1H), 8.61(d, J=4.2Hz, 1H) I-113 ¹HNMR(CDCl₃) δ 2.76(s, 3H), 3.15(s, 3H), 3.21(s, 3H), 3.55(s, 3H), 3.78(s, 3H), 5.22(s, 2H), 6.85(s, 1H), 7.17(d, J=8.4Hz, 1H), 7.38(dd, J=8.4, 2.1Hz, 1H), 7.38(m, 1H), 7.39(d, J=8.7Hz, 2H), 7.42(d, J=2.1Hz, 1H), 7.68(d, J=8.7Hz, 2H), 7.88(d, J=7.8Hz, 1H), 7.64(brs, 1H), 8.73(brs, 1H) I-114 ¹HNMR(CDCl₃) δ 3.45(s, 3H), 3.74(s, 3H), 5.10(s, 2H), 6.45(s, 1H), 6.91(d, J=8.7Hz, 2H), 6.95(dd, J=8.4, 2.1Hz, 1H), 7.03(d, J=8.4Hz, 1H), 7.08(d, J=2.1Hz, 1H), 7.23(brd, J=7.8Hz, 2H), 7.34(brd, J=7.8Hz, 2H), 7.53(d, J=8.7Hz, 2H) IR(Nujol)3464, 3344, 1611, 1581, 1523, 1490, 1266, 1113, 1073, 1011, 1000, 821, 782cm⁻¹ I-115 ¹HNMR(CDCl₃) δ 3.45(s, 3H), 3.75(s, 3H), 5.11(s, 2H), 6.45(s, 1H), 6.92(d, J=8.7Hz, 2H), 6.96(dd, J=8.4, 2.1Hz, 1H), 7.01(d, J=8.4Hz, 1H), 7.09(d, J=2.1Hz, 1H), 7.11(dd, J=8.7, 8.7Hz, 2H), 7.42(dd, J=8.7, 5.4Hz, 2H), 7.54(d, J=8.7Hz, 2H) IR(Nujol)3560, 3400, 1612, 1589, 1522, 1492, 1260.1225, 1116, 1068, 1006, 992, 841, 826, 803, 786cm ⁻¹

TABLE 31 I-116 ¹HNMR(CDCl₃) δ 3.45(s, 3H), 3.75(s, 3H), 5.23(s, 2H), 6.45(s, 1H), 6.92(d, J=8.7Hz, 2H), 6.97(brs, 2H), 7.11(brs, 1H), 7.31(dd, J=8.4, 2.1Hz, 1H), 7.46(d, J=8.4Hz, 1H), 7.47(d, J=2.1Hz, 1H), 7.54(d, J=8.7Hz, 2H) IR(Nujol)3460, 3359, 1610, 1594, 1522, 1490, 1264, 1164, 1110, 1072, 1008, 877, 824, 781cm⁻¹ I-117 ¹HNMR(CDCl₃) δ 3.45(s, 3H), 3.75(s, 3H), 3.84(s, 3H), 5.07(s, 2H), 6.45(s, 1H), 6.92(d, J=8.7Hz, 2H), 6.95(d, J=9.0Hz, 2H), 6.96(dd, J=8.4, 1.8Hz, 1H), 7.04(d, J=8.4Hz, 1H), 7.08(d, J=1.8Hz, 1H), 7.37(d, J=8.7Hz, 2H), 7.53(d, J=9.0Hz, 2H) IR(Nujol)3400, 1612, 1586, 1516, 1488, 1246, 1174, 1113, 1070, 1011, 823cm⁻¹ I-118 ¹HNMR(DMSO-d₆) δ 3.29(s, 3H), 3.64(s, 3H), 5.20(s, 2H), 6.39(s, 1H), 6.64(dd, J=8.4, 2.1Hz, 1H), 6.79(d, J=2.1Hz, 1H), 6.84(d, J=8.7Hz, 2H), 6.92(d, J=8.4Hz, 1H), 7.43(d, J=8.7Hz, 2H), 7.52(d, J=6.0Hz, 2H), 8.59(d, J=6.0Hz, 2H) IR(Nujol)3473, 3441, 1610, 1582, 1523, 1493, 1404, 1241, 1112, 1074, 1005, 816, 782cm⁻¹ I-119 ¹HNMR(CDCl₃) δ 3.45(s, 3H), 3.74(s, 3H), 5.27(s, 2H), 6.45(s, 1H), 6.92(dd, J=8.4, 1.8Hz, 1H), 6.93(d, J=8.7Hz, 2H), 7.11(d, J=8.4Hz, 1H), 7.12(d, J=1.8Hz, 1H), 7.31(m, 1H), 7.36(brd, J=7.5Hz, 1H), 7.53(d, J=8.7Hz, 2H), 7.77(ddd, J=7.5, 7.5, 1.8Hz, 1H), 8.66(d, J=5.0Hz, 1H) IR(Nujol)3555, 3467, 3342, 1608, 1597, 1586, 1522, 1466, 1210, 1117, 1080, 1016, 822, 761cm⁻¹ I-120 ¹HNMR(CDCl₃) δ 3.45(s, 3H), 3.74(s, 3H), 5.21(s, 2H), 6.46(s, 1H), 6.91(d, J=8.7Hz, 2H), 6.99(brs, 2H), 7.11(brs, 1H), 7.40(dd, J=7.5, 5.0Hz, 1H), 7.53(d, J=8.7Hz, 2H), 7.83(d, J=7.5Hz, 1H), 8.64(brd, J=5.0Hz, 1H), 8.74(brs, 1H) IR(Nujol)3342, 1609, 1586, 1522, 1489, 1253, 1118, 1074, 1010, 827, 782cm⁻¹ I-121 m.p. 166–168° C. ¹HNMR(CDCl₃) δ 3.45(s, 3H), 3.75(s, 3H), 4.77(d, J=6.3Hz, 2H), 6.22(t, J=6.3Hz, 1H), 6.93(d, J=8.7Hz, 2H), 6.93(d, J=8.7Hz, 1H), 6. 98(dd, J=8.7, 1.8Hz, 1H), 7.08(d, J=1.8Hz, 1H), 7.53(d, J=8.7Hz, 2H) IR(KBr)3474, 3411, 2957, 2930, 1615, 1589, 1569, 1523, 1492, 1407, 1286, 1263, 1230, 1113, 1070, 825cm⁻¹

TABLE 32 I-122 m.p. 190–192° C. ¹HNMR(CDCl₃) δ 2.56(s, 3H), 3.22(s, 3H), 3.56(s, 3H), 3.79(s, 3H), 5.17(s, 2H), 5.73(s, 1H), 6.84(s, 1H), 6.93(dd, J=8.1 and 1.9Hz, 1H), 7.02(d, J=8.1Hz, 1H), 7.05(d, J=1.9Hz, 1H), 7.37–7.45(m, 1H), 7.71(d, J=8.6Hz, 2H) IR(KBr)3512, 1519, 1484, 1367, 1174, 1150, 1078, 957, 870, 798cm⁻¹ I-123 foam ¹HNMR(CDCl₃) δ 3.08(s, 3H), 3.21(s, 3H), 3.44(s, 3H), 3.78(s, 3H), 5.15(s, 2H), 6.95(s, 1H), 7.11(d, J=8.7Hz, 1H), 7.33–7.47(m, 9H), 7.71 (d, J=8.7Hz, 2H), 13.3–14.5(brs, 1H) IR(KBr): 3422, 1735, 1702, 1520, 1471, 1366, 1175, 1150, 1118, 971, 954, 863, 807cm⁻¹ I-124 m.p. 258–259° C. (dec) ¹HNMR(DMSO-d₆) δ 3.32(s, 3H), 3.69(s, 3H), 5.10(2H, s), 6.65(dd, J=8.4, 2.1Hz, 1H), 6.79(d, J=2.1Hz, 1H), 6.86(d, J=8.4Hz, 2H), 6.90 (s, 1H), 6.94(d, J=8.4Hz, 1H), 7.30–7.54(m, 7H), 8.98(s, 1H), 9.63(s, 1H) IR(KBr): 3437, 3157, 1702, 1610, 1590, 1521, 1474, 1464, 1379, 1260, 1245, 1224, 1061, 1014, 952, 834, 793, 748, 698cm⁻¹ I-125 ¹HNMR(CDCl₃) δ 1.75(s, 3H), 1.81(s, 3H), 3.21(s, 3H), 3.41(s, 3H), 3.68(s, 3H), 3.77(s, 3H), 4.61(d, J=6.8Hz, 2H), 5.50(t, J=6.8Hz, 1H), 6.93(s, 1H), 7.02(d, J=8.5Hz, 1H), 7.27(d, J=8.5, 2.3Hz, 1H), 7.33(dd, J=2.3Hz, 1H), 7.38(d, J=8.6Hz, 2H), 7.71(d, J=8.6Hz, 2H) I-126 ¹HNMR(CDCl₃) δ 1.75(s, 3H), 1.81(s, 3H), 3.41(s, 3H), 3.65(s, 3H), 3.76(s, 3H), 4.59(d, J=6.6Hz, 2H), 5.06(s, 1H), 5.51(t, J=6.6Hz, 1H), 5.67(s, 1H), 6.83(dd, J=8.4, 2.1Hz, 1H), 6.87(s, 1H), 6.90–6.93(m, 3H), 6.98(d, J=2.1Hz, 1H), 7.54(d, J=9.0Hz, 2H) I-127 m.p. 116–117° C. ¹HNMR(DMSO-d₆) δ 1.72(s, 3H), 1.76(s, 3H), 3.32(s, 3H), 3.70(s, 3H), 4.53(d, J=7.1Hz, 2H), 5.48(t, J=7.1Hz, 1H), 6.65(dd, J=8.4, 2.1Hz, 1H), 6.73(d, J=2.1Hz, 1H), 6.86(d, J=8.6Hz, 2H), 6.88(d, J=8.4Hz, 1H), 6.93(s, 1H), 7.47(d, J=8.6Hz, 2H), 8.84(s, 1H), 9.62(s, 1H), 11.9–13.4 (brs, 1H) IR(KBr): 3446, 1703, 1611, 1593, 1520, 1471, 1380, 1260, 1225, 1081, 997, 952, 838cm⁻¹

TABLE 33 I-128 oil ¹HNMR(CDCl₃) δ 1.65(s, 3H), 1.78(s, 3H), 2.96(s, 3H), 3.22(s, 3H), 3.25(s, 3H)3.55(s, 3H), 3.79(s, 3H), 4.77(d, J=7.8Hz, 2H), 5.53(t, J=7.8Hz, 1H), 6.87(s, 1H), 7.39&7.67(ABq, J=8.7Hz, 4H), 7.70(d, J=2.1Hz, 1H), 7.86(d, J=2.1Hz, 1H), 10.36(s, 1H) IR(CHCl₃)1691, 1473, 1374, 1230, 1226, 1209, 1178, 1152, 1086, 969, 874, 805cm⁻¹ I-129 oil ¹HNMR(CDCl₃) δ 1.73(d, J=0.9Hz, 3H), 1.80(s, 3H), 2.89(s, 3H), 3.20(s, 3H), 3.22(s, 3H), 3.54(s, 3H), 3.79(s, 3H), 4.66(d, J=7.8Hz, 2H), 4.77(s, 2H), 5.55(m, 1H), 6.85(s, 1H), 7.39&7.68(ABq, J=9.0Hz, 4H), 7.39(d, J=2.1Hz, 1H), 7.44(d, J=2.1Hz, 1H) IR(CHCl₃)1475, 1372, 1230, 1178, 1151, 1085, 969, 874cm⁻¹ I-130 m.p. 189–190° C. ¹HNMR(CDCl₃) δ 1.36(s, 9H), 2.81(s, 3H), 3.22(s, 3H), 3.30(s, 3H), 3.56(s, 3H), 3.79(s, 3H), 6.86(s, 1H), 7.36–7.42(m, 3H), 7.54(d, J=1.8Hz, 1H), 7.67–7.72(m, 3H) IR(KBr)1472, 1363, 1331, 1179, 1153, 1082, 961, 950, 877, 846, 817, 791, 526cm⁻¹ I-131 m.p. 147–148° C. ¹HNMR(CDCl₃) δ 2.95(s, 3H), 3.18(s, 3H), 3.22(s, 3H), 3.55(s, 3H), 3.79(s, 3H), 5.28(s, 2H), 6.86(s, 1H), 7.38–7.44(m, 7H), 7.67(m, 2H), 7.75(d, J=2.1Hz, 1H), 7.83(d, J=2.1Hz, 1H) IR(KBr) 1687, 1512, 1472, 1365, 1352, 1234, 1201, 1180, 1151, 1082, 971, 947, 870, 846, 810, 794, 703, 523cm⁻¹ I-132 m.p. 122–124° C. ¹HNMR(CDCl₃) δ 1.68(s, 3H), 1.74(s, 3H), 2.80(s, 3H), 3.22(s, 3H), 3.28(s, 3H), 3.56(s, 3H), 3.62(d, J=7.8Hz, 2H), 3.78(s, 3H), 5.31(m, 1H), 6.85(s, 1H), 7.34(dd, J=8.1Hz, J=1.8Hz, 1H), 7.39&7.68(ABq, J=8.7Hz, 4H), 7.43(d, J=8.1Hz, 1H), 7.46(d, J=1.8Hz, 1H) IR(KBr) 1474, 1362, 1180, 1151, 1076, 1014, 968, 944, 870, 816, 799, 521cm⁻¹ I-133 ¹HNMR(CDCl₃) δ 1.73(d, J=0.9Hz, 3H), 1.82(s, 3H), 3.44(s, 3H), 3.75(s, 3H), 4.54(d, J=6.9Hz, 2H), 4.78(s, 2H), 5.30(s, 1H), 5.61(m, 1H), 5.67(s, 1H), 6.01(s, 1H), 6.45(s, 1H), 6.92&7.52(ABq, J=8.7Hz, 4H), 7.02(d, J=2.1Hz, 1H), 7.05(d, J=2.1Hz, 1H) IR(KBr)3428, 1612, 1522, 1483, 1458, 1403, 1362, 1334, 1304, 1266, 1226, 1174, 1116, 1083, 1024, 970, 938cm⁻¹

TABLE 34 I-134 m.p. 167–168° C. ¹HNMR(CDCl₃) δ 1.39(d, J=1.2Hz, 3H), 1.70(s, 3H), 3.36(d, J=8.1Hz, 2H), 3.45(s, 3H), 3.74(s, 3H), 4.98(s, 1H), 5.29(m, 1H), 5.96(s, 1H), 6.45(s, 1H), 6.78(s, 1H), 6.93&7.54(ABq, J=8.7Hz, 4H), 6.96(dd, J=7.8Hz, J=1.8Hz, 1H), 7.09(d, J=1.8Hz, 1H), 7.49(d, J=7.8Hz, 1H) IR(KBr)3413, 3365, 2931, 1611, 1552, 1520, 1502, 1475, 1455, 1441, 1402, 1360, 1323, 1262, 1227, 1206, 1182, 1170, 1162, 1114, 1100, 1081, 1052, 1014, 941, 835, 816, 587, 542cm⁻¹ I-135 m.p. 183–184° C. ¹HNMR(CDCl₃) δ 3.46(s, 3H), 3.74(s, 3H), 3.83(s, 3H), 4.78(m, 2H), 5.99(m, 1H), 6.44(m, 1H), 6.45(s, 1H), 6.92(d, J=8.7Hz, 2H), 6.94( dd, J=8.1, 1.8Hz, 1H), 7.00(d, J=8.1Hz, 1H), 7.10(d, J=1.8Hz, 1H), 7.53(d, J=8.7Hz, 2H) IR(KBr)3383, 2929, 1699, 1523, 1491, 1405, 1262, 1236, 1206, 1173, 1116, 1071, 1011, 822cm⁻¹ I-136 ¹HNMR(CD₃OD) δ 1.26(s, 3H), 1.29(s, 3H), 3.38(s, 3H), 3.68(s, 3H), 3.80(dd, J=8.4, 2.7Hz, 1H), 3.96(dd, J=9.6, 8.4Hz, 1H), 4.34(dd, J=9.6, 2.7Hz, 1H), 6.44(s, 1H), 6.80(dd, J=8.1, 1.8Hz, 1H), 6.85(d, J=8.7Hz, 2H), 6.86(d, J=1.8Hz, 1H), 7.96(d, J=8.1Hz, 1H), 7.46(d, J=8.7Hz, 2H) IR(Nujol)3367, 1612, 1588, 1523, 1489, 1254, 1226, 1115, 1072, 1013, 940, 814cm⁻¹ I-137 ¹HNMR(CD₃OD) δ 3.38(s, 3H), 3.68(s, 3H), 4.02(dd, J=11.0, 3.6Hz, 1H), 4.12(dd, J=11.0, 1.8Hz, 1H), 5.48(dd, J=3.6, 1.8Hz, 1H), 6.43 (s, 1H), 6.83–6.87(m, 3H), 6.85(d, J=8.7Hz, 2H), 7.46(d, J=8.7Hz, 2H) IR(Nujol)3410, 1612, 1588, 1522, 1487, 1269, 1231, 1114, 1071, 1011, 947, 824cm⁻¹ I-138 ¹HNMR(CD₃OD) δ 3.38(s, 3H), 3.68(s, 3H), 4.70(d, J=5.4Hz, 2H), 6.43(s, 1H), 6.80(dd, J=8.1, 2.1Hz, 1H), 6.85(d, J=8.4Hz, 2H), 6.88( d, J=2.1Hz, 1H), 6.98(d, J=8.1Hz, 1H), 7.46(d, J=8.4Hz, 2H), 7.62(t, J=5.4Hz, 1H) IR(Nujol)3368, 1612, 1589, 1523, 1489, 1253, 1226, 1114, 1072, 1011, 940, 825cm⁻¹ I-139 ¹HNMR(CDCl₃) δ 3.45(s, 3H), 3.74(s, 3H), 3.92(s, 3H), 4.75(d, J=5.1Hz, 2H), 6.45(s, 1H), 6.91(d, J=8.7Hz, 2H), 6.92(d, J=6.0Hz, 1H), 7.00(dd, J=6.0, 1.8Hz, 1H), 7.09(d, J=1.8Hz, 1H), 7.52(d, J=8.7Hz, 2H), 7.58(t, J=5.1Hz, 1H) IR(Nujol)3399, 1612, 1589, 1523, 1489, 1252, 1226, 1115, 1072, 1043, 1014, 941, 825cm⁻¹

TABLE 35 I-140 ¹HNMR(CD₃OD) δ 3.38(s, 3H), 3.68(s, 3H), 4.51(s, 2H), 4.71(d, J=5.4Hz, 2H), 6.43(s, 1H), 6.80(dd, J=8.4, 2.1Hz, 1H), 6.85(d, J=8.4Hz, 2H), 6.87(d, J=2.1Hz, 1H), 6.98(d, J=8.4Hz, 1H), 7.46(d, J=8.4Hz, 2H), 7.75(t, J=5.4Hz, 1H) IR(Nujol)3384, 1611, 1588, 1523, 1489, 1252, 1227, 1115, 1072, 1014, 824, 758cm⁻¹ I-141 ¹HNMR(CDCl₃) δ 3.45(s, 3H), 3.74(s, 3H), 4.76(d, J=5.1Hz, 2H), 5.15(s, 2H), 6.45(s, 1H), 6.86(d, J=8.4Hz, 1H), 6.92(d, J=8.7Hz, 2H), 6.94(dd, J=8.4, 2.1Hz, 1H), 7.08(d, J=2.1Hz, 1H), 7.31–7.40(m, 5H), 7.53(d, J=8.7Hz, 2H), 7.65(t, J=5.1Hz, 1H) IR(Nujol)3399, 1611, 1588, 1523, 1489, 1251, 1225, 1115, 1072, 1013, 940, 825cm⁻¹ I-142 ¹HNMR(CDCl₃·CD₃OD1:1) δ 3.26(s, 3H), 2.64(m, 4H), 3.13(m, 4H), 3.44(s, 3H), 3.73(s, 3H), 4.78(d, J=4.5Hz, 2H), 6.45(s, 1H), 6.90( d, J=8.7Hz, 2H), 6.90(dd, J=8.4, 2.1Hz, 1H), 6.99(d, J=2.1Hz, 1H), 7.00(d, J=8.4Hz, 1H), 7.12(t, J=4.5Hz, 1H), 7.49(d, J=8.7Hz, 2H) IR(Nujol)3492, 3297, 1607, 1561, 1523, 1486, 1247, 1224, 1113, 1011, 957, 828, 799cm⁻¹ I-143 ¹HNMR(CDCl₃) δ 3.09(m, 4H), 3.45(s, 3H), 3.74(s, 3H), 3.86(m, 4H), 4.82(d, J=4.2Hz, 2H), 6.44(s, 1H), 6.92(d, J=8.7Hz, 2H), 6.98(dd, J=8.4, 1.8Hz, 1H), 7.00(t, J=4.2Hz, 1H), 7.04(d, J=8.4Hz, 1H), 7.07(d, J=1.8Hz, 1H), 7.53(d, J=8.7Hz, 2H) IR(Nujol)3366, 1611, 1586, 1523, 1488, 1268, 1227, 1114, 1070, 1011, 823cm⁻¹ I-144 ¹HNMR(CDCl₃) δ 1.29(t, J=6.9Hz, 3H), 2.65(dd, J=15.9, 6.6Hz, 1H), 2.81(dd, J=15.9, 6.6Hz, 1H), 3.44(s, 3H), 3.75(s, 3H), 4.03(dd, J=11.4, 6.9Hz, 1H), 4.20(q, J=6.9Hz, 2H), 4.35(dd, J=11.4, 2.4Hz, 1H), 4.66(ddt, J=6.9, 6.6, 2.4Hz, 1H), 6.44(s, 1H), 6.92(d, J=8.7Hz, 2H), 6.96–7.01(m, 3H), 7.53(d, J=8.7Hz, 2H) I-145 oil ¹HNMR(CDCl₃) δ 1.68(s, 3H), 1.74(d, J=0.9Hz, 3H), 2.55(m, 2H), 3.44(s, 3H), 3.75(s, 3H), 4.04(t, J=7.2Hz, 2H), 4.97(brs, 1H), 5.23( m, 1H), 6.00(s, 1H), 6.45(s, 1H), 6.92&7.53(ABq, J=8.7Hz, 4H), 7.02(m, 1H), 7.17–7.22(m, 2H) IR(KBr)1613, 1525, 1490, 1475, 1463, 1454, 1402, 1304, 1269, 1231, 1112, 1072, 1019, 827cm⁻¹

TABLE 36 I-146 m.p. 256–257° C. ¹HNMR(DMSO-d₆) δ 3.35(s, 3H), 3.44(s, 3H), 3.74(s, 3H), 5.22(s, 2H), 7.06(s, 1H), 7.28–7.56(m, 11H), 7.69(s, 1H), 7.76(d, J=8.6Hz, 2H) IR(KBr): 3479, 3360, 1672, 1517, 1465, 1361, 1339, 1295, 1261, 1228, 1172, 1144, 1118, 1013, 957, 870, 852, 804, 751cm⁻¹ I-147 m.p.. 163–164° C. ¹HNMR(CDCl₃) δ 1.74(s, 3H), 1.81(s, 3H), 3.43(s, 3H), 3.74(s, 3H), 4.58(d, J=6.8Hz, 2H), 5.50(t, J=6.8Hz, 1H), 5.80(s, 1H), 6.37(s, 1H), 6.86–6.95(m, 5H), 6.90(d, J=8.6Hz, 2H), 6.99(s, 1H), 7.49(d, J=8.6Hz, 2H) IR(KBr): 3533, 3412, 3350, 1655, 1609, 1588, 1519, 1469, 1373, 1274, 1245, 1227, 1131, 1082, 1060, 999, 954, 838cm⁻¹ I-148 ¹HNMR(CDCl₃) δ 2.88(s, 3H), 3.22(s, 3H), 3.54(s, 3H), 3.77(s, 3H), 5.35(m, 2H), 6.85(s, 1H), 7.24(d, J=9.0Hz, 1H), 7.39(d, J=8.7Hz, 2H), 7.42–7.46(m, 5H), 7.65(d.d, J=9.0&2.1Hz, 1H), 7.68(d, J=8.7Hz, 2H), 8.26(d, J=2.1Hz, 1H) I-149 ¹HNMR(CDCl₃) δ 1.80(s, 3H), 1.85(s, 3H), 3.43(s, 3H), 3.74(s, 3H), 4.80(d, J=6.9Hz, 2H), 5.76(t, J=6.9Hz, 1H), 6.46(s, 1H), 6.92(d, J=8.4Hz, 2H), 7.14(d, J=8.7Hz, 1H), 7.49(d, J=8.4Hz, 2H)7.70(d.d, J=8.7&2.1Hz, 1H), 8.28(d, J=2.1Hz, 1H) IR(KBr)3472, 1707, 1671, 1610, 1520, 1482, 1460, 1426, 1269, 1226, 1119, 1076, 1012cm⁻¹ I-150 ¹HNMR(CDCl₃) δ 1.76(s, 3H), 1.81(s, 3H), 2.63(s, 3H), 3.21(s, 3H), 3.55(s, 3H), 3.77(s, 3H), 4.62(d, J=6.3Hz, 2H), 4.73(s, 2H), 5.50(t, J=6.3Hz, 1H), 6.84(s, 1H), 6.99(d, J=9.0Hz, 1H), 7.51–7.42(m, 9H), 7.70(d, J=9.0Hz, 2H) IR(KBr)3432, 1607, 1512, 1479, 1364, 1234, 1176, 1151, 1079, 1016cm⁻¹ I-151 ¹HNMR(CDCl₃) δ 1.58(s, 3H), 1.81(s, 3H), 3.45(s, 3H), 3.73(s, 3H), 4.61(d, J=6.6Hz, 2H), 4.72(s, 2H), 5.52(t, J=6.6Hz, 1H), 6.45(s, 1H), 6.91(d, J=8.7Hz, 2H), 6.98(d, J=8.4Hz, 1H), 7.36(d.d, J=8.4&2.1Hz, 1H), 7.38(d, J=2.1Hz, 1H), 7.50(d, J=8.4Hz, 2H) IR(KBr)3580, 3411, 1611, 1521, 1485, 1464, 1397, 1233, 1113, 1077, 1024, 1001cm⁻¹ I-152 ¹HNMR(CDCl₃) δ 3.50(s, 3H), 3.77(s, 3H), 5.15(s, 2H), 5.72(s, 1H), 6.03(s, 2H), 6.71(d.d, J=8.4&2.1Hz, 1H), 6.91(d, J=8.4Hz, 1H), 6.97 (s, 1H), 6.98(d, J=8.4Hz, 1H), 7.07(s, 1H), 7.09(d.d, J=8.4&2.1Hz, 1H), 7.16(d, J=2.1Hz, 1H), 7.34–7.50(m, 5H), 989(s, 1H) IR(KBr)3446, 1697, 1587, 1511, 1470, 1383, 1285, 1240, 1127, 1036cm⁻¹

TABLE 37 I-153 ¹HNMR(CDCl₃) δ 3.78(s, 3H), 3.79(s, 3H), 4.87(s, 1H), 5.16(s, 2H), 5.70(s, 1H), 6.88–6.91(m, 2H), 6.97(s, 1H), 7.00(s, 1H), 6.99(d, J=8.4Hz, 1H), 7.08(dd, J=2.1, 8.4Hz, 1H), 7.23(d, J=2.1Hz, 1H), 7.34–7.49(m, 7H) I-154 ¹HNMR(CDCl₃) δ 1.69(s, 3H), 1.74(s, 3H), 2.51–2.58(m, 2H), 3.19(s, 3H), 3.21(s, 3H), 3.79(s, 3H), 3.80(s, 3H), 4.07(t, J=6.9Hz, 2H), 5.18–5.27(m, 1H), 6.92(s, 1H), 6.95(s, 1H), 7.05(d, J=8.7Hz, 1H), 7.32–7.37(m, 2H), 7.49(dd, J=2.1, 8.7Hz, 1H), 7.58(d, J=2.1Hz, 1H), 7.60–7.64(m, 2H) I-155 ¹HNMR(CDCl₃) δ 1.69(s, 3H), 1.75(s, 3H), 2.53(q, J=6.9Hz, 2H), 3.77(s, 3H), 3.78(s, 3H), 4.07(t, J=6.9Hz, 2H), 4.97(s, 3H), 5.20–5.25 (m, 1H), 5.71(s, 1H), 6.87–6.93(m, 3H), 7.07(dd, J=1.8, 8.4Hz, 1H), 7.20(d, J=1.8Hz, 1H), 7.45–7.50(m, 2H) I-156 m.p. 163–175° C. ¹HNMR(CDCl₃) δ 2.76(s, 3H), 3.19(s, 3H), 3.22(s, 3H), 3.54(s, 3H), 3.79(s, 3H), 5.20(s, 2H), 5.68(s, 1H), 6.84(s, 1H), 6.97(d, J=1.8Hz, 1H), 6.99(d, J=1.8Hz, 1H), 7.37–7.47(m, 7H), 7.68(m, 2H) IR(KBr)3436, 1480, 1415, 1391, 1363, 1233, 1178, 1151, 1079, 1024, 969, 953, 875, 801, 522cm⁻¹ I-157 m.p. 176–178° C. ¹HNMR(CDCl₃) δ 2.08(s, 3H), 2.40, (s, 3H), 2.72(s, 3H), 3.21(s, 3H), 3.22(s, 3H), 3.55(s, 3H), 3.79(s, 3H), 5.13(s, 2H), 6.86(s, 1H), 7.39a nd 7.68(ABq, J=8.7Hz, 4H), 7.47(d, J=2.1Hz, 1H), 7.49(d, J=2.1Hz, 1H) IR(KBr)1770, 1747, 1477, 1391, 1366, 1235, 1180, 1152, 1077, 873, 799, 522cm⁻¹ I-158 m.p. 175–177° C. ¹HNMR(CDCl₃) δ 2.87(s, 3H), 3.13(s, 6H), 3.22(s, 3H), 3.55(s, 3H), 3.81(s, 3H), 5.22(s, 2H), 6.86(s, 1H), 7.38–7.45(m, 7H), 7.51–7.53( m, 2H), 7.67(m, 2H) IR(KBr)1479, 1367, 1180, 1151, 1080, 1019, 966, 876, 798, 525cm⁻¹

TABLE 38 I-159 foam ¹HNMR(CDCl₃) δ 2.44(s, 3H), 3.21(s, 3H), 3.54(s, 3H), 3.76(s, 3H), 3.79(s, 3H), 4.77(s, 2H), 5.24(s, 2H), 6.83(s, 1H), 6.90–7.00(m, 3H), 7.30–7.48(m, 5H), 7.37(d, J=8.8Hz, 2H), 7.69(d, J=8.8Hz, 2H) IR(KBr): 1758, 1519, 1481, 1365, 1236, 1176, 1150, 1079, 1013, 963, 872, 798cm⁻¹ I-160 m.p.. 146–147° C. ¹HNMR(DMSO-d₆) δ 3.31(s, 3H), 3.65(s, 3H), 4.63(s, 2H), 5.15(s, 2H), 6.40(s, 1H), 6.83–6.90(m, 4H), 7.05(d, J=8.4Hz, 1H), 7.32–7.52 (m, 7H), 8.57(s, 1H), 9.50(s, 1H), 12.0–13.9(brs, 1H) IR(KBr): 3422, 1728, 1611, 1524, 1489, 1455, 1405, 1247, 1142, 1118, 1080, 1012, 818, 749, 742, 698cm⁻¹ I-161 ¹HNMR(CDCl₃) δ 1.76(s, 3H), 1.79(s, 3H), 2.57(s, 3H), 3.21(s, 3H), 3.56(s, 3H), 3.77(s, 3H), 3.80(s, 3H), 4.64(d, J=6.5Hz, 2H), 4.74(s, 2H), 5.54(t, J=6.5Hz, 1H), 6.83(s, 1H), 6.88(d, J=1.5Hz, 1H), 7.02–7.03(m, 2H), 7.38(d, J=8.7Hz, 2H), 7.69(d, J=8.7Hz, 2H) I-162 m.p. 147–149° C. ¹HNMR(DMSO-d₆) δ 1.73(s, 3H), 1.77(s, 3H), 3.30(s, 3H), 3.65(s, 3H), 4.57(d, J=6.6Hz, 2H), 4.60(s, 2H), 5.86(t, J=6.6Hz, 1H), 6.40(s, 1H), 6.80(d, J=1.7Hz, 1H), 6.84(d, J=8.7Hz, 2H), 6.87(dd, J=8.7Hz, 1H), 6.99(d, J=8.7Hz, 1H), 7.43(d, J=8.7Hz, 2H), 8.56(s, 1H), 9.51( s, 1H), 12.8(brs, 1H) IR(KBr): 3483, 3376, 1737, 1612, 1523, 1489, 1460, 1397, 1271, 1231, 1175, 1120, 1072, 1012, 904, 820cm⁻¹ I-163 m.p. 144–145° C. ¹HNMR(CDCl₃) δ 3.04(s, 3H), 3.20(s, 3H), 3.59(s, 3H), 3.75(s, 3H), 4.90(s, 2H), 5.16(s, 2H), 5.65(s, 1H), 6.67(s, 1H), 6.92(dd, J=2.1, 8.4Hz, 1H), 7.00(d, J=8.4Hz, 1H), 7.06(d, J=2.1Hz, 1H), 7.26–7.47(m, 7H), 7.61–7.66(m, 2H) IR(KBr)3600–3200(br), 1517, 1477, 1449, 1382, 1361, 1277, 1235, 1199, 1150, 1112, 1079, 1064, 1010, 997cm⁻¹ I-164 m.p. 80–83° C. ¹HNMR(CDCl₃) δ 2.99(s, 3H), 3.12(s, 3H), 3.20(s, 3H), 3.58(s, 3H), 3.75(s, 3H), 4.93(s, 3H), 5.18(s, 2H), 6.67(s, 1H), 7.12(d, J=8.7Hz, 1H), 7.34–7.49(m, 9H), 7.60–7.65(m, 2H)

TABLE 39 I-165 m.p. 148–151° C. ¹HNMR(CDCl₃) δ 3.03(s, 3H), 3.57(s, 3H), 3.74(s, 3H), 4.89(s, 1H), 4.90(s, 2H), 5.15(s, 2H), 5.64(s, 1H), 6.67(s, 1H), 6.88–6.93(m, 3H), 6.99(d, J=8.4Hz, 1H), 7.06(d, J=1.8Hz, 1H), 7.20–7.49(m, 7H) IR(KBr)3600–3200(br), 1609, 1590, 1519, 1477, 1459, 1381, 1253, 1216, 1156, 1111, 1077, 1066, 1012cm⁻¹ I-166 m.p. 199° C. ¹HNMR(CDCl₃) δ 3.10(s, 3H), 3.21(s, 3H), 3.44(s, 3H), 3.76(s, 3H), 5.17(s, 2H), 6.03(s, 1H), 6.44(s, 1H), 7.14(d, J=8.4Hz, 1H), 7.36–7.49 (m, 8H), 7.52(d, J=2.1Hz, 1H), 7.67–7.72(m, 2H) IR(KBr)3600–3200(br), 1520, 1486, 1362, 1183, 1152, 1110, 971cm⁻¹ I-167 m.p. 113–115° C. ¹HNMR(CDCl₃) δ 0.76(t, J=7.2Hz, 3H), 1.46–1.55(m, 2H), 3.11(s, 3H), 3.20(s, 1H), 3.63(s, 1H), 3.71(t, J=6.6Hz, 2H), 5.18(s, 2H), 6.64 (s, 1H), 7.11(d, J=8.7Hz, 1H), 7.33–7.50(m, 9H), 7.60–7.65(m, 2H) IR(KBr)1517, 1475, 1365, 1345, 1293, 1233, 1177, 1149, 1109, 1079, 1017, 956cm⁻¹ I-168 m.p. 56–58° C. ¹HNMR(CDCl₃) δ 0.76(t, J=7.5Hz, 3H), 1.44–1.56(m, 2H), 3.61(s, 3H), 3.71(t, J=6.6Hz, 2H), 3.74(s, 3H), 4.86(s, 1H), 5.15(s, 2H), 5.63 (s, 1H), 6.65(s, 1H), 6.88–6.93(m, 3H), 6.98(d, J=8.4Hz, 1H), 7.04(d, J=1.8Hz, 1H), 7.37–7.50(m, 7H) IR(KBr)3600–3200(br), 1611, 1590, 1519, 1476, 1404, 1379, 1252, 1230, 1110, 1078, 1015cm⁻¹ I-169 m.p. 101–103° C. ¹HNMR(CDCl₃) δ 0.77(t, J=7.5Hz, 3H), 1.44–1.55(m, 2H), 1.76(s, 3H), 1.81(s, 3H), 3.20(s, 3H), 3.21(s, 3H), 3.63(s, 3H), 3.71(t, J=6.6Hz, 2H), 3.75(s, 3H), 4.63(d, J=6.6Hz, 2H), 5.48–5.53(m, 1H), 6.64(s, 1H), 7.04(d, J=8.4Hz, 1H), 7.32–7.38(m, 3H), 7.42(d, J=2.1Hz, 1H), 7.60–7.65(m, 2H) IR(KBr)1514, 1473, 1370, 1359, 1290, 1233, 1174, 1149, 1107, 970cm⁻¹

TABLE 40 I-170 m.p. 64–66° C. ¹HNMR(CDCl₃) δ 0.77(t, J=7.5Hz, 3H), 1.44–1.55(m, 2H), 1.76(s, 3H), 1.81(s, 3H), 3.20(s, 3H), 3.21(s, 3H), 3.63(s, 3H), 3.71(t, J=6.6Hz, 2H), 3.75(s, 3H), 4.63(d, J=6.6Hz, 2H), 5.48–5.53(m, 1H), 6.64(s, 1H), 7.04(d, J=8.4Hz, 1H), 7.32–7.38(m, 3H), 7.42(d, J=2.1Hz, 1H), 7.60–7.65(m, 2H)IR(KBr)3600–2800(br), 1612, 1590, 1520, 1475, 1462, 1405, 1381, 1285, 1244, 1226, 1110, 1079, 988cm⁻¹ I-171 m.p. 148–150° C. ¹HNMR(CDCl₃) δ 1.74(d, J=0.9Hz, 3H), 1.80(s, 3H), 2.88(s, 3H), 3.22(s, 3H), 3.23(s, 6H), 3.55(s, 3H), 3.80(s, 3H), 4.72(d, J=7.5Hz, 2H), 5.55(m, 1H), 6.85(s, 1H), 7.39&7.67(ABq, J=8.7Hz, 4H), 7.40(s, 2H) IR(KBr)1514, 1479, 1411, 1366, 1179, 1152, 1079, 1022, 968, 875, 799, 525cm⁻¹ I-172 ¹HNMR(CDCl₃) δ 0.94(t, J=7.2Hz, 3H), 1.45(tq, J=7.2, 7.2Hz, 2H), 2.13(m, 2H), 3.46(s, 3H), 3.74(s, 3H), 4.68(d, J=5.4Hz, 2H), 5.72 (m, 2H), 6.45(s, 1H), 6.92(d, J=8.7Hz, 2H), 6.96(brs, 2H), 7.07(brs, 1H), 7.53(d, J=8.7Hz, 2H) I-173 ¹HNMR(CDCl₃) δ 1.76(brd, J=6.3Hz, 3H), 3.46(s, 3H), 3.74(s, 3H), 4.70(d, J=5.4Hz, 2H), 5.77(m, 2H), 6.45(s, 1H), 6.91(d, J=8.7Hz, 2H), 6.96(brs, 2H), 7.07(brs, 1H), 7.53(d, J=8.7Hz, 2H) IR(Nujol)3350, 1613, 1587, 1523, 1491, 1287, 1261, 1238, 1114, 1071, 1011, 936, 820, 783cm⁻¹ I-174 ¹HNMR(CDCl₃) δ 3.45(s, 3H), 3.76(s, 3H), 4.56(s, 2H), 5.55(s, 1H), 6.45(s, 1H), 6.93(d, J=8.7Hz, 2H), 7.01(d, J=8.4Hz, 1H), 7.08(dd, J=8.4, 2.1Hz, 1H), 7.27(d, J=2.1Hz, 1H), 7.54(d, J=8.7Hz, 2H) I-175 ¹HNMR(CDCl₃) δ 3.45(s, 3H), 3.74(s, 3H), 4.82(dd, J=6.6, 1.5Hz, 2H), 5.28(d, J=10.5Hz, 1H), 5.35(d, J=16.5Hz, 1H), 5.75(dt, J=10.8, 6.6Hz, 1H), 6.26(dd, J=10.5, 10.5Hz, 1H), 6.45(s, 1H), 6.66(ddd, J=16.5, 10.5, 10.5Hz, 1H), 6.92(d, J=8.7Hz, 2H), 6.96(m, 2H), 7.07(brs, 1H), 7.53(d, J=8.7Hz, 2H) IR(Nujol)3399, 1611, 1591, 1523, 1489, 1248, 1226, 1113, 1071, 1009, 825cm⁻¹

TABLE 41 I-176 ¹HNMR(CDCl₃) δ 1.59(m, 6H), 2.17(m, 2H), 2.24, (m, 2H), 2.71(s, 3H), 3.21(s, 3H), 3.24(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 4.65(d, J=7.2Hz, 2H), 5.43(t, J=7.2Hz, 1H), 6.84(s, 1H), 7.10(d, J=8.4Hz, 1H), 7.34(dd, J=8.4, 2.1Hz, 1H), 7.38(d, J=8.7Hz, 2H), 7.39(d, J=2.1Hz, 1H), 7.68(d, J=8.7Hz, 2H) I-177 m.p. 177–178° C. ¹HNMR(CDCl₃) δ 2.31(t, J=5.7Hz, 2H), 2.39(t, J=5.7Hz, 2H), 2.76(s, 3H), 3.21(s, 3H), 3.24(s, 3H), 3.56(s, 3H), 3.70(t, J=5.7Hz, 2H), 3.73(t, J=5.7Hz, 2H), 3.78(s, 3H), 4.67(d, J=6.6Hz, 2H), 5.57(t, J=6.6Hz, 1H), 6.84(s, 1H), 7.09(d, J=8.4Hz, 1H), 7.35(dd, J=8.4, 2.1Hz, 1H), 7.38(d, J=8.7Hz, 2H), 7.39(d, J=2.1Hz, 1H), 7.67(d, J=8.7Hz, 2H) IR(KBr)2940, 1519, 1481, 1362, 1178, 1152, 1079, 818cm⁻¹ I-178 ¹HNMR(CDCl₃) δ 1.04(t, J=7.5Hz, 3H), 1.05(t, J=7.5Hz, 3H), 2.12(q, J=7.5Hz, 2H), 2.16(q, J=7.5Hz, 2H), 2.71(s, 3H), 3.21(s, 3H), 3.24 (s, 3H), 3.56(s, 3H), 3.78(s, 3H), 4.67(d, J=6.6Hz, 2H), 5.45(t, J=6.6Hz, 1H), 6.84(s, 1H), 7.11(d, J=8.4Hz, 1H), 7.35(dd, J=8.4, 2.4Hz, 1H), 7.38(d, J=8.7Hz, 2H), 7.39(d, J=2.4Hz, 1H), 7.68(d, J=8.7Hz, 2H) I-179 ¹HNMR(CDCl₃) δ 1.05(t, J=7.5Hz, 3H), 1.76(s, 3H), 2.10(q, J=7.5Hz, 2H), 2.71(s, 3H), 3.21(s, 3H), 3.24(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 4.66(d, J=6.9Hz, 2H), 5.48(t, J=6.9Hz, 1H), 6.84(s, 1H), 7.10(d, J=8.4Hz, 1H), 7.34(dd, J=8.4, 2.1Hz, 1H), 7.38(d, J=8.7Hz, 2H), 7.39 (d, J=2.1Hz, 1H), 7.68(d, J=8.7Hz, 2H) I-180 ¹HNMR(CDCl₃) δ 1.76(s, 3H), 1.80(s, 6H), 2.72(s, 3H), 3.21(s, 3H), 3.21(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 4.61(s, 2H), 6.84(s, 1H), 7.10 (d, J=8.4Hz, 1H), 7.34(dd, J=8.4, 2.1Hz, 1H), 7.38(d, J=8.7Hz, 2H), 7.39(d, J=2.1Hz, 1H), 7.68(d, J=8.7Hz, 2H) I-181 m.p. 157–158° C. ¹HNMR(CDCl₃) δ 1.55–1.65(m, 6H), 2.18(m, 2H), 2.23(m, 2H), 3.46(s, 3H), 3.74(s, 3H), 4.63d, J=7.2Hz, 2H), 5.47(t, J=7.2Hz, 1H), 6.45 (s, 1H), 6.91(d, J=8.4Hz, 2H), 6.96(br.s, 2H), 7.06(br.s, 1H), 7.52(d, J=8.4Hz, 2H) IR(KBr)3410, 2924, 2854, 1609, 1567, 1523, 1490, 1462, 1405, 1254, 1221, 1198, 1119, 1069, 824, 813cm⁻¹

TABLE 42 I-182 m.p. 219–221° C. ¹HNMR(DMSO-d₆) δ 2.22(t, J=5.4Hz, 2H), 2.32(t, J=5.4Hz, 2H), 3.30(s, 3H), 3.56(t, J=5.4Hz, 2H), 3.61(t, J=5.4Hz, 2H), 3.64(s, 3H), 4.59(d, J=6.6Hz, 2H), 5.54(t, J=6.6Hz, 1H), 6.39(s, 1H), 6.64(dd, J=8.4, 2.1Hz, 1H), 6.73(d, J=2.1Hz, 1H), 6.84(d, J=8.7Hz, 2H), 6.89(d, J=8.4Hz, 1H), 7.43(d, J=8.4Hz, 2H) IR(KBr)3392, 2948, 1609, 1586, 1522, 1492, 1271, 1239, 1219, 1118, 1076, 1007, 818cm⁻¹ I-183 m.p. 149–150° C. ¹HNMR(CDCl₃) δ 1.03(t, J=7.5Hz, 3H), 1.07(t, J=7.5Hz, 3H), 2.13(q, J=7.5Hz, 2H), 2.15(q, J=7.5Hz, 2H), 3.46(s, 3H), 3.75(s, 3H), 4.64(d, J=6.6Hz, 2H), 5.48(t, J=6.6Hz, 1H), 6.45(s, 1H), 6.92(d, J=8.7Hz, 2H), 6.97(dd, J=7.8, 1.5Hz, 1H), 6.97(d, J=7.8Hz, 1H), 7.06(d, J=1.5Hz, 1H), 7.52(d, J=8.7Hz, 2H) IR(KBr)3398, 2963, 2934, 1671, 1610, 1523, 1493, 1465, 1407, 1259, 1224, 1118, 1071, 813cm⁻¹ I-184 m.p. 217–218° C. ¹HNMR(CDCl₃) δ 3.86(s, 3H), 5.16(s, 2H), 5.72(s, 1H), 6.97–7.01(m, 3H), 7.12(dd, J=2.4, 8.4Hz, 1H), 7.26(d, J=2.4Hz, 1H), 7.34–7.47 (m, 5H), 7.54–7.58(m, 2H), 7.60(s, 4H) IR(KBr)3600–3200(br), 1605, 1590, 1493, 1298, 1282, 1253, 1206, 1183, 1022cm⁻¹ I-185 ¹HNMR(CDCl₃) δ 1.21(t, J=6.9Hz, 3H), 1.77(s, 3H), 1.82(s, 3H), 2.38–2.46(m, 2H), 2.72–2.84(m, 2H), 3.18(s, 3H), 3.21(s, 3H), 3.35(s, 3H), 3.70(s, 3H), 4.06(q, J=6.9Hz, 2H), 4.63(d, J=6.6Hz, 2H), 5.52(t, J=6.6Hz, 1H), 6.75(s, 1H), 7.07(d, J=8.4Hz, 1H), 7.13(d.d, J=8.4& 2.1Hz, 1H), 7.21(d, J=2.1Hz, 1H), 7.37(d, J=9.0Hz, 2H), 7.69(d, J=9.0Hz, 2H) IR(KBr)1727, 1517, 1469, 1364, 1291, 1234, 1179, 1152, 1118, 1080, 1003cm⁻¹ I-186 ¹HNMR(CDCl₃) δ 1.76(s, 3H), 1.82(s, 3H), 2.42–2.53(m, 2H), 2.72–2.86(m, 2H), 3.35(s, 3H), 3.69(s, 3H), 4.61(d, J=6.6Hz, 2H), 5.53(t, J=6.6Hz, 1H), 5.71(s, 1H), 6.68(d.d, J=8.4&2.1Hz, 1H), 6.76(s, 1H), 6.81(d, J=2.1Hz, 1H), 6.91(d, J=8.4Hz, 2H), 6.92(d, J=8.4Hz, 1H), 7.52(d, J=8.4Hz, 2H) IR(KBr)3419, 1707, 1612, 1518, 1472, 1390, 1225, 1078cm⁻¹

TABLE 43 I-187 ¹HNMR(CDCl₃) δ 2.55(s, 3H), 3.54(s, 3H), 3.78(s, 3H), 5.18(s, 1H), 6.85(s, 1H), 6.91(d.d, J=8.4&2.1Hz, 1H), 7.03(d, J=8.4Hz, 1H), 7.04 (d, J=2.1Hz, 1H), 7.33–7.48(m, 5H), 7.71(d, J=8.4Hz, 2H), 7.72(d, J=8.4Hz, 2H) IR(KBr)3442, 1617, 1517, 1485, 1485, 1394, 1357, 1331, 1171, 1124, 1077, 1067, 1016cm⁻¹ I-188 ¹HNMR(CDCl₃) δ 2.68(s, 3H), 3.13(s, 3H), 3.54(s, 3H), 3.79(s, 3H), 5.19(s, 2H), 6.86(s, 1H), 7.16(d, J=8.7Hz, 1H), 7.31–7.50(m, 7H), 7.72 (d, J=8.7Hz, 2H), 7.76(d, J=8.7Hz, 2H) IR(KBr)1614, 1513, 1482, 1366, 1324, 1177, 1120, 1079, 1065, 1016cm⁻¹ I-189 ¹HNMR(CDCl₃) δ 2.68(s, 3H), 3.13(s, 3H), 3.54(s, 3H), 3.79(s, 3H), 5.19(s, 2H), 6.86(s, 1H), 7.16(d, J=8.7Hz, 1H), 7.31–7.50(m, 7H), 7.72 (d, J=8.7Hz, 2H), 7.76(d, J=8.7Hz, 2H) IR(KBr)1614, 1513, 1482, 1366, 1324, 1177, 1120, 1079, 1065, 1016cm⁻¹ I-190 ¹HNMR(CDCl₃) δ 1.76(s, 3H), 1.82(s, 3H), 3.46(s, 3H), 3.76(s, 3H), 4.62(d, J=8.4Hz, 2H), 5.53(t, J=8.4Hz, 1H), 5.71(s, 1H), 5.85(s, 1H), 6.46(s, 1H), 6.94(d.d, J=8.1&1.8Hz, 1H), 6.98(d, J=8.1Hz, 1H), 7.05(d, J=1.8Hz, 1H), 7.71(d, J=8.1Hz, 2H), 7.77(d, J=8.1Hz, 2H) IR(KBr)3552, 3505, 3466, 1613, 1509, 1487, 1397, 1324, 1288, 1245, 1163, 1110, 1065cm⁻¹ I-191 ¹HNMR(CDCl₃) δ 3.02(s, 6H), 3.48(s, 3H), 3.76(s, 3H), 5.15(s, 2H), 5.67(s, 1H), 5.95(s, 1H), 6.47(s, 1H), 6.81(d, J=8.7Hz, 2H), 6.96(d.d, J=8.4&2.1Hz, 1H), 7.04(d, J=8.4Hz, 1H), 7.10(d, J=2.1Hz, 1H), 7.31–7.49(m, 5H), 7.55(d, J=8.7Hz, 2H) IR(KBr)3543, 3500, 1605, 1526, 1486, 1459, 1245, 1198, 1110, 1070, 999cm⁻¹ I-192 mp 122–124° C. ¹HNMR(CDCl₃) δ 2.70(brs, 3H), 3.55–3.60(br, 2H), 3.60(s, 3H), 3.75(s, 3H), 3.81–3.83(m, 2H), 3.87(s, 3H), 5.15(s, 2H), 5.68(s, 1H), 6.69 (s, 1H), 6.94(dd, J=2.1, 8.4Hz, 1H), 6.97–7.03(m, 3H), 7.07(d, J=1.8Hz, 1H), 7.38–7.48(m, 5H), 7.51–7.56(m, 2H) IR(KBr)3600–2800(br), 1607, 1597, 1550, 1518, 1477, 1462, 1452, 1392, 1289, 1248, 1228, 1175, 1122, 1096, 1084, 1015cm⁻¹

TABLE 44 I-193 m.p. 160–163° C. ¹HNMR(CDCl₃) δ 3.60(s, 3H), 3.60–3.64(br, 2H), 3.76(s, 3H), 3.77–3.80(m, 2H), 5.15(s, 2H), 5.69(s, 1H), 5.88(s, 1H), 6.69(s, 1H), 6.90–6.94 (m, 3H), 7.02(d, J=8.4Hz, 1H), 7.08(d, J=2.1Hz, 1H), 7.38–7.51(m, 7H) IR(KBr)3600–3200(br), 1613, 1588, 1519, 1477, 1462, 1397, 1256, 1189, 1117, 1078, 1011cm⁻¹ I-194 ¹HNMR(CDCl₃) δ 3.02(s, 6H), 3.11(s, 3H), 3.50(s, 3H), 3.72(s, 3H), 4.43(brs, 1H), 4.58(brs, 1H), 5.18(s, 2H), 6.82(d, J=8.7Hz, 2H), 6.92 (s, 1H), 7.16(d, J=9.3Hz, 1H), 7.31–7.51(m, 7H), 7.55(d, J=8.7Hz, 2H) IR(KBr)3432, 1611, 1526, 1476, 1356, 1291, 1232, 1186, 1117, 1079, 1012cm⁻¹ I-195 m.p. 157–158° C. ¹HNMR(CDCl₃) δ 3.10(s, 3H), 3.21(s, 3H), 3.56(s, 3H), 3.69(s, 3H), 3.76(s, 3H), 4.47(s, 2H), 5.17(s, 2H), 6.68(s, 1H), 7.12(d, J=8.2Hz, 1H), 7.34–7.50(m, 9H), 7.63(d, J=8.6Hz, 2H) IR(KBr): 1748, 1517, 1476, 1366, 1232, 1150, 1114, 968, 873, 812, 791, 750, 707cm⁻¹ I-196 m.p. 189–191° C. (dec) ¹HNMR(DMSO-d₆) δ 3.45(s, 3H), 3.67(s, 3H), 4.25(s, 2H), 5.12(s, 2H), 6.66(dd, J=8.4, 2.0Hz, 1H), 6.69(s, 1H), 6.77(d, J=2.0Hz, 1H), 6.80 (d, J=8.6Hz, 2H), 6.98(d, J=8.4Hz, 1H), 7.33–7.54(m, 7H), 9.01(s, 1H), 9.54(brs, 1H) IR(KBr): 3422, 3245, 1733, 1611, 1596, 1522, 1478, 1400, 1262, 1248, 1222, 1207, 1130, 1084, 1011, 836, 781, 744, 699cm⁻¹ I-197 m.p. 151–152° C. ¹HNMR(CDCl₃) δ 1.76(s, 3H), 1.81(s, 3H), 3.20(s, 3H), 3.21(s, 3H), 3.56(s, 3H), 3.70(s, 3H), 3.75(s, 3H), 4.47(s, 2H), 4.63(d, J=6.9Hz, 2H), 5.51(t, J=6.9Hz, 1H), 6.68(s, 1H), 7.05(d, J=8.4Hz, 1H), 7.36(dd, J=8.4, 2.1Hz, 1H), 7.36(d, J=8.9Hz, 2H), 7.41(d, J=2.1Hz, 1H), 7.63 (d, J=8.9Hz, 2H) IR(KBr): 1751, 1517, 1475, 1366, 1234, 1150, 1113, 968, 872, 812, 707cm⁻¹

TABLE 45 I-198 m.p. 155–156° C. ¹HNMR(DMSO-d₆) δ 1.72(s, 3H), 1.76(s, 3H), 3.42(s, 3H), 3.67(s, 3H), 4.25(s, 2H), 4.54(d, J=6.8Hz, 2H), 5.49(t, J=6.8Hz, 1H), 6.65(dd, J=8.4, 1.9Hz, 1H), 6.69(s, 1H), 6.73(d, J=1.9Hz, 1H), 6.84(d, J=8.4Hz, 2H), 7.36(d, J=8.4Hz, 1H), 7.41(d, J=8.4Hz, 2H), 8.85(s, 1H), 9.55(s, 1H), 11.2–13.6(brs, 1H) IR(KBr): 3411, 3243, 1733, 1611, 1594, 1522, 1477, 1398, 1247, 1207, 1126, 1083, 1015, 835, 788cm⁻¹ I-199 ¹HNMR(CDCl₃) δ 2.68(s, 3H), 3.13(s, 3H), 3.55(s, 3H), 3.80(s, 3H), 5.19(s, 2H), 6.88(s, 1H), 7.16(d, J=8.7Hz, 1H), 7.34(d, J=2.1Hz, 1H), 7.36–7.50(m, 6H), 7.81(d, J=8.4Hz, 2H), 7.98(d, J=8.4Hz, 2H) IR(KBr)1698, 1602, 1481, 1351, 1232, 1182, 1079cm⁻¹ I-200 ¹HNMR(CDCl₃) δ 2.42(s, 3H), 2.71(s, 3H), 3.03(s, 3H), 3.21(s, 3H), 3.56(s, 3H), 3.79(s, 3H), 5.17(s, 2H), 6.84(s, 1H), 7.19(d, J=8.4Hz, 1H), 7.22–7.30(m, 3H), 7.37(dd, J=8.4, 2.1Hz, 1H), 7.38(d, J=8.7Hz, 2H), 7.41(d, J=2.1Hz, 1H), 7.41–7.45(m, 1H), 7.68(d, J=8.7Hz, 2H) IR(Nujol)1607, 1519, 1480, 1177, 1151, 1079, 970, 875, 798cm⁻¹ I-201 ¹HNMR(CDCl₃) δ 2.38(s, 3H), 2.67(s, 3H), 3.14(s, 3H), 3.21(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 5.15(s, 2H), 6.84(s, 1H), 7.14(d, J=8.4Hz, 1H), 7.17(brd, J=7.5Hz, 1H), 7.23–7.30(m, 3H), 7.34(dd, J=8.4, 1.8Hz, 1H), 7.38(d, J=8.7Hz, 2H), 7.41(d, J=1.8Hz, 1H), 7.68(d, J=8.7Hz, 2H) IR(Nujol)1606, 1519, 1482, 1180, 1150, 1078, 1011, 979, 876, 790cm⁻¹ I-202 ¹HNMR(CDCl₃) δ 2.30(s, 3H), 2.38(s, 6H), 2.74(s, 3H), 2.94(s, 3H), 3.21(s, 3H), 3.57(s, 3H), 3.79(s, 3H), 5.13(s, 2H), 6.85(s, 1H), 6.91 (brs, 2H), 7.37(d, J=8.7Hz, 2H), 7.40(brs, 2H), 7.41(dd, J=8.4, 1.8Hz, 1H), 7.69(d, J=8.7Hz, 2H) IR(CHCl₃)1610, 1518, 1477, 1370, 1177, 1149, 1082, 970, 873cm⁻¹ I-203 ¹HNMR(CDCl₃) δ 2.34(s, 6H), 2.66(s, 3H), 3.15(s, 3H), 3.21(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 5.12(s, 2H), 6.84(s, 1H), 6.99(brs, 1H), 7.06 (brs, 2H), 7.14(d, J=8.4Hz, 1H), 7.33(dd, J=8.4, 2.1Hz, 1H), 7.38(d, J=8.7Hz, 2H), 7.40(d, J=2.1Hz, 1H), 7.68(d, J=8.7Hz, 2H) IR(Nujol)1607, 1519, 1480, 1178, 1152, 1097, 1014, 969, 876, 824, 797cm⁻¹

TABLE 46 I-204 ¹HNMR(CDCl₃) δ 2.72(s, 3H), 3.16(s, 3H), 3.21(s, 3H), 3.55(s, 3H), 3.78(s, 3H), 3.94(s, 3H), 5.25(s, 2H), 6.84(s, 1H), 7.11(d, J=8.4Hz, 1H), 7.34(dd, J=8.4, 2.1Hz, 1H), 7.38(d, J=8.7Hz, 2H), 7.42(d, J=2.1Hz, 1H), 7.55(d, J=8.4Hz, 2H), 7.68(d, J=8.7Hz, 2H), 8.09(d, J=8.4Hz, 2H) IR(Nujol)1719, 1610, 1519, 1480, 1177, 1151, 1119, 1080, 1016, 969, 875, 798cm⁻¹ I-205 m.p. 153–157° C. ¹HNMR(CDCl₃) δ 2.70(s, 3H), 3.16(s, 3H), 3.21(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 5.13(s, 2H), 6.41(dd, J=3.3, 2.0Hz, 1H), 6.49(d, J=3.3Hz, 1H), 6.84(s, 1H), 7.20(d, J=8.7Hz, 1H), 7.37(dd, J=8.7, 2.1Hz, 1H), 7.38(d, J=8.7Hz, 2H), 7.41(d, J=2.1Hz, 1H), 7.46(d, J=2.0Hz, 1H), 7.68(d, J=8.7Hz, 2H) IR(Nujol)1605, 1518, 1482, 1375, 1361, 1180, 1150, 1079, 1013, 977, 876, 814, 800cm⁻¹ I-206 ¹HNMR(CDCl₃) δ 2.41(s, 3H), 3.46(s, 3H), 3.75(s, 3H), 5.13(s, 2H), 6.45(s, 1H), 6.92(d, J=8.7Hz, 2H), 6.99(dd, J=8.4, 2.1Hz, 1H), 7.07 (d, J=8.4Hz, 1H), 7.09(d, J=2.1Hz, 1H), 7.22–7.34(m, 3H), 7.40(brd, J=7.8Hz, 1H), 7.53(d, J=8.7Hz, 2H) IR(Nujol)3471, 3436, 3339, 1612, 1581, 1523, 1489, 1266, 1245, 1228, 1185, 1110, 1070, 1011, 998, 945, 823, 781cm⁻¹ I-207 ¹HNMR(CDCl₃) δ 2.40(s, 3H), 3.45(s, 3H), 3.75(s, 3H), 5.11(s, 2H), 6.45(s, 1H), 6.91(d, J=8.7Hz, 2H), 6.95(dd, J=8.4, 1.8Hz, 1H), 7.01 (d, J=8.4Hz, 1H), 7.09(d, J=1.8Hz, 1H), 7.19(brd, J=7.5Hz, 1H), 7.22–7.34(m, 3H), 7.53(d, J=8.7Hz, 2H) IR(Nujol)3410, 1611, 1589, 1523, 1489, 1246, 1225, 1114, 1071, 1011, 939, 824, 814, 778cm⁻¹ I-208 m.p. 230–236° C. ¹HNMR(DMSO-d₆) δ 2.25(s, 3H), 2.35(s, 6H), 3.31(s, 3H), 3.65(s, 3H), 5.00(s, 2H), 6.39(s, 1H), 6.69(dd, J=8.4, 1.8Hz, 1H), 6.76(d, J=1.8Hz, 1H), 6.84(d, J=8.7Hz, 1H), 6.90(brs, 2H), 7.06(d, J=8.4Hz, 3H), 7.44(d, J=8.7Hz, 2H) IR(Nujol)3475, 3361, 1609, 1579, 1521, 1260, 1244, 1110, 1071, 1012, 988, 822, 782cm⁻¹ I-209 ¹HNMR(CDCl₃) δ 2.35(s, 6H), 3.45(s, 3H), 3.75(s, 3H), 5.07(s, 2H), 6.45(s, 1H), 6.91(d, J=8.7Hz, 2H), 6.95(dd, J=8.4, 1.8Hz, 1H), 7.01 (brs, 1H), 7.02(d, J=8.4Hz, 1H), 7.06(brs, 2H), 7.08(d, J=1.8Hz, 1H), 7.53(d, J=8.7Hz, 2H) IR(Nujol)3410, 1610, 1588, 1523, 1489, 1248, 1225, 1114, 1071, 1011, 940, 825, 808,cm⁻¹

TABLE 47 I-210 ¹HNMR(CD₃OD) δ 3.37(s, 3H), 3.67(s, 3H), 5.25(s, 2H), 6.43(s, 1H), 6.77(dd, J=8.4, 2.1Hz, 1H), 6.84(d, J=8.7Hz, 2H), 6.89(d, J=2.1Hz, 1H), 6.94(d, J=8.4Hz, 1H), 7.45(d, J=8.7Hz, 2H), 7.60(d, J=8.4Hz, 2H), 8.04(d, J=8.4Hz, 2H) IR(Nujol)3384, 1694, 1612, 1591, 1523, 1488, 1249, 1113, 1071, 1013, 940, 826, 812, 765cm⁻¹ I-211 ¹HNMR(CDCl₃) δ 3.45(s, 3H), 3.74(s, 3H), 5.09(s, 3H), 6.41(dd, J=3.3, 1.8Hz, 1H), 6.45(s, 1H), 6.47(d, J=3.3Hz, 1H), 6.92(d, J=8.7Hz, 2H), 6.97(dd, J=8.4, 2.1Hz, 1H), 7.07(d, J=2.1Hz, 1H), 7.08(d, J=8.4Hz, 1H), 7.48(dd, J=1.8, 1.0Hz, 1H), 7.54(d, J=8.7Hz, 2H) IR(Nujol)3410, 1612, 1589, 1523, 1489, 1248, 1226, 1113, 1071, 1011, 939, 815, 747cm⁻¹ I-212 m.p. 156–158° C. ¹HNMR(CDCl₃) δ 1.06(t, J=7.4Hz, 3H), 1.75(s, 3H), 2.10(q, J=7.4Hz, 2H), 3.46(s, 3H), 3.75(s, 3H), 4.64(d, J=7.0Hz, 2H), 5.52(t, J=7.0Hz, 1H), 6.45(s, 1H), 6.92(d, J=8.6Hz, 2H), 6.96(br.s, 2H), 7.06(br.s, 1H), 7.53(d, J=8.6Hz, 2H) IR(KBr)3392, 2960, 2934, 1610, 1583, 1568, 1523, 1492, 1465, 1406, 1259, 1241, 1224, 1198, 1118, 1071, 824, 812cm⁻¹ I-213 m.p. 175–177° C. ¹HNMR(CDCl₃) δ 1.77(s, 3H), 1.80(s, 6H), 3.46(s, 3H), 3.75(s, 3H), 4.59(s, 2H), 6.45(s, 1H), 6.92(d, J=8.7Hz, 2H), 6.96(br.s, 2H), 7.06 (br.s, 1H), 7.53(d, J=8.7Hz, 2H) IR(KBr)3449, 2929, 1612, 1581, 1523, 1489, 1403, 1262, 1243, 1228, 1113, 1070, 823, 807cm⁻¹ I-214 ¹HNMR(CDCl₃) δ 1.66(tt, J=6.6, 6.6Hz, 2H), 1.74(tt, J=6.6, 6.6Hz, 2H), 2.32(t, J=6.6Hz, 2H), 2.34(t, J=6.6Hz, 2H), 2.71(s, 3H), 3.21 (s, 3H), 3.24(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 4.62(d, J=6.9Hz, 2H), 5.60(m, 1H), 6.84(s, 1H), 7.09(d, J=8.7Hz, 1H), 7.34(dd, J=8.7, 2.1Hz, 1H), 7.37(d, J=8.7Hz, 2H), 7.38(d, J=2.1Hz, 1H), 7.67(d, J=8.7Hz, 2H) IR(KBr)2941, 1610, 1518, 1418, 1365, 1177, 1151, 1079, 847, 818cm⁻¹ I-215 ¹HNMR(CDCl₃) δ 1.57–1.72(m, 4H), 2.05–2.13(m, 4H), 2.70(s, 3H), 3.21(s, 3H), 3.23(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 4.48(s, 2H), 5.86 (s, 1H), 6.84(s, 1H), 7.09(d, J=8.4Hz, 1H), 7.34(dd, J=8.4, 2.1Hz, 1H), 7.38(d, J=8.7Hz, 2H), 7.38(d, J=2.1Hz, 1H), 7.67(d, J=8.7Hz, 2H) IR(KBr)2936, 1610, 1518, 1481, 1365, 1177, 1151, 1079, 818cm⁻¹

TABLE 48 I-216 ¹HNMR(CDCl₃) δ 1.74(d, J=6.6Hz, 3H), 2.54(d, J=2.1Hz, 1H), 2.70(s, 3H), 3.21(s, 3H), 3.24(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 5.00(dd, J=6.6, 2.1Hz, 1H), 6.84(s, 1H), 7.28(d, J=8.7Hz, 1H), 7.36(dd, J=8.7, 2.1Hz, 1H), 7.38(d, J=8.7Hz, 2H), 7.41(d, J=2.1Hz, 1H), 7.68(d, J=8.7Hz, 2H) IR(KBr)3282, 3023, 2940, 1609, 1519, 1481, 1365, 1177, 1151, 1079, 970, 815cm⁻¹ I-217 m.p. 80–85° C. ¹HNMR(CDCl₃) δ 1.62–1.77(m, 4H), 2.25–2.39(m, 4H), 3.46(s, 3H), 3.75(s, 3H), 4.60(d, J=7.0Hz, 2H), 5.63(m, 1H), 6.45(s, 1H), 6.92 (d, J=8.6Hz, 1H), 6.95(br.s, 2H), 7.06(br.s, 1H), 7.68(d, J=8.6Hz, 2H) IR(KBr)3282, 3023, 2940, 1609, 1519, 1481, 1365, 1177, 1151, 1079, 970, 815cm⁻¹ I-218 foam ¹HNMR(CDCl₃) δ 3.45(s, 3H), 3.77(s, 3H), 5.16(s, 2H), 5.69(brs, 1H), 5.86(s, 1H), 6.47(s, 1H), 6.95(dd, J=2.1, 8.4Hz, 1H), 7.04(d, J=8.4Hz, 1H), 7.08(d, J=2.1Hz, 1H), 7.34–7.65(m, 7H), 7.83–7.92(m, 2H) IR(CHCl₃)3530, 3022, 1614, 1588, 1500, 1485, 1463, 1405, 1326, 1290, 1249, 1168, 1130, 1117, 1073, 1011cm⁻¹ I-219 foam ¹HNMR(CDCl₃) δ 1.69(s, 3H), 1.74(s, 3H), 2.51–2.59(m, 2H), 2.74(s, 3H), 3.22(s, 3H), 3.55(s, 3H), 3.79(s, 3H), 4.07(t, J=6.6Hz, 2H), 5.21 (m, 1H), 6.85(s, 1H), 7.08(d, J=8.7Hz, 1H), 7.35(dd, J=2.1, 8.7Hz, 1H), 7.39(d, J=2.1Hz, 1H), 7.55–7.69(m, 2H), 7.81–7.87(m, 2H) IR(CHCl₃)3024, 1609, 1519, 1481, 1467, 1396, 1369, 1321, 1272, 1179, 1122, 1082, 1015cm⁻¹ I-220 m.p. 124–126° C. ¹HNMR(CDCl₃) δ 1.69(s, 3H), 1.75(s, 3H), 2.50–2.57(m, 2H), 3.46(s, 3H), 3.76(s, 3H), 4.07(t, J=6.9Hz, 2H), 5.22(m, 1H), 5.69(brs, 1H), 5.84(s, 1H), 6.46(s, 1H), 6.93–7.05(m, 3H), 7.55–7.65(m, 2H), 7.82–7.91(m, 2H). IR(KBr)3406, 2935, 1587, 1519, 1501, 1488, 1459, 1359, 1323, 1304, 1291, 1274, 1223, 1170, 1126, 1113, 1075, 1018cm⁻¹

TABLE 49 I-221 m.p. 187–189° C. ¹HNMR(CDCl₃) δ 2.33(s, 3H), 2.69(s, 3H), 3.21(s, 3H), 3.24(s, 3H), 3.55(s, 3H), 3.77(s, 3H), 4.17(s, 2H), 6.84(s, 1H), 7.12&7.25(ABq, J=8.7Hz, 4H), 7.31(dd, J=8.1Hz, J=1.5Hz, 1H), 7.38&7.67(ABq, J=8.7Hz, 4H), 7.42(d, J=8.1Hz, 1H), 7.46(d, J=1.5Hz, 1H) IR(KBr)1512, 1474, 1417, 1391, 1356, 1343, 1177, 1149, 1082, 1054, 1013, 976, 961, 939, 867, 854, 844, 820, 812, 799, 523cm⁻¹ I-222 m.p. 107–112° C. ¹HNMR(CDCl₃) δ 2.73(s, 3H), 3.22(s, 3H), 3.28(s, 3H), 3.55(s, 3H), 3.77(s, 3H), 4.34(s, 2H), 6.84(s, 1H), 7.19(m, 1H), 7.30(dd, J=8.1Hz, J=1.8Hz, 1H), 7.34–7.41(m, 3H), 7.46(d, J=1.8Hz, 1H), 7.49(d, J=8.1Hz, 1H), 7.62–7.69(m, 3H), 8.55(m, 1H) IR(KBr)1474, 1389, 1364, 1179, 1151, 1081, 937, 873, 813, 797, 523cm⁻¹ I-223 m.p. 212–214° C. ¹HNMR(CDCl₃+CD₃OD) δ 3.45(s, 3H), 3.74(s, 3H), 4.13(s, 2H), 6.45(s, 1H), 6.90–6.96(m, 3H), 7.12(d, J=1.8Hz, 1H), 7.18–7.26(m, 2H), 7.48–7.54(m, 3H), 7.68(m, 1H), 8.63(m, 1H) IR(KBr)3504, 3272, 1612, 1596, 1574, 1521, 1492, 1463, 1436, 1405, 1362, 1310, 1265, 1222, 1172, 1116, 1083, 1052, 1017, 828cm⁻¹ I-224 m.p. 199–200° C. ¹HNMR(CDCl₃) δ 1.46(d, J=0.9Hz, 3H), 1.77(s, 3H), 3.44(s, 3H), 3.74(s, 3H), 3.90(m, 2H), 5.25(m, 1H), 6.04(brs, 1H), 6.45(s, 1H), 6.93 &7.53(ABq, J=8.7Hz, 4H), 7.00(m, 2H), 7.05(m, 1H) IR(KBr)3404, 2999, 2932, 1612, 1595, 1522, 1483, 1454, 1432, 1401, 1376, 1357, 1271, 1223, 11 19, 1080, 1055, 1015, 974, 938, 829, 817cm⁻¹ I-225 m.p. 181–183° C. ¹HNMR(CDCl₃) δ 1.37(s, 9H), 3.45(s, 3H), 3.75(s, 3H), 4.93(brs, 1H), 6.00(s, 1H), 6.46(s, 1H), 6.93&7.54(ABq, J=8.7Hz, 4H), 6.99(s, 1H), 7.01(dd, J=8.4Hz, J=1.5Hz, 1H), 7.16(d, J=1.5Hz, 1H), 7.49(d, J=8.4Hz, 1H) IR(KBr)3495, 3412, 2959, 2931, 1610, 1568, 1552, 1521, 1499, 1477, 1459, 1400, 1364, 1319, 1270, 1227, 1192, 1161, 1116, 1102, 1090, 1052, 1019, 942, 833, 817, 588cm⁻¹

TABLE 50 I-226 m.p. 154–156° C. ¹HNMR(CDCl₃) δ 2.33(s, 3H), 3.45(s, 3H), 3.75(s, 3H), 3.90(s, 2H), 4.68(s, 1H), 5.97(s, 1H), 6.45(s, 1H), 6.60(s, 1H), 6.90–6.98(m, 3H), 7.10(s, 5H), 7.41(d, J=8.1Hz, 1H), 7.53(m, 2H) IR(KBr)3462, 3368, 1611, 1550, 1521, 1499, 1472, 1455, 1437, 1401, 1362, 1321, 1293, 1267, 1229, 1187, 1174, 1164, 1118, 1077, 1050, 1011, 821cm⁻¹ I-227 m.p. 172–174° C. ¹HNMR(CDCl₃) δ 1.38(d, J=1.2Hz, 3H), 1.76(s, 3H), 3.44(s, 3H), 3.75(s, 3H), 3.87(d, J=7.8Hz, 2H), 5.08(brs, 1H), 5.26(m, 1H), 6.08(s, 1H), 6.45(s, 1H), 6.94&7.53(ABq, J=8.7Hz, 4H), 7.11–7.14(m, 2H), 7.62(d, J=8.7Hz, 1H), 8.87(s, 1H) IR(KBr)3412, 1613, 1520, 1478, 1458, 1443, 1404, 1360, 1346, 1290, 1270, 1224, 1200, 1171, 1119, 1078, 1054, 945cm⁻¹ I-228 m.p. 173–175° C. ¹HNMR(CDCl₃) δ 1.69(s, 3H), 1.74(s, 3H), 2.10(s, 3H), 2.50–2.61(m, 2H), 3.20(s, 3H), 3.21(s, 3H), 3.37(s, 3H), 3.71(s, 3H), 4.08(t, J=6.8Hz, 2H), 5.21–5.25(m, 1H), 6.73(s, 1H), 7.03–7.18(m, 2H), 7.23–7.25(m, 2H), 7.37(d, J=8.6Hz, 2H), 7.69(d, J=8.8Hz, 2H) IR(KBr)3600–3200(br), 3100–2800(br), 1610, 1527, 1523, 1477, 1432, 1365, 1240, 1172, 1160, 955, 923cm⁻¹ I-229 m.p. 148–150° C. ¹HNMR(CDCl₃) δ 1.70(s, 3H), 1.77(s, 3H), 2.09(s, 3H), 2.48–2.62(m, 2H), 3.38(s, 3H), 3.73(s, 3H), 4.09(t, J=7.0Hz, 2H), 4.84(br, 1H), 5.19–5.22(m, 1H), 5.70(s, 1H), 6.71–6.96(m, 5H), 7.55(d, J=8.2Hz, 2H) IR(KBr)3700–3200(br), 3100–2800(br), 1612, 1584, 1560, 1448, 1428, 1390, 1339, 1315, 1284, 1246, 1173, 1160, 1123, 1018, 999cm⁻¹ I-230 m.p. 194–195° C. ¹HNMR(CDCl₃) δ 2.10(s, 3H), 2.39(s, 3H), 3.10(s, 3H), 3.21(s, 3H), 3.36(s, 3H), 3.71(s, 3H), 5.13(s, 2H), 6.73(s, 1H), 7.14–7.18(m, 8H), 7.69(d, J=9.0Hz, 2H) IR(KBr)3600–3200(br), 3100–2800(br), 1516, 1475, 1360, 1332, 1292, 1266, 1228, 1199, 1174, 1151, 1119, 1098, 1084, 1005, 968cm⁻¹

TABLE 51 I-231 m.p. 178–180° C. ¹HNMR(CDCl₃ ) δ 2.09(s, 3H), 2.40(s, 3H), 3.37(s, 3H), 3.72(s, 3H), 4.97(brs, 1H), 5.10(s, 2H), 5.67(br, 1H), 6.70–6.75(m, 2H), 6.86–7.03 (m, 3H), 7.22–7.26(m, 2H), 7.32–7.34(m, 2H), 7.54(d, J=8.2Hz, 2H) IR(KBr)3600–3200(br), 3100–2800(br), 1611, 1519, 1479, 1463, 1388, 1339, 1314, 1286, 1258, 1246, 1225, 1128, 1098, 1077, 1007cm ⁻¹ I-232 m.p. 177–179° C. ¹HNMR(CDCl₃) δ 2.54(s, 3H), 2.69(s, 3H), 3.13(s, 3H), 3.54(s, 3H), 3.77(s, 3H), 5.19(s, 2H), 6.85(s, 1H), 7.15(d, J=8.4Hz, 2H), 7.30–7.49 (m, 9H), 7.53–7.59(m, 2H) IR(CHCl₃)1516, 1476, 1368, 1266, 1176, 1118, 1077, 1080, 1013, 970, 876, 820cm⁻¹ I-233 amorphouspowder ¹HNMR(CDCl₃) δ 2.54(s, 3H), 3.46(s, 3H), 3.75(s, 3H), 5.15(s, 2H), 5.67(brs, 1H), 5.90(s, 1H), 6.46(s, 1H), 6.95(d.d, J=1.8&8.1Hz, 1H), 7.02(d, J=8.1Hz, 1H), 7.09(d, J=1.8Hz, 1H), 7.31–7.49(m, 7H), 7.55–7.62(m, 2H) IR(CHCl₃)3526, 1517, 1483, 1414, 1389, 1289, 1246, 1192, 1114, 1070, 1010, 937, 818cm⁻¹ I-234 ¹HNMR(CDCl₃) δ 1.76(s, 3H), 1.81(s, 3H), 2.73(s, 3H), 3.24(s, 3H), 3.53(s, 3H), 3.79(s, 3H), 3.96(s, 3H), 4.64(d, J=6.9Hz, 2H), 5.49(t, J=6.9Hz, 1H), 6.87(s, 1H), 7.09(d, J=8.4Hz, 1H), 7.35(d.d, J=8.4&2.1Hz, 1H), 7.39(d, J=2.1Hz, 1H), 7.71(d, J=8.4Hz, 2H), 8.13(d, J=8.4Hz, 2H) I-235 ¹HNMR(CDCl₃) δ 2.69(s, 3H), 3.14(s, 3H), 3.55(s, 3H), 3.80(s, 3H), 5.20(s, 2H), 6.89(s, 1H), 7.16(d, J=9.0Hz, 1H), 7.34(d, J=2.1Hz, 1H), 7.36–7.51(m, 6H), 7.75(d, J=8.4Hz, 2H), 8.23(d, J=8.4Hz, 2H) IR(KBr)3427, 1724, 1685, 1606, 1509, 1481, 1369, 1272, 1235, 1179, 1120, 1084, 1017cm⁻¹ I-236 ¹HNMR(CDCl₃) δ 3.46(s, 3H), 3.77(s, 3H), 5.16(s, 3H), 6.50(s, 3H), 6.96(dd, J=8.4&2.1Hz, 1H), 7.03(d, J=8.4Hz, 1H), 7.09(d, J=2.1Hz, 1H), 7.34–7.50(m, 5H), 7.75(d, J=8.1Hz, 2H), 8.17(d, J=8.1Hz, 2H)

TABLE 52 I-237 ¹HNMR(CDCl₃) δ 3.44(s, 3H), 3.76(s, 3H), 3.96(s, 3H), 5.16(s, 2H), 5.69(s, 1H), 5.89(s, 1H), 6.49(s, 1H), 6.96(d.d, J=8..4&2.1Hz, 1H), 7.03(d, J=8.4Hz, 1H), 7.09(d, J=2.1Hz, 1H), 7.32–7.50(m, 5H), 7.73(d, J=8.4Hz, 2H), 8.13(d, J=8.4Hz, 2H) IR(KBr)3497, 3443, 1708, 1608, 1585, 1487, 1460, 1443, 1395, 1281, 1113, 1068, 1008cm⁻¹ I-238 ¹HNMR(CDCl₃) δ 2.69(s, 3H), 3.13(s, 3H), 3.53(s, 3H), 3.79(s, 3H), 3.96(s, 3H), 5.19(s, 2H), 6.87(s, 1H), 7.15(d, J=9.0Hz, 1H), 7.31–7.50(m, 7H), 7.71(d, J=8.4Hz, 2H), 8.13(d, J=8.4Hz, 2H) IR(KBr)1719, 1608, 1481, 1366, 1278, 1118, 1080, 1017cm⁻¹ I-239 ¹HNMR(CDCl₃) δ 2.38(s, 3H), 2.68(s, 3H), 3.12(s, 3H), 3.53(s, 3H), 3.79(s, 3H), 3.96(s, 3H), 5.14(s, 2H), 6.87(s, 1H), 7.15(d, J=8.7Hz, 1H), 7.21(d, J=8.4Hz, 2H), 7.34(d, J=8.4Hz, 2H), 7.36(d, J=8.7Hz, 1H), 7.40(d, J=2.1Hz, 1H), 7.71(d, J=8.7Hz, 2H), 8.13(d, J=8.4Hz, 2H) IR(KBr)1718, 1607, 1519, 1481, 1355, 1280, 1232, 1182, 1121, 1079, 1018cm⁻¹ I-240 ¹HNMR(CDCl₃) δ 2.70(s, 3H), 3.03(s, 3H), 3.12(s, 3H), 3.55(s, 3H), 3.77(s, 3H), 5.18(s, 2H), 6.78–6.89(broad, 1H), 6.86(s, 1H), 7.14(d, J=8.4Hz, 1H), 7.31–7.49(m, 8H), 7.55(d, J=8.4Hz, 2H) IR(KBr)1604, 1526, 1483, 1395, 1374, 1360, 1292, 1231, 1177, 1119, 1078, 1014cm⁻¹ I-241 ¹HNMR(CDCl₃) δ 2.37(s, 3H), 2.69(s, 3H), 3.05(s, 3H), 3.12(s, 3H), 3.55(s, 3H), 3.77(s, 3H), 5.14(s, 2H), 6.85(s, 1H), 6.81–6.91(broad, 2H), 7.14(d, J=8.4Hz, 1H), 7.21(d, J=8.1Hz, 1H), 7.34(d, J=8.1Hz, 2H), 7.40(d, J=2.1Hz, 1H), 7.56(d, J=8.4Hz, 2H) IR(KBr)1605, 1529, 1484, 1396, 1356, 1275, 1233, 1178, 1121, 1078, 1016cm⁻¹ I-242 ¹HNMR(CDCl₃) δ 1.76(s, 3H), 1.81(s, 3H), 2.73(s, 3H), 3.03(s, 6H), 3.22(s, 3H), 3.55(s, 3H), 3.77(s, 3H), 4.63(d, J=6.6Hz, 2H), 5.49(t, J=6.6Hz, 1H), 6.75–6.91(broad, 2H), 6.86(s, 1H), 7.08(d, J=8.7Hz, 1H), 7.34(d.d, J=8.7&2.1Hz, 1H), 7.39(d, J=2.1Hz, 1H), 7.55(d, J=8.7Hz, 1H)IR(KBr)1609, 1529, 1482, 1363, 1235, 1178, 1117, 1078, 1013cm⁻¹ I-243 IR(KBr)3409, 1608, 1509, 1464, 1367, 1230, 1175, 1149, 1079, 1018cm⁻¹

TABLE 53 I-244 ¹HNMR(CDCl₃) δ 1.72(s, 3H), 1.76(s, 3H), 2.55(m, 2H), 3.22(s, 3H)3.45(s, 3H), 3.72(s, 3H), 4.07(d, J=6.6Hz, 2H), 4.46(d, J=10.5Hz, 1H), 4.51(d, J=10.5Hz, 1H), 4.66(d, J=10.5Hz, 1H), 4.75(d, J=10.5Hz, 1H), 5.24(brs, 1H), 6.84(s, 1H), 6.95(d, J=8.7Hz, 1H), 7.02(s, 1H), 7.21(d, J=8.7Hz, 1H), 7.39(d, J=9.0Hz, 2H)7.71(d, J=9.0Hz, 2H) IR(KBr)3307, 1609, 1509, 1465, 1364, 1235, 1180, 1152, 1082, 1021cm⁻¹ I-245 m.p. 182–184° C. ¹HNMR(CDCl₃) δ 2.42(s, 3H), 2.70(s, 3H), 3.13(s, 3H), 3.53(s, 3H), 3.77(s, 3H), 5.19(s, 2H)6.86(s, 1H), 7.13–7.53(m, 12H) IR(KBr)3434, 3030, 2937, 1605, 1522, 1483, 1366, 1274, 1235, 1176, 1119, 1086, 1011cm⁻¹ I-246 ¹HNMR(CDCl₃) δ 2.58(s, 3H), 3.21(s, 3H), 3.55(s, 3H), 3.77(s, 3H)3.91(s, 3H), 5.26(m, 2H), 6.84(s, 1H), 7.12(d, J=9.0Hz, 1H), 7.27–7.54 (m, 8H), 7.60(d, J=8.7Hz, 2H), 7.90(d, J=2.1Hz, 1H) IR(KBr)1728, 1699, 1605, 1513, 1480, 1362, 1239, 1175, 1150, 1083, 1017cm⁻¹ I-247 IR(KBr)1729, 1607, 1512, 1479, 1366, 1234, 1177, 1151, 1079, 1015cm⁻¹ I-248 ¹H NMR(CDCl₃) δ 1.75 (s, 3H), 1.79 (s, 3H), 2.57 (s, 3H), 3.21 (s, 3H), 3.56 (s, 3H), 3.78 (s, 3H), 3.89(s, 3H), 4.63 (d, J=6.6Hz, 2H), 5.49–5.58 (m, 1H), 6.85 (s, 1H), 6.93–7.00 (m, 3H), 7.38 (d, J=8.7Hz, 2H), 7.70 (d, J=8.7Hz, 2H) IR(KBr)1603, 1518, 1482, 1365, 1239, 1176, 1150, 1078cm⁻¹ I-249 foam ¹HNMR(CDCl₃) δ 2.30(br, 1H), 2.76–2.82(m, 2H), 3.64–3.68(m, 2H), 3.87(s, 1H), 5.14(s, 2H), 5.70(s, 1H), 6.70(dd, J=2.1, 8.4Hz, 1H), 6.78 (s, 1H), 6.84(d, J=1.8Hz, 1H), 6.97–7.01(m, 3H), 7.37–7.49(m, 5H), 7.56–7.61(m, 2H) IR(KBr)3600–2800(br), 1608, 1583, 1517, 1464, 1387, 1287, 1247, 1225, 1178, 1082, 1015cm⁻¹ I-250 m.p. 104–105° C. ¹HNMR(CDCl₃) δ 0.76(t, J=7.5Hz, 3H), 1.44–1.54(m, 2H), 3.61(s, 3H), 3.71(t, J=6.6Hz, 2H), 3.74(s, 3H), 3.87(s, 3H)5.16(s, 2H), 5.63 (s, 1H), 6.66(s, 1H), 6.90(dd, J=2.1, 8.4Hz, 1H), 6.96–7.01(m, 4H), 7.04(d, J=1.8Hz, 1H), 7.37–7.48(m, 5H), 7.51–7.56(m, 2H) IR(KBr)3600–2800(br), 1608, 1593, 1518, 1474, 1462, 1379, 1294, 1251, 1226, 1183, 1109, 1078, 1040, 1008cm⁻¹

TABLE 54 I-251 m.p. 103–105° C. ¹HNMR(CDCl₃) δ 0.78(t, J=7.2Hz, 3H), 1.15–1.27(m, 2H), 1.43–1.51(m, 2H), 3.61(s, 3H), 3.73–3.77(m, 2H), 3.74(s, 3H), 3.87(s, 3H), 5.16 (s, 2H), 5.63(s, 1H), 6.65(s, 1H), 6.90(dd, J=2.1, 8.1Hz, 1H), 6.96–7.01(m, 3H), 7.04(d, J=2.1Hz, 1H), 7.37–7.48(m, 5H), 7.51–7.56(m, 2H) IR(KBr)3600–2800(br), 1607, 1518, 1467, 1375, 1288, 1251, 1179, 1113, 1084, 1020, 1008cm⁻¹ I-252 m.p. 111.5–112.5° C. ¹HNMR(CDCl₃) δ 0.78(t, J=7.5Hz, 3H), 1.15–1.27(m, 2H), 1.41–1.50(m, 2H), 3.10(s, 3H), 3.61(s, 3H), 3.73–3.78(m, 2H), 3.74(s, 6H), 5.18 (s, 2H), 6.66(s, 1H), 6.96–7.01(m, 2H), 7.10(d, J=8.7Hz, 1H), 7.26–7.55(m, 9H) IR(KBr)3600–2800(br), 1609, 1518, 1464, 1440, 1375, 1355, 1289, 1269, 1249, 1181, 1170, 1107, 1080, 1019cm⁻¹ I-253 ¹HNMR(CDCl₃) δ 1.76(s, 3H), 1.82(s, 3H), 3.45(s, 3H), 3.76(s, 3H), 4.62(d, J=8.4Hz, 2H), 5.54(t, J=8.4Hz, 1H), 6.49(s, 1H), 6.91–6.99 (m, 2H), 7.05(d, J=1.5Hz), 7.74(d, J=8.7Hz, 2H), 8.15(d, J=8.7Hz, 2H) IR(KBr)3474, 1687, 1607, 1509, 1417, 1397, 1316, 1287, 1240, 1109 1071, 1006cm⁻¹ I-254 ¹HNMR(CDCl₃) δ 2.39(s, 3H), 3.45(s, 3H), 3.76(s, 3H), 5.11(s, 2H), 6.49(s, 1H), 6.94(dd, J=8.4&1.8Hz, 1H), 7.04(d, J=8.4Hz, 1H), 7.06 (d, J=1.8Hz), 7.19–7.38(m, 4H), 7.73(d, J=8.4Hz, 2H), 8.14(d, J=8.4Hz, 2H) IR(KBr)3549, 3466, 1668, 1603, 1518, 1489, 1465, 1449, 1421, 1397, 1372, 1288, 1236, 1186, 1117, 1074, 1017cm⁻¹ I-255 ¹HNMR(CDCl₃) δ 1.76(s, 3H), 1.82(s, 3H), 3.02(s, 6H), 3.48(s, 3H), 3.74(s, 3H), 4.61(d, J=7.2Hz, 2H), 5.53(t, J=7.2Hz, 1H), 5.66(s, 1H), 5.92(s, 1H), 6.47(s, 1H), 6.81(broad, 2H), 6.95(s, 2H), 7.06(s, 1H), 7.56(d, J=8.7Hz, 2H) IR(KBr)3535, 3494, 3452, 1606, 1526, 1487, 1406, 1357, 1288, 1242, 1195, 1112cm⁻¹ I-256 ¹HNMR(CDCl₃) δ 2.39(s, 3H), 3.02(s, 6H), 3.48(s, 3H)3.74(s, 3H)5.10(s, 2H), 5.66(s, 1H), 5.93(s, 1H), 6.47(s, 1H), 6.82(d, J=8.4Hz, 2H), 6.96(dd, J=8.1&1.8Hz, 1H), 7.02(d, J=8.1Hz, 1H), 7.08(d, J=1.8Hz, 1H), 7.23(d, J=7.8Hz, 2H), 7.34(d, J=7.8Hz, 2H), 7.56(d, J=8.4Hz, 2H) IR(KBr)3536, 3379, 1610, 1586, 1528, 1489, 1460, 1443, 1361, 1288, 1250, 1225, 1195, 1117, 1072, 1008cm⁻¹

TABLE 55 I-257 ¹HNMR(CDCl₃) δ 1.71(s, 3H), 1.76(s, 3H), 2.49–2.60(m, 2H), 3.44(s, 3H), 3.70(s, 3H), 4.06(t, J=6.3Hz, 2H), 4.48(d, J=6.0Hz, 2H), 4.71 (d, J=8.7Hz, 2H), 5.23(t, J=8.7Hz, 1H), 5.37(broads, 1H), 6.84(s, 1H), 6.91–6.97(m, 1H), 6.92(d, J=8.4Hz, 2H), 7.18–7.23(m, 2H), 7.52 (d, J=8.7Hz, 2H) IR(KBr)3398, 1612, 1518, 1465, 1389, 1232, 1174, 1131, 1101, 1081, 1023cm⁻¹ I-258 ¹HNMR(CDCl₃) δ: 3.21(s, 3H), 3.41(s, 3H), 3.63(s, 3H), 3.77(s, 3H), 4.76(s, 2H), 5.15(s, 2H), 6.94(s, 1H), 6.99(d, J=8.7Hz, 1H), 7.23–7.49 (m, 9H), 7.71(d, J=8.7Hz, 2H) IR(KBr)3497, 1738, 1721, 1607, 1509, 1469, 1362, 1242, 1152, 1056, 1017cm⁻¹ I-259 foam ¹HNMR(CDCl₃) δ 2.35(s, 6H), 2.73(s, 3H), 2.79(t, J=5.7Hz, 2H), 3.21(s, 3H), 3.31(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 4.19(t, J=5.7Hz, 2H), 6.84(s, 1H), 7.09(d, J=8.4Hz, 1H), 7.34–7.41(m, 4H), 7.66–7.71(m, 2H) IR(KBr)3600–2700(br), 1519, 1481, 1365, 1273, 1200, 1177, 1151, 1120, 1079, 1015cm⁻¹ I-260 foam ¹HNMR(CDCl₃ + CD₃OD) δ 2.71(t, J=5.1Hz, 2H), 3.46(s, 6H), 3.73(s, 6H), 4.11(t, J=5.1Hz, 2H), 6.44(s, 1H), 6.87–6.99(m, 4H), 7.04(d, J=2.1Hz, 1H), 7.49–7.53(m, 2H) IR(KBr)3600–2200(br), 1607, 1583, 1519, 1475, 1407, 1390, 1275, 1252, 1226, 1114, 1062cm⁻¹ I-261 m.p. 85–87° C. ¹HNMR(CDCl₃) δ 3.49(s, 3H), 3.75(s, 3H), 5.15(s, 2H), 5.23(brs, 1H), 5.68(brs, 1H), 5.89(s, 1H), 6.43(s, 1H), 6.95(dd, J=8.3, 2.1Hz, 1H), 7.03(d, J=8.3Hz, 1H), 7.08(d, J=2.1Hz, 1H), 7.08(t, J=8.7Hz, 1H), 7.33(ddd, J=8.7, 2.1, 1.2Hz 1H), 7.37–7.47(m, 6H) IR(KBr)3410, 1525, 1488, 1284, 1248, 1102, 1010, 759, 704cm⁻¹

TABLE 56 I-262 m.p. 138–140° C. ¹HNMR(CDCl₃) δ 1.77(s, 3H), 1.82, (s, 3H), 3.21(s, 3H), 3.22(s, 3H), 3.48(s, 3H), 3.78(s, 3H), 4.64(d, J=6.5Hz, 2H), 5.51(t, J=6.5Hz, 1H), 7.05(d, J=8.5Hz, 1H), 7.08(s, 1H), 7.14(dd, J=8.5, 2.2Hz, 1H), 7.34(d, J=2.2Hz, 1H), 7.40(d, J=8.7Hz, 2H), 7.69(d, J=8.7Hz, 2H), 10.00 (s, 1H) IR(KBr)1693, 1514, 1470, 1361, 1348, 1275, 1239, 1175, 1151, 979, 969, 867, 845, 815cm⁻¹ I-263 foam ¹HNMR(DMSO-d₆) δ 1.74(s, 3H), 1.78(s, 3H), 3.32(s, 3H), 3.44(s, 3H), 3.76(s, 3H), 4.66(d, J=6.6Hz, 2H), 5.49(t, J=6.6Hz, 1H), 7.11(s, 1H), 7.23–7.25(m, 3H), 7.48(d, J=8.6Hz, 2H), 7.77(d, J=8.6Hz, 2H), 13.1(brs, 1H) IR(KBr)3431, 1737, 1518, 1471, 1177, 1151, 972, 864, 849cm⁻¹ I-264 m.p. 153.5–155.5° C. ¹HNMR(CDCl₃) δ 2.58(s, 3H), 3.52(s, 3H), 3.77(s, 3H), 5.21(s, 2H), 6.83(s, 1H), 7.04–7.24(m, 5H), 7.30–7.49(m, 5H), 7.56–7.65(m, 2H) IR(CHCl₃)1607, 1520, 1481, 1412, 1368, 1298, 1267, 1131, 1080, 1012, 960, 942, 907, 869, 836, 812cm⁻¹ I-265 dp > 116° C. ¹HNMR(CDCl₃ + CD₃OD) δ 2.69(s, 3H), 3.15(s, 3H), 3.16(s, 3H), 3.57(s, 3H), 3.80(s, 3H), 5.21(s, 2H), 6.88(s, 1H), 7.19(d, J=8.4Hz, 1H), 7.34–7.51(m, 7H), 7.83–7.90(m, 2H), 8.01–8.07(m, 5H) IR(KBr)3434, 3028, 2934, 1596, 1519, 1460, 1365, 1308, 1276, 1173, 1148, 1119, 1108, 1012, 946, 841, 819cm⁻¹ I-266 m.p. 136–138° C. ¹HNMR(CDCl₃) δ 3.43(s, 3H), 3.75(s, 3H), 5.19(s, 2H), 5.98(s, 1H), 6.44(s, 1H), 7.04–7.52(m, 10H), 7.57–7.65(m, 5H) IR(CHCl₃)3496, 1612, 1521, 1488, 1454, 1412, 1391, 1313, 1267, 1157, 1113, 1069, 1010, 934, 825cm⁻¹

TABLE 57 I-267 foam ¹HNMR(CDCl₃) δ 2.38(s, 3H), 3.10(s, 3H), 3.21(s, 3H), 3.41(s, 3H), 3.67(s, 3H), 3.77(s, 3H), 5.11(s, 2H), 6.93(s, 1H), 7.09(d, J=8.6Hz, 1H), 7.21(d, J=8.2Hz, 2H), 7.27(d, J=2.1Hz, 1H), 7.35(d, J=8.2Hz, 2H), 7.38(d, J=8.9Hz, 2H), 7.70(d, J=8.9Hz, 2H) IR(KBr)1733, 1518, 1471, 1367, 1297, 1177, 1151, 1118, 1059, 971, 862, 815cm⁻¹ I-268 amorphous ¹HNMR(DMSO-d₆) δ 1.64(s, 3H), 1.70(s, 3H), 2.44(q, J=7.2Hz, 2H), 3.30(s, 3H), 3.70(s, 3H), 3.93(t, J=7.2Hz, 2H), 5.26(t, J=7.2Hz, 1H), 6.64(dd, J=8.6, 2.1Hz, 1H), 6.74(d, J=2.1Hz, 1H), 6.87(d, J=8.9Hz, 2H), 6.87(d, J=8.6Hz, 1H), 6.96(s, 1H), 7.48(d, J=8.9Hz, 2H), 8.84 (s, 1H), 9.59(s, 1H), 12.8(brs, 1H) IR(CHCl₃)3594, 3540, 1743, 1707, 1520, 1470, 1260, 1058cm⁻¹ I-269 m.p. 206–208° C.(dec.) ¹HNMR(DMSO-d₆) δ 2.32(s, 3H), 3.32(s, 3H), 3.66(s, 3H), 5.05(s, 2H), 6.66(dd, J=8.2, 2.1Hz, 1H), 6.79(d, J=2.1Hz, 1H), 6.83(s, 1H), 6.84 (d, J=8.6Hz, 2H), 6.89(d, J=8.2Hz, 1H), 7.20(d, J=8.0Hz, 2H), 7.38(d, J=8.0Hz, 2H), 7.45(d, J=8.6Hz, 2H), 8.91(s, 1H), 9.68(s, 1H), 12.7(brs, 1H) IR(KBr)3413, 1710, 1612, 1591, 1520, 1471, 1377, 1227, 1083, 1059, 1013, 837, 809cm⁻¹ I-270 foam ¹HNMR(CDCl₃) δ 2.42(s, 3H), 3.45(s, 3H), 3.75(s, 3H), 5.15(s, 2H), 5.68(s, 1H), 5.93(s, 1H), 6.47(s, 1H), 6.96(dd, J=1.8, 8.1Hz, 1H), 7.03 (d, J=1.8Hz, 1H), 7.25–7.28(m, 2H), 7.35–7.48(m, 5H), 7.52–7.56(m, 2H) IR(CHCl₃)3535, 3014, 1616, 1588, 1559, 1523, 1513, 1490, 1463, 1455, 1417, 1396, 1317, 1290, 1247, 1194, 1115, 1072, 1012cm⁻¹ I-271 m.p. 143–145° C. ¹HNMR(CDCl₃) δ 2.70(s, 3H), 3.12(s, 3H), 3.54(s, 3H), 3.73(s, 3H), 3.84(s, 3H), 5.18(s, 2H), 6.83(s, 1H), 7.00–7.07(m, 2H), 7.14(d, J=8.4Hz, 1H), 7.33–7.49(m, 9H) IR(KBr)3434, 2940, 1609, 1520, 1482, 1396, 1369, 1293, 1283, 1243, 1178, 1114, 1080, 1021, 1009cm⁻¹

TABLE 58 I-272 foam ¹HNMR(CDCl₃) δ 3.45(s, 3H), 3.71(s, 3H), 3.86(s, 3H), 5.15(s, 2H), 5.67(s, 1H), 5.84(s, 1H), 6.42(s, 1H), 6.98(dd, J=1.8, 8.4Hz, 1H), 7.01–7.07(m, 2H), 7.11(d, J=1.8Hz, 1H), 7.35–7.45(m, 8H) IR(CHCl₃)3534, 3024, 1617, 1587, 1517, 1503, 1483, 1462, 1409, 1290, 1247, 1226, 1215, 1122, 1104, 1072, 1013cm⁻¹ I-273 m.p. 155–156° C. ¹HNMR(CDCl₃) δ 1.76(s, 3H), 1.81(s, 3H), 2.42(s, 3H), 2.73(s, 3H), 3.23(s, 3H), 3.53(s, 3H), 3.77(s, 3H), 4.63(d, J=6.6Hz, 2H), 5.49(m, 1H), 6.86(s, 1H), 7.09(d, J=8.4Hz, 1H), 7.25–7.53(m, 6H) IR(KBr)3434, 2935, 1605, 1522, 1465, 1388, 1365, 1292, 1273, 1176, 1119, 1084, 1011cm⁻¹ I-274 m.p. 138–140° C. ¹HNMR(CDCl₃) δ 1.76(s, 3H), 1.81(s, 3H), 2.73(s, 3H), 3.22(s, 3H), 3.54(s, 3H), 3.73(s, 3H), 3.84(s, 3H), 4.63(d, J=6.9Hz, 2H), 5.50(m, 1H), 6.83(s, 1H), 7.01–7.04(m, 2H), 7.08(d, J=8.4Hz, 1H), 7.26(d, J=0.6Hz, 1H), 7.34–7.43(m, 3H) IR(KBr)3433, 2937, 1608, 1519, 1480, 1400, 1368, 1292, 1271, 1244, 1179, 1112, 1081, 1011cm⁻¹ I-275 m.p. 95–97° C. ¹HNMR(CDCl₃) δ 1.76(s, 3H), 1.82(s, 3H), 2.42(s, 3H), 3.45(s, 3H), 3.74(s, 3H), 4.61(d, J=6.6Hz, 2H), 5.52(m, 1H), 5.69(s, 1H), 6.47(s, 1H), 6.95–7.07(m, 3H), 7.25–7.28(m, 2H), 7.52–7.55(m, 2H) IR(KBr)3479, 2935, 1613, 1585, 1523, 1509, 1490, 1458, 1415, 1395, 1362, 1315, 1249, 1196, 1112, 1070, 1005cm⁻¹ I-276 m.p. 155–158° C. ¹HNMR(CDCl₃) δ 1.76(d, J=0.9Hz, 3H), 1.82(d, J=0.9Hz, 3H), 3.45(s, 3H), 3.86(s, 3H), 4.61(d, J=6.9Hz, 2H), 5.35(m, 1H), 5.68(s, 1H), 5.82(s, 1H), 6.42(s, 1H), 6.96–7.09(m, 4H), 7.35–7.41(m, 2H) IR(KBr)3428, 3005, 2952, 1613, 1583, 1517, 1505, 1487, 1464, 1451, 1411, 1387, 1359, 1317, 1289, 1245, 1140, 1101, 1070, 1013cm⁻¹

TABLE 59 I-277 m.p. 173–175° C. ¹HNMR(CDCl₃) δ 1.68(s, 3H), 1.74(s, 3H), 2.42(s, 3H), 2.51–2.60(m, 2H), 2.75(s, 3H), 3.21(s, 3H), 3.53(s, 3H), 3.76(s, 3H), 4.07(t, J=6.9Hz, 2H), 5.21(m, 1H), 6.86(s, 1H), 7.06(d, J=8.7Hz, 1H), 7.25–7.28(m, 2H), 7.35(dd, J=2.1, 8.7Hz, 1H), 7.40(d, J=2.1Hz, 1H), 7.50–7.53 (m, 2H) IR(KBr)3434, 2934, 1606, 1523, 1482, 1388, 1369, 1277, 1236, 1177, 1118, 1085, 1012cm⁻¹ I-278 m.p. 151–154° C. ¹HNMR(CDCl₃) δ 1.69(s, 3H), 1.74(d, J=0.9Hz, 3H), 2.51–2.59(m, 2H), 2.75(s, 3H), 3.21(s, 3H), 3.54(s, 3H), 3.73(s, 3H), 3.84(s, 3H), 4.07 (t, J=6.9Hz, 2H), 5.21(m, 1H), 6.83(s, 1H), 7.00–7.08(m, 3H), 7.34–7.43(m, 4H) IR(KBr)3434, 2935, 1610, 1581, 1522, 1479, 1399, 1362, 1283, 1246, 1180, 1125, 1114, 1082, 1046cm⁻¹ I-279 m.p. 90–92° C. ¹HNMR(CDCl₃) δ 1.69(s, 3H), 1.75(s, 3H), 2.42(s, 3H), 2.49–2.56(m, 2H), 3.45(s, 3H), 3.74(s, 3H), 4.06(t, J=6.6 HZ, 2H), 5.22(m, 1H), 5.67 (s, 1H), 5.90(s, 1H), 6.46(s, 1H), 6.94–7.06(m, 3H), 7.25–7.28(m, 2H), 7.52–7.55(m, 2H) IR(KBr)3529, 3381, 2927, 1616, 1586, 1522, 1490, 1465, 1418, 1398, 1360, 1315, 1289, 1251, 1225, 1192, 1114, 1070, 1011cm⁻¹ I-280 m.p. 82–84° C. ¹HNMR(CDCl₃) δ 1.69(s, 3H), 1.75(s, 3H), 2.49–2.56(m, 2H), 3.45(s, 3H), 3.71(s, 3H), 3.85(s, 3H), 4.06(t, J=6.6Hz, 2H), 5.22(m, 1H), 5.67 (s, 1H), 5.82(s, 1H), 6.42(s, 1H), 6.92–7.09(m, 5H), 7.35–7.43(m, 2H) IR(KBr)3420, 3326, 2935, 1615, 1583, 1518, 1504, 1486, 1466, 1410, 1316, 1289, 1249, 1122, 1101, 1071, 1018cm⁻¹ I-281 m.p. 166–168° C. ¹HNMR(CDCl₃) δ 2.38(s, 3H), 2.69(s, 3H), 3.11(s, 3H), 3.54(s, 3H), 3.73(s, 3H), 3.84(s, 3H), 5.14(s, 2H), 6.83(s, 1H), 7.00–7.44(m, 11H) IR(KBr)3434, 2941, 1608, 1521, 1498, 1482, 1466, 1397, 1368, 1284, 1243, 1177, 1113, 1079, 1019cm⁻¹

TABLE 60 I-282 m.p. 109–111° C. ¹HNMR(CDCl₃) δ 2.39(s, 3H), 3.45(s, 3H), 3.71(s, 3H), 3.85(s, 3H), 5.10(s, 2H), 5.67(s, 1H), 5.83(s, 1H), 6.42(s, 1H), 6.95–7.41(m, 11H) IR(CHCl₃)3497, 2935, 1610, 1583, 1519, 1499, 1481, 1465, 1399, 1312, 1274, 1245, 1185, 1120, 1102, 1067, 1012cm⁻¹ I-283 ¹HNMR(CDCl₃) δ 2.38(s, 3H), 2.68(s, 3H), 3.12(s, 3H), 3.53(s, 1H), 3.77(s, 3H), 5.14(s, 2H), 6.83(s, 1H), 7.10–7.24(m, 5H), 7.33(d, J=8.4Hz, 1H), 7.34(d, J=8.4Hz, 2H), 7.40(d, J=2.1Hz, 1H)7.56–7.64(m, 2H) IR(KBr) 1603, 1520, 1482, 1367, 1297, 1277, 1251, 1232, 1176, 1120, 1084, 1012cm⁻¹ I-284 ¹HNMR(CDCl₃) δ 2.39(s, 3H), 3.45(s, 3H), 3.75(s, 3H), 5.10(s, 2H), 5.68(s, 1H), 5.88(s, 1H), 6.44(s, 1H), 6.95(dd, J=8.4&2.1Hz, 1H), 7.03 (d, J=8.4Hz, 1H), 7.07(d, J=2.1Hz, 1H), 7.08–7.29(m, 4H), 7.34(d, J=8.4Hz, 2H), 7.56–7.65(m, 2H)s IR(KBr)3504, 3330, 1604, 1596, 1490, 1461, 1455, 1424, 1360, 1318, 1242, 1223, 1121, 1071, 1009cm⁻¹ I-285 ¹HNMR(CDCl₃) δ 2.69(s, 3H), 3.13(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 5.19(s, 2H), 6.85(s, 1H), 7.05–7.15(m, 1H), 7.15(d, J=8.4Hz, 1H), 7.30–7.49(m, 10H) IR(KBr)1610, 1583, 1517, 1475, 1455, 1359, 1296, 1270, 1239, 1180, 1116, 1088, 1013cm⁻¹ I-286 ¹HNMR(CDCl₃) δ 3.47(s, 3H), 3.75(s, 3H), 5.15(s, 2H), 5.68(s, 1H), 5.89(s, 1H), 6.46(s, 1H), 6.95(dd, J=8.4&2.1Hz, 1H), 7.03(d, J=8.4Hz, 1H), 7.04–7.12(m, 2H), 7.35–7.51(m, 9H) IR(KBr)3543, 3346, 1612, 1586, 1566, 1518, 1502, 1479, 1407, 1362, 1320, 1239, 1110, 1068, 1006cm⁻¹ I-287 ¹HNMR(CDCl₃) δ 2.68(s, 3H), 3.14(s, 3H), 3.58(s, 3H), 3.81(s, 3H), 5.20(s, 2H), 6.88(s, 1H), 7.16(d, J=8.7Hz, 1H), 7.32–7.49(m, 7H), 7.60–7.68(m, 1H), 7.98–8.04(m, 1H), 8.24–8.29(m, 1H), 8.44–8.47(m, 1H) IR(KBr)1609, 1531, 1362, 1270, 1239, 1178, 1122, 1085, 1014cm⁻¹ I-288 ¹HNMR(CDCl₃) δ 3.49(s, 3H), 3.78(s, 3H), 5.17(s, 2H), 5.71(s, 1H), 5.83(s, 1H), 6.49(s, 1H))6.95(dd, J=12.3&1.2Hz, 1H), 7.02(d, J=12.3Hz, 1H), 7.08(d, J=1.2Hz, 1H), 7.33–7.50(m, 5H), 7.60–7.68(m, 1H), 7.97–8.06(m, 1H), 8.21–8.27(m, 1H), 8.52(s, 1H) IR(KBr)3528, 3358, 1588, 1527, 1499, 1454, 1406, 1348, 1314, 1241, 1122, 1070, 1009cm⁻¹

TABLE 61 I-289 ¹HNMR(CDCl₃) δ 2.68(s, 3H), 3.13(s, 3H), 3.55(s, 3H), 3.77(s, 3H), 5.19(s, 2H), 6.79–6.88(m, 1H), 6.86(s, 1H), 7.02–7.10(m, 2H), 7.15(d, J=8.4Hz, 1H), 7.26–7.50(m, 8H) IR(KBr)3479, 3388, 1623, 1603, 1518, 1478, 1396, 1358, 1176, 1118, 1081, 1013cm⁻¹ I-290 ¹HNMR(CDCl₃) δ 3.11(s, 3H), 3.45(s, 3H), 3.77(s, 3H), 5.17(s, 2H), 6.05(s, 1H), 6.46(s, 1H))7.00–7.18(m, 1H), 7.14(d, J=8.4Hz, 1H), 7.33–7.50(m, 9H), 7.52(d, J=2.1Hz, 1H) IR(KBr)3504, 1612, 1578, 1519, 1498, 1464, 1391, 1355, 1290, 1276, 1239, 1183, 1167, 1107, 1070, 1004cm⁻¹ I-291 ¹HNMR(CDCl₃+CD₃OD) δ 3.44(s, 3H), 3.75(s, 3H), 4.74(s, 2H), 5.13(s, 2H), 1H), 6.86–6.95(m, 3H), 6.99(d, J=8.7Hz, 1H), 7.30–7.48(m, 7H),7.52(d, J=8.7Hz, 2H) IR(KBr)3433, 1707, 1611, 1518, 1473, 1463, 1379, 1250, 1174, 1132, 1089, 1058, 1016cm⁻¹ I-292 ¹HNMR(CDCl₃+CD₃OD) δ 3.41(s, 3H), 3.62(s, 3H), 3.75(s, 3H), 4.74(s, 2H), 5.15(s, 2H), 6.87–7.01(m, 4H), 7.30–7.55(m, 9H) IR(KBr)3386, 1722, 1611, 1518, 1464, 1343, 1271, 1245, 1233, 1215, 1168, 1082, 1060, 1021cm⁻¹ I-293 ¹HNMR(CDCl₃) δ 2.38(s, 3H), 2.69(s, 3H), 3.12(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 5.14(s, 2H), 6.85(s, 1H), 7.05–7.45(m, 12H) IR(KBr)1607, 1584, 1519, 1479, 1401, 1364, 1348, 1280, 1237, 1178, 1164, 1115, 1081, 1016cm⁻¹ I-294 foam ¹HNMR(CDCl₃) δ 3.45(s, 3H), 3.75(s, 3H), 4.36(d, J=2.1Hz, 1H), 4.55(s, 2H), 4.76(d, J=2.1Hz, 1H), 6.45, (s, 1H), 6.92(d, J=8.7Hz, 2H), 6.99(d, J=8.4Hz, 1H), 7.20(dd, J=1.5and8.4Hz, 1H), 7.11(d, J=1.5Hz, 1H), 7.53(d, J=8.7Hz, 2H) IR(Nujol)3425, 1612, 1588, 1523, 1487, 1295, 1268, 1228, 1113, 1069, 825cm⁻¹ I-295 foam ¹HNMR(CDCl₃) δ 2.78(s, 3H), 3.21(s, 3H), 3.23(s, 3H), 3.55(s, 3H), 3.78(s, 3H), 4.79(d, J=6.6Hz, 2H), 6.21(t, J=6.6Hz, 1H), 6.85(s, 1H), 7.08(d, J=8.7Hz, 1H), 7.37(dd, J=8.7, 2.1Hz, 1H), 7.38(d, J=8.7Hz, 2H), 7.41(d, J=2.1Hz, 1H), 7.68(d, J=8.7Hz, 2H) IR(Nujol)1632, 1607, 1519, 1482, 1180, 1150, 1079, 1011, 976, 876, 814, 798cm⁻¹

TABLE 62 I-296 foam ¹HNMR(CD₃OD) δ 3.38(s, 3H), 3.68(s, 3H), 4.12(brs, 2H), 4.65(brs, 2H), 5.01(m, 2H), 6.43(s, 1H), 6.78(dd, J=8.7, 1.8Hz, 1H), 6.85(d, J=8.7, 2H), 6.86(d, J=1.8Hz, 1H), 6.94(d, J=8.4Hz, 1H), 7.46(d, J=8.7Hz, 2H) IR(Nujol)3411, 1612, 1591, 1520, 1485, 1461, 1253, 1223, 1115, 1008, 971, 944, 842, 810, 785cm⁻¹ I-297 foam ¹HNMR(CD₃OD) δ 3.38(s, 3H), 3.68(s, 3H), 4.73(d, J=5.1Hz, 2H), 4.23(d, J=5.1Hz, 2H), 5.83(m, 2H), 6.43(s, 1H), 6.79(dd, J=8.7, 1.8Hz, 1H), 6.85(d, J=8.7, 2H), 6.86(d, J=1.8 HZ, 1H), 6.94(d, J=8.7Hz, 2H) IR(Nujol)3393, 1611, 1588, 1523, 1489, 1460, 1248, 1114, 1071, 1013, 940, 824cm⁻¹ I-298 foam ¹HNMR(CD₃OD) δ 1.77(s, 3H), 3.38(s, 3H), 3.68(s, 3H), 4.00(s, 2H), 5.72(d, J=6.3 HZ, 2H), 5.81(t, J=6.3Hz, 1H), 6.43(s, 1H), 6.79(dd, J=8.7, 1.8Hz, 1H), 6.85(d, J=8.7, 2H), 6.85(d, J=1.8Hz, 1H), 6.94(d, J=8.4Hz, 1H), 7.46(d, J=8.7Hz, 2H) IR(Nujol)3384, 1608, 1585, 1523, 1494, 1457, 1262, 1242, 1227, 1116, 1078, 1008, 985, 822, 781cm⁻¹ I-299 foam ¹HNMR(CD₃OD) δ 1.87(s, 3H), 3.83(s, 3H), 3.68(s, 3H), 4.17(s, 2H), 4.69(d, J=6.6Hz, 2H), 5.68(t, J=6.3 HZ, 1H), 6.43(s, 1H), 6.79(dd, J=8.7, 1.8Hz, 1H), 6.85(d, J=8.4, 2H), 6.85(d, J=1.8Hz, 1H), 6.94(d, J=8.4Hz, 1H), 7.46(d, J=8.7Hz, 2H) IR(Nujol)3350, 3236, 1606, 1589, 1524, 1490, 1463, 1247, 1227, 1079, 1011, 992, 819, 790cm⁻¹ I-300 foam ¹HNMR(CDCl₃) δ 1.87(s, 3H), 2.10(s, 3H), 3.45(s, 3H), 3.74(s, 3H), 4.68(s, 2H), 4.71(d, J=6.0Hz, 2H), 5.77(t, J=6.0Hz, 1H), 6.44(s, 1H), 6.92(d, J=8.0Hz, 2H), 6.95(m, 2H), 7.07(brs, 1H), 7.53(d, J=6.0Hz, 2H) IR(Nujol)3409, 1724, 1612, 1587, 1523, 1489, 1460, 1239, 1114, 1071, 1012, 940, 825, 781cm⁻¹

TABLE 63 I-301 foam ¹HNMR(CD₃OD) δ 2.93(d, J=2.1Hz, 1H), 3.38(s, 3H), 3.68(s, 3H), 4.06(dd, J=9.9, 7.8 HZ, 1H), 4.20(dd, J=9.9, 3.6Hz, 1H), 4.74(ddd, J=7.8, 3.6, 2.1Hz, 1H), 6.44(s, 1H), 6.80(dd, J=8.4, 1.8Hz, 1H), 6.85(d, J=8.7, 2H), 6.87(d, J=1.8 HZ, 1H), 6.96(d, J=8.4Hz, 1H), 7.46(d, J=8.7Hz, 2H) IR(Nujol)3282, 1655, 1612, 1588, 1523, 1489, 1460, 1254, 1226, 1072, 1013, 940, 825cm⁻¹ I-302 foam ¹HNMR(CD₃OD) δ 3.30(s, 3H), 3.68(s, 3H), 4.75(d, J=5.1Hz, 2H), 6.44(s, 1H), 6.80(dd, J=8.4, 1.8Hz, 1H), 6.85(d, J=8.4, 2H), 6.92(d, J=1.8Hz, 1H), 6.99(d, J=8.7Hz, 1H), 7.42(t, J=5.1Hz, 1H), 7.46(d, J=8.4Hz, 2H) IR(Nujol)3474, 3316, 1678, 1611, 1584, 1523, 1487, 1458, 1268, 1231, 1115, 1171, 1011, 942, 824, 758cm⁻¹ I-303 foam ¹HNMR(CD₃OD) δ 1.24(d, j =7.2Hz, 3H), 3.38(s, 3H), 3.68(s, 3H), 4.12(q, J=7.2Hz, 2H), 4.75(d, J=4.8Hz, 2H), 6.43(s, 1H), 6.80(dd, J=8.4, 1.8Hz, 1H), 6.85(d, J=8.7, 2H), 6.91(d, J=1.8Hz, 1H), 6.99(d, J=8.4Hz, 2H), 7.46(d, J=8.7Hz, 2H), 7.52(t, J=4.8Hz, 1H) IR(Nujol)3306, 1715, 1612, 1587, 1523, 1487, 1460, 1266, 1232, 1115, 1070, 824, 760cm⁻¹ I-304 foam ¹HNMR(CDCl₃) δ 2.34(s, 3H), 2.38(s, 3H), 2.70(s, 3H), 3.07(s, 3H), 3.21(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 5.13(s, 2H), 6.84(s, 1H), 7.03( d, J=7.8Hz, 1H), 7.06(s, 1H), 7.18(d, J=8.4Hz, 1H), 7.28(d, J=7.8Hz, 1H), 7.36(dd, J=2.1, 8.4Hz, 1H), 7.38(d, J=8.7Hz, 2H), 7.40(d, J=2.1Hz, 1H), 7.68(d, J=8.7Hz, 2H) IR(KBr)1611, 1518, 1480, 1365, 1177, 1151, 1080, 876, 816cm⁻¹ I-305 foam ¹HNMR(CDCl₃) δ 1.25(d, J=6.9Hz, 6H), 2.67(s, 3H), 2.93(q, J=6.9Hz, 1H)3.13(s, 3H), 3.21(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 5.15(s, 2H), 6.84(s, 1H), 7.16(d, J=8.7Hz, 1H), 7.26(d, J=8.4Hz, 2H), 7.34(dd, J=2.4, 8.7Hz, 1H), 7.38(d, J=8.4Hz, 4H), 7.40(d, J=2.4Hz, 1H), 7.68 (d, J=8.4Hz, 2H) IR(KBr)1609, 1519, 1481, 1365, 1177, 1151, 1080, 875, 819cm⁻¹

TABLE 64 I-306 foam ¹HNMR(CDCl₃) δ 2.62(s, 3H), 3.15(s, 3H), 3.21(s, 3H), 3.55(s, 3H), 3.77(s, 3H), 5.36(s, 2H), 6.84(s, 1H), 7.18(d, J=8.7Hz, 1H), 7.26(s, 1H), 7.33(dd, J=2.1, 8.4Hz, 1H), 7.38(d, J=8.7Hz, 2H), 7.41(d, J=2.1Hz, 1H), 7.51(m, 2H), 7.57(dd, J=1.8, 8.4Hz, 1H), 7.68(d, J=8.7Hz, 2H), 7.84–7.93(m, 4H) IR(KBr)1608, 1519, 1480, 1364, 1177, 1151, 1079, 876, 819, 797cm⁻¹ I-307 foam ¹HNMR(CDCl₃) δ 2.64(s, 3H), 3.21(s, 3H), 3.28(s, 3H), 3.55(s, 3H), 3.77(s, 3H),5.51(s, 2H), 6.83(s, 1H), 7.18(d, J=8.4Hz, 1H), 7.31(dd, J=2.4, 8.4Hz, 1H), 7.37(d, J=8.7Hz, 2H), 7.42(d, J=2.4Hz, 1H), 7.58(dt, J=2.4, 7.2Hz, 1H), 7.67(d, J=8.7Hz, 2H), 7.74(d, J=8.4Hz, 1H), 7.76(dt, J=2.4, 7.2Hz, 1H), 7.85(d, J=7.2Hz, 1H), 8.06(d, J=7.2Hz, 1H), 8.23(d, J=7.2Hz, 1H) IR(KBr)1603, 1519, 1480, 1365, 1177, 1151, 1080, 876, 824, 797cm⁻¹ I-308 foam ¹HNMR(CDCl₃) δ 2.76(s, 3H), 3.17(s, 3H), 3.21(s, 3H), 3.55(s, 3H), 3.78(s, 3H),5.25(s, 2H), 6.85(s, 1H), 7.12(d, J=8.7Hz, 1H), 7.35(dd, J=2.1, 8.4Hz, 1H), 7.38(d, J=8.7Hz, 2H), 7.42(d, J=2.1Hz, 1H), 7.61(d, J=8.7Hz, 2H), 7.67(d, J=8.4Hz, 2H), 7.68(d, J=8.7Hz, 2H) IR(KBr) 1610, 1522, 1489, 1402, 1245, 1181, 1164, 1110, 1071, 821, 805cm⁻¹ I-309 m.p. 221–222° C. ¹HNMR(CDCl₃) δ 2.36(s, 3H), 2.38(s, 3H), 3.46(s, 3H), 3.75(s, 3H), 5.09(s, 2H), 6.45(s, 1H), 6.92(d, J=8.4Hz, 2H), 6.98(dd, J=2.1, 8.1Hz, 1H), 7.06(d, J=8.4Hz, 1H), 7.08(d, J=2.1Hz, 1H), 7.08(s, 1H), 7.28(d, J=8.4Hz, 1H), 7.53(d, J=8.4Hz, 2H) IR(KBr)3475, 1610, 1522, 1489, 1402, 1245, 1181, 1164, 1110, 1071, 821, 805cm⁻¹ I-310 m.p. 153–155° C. ¹HNMR(CDCl₃) δ 1.27(d, J=6.9Hz, 6H), 2.95(q, J=6.9Hz, 1H), 3.45(s, 3H), 3.74(s, 3H), 5.11(s, 2H), 6.45(s, 1H), 6.91(d, J=8.4Hz, 2H), 6.96(dd, J=2.1, 8.1Hz, 1H), 7.03(d, J=8.1Hz, 1H), 7.08(d, J=2.1Hz, 1H), 7.28(d, J=8.1Hz, 2H), 7.38(d, J=8.1Hz, 2H), 7.53(d, J=8.4Hz, 2H) IR(KBr)3486, 1611, 1522, 1489, 1265, 1113, 1072, 1011, 823cm⁻¹

TABLE 65 I-311 m.p. 176–177° C. ¹HNMR(CDCl₃) δ 3.45(s, 3H), 3.75(s, 3H), 5.32(s, 2H), 6.45(s, 1H), 6.91(d, J=8.4Hz, 2H), 6.97(dd, J=2.1, 8.4Hz, 1H), 7.06(d, J=8.4Hz, 1H), 7.10(d, J=2.1Hz, 1H), 7.53(d, J=8.4Hz, 2H), 7.50–7.57(m, 3H), 7.82–7.92(m, 4H) IR(KBr)3476, 1610, 1522, 1488, 1469, 1401, 1263, 1246, 1173, 1112, 1073, 1014, 1002, 819, 806cm⁻¹ I-312 m.p. 235–237° C. ¹HNMR(CDCl₃) δ 3.44(s, 3H), 3.73(s, 3H), 5.49(s, 2H), 6.44(s, 1H), 6.92(d, J=8.4Hz, 2H), 6.93(dd, J=2.1, 8.4Hz, 1H), 7.14(d, J=2.1Hz, 1H), 7.18(d, J=8.4Hz, 1H), 7.38(d, J=8.4Hz, 1H), 7.52(d, J=8.4Hz, 2H), 7.58(dd, J=7.2, 7.2Hz, 1H), 7.77(dd, J=7.2, 7.2Hz, 1H), 7.85(d, J=7.2Hz, 1H), 8.21(d, J=7.2Hz, 1H), 8.22(d, J=7.2Hz, 1H) IR(KBr)3378, 1609, 1522, 1488, 1268, 1229, 1205, 1114, 1072, 1016, 825, 782cm⁻¹ I-313 m.p. 159–161° C. ¹HNMR(CDCl₃) δ 3.45(s, 3H), 3.75(s, 3H), 5.22(s, 2H), 6.45(s, 1H), 6.92(d, J=8.4Hz, 2H), 6.96(br.s, 2H), 7.11(br.s, 1H), 7.53(d, J=8.4Hz, 2H), 7.57(d, J=8.4Hz, 2H), 7.68(d, J=8.4Hz, 2H), IR(KBr)3433, 1613, 1523, 1490, 1326, 1251, 1166, 1113, 1066, 1014, 825cm⁻¹ I-314 m.p. 92–93° C. ¹HNMR(CDCl₃) δ 1.63(s, 3H), 1.74(s, 3H), 2.34–2.39(m, 1H), 2.67–2.72(m, 2H), 3.47(s, 3H), 3.74(s, 3H), 4.52–4.54(m, 2H), 5.30–5.33 (m, 2H), 6.78–6.97(m, 4H), 7.20(d, J=7.2Hz, 1H), 7.56(d, J=8.0Hz, 2H) IR(KBr)3410, 2932, 1613, 1519, 1473, 1444, 1390, 1263, 1228, 1174cm⁻¹ I-315 m.p. 85–86° C. ¹HNMR(CDCl₃) δ 1.76(s, 3H), 1.83(s, 3H), 2.17–2.40(m, 1H), 2.65–2.71(m, 2H), 3.24(s, 3H), 3.46(s, 3H), 3.80(s, 3H), 4.50–4.52(m, 2H), 6.70(s, 1H), 7.28–7.43(m, 5H), 7.73(d, J=8.6Hz, 2H) IR(KBr)3432, 2938, 1731, 1513, 1469, 1366, 1180, 1151, 970, 868cm⁻¹

TABLE 66 I-316 m.p. 179–180° C. ¹HNMR(CDCl₃) δ 1.72(s, 3H), 1.76(s, 3H), 2.15–2.35(m, 1H), 2.61–2.70(m, 2H), 3.46(s, 3H), 3.76(s, 3H), 4.47–4.50(m, 2H), 6.68(s, 1H), 7.17–7.52(m, 5H), 7.69(d, J=8.4Hz, 2H) IR(KBr)3427, 2934, 1612, 1576, 1519, 1465, 1443, 1415, 1376, 1228, 1174, 846cm⁻¹ I-317 m.p. 141–142° C. ¹HNMR(CDCl₃) δ 1.75(s, 3H), 1.80(s, 3H), 3.21(s, 3H), 3.39(s, 3H), 3.68(s, 3H), 3.77(s, 3H), 4.61(d, J=7.2Hz, 2H), 5.50(t, J=7.0Hz, 1H), 6.93(s, 1H), 6.99–7.33(m, 5H), 7.57–7.65(m, 2H) IR(KBr)3432, 2938, 1724, 1519, 1474, 1365, 1346, 1294, 1262, 1244, 1220, 1163, 1119, 1059, 953, 842, 805cm⁻¹ I-318 m.p. 127–128° C. ¹HNMR(CDCl₃) δ 1.68(s, 3H), 1.74(s, 3H), 2.54(dt, J=4.2, 4.6Hz, 2H), 3.20(s, 3H), 3.39(s, 3H), 3.68(s, 3H), 3.76(s, 3H), 4.05(t, J=4.4Hz, 2H), 5.21(t, J=4.6Hz, 1H), 6.93(s, 1H), 7.00(d, J=5.6Hz, 1H), 7.11–7.18(m, 2H), 7.25–7.35(m, 3H), 7.61(dd, J=3.8, 5.8Hz) IR(KBr)3447, 2974, 2940, 1740, 1519, 1471, 1365, 1343, 1295, 1262, 1226, 1182, 1161, 1119, 1058, 952, 843, 814cm⁻¹ I-319 m.p. 171–172° C. ¹HNMR(CDCl₃) δ 2.38(s, 3H), 3.10(s, 3H), 3.39(s, 3H), 3.66(s, 3H), 3.77(s, 3H), 5.11(s, 2H), 6.93(s, 1H), 7.07–7.36(m, 9H), 7.61(dd, J=3.4, 5.6Hz, 2H) IR(KBr)3431, 2937, 1724, 1519, 1474, 1440, 1346, 1296, 1259, 1243, 1222, 1165, 1121, 1060, 953, 843, 804cm⁻¹ I-320 m.p. 155–156° C. ¹HNMR(CDCl₃) δ 3.40(s, 3H), 3.69(s, 3H), 3.77(s, 3H), 5.13(s, 2H), 5.70(brs, 1H), 6.82–7.42(m, 5H), 7.39–7.42(m, 5H), 7.62(dd, J=5.4, 8.6Hz) IR(KBr)3550, 3481, 2956, 1723, 1519, 1467, 1435, 1344, 1285, 1261, 1238, 1223, 1130, 1058, 1013, 840cm⁻¹

TABLE 67 I-321 m.p. 159–160° C. ¹HNMR(CDCl₃) δ 3.11(s, 3H), 3.40(s, 3H), 3.66(s, 3H), 3.77(s, 3H), 5.16(s, 2H), 6.93(s, 1H), 7.07–7.49(m, 5H), 7.62(dd, J=3.0, 8.4Hz, 2H) IR(KBr)3441, 2952, 1732, 1519, 1469, 1445, 1381, 1356, 1342, 1291, 1273, 1243, 1226, 1162, 1119, 1081, 1057, 999, 950, 842, 805cm⁻¹ I-322 m.p. 160–161° C. ¹HNMR(CDCl₃) δ 2.37(s, 3H), 2.93(s, 3H), 3.19(s, 3H), 3.22(s, 3H), 3.55(s, 3H), 3.79(s, 3H), 5.23(s, 2H), 6.86(s, 1H), 7.20(d, J=8.1Hz, 2H), 7.30(d, J=8.1Hz, 2H), 7.36–7.41(m, 2H), 7.64–7.70(m, 2H), 7.74(d, J=2.1Hz, 1H), 7.83(d, J=2.1Hz, 1H), 10.16(s, 1H) IR(CHCl₃)3027, 2940, 1692, 1473, 1373, 1227, 1152, 1085cm⁻¹ I-323 powder ¹HNMR(CDCl₃) δ 2.37(s, 3H), 2.86(s, 3H), 3.13(s, 3H), 3.21(s, 3H), 3.54(s, 3H), 3.79(s, 3H), 4.64(s, 2H), 5.11(s, 2H), 6.85(s, 1H), 7.21 (d, J=7.8Hz, 2H), 7.32–7.44(m, 6H), 7.65–7.70(m, 2H) IR(CHCl₃)3026, 2939, 1475, 1372, 1228, 1178, 1151, 1084cm⁻¹ I-324 powder ¹HNMR(CDCl₃) δ 1.89–1.98(brs, 1H), 2.39(s, 3H), 3.45(s, 3H), 3.75(s, 3H), 4.77(s, 2H), 5.01(s, 3H), 5.46(s, 1H), 5.99(s, 1H), 6.45(s, 1H), 6.45–6.95(m, 2H), 7.05(s, 2H), 7.24(d, J=8.1Hz, 2H), 7.38(d, J=8.1Hz, 2H), 7.50–7.56(m, 2H) IR(CHCl₃)3514, 2937, 1731, 1613, 1522, 1484, 1403, 1228, 1173, 1082cm⁻¹ I-325 powder ¹HNMR(CDCl₃) δ 2.31(s, 3H), 2.88(s, 3H), 3.07(s, 3H), 3.22(s, 3H), 3.51(s, 3H), 3.74(s, 3H), 5.23(s, 2H), 6.83(s, 1H), 7.11–7.18(m, 2H), 7.32–7.41(m, 4H), 7.62–7.68(m, 3H), 8.03(s, 1H) IR(CHCl₃)3026, 2939, 1742, 1472, 1374, 1227, 1179, 1129, 1085cm⁻¹

TABLE 68 I-326 powder ¹HNMR(CD₃OD) δ 2.33(s, 3H), 3.38(s, 3H), 3.68(s, 3H), 5.11(s, 2H), 6.44(s, 1H), 6.82–6.88(m, 2H), 6.99(d, J=1.8Hz, 1H), 7.13–7.19( m, 3H), 7.42–7.50(m, 4H) IR(KBr)3411, 2935, 1680, 1611, 1520, 1457, 1404, 1281, 1230, 1114cm⁻¹ I-327 powder ¹HNMR(CDCl₃) δ 1.72(s, 3H), 1.79(s, 3H), 3.12(s, 3H), 3.21(s, 3H), 3.27(s, 3H), 3.52(s, 3H), 3.53(s, 3H), 4.81(d, J=7.5Hz, 2H), 5.51(m, 1H), 7.38–7.43(m, 2H), 7.45–7.50(m, 2H), 7.80(d, J=2.1Hz, 1H), 7.97(d, J=2.1Hz, 1H) IR(CHCl₃)3032, 2941, 1543, 1377, 1209cm⁻¹ I-328 m.p. 205–206° C. ¹HNMR(CDCl₃) δ 1.75(s, 3H), 1.80(s, 3H), 3.41(s, 3H), 3.47(s, 3H), 4.66(d, J=6.6Hz, 2H), 5.06(s, 1H), 5.53(m, 1H), 6.33(s, 1H), 6.89–6.95 (m, 2H), 7.28–7.34(m, 2H), 7.38–7.40(m, 1H), 7.99(d, J=2.1Hz, 1H), 10.83(d, J=0.6Hz, 1H) IR(KBr)3476, 2940, 1614, 1532, 1371, 1238, 1094, 1035cm⁻¹ I-329 m.p. 144–145° C. ¹HNMR(CDCl₃) δ 2.83(s, 3H)3.22(s, 3H), 3.28(s, 3H), 3.55(s, 3H), 3.79(s, 3H), 6.86(s, 1H), 7.37–7.45(m, 3H), 7.47–7.53(m, 3H), 7.65–7.70 (m, 2H) IR(KBr)3434, 3019, 2939, 1515, 1480, 1370, 1176, 1150, 1081cm⁻¹ I-330 amorphous ¹HNMR(CDCl₃) δ 1.68(s, 3H), 1.74(s, 3H), 2.54(q, J=7.2Hz, 2H), 3.21(s, 3H), 3.41(s, 3H), 3.65(s, 3H), 3.77(s, 3H), 4.03(t, J=7.2Hz, 2H), 5.23(t, J=7.2Hz, 1H), 6.94(s, 1H), 6.98(t, J=8.6Hz, 1H), 7.05(ddd, J=8.6, 2.1, 0.9Hz, 1H), 7.14(dd, J=12.0, 2.1Hz, 1H), 7.38(d, J=8.7Hz, 2H), 7.71(d, J=8.7Hz, 2H) IR(CHCl₃)1732, 1521, 1471, 1375, 1262, 1230, 1150, 1061, 874cm⁻¹

TABLE 69 I-331 m.p. 146–148° C. ¹HNMR(CDCl₃) δ 1.56(s, 3H), 1.80(s, 3H), 3.21(s, 3H), 3.41(s, 3H), 3.65(s, 3H), 3.77(s, 3H), 4.61(d, J=6.9Hz, 2H), 5.54(t, J=6.9Hz, 1H), 6.94(s, 1H), 6.98(t, J=8.4Hz, 1H), 7.05(ddd, J=8.4, 2.4, 0.9Hz, 1H), 7.14(dd, J=12.0, 2.4Hz, 1H), 7.38(d, J=8.7Hz, 2H), 7.71(d, J=8.7Hz, 2H) IR(KBr)1736, 1519, 1471, 1357, 1257, 1150, 1061, 984, 872cm⁻¹ I-332 m.p. 170–171° C. ¹HNMR(DMSO-d₆) δ 1.73(s, 3H), 1.77(s, 3H), 3.31(s, 3H), 3.73(s, 3H), 4.62(d, J=7.0Hz, 2H), 5.48(t, J=7.0Hz, 1H), 6.87(d, J=8.9Hz, 2H), 7.00(s, 1H), 7.03(ddd, J=8.7, 2.3, 0.9Hz, 1H), 7.10(dd, J=12.3, 2.3Hz, 1H), 7.18(t, J=8.7Hz, 1H), 7.48(d, J=8.9Hz, 2H), 9.60(s, 1H), 12.9 (brs, 1H) IR(KBr)3258, 1687, 1615, 1523, 1465, 1373, 1260, 1233, 1057, 994, 835, 823cm⁻¹ I-333 m.p. 172–174° C. ¹HNMR(CDCl₃) δ 3.21(s, 3H), 3.41(s, 3H), 3.61(s, 3H), 3.77(s, 3H), 5.17(s, 2H), 6.94(s, 1H), 7.01–7.04(m, 2H), 7.13–7.18(m, 1H), 7.33–7.49 (m, 7H), 7.70(d, J=9.0Hz, 2H) IR(KBr)1725, 1522, 1463, 1346, 1261, 1230, 1147, 1058, 878, 756cm⁻¹ I-334 m.p. 149–151° C. ¹HNMR(CDCl₃) δ 2.36(s, 3H), 3.21(s, 3H), 3.41(s, 3H), 3.61(s, 3H), 3.77(s, 3H), 5.13(s, 2H), 6.93(s, 1H), 7.00–7.03(m, 2H), 7.12–7.17( m, 1H), 7.20(d, J=8.4Hz, 2H), 7.35(d, J=8.4Hz, 2H), 7.38(d, J=8.7Hz, 2H), 7.70(d, J=8.7Hz, 2H) IR(KBr)1731, 1519, 1472, 1370, 1298, 1152, 1058, 874, 791cm⁻¹

TABLE 70 I-335 m.p. 173–174° C. ¹HNMR(DMSO-d₆) δ 1.64(s, 3H), 1.70(s, 3H), 2.45(q, J=6.9Hz, 2H), 3.31(s, 3H), 3.73(s, 3H), 4.04(t, J=6.9Hz, 2H), 5.22(t, J=6.9Hz, 1H), 6.87(d, J=8.7Hz, 2H), 6.99(s, 1H), 7.03(ddd, J=8.7, 2.1, 0.9Hz, 1H), 7.10(dd, J=12.3, 2.1Hz, 1H), 7.16(t, J=8.7Hz, 1H), 7.48(d, J=8.7Hz, 2H), 9.61(s, 1H), 12.9(brs, 1H) IR(KBr)3303, 1696, 1523, 1473, 1371, 1261, 1241, 1061, 1009, 839cm⁻¹ I-336 m.p. 222–224° C. ¹HNMR(DMSO-d₆) δ 3.31(s, 3H), 3.73(s, 3H), 5.20(s, 2H), 6.87(d, J=8.7Hz, 2H), 7.00(s, 1H), 7.03–7.07(m, 1H), 7.13(dd, J=12.3, 2.1Hz, 1H), 7.26(t, J=8.7Hz, 1H), 7.36–7.52(m, 7H), 9.61(s, 1H), 12.9(brs, 1H) IR(KBr)3268, 1689, 1523, 1465, 1374, 1261, 1055, 836cm⁻¹ I-337 m.p. 205–206° C. ¹HNMR(DMSO-d₆) δ 2.32(s, 3H), 3.31(s, 3H), 3.72(s, 3H), 5.15(s, 2H), 6.87(d, J=8.7Hz, 2H), 6.99(s, 1H), 7.04(ddd, J=9.0, 1.9, 0.9Hz, 1H), 7.12(dd, J=12.3, 1.9Hz, 1H), 7.23(d, J=8.0Hz, 2H), 7.24(t, J=9.0Hz, 1H), 7.38(d, J=8.0Hz, 2H), 7.48(d, J=8.7Hz, 2H), 9.60(s, 1H), 12.9(brs, 1H) IR(KBr)3303, 1696, 1523, 1464, 1261, 1241, 1056, 993, 838, 811, 791cm⁻¹ I-338 m.p. 120–121° C. ¹HNMR(CDCl₃) δ 3.13(s, 3H), 3.50(s, 3H), 3.78(s, 3H), 5.08(s, 1H), 5.20(s, 2H), 6.90(m, 2H), 7.09(s, 1H), 7.15–7.19(m, 3H), 7.37–7.50( m, 5H), 7.56(dd, J=10.8, 2.1Hz, 1H), 7.64(d, J=2.4Hz, 1H), 9.90(s, 1H) IR(KBr)3460, 2934, 1694, 1609, 1585, 1518, 1467, 1442, 1348, 1295, 1273, 1255, 1238, 1171, 1123, 1075, 1003, 960, 828, 807, 755, 700, 653, 582, 522cm⁻¹ I-339 m.p. 256–258° C. ¹HNMR(DMSO-d₆) δ 3.34(s, 3H), 3.35(s, 3H), 3.72(s, 3H), 5.28(s, 2H), 6.75(d, J=8.1Hz, 2H), 7.05–7.11(m, 3H), 7.36–7.45(m, 4H), 7.53 (d, J=8.1Hz, 2H), 7.60–7.66(m, 2H), 9.44(s, 1H), 12.84(s, 1H) IR(KBr)3459, 2940, 2563, 1706, 1612, 1522, 1469, 1349, 1294, 1258, 1185, 1114, 1082, 1063, 1000, 961, 919, 827, 756, 699, 524cm⁻¹

TABLE 71 I-340 m.p. 165–166° C. ¹HNMR(CDCl₃) δ 3.14(s, 3H), 3.19(s, 3H), 3.51(s, 3H), 3.76(s, 3H), 5.21(s, 2H), 7.11(s, 1H), 7.17(d, J=8.4Hz, 1H), 7.29–7.50(m, 9H), 7.57 (dd, J=8.1, 2.1Hz, 1H), 7.65(d, J=2.1Hz, 1H), 10.02(s, 1H) IR(CHCl₃)2938, 2844, 1698, 1613, 1590, 1515, 1469, 1372, 1331, 1293, 1255, 1174, 1150, 1122, 1092, 1005, 969, 873, 816cm⁻¹ I-341 m.p. 195–197° C. ¹HNMR(CDCl₃) δ 3.13(s, 3H), 3.18(s, 3H), 3.47(s, 3H), 3.77(s, 3H), 5.20(s, 2H), 6.97(s, 1H), 7.17(d, J=8.7Hz, 1H), 7.30–7.50(m, 9H), 7.58 (dd, J=8.7, 1.8Hz, 1H), 7.67(d, J=1.8Hz, 1H) IR(CHCl₃)2938, 1740, 1707, 1601, 1516, 1472, 1371, 1293, 1260, 1174, 1149, 1117, 1082, 1060, 1002, 971, 875cm⁻¹ I-342 m.p. 207–209° C. ¹HNMR(CD₃OD) δ 3.40(s, 3H), 3.72(s, 3H), 5.21(s, 2H), 6.76–6.78(m, 2H), 6.97(s, 1H), 7.01–7.17(m, 4H), 7.31–7.52(m, 6H) IR(KBr)3366, 1705, 1612, 1591, 1522, 1473, 1434, 1375, 1253, 1234, 1130, 1084, 1061, 998, 918, 864, 835, 813, 792, 743, 697, 648, 526cm⁻¹ I-343 m.p. 206–208° C. ¹HNMR(CDCl₃) δ 3.14(s, 3H), 3.48(s, 3H), 3.72(s, 3H), 5.20(s, 2H), 5.48(br, 1H), 6.85–6.89(m, 3H), 7.15–7.19(m, 3H), 7.37–7.51(m, 8H), 7.56(dd, J=8.4, 2.4Hz, 1H), 7.68(d, J=2.4Hz, 1H) IR(CHCl₃)3320, 2938, 1612, 1520, 1474, 1371, 1292, 1257, 1172, 1120, 1090, 1005, 972, 857, 837, 818cm⁻¹ I-344 m.p. 187–190° C. ¹HNMR(CDCl₃) δ 2.33(s, 3H), 3.13(s, 3H), 3.50(s, 3H), 3.76(s, 3H), 5.20(s, 2H), 7.10(s, 1H), 7.15–7.19(m, 3H), 7.28–7.50(m, 7H), 7.56( dd, J=8.7, 2.4Hz, 1H), 7.64(d, J=2.4Hz, 1H), 9.93(s, 1H) IR(CHCl₃)2930, 2836, 1750, 1695, 1588, 1513, 1465, 1369, 1329, 1220, 1166, 1122, 1091, 1003, 962, 912, 848, 813cm⁻¹

TABLE 72 I-345 m.p. 218–220° C. ¹HNMR(DMSO-d₆) δ 2.29(s, 3H), 3.36(s, 3H), 3.37(s, 3H), 3.76(s, 3H), 5.29(s, 2H), 7.11–7.16(m, 3H), 7.31–7.46(m, 6H), 7.52–7.55(m, 2H), 7.62–7.68(m, 2H), 13.00(br, 1H) IR(KBr)3433, 2940, 2600, 1757, 1713, 1652, 1611, 1518, 1471, 1365, 1295, 1260, 1216, 1200, 1171, 1117, 1082, 1061, 1022, 998, 975, 916, 897, 829, 804, 735, 697, 525cm⁻¹ I-346 m.p. 206–208° C. ¹HNMR(CDCl₃) δ 2.31(s, 3H), 3.13(s, 3H), 3.45(s, 3H), 3.58(s, 3H), 3.76(s, 3H), 5.19(s, 2H), 6.95(s, 1H), 7.08–7.16(m, 3H), 7.34–7.50( m, 7H), 7.57(dd, J=8.7, 2.4Hz, 1H), 7.67(d, J=2.4Hz, 1H) IR(CHCl₃)2939, 1732, 1613, 1599, 1518, 1468, 1371, 1290, 1169, 1117, 1081, 1064, 1004, 972, 961, 905, 847, 828cm⁻¹ I-347 m.p. 201–203° C. ¹HNMR(DMSO-d₆) δ 1.72(s, 3H), 1.76(s, 3H), 3.34(s, 3H), 3.63(s, 3H), 4.51(d, J=4.2Hz, 2H), 5.49(t, J=4.6Hz, 1H), 6.66(s, 1H), 6.76(s, 2H), 6.86(s, 1H), 7.23–7.29(m, 2H), 7.62–7.66(m, 2H) IR(KBr)3431, 2935, 1575, 1516, 1462, 1444, 1421, 1397, 1375, 1224, 1159, 1063, 837cm⁻¹ I-348 m.p. 265–266° C. ¹HNMR(DMSO-d₆) δ 2.31(s, 3H), 3.33(s, 3H), 3.62(s, 3H), 5.03(s, 2H), 6.66(s, 1H), 6.72–6.90(m, 4H), 7.18–7.28(m, 3H), 7.38(d, J=5.2Hz, 2H), 7.64(dd, J=4.0, 5.4Hz, 2H) IR(KBr)3428, 2925, 1575, 1516, 1463, 1442, 1396, 1374, 1248, 1221, 1129, 1087, 1068cm⁻¹ I-349 m.p. 262–263° C. ¹HNMR(DMSO-d₆) δ 1.64(s, 3H), 1.70(s, 3H), 2.43(dt, J=4.6, 5.0Hz, 2H), 3.34(s, 3H), 3.62(s, 3H), 3.91(t, J=4.8Hz, 2H), 5.25(t, J=4.6Hz, 1H), 6.70(s, 1H), 6.75(s, 2H), 6.87(s, 1H), 7.23–7.29(m, 2H), 7.64(dd, J=2.0, 5.8Hz, 2H) IR(KBr)3430, 2934, 1575, 1516, 1464, 1443, 1422, 1398, 1375, 14246, 1225, 1065, 1015cm⁻¹

TABLE 73 I-350 ¹HNMR(CDCl₃) δ 1.76(s, 3H), 1.81(d, J=0.6Hz, 3H), 2.54(s, 3H), 2.73(s, 3H), 3.23(s, 3H), 3.54(s, 3H), 3.77(s, 3H), 4.63(d, J=6.6Hz, 2H), 5.49(m, 1H), 6.85(s, 1H), 7.09(d, J=8.4Hz, 1H), 7.30–7.40(m, 4H), 7.53–7.59(m, 2H) IR(CHCl₃)2936, 1606, 1515, 1475, 1366, 1116, 1078, 970, 875, 820cm⁻¹ I-351 ¹HNMR(CDCl₃) δ 1.68(s, 3H), 1.74(d, J=0.9Hz, 3H), 2.48–2.60(m, 5H), 2.75(s, 3H), 3.21(s, 3H), 3.54(s, 3H), 3.77(s, 3H), 4.07(t, J=6.9Hz, 2H), 5.21(m, 1H), 6.85(s, 1H), 7.07(d, J=8.7Hz, 1H), 7.30–7.42(m, 4H), 7.53–7.59(m, 2H) IR(CHCl₃)2928, 1607, 1517, 1476, 1367, 1267, 1118, 1080, 1014, 971, 892, 822cm⁻¹ I-352 m.p. 201–203° C. ¹HNMR(CDCl₃) δ 3.35(s, 3H), 3.75(s, 3H), 3.76(s, 3H), 5.26(s, 2H), 6.79–6.83(m, 2H), 6.97(s, 1H), 7.01(s, 1H), 7.31–7.54(m, 10H), 9.45 (s, 1H) IR(KBr)3600–2800(br), 1610, 1525, 1492, 1462, 1377, 1337, 1298, 1208, 1171, 1114, 1054, 1031cm⁻¹ I-353 m.p. 141–143° C. ¹HNMR(CDCl₃) δ 3.56(s, 3H), 3.78(s, 3H), 3.80(s, 3H), 4.86(s, 1H), 5.26(s, 2H), 6.88–6.92(m, 2H), 6.92(s, 1H), 6.93(s, 1H), 7.24–7.29( m, 2H), 7.36–7.41(m, 1H), 7.45–7.50(m, 2H) IR(KBr)3600–2800(br), 1612, 1524, 1491, 1463, 1448, 1378, 1263, 1205, 1177, 1153, 1071, 1053, 1026cm⁻¹ I-354 m.p. 115–115.5° C. ¹HNMR(CDCl₃) δ 3.19(s, 3H), 3.56(s, 3H), 3.79(s, 3H), 3.80(s, 3H), 5.27(s, 2H), 6.93(s, 1H), 6.94(s, 1H), 7.25–7.27(m, 2H), 7.32–7.40( m, 3H), 7.60–7.64(m, 2H) IR(KBr)3600–2800(br), 1524, 1492, 1463, 1379, 1266, 1210, 1174, 1154, 1126, 1082, 1053, 1029cm⁻¹ I-355 m.p. 139–140° C. ¹HNMR(CDCl₃) δ 1.77(d, J=0.6Hz, 3H), 1.81(d, J=0.9Hz, 3H), 3.82(s, 6H), 4.64(d, J=6.9Hz, 2H), 5.52–5.57(m, 1H), 6.95(s, 1H), 6.97( s, 1H), 7.04(t, J=8.4Hz, 1H), 7.26–7.31(m, 1H), 7.37(dd, J=2.1, 12.6Hz, 1H), 7.73–7.77(m, 2H), 8.26–8.31(m, 2H) IR(KBr)3600–2800(br), 1593, 1524, 1508, 1486, 1464, 1380, 1355, 1278, 1264, 1211, 1054, 1029cm⁻¹

TABLE 74 I-356 foam ¹HNMR(CDCl₃) δ 2.68(s, 3H), 3.13(s, 3H), 3.53(s, 3H), 3.78(s, 3H), 5.19(s, 2H), 6.83(s, 1H), 7.10–7.19(m, 3H), 7.30–7.50(m, 7H), 7.56–7.64 (m, 2H) IR(KBr)1607, 1520, 1482, 1365, 1232, 1177, 1119, 1082, 1013cm⁻¹ I-357 ¹HNMR(CDCl₃) δ 2.39(s, 3H), 3.48(s, 3H), 3.75(s, 3H), 5.11(s, 2H), 5.67(s, 1H), 5.88(s, 1H), 6.46(s, 1H), 6.95(d.d, J=8.7&1.8Hz, 1H), 7.02–7.11(m, 1H), 7.03(d, J=8.7Hz, 1H), 7.07(d, J=1.8Hz, 1H), 7.22(d, J=8.7Hz, 2H), 7.34(d, J=8.7Hz, 2H), 7.36–7.47(m, 3H)IR(KBr) 3546, 3511, 1611, 1586, 1517, 1478, 1405, 1360, 1318, 1240, 1109, 1068, 1007cm⁻¹ I-358 ¹HNMR(CDCl₃) δ 3.03(s, 6H), 3.48(s, 3H), 3.77(s, 3H), 5.15(s, 2H), 5.71(s, 1H), 6.73(dd, J=8.7&1.8Hz, 1H), 6.82(d, J=8.4Hz, 2H), 6.97 (d, J=1.8Hz, 1H), 6.98(dJ=8.7Hz, 1H), 7.11(s, 1H), 7.33–7.48(m, 5H), 7.56(d, J=8.7Hz, 2H), 9.92(s, 1H) IR(KBr)3524, 3447, 1697, 1612, 1586, 1525, 1468, 1364, 1283, 1257, 1230, 1201, 1127, 1103, 1073, 1020cm⁻¹ I-359 ¹HNMR(CDCl₃) δ 3.04(s, 6H), 3.14(s, 3H), 3.48(s, 3H), 3.76(s, 3H), 5.17(s, 2H), 6.84(d, J=8.7Hz, 2H), 7.06–7.17(m, 3H), 7.34(d, J=1.8Hz, 1H), 7.35–7.50(m, 6H), 7.55(d, J=8.7Hz, 2H), 10.08(s, 1H) IR(KBr)1698, 1610, 1527, 1470, 1357, 1290, 1232, 1183, 1115, 1083, 1018cm⁻¹ I-360 ¹HNMR(CDCl₃) δ 2.56(s, 3H), 3.02(s, 6H), 3.54(s, 3H), 3.76(s, 3H), 5.16(s, 2H), 5.67(s, 1H), 6.80(d, J=8.4Hz, 2H), 6.85(s, 1H), 6.91(d. d, J=8.4&2.1Hz, 1H), 7.01(d, J=8.4Hz, 1H), 7.05(d, J=2.1Hz, 1H), 7.30–7.47(m, 5H), 7.55(d, J=8.7Hz, 2H) IR(KBr)3542, 3436, 1605, 1530, 1483, 1391, 1360, 1287, 1253, 1234, 1169, 1074, 1016cm⁻¹ I-361 ¹HNMR(CDCl₃) δ 1.31(d, J=6.9Hz, 6H), 2.57(s, 3H), 2.97(quint, J=6.9Hz, 1H), 3.54(s, 3H), 3.76(s, 3H), 5.17(s, 2H), 5.68(s, 1H), 6.86( s, 1H), 6.92(dd, J=8.4&2.1Hz, 1H), 7.02(d, J=8.4Hz, 1H), 7.05(d, J=2.1Hz, 1H), 7.31(d, J=8.1Hz, 2H), 7.34–7.46(m, 5H), 7.55(d, J=8.1Hz, 2H) IR(KBr)3446, 1606, 1585, 1522, 1484, 1457, 1394, 1356, 1289, 1257, 1228, 1172, 1076, 1018, 1007cm⁻¹

TABLE 75 I-362 ¹HNMR(CDCl₃) δ 1.31(d, J=6.9Hz, 6H), 2.98(quint, J=6.9Hz, 1H), 3.46(s, 3H), 3.74(s, 3H), 5.15(s, 2H), 5.67(s, 1H), 5.92(s, 1H), 6.48 (s, 1H), 6.97(dd, J=8.4&1.8Hz, 1H), 7.03(d, J=8.4Hz, 1H), 7.10(d, J=1.8Hz, 1H), 7.25(s, 1H), 7.31(d, J=7.8Hz, 2H), 7.34–7.49(m, 5H), 7.57 (d, J=7.8Hz, 2H) IR(KBr)3538, 3505, 3465, 1610, 1586, 1552, 1518, 1584, 1458, 1398, 1281, 1288, 1245, 1198, 1112, 1071, 1002cm⁻¹ I-363 ¹HNMR(CDCl₃) δ 2.66(s, 3H), 3.06(s, 3H), 3.13(s, 3H), 3.57(s, 3H), 3.67(s, 3H), 3.78(s, 3H), 5.19(s, 2H), 6.44(s 1H), 6.85(s, 1H), 7.15 (d, J=8.7Hz, 1H), 7.28–7.51(m, 10H) IR(KBr)3443, 1604, 1518, 1479, 1364, 1237, 1177, 1153, 1118, 1078, 1014cm⁻¹ I-364 ¹HNMR(CDCl₃) δ 1.77(s, 3H), 1.81(s, 3H), 2.70(s, 3H), 3.06(s, 3H), 3.24(s, 3H), 3.58(s, 3H), 3.78(s, 3H), 4.64(d, J=6.6Hz, 2H), 5.49(t, J= 6.6Hz, 1H), 6.42(s, 1H), 6.85(s, 1H), 7.09(d, J=8.4Hz, 1H), 7.28–7.49(m, 5H) IR(KBr)3432, 3285, 1604, 1518, 1479, 1364, 1328, 1291, 1269, 1237, 1177, 1154, 1117, 1078cm⁻¹ I-365 ¹HNMR(CDCl₃) δ 1.57(s, 3H), 1.67(s, 3H), 1.77(s, 3H), 1.81(s, 3H), 2.70(s, 3H), 2.96(s, 3H), 3.24(s, 3H), 3.53(s, 3H), 3.78(s, 3H), 4.32 (d, J=7.2Hz, 2H), 4.64(d, J=6.9Hz, 2H), 5.25(t, J=6.9Hz, 1H), 5.49(t, J=7.2Hz, 1H), 6.85(s, 1H), 7.09(d, J=8.7Hz, 1H), 7.31–7.41(m, 3H), 7.44–7.64(m, 3H) IR(KBr)3433, 1600, 1517, 1474, 1365, 1339, 1237, 1178, 1153, 1118, 1078, 1014cm⁻¹ I-366 ¹HNMR(CDCl₃) δ 1.76(s, 3H), 1.82(s, 3H), 3.08(s, 3H), 348(s, 3H), 3.75(s, 311), 4.62(d, J=7.2Hz, 2H), 5.54(t, J=7.2Hz, 1H), 5.70(s, 1H), 5.85(s, 1H), 6.40(s, 1H), 6.46(s, 1H), 6.89–7.00(m, 2H), 7.05(d, J=1.5Hz, 1H), 7.43–7.51(m, 3H) IR(KBr)3437, 1605, 1585, 1518, 1482, 1386, 1323, 1243, 1152, 1114, 1071, 1002cm⁻¹ I-367 ¹HNMR(CDCl₃) δ 2.37(s, 3H), 3.21(s, 3H), 3.47(s, 3H), 3.64(s, 3H), 3.77(s, 3H), 3.84(s, 3H), 5.17(s, 2H), 6.63(s, 1H), 6.78(s, 1H), 7.10(s, 1H), 7.20(d, J=8.1Hz, 2H), 7.40(d, J=8.1Hz, 2H), 7.41(d, J=9.3Hz, 2H), 7.70(d, J=9.3Hz, 2H) IR(KBr)1702, 1607, 1589, 1518, 1468, 1356, 1216, 1151, 1067, 1039, 1018cm⁻¹

TABLE 76 I-368 ¹HNMR(CDCl₃) δ 2.37(s, 3H), 3.21(s, 3H), 3.48(s, 6H), 3.65(s, 3H), 3.73(s, 3H), 3.83(s, 3H), 4.32(d, J=11.4Hz, 1H), 4.51(d, J=11.4Hz, 1H), 5.17(s, 2H), 6.93(s, 1H), 6.71(s, 1H), 6.88(s, 1H), 7.21(d, J=8.4Hz, 2H), 7.32–7.41(m, 4H), 7.73(d, J=8.4Hz, 2H) IR(KBr)3514, 1608, 1516, 1465, 1355, 1215, 1149, 1076, 1039, 1017cm⁻¹ I-369 m.p. 125–127° C. ¹HNMR(CDCl₃) δ 2.60(s, 3H), 3.52(s, 3H), 3.73(s, 3H), 3.84(s, 3H), 5.20(s, 2H), 6.83(s, 1H), 7.00–7.48(m, 12H) IR(KBr)3434, 2943, 1611, 1580, 1520, 1498, 1480, 1398, 1297, 1268, 1245, 1179, 1129, 1079, 1009cm⁻¹ I-370 m.p. 137–139° C. ¹HNMR(CDCl₃) δ 3.43(s, 3H), 3.71(s, 3H), 3.85(s, 3H), 5.19(s, 2H), 5.92(s, 1H), 6.43(s, 1H), 7.01–7.51(m, 12H) IR(KBr)3391, 2937, 1615, 1583, 1520, 1503, 1482, 1464, 1405, 1359, 1314, 1292, 1273, 1239, 1121, 1108, 1069, 1005cm⁻¹ I-371 m.p. 92–94° C. ¹HNMR(CDCl₃) δ 1.76(s, 3H), 1.81(s, 3H), 2.70(s, 3H), 3.53(s, 3H), 3.73(s, 3H), 3.84(s, 3H), 4.63(d, J=6.9Hz, 2H), 5.53(m, 1H), 6.84(s, 1H), 7.00–7.45 (m, 7H) IR(KBr)3433, 2938, 1609, 1581, 1523, 1499, 1480, 1401, 1368, 1297, 1268, 1240, 1178, 1118, 1079, 1021cm⁻¹ I-372 foam ¹HNMR(CDCl₃) δ 1.68(s, 3H), 1.74(d, J=0.6Hz, 3H), 2.50–2.59(m, 2H), 2.71(s, 3H), 3.53(s, 3H), 3.73(s, 3H), 3.84(s, 3H), 4.04(t, J=7.2Hz, 2H), 5.23(m, 1H), 6.83(s, 1H), 7.00–7.42(m, 7H) IR(CHCl₃)3011, 2938, 1612, 1581, 1522, 1500, 1480, 1465, 1398, 1370, 1301, 1268, 1238, 1209, 1176, 1119, 1081, 1017cm⁻¹ I-373 m.p. 95–98° C. ¹HNMR(CDCl₃) δ 1.76(s, 3H), 1.80(s, 3H), 3.43(s, 3H), 3.72(s, 3H), 3.85(s, 3H), 4.63(d, J=6.6Hz, 2H), 5.56(m, 1H), 5.92(s, 1H), 6.43(s, 1H), 7.01–7.42(m, 7H) IR(KBr)3318, 2937, 1612, 1598, 1500, 1485, 1464, 1450, 1361, 1298, 1275, 1240, 1104, 1072, 1011cm⁻¹

TABLE 77 I-374 m.p. 69–71° C. ¹HNMR(CDCl₃) δ 1.68(s, 3H), 1.74(d, J=0.6Hz, 3H), 2.50–2.60(m, 2H), 3.43(s, 3H), 3.71(s, 3H), 3.85(s, 3H), 4.04(t, J=7.2Hz, 2H), 5.23(m, 1H), 5.91(s, 1H), 6.43(s, 1H), 7.00–7.42(m, 7H) IR(KBr)3385, 2933, 1611, 1583, 1521, 1503, 1485, 1466, 1403, 1358, 1299, 1276, 1241, 1122, 1104, 1071, 1011cm⁻¹ I-375 m.p. 105–107° C. ¹HNMR(CDCl₃) δ 2.36(s, 3H), 2.59(s, 3H), 3.52(s, 3H), 3.73(s, 3H), 3.84(s, 3H), 5.16(s, 2H), 6.83(s, 1H), 7.00–7.42(m, 11H) IR(KBr)3433, 2940, 1609, 1581, 1522, 1499, 1481, 1461, 1401, 1366, 1296, 1269, 1240, 1178, 1117, 1079, 1021, 1011cm⁻¹ I-376 m.p. 142–144° C. ¹HNMR(CDCl₃) δ 2.37(s, 3H), 3.42(s, 3H), 3.71(s, 3H), 3.85(s, 3H), 5.14(s, 2H), 5.91(s, 1H), 6.43(s, 1H), 7.01–7.42(m, 11H) IR(KBr)3367, 2936, 1615, 1583, 1520, 1502, 1482, 1464, 1447, 1405, 1359, 1317, 1291, 1274, 1239, 1121, 1109, 1070, 1009cm⁻¹ I-377 m.p. 174–176° C. ¹HNMR(CDCl₃) δ 3.21(s, 3H), 3.41(s, 3H), 3.63(s, 3H), 3.77(s, 3H), 5.30(s, 2H), 6.94(s, 1H), 7.03–7.05(m, 2H), 7.15–7.20(m, 1H), 7.25 (m, 1H), 7.38(d, J=8.9Hz, 2H), 7.62(d, J=7.8Hz, 1H), 7.71(d, J=8.9Hz, 2H), 7.76(dt, J=7.8, 1.5Hz, 1H), 8.60(m, 1H) IR(KBr)1732, 1523, 1474, 1368, 1148, 1061, 863, 845, 790cm⁻¹ I-378 m.p. >260° C. ¹HNMR(DMSO-d₆) δ 3.32(s, 3H), 3.73(s, 3H), 5.28(s, 2H), 6.87(d, J=8.7Hz, 2H), 7.00(s, 1H), 7.04(dd, J=8.9, 1.8Hz, 1H), 7.16(dd, J=12.3, 1.8Hz, 1H), 7.26(t, J=8.9Hz, 1H), 7.39(m, 1H), 7.57(d, J=8.7Hz, 2H), 7.58(d, J=7.8Hz, 1H), 7.89(dt, J=7.8, 1.5Hz, 1H), 8.61(m, 1H), 9.61(s, 1H), 12.9(brs, 1H) IR(KBr)3383, 1735, 1705, 1610, 1522, 1471, 1272, 1226, 1059, 1014, 838, 762cm⁻¹ I-379 m.p. 137–138° C. ¹HNMR(CDCl₃) δ 1.77(s, 3H), 1.82(s, 3H), 3.46(s, 3H), 3.79(s, 3H), 4.64(d, J=4.6Hz, 1H), 5.56(t, J=4.6Hz, 1H), 6.92–7.20(m, 6H), 7.61 (dd, J=3.6, 5.8Hz, 2H), 9.96(Brs, 1H) IR(KBr)3434, 2966, 2935, 2839, 1702, 1695, 1521, 1466, 1378, 1299, 1287, 1272, 1240, 1012, 840cm⁻¹

TABLE 78 I-380 m.p. 98–99° C. ¹HNMR(CDCl₃) δ 2.37(s, 3H), 3.45(s, 3H), 3.78(s, 3H), 5.15(s, 2H), 6.93–7.26(m, 4H), 7.36(d, J=7.8Hz, 2H), 7.62(dd, J=4.0, 8.8Hz, 2H), 9.94(s, 1H) IR(KBr)3446, 2933, 2845, 1699, 1521, 1473, 1463, 1381, 1293, 1261, 1238, 1221, 1131, 803cm⁻¹ I-381 m.p. 118–119° C. ¹HNMR(CDCl₃) δ 1.69(s, 3H), 1.74(s, 3H), 2.54(dt, J=5.0, 7.8Hz, 2H), 3.45(s, 3H), 3.78(s, 3H), 4.05(t, J=7.2Hz, 2H), 5.24(t, J=4.4Hz, 1H), 6.95–7.16(m, 6H), 7.61(dd, J=3.4, 8.8Hz, 2H), 9.95(brs, 1H) IR(KBr)3433, 2959, 2930, 2842, 1701, 1602, 1522, 1464, 1379, 1303, 1263, 1222, 1132, 1018cm⁻¹ I-382 m.p. 93–94° C. ¹HNMR(DMSO-d₆) δ 1.74(s, 3H), 1.78(s, 3H), 3.32(s, 3H), 3.71(s, 3H), 4.62(d, J=7.0Hz, 2H), 5.48(t, J=5.8Hz, 1H), 6.91(s, 1H), 7.09–7.35 (m, 2H), 7.64–7.71(m, 2H) IR(KBr)3433, 2976, 2937, 1707, 1604, 1520, 1472, 1376, 1300, 1265, 1226, 1160, 1131, 1060, 839cm⁻¹ I-383 m.p. 98–99° C. ¹HNMR(DMSO-d₆) δ 2.32(s, 3H), 3.31(s, 3H), 3.70(s, 3H), 5.13(s, 2H), 6.88(s, 1H), 7.14–7.39(m, 5H), 7.63–7.70(m, 2H) IR(KBr)3433, 2981, 2937, 1704, 1603, 1520, 1470, 1375, 1301, 1266, 1226, 1159, 1061, 839cm⁻¹ I-384 oil ¹HNMR(DMSO-d₆) δ 1.68(s, 3H), 1.74(s, 3H), 2.48–2.56(m, 2H), 3.57(s, 3H), 3.77(s, 3H), 3.98(t, J=4.8Hz, 2H), 5.26(t, J=4.2Hz, 1H), 6.84(s, 1H), 7.05–7.36(m, 5H), 7.63–7.70(m, 2H) IR(KBr)3433, 2979, 2938, 1726, 1603, 1522, 1470, 1376, 1301, 1264, 1226, 1160, 1132, 1080, 1058, 840cm⁻¹ I-385 m.p. 137–138° C. ¹HNMR(CDCl₃) δ 1.77(s, 3H), 1.82(s, 3H), 2.55(s, 3H), 3.21(s, 3H), 3.57(s, 3H), 3.78(s, 3H), 4.56(d, J=7.0Hz, 2H), 5.52(t, J=7.4Hz, 1H), 6.84(s, 1H), 7.02(d, J=8.8Hz, 2H), 7.34–7.40(m, 4H), 7.70(d, J=8.8Hz, 2H) IR(KBr)3434, 2938, 1607, 1519, 1366, 1244, 1174, 1151, 1072, 871, 796cm⁻¹

TABLE 79 I-386 m.p. 169–170° C. ¹HNMR(CDCl₃) δ 2.48(s, 3H), 3.21(s, 3H), 3.56(s, 3H), 3.77(s, 3H), 5.08(s, 2H), 6.84(s, 1H), 7.07(d, J=5.8Hz, 2H), 7.19–7.39(m, 4H), 7.70 (d, J=6.0Hz, 2H) IR(KBr)3432, 3016, 2935, 1605, 1519, 1479, 1368, 1357, 1233, 1176, 1151, 1076, 876, 843, 798cm⁻¹ I-387 m.p. 140–141° C. ¹HNMR(CDCl₃) δ 1.68(s, 3H), 1.75(s, 3H), 2.51(dt, J=4.4, 4.6Hz, 2H), 2.55(s, 3H), 3.21(s, 3H), 3.56(s, 3H), 3.77(s, 3H), 3.97(t, J=4.8Hz, 2H), 5.26(t, J=4.0Hz, 1H), 6.84(s, 1H), 6.99(d, J=5.8Hz, 2H), 7.34–7.39(m, 4H), 7.70(d, J=5.8Hz, 2H) IR(KBr)3445, 2937, 1608, 1519, 1480, 1391, 1361, 1351, 1237, 1177, 1154, 1077, 962, 871, 862, 800cm⁻¹ I-388 m.p. 124–125° C. ¹HNMR(DMSO-d₆) δ 1.73(s, 3H), 1.75(s, 3H), 3.30(s, 3H), 3.65(s, 3H), 4.54(d, J=6.6Hz, 2H), 5.47(t, J=6.4Hz, 1H), 6.40(s, 1H), 6.82–6.94 (m, 4H), 7.20(d, J=8.6Hz, 2H), 7.44(d, J=8.2Hz, 2H) IR(KBr)3411, 2934, 1608, 1523, 1487, 1396, 1231, 1175, 1105, 1072, 996, 898cm⁻¹ I-389 m.p. 93–94° C. ¹HNMR(DMSO-d₆) δ 2.32(s, 3H), 3.32(s, 3H), 3.64(s, 3H), 5.08(s, 2H), 6.40(s, 1H), 6.84(d, J=8.6Hz, 2H), 6.98(d, J=8.6Hz, 2H), 7.19–7.23 (m, 4H), 7.34–7.46(m, 4H) IR(KBr)3398, 2933., 1609, 1523, 1486, 1461, 1398, 1235, 1174, 1119, 1071, 997, 829cm⁻¹ I-390 oil ¹HNMR(DMSO-d₆) δ 1.72(s, 3H), 1.74(s, 3H), 2.52(dt, J=4.8, 5.0Hz, 2H), 3.24(s, 3H), 3.58(s, 3H), 4.06(t, J=7.2Hz, 2H), 5.24(t, J=4.4Hz, 1H), 6.80–6.95(m, 4H), 7.22(d, J=8.4Hz, 2H), 7.46(d, J=8.2Hz, 2H) IR(KBr)3340, 2934, 1608, 1522, 1486, 1396, 1285, 1230, 1175, 1106, 1072, 996, 828cm⁻¹ I-391 ¹HNMR(CDCl₃ + CD₃OD) δ 3.05(s, 3H), 3.48(s, 3H), 3.75(s, 3H), 5.16(s, 2H), 5.97(s, 1H), 6.02(s, 1H), 6.47(s, 1H), 6.94(d.d, J=8.4&1.8Hz, 1H), 7.04(d, J=8.4Hz, 1H), 7.07(d, J=1.8Hz, 1H), 7.22–7.52(m, 9H) IR(KBr)3548, 3357, 1603, 1589, 1520, 1487, 1460, 1445, 1410, 1329, 1286, 1247, 1153, 1115, 1077, 1010cm⁻¹

TABLE 80 I-392 ¹HNMR(CDCl₃) δ 2.37(s, 3H), 2.77–2.88(broad, 1H), 3.47(s, 3H), 3.64(s, 3H), 3.72(s, 3H), 3.82(s, 3H), 4.32(d.d, J=11.1&0.6Hz, 1H), 4.45–4.56(broad, 1H), 4.92(s, 1H), 5.16(s, 2H), 6.70(d, J=9.3Hz, 2H), 6.88(s, 1H), 6.92(d, J=9.0Hz, 2H), 7.22(d, J=8.4Hz, 2H), 738(d, J=8.4Hz, 2H), 7.56(d, J=9.0Hz, 2H) IR(KBr)3476, 1610, 1519, 1476, 1463, 1386, 1265, 1215, 1074, 1041, 1010cm⁻¹ I-393 foam ¹HNMR(CD₃OD) δ 2.34(s, 3H), 3.38(s, 3H), 3.68(s, 3H), 4.00(dd, J=9.9, 8.7Hz, 1H), 4.17(dd, J=9.9, 3.0Hz, 1H), 5.06(dd, J=8.7, 3.0Hz, 1H), 6.43(s, 1H), 6.78(dd, J=8.7, 1.8, 1H), 6.85(d, J=8.7Hz, 2H), 6.88(d, J=1.8Hz, 1H), 6.91(d, J=8.4Hz, 1H), 7.20(d, J=8.1Hz, 2H), 7.36 (d, J=8.1Hz, 2H), 7.46(d, J=8.7Hz, 2H) IR(Nujol)3367, 1655, 1612, 1586, 1523, 1489, 1459, 1254, 1225, 1115, 1072, 1015, 941, 817cm⁻¹ I-394 foam ¹HNMR(CD₃OD) δ 3.38(s, 3H), 3.67(s, 3H), 4.02(dd, J=10.2, 9.0Hz, 1H), 4.20(dd, J=10.2, 3.3Hz, 1H), 5.11(dd, J=9.0, 3.3Hz, 1H), 6.43 (s, 1H), 6.78(dd, J=8.4, 2.1, 1H), 6.85(d, J=8.7Hz, 2H), 6.88(d, J=2.1Hz, 1H), 6.91(d, J=8.4Hz, 1H), 7.46(d, J=8.7Hz, 2H), 7.30–7.50( m, 5H) IR(Nujol)3368, 1655, 1612, 1587, 1523, 1489, 1456, 1254, 1225, 1114, 1072, 1014, 941, 825, 764cm⁻¹ I-395 foam ¹HNMR(CDCl₃) δ 2.48(s, 3H), 2.82(s, 3H), 3.16(s, 3H), 3.22(s, 3H), 3.54(s, 3H), 3.77(s, 3H), 6.85(s, 3H), 7.34–7.38(m, 2H), 7.38(d, J=8.1Hz, 2H), 7.39(d, J=8.7Hz, 2H), 7.46(d, J=1.8Hz, 1H), 7.46(d, J=8.7Hz, 2H), 7.82(d, J=8.1Hz, 2H) IR(Nujol)1597, 1514, 1479, 1464, 1177, 1152, 1085, 969, 883, 846, 797, 729cm⁻¹ I-396 foam ¹HNMR(CDCl₃) δ 2.85(s, 3H), 3.14(s, 3H), 3.22(s, 3H), 3.54(s, 3H), 3.77(s, 3H), 6.85(s, 1H), 7.36(m, 2H), 7.39(d, J=8.7Hz, 2H), 7.45, ( m, 1H), 7.60(m, 2H), 7.66(d, J=8.7Hz, 2H), 7.74(m, 1H), 7.94(m, 2H) IR(Nujol)1612, 1584, 1514, 1479, 1451, 1179, 1152, 1085, 969, 949, 846, 797, 737cm⁻¹

TABLE 81 I-397 foam ¹HNMR(CDCl₃) δ 2.73(s, 3H), 3.21(s, 6H), 3.55(s, 3H), 3.77(s, 3H), 5.20(s, 2H), 6.84(s, 1H), 7.16(brs, 1H), 7.22(d, J=8.1Hz, 1H), 7.33, (d, J=2.4Hz, 1H), 7.37(brs, 2H), 7.38(d, J=8.7Hz, 2H), 7.65(brs, 1H), 7.67(d, J=8.7Hz, 2H) IR(Nujol)1608, 1519, 1480, 1464, 1176, 1151, 1080, 972, 876, 846, 798cm⁻¹ I-398 foam ¹HNMR(CDCl₃) δ 2.91(s, 3H), 3.19(s, 3H), 3.22(s, 3H), 3.54(s, 3H), 3.78(s, 3H), 5.26(s, 2H), 5.34(s, 2H), 7.04(brs, 1H), 7.05(s, 2H), 7.12 (brs, 1H), 7.39(d, J=8.7Hz, 2H), 7.36–7.43(m, 3H), 7.67(d, J=8.7Hz, 2H) IR(Nujol)1608, 1519, 1480, 1463, 1176, 1151, 1079, 972, 876, 799cm⁻¹ I-399 m.p. 203–205° C. ¹HNMR(DMSO-d₆) δ 2.87(s, 3H), 3.35(s, 3H), 3.45(s, 3H), 3.52(s, 3H), 3.78(s, 3H), 5.39(s, 2H), 7.07(s, 1H), 7.08(d, J=3.9Hz, 1H), 7.16 (d, J=3.9Hz, 1H), 7.31(dd, J=9.0, 1.8Hz, 1H), 7.33(s, 1H), 7.42(d, J=9.0Hz, 1H), 7.49(d, J=8.7Hz, 2H), 7.74(d, J=8.7Hz, 2H) IR(Nujol)1609, 1520, 1481, 1455, 1231, 1080, 1013, 984, 947, 878, 832, 798cm⁻¹ I-400 foam ¹HNMR(CDCl₃) δ 2.72(s, 3H), 3.14(s, 3H), 3.21(s, 3H), 3.55(s, 3H), 3.77(s, 3H), 5.14(s, 2H), 6.84(s, 1H), 7.11(d, J=8.7Hz, 1H), 7.34(dd, J=2.1, 8.7Hz, 1H), 7.34(d, J=8.4Hz, 2H), 7.37(d, J=8.4Hz, 2H), 7.41(d, J=2.1Hz, 1H), 7.54(d, J=8.4Hz, 2H), 7.68(d, J=8.4Hz, 2H) I-401 foam ¹HNMR(CDCl₃) δ 2.83(s, 3H), 3.14(s, 3H), 3.22(s, 3H), 3.55(s, 3H), 3.78(s, 3H), 5.26(s, 2H), 6.85(s, 1H), 7.24(d, J=8.4Hz, 1H), 7.38(d, J=8.4Hz, 1H), 7.41(dd, J=2.1, 8.4Hz, 1H), 7.44(d, J=2.1Hz, 1H), 7.67(d, J=8.4Hz, 2H) IR(KBr)1609, 1523, 1509, 1481, 1367, 1402, 1178, 1152, 1080, 973, 943, 876, 798cm⁻¹

TABLE 82 I-402 foam ¹HNMR(CDCl₃) δ 2.68(s, 3H), 3.14(s, 3H), 3.21(s, 3H), 3.55(s, 3H), 3.66(s, 2H), 3.71(s, 3H), 3.78(s, 3H), 5.18(s, 2H), 6.84(s, 1H), 7.14( d, J=8.4Hz, 1H), 7.32(d, J=8.7Hz, 1H), 7.35(dd, J=2.1, 8.7Hz, 1H), 7.37(d, J=8.4Hz, 2H), 7.39(d, J=2.1Hz, 1H), 7.42(d, J=8.4Hz, 2H), 7.67 (d, J=8.4Hz, 2H) IR(KBr)1736, 1610, 1519, 1481, 1365, 1177, 1151, 1079, 876, 817, 798cm⁻¹ I-403 foam ¹HNMR(CDCl₃) δ 2.70(s, 3H), 3.16(s, 3H), 3.21(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 5.24(s, 2H), 6.84(s, 1H), 7.18(d, J=8.4Hz, 1H), 7.36(dd, J=1.5, 8.4Hz, 1H), 7.38(d, J=8.4Hz, 2H), 7.41(d, J=1.5Hz, 1H), 7.46(m, 2H), 7.54(d, J=8.1Hz, 2H), 7.62(m, 3H), 7.64(d, J=8.1Hz, 2H), 7.68(d, J=8.4Hz, 2H) IR(KBr)1609, 1519, 1481, 1365, 1177, 1151, 1079, 1014, 876, 818, 797cm⁻¹ I-404 m.p. 128–130° C. ¹HNMR(CDCl₃) δ 2.75(s, 3H), 2.92(s, 3H), 3.18(t, J=6.9Hz, 2H), 3.21(s, 3H), 3.55(s, 3H), 3.77(s, 3H), 4.34(t, J=6.9Hz, 2H), 6.81(s, 1H), 7.08(d, J=8.4Hz, 1H), 7.29(m, 2H), 7.32(br.s, 3H), 7.35(dd, J=2.1, 8.4Hz, 1H), 7.38(d, J=8.4Hz, 2H), 7.39(d, J=2.1Hz, 1H), 7.67(d, J=8.4Hz, 2H) IR(KBr)1609, 1520, 1481, 1364, 1177, 1151, 1080, 872, 815, 797cm⁻¹ I-405 foam ¹HNMR(CDCl₃) δ 1.71(d, J=6.3Hz, 3H), 2.45(br.s, 3H), 3.20(s, 3H), 3.28(s, 3H), 3.53(s, 3H), 3.75(s, 3H), 5.43(q, J=6.3Hz, 1H), 6.81(s, 1H), 6.90(d, J=8.4Hz, 1H), 7.16(dd, J=2.1, 8.4Hz, 1H), 7.30(m, 1H), 7.36(d, J=2.1Hz, 1H), 7.37(d, J=8.4Hz, 2H), 7.35–7.41(m, 4H), 7.66 (d, J=8.4Hz, 2H) IR(KBr)1609, 1518, 1480, 1365, 1177, 1151, 1078, 874, 818, 798cm⁻¹

TABLE 83 I-406 foam ¹HNMR(CDCl₃) δ 1.02(t, J=9.0Hz, 3H), 2.04(dq, J=6.3, 9.0Hz, 2H), 2.39(br.s, 3H), 3.20(s, 3H), 3.30(s, 3H), 3.53(s, 3H), 3.75(s, 3H), 5.18 (t, J=6.3Hz, 1H), 6.80(s, 1H), 6.88(d, J=8.4Hz, 1H), 6.92(m, 1H), 7.14(dd, J=2.4, 8.4Hz, 1H), 7.25–7.40(m, 7H), 7.66(d, J=8.4Hz, 2H) IR(KBr)1609, 1518, 1480, 1365, 1177, 1151, 1079, 874, 819, 797cm⁻¹ I-407 foam ¹HNMR(CDCl₃) δ 2.46(s, 3H), 3.07(s, 3H), 3.20(s, 3H), 3.54(s, 3H), 3.76(s, 3H), 6.33(s, 1H), 6.82(s, 1H), 6.99(d, J=9.0Hz, 1H), 7.19(dd, J=2.1, 9.0Hz, 1H), 7.26–7.40(m, 9H), 7.43–7.47(m, 4H), 7.66(d, J=8.4Hz, 2H) IR(KBr)1607, 1518, 1481, 1364, 1177, 1151, 1081, 873, 822, 798cm⁻¹ I-408 m.p. 179–180 ° C. ¹HNMR(CDCl₃) δ 1.69(d, J=6.3Hz, 3H), 2..34(br.s, 3H), 2.45(s, 3H), 3.20(s, 3H), 3.27(s, 3H), 3.54(s, 3H), 3.75(s, 3H), 5.40(q, J=6.3Hz, 1H), 6.81(s, 1H), 6.92(d, J=8.7Hz, 1H), 7.15(d, J=8.7Hz, 2H), 7.16(dd, J=2.1, 8.4Hz, 1H), 7.27(d, J=8.7Hz, 1H), 7.35(d, J=2.1Hz, 1H), 7.37(d, J=8.4Hz, 2H), 7.66(d, J=8.4Hz, 2H) IR(KBr)1609, 1518, 1480, 1365, 1177, 1151, 1078, 874, 819, 797cm⁻¹ I-409 m.p. 243–244° C. ¹HNMR(DMSO-d₆) δ 3.30(s, 3H), 3.64(s, 3H), 5.19(s, 2H), 6.39(s, 1H), 6.64(dd, J=1.8, 8.4Hz, 1H), 6.77(d, J=1.8Hz, 1H), 6.83(d, J=8.4Hz, 2H), 6.97(d, J=8.4Hz, 1H), 7.37(t, J=7.5Hz, 1H), 7.44(d, J=8.4Hz, 2H), 7.48(t, J=8.4Hz, 2H), 7.60(d, J=8.4Hz, 2H), 7.67–7.73(m, 5H) IR(KBr)3421, 1610, 1523, 1488, 1463, 1403, 1176, 1115, 1072, 821cm⁻¹ I-410 foam ¹HNMR(CDCl₃) δ 3.18(t, J=6.9Hz, 2H), 3.45(s, 3H), 3.73(s, 3H), 4.31(t, J=6.9Hz, 2H), 6.44(s, 1H), 6.91(d, J=8.4Hz, 2H), 6.94(br.s, 2H), 7.03(br.s, 1H), 7.23–7.37(m, 5H), 7.53(d, J=8.4Hz, 2H) IR(KBr)3434, 1612, 1587, 1523, 1489, 1455, 1403, 1250, 1113, 1070, 1011, 825, 815cm⁻¹

TABLE 84 I-411 foam ¹HNMR(CDCl₃) δ 1.70(d, J=6.0Hz, 3H), 3.44(s, 3H), 3.72(s, 3H), 5.36(q, J=6.0Hz, 1H), 6.42(s, 1H), 6.78(d, J=8.1Hz, 1H), 6.81(dd, J=1.5, 8.7Hz, 1H), 6.91(d, J=8.4Hz, 2H), 7.06(d, J=1.5Hz, 1H), 7.26–7.42(m, 4H), 7.51(d, J=8.4Hz, 2H) IR(KBr)3472, 1612, 1587, 1523, 1488, 1454, 1403, 1248, 1113, 1070, 1011, 825,cm⁻¹ I-412 foam ¹HNMR(CDCl₃) δ 1.03(t, J=7.2Hz, 3H), 1.94(m, 1H), 2.06(m, 1H), 3.43(s, 3H), 3.72(s, 3H), 5.08(dd, J=7.2, 5.4Hz, 1H), 6.43(s, 1H), 6.73(d, J=8.4Hz, 1H), 6.78(dd, J=1.8, 8.4Hz, 1H), 6.90(d, J=8.4Hz, 2H), 7.05(d, J=1.8Hz, 1H), 7.25–7.38(m, 5H), 7.51(d, J=8.4Hz, 2H) IR(KBr)3434, 1612, 1522, 1488, 1454, 1403, 1247, 1113, 1070, 1011, 826, 811cm⁻¹ I-413 foam ¹HNMR(CDCl₃) δ 3.44(s, 3H), 3.73(s, 3H), 6.25(s, 1H), 6.43(s, 1H), 7.26(m, 2H), 6.90(d, J=8.4Hz, 2H), 7.08(d, J=2.1Hz, 1H), 7.29–7.43 (m, 10H), 7.51(d, J=8.4Hz, 2H) IR(KBr)3432, 1611, 1523, 1489, 1454, 1402, 1226, 1110, 1069, 1011, 825cm⁻¹ I-414 foam ¹HNMR(CDCl₃) δ 1.69(d, J=6.3Hz, 3H), 2..35(s, 3H), 3.44(s, 3H), 3.72(s, 3H), 5.33(q, J=6.3Hz, 1H), 6.42(s, 1H), 6.80(br.s, 2H), 6.90( d, J=8.4Hz, 2H), 7.05(br.s, 1H), 7.18(d, J=7.8Hz, 2H), 7.29(d, J=7.8Hz, 2H), 7.51(d, J=8.4Hz, 2H) IR(KBr)3433, 1612, 1522, 1488, 1459, 1403, 1248, 1113, 1069, 1011, 817cm⁻¹ I-415 m.p. 164–167° C. ¹HNMR(CDCl₃) δ 3.79(s, 3H), 3.80(s, 3H), 4.81(brs, 1H), 5.29(s, 2H), 6.88–6.94(m, 4H), 7.16(d, J=8.7Hz, 1H), 7.32–7.52(m, 7H), 7.73 (dd, J=2.1, 8.7Hz, 1H), 8.10(d, J=2.1Hz, 1H) IR(KBr)3513, 2930, 1618, 1529, 1497, 1448, 1387, 1354, 1296, 1257, 1211, 1168, 1091, 1064, 1024cm⁻¹

TABLE 85 I-416 m.p. 155–159° C. ¹HNMR(CDCl₃) δ 3.20(s, 3H), 3.39(s, 3H), 3.82(s, 3H), 3.83(s, 3H)6.95(s, 1H), 6.96(s, 1H), 7.34–7.38(m, 2H), 7.58–7.64(m, 3H), 7.87( dd, J=2.1, 8.4Hz, 1H), 8.26(d, J=2.1Hz, 1H) IR(KBr)3433, 2944, 1539, 1519, 1487, 1358, 1216, 1176, 1150, 1086, 1057, 1031cm⁻¹ I-417 m.p. 124–126° C. ¹HNMR(CDCl₃) δ 3.19(s, 3H), 3.80(s, 6H), 5.30(s, 2H), 6.93(s, 1H), 6.94(s, 1H), 7.18(d, J=9.0Hz, 1H), 7.32–7.52(m, 7H), 7.59–7.64(m, 2H), 7.73(dd, J=2.1, 9.0Hz, 1H), 8.10(d, J=2.1Hz, 1H) IR(KBr)3433, 2937, 1619, 1531, 1491, 1465, 1450, 1358, 1290, 1256, 1211, 1176, 1150, 1088, 1062, 1033cm⁻¹ I-418 m.p. 151–153° C. ¹HNMR(CDCl₃) δ 3.18(s, 3H), 3.781(s, 3H), 3.784(s, 3H), 5.14(s, 2H), 6.90–7.00(m, 5H), 7.31–7.50(m, 7H), 7.60–7.65(m, 2H) IR(KBr)3480, 3383, 2930, 1610, 1523, 1489, 1467, 1383, 1358, 1330, 1211, 1175, 1147, 1024cm⁻¹ I-419 m.p. 198–200° C. ¹HNMR(CDCl₃) δ 3.77(s, 6H), 5.13(s, 2H), 6.86–7.00(m, 7H)7.34–7.50(m, 7H) IR(KBr)3403, 3327, 1611, 1592, 1525, 1492, 1462, 1444, 1384, 1318, 1273, 1243, 1209, 1178, 1149, 1110, 1058, 1037, 1006cm⁻¹ I-420 m.p. 168–171° C. ¹HNMR(CDCl₃) δ 2.99(s, 3H), 3.19(s, 3H), 3.80(s, 3H), 3.81(s, 3H), 5.16(s, 2H), 6.83(brs, 1H), 6.92(s, 1H), 6.96(s, 1H), 7.06(d, J=8.7Hz, 1H), 7.32–7.46(m, 8H), 7.60–7.64(m, 2H), 7.81(d, J=2.1Hz, 1H) IR(KBr)3403, 3327, 1611, 1592, 1525, 1492, 1462, 1444, 1384, 1318, 1273, 1243, 1209, 1178, 1149, 1110, 1058, 1037, 1006cm⁻¹ I-421 m.p. 168–171° C. ¹HNMR(CDCl₃) δ 3.19(s, 3H), 3.80(s, 3H), 3.81(s, 3H), 5.23(s, 2H), 6.93(s, 1H), 6.97(s, 1H), 7.07(d, J=8.7Hz, 1H), 7.33–7.45(m, 8H), 7.61–7.65(m, 2H), 8.58(d, J=2.4Hz, 1H), 8.66(brs, 1H) IR(KBr)3401, 1723, 1613, 1595, 1549, 1518, 1486, 1385, 1365, 1330, 1299, 1256, 1212, 1151, 1119, 1060, 1037, 1017cm⁻¹

TABLE 86 I-422 m.p. 159–160° C. ¹HNMR(CDCl₃) δ 1.69(s, 3H), 1.74, (s, 3H), 2.55(q, J=7.2Hz, 2H), 2.73(s, 3H), 3.22(s, 3H), 3.55(s, 3H), 3.77(s, 3H), 4.06(t, J=7.2Hz, 2H), 5.24(t, J=7.2Hz, 1H), 6.85(s, 1H), 7.07(d, J=8.6Hz, 1H), 7.39(d, J=8.7Hz, 2H), 7.55(dd, J=8.6, 2.1Hz, 1H), 7.63(d, J=2.1Hz, 1H), 7.68 (d, J=8.7Hz, 2H) IR(KBr)1515, 1481, 1359, 1325, 1175, 1140, 1079, 870, 799cm⁻¹ I-423 m.p. 180–182° C. ¹HNMR(CDCl₃) δ 1.76(s, 3H), 1.81, (s, 3H), 2.71(s, 3H), 3.22(s, 3H), 3.55(s, 3H), 3.78(s, 3H), 4.06(d, J=6.3Hz, 2H), 5.50(t, J=6.3Hz, 1H), 6.85(s, 1H), 7.09(d, J=8.7Hz, 1H), 7.39(d, J=8.7Hz, 2H), 7.55(dd, J=8.7, 2.0Hz, 1H), 7.64(d, J=2.0Hz, 1H), 7.68(d, J=8.7Hz, 2H) IR(KBr)1514, 1479, 1360, 1241, 1174, 1132, 1078, 866, 800cm⁻¹ I-424 m.p. 176–178° C. ¹HNMR(CDCl₃) δ 2.64(s, 3H), 3.22(s, 3H), 3.55(s, 3H), 3.78(s, 3H), 5.26(s, 2H), 6.85(s, 1H), 7.14(d, J=8.6Hz, 1H), 7.33–7.48(m, 7H), 7.54 (dd, J=8.6, 2.1Hz, 1H), 7.66–7.70(m, 3H) IR(KBr)1517, 1482, 1367, 1327, 1178, 1150, 1135, 1081, 878, 797cm⁻¹ I-425 m.p. 199–200° C. ¹HNMR(CDCl₃) δ 2.37(s, 3H), 2.63(s, 3H), 3.21(s, 3H), 3.55(s, 3H), 3.78(s, 3H), 5.21(s, 2H), 6.84(s, 1H), 7. 13(d, J=8.7Hz, 1H), 7.20(d, J=8.0Hz, 2H), 7.34(d, J=8.0Hz, 2H), 7.38(d, J=9.0Hz, 2H), 7.53(dd, J=8.7, 1.8Hz, 1H), 7.66(d, J=1.8Hz, 1H), 7.68(d, J=9.0Hz, 2H) IR(KBr)1517, 1481, 1366, 1326, 1255, 1177, 1151, 1082, 871, 798cm⁻¹ I-426 amorphous ¹HNMR(CDCl₃) δ 1.68(s, 3H), 1.73(s, 3H), 2.54(q, J=7.2Hz, 2H), 3.44(s, 3H), 3.75(s, 3H), 4.05(t, J=7.2Hz, 2H), 5.07(s, 1H), 5.24(t, J=7.2Hz, 1H), 6.02(s, 1H), 6.45(s, 1H), 6.92(d, J=8.6Hz, 2H), 7.41(d, J=8.6Hz, 1H), 7.53(d, J=8.6Hz, 2H), 7.59(dd, J=8.6, 2.0Hz, 1H), 7.63 (d, J=2.0Hz, 1H) IR(CHCl₃)3595, 3506, 1614, 1523, 1489, 1326, 1281, 1258, 1122, 1079, 1057cm⁻¹

TABLE 87 I-427 m.p. 180–182° C. ¹HNMR(CDCl₃) δ 1.75(s, 3H), 1.80(s, 3H), 3.44(s, 3H), 3.76(s, 3H), 4.66(d, J=6.6Hz, 2H), 4.87(s, 1H), 5.52(t, J=6.6Hz, 1H), 6.02(s, 1H), 6.46(s, 1H), 6.93(d, J=8.9Hz, 2H), 7.06(d, J=8.4Hz, 1H), 7.53(d, J=8.9Hz, 2H), 7.59(dd, J=8.4, 2.1Hz, 1H), 7.71(d, J=2.1Hz, 1H), IR(KBr)3406, 1615, 1522, 1488, 1399, 1324, 1280, 1256, 1138, 1116, 1076, 1054, 996, 835, 826cm⁻¹ I-428 m.p. 133–135° C. ¹HNMR(CDCl₃) δ 3.44(s, 3H), 3.75(s, 3H), 4.87(s, 1H), 5.23(s, 2H), 6.03(s, 1H), 6.46(s, 1H), 6.93(d, J=8.6Hz, 2H), 7.11(d, J=8.4Hz, 1H), 7.32–7.49(m, 5H), 7.53(d, J=8.6Hz, 2H), 7.60(dd, J=8.4, 2.1Hz, 1H), 7.75(d, J=2.1Hz, 1H), IR(KBr)3397, 1612, 1523, 1489, 1400, 1321, 1257, 1132, 1084, 1056, 1002, 832cm⁻¹ I-429 m.p. 174–176° C. ¹HNMR(CDCl₃) δ 2.37(s, 3H), 3.44(s, 3H), 3.75(s, 3H), 4.88(s, 1H), 5.18(s, 2H), 6.02(s, 1H), 6.45(s, 1H), 6.93(d, J=8.6Hz, 2H), 7.11(d, J=8.4Hz, 1H), 7.21(d, J=8.1Hz, 2H), 7.36(d, J=8.1Hz, 2H), 7.53(d, J=8.6Hz, 2H), 7.59(dd, J=8.4, 2.1Hz, 1H), 7.74(d, J=2.1Hz, 1H), IR(KBr)3481, 3376, 1616, 1520, 1491, 1327, 1260, 1119, 1081, 1004, 827cm⁻¹ I-430 ¹HNMR(CDCl₃) δ 2.37(s, 3H), 2.54(s, 3H), 2.68(s, 3H), 3.12(s, 3H), 3.54(s, 3H), 3.77(s, 3H), 5.14(s, 2H), 6.85(s, 1H), 7.12–7.24(m, 3H), 7.30–7.44(m, 6H), 7.53–7.59(m, 2H) IR(CHCl₃)1608, 1517, 1476, 1367, 1117, 1080, 1013, 970, 876cm⁻¹ I-431 m.p. 164–168° C. ¹HNMR(CDCl₃) δ 1.76(s, 3H), 1.82(s, 3H), 2.54(s, 3H), 3.47(s, 3H), 3.75(s, 3H), 4.62(d, J=6.9Hz, 2H), 5.53(m, 1H), 5.69(s, 1H), 5.89(s, 1H), 6.46(s, 1H), 6.92–7.08(m, 3H), 7.30–7.38(m, 2H), 7.55–7.62(m, 2H) IR(CHCl₃)3518, 2968, 1584, 1516, 1483, 1460, 1414, 1388, 1310, 1289, 1243, 1114, 1069, 1011, 936, 818cm⁻¹ I-432 m.p. 179–181° C. ¹HNMR(CDCl₃) δ 2.39(s, 3H), 2.54(s, 3H), 3.46(s, 3H), 3.74(s, 3H), 5.10(s, 2H), 5.67(s, 1H), 5.89(s, 1H), 6.46(s, 1H), 6.81(dd, J=2.1, 8.4Hz, 1H), 7.03(d, J=8.4Hz, 1H), 7.08(d, J=2.1Hz, 1H), 7.20–7.26(m, 2H), 7.31–7.37(m, 4H), 7.55–7.61(m, 2H) IR(CHCl₃)3524, 2930, 1585, 1517, 1483, 1460, 1414, 1389, 1310, 1289, 1245, 1114, 1090, 1070, 1009, 937, 818cm⁻¹

TABLE 88 I-433 m.p. 111–112° C. ¹HNMR(CDCl₃) δ 1.76(d, J=0.6Hz, 3H), 1.81(d, J=0.9Hz, 3H), 2.69(s, 3H), 3.52(s, 3H), 3.78(s, 3H), 4.63(t, J=6.6Hz, 2H), 5.53(m, 1H), 6.84(s, 1H), 7.02–7.25(m, 5H), 7.56–7.65(m, 2H) IR(CHCl₃)2932, 1607, 1520, 1481, 1368, 1266, 1080, 1012, 961, 907, 836, 812cm⁻¹ I-434 m.p. 97–101° C. ¹HNMR(CDCl₃) δ 1.69(s, 3H), 1.75(d, J=0.9Hz, 3H), 2.48–2.58(m, 5H), 3.46(s, 3H), 3.47(s, 3H), 4.06(t, J=6.9Hz, 2H), 5.22(m, 1H), 5.67 (s, 1H), 5.88(s, 1H), 6.46(s, 1H), 6.92–6.97(m, 2H), 7.05(m, 1H), 7.30–7.38(m, 2H), 7.55–7.62(m, 2H) IR(CHCl₃)3518, 2928, 1584, 1517, 1483, 1414, 1388, 1290, 1246, 1114, 1090, 1070, 1011, 937, 907, 818cm⁻¹ I-435 m.p. 127–129° C. ¹HNMR(CDCl₃) δ 1.68(s, 3H), 1.74(d, J=1.2Hz, 3H), 2.50–2.60(m, 2H), 2.71(s, 3H), 3.52(s, 3H), 3.77(s, 3H), 4.04(t, J=7.2Hz, 2H), 5.23 (m, 1H), 6.83(s, 1H), 7.00–7.21(m, 5H), 7.57–7.64(m, 2H) IR(CHCl₃)2930, 1607, 1520, 1481, 1368, 1266, 1080, 1012, 960, 836, 812cm⁻¹ I-436 m.p. 159–161° C. ¹HNMR(CDCl₃) δ 2.36(s, 3H), 2.57(s, 3H), 3.52(s, 3H), 3.77(s, 3H), 5.16(s, 2H), 6.83(s, 1H), 7.05–7.24(m, 7H), 7.31–7.37(m, 2H), 7.56–7.65 (m, 2H) IR(CHCl₃)1520, 1481, 1368, 1267, 1131, 1080, 1012, 960, 836cm⁻¹ I-437 m.p. 120–124° C. ¹HNMR(CDCl₃) δ 1.76(d, J=0.6Hz, 3H), 1.81(d, J=0.6Hz, 3H), 3.43(s, 3H), 3.67(s, 3H), 4.63(d, J=6.6Hz, 2H), 5.56(m, 1H), 5.96(s, 1H), 6.44(s, 1H), 7.00–7.24(m, 5H), 7.57–7.66(m, 2H) IR(CHCl₃)3522, 2930, 1586, 1518, 1484, 1415, 1390, 1311, 1290, 1248, 1115, 1090, 1071, 1012, 938, 818cm⁻¹

TABLE 89 I-438 m.p. 140.5–141.5° C. ¹HNMR(CDCl₃) δ 2.37(s, 3H), 3.43(s, 3H), 3.75(s, 3H), 5.14(s, 2H), 5.97(s, 1H), 6.44(s, 1H), 7.04–7.28(m, 7H), 7.36(d, J=8.1Hz, 1H), 7.57–7.65(m, 2H) IR(CHCl₃)3496, 2932, 1613, 1520, 1488, 1460, 1391, 1313, 1267, 1113, 1069, 1010, 934, 825cm⁻¹ I-439 m.p. 76.5–77.5° C. ¹HNMR(CDCl₃) δ 1.68(s, 3H), 1.74(d, J=0.9Hz, 3H), 2.49–2.60(m, 2H), 3.43(s, 3H), 3.75(s, 3H), 4.05(t, J=7.2Hz, 2H), 5.23(m, 1H), 5.96 (s, 1H), 6.44(s, 1H), 6.99–7.28(m, 5H), 7.57–7.66(m, 2H) IR(CHCl₃)3498, 2930, 1613, 1521, 1489, 1391, 1310, 1267, 1113, 1070, 1011, 934, 825cm⁻¹ I-440 m.p. 174–176° C. ¹HNMR(CDCl₃) δ 2.80(s, 3H), 3.46(s, 3H), 3.76(s, 3H), 5.16(s, 2H), 5.71(s, 1H), 5.88(s, 1H), 6.47(s, 1H), 6.95(dd, J=1.8, 8.4Hz, 1H), 7.04(d, J=8.4Hz, 1H), 7.08(d, J=1.8Hz, 1H), 7.34–7.49(m, 5H), 7.72–7.85(m, 4H) IR(CHCl₃)3518, 1587, 1516, 1483, 1459, 1415, 1387, 1290, 1114, 1070, 1041, 1011, 936, 821cm⁻¹ I-441 m.p. 199–202° C. ¹HNMR(d6-DMSO) δ 3.28(s, 3H), 3.34(s, 3H), 3.67(s, 3H), 5.14(s, 2H), 6.52(s, 1H), 6.66(dd, J=2.1, 8.4Hz, 1H), 6.79(d, J=2.1Hz, 1H), 6.97(d, J=8.4Hz, 1H), 7.30–7.56(m, 5H), 7.86–7.93(m, 2H), 7.98–8.04(m, 2H), 8.65–9.02(brs, 2H) IR(KBr)3487, 3413, 3004, 1597, 1518, 1500, 1482, 1456, 1360, 1310, 1281, 1231, 1146, 1118, 1090, 1068, 1016, 1004, 961cm⁻¹ I-442 m.p. 80–84° C. ¹HNMR(CDCl₃) δ 1.15(t, J=7.2Hz, 3H), 3.60(q, J=7.2Hz, 2H), 3.75(s, 3H), 5.03(s, 1H), 5.15(s, 2H), 5.69(s, 1H), 5.98(s, 1H), 6.45(s, 1H), 6.88–6.94(m, 2H), 6.96(dd, J=2.1, 8.1Hz, 1H), 7.02(d, J=8.1Hz, 1H), 7.10(d, J=2.1Hz, 1H), 7.34–7.49(m, 5H), 7.51–7.59(m, 2H) IR(CHCl₃)3528, 1612, 1521, 1488, 1454, 1412, 1383, 1286, 1246, 1113, 1069, 1023, 886, 825cm⁻¹

TABLE 90 I-443 m.p. 168–169° C. ¹HNMR(CDCl₃) δ 1.14(t, J=6.9Hz, 3H), 2.66(s, 3H), 3.13(s, 3H), 3.20(s, 3H), 3.72(q, J=6.9Hz, 2H), 3.78(s, 3H), 5.19(s, 2H), 6.84(s, 1H), 7.15(d, J=8.4Hz, 1H), 7.31–7.49(m, 9H), 7.66–7.73(m, 5H) IR(CHCl₃)1517, 1479, 1369, 1148, 1117, 1082, 969, 873cm⁻¹ I-444 m.p. 192–194° C. ¹HNMR(CDCl₃) δ 3.13(s, 3H), 3.44(s, 3H), 3.63(s, 3H), 3.76(s, 3H), 5.14(br, 1H), 5.19(s, 2H), 6.81–6.84(m, 2H), 6.94(s, 1H), 7.14(d, J=8.4Hz, 1H), 7.22–7.25(m, 2H), 7.37–7.50(m, 5H)7.57(dd, J=8.7, 2.1Hz, 1H), 7.67(d, J=2.1Hz, 1H) IR(CHCl₃)3595, 3441, 1730, 1613, 1522, 1472, 1371, 1291, 1258, 1172, 1164, 1003, 972, 961, 904, 838cm⁻¹ I-445 m.p. 179–180° C. ¹HNMR(CDCl₃) δ 1.77(s, 3H), 1.82(s, 3H), 2.31(s, 3H), 3.24(s, 3H), 3.45(s, 3H), 3.58(s, 3H), 3.76(s, 3H), 4.64(d, J=6.9Hz, 2H), 6.95(s, 1H), 7.06–7.13(m, 3H), 7.35–7.38(m, 2H), 7.57(dd, J=8.4, 2.4Hz, 1H), 7.64(d, J=2.4Hz, 1H) IR(CHCl₃)2938, 1732, 1614, 1599, 1518, 1470, 1445, 1370, 1345, 1290, 1228, 1200, 1169, 1116, 1081, 1003, 973, 905, 846, 829cm⁻¹ I-446 m.p. 137–138° C. ¹HNMR(CDCl₃) δ 3.13(s, 3H), 3.45(s, 3H), 3.59(s, 3H), 3.77(s, 3H), 3.88(s, 3H), 4.23(s, 2H), 5.19(s, 2H), 6.96(s, 1H), 7.15(d, J=8.7Hz, 1H), 7.35–7.50(m, 9H), 7.60(dd, J=8.7, 2.4Hz, 1H), 7.67(d, J=2.4Hz, 1H) IR(CHCl₃)2954, 1750, 1734, 1614, 1516, 1471, 1387, 1372, 1345, 1291, 1258, 1173, 1147, 1118, 1081, 1064, 1004, 877cm⁻¹ I-447 m.p. 184–185° C. ¹HNMR(CDCl₃) δ 3.44(s, 3H), 3.60(s, 3H), 3.74(s, 3H), 4.70(br, 2H), 5.17(s, 2H), 6.95–7.02(m, 4H), 7.17(dd, J=8.4, 2.1Hz, 1H), 7.25(s, 1H), 7.31–7.34(d, J=8.7Hz, 2H), 7.38–7.47(m, 5H) IR(CHCl₃)3541, 2937, 1776, 1733, 1608, 1519, 1474, 1442, 1344, 1291, 1157, 1130, 1085, 1063, 1002, 900, 862, 1835cm⁻¹

TABLE 91 I-448 m.p. 176–178° C. ¹HNMR(CDCl₃) δ 3.12(s, 3H), 3.44(s, 3H), 3.60(s, 3H), 3.76(s, 3H), 3.83(s, 3H), 4.66(s, 2H), 5.19(s, 2H), 6.91–6.96(m, 3H), 7.14(d, J=8.4Hz, 1H), 7.28–7.49(m, 7H), 7.57(dd, J=8.7, 2.4Hz, 1H), 7.67(d, J=2.4Hz, 1H) IR(CHCl₃)2953, 2939, 1758, 1732, 1610, 1519, 1471, 1444, 1371, 1345, 1291, 1177, 1117, 1085, 1064, 1002, 973, 961, 904, 837cm⁻¹ I-449 m.p. 124–126° C. ¹HNMR(CDCl₃) δ 1.69(s, 3H), 1.74(d, J=0.9Hz, 3H), 2.31(s, 3H), 2.53–2.60(m, 2H), 3.23(s, 3H), 3.44(s, 3H), 3.58(s, 3H), 3.76(s, 3H), 4.09 (t, J=6.6Hz, 2H), 5.22(m, 1H), 6.95(s, 1H), 7.07(d, J=8.4Hz, 1H), 7.10–7.13(m, 2H), 7.34–7.37(m, 2H), 7.57(dd, J=9.0, 2.4Hz, 1H), 7.6 4(d, J=2.4Hz, 1H) IR(CHCl₃)2938, 1732, 1614, 1518, 1469, 1445, 1370, 1291, 1257, 1170, 1167, 1081, 1004, 973, 961, 906, 846cm⁻¹ I-450 m.p. 160–161° C. ¹HNMR(CDCl₃) δ 1.69(s, 3H), 1.74(d, J=0.9, 3H), 2.53–2.60(m, 2H), 3.23(s, 3H), 3.44(s, 3H), 3.62(s, 3H), 3.76(s, 3H), 4.08(d, J=6.6Hz, 2H), 4.91(br, 1H), 5.20–5.25(m, 1H), 6.83–6.86(m, 2H), 6.94(s, 1H), 7.06(d, J=8.7Hz, 2H), 7.23–7.26(m, 2H), 7.57(dd, J=8.7, 2.4Hz, 1H), 7.64(d, J=2.4Hz, 1H) IR(CHCl₃)3595, 3448, 2937, 1730, 1613, 1522, 1469, 1445, 1370, 1345, 1292, 1260, 1172, 1117, 1081, 1064, 1003, 973, 864, 837cm⁻¹ I-451 m.p. 182–184° C. ¹HNMR(CDCl₃) δ 1.70(d, J=0.6Hz, 3H), 1.81(d, J=0.9Hz, 3H), 3.24(s, 3H), 3.45(s, 3H), 3.63(s, 3H), 3.75(s, 3H), 4.64(d, J=6.6Hz, 2H), 5.48–5.54(m, 1H), 5.76(br, 1H), 6.78–6.82(m,2H), 6.95(s, 1H), 7.08(d, J=8.7Hz, 1H), 7.19–7.24(m, 2H), 7.56(dd, J=8.7, 2.4Hz, 1H), 7.6 4(d, J=2.4Hz, 1H) IR(CHCl₃)3595, 3445, 2939, 1730, 1613, 1522, 1471, 1445, 1369, 1345, 1291, 1257, 1172, 1116, 1081, 1064, 1002, 973, 904, 838cm⁻¹ I-452 m.p. 250–253° C.(dec.) ¹HNMR(CD₃OD) δ 3.41(s, 3H), 3.71(s, 3H), 4.58(s, 2H), 5.21(s, 2H), 6.29–6.95(m, 3H), 7.02–7.03(m, 2H), 7.17(s, 1H), 7.26–7.41(m, 5H), 7.49–7.52(m, 2H) IR(KBr)3424, 2933, 2553, 1709, 1608, 1519, 1467, 1383, 1333, 1291, 1229, 1129, 1084, 1060, 1001, 915, 861, 841, 727, 697cm⁻¹

TABLE 92 I-453 foam ¹HNMR(CDCl₃) δ 1.69(s, 3H), 1.75(d, J=1.2Hz, 3H), 2.51–2.58(m, 2H), 3.43(s, 3H), 3.62(s, 3H), 3.75(s, 3H), 4.08(t, J=6.9Hz, 2H), 4.85(br, 1H), 5.23(m, 1H), 5.71(br, 1H), 6.82–6.85(m, 2H), 6.90–6.94(m, 2H), 7.16(dd, J=8.4, 2.1Hz, 1H), 7.23–7.26(m, 3H) IR(CHCl₃)3596, 3541, 2936, 1730, 1612, 1590, 1522, 1470, 1395, 1345, 1290, 1258, 1173, 1130, 1081, 1063, 1004, 861, 836cm⁻¹ I-454 m.p. 166–167° C. ¹HNMR(CDCl₃) δ 1.77(s, 3H), 1.82(s, 3H), 3.48(s, 3H), 3.75(s, 3H), 4.64(d, J=6.6Hz, 2H), 5.51–5.55(m, 1H), 5.75(br, 1H), 6.77– 6.80(m, 2H), 6.93–6.96(m, 2H), 7.17(dd, J=8.1, 2.1Hz, 1H), 7.23–7.28(m, 3H) IR(KBr)3447, 2937, 1590, 1559, 1522, 1473, 1382, 1338, 1295, 1259, 1131, 1080, 1059, 999, 918, 862, 837, 815, 791, 754cm⁻¹ I-455 m.p. 168–170° C. ¹HNMR(CD₃OD) δ 1.68(s, 3H), 1.74(s, 3H), 2.50–2.58(m, 2H), 3.41(s, 3H), 3.73(s, 3H), 4.05(t, J=6.9Hz, 2H), 5.29(m, 1H), 6.76–6.79 (m, 2H), 6.98–7.17(m, 6H) IR(KBr)3411, 2964, 2936, 1685, 1613, 1590, 1523, 1472, 1379, 1293, 1259, 1229, 1131, 1082, 1061, 1000, 962, 861, 838, 814, 791, 754, 529cm⁻¹ I-456 m.p. 153–155° C. ¹HNMR(CDCl₃) δ 3.14(s, 3H), 3.50(s, 3H), 3.77(s, 3H), 5.20(s, 2H), 7.10–7.28(m, 6H), 7.38–7.50(m, 5H), 7.56(dd, J=8.4, 2.1Hz, 1H), 7.65(d, J=2.1Hz, 1H), 9.98(s, 1H) IR(CHCl₃)2938, 2843, 1697, 1604, 1590, 1517, 1469, 1372, 1331, 1293, 1254, 1172, 1159, 1123, 1093, 1005, 963, 818cm⁻¹ I-457 m.p. 143–145° C. ¹HNMR(CDCl₃) δ 1.77(s, 3H), 1.83(s, 3H), 3.44(s, 3H), 3.63(s, 3H), 3.75(s, 3H), 4.63(d, J=6.6Hz, 2H), 5.53(m, 1H), 5.72(br, 1H), 6.82– 6.85(m, 2H), 6.92–6.95(m, 2H), 7.16(dd, J=8.4, 2.4Hz, 1H), 7.23–7.26(m, 3H) IR(CHCl₃)3595, 3537, 2938, 1729, 1612, 1591, 1522, 1473, 1395, 1344, 1290, 1258, 1173, 1129, 1081, 1063, 1003, 900, 862, 836cm⁻¹

TABLE 93 I-458 powder ¹HNMR(CDCl₃) δ 2.37(s, 3H), 3.08(s, 3H), 3.11(s, 3H), 3.21(s, 3H), 3.51(s, 3H), 3.52(s, 3H), 5.26(s, 2H), 7.19–7.23(m, 2H), 7.36–7.43 (m, 4H), 7.45–7.50(m, 2H), 7.82(d, J=2.1Hz, 1H), 7.98(d, J=2.1Hz, 1H) IR(CHCl₃)3033, 2942, 1543, 1377, 1220, 1181, 1153, 1034cm⁻¹ I-459 m.p. 182–187° C.(dec.) ¹HNMR(CDCl₃) δ 2.36(s, 3H), 2.73(s, 3H), 3.16(s, 3H), 3.22(s, 3H), 3.43(s, 3H), 3.47(s, 3H), 5.08(s, 2H), 6.85(brs, 1H), 6.92(brs, 1H), 7.17– 7.21(m, 2H), 7.32–7.38(m, 2H), 7.39–7.44(m, 2H), 7.50–7.55(m, 2H) IR(CHCl₃)3030, 2939, 1618, 1599, 1513, 1468, 1416, 1372, 1178, 1150, 1031cm⁻¹ I-460 powder ¹HNMR(CDCl₃) δ 2.38(s, 3H), 2.83(s, 3H), 3.05(s, 3H), 3.22(s, 3H), 3.56(s, 3H), 3.80(s, 3H), 3.91(s, 3H)5.13(s, 2H), 6.86(s, 1H), 7.20–7.24 (m, 2H), 7.37–7.46(m, 4H), 7.65–7.70(m, 3H), 7.89(d, J=2.1Hz, 1H) IR(CHCl₃)3032, 2940, 1728, 1473, 1373, 1232, 1179, 1150, 1085cm⁻¹ I-461 amorphous ¹HNMR(CDCl₃) δ 3.78(s, 6H), 5.16(s, 2H), 5.31(d, J=3.6Hz, 1H), 5.72(s, 1H), 6.91(s, 1H), 6.94(s, 1H), 6.99(d, J=8.2Hz, 1H), 7.04(t, J=8.6Hz, 1H), 7.08(dd, J=8.2, 2.1Hz, 1H), 7.22(d, J=2.1Hz, 1H), 7.25(ddd, J=8.6, 1.8, 0.9Hz, 1H), 7.34–7.46(m, 6H) IR(CHCl₃)3577, 3548, 1526, 1495, 1280, 1635cm⁻¹ I-462 m.p. 153–155° C. ¹HNMR(CDCl₃) δ 3.12(s, 3H), 3.26(s, 3H), 3.80(s, 3H), 3.81(s, 3H), 5.18(s, 2H), 6.91(s, 1H), 6.94(s, 1H), 7.12(d, J=8.4Hz, 1H), 7.36–7.50 (m, 8H), 7.59(d, J=1.8Hz, 1H) IR(CHCl₃)1494, 1367, 1212, 1180, 1116, 872, 808cm⁻¹

TABLE 94 I-463 m.p. 125–127° C. ¹HNMR(CDCl₃) δ 1.77(s, 3H), 1.82(s, 3H), 3.23(s, 3H), 3.27(s, 3H), 3.80(s, 3H), 3.82(s, 3H), 4.64(d, J=6.7Hz, 2H), 5.51(t, J=6.7Hz, 1H), 6.91(s, 1H), 6.95(s, 1H), 7.06(d, J=8.7Hz, 1H), 7.37(dd, J=8.7, 1.9Hz, 1H), 7.40–7.47(m, 2H), 7.50(d, J=2.4Hz, 1H), 7.57(d, J=1.9Hz, 1H), IR(KBr)1523, 1496, 1370, 1213, 1175, 1116, 1035, 977, 832, 807cm⁻¹ I-464 m.p.149–151° C. ¹HNMR(CDCl₃) δ 1.69(s, 3H), 1.74(s, 3H), 2.55(q, J=7.0Hz, 2H), 3.21(s, 3H), 3.26(s, 3H), 3.80(s, 3H), 3.81(s, 3H), 4.07(t, J=7.0Hz, 2H), 5.21(t, J=7.0Hz, 1H), 6.91(s, 1H), 6.94(s, 1H), 7.05(d, J=8.4Hz, 1H), 7.37(dd, J=8.4, 2.1Hz, 1H), 7.40–7.47(m, 2H), 7.50(d, J=2.1Hz, 1H), 7.57(d, J=2.1Hz, 1H) IR(KBr)1523, 1495, 1368, 1212, 1176, 1116, 1035, 976, 832, 806cm⁻¹ I-465 m.p. 148–150° C ¹HNMR(CDCl₃) δ 2.38(s, 3H), 3.11(s, 3H), 3.26(s, 3H), 3.80(s, 3H), 3.81(s, 3H), 5.13(s, 2H), 6.91(s, 1H), 6.94(s, 1H), 7.12(d, J=8.4Hz, 1H), 7.22(d, J=7.8Hz, 2H), 7.35(d, J=7.8Hz, 2H), 7.37(dd, J=8.4, 1.8Hz, 1H), 7.40–7.50(m, 3H), 7.59(d, J=1.8Hz, 1H) IR(KBr)1523, 1490, 1370, 1181, 1115, 971, 868, 806cm⁻¹ I-466 m.p. 109–112° C. ¹HNMR(CDCl₃) δ 1.76(s, 3H), 1.82(s, 3H), 3.79(s, 6H), 4.62(d, J=6.9Hz, 2H), 5.26(d, J=3.9Hz, 1H), 5.52(t, J=6.9Hz, 1H), 5.72(s, 1H), 6.91(s, 1H), 6.93(d, J=8.6Hz, 1H), 6.94(s, 1H), 7.04(t, J=8.7Hz, 1H), 7.07(dd, J=8.6, 2.1Hz, 1H), 7.19(d, J=2.1Hz, 1H), 7.25(ddd, J=8.7, 1.8, 0.9Hz, 1H), 7.37(dd, J=12.0, 1.8Hz, 1H) IR(CHCl₃)3578, 3542, 1526, 1495, 1280, 1055, 1035cm⁻¹

TABLE 95 I-467 amorphous ¹HNMR(CDCl₃) δ 2.39(s, 3H), 3.79(s, 6H), 5.11(s, 2H), 5.40(brs, 1H), 5.73(s, 1H), 6.91(s, 1H), 6.94(s, 1H), 6.99(d, J=8.4Hz, 1H), 7.04 (t, J=8.7Hz, 1H), 7.08(dd, J=8.4, 2.1Hz, 1H), 7.21(d, J=2.1Hz, 1H), 7.23(d, J=7.7Hz, 2H), 7.25(ddd, J=8.7, 2.1, 1.2Hz, 1H), 7.34(d, J=7.7Hz, 2H), 7.37(dd, J=11.7, 2.1Hz, 1H) IR(CHCl₃)3577, 3545, 1526, 1495, 1280, 1055, 1035, 868cm⁻¹ I-468 amorphous ¹HNMR(CDCl₃) δ 1.69(s, 3H), 1.75(s, 3H), 2.53(q, J=7.0Hz, 2H), 3.78(s, 3H), 3.79(s, 3H), 4.07(t, J=7.2Hz, 2H), 5.22(t, J=7.0Hz, 1H), 5.27(d, J=3.9Hz, 1H), 5.71(s, 1H), 6.91(s, 1H), 6.91(d, J=8.6Hz, 1H), 6.94(s, 1H), 7.04(t, J=8.4Hz, 1H), 7.06(dd, J=8.6, 2.1Hz, 1H), 7.19 (d, J=2.1Hz, 1H), 7.25(ddd, J=8.4, 1.9, 1.1Hz, 1H), 7.37(dd, J=12.0, 1.9Hz, 1H) IR(CHCl₃)3578, 1526, 1495, 1280, 1055, 1035cm⁻¹ I-469 m.p. 190–191° C. ¹HNMR(CDCl₃) δ 2.38(s, 3H), 3.11(s, 3H), 3.19(s, 3H), 3.80(s, 6H), 5.13(s, 2H), 6.92(s, 1H), 6.94(s, 1H), 7.12(d, J=8.7Hz, 1H), 7.22(d, J=7.8Hz, 1H), 7.32–7.37(m, 4H), 7.49(dd, J=2.1, 8.4Hz, 1H), 7.59(d, J=1.8Hz, 1H), 7.60–7.65(m, 2H) IR(KBr)3600–2800(br), 1521, 1492, 1468, 1386, 1366, 1336, 1292, 1272, 1259, 1202, 1174, 1150, 1113cm⁻¹ I-470 m.p. 147–148° C. ¹HNMR(CDCl₃) δ 2.37(s, 3H), 3.19(s, 3H), 3.79(s, 3H), 3.80(s, 3H), 5.16(s, 2H), 6.92(s, 1H), 6.93(s, 1H), 7.06(t, J=8.7Hz, 1H), 7.20–7.27 (m, 3H), 7.32–7.41(m, 5H), 7.60–7.64(m, 2H) IR(KBr)3600–2800(br), 1523, 1492, 1462, 1454, 1379, 1359, 1299, 1278, 1264, 1210, 1175, 1151, 1129, 1054, 1031, 1009cm⁻¹ I-471 m.p. 170–172° C. ¹HNMR(CDCl₃) δ 3.19(s, 3H), 3.24(s, 3H), 3.79(s, 3H), 3.80(s, 3H), 5.12(s, 2H), 6.92(s, 1H), 6.94(s, 1H), 7.11(d, J=8.7Hz, 1H), 7.26–7.30 (m, 2H), 7.32–7.37(m, 2H), 7.47(dd, J=2.4, 8.4Hz, 1H), 7.61–7.64(m, 3H), 7.74–7.80(m, 1H), 8.61–8.63(m, 1H) IR(KBr)3600–2800(br), 1522, 1491, 1462, 1361, 1296, 1264, 1212, 1177, 1149, 1115, 1030cm⁻¹

TABLE 96 I-472 m.p. 174–175° C. ¹HNMR(CDCl₃) δ 3.19(s, 3H), 3.79(s, 3H), 3.80(s, 3H), 5.33(s, 2H), 6.92(s, 1H), 6.93(s, 1H), 7.07(d, J=8.7Hz, 1H), 7.23–7.28(m, 2H), 7.32– 7.37(m, 2H), 7.41(dd, J=1.8, 12.6Hz, 1H), 7.60–7.64(m, 3H), 7.73–7.79(m, 1H), 8.60–8.63(m, 1H) IR(KBr)3600–2800(br), 1524, 1491, 1464, 1380, 1361, 1302, 1267, 1209, 1172, 1149, 1130, 1034, 1024, 1008cm⁻¹ I-473 m.p. 118.5–119.5° C. ¹HNMR(CDCl₃) δ 1.77(s, 3H), 1.80(d, J=0.9Hz, 3H), 3.78(s, 3H), 3.79(s, 3H), 4.63(d, J=6.9Hz, 2H), 5.52–5.57(m, 1H), 6.73–6.78(m, 2H), 6.91(s, 1H), 6.93(s, 1H), 7.02(t, J=8.7Hz, 1H), 7.25–7.30(m, 1H), 7.35–7.43(m, 3H) IR(KBr)3600–2800(br), 1625, 1527, 1491, 1461, 1449, 1378, 1298, 1279, 1259, 1207, 1184, 1125, 1055, 1031cm⁻¹ I-474 m.p. 156–158° C. ¹HNMR(CDCl₃) δ 1.77(s, 3H), 1.81(s, 3H), 3.08(s, 3H), 3.80(s, 3H), 3.81(s, 3H), 4.64(d, J=6.6Hz, 2H), 5.52–5.58(m, 1H), 6.43(brs, 1H), 6.93(s, 1H), 6.94(s, 1H), 7.03(t, J=8.4Hz, 1H), 7.26–7.30(m, 3H), 7.37(dd, J=1.8, 12.6Hz, 1H), 7.57–7.61(m, 2H) IR(KBr)3600–2800(br), 1526, 1495, 1463, 1382, 1325, 1300, 1267, 1210, 1156, 1139, 1129, 1054, 1032cm⁻¹ I-475 m.p. 158–160° C. ¹HNMR(CDCl₃) δ 1.77(s, 3H), 1.81(s, 3H), 3.80(s, 6H), 4.64(d, J=6.6Hz, 2H), 4.73(brs, 2H), 5.53–5.57(m, 1H), 6.51(brs, 1H), 6.93(s, 1H), 6.94(s, 1H), 7.03(t, J=8.7Hz, 1H), 7.26–7.31(m, 3H), 7.37(dd, J=2.1, 12.6Hz, 1H), 7.57–7.61(m, 2H) IR(KBr)3600–2800(br), 1527, 1495, 1462, 1395, 1326, 1299, 1264, 1208, 1170, 1130, 1054, 1031cm⁻¹ I-476 m.p. 138–140° C. ¹HNMR(CDCl₃) δ 1.77(s, 3H), 1.81(s, 3H), 2.21(s, 3H), 3.78(s, 3H), 3.80(s, 3H), 4.63(d, J=6.9Hz, 2H), 5.53–5.57(m, 1H), 6.93(s, 1H), 6.94 (s, 1H), 7.03(t, J=8.4Hz, 1H), 7.20(brs, 1H), 7.26–7.30(m, 1H), 7.37(dd, J=2.1, 12.6Hz, 1H), 7.56(m, 4H) IR(KBr)3600–2800(br), 1666, 1604, 1527, 1494, 1463, 1448, 1379, 1317, 1299, 1264, 1209, 1130, 1055, 1032cm⁻¹

TABLE 97 I-477 m.p. 200–202° C. ¹HNMR(CDCl₃ + CD₃OD) δ 1.77(s, 3H), 1.81(s, 3H), 3.79(s, 3H), 3.80(s, 3H), 4.64(d, J=6.6Hz, 2H), 5.52–5.57(m, 1H), 6.93(s, 1H), 6.94 (s, 1H), 7.03(t, J=9.0Hz, 1H), 7.27–7.30(m, 1H), 7.34–7.41(m, 3H), 7.52–7.55(m, 2H) IR(KBr)3600–2800(br), 2404, 1684, 1660, 1584, 1528, 1493, 1462, 1386, 1301, 1274, 1263, 1209, 1132, 1053, 1029cm⁻¹ I-478 m.p. 195–196.5° C. ¹HNMR(CDCl₃) δ 1.55(s, 9H), 3.78(s, 3H), 3.79(s, 3H), 4.85(s, 1H), 6.75(brs, 1H), 6.88–6.92(m, 2H), 6.92(s, 1H), 6.93(s, 1H), 7.31–7.39 (m, 3H), 7.45–7.49(m, 2H), 8.12(t, J=7.5Hz, 1H) IR(KBr)3600–2800(br), 1729, 1590, 1531, 1500, 1464, 1394, 1261, 1240, 1199, 1156, 1055, 1033, 1023cm⁻¹ I-479 m.p. 172–174° C. ¹HNMR(CDCl₃) δ 1.55(s, 9H), 3.19(s, 3H), 3.79(s, 3H), 3.80(s, 3H), 6.75(d, J=2.1Hz, 1H), 6.92(s, 1H), 6.94(s, 1H), 7.26–7.39(m, 5H), 7.60– 7.65(m, 2H) IR(KBr)3600–2800(br), 1728, 1590, 1531, 1513, 1494, 1464, 1391, 1367, 1352, 1240, 1206, 1179, 1145, 1056, 1033, 1024cm⁻¹ I-480 m.p. 152–153° C. ¹HNMR(CDCl₃) δ 1.74(s, 3H), 1.77(s, 3H), 3.18(s, 3H), 3.78(d, J=9.9Hz, 2H), 3.79(s, 6H), 3.93(brs, 1H), 5.35–5.40(m, 1H), 6.75(t, J=8.4Hz, 1H), 6.91(s, 1H), 6.95(s, 1H), 7.24–7.36(m, 4H), 7.60–7.65(m, 2H) IR(KBr)3600–2800(br), 1630, 1530, 1488, 1466, 1380, 1366, 1346, 1259, 1213, 1176, 1149, 1124, 1054, 1027cm⁻¹ I-481 foam ¹HNMR(CDCl₃) δ 2.40(s, 3H), 3.19(s, 3H), 3.77(s, 3H), 3.78(s, 3H), 6.80(t, d=2.4Hz, 1H), 6.90(s, 1H), 6.91(s, 1H), 7.25–7.36(m, 6H), 7.58– 7.65(m, 3H), 7.72–7.76(m, 2H) IR(KBr)3600–2800(br), 1522, 1490, 1366, 1342, 1211, 1164, 1151, 1091, 1053, 1030cm⁻¹

TABLE 98 I-482 m.p. 201–203° C. ¹HNMR(CDCl₃) δ 2.45(s, 3H), 3.20(s, 3H), 3.82(s, 6H), 6.95(s, 1H), 6.98(s, 1H), 7.32–7.48(m, 6H), 7.61–7.66(m, 2H), 7.80–7.84(m, 2H), 8.10(d, J=3.3Hz, 1H), 8.55(d, J=8.4Hz, 1H) IR(KBr)3600–2800(br), 1671, 1592, 1524, 1494, 1388, 1366, 1328, 1265, 1207, 1172, 1150, 1052, 1024cm⁻¹ I-483 m.p. 132–134° C. ¹HNMR(CDCl₃) δ 1.55(s, 9H), 3.00(s, 6H), 3.79(s, 6H), 6.73(d, J=2.4Hz, 1H), 6.81(m, 2H), 6.92(s, 1H), 6.96(s, 1H), 7.32–7.39(m, 2H), 7.48–7.52(m, 2H), 8.11(t, J=8.1Hz, 1H) IR(KBr)3600–2800(br), 1728, 1610, 1591, 1533, 1499, 1459, 1446, 1381, 1365, 1238, 1206, 1159, 1055, 1030cm⁻¹ I-484 foam ¹HNMR(CDCl₃) δ 1.74(s, 3H), 1.77(s, 3H), 3.00(s, 6H), 3.78(d, J=9.6Hz, 1H), 3.78(s, 3H), 3.79(s, 3H), 5.34–5.38(m, 1H), 6.75(t, J=8.4Hz, 1H), 6.92(s, 1H), 6.94(s, 1H), 6.93–6.95(m, 1H), 7.23–7.32(m, 3H), 7.48–7.52(m, 2H) IR(KBr)3600–2800(br), 1625, 1611, 1531, 1494, 1446, 1380, 1340, 1257, 1207, 1123, 1055, 1032cm⁻¹ I-485 foam ¹HNMR(CDCl₃) δ 2.40(s, 3H), 3.00(s, 6H), 3.76(s, 3H), 3.77(s, 3H), 6.70(t, J=2.4Hz, 1H), 6.80(t, J=8.7Hz, 2H), 6.87(s, 1H), 6.94(s, 1H), 7.24–7.33(m, 4H), 7.46–7.50(m, 2H), 7.60(t, J=9.0Hz, 1H), 7.71–7.75(m, 2H) IR(KBr)3600–2800(br), 1609, 1529, 1493, 1446, 1381, 1340, 1208, 1164, 1090, 1054, 1031cm⁻¹ I-486 m.p. 184–186° C. ¹HNMR(CDCl₃) δ 2.45(s, 3H), 3.01(s, 6H), 3.80(s, 3H), 3.81(s, 3H), 6.82(d, J=7.5Hz, 2H), 6.95(s, 1H), 6.98(s, 1H), 7.32(d, J=8.1Hz, 2H), 7.40–7.52(m, 4H), 7.80–7.84(m, 2H), 8.08(d, J=2.7Hz, 1H), 8.52(t, J=8.4Hz, 1H) IR(KBr)3600–2800(br), 1647, 1608, 1530, 1497, 1379, 1365, 1284, 1267, 1206, 1051, 1030cm⁻¹

TABLE 99 I-487 foam ¹HNMR(CDCl₃) δ 2.36(s, 3H), 3.77(s, 6H), 4.81(brs, 1H), 6.69(dd, J=0.9, 3.6Hz, 1H), 6.88–6.92(m, 2H), 6.94(s, 1H), 6.95(s, 1H), 7.23–7.26 (m, 2H), 7.46–7.51(m, 2H), 7.53(dd, J=1.5, 8.4Hz, 1H), 7.59(d, J=3.6Hz, 1H), 7.73(d, J=0.9Hz, 1H), 7.80–7.84(m, 2H), 8.02(d, J=8.4Hz, 1H) IR(KBr)3600–2800(br), 1611, 1594, 1520, 1498, 1459, 1444, 1369, 1259, 1208, 1170, 1129, 1092, 1051, 1028cm⁻¹ I-488 m.p. 219–220° C. ¹HNMR(CDCl₃) δ 2.37(s, 3H), 3.19(s, 3H), 3.78(s, 3H), 3.79(s, 3H), 6.70(dd, J=0.9, 3.6Hz, 1H), 6.94(s, 1H), 6.97(s, 1H), 7.24–7.27(m, 2H), 7.32–7.37(m, 2H), 7.53(dd, J=1.8, 8.7Hz, 1H), 7.60(d, J=3.6Hz, 1H), 7.61–7.66(m, 2H), 7.73(d, J=0.9Hz, 1H), 7.80–7.84(m, 2H), 8.03 (d, J=8.7Hz, 1H) IR(KBr)3600–2800(br), 1513, 1494, 1464, 1444, 1373, 1209, 1173, 1155, 1122, 1049cm⁻¹ I-489 ¹HNMR(CDCl₃) δ 3.79(s, 3H), 3.80(s, 3H), 3.94(s, 3H), 5.17(s, 2H), 5.71(s, 1H), 6.96(s, 1H), 6.97(s, 1H), 6.99(d, J=8.7Hz, 1H), 7.09(d.d, J=8.7&2.4Hz, 1H), 7.22(d, J=2.4Hz), 7.26(s, 1H), 7.32–7.49(m, 5H), 7.66(d, J=8.7Hz, 2H), 8.09(d, J=8.7Hz, 2H) IR(KBr)3383, 1702, 1606, 1489, 1381, 1291, 1206, 1111, 1032, 1002cm⁻¹ I-490 ¹HNMR(CDCl₃) δ 3.12(s, 3H), 3.79(s, 3H), 3.81(s, 3H), 3.95(s, 3H), 5.18(s, 2H), 6.96(s, 2H), 7.12(d, J=8.4Hz, 1H), 7.31–7.53(m, 6H), 7.60 (d, J=2.1Hz, 1H), 7.65(d, J=8.7Hz, 2H), 8.10(d, J=8.7Hz, 2H) IR(KBr)1720, 1607, 1492, 1362, 1275, 1211, 1112, 1057, 1032cm⁻¹ I-491 ¹HNMR(CDCl₃) δ 3.12(s, 3H), 3.80(s, 3H), 3.81(s, 3H), 5.18(s, 2H), 6.92(s, 1H), 6.96(s, 1H), 7.13(d, J=8.4Hz, 1H), 7.31–7.52(m, 6H), 7.70 (d, J=2.1Hz, 1H), 7.66–7.77(m, 4H) IR(KBr)3433, 1685, 1606, 1509, 1492, 1372, 1318, 1264, 1211, 1183, 1111, 1055, 1031cm⁻¹ I-492 ¹HNMR(CDCl₃) δ 3.79(s, 3H), 3.80(s, 3H), 5.17(s, 2H), 5.71(s, 2H), 6.91(s, 1H), 6.97(s, 1H), 7.00(d, J=8.4Hz, 1H), 7.08(dd, J=8.4&2.4Hz, 1H), 7.22(d, J=2.4Hz, 1H), 7.32–7.49(m, 5H), 7.70(s, 4H) IR(KBr)3291, 2242, 1607, 1579, 1488, 1384, 1324, 1272, 1209, 1130, 1054, 1034, 1001cm⁻¹

TABLE 100 I-493 ¹HNMR(CDCl₃) δ 3.12(s, 3H), 3.80(s, 3H), 3.81(s, 3H), 5.18(s, 2H), 6.92(s, 1H), 6.96(s, 1H), 7.12(d, J=8.4Hz, 1H), 7.31–7.72(m, 6H), 7.60 (d, J=1.8Hz, 1H), 7.65–7.74(m, 4H) IR(KBr)2223, 1604, 1490, 1363, 1296, 1264, 1213, 1172, 1117, 1055, 1036, 1026cm⁻¹ I-494 ¹HNMR(CDCl₃) δ 1.77(s, 3H), 1.81(s, 3H), 3.23(s, 3H), 3.80(s, 3H), 3.81(s, 3H), 3.95(s, 3H), 4.64(d, J=6.6Hz, 2H), 5.51(t, J=6.6Hz, 1H), 6.96(s, 2H), 7.06(d, J=8.7Hz, 1H), 7.50(d.d, J=8.7&2.1Hz, 1H), 7.59(d, J=2.1Hz, 1H), 7.65(d, J=8.7Hz, 2H), 8.10(d, J=8.7Hz, 2H) IR(KBr)1720, 1608, 1508, 1492, 1384, 1357, 1273, 1179, 1110, 1026, 1019cm⁻¹ I-495 ¹HNMR(CDCl₃) δ 2.38(s, 3H), 3.12(s, 3H), 3.80(s, 6H), 3.81(s, 3H), 3.95(s, 3H), 5.14(s, 2H), 6.96(s, 2H), 7.13(d, J=8.4Hz, 1H), 7.21(d, J=7.8Hz, 2H), 7.35(d, J=7.8Hz, 2H), 7.49(d.d, J=8.4&1.8Hz, 1H), 7.60(d, J=1.8Hz, 1H), 7.65(d, J=8.7Hz, 2H), 8.10(d, J=8.7Hz, 2H) IR(KBr)1697, 1607, 1492, 1364, 1286, 1263, 1213, 1178, 11115, 1057, 1030cm⁻¹ I-496 IR(KBr)1730, 1701, 1610, 1515, 1465, 1359, 1238, 1186, 1116, 1082, 1064, 1016cm⁻¹ I-497 ¹HNMR(CDCl₃) δ 1.75(s, 3H), 1.80(s, 3H), 2.89(s, 6H), 3.21(s, 3H), 3.44(s, 3H), 3.68(s, 3H), 3.77(s, 1H), 4.61(d, J=8.4Hz, 2H), 5.49(t, J= 8.4Hz, 1H), 6.92(s, 1H), 7.01(d, J=8.4Hz, 1H), 7.25–7.28(m, 3H), 7.33(d, J=2.1Hz, 1H), 7.52(dd, J=8.4&1.8Hz, 1H), 7.66(d, J=2.4Hz, 1H) IR(KBr)1727, 1598, 1515, 1467, 1360, 1295, 1258, 1241, 1116, 1084cm⁻¹ I-498 ¹HNMR(CDCl₃) δ 2.38(s, 3H), 2.89(s, 6H), 3.10(s, 3H), 3.44(s, 3H), 3.66(s, 3H), 3.77(s, 3H), 5.11(s, 3H), 6.93(s, 1H), 7.06–7.15(m, 2H), 7.17–7.29(m, 4H), 7.31–7.37(m, 3H), 7.53(d.d, J=8.7&1.8Hz, 1H), 7.66(dJ=1.8Hz, 1H) IR(KBr)1732, 1701, 1598, 1518, 1466, 1352, 1294, 1121, 1085, 1060, 1015cm⁻¹ I-499 ¹HNMR(CDCl₃) δ 2.88(s, 6H), 3.44(s, 3H), 3.64(s, 3H), 3.77(s, 3H), 5.17(s, 2H), 5.65(s, 1H), 6.84(dd, J=8.1&2.1Hz, 1H), 6.92(s, 1H), 6.95 (d, J=8.1Hz, 1H), 7.01(d, J=2.1Hz, 1H), 7.12(d, J=8.4Hz, 1H), 7.31–7.46(m, 6H), 7.53(d.d, J=8.4&1.8Hz, 1H), 7.66(d, J=1.8Hz, 1H) IR(KBr)3526, 3434, 1732, 1598, 1515, 1460, 1344, 1260, 1240, 1222, 1061, 1013cm⁻ ¹

TABLE 101 I-500 ¹HNMR(CDCl₃) δ 2.60(s, 3H), 3.43(s, 3H), 3.72(s, 3H), 3.75(s, 3H), 5.17(s, 2H), 5.67(s, 1H), 6.77(s, 1H), 6.94(dd, J=8.4&1.8Hz, 1H), 7.02 (d, J=8.4Hz, 1H), 7.06(d, J=1.8Hz, 1H), 7.32–7.50(m, 7H), 7.53–7.62(m, 1H), 7.94(d, J=7.8Hz, 1H) IR(KBr)1732, 1719, 1585, 1521, 1481, 1403, 1352, 1289, 1253, 1225, 1172, 1073, 1012cm⁻¹ I-501 ¹HNMR(CDCl₃) δ 2.73(s, 3H), 3.12(s, 3H), 3.43(s, 3H), 3.72(s, 3H), 3.76(s, 3H), 5.19(s, 2H), 6.78(s, 1H), 7.15(d, J=8.4Hz, 1H), 7.31–7.63 (m, 10H), 9.96(d, J=6.6Hz, 1H) IR(KBr)1726, 1609, 1520, 1480, 1400, 1371, 1294, 1262, 1179, 1075, 1009cm⁻¹ I-502 ¹HNMR(CDCl₃) δ 1.78(s, 3H), 1.81(s, 3H), 3.22(s, 3H), 3.48(s, 3H), 3.71(s, 3H), 3.77(s, 3H), 3.82(s, 3H), 4.66(d, J=6.9Hz, 2H), 5.56(t, J=6.9Hz, 1H), 6.62(s, 1H), 6.70(s, 1H), 7.11(s, 1H), 7.38(d, J=8.7Hz, 1H), 7.69(d, J=8.7Hz, 1H) IR(KBr)1699, 1607, 1587, 1516, 1468, 1354, 1216, 1152, 1067, 1044, 1004cm⁻¹ I-503 ¹HNMR(CDCl₃) δ 1.78(s, 3H), 1.81(s, 3H), 3.21(s, 3H), 3.48(s, 3H), 3.72(s, 3H), 3.74(s, 3H), 3.82(s, 3H), 4.33(d, J=11.7Hz, 1H), 4.54(d, J=11.7Hz, 1H), 4.65(d, J=8.4Hz, 1H), 5.57(t, J=8.4Hz, 1H), 6.68(s, 1H), 6.69(s, 1H), 6.89(s, 1H), 7.38(d, J=8.7Hz, 2H), 7.73(d, J=8.7Hz, 2H) IR(KBr)3530, 1609, 1515, 1467, 1356, 1214, 1174, 1151, 1075, 1039, 1004cm⁻¹ I-504 ¹HNMR(CDCl₃) δ 1.77(s, 3H), 1.80(s, 3H), 3.22(s, 3H), 3.45(s, 3H), 3.75(s, 3H), 3.77(s, 3H), 3.81(s, 3H), 4.62(d, J=6.9Hz, 2H), 5.55(t, J= 6.9Hz, 1H), 6.64(s, 1H), 6.77(s, 1H), 6.97(s, 1H), 7.39(d, J=8.7Hz, 2H), 7.72(d, J=8.7Hz, 2H) IR(KBr)3431, 1735, 1706, 1609, 1514, 1474, 1367, 1206, 1176, 1150, 1055, 1039cm⁻¹ I-505 ¹HNMR(CDCl₃) δ 1.77(s, 3H), 1.80(s, 3H), 2.94(broad, 1H), 3.47(s, 3H), 3.72(s, 3H), 3.73(s, 3H), 3.81(s, 3H), 4.32(s, 1H), 4.36(s, 1H), 4.65 (d, J=6.6Hz, 2H), 5.34(s, 1H), 5.57(t, J=6.6Hz, 1H), 6.69(s, 1H), 6.70(s, 1H), 6.89(s, 1H), 6.91(d, J=8.1Hz, 2H), 7.55(d, J=8.1Hz, 2H) IR(KBr)3466, 1610, 1517, 1475, 1463, 1386, 1265, 1215, 1170, 1147, 1075, 1042, 1007cm⁻¹ I-506 ¹HNMR(CDCl₃) δ 1.76(s, 3H), 1.79(s, 3H), 3.44(s, 3H), 3.74(s, 3H), 3.76(s, 3H), 3.80(s, 3H), 4.63(d, J=7.2Hz, 2H), 5.30(s, 1H), 5.49–5.60 (m, 1H), 6.63(s, 1H), 6.78(s, 1H), 6.94(d, J=8.7Hz, 2H), 6.97(s, 1H), 7.54(d, J=8.7Hz, 2H) IR(KBr)3382, 1726, 1699, 1611, 1519, 1470, 1206, 1174, 1143, 1074, 1056, 997cm⁻¹

TABLE 102 I-507 ¹HNMR(CDCl₃) δ 1.77(s, 3H), 1.79(s, 3H), 3.41(s, 3H), 3.60(s, 3H), 3.74(s, 3H), 3.77(s, 3H), 3.81(s, 3H), 4.63(d, J=6.9Hz, 2H), 4.74–5.02(broad, 1H), 5.52–5.60(m, 1H), 6.63(s, 1H), 6.75(s, 1H), 6.91(d, J=8.7Hz, 2H), 6.94(s, 1H), 7.54(d, J=8.7Hz, 2H) IR(KBr)3423, 1734, 1612, 1520, 1475, 1441, 1395, 1337, 1267, 1215, 1173, 1140, 1017cm⁻¹ I-508 ¹HNMR(CDCl₃) δ 3.21(s, 3H), 3.45(s, 3H), 3.73(s, 3H), 4.41–4.62(m, 2H), 5.16(s, 2H), 5.71(s, 1H), 6.79(d.d, J=8.1&2.1Hz, 1H), 6.84(s, 1H), 6.92(d, J=2.1Hz, 1H), 7.01(d, J=8.1Hz, 1H), 7.32–7.50(m, 7H), 7.71(d, J=8.4Hz, 2H) IR(KBr)3496, 3255, 1607, 1590, 1528, 1473, 1464, 1358, 1247, 1147, 1071, 1017cm⁻¹ I-509 ¹HNMR(CDCl₃) δ 3.21(s, 3H), 3.45(s, 3H), 3.73(s, 3H), 3.89(s, 3H), 4.51(d, J=6.3Hz, 2H), 5.20(s, 2H), 6.80(d.d, J=8.1&2.1Hz, 1H), 6.85 (s, 1H), 6.89(d, J=2.1Hz, 1H), 6.97(d, J=8.1Hz, 1H), 7.29–7.51(m, 7H), 7.71(d, J=8.7Hz, 2H) IR(KBr)3412, 1603, 1586, 1515, 1464, 1364, 1242, 1175, 1151, 1081, 1020, 1006cm⁻¹ I-510 ¹HNMR(CDCl₃) δ 1.76(s, 3H), 1.80(s, 3H), 3.22(s, 3H), 3.45(s, 3H), 3.73(s, 3H), 3.87(s, 3H), 4.52(s, 2H), 4.64(d, J=6.6Hz, 2H), 5.57(t, J=6.6Hz, 1H), 6.83(dd, J=7.5&1.2Hz, 1H), 6.86(d, J=1.2Hz, 1H), 6.96(d, J=7.5Hz, 1H) IR(KBr)3433, 1598, 1579, 1517, 1469, 1372, 1244, 1221, 1174, 1149, 1072, 1017cm⁻¹ I-511 ¹HNMR(CDCl₃) δ 2.36(s, 3H), 3.21(s, 3H), 3.45(s, 3H), 3.72(s, 3H), 3.88(s, 3H), 4.50(s, 2H), 5.16(s, 2H), 6.80(dd, J=8.1&2.1Hz, 1H), 6.85 (s, 1H), 6.88(d, J=2.1Hz, 1H), 6.97(d, J=8.1Hz, 1H), 7.20(d, J=8.4Hz, 2H), 7.33–7.42(m, 4H), 7.71(d, J=8.4Hz, 2H) IR(KBr)3502, 1604, 1510, 1465, 1383, 1360, 1266, 1239, 1227, 1147, 1071, 1008cm⁻¹ I-512 ¹HNMR(CDCl₃) δ 3.45(s, 3H), 3.72(s, 3H), 3.89(s, 3H), 4.48(s, 2H), 5.20(s, 2H), 6.81(dd, J=8.1&2.1Hz, 1H), 6.86(s, 1H), 6.88–6.99 (m, 4H), 7.27–7.43(m, 3H), 7.46–7.54(m, 4H) IR(KBr)3528, 1610, 1591, 1517, 1474, 1461, 1438, 1388, 1263, 1239, 1173, 1140, 1017cm⁻¹ I-513 ¹HNMR(CDCl₃) δ 1.75(s, 3H), 1.79(s, 3H), 2.47(broads, 1H), 3.45(s, 3H), 3.73(s, 3H), 3.86(s, 3H), 4.52(s, 2H), 4.63(d, J=6.6Hz, 2H), 5.16 (s, 1H), 5.56(d, J=6.6Hz, 1H), 6.82–6.97(m, 6H), 7.53(d, J=9.0Hz, 2H) IR(KBr)3477, 3246, 1609, 1586, 1518, 1464, 1439, 1387, 1266, 1240, 1221, 1173, 1141, 1079, 1011, 1002cm⁻¹

TABLE 103 I-514 ¹HNMR(CDCl₃) δ 2.36(s, 3H), 2.48(broad, 1H), 3.44(s, 3H), 3.72(s, 3H), 3.88(s, 3H), 4.50(s, 2H), 5.16(s, 3H), 6.76–6.98(m, 6H), 7.19(d, J=7.8Hz, 2H), 7.36(d, J=7.8Hz, 2H), 7.52(d, J=8.7Hz, 2H) IR(KBr)3544, 3239, 1614, 1593, 1519, 1463, 1386, 1266, 1240, 1218, 1173, 1139, 1074, 1010cm⁻¹ I-515 m.p. 159–160° C. ¹HNMR(CDCl₃) δ 3.19(s, 3H), 3.34(s, 3H), 3.79(s, 3H), 3.80(s, 3H), 5.18(ABq, J=12.3Hz, 2H), 6.92(s, 1H), 6.93(s, 1H), 7.08(d, J=8.7Hz, 1H), 7.33–7.64(m, 11H) IR(KBr)3433, 2937, 1694, 1520, 1492, 1369, 1288, 1243, 1211, 1176, 1150, 1100cm⁻¹ I-516 ¹HNMR(CDCl₃) δ 2.91(s, 3H), 3.777(s, 3H), 3.783(s, 3H), 4.85(brs, 1H), 5.12(s, 2H), 6.87–7.00(m, 7H), 7.32–7.50(m, 7H) IR(KBr)3432, 2938, 1609, 1590, 1525, 1494, 1380, 1254, 1207, 1174, 1152, 1058, 1031cm⁻¹ I-517 m.p. 213–215° C. ¹HNMR(CDCl₃) δ 2.99(s, 3H), 3.779(s, 3H), 3.804(s, 3H), 4.86(brs, 1H), 5.16(s, 2H), 6.83(brs, 1H), 6.93(s, 1H), 6.94(s, 1H), 7.06(d, J=8.7Hz, 1H), 7.35(dd, J=2.1, 8.7Hz, 1H), 7.41–7.49(m, 7H), 7.81(d, J=2.1Hz, 1H) IR(KBr)3409, 3374, 1610, 1525, 1491, 1371, 1321, 1251, 1208, 1145, 1120, 1037cm⁻¹ I-518 powder ¹HNMR(CDCl₃) δ 1.75(s, 3H), 1.81(s, 3H), 2.84(s, 3H), 3.21(s, 3H), 3.22(s, 3H), 3.55(s, 3H), 3.79(s, 3H), 3.93(s, 3H), 4.67(d, J=7.2Hz, 2H), 5.59(m, 1H), 6.85(s, 1H), 7.36–7.42(m, 2H), 7.62(d, J=2.1Hz, 1H), 7.65–7.70(m, 2H), 7.86(d, J=2.1Hz, 1H) IR(CHCl₃)3026, 2940, 1728, 1510, 1473, 1373, 1179, 1150, 1086cm⁻¹ I-519 powder ¹HNMR(CDCl₃) δ 1.69(s, 3H), 1.74(s, 3H), 2.52–2.61(m, 2H), 2.86(s, 3H), 3.20(s, 3H), 3.21(s, 3H), 3.55(s, 3H), 3.79(s, 3H), 3.93(s, 3H), 4.21(t, J=6.9Hz, 2H), 5.26(m, 1H), 6.86(s, 1H), 7.36–7.42(m, 2H), 7.62(d, J=2.1Hz, 1H), 7.65–7.70(m, 2H), 7.86(d, J=2.1Hz, 1H) IR(CHCl₃)3024, 2939, 1729, 1511, 1475, 1447, 1373, 1179, 1150, 1085cm⁻¹

TABLE 104 I-520 powder ¹HNMR(CDCl₃) δ 2.84(s, 3H), 3.21(s, 3H), 3.22(s, 3H), 3.56(s, 3H), 3.81(s, 3H), 3.88(s, 3H), 5.30(s, 2H), 6.86(s, 1H), 7.26–7.32(m, 1H), 7.37–7.42(m, 2H), 7.65–7.72(m, 4H), 7.76–7.83(m, 1H), 7.92(d, J=2.1Hz, 1H), 8.60–8.63(m, 1H) IR(KBr)3434, 3019, 2940, 1730, 1511, 1474, 1367, 1178, 1151, 1082cm⁻¹ I-521 powder ¹HNMR(CDCl₃ + CD₃OD) δ 1.69(s, 3H), 1.77(s, 3H), 2.51–2.58(m, 2H), 3.43(s, 3H), 3.73(s, 3H), 4.23(t, J=6.6Hz, 2H), 6.44(s, 1H), 6.89–6.95(m, 2H), 7.24(d, J=1.8Hz, 1H), 7.46–7.52(m, 2H), 7.65–7.67(m, 1H) IR(KBr)3434, 2934, 1716, 1611, 1402, 1226, 1116, 1082, 1027cm⁻¹ I-522 m.p. 240–243° C. ¹HNMR(CDCl₃ + CD₃OD) δ 3.44(s, 3H), 3.75(s, 3H), 5.31(s, 2H), 6.46(s, 1H), 6.89–6.95(m, 2H), 7.30–7.31(m, 1H), 7.35–7.42(m, 2H), 7.47–7.53(m, 2H), 7.56(d, J=2.4Hz, 1H), 7.79–7.86(m, 1H), 8.65–8.68(m, 1H) IR(KBr)3411, 2937, 1683, 1611, 1521, 1406, 1230, 1115, 1082, 1026cm⁻¹ I-523 m.p. 136–137° C. ¹HNMR(CDCl₃) δ 2.25(s, 3H), 2.29(s, 3H), 3.12(s, 3H), 3.20(s, 3H), 5.18(s, 2H), 7.11(s, 1H), 7.14(s, 1H), 7.23–7.51(m, 12H) IR(KBr)1518, 1488, 1357, 1263, 1170, 1150, 1110, 970, 873, 848, 809cm⁻¹ I-524 m.p. 121–122° C. ¹HNMR(CDCl₃) δ 1.77(s, 3H), 1.82(s, 3H), 2.25(s, 3H), 2.29(s, 3H), 3.20(s, 3H), 3.23(s, 3H), 4.64(d, J=6.6Hz, 2H), 5.52(t, J=6.6Hz, 1H), 7.06(d, J=8.4Hz, 1H), 7.11(s, 1H), 7.14(s, 1H), 7.24(d, J=2.1Hz, 1H), 7.31–7.45(m, 5H) IR(KBr)1518, 1487, 1363, 1170, 1150, 1108, 970, 869, 848, 808cm⁻¹ I-525 m.p. 149–151° C. ¹HNMR(CDCl₃) δ 1.77(s, 3H), 1.83(d, J=0.6Hz, 3H), 2.26(s, 3H), 2.28(s, 3H), 4.62(d, J=6.9Hz, 2H), 4.80(s, 1H), 5.53(m, 1H), 5.72(s, 1H), 6.82(dd, J=2.1, 8.4Hz, 1H), 6.85–6.94(m, 3H), 6.96(d, J=2.1Hz, 1H), 7.10(s, 1H), 7.12(s, 1H), 7.21–7.28(m, 2H) IR(KBr)3521, 3395, 1612, 1584, 1522, 1490, 1457, 1285, 1263, 1242, 1200, 1170, 1125, 1014, 834cm⁻¹

TABLE 105 I-526 foam ¹HNMR(CDCl₃) δ 2.43(s, 3H), 2.76(s, 3H), 2.90(s, 3H), 3.22(s, 3H), 3.56(s, 3H), 3.80(s, 3H), 5.30(s, 2H), 6.28(t, J=3.3Hz, 1H), 6.42(dd, J=3.3, 1.6Hz, 1H), 6.85(s, 1H), 7.12, (d, J=8.4Hz, 1H), 7.32(d, J=8.7Hz, 2H), 7.34–7.37(m, 2H), 7.39(d, J=8.7Hz, 2H), 7.40(d, J= 1.8Hz, 1H), 7.69(d, J=8.7Hz, 2H), 7.78(d, J=8.7Hz, 2H) IR(Nujol)1608, 1597, 1519, 1480, 1464, 1176, 1152, 1087, 972, 875, 817, 798cm⁻¹ I-527 foam ¹HNMR(CDCl₃) δ 2.96(s, 3H), 3.21(s, 3H), 3.37(s, 3H), 3.52(s, 3H), 3.77(s, 3H), 5.58(s, 2H), 6.84(s, 1H), 7.19(d, J=8.4Hz, 1H), 7.24–7.28 (m, 4H), 7.31, (dd, J=8.4, 1.8Hz, 1H), 7.33(d, J=1.8Hz, 1H), 7.38(d, J=8.7Hz, 2H), 7.67(d, J=8.7Hz, 2H) IR(Nujol)1664, 1609, 1519, 1480, 1457, 1176, 1151, 1079, 970, 947, 876, 798, 748cm⁻¹ I-528 foam ¹HNMR(CDCl₃) δ 2.73(s, 3H), 2.94(s, 3H), 3.21(s, 3H), 3.33(t, J=6.3Hz, 2H), 3.55(s, 3H), 3.77(s, 3H), 4.55(t, J=6.3Hz, 2H), 6.83(s, 1H), 7.14(d, J=8.1Hz, 1H), 7.18(brdd, J=7.8, 5.1Hz, 1H), 7.33(brd, J=7.8Hz, 1H), 7.35(dd, J=8.1, 1.8Hz, 1H), 7.37(d, J=1.8Hz, 1H), 7.38(d, J=8.7Hz, 2H), 7.65(m, 1H), 7.67(d, J=8.7Hz, 2H), 8.56(brd, J=5.1Hz, 1H) IR(Nujol)1608, 1593, 1520, 1479, 1466, 1177, 1151, 1079, 970, 872, 816, 798cm⁻¹ I-529 m.p. 203–205° C. HNMR(DMSO-d₆) δ 2.42(s, 3H), 2.80(s, 3H), 3.45(s, 3H), 3.51(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 5.36(s, 2H), 7.07(s, 1H), 7.23(s, 1H), 7.26–7.28(m, 3H), 7.48, (d, J=8.7Hz, 2H), 7.74(d, J=8.7Hz, 2H) IR(Nujol)1599, 1518, 1480, 1466, 1176, 1081, 1013, 976, 870, 830, 797, 755cm⁻¹ I-530 foam ¹HNMR(CD₃OD) δ 3.38(s, 3H), 3.68(s, 3H), 5.41(s, 2H), 6.44(s, 1H), 6.82(dd, J=8.4, 2.1Hz, 1H), 6.85(d, J=8.7Hz, 2H), 6.93(d, J=2.1Hz, 1H), 7.06(d, J=8.4Hz, 1H), 7.27(m, 2H), 7.46(d, J=8.7Hz, 2H), 7.60(m, 2H) IR(Nujol)3304, 161, 1590, 1522, 1488, 1458, 1254, 1115, 1074, 1046, 1014, 942, 825, 745cm⁻¹

TABLE 106 I-531 m.p. 159–162° C. ¹HNMR(DMSO-d₆) δ 2.92(s, 3H), 3.41(s, 3H), 3.45(s, 3H), 3.52(s, 3H), 3.79(s, 3H), 5.33(s, 2H), 7.09(s, 1H), 6.82–7.45(m, 3H), 7.49(d, J=9.0Hz, 2H), 7.75(d, J=9.0Hz, 2H) IR(Nujol)1604, 1519, 1481, 1469, 1235, 1171, 1154, 1085, 1012, 967, 874, 849, 798cm⁻¹ I-532 m.p. 214–216° C. ¹HNMR(DMSO-d₆) δ 2.84(s, 3H), 3.42(s, 3H), 3.45(s, 3H), 3.52(s, 3H), 3.73(s, 3H), 3.79(s, 3H), 4.99(s, 2H), 7.08(s, 1H), 7.24(dJ=9.3Hz, 1H), 7.29(dd, J=9.3, 1.8Hz, 1H), 7.30(d, J=1.8Hz, 1H), 7.48(d, J=8.7Hz, 2H), 7.74(d, J=8.7Hz, 2H) IR(Nujol)1767, 1606, 1521, 1481, 1463, 1216, 1175, 1151, 1080, 1013, 977, 946, 878, 821, 798cm⁻¹ I-533 m.p. 225–227° C. ¹HNMR(DMSO-d₆) δ 2.86(s, 3H), 3.45(s, 3H), 3.46(s, 3H), 3.52(s, 3H), 3.78(s, 3H), 4.46(s, 2H), 7.08(s, 1H), 7.20(d, J=8.4Hz, 1H), 7.28–7.32 (m, 2H), 7.48(d, J=8.7Hz, 2H), 7.74(d, J=8.7Hz, 2H) IR(Nujol)3340, 1677, 1619, 1519, 1477, 1463, 1443, 1176, 1150, 1088, 971, 871, 829, 794cm⁻¹ I-534 foam ¹HNMR(DMSO-d₆) δ 2.96(s, 3H), 3.45(s, 3H), 3.47(s, 3H), 3.52(s, 3H), 3.79(s, 3H), 4.64(s, 2H), 7.08(s, 1H), 7.18(d, J=8.4Hz, 1H), 7.31 (dd, J=8.4, 1.8Hz, 1H), 7.34(d, J=1.8Hz, 1H), 7.48(d, J=8.7Hz, 2H), 7.74(d, J=8.7Hz, 2H) IR(Nujol)3464, 3362, 1693, 1606, 1520, 1481, 1176, 1151, 1080, 876, 822, 799cm⁻¹ I-535 m.p. 163–165° C. ¹HNMR(CDCl₃) δ 2.73(s, 3H), 3.16(s, 3H), 3.21(s, 3H), 3.55(s, 3H), 3.78(s, 3H), 4.85(ddd, J=1.5, 1.5, 5.4Hz, 2H), 5.25(s, 2H), 5.31, (dd d, J=1.5, 3.0, 10.5Hz, 1H), 5.43(ddd, J=1.5, 3.0, 17.1Hz, 1H), 6.05(ddd, J=5.4, 10.5, 17.1Hz, 1H), 6.84(s, 1H), 7.11(d, J=8.7Hz, 1H), 7.34 (dd, J=2.1, 8.7Hz, 1H), 7.38(d, J=8.4Hz, 2H), 7.41(d, J=2.1Hz, 1H), 7.56(d, J=8.4Hz, 2H), 7.67(d, J=8.4Hz, 2H), 8.11(d, J=8.4Hz, 2H) IR(KBr)1718, 1612, 1519, 1481, 1365, 1273, 1177, 1151, 1119, 1080, 1015, 969, 876cm⁻¹

TABLE 107 I-536 m.p. 115–117° C. ¹HNMR(CDCl₃) δ 2.68(s, 3H), 3.13(s, 3H), 3.21(s, 3H), 3.55(s, 3H), 3.68(s, 2H), 3.78(s, 3H), 4.61(ddd, J=1.5, 1.5, 5.7Hz, 2H), 5.17(s, 2H), 5.23, (ddd, J=1.5, 3.0, 10.5,Hz, 1H), 5.28(ddd, J=1.5, 3.0, 16.8Hz, 1H), 5.91(ddd, J=5.7, 10.5, 16.8Hz, 1H), 6.84(s, 1H), 7.13(d, J=8.4Hz, 1H), 7.33(d, J=8.1Hz, 2H), 7.34(dd, J=2.1, 8.4Hz, 1H), 7.38(d, J=8.4Hz, 2H), 7.40(d, J=2.1Hz, 1H), 7.42(d, J=8.1Hz, 2H), 7.68(d, J=8.4Hz, 2H) IR(KBr)1734, 1609, 1520, 1481, 1365, 1236, 1177, 1151, 1119, 1079, 970, 876, 797cm⁻¹ I-537 m.p. 227–229° C. ¹HNMR(CDCl₃) δ 2.73(s, 3H), 3.16(s, 3H), 3.21(s, 3H), 3.54(s, 3H), 3.77(s, 3H), 5.26(s, 2H), 6.83(s, 1H), 7.11(d, J=12.3Hz, 2H), 7.32(s, 1H), 7.37(d, J=12.3Hz, 2H), 7.41(s, 1H), 7.57(d, J=12.3Hz, 1H), 7.66(d, J=12.3Hz, 2H), 8.13(d, J=12.3Hz, 2H) IR(KBr)3430, 1694, 1612, 1519, 1481, 1365, 1177, 1151, 1079, 875, 798cm⁻¹ I-538 m.p. 149–151° C. ¹HNMR(CDCl₃) δ 2.66(s, 3H), 3.13(s, 3H), 3.21(s, 3H), 3.55(s, 3H), 3.68(s, 2H), 3.77(s, 3H), 5.17(s, 2H), 6.84(s, 1H), 7.13(d, J=8.4Hz, 1H), 7.30–7.55(m, 4H), 7.38(d, J=8.4Hz, 2H), 7.67(d, J=8.4Hz, 2H), 7.67(m, 2H) IR(KBr)3423, 1716, 1610, 1519, 1481, 1365, 1235, 1177, 1151, 1119, 1080, 876, 798cm⁻¹ I-539 m.p. 144–146° C. ¹HNMR(CDCl₃) δ 2.32(s, 3H), 2.69(s, 3H), 3.14(s, 3H), 3.21(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 5.18(s, 2H), 6.84(s, 1H), 7.14(d, J=8.7Hz, 2H), 7.15(d, J=8.4Hz, 1H), 7.34(dd, J=2.1, 8.4Hz, 1H), 7.38(d, J=8.4Hz, 2H), 7.40(d, J=2.1Hz, 1H), 7.48(d, J=8.7Hz, 2H), 7.67(d, J=8.4Hz, 2H) IR(KBr)1760, 1519, 1481, 1365, 1177, 1151, 1119, 1079, 876, 797cm⁻¹ I-540 m.p. 228–231° C. ¹HNMR(CDCl₃) δ 2.81(s, 3H), 3.20(s, 3H), 3.21(s, 3H), 3.55(s, 3H), 3.78(s, 3H), 5.30(s, 2H), 6.85(s, 1H), 7.11(d, J=8.4Hz, 1H), 7.35(dd, J=2.1, 8.4Hz, 1H), 7.39(d, J=8.4Hz, 2H), 7.41(d, J=2.1Hz, 1H), 7.67(d, J=8.4Hz, 2H), 7.69(d, J=8.7Hz, 2H), 8.28(d, J=8.7Hz, 2H) IR(KBr)1608, 1521, 1481, 1361, 1179, 1148, 1080, 880, 799cm⁻¹

TABLE 108 I-541 m.p. 153–156° C. ¹HNMR(CDCl₃) δ 1.53(s, 9H), 2.69(s, 3H), 3.15(s, 3H), 3.21(s, 3H), 3.55(s, 3H), 3.78(s, 3H), 5.19(s, 2H), 6.84(s, 1H), 7.10(dd, J=7.5, 7.5Hz, 1H), 7.17(d, J=7.5Hz, 1H), 7.23(d, J=8.4Hz, 1H), 7.26(dd, J=7.5, 7.5Hz, 1H), 7.33(d, J=7.5Hz, 1H), 7.37(dd, J=2.1, 8.4Hz, 1H), 7.38 (d, J=8.4Hz, 2H), 7.40(d, J=2.1Hz, 1H), 7.67(d, J=8.4Hz, 2H) IR(KBr)3405, 1724, 1519, 1480, 1366, 1236, 1177, 1153, 1080, 970, 875, 798cm⁻¹ I-542 m.p. 178–182° C. ¹HNMR(CDCl₃) δ 2.70(s, 3H), 3.15(s, 3H), 3.21(s, 3H), 3.55(s, 3H), 3.78(s, 3H), 5.14(s, 2H), 6.76(m, 2H), 6.84(s, 1H), 7.19(m, 2H), 7.26 (d, J=8.7Hz, 1H), 7.37(d, J=2.7Hz, 1H), 7.36(dd, J=2.7, 8.7Hz, 1H), 7.38(d, J=8.7Hz, 2H), 7.68(d, J=8.7Hz, 2H) IR(KBr)3448, 1627, 1608, 1519, 1497, 1364, 1177, 1151, 1079, 971, 876, 798cm⁻¹ I-543 m.p. 187–189° C. ¹HNMR(CDCl₃) δ 2.38(s, 3H), 3.39(s, 3H), 3.45(s, 3H), 5.11–5.14(m, 3H), 5.89(s, 1H), 6.33(s, 1H), 6.88–6.94(m, 2H), 7.20–7.36(m, 6H), 7.43(d, J=2.1Hz, 1H), 7.76(d, J=0.6Hz, 1H) IR(KBr)3414, 2942, 1613, 1534, 1469, 1355, 1266, 1172, 1092, 1030cm⁻¹ I-544 m.p. 207–215° C.(dec.) ¹HNMR(d6-DMSO) δ 2.37(s, 3H), 3.67(brs, 2H), 4.56(brs, 2H), 4.90(s, 2H), 6.14–6.20(m, 2H), 6.86(d, J=8.7Hz, 2H), 7.11–7.22(m, 4H), 7.42(d, J=8.7Hz, 2H), 7.52(s, 1H), 8.94(s, 1H), 9.47(s, 1H) IR(KBr)3388, 3301, 2932, 1612, 1591, 1521, 1458, 1413, 1288, 1030cm⁻¹ I-545 m.p. 108–110° C. ¹HNMR(CDCl₃) δ 1.69(s, 3H), 1.74(s, 3H), 2.49–2.59(m, 2H), 3.03(s, 3H), 3.20(s, 3H), 3.56(s, 3H), 3.75(s, 3H), 4.06(t, J=6.6Hz, 2H), 4.93 (s, 2H), 5.22(m, 1H), 6.66(s, 1H), 7.04(d, J=8.7Hz, 1H), 7.09–7.17(m, 2H), 7.37(dd, J=2.1, 8.7Hz, 1H), 7.44(d, J=2.1Hz, 1H), 7.51–7.58 (m, 2H) IR(KBr)3434, 2933, 1604, 1521, 1473, 1383, 1360, 1278, 1160, 1121, 1084, 1017cm⁻¹

TABLE 109 I-546 m.p. 109–110° C. ¹HNMR(CDCl₃) δ 1.69(s, 3H), 1.75(s, 3H), 2.48–2.58(m, 2H), 4.07(t, J=6.6Hz, 2H), 5.22(m, 1H), 5.69(s, 1H), 5.87(s, 1H), 6.44(s, 1H), 6.93–6.95(m, 2H), 7.04–7.06(m, 1H), 7.10–7.18(m, 2H), 7.58–7.64(m, 2H) IR(KBr)3411, 2932, 1608, 1587, 1522, 1491, 1226, 1111, 1074, 1017cm⁻¹ I-547 m.p. 141–142° C. ¹HNMR(CDCl₃) δ 3.03(s, 3H), 3.57(s, 3H), 3.75(s, 3H), 4.90(s, 2H), 5.16(s, 2H), 5.65(brs, 1H), 6.66(s, 1H), 6.92(dd, J=1.8, 8.4Hz, 1H), 6.99(d, J=8.4Hz, 1H), 7.06(d, J=1.8Hz, 1H), 7.10–7.17(m, 2H), 7.35–7.47(m, 5H), 7.52–7.59(m, 2H) IR(KBr)3529, 3439, 2932, 1601, 1518, 1477, 1461, 1380, 1251, 1224, 1157, 1113, 1094, 1076cm⁻¹ I-548 m.p. 133–136° C. ¹HNMR(CDCl₃) δ 2.98(s, 3H), 3.12(s, 3H), 3.56(s, 3H), 3.75(s, 3H), 4.94(s, 2H), 5.18(s, 2H), 6.67(s, 1H), 7.09–7.17(m, 3H), 7.34–7.49 (m, 7H), 7.51–7.58(m, 2H) IR(KBr)3434, 2941, 1598, 1519, 1481, 1383, 1365, 1279, 1231, 1164, 1099, 1081cm⁻¹ I-549 m.p. 161–162° C. ¹HNMR(CDCl₃) δ 3.10(s, 3H), 3.42(s, 3H), 3.76(s, 3H), 5.17(s, 2H), 6.05(s, 1H), 6.44(s, 1H), 7.11–7.20(m, 3H), 7.33–7.50(m, 7H), 7.52 (d, J=2.1Hz, 1H), 7.57–7.65(m, 2H) IR(KBr)3488, 2938, 1613, 1523, 1486, 1290, 1223, 1107, 1071, 1012cm⁻¹ I-550 m.p. 113–115° C. ¹HNMR(CDCl₃) δ 2.37(s, 3H), 2.98(s, 3H), 3.11(s, 3H), 3.56(s, 3H), 3.75(s, 3H), 4.93(s, 2H), 5.13(s, 2H), 6.66(s, 1H), 7.09–7.17(m, 3H), 7.18–7.23(m, 2H), 7.32–7.39(m, 3H), 7.45(d, J=1.8Hz, 1H), 7.51–7.58(m, 2H) IR(KBr)3434, 2934, 1738, 1601, 1520, 1478, 1466, 1376, 1356, 1236, 1159, 1109, 1070, 1014cm⁻¹

TABLE 110 I-551 m.p. 138–140° C. ¹HNMR(CDCl₃) δ 2.38(s, 3H), 3.04(s, 3H), 3.57(s, 3H), 3.74(s, 3H), 4.90(s, 2H), 5.11(s, 2H), 5.63(s, 1H), 6.66(s, 1H), 6.91(dd, J=2.1, 8.4Hz, 1H), 6.99(d, J=8.4Hz, 1H), 7.05(d, J=1.8Hz, 1H), 7.08–7.17(m, 2H), 7.22(d, J=7.8Hz, 2H), 7.33(d, J=7.8Hz, 2H), 7.52–7.59(m, 2H) IR(KBr)3446, 2934, 1601, 1518, 1476, 1461, 1379, 1252, 1224, 1158, 1092, 1011cm⁻¹ I-552 m.p. 188–190° C. ¹HNMR(CDCl₃) δ 2.38(s, 3H), 3.10(s, 3H), 3.42(s, 3H), 3.75(s, 3H), 5.12(s, 2H), 6.04(s, 1H), 6.43(s, 1H), 7.11–7.25(m, 5H), 7.35(d, J=7.8Hz, 2H), 7.42(dd, J=2.4, 8.7Hz, 1H), 7.51(d, J=2.4Hz, 1H), 7.57–7.65(m, 2H) IR(KBr)3433, 2963, 1611, 1523, 1485, 1355, 1282, 1226, 1163, 1106, 1071cm⁻¹ I-553 m.p. 149–150° C. ¹HNMR(CDCl₃) δ 3.13(s, 3H), 3.21(s, 3H), 5.20(s, 2H), 7.17(d, J=8.4Hz, 1H), 7.24(m, 1H), 7.36–7.54(m, 9H), 7.58(dd, J=1.2, 2.4Hz, 1H), 7.60–7.67(m, 2H) IR(KBr)1524, 1485, 1354, 1292, 1263, 1181, 1150, 1114, 977, 869, 858, 850, 812, 796cm⁻¹ I-554 m.p. 92–93° C. ¹HNMR(CDCl₃) δ 1.69(s, 3H), 1.74(d, J=1.2Hz, 3H), 2.25(s, 3H), 2.28(s, 3H), 2.56(dt, J=6.6, 7.2Hz, 2H), 3.20(s, 3H), 3.21(s, 3H), 4.07 (t, J=7.2Hz, 2H), 5.22(m, 1H), 7.05(d, J=8.4Hz, 1H), 7.11(s, 1H), 7.13(s, 1H), 7.25(dd, J=2.1, 8.4Hz, 1H), 7.31–7.43(m, 5H) IR(KBr) 1518, 1488, 1355, 1293, 1264, 1169, 1151, 1109, 970, 872, 818cm⁻¹ I-555 m.p. 126–127° C. ¹HNMR(CDCl₃) δ 1.77(s, 3H), 1.82(s, 3H), 3.20(s, 3H), 3.23(s, 3H), 4.65(d, J=6.6Hz, 2H), 5.50(m, 1H), 7.10(d, J=8.7Hz, 1H), 7.18–7.27 (m, 2H), 7.36–7.43(m, 2H), 7.50(dd, J=1.5, 8.7Hz, 1H), 7.55(d, J=1.5Hz, 1H), 7.60–7.66(m, 2H) IR(KBr)1527, 1489, 1359, 1295, 1266, 1177, 1153, 1118, 974, 894, 874cm⁻¹

TABLE 111 I-556 m.p. 154–155° C. ¹HNMR(CDCl₃) δ 2.25(s, 3H), 2.28(s, 3H), 2.38(s, 3H), 3.11(s, 3H), 3.20(s, 3H), 5.13(s, 2H), 7.11(s, 1H), 7.14(s, 1H), 7.19–7.28(m, 4H), 7.31–7.43(m, 7H) IR(KBr)1520, 1487, 1365, 1284, 1260, 1192, 1172, 1152, 1108, 967, 867, 809, 795cm⁻¹ I-557 m.p. 112–113° C. ¹HNMR(CDCl₃) δ 1.69(s, 3H), 1.76(s, 3H), 2.26(s, 3H), 2.27(s, 3H), 2.54(dt, J=7.2, 6.9Hz, 2H), 4.07(t, J=6.9Hz, 2H), 4.86(s, 1H), 5.23 (m, 1H), 5.71(s, 1H), 6.82(dd, J=2.1, 8.4Hz, 1H), 6.85–6.93(m, 3H), 6.96(d, J=2.1Hz, 1H), 7.10(s, 1H), 7.12(s, 1H), 7.22–7.27(m, 2H) IR(KBr)3380, 1613, 1586, 1523, 1490, 1471, 1431, 1391, 1293, 1261, 1246, 1205, 1171, 1130, 836cm⁻¹ I-558 m.p. 141–142° C. ¹HNMR(CDCl₃) δ 1.77(s, 3H), 1.82(s, 3H), 4.63(d, J=6.9Hz, 2H), 5.06(s, 1H), 5.52(m, 1H), 5.75(s, 1H), 6.89–6.97(m, 3H), 7.07(dt, J=8.4, 1.8Hz, 1H), 7.14–7.23(m, 3H), 7.44–7.51(m, 2H) IR(KBr)3429, 1612, 1594, 1531, 1489, 1467, 1449, 1401, 1259, 1213, 1169, 1132, 835, 781cm⁻¹ I-559 m.p. 179–180° C. ¹HNMR(CDCl₃) δ 2.26(s, 3H), 2.28(s, 3H), 2.39(s, 3H), 4.81(s, 1H), 5.11(s, 2H), 5.70(s, 1H), 6.83(dd, J=2.1, 8.4Hz, 1H), 6.86–6.91(m, 2H), 6.98(d, J=8.4Hz, 1H), 6.98(d, J=2.1Hz, 1H), 7.10(s, 1H), 7.12(s, 1H), 7.21–7.28(m, 4H), 7.32–7.38(m, 2H) IR(KBr)3317, 1609, 1520, 1489, 1426, 1378, 1247, 1206, 1175, 1124, 1006, 792cm⁻¹ I-560 foam ¹HNMR(DMSO-d₆) δ 3.74(s, 3H), 3.75(s, 3H), 4.62(d, J=5.0Hz, 2H), 5.02(t, J=5.0Hz, 1H), 5.19(s, 2H), 6.94(s, 1H), 6.99(s, 1H), 7.06(d, J=8.0Hz, 1H), 7.22(ddd, J=8.6, 2.0, 0.8Hz, 1H), 7.32–7.52(m, 8H), 7.57(d, J=2.4Hz, 1H), 9.91(brs, 1H) IR(KBr)3257, 1525, 1491, 1464, 1453, 1382, 1207, 1035, 764, 737cm⁻¹

TABLE 112 I-561 m.p. 147–148° C. ¹HNMR(CDCl₃) δ 3.27(s, 3H), 3.79(s, 3H), 3.82(s, 3H), 5.26(s, 2H), 6.92(s, 1H), 6.95(s, 1H), 7.13(d, J=8.7Hz, 1H), 7.35–7.50(m, 8H), 7.80 (dd, J=8.7, 2.7Hz, 1H), 8.05(d, J=2.7Hz, 1H), 10.62(s, 1H) IR(KBr)1682, 1606, 1489, 1377, 1345, 1261, 1209, 1168, 1119, 1038, 871, 832cm⁻¹ I-562 m.p. 189–191° C. ¹HNMR(DMSO-d₆) δ 3.53(s, 3H), 3.80(s, 3H), 3.80(s, 3H), 5.27(s, 2H), 7.05(s, 1H), 7.10(s, 1H), 7.25(d, J=8.7Hz, 1H), 7.30–7.59(m, 7H), 7.66(dd, J=11.7, 2.1Hz, 1H), 7.67(dd, J=8.7, 2.3Hz, 1H), 7.84(d, J=2.3Hz, 1H), 12.7(brs, 1H) IR(KBr)3433, 1705, 1492, 1371, 1250, 1207, 1168, 1033, 868cm⁻¹ I-563 m.p. 204–207° C. ¹HNMR(CDCl₃) δ 1.36(s, 9H), 3.20(s, 3H), 3.41(s, 3H), 3.74(s, 3H), 5.15(s, 2H), 5.65(s, 1H), 5.77(s, 1H), 6.80(s, 1H), 6.83(dd, J=8.4, 2.0Hz, 1H), 6.96(d, J=2.0Hz, 1H), 6.98(d, J=8.4Hz, 1H), 7.34–7.45(m, 7H), 7.68(d, J=8.7Hz, 2H) IR(KBr)3408, 3337, 1692, 1498, 1474, 1466, 1347, 1251, 1150, 870, 855cm⁻¹ I-564 m.p. 179–182° C. ¹HNMR(DMSO-d₆) δ 3.76(s, 3H), 3.76(s, 3H), 5.26(s, 2H), 6.99(s, 1H), 7.00(t, J=8.7Hz, 1H), 7.01(s, 1H), 7.22(ddd, J=8.7, 2.4Hz, J=1.2Hz, 1H), 7.24(d, J=8.9Hz, 1H), 7.32–7.54(m, 6H), 7.65(dd, J=8.9, 2.4Hz, 1H), 7.82(d, J=2.4Hz, 1H), 9.91(s, 1H), 12.6(brs, 1H) IR(KBr)3422, 3277, 1726, 1526, 1491, 1416, 1396, 1284, 1210, 1031cm⁻¹ I-565 m.p. 178–180° C. ¹HNMR(DMSO-d₆) δ 3.30(s, 3H), 3.43(s, 3H), 3.61(s, 3H), 4.31(s, 2H), 5.14(s, 2H), 6.25(s, 1H), 6.61(dd, J=8.4, 1.9Hz, 1H), 7.05(d, J=8.4Hz, 1H), 7.33–7.44(m, 6H), 7.50–7.54(m, 2H), 7.70(d, J=8.7Hz, 2H), 9.08(s, 1H) IR(KBr)3435, 3378, 1593, 1518, 1481, 1360, 1245, 1147, 1119, 1010, 871cm⁻¹

TABLE 113 I-566 foam ¹HNMR(DMSO-d₆) δ 3.27(s, 3H), 3.59(s, 3H), 4.21(s, 2H), 5.13(s, 2H), 6.17(s, 1H), 6.60(dd, J=8.3, 1.4Hz, 1H), 6.70(d, J=1.4Hz, 1H), 6.82 (d, J=8.4Hz, 2H), 7.03(d, J=8.3Hz, 1H), 7.33–7.53(m, 7H), 9.07(brs, 1H), 9.45(brs, 1H) IR(KBr)3390, 1609, 1592, 1522, 1484, 1247, 1227, 1119, 1011, 812cm⁻¹ I-567 m.p. 146–148° C. ¹HNMR(DMSO-d₆) δ 1.64(s, 3H), 1.70(s, 3H), 2.44(q, J=6.9Hz, 2H), 3.53(s, 3H), 3.78(s, 3H), 3.80(s, 3H), 4.05(t, J=6.9Hz, 2H), 5.26(t, J=6.9Hz, 2H), 7.05(s, 1H), 7.10(s, 1H), 7.19(d, J=8.4Hz, 1H), 7.50(dd, J=8.4, 2.0Hz, 1H), 7.57(t, J=8.3Hz, 1H), 7.65(ddd, J=8.3, 1.9, 0.9Hz, 1H), 7.66(dd, J=11.9, 1.9Hz, 1H), 7.79(d, J=2.0Hz, 1H), 12.5(brs, 1H) IR(KBr)3434, 3299, 1727, 1489, 1375, 1341, 1209, 1172, 1033, 851, 824cm⁻¹ I-568 m.p. 179–181° C. ¹HNMR(CDCl₃) δ 1.31(s, 9H), 3.11(s, 3H), 3.20(s, 3H), 3.39(s, 3H), 3.74(s, 3H), 5.16(s, 2H), 5.98(s, 1H), 6.79(s, 1H), 7.09(d, J=8.5Hz, 1H), 7.29(dd, J=8.5, 1.9Hz, 1H), 7.35–7.49(m, 8H), 7.66(d, J=8.7Hz, 2H) IR(KBr)3404, 3341, 1690, 1517, 1465, 1369, 1348, 1174, 1151, 869, 814cm⁻¹ I-569 m.p. 189–191° C. ¹HNMR(DMSO-d₆) δ 3.31(s, 3H), 3.33(s, 3H), 3.43(s, 3H), 3.64(s, 3H), 4.48(s, 2H), 5.25(s, 2H), 6.28(s, 1H), 7.24(dd, J=9.0, 2.0Hz, 1H), 7.24(d, J=2.0Hz, 1H), 7.34–7.46(m, 6H), 7.52–7.55(m, 2H), 7.70(d, J=9.0Hz, 2H) IR(KBr)3490, 3392, 1596, 1518, 1483, 1364, 1150, 872, 813cm⁻¹ I-570 m.p. 194–196° C. ¹HNMR(CDCl₃) δ 3.07(s, 3H), 3.22(s, 3H), 3.36(s, 3H), 3.77(s, 3H), 5.16(s, 2H), 6.92(s, 1H), 7.13(d, J=8.6Hz, 1H), 7.25(dd, J=8.6, 2.1Hz, 1H), 7.29(d, J=2.1Hz, 1H), 7.36–7.47(m, 7H), 7.63(brs, 1H), 7.67(d, J=8.4Hz, 2H) IR(KBr)3433, 3329, 1737, 1518, 1476, 1369, 1168, 1148, 878cm⁻¹

TABLE 114 I-571 m.p. 184–186° C. ¹HNMR(CDCl₃) δ 2.31(s, 3H), 2.38(s, 3H), 3.12(s, 3H), 3.45(s, 3H), 3.58(s, 3H), 3.76(s, 3H), 5.14(s, 2H), 6.95(s, 1H), 7.11–7.23(m, 5H), 7.34–7.37(m, 4H), 7.57(dd, J=8.7, 2.4Hz, 1H), 7.66(d, J=2.4Hz, 1H) IR(CHCl₃)2952, 1732, 1614, 1599, 1518, 1467, 1445, 1370, 1290, 1256, 1169, 1117, 1081, 1064, 1003, 973, 905, 827cm⁻¹ I-572 m.p. 218–220° C. ¹HNMR(CDCl₃) δ 2.38(s, 3H), 3.12(s, 3H), 3.44(s, 3H), 3.63(s, 3H), 3.76(s, 3H), 5.14(s, 2H), 6.80–6.83(m, 2H), 6.94(s, 1H), 7.14(d, J=8.7Hz, 1H), 7.21–7.23(m, 4H), 7.35–7.37(m, 2H), 7.56(dd, J=8.7, 2.4Hz, 1H), 7.66(d, J=2.4Hz, 1H) IR(CHCl₃)3596, 2939, 1720, 1613, 1522, 1466, 1445, 1370, 1346, 1291, 1258, 1183, 1172, 1116, 1081, 1064, 1003, 973, 904, 866, 837cm⁻¹ I-573 m.p. 197–199° C. ¹HNMR(CD₃OD) δ 3.19(s, 3H), 3.43(s, 3H), 3.76(s, 3H), 5.25(s, 2H), 7.06–7.12(m, 3H), 7.32–7.43(m, 6H), 7.52–7.54 (m, 2H), 7.60(dd, J=8.4, 2.4Hz, 1H), 7.66(d, J=2.4Hz, 1H) IR(KBr)3421, 2941, 1738, 1708, 1643, 1519, 1472, 1354, 1297, 1259, 1228, 1171, 1119, 1081, 1063, 1001, 958, 920, 871, 826, 755, 697, 524cm⁻¹ I-574 m.p. 151–153° C. ¹HNMR(CDCl₃) δ 2.39(s, 3H), 3.44(s, 3H), 3.64(s, 3H), 3.74(s, 3H), 5.12(s, 2H), 5.78(br, 2H), 6.78–6.81(m, 2H), 6.94(s, 1H), 6.99(d, J=8.4Hz, 1H), 7.15–7.25(m, 6H), 7.33–7.36(m, 2H) IR(CHCl₃)3595, 3541, 2952, 1730, 1612, 1591, 1521, 1474, 1395, 1345, 1323, 1290, 1258, 1173, 1129, 1081, 1063, 1004, 901, 863, 836cm⁻¹ I-575 m.p. 195–196° C. ¹HNMR(CD₃OD) δ 2.34(s, 3H), 3.40(s, 3H), 3.72(s, 3H), 5.16(s, 2H), 6.75–6.78(m, 2H), 6.96(s, 1H), 7.02(s, 1H), 7.14–7.21(m, 6H), 7.36–7.39 (m, 2H) IR(KBr)3530, 3398, 2942, 1708, 1610, 1593, 1520, 1465, 1373, 1334, 1256, 1233, 1127, 1078, 1056, 996, 960, 864, 834, 791, 755, 690, 651, 605, 534cm⁻¹

TABLE 115 I-576 m.p. 82–84° C. ¹HNMR(CDCl₃) δ 1.70(s, 3H), 1.75(s, 3H), 2.54–2.59(m, 2H), 3.24(s, 3H), 3.50(s, 3H), 3.77(s, 3H), 4.10(t, J=6.9Hz, 2H), 5.23(m, 1H), 7.07– 7.12 (m, 4H), 7.23–7.28(m, 2H), 7.57(dd, J=8.7, 2.4Hz, 1H), 7.63(d, J=2.4Hz, 1H), 9.99(s, 1H) IR(CHCl₃)2936, 1697, 1604, 1591, 1518, 1469, 1445, 1371, 1331, 1294, 1232, 1172, 1159, 1123, 1093, 1005, 964cm⁻¹ I-577 m.p. 126–128° C. ¹HNMR(CD₃OD) δ 1.70(s, 3H), 1.74(d, J=0.9Hz, 3H), 2.53–2.61(m, 2H), 3.25(s, 3H), 3.44(s, 3H), 3.75(s, 3H), 4.13(t, J=6.3Hz, 2H), 5.29 (m, 1H), 7.04–7.11(m, 3H), 7.24(d, J=8.7Hz, 1H), 7.33–7.38(m, 2H), 7.58–7.65(m, 2H) IR(KBr)3432, 2940, 2566, 1735, 1711, 1646, 1613, 1519, 1470, 1447, 1366, 1297, 1264, 1228, 1172, 1118, 1081, 1063, 1001, 962, 920, 898, 871, 828, 796, 695, 524cm⁻¹ I-578 m.p. 202–204° C. ¹HNMR(CDCl₃) δ 3.13(s, 3H), 3.45(s, 3H), 3.61(s, 3H), 3.76(s, 3H), 5.19(s, 2H), 6.95(s, 1H), 7.05–7.11(m, 2H), 7.14(d, J=8.7Hz, 1H), 7.30– 7.49 (m, 7H), 7.57(dd, J=8.7, 2.4Hz, 1H), 7.67(d, J=2.4Hz, 1H) IR(CHCl₃)2952, 1731, 1603, 1519, 1472, 1445, 1371, 1345, 1291, 1172, 1159, 1117, 1081, 1064, 1004, 972, 960, 904cm⁻¹ I-579 m.p. 197–199° C. ¹HNMR(CDCl₃) δ 2.71(s, 3H), 3.56, (s, 3H), 3.75(s, 3H), 5.18(s, 2H), 5.72, (s, 1H), 6.86(s, 1H), 7.00(d, J=8.4Hz, 1H), 7.12–7.18(m, 3H), 7.24 (d, J=2.1Hz, 1H), 7.38–7.46(m, 7H) IR(CHCl₃)3543, 2939, 1602, 1521, 1482, 1465, 1394, 1370, 1328, 1254, 1178, 1159, 1130, 1081, 1005, 964, 840, 816cm⁻¹ I-580 m.p. 199–201° C. ¹HNMR(CD₃OD) δ 3.40(s, 3H), 3.73(s, 6H), 5.22(s, 2H), 7.00(s, 1H), 7.03–7.11(m, 4H), 7.17(m, 1H), 7.31–7.41(m, 5H), 7.49–7.52(m, 2H) IR(KBr)3527, 3434, 2940, 1701, 1591, 1518, 1465, 1380, 1335, 1320, 1291, 1270, 1222, 1161, 1130, 1078, 1056, 1002, 916, 868, 837, 747, 698, 633, 599, 526, 480cm⁻¹

TABLE 116 I-581 m.p. 122–123° C. ¹HNMR(CDCl₃) δ 1.78(s, 3H), 1.82(s, 3H), 3.25(s, 3H), 3.50(s, 3H), 3.76(s, 3H), 4.66(d, J=6.9Hz, 2H), 5.52(m, 1H), 7.09–7.14(m, 4H), 7.23–7.27(m, 2H), 7.56(dd, J=8.7, 2.1Hz, 1H), 7.63(d, J=2.1Hz, 1H), 9.99(s, 1H) IR(CHCl₃)2938, 1679, 1604, 1591, 1517, 1469, 1445, 1371, 1331, 1292, 1172, 1159, 1122, 1092, 1004, 973cm⁻¹ I-582 m.p. 158–159° C. ¹HNMR(CDCl₃) δ 2.69(s, 3H), 3.13(s, 3H), 3.57(s, 3H), 3.76(s, 3H), 5.19(s, 2H), 6.85(s, 1H), 7.13–7.18(m, 3H), 7.37–7.49(m, 7H), 7.56 (dd, J=9.0, 2.1Hz, 1H), 7.62(d, J=2.1Hz, 1H) IR(CHCl₃)2939, 1603, 1521, 1482, 1464, 1294, 1253, 1177, 1119, 1082, 1003, 963, 876, 842cm⁻¹ I-583 m.p. 145–147° C. ¹HNMR(CDCl₃) δ 2.68(s, 3H), 3.54(s, 3H), 3.56(s, 3H), 3.75(s, 3H), 5.21(s, 2H), 5.27(s, 2H), 6.85(s, 1H), 7.00(d, J=8.7Hz, 1H), 7.13–7.23 (m, 3H), 7.33–7.49(m, 8H) IR(CHCl₃)2938, 1731, 1603, 1520, 1482, 1370, 1249, 1178, 1158, 1134, 1081, 1004, 961, 840, 815cm⁻¹ I-584 m.p. 160–162° C. ¹HNMR(CDCl₃) δ 3.47(s, 3H), 3.74(s, 3H), 5.18(s, 2H), 5.72(s, 1H), 6.00(s, 1H), 6.46(s, 1H), 7.01(d, J=8.4Hz, 1H), 7.10–7.19(m, 3H), 7.27 (d, J=2.1Hz, 1H), 7.36–7.48(m, 7H) IR(CHCl₃)3540, 2938, 1603, 1568, 1522, 1490, 1464, 1416, 1396, 1325, 1263, 1158, 1111, 1072, 1002, 838cm⁻¹ I-585 m.p. 133–134° C. ¹HNMR(CD₃OD) δ 1.80(d, J=0.9Hz, 3H), 1.82(d, J=0.9Hz, 3H), 3.26(s, 3H), 3.44(s, 3H), 3.76(s, 3H), 4.71(d, J=6.9Hz, 2H), 5.55(m, 1H), 7.06–7.12(m, 3H), 7.26(d, J=8.7Hz, 1H), 7.34–7.36(m, 2H), 7.58–7.63(m, 2H) IR(KBr)3422, 2939, 1736, 1702, 1603, 1519, 1472, 1368, 1293, 1228, 1187, 1173, 1117, 1081, 1061, 1003, 975, 961, 920, 827, 759, 701, 523cm⁻¹

TABLE 117 I-586 m.p. 152–153° C. ¹HNMR(CDCl₃) δ 1.69(s, 3H), 1.74(d, J=0.9Hz, 3H), 2.55–2.57(m, 2H), 3.23(s, 3H), 3.44(s, 3H), 3.60(s, 3H), 3.77(s, 3H), 4.09(t, J=6.6Hz, 2H), 5.22(m, 1H), 6.95(s, 1H), 7.05–7.11(m, 3H), 7.30–7.35(m, 2H), 7.57(dd, J=8.7, 2.4Hz, 1H), 7.64(d, J=2.4Hz, 1H) IR(CHCl₃)2938, 1731, 1601, 1519, 1469, 1445, 1370, 1345, 1291, 1172, 1159, 1117, 1081, 1064, 1004, 973, 904, 864, 840cm⁻¹ I-587 m.p. 132–133° C. ¹HNMR(CDCl₃) δ 3.44(s, 3H), 3.61(s, 3H), 3.75(s, 3H), 5.18(s, 2H), 5.71(s, 1H), 6.95(s, 1H), 6.99–7.10(m, 3H), 7.17(dd, J=8.4, 2.1Hz, 1H), 7.25–7.47(m, 8H) IR(CHCl₃)3542, 2952, 2938, 1731, 1597, 1519, 1474, 1392, 1345, 1321, 1290, 1266, 1159, 1130, 1080, 1063, 1000, 900, 862, 839cm⁻¹ I-588 m.p. 92–94° C. ¹HNMR(CDCl₃) δ 1.69(d, J=0.6Hz, 3H), 1.76(d, J=1.2Hz, 3H), 2.51–2.58(m, 2H), 3.45(s, 3H), 3.75(s, 3H), 4.09(t, J=6.9Hz, 2H), 5.23 (m, 1H), 5.70(br, 1H), 6.92(d, J=8.4Hz, 1H), 6.97(s, 1H), 7.05–7.10(m, 2H), 7.16(dd, J=8.4, 2.1Hz, 1H), 7.23(d, J=2.1Hz, 1H), 7.33–7.38 (m, 2H) IR(KBr)3534, 3432, 2936, 1713, 1597, 1519, 1473, 1377, 1322, 1260, 1231, 1158, 1130, 1081, 1063, 1004, 961, 919, 837, 808, 791, 754, 705, 521cm⁻¹ I-589 m.p. 120–122° C. ¹HNMR(CDCl₃) δ 1.69(s, 3H), 1.76(s, 3H), 2.51–2.58(m, 2H), 3.44(s, 3H), 3.61(s, 3H), 3.75(s, 3H), 4.09(t, J=6.6Hz, 2H), 5.23(m, 1H), 5.73 (s, 1H), 6.92(d, J=8.4Hz, 1H), 6.96(s, 1H), 7.04–7.10(m, 2H), 7.16(dd, J=8.1, 1.8Hz, 1H), 7.23(d, J=1.8Hz, 1H), 7.31–7.36(m, 2H) IR(CHCl₃)3541, 2937, 1731, 1598, 1519, 1471, 1391, 1345, 1323, 1290, 1265, 1159, 1130, 1080, 1063, 1005, 839cm⁻¹ I-590 m.p. 154–156° C. ¹HNMR(CDCl₃) δ 1.77(s, 3H), 1.82(s, 3H), 3.24(s, 3H), 3.45(s, 3H), 3.61(s, 3H), 3.76(s, 3H), 4.64(d, J=7.2Hz, 2H), 5.51(m, 1H), 6.95(s, 1H), 7.05–7.11(m, 3H), 7.31–7.35(m, 2H), 7.57(dd, J=8.7, 2.4Hz, 1H), 7.64(d, J=2.4Hz, 1H) IR(CHCl₃)2938, 1731, 1602, 1519, 1472, 1445, 1370, 1345, 1290, 1186, 1116, 1080, 1064, 1003, 973, 904, 840cm⁻¹

TABLE 118 I-591 m.p. 181–182° C. ¹HNMR(CD₃OD) δ 1.77(s, 3H), 1.80(d, J=0.9Hz, 3H), 3.42(s, 3H), 3.74(s, 3H), 4.65(d, J=6.9Hz, 2H), 5.55(m, 1H), 6.99–7.11(m, 5H), 7.15 (d, J=2.1Hz, 1H), 7.32–7.36(m, 2H) IR(KBr)3529, 3424, 2937, 1714, 1598, 1519, 1473, 1417, 1372, 1336, 1321, 1258, 1235, 1157, 1129, 1080, 1062, 1004, 989, 917, 854, 839, 807, 791, 752, 703cm⁻¹ I-592 m.p. 109–110° C. ¹HNMR(CDCl₃) δ 1.78(s, 3H), 1.83(s, 3H), 3.44(s, 3H), 3.61(s, 3H), 3.75(s, 3H), 4.63(d, J=6.6Hz, 2H), 5.53(m, 1H), 5.72(s, 1H), 6.94(d, J=8.1Hz, 1H), 6.96(s, 1H), 7.04–7.10(m, 2H), 7.16(dd, J=8.4, 2.1Hz, 1H), 7.23(d, J=2.1Hz, 1H), 7.31–7.36(m, 2H) IR(CHCl₃)3538, 2938, 1731, 1598, 1519, 1473, 1391, 1345, 1290, 1264, 1159, 1129, 1080, 1063, 1004, 900, 862, 839cm⁻¹ I-593 m.p. 185–187° C. ¹HNMR(CDCl₃) δ 3.78(s, 3H), 3.80(s, 3H), 4.82(s, 1H), 6.61(m, 1H), 6.88–6.93(m, 2H), 6.96(s, 1H), 7.04(s, 1H), 7.23–7.25(m, 1H), 7.45 (d, J=0.9Hz, 1H), 7.48–7.53(m, 2H), 7.83(d, J=0.9Hz, 1H), 8.18(brs, 1H) IR(KBr)3600–3200(br), 1611, 1523, 1496, 1464, 1447, 1388, 1268, 1239, 1202, 1046, 1025cm⁻¹ I-594 m.p. 188–189° C. ¹HNMR(CDCl₃) δ 3.19(s, 3H), 3.79(s, 3H), 3.81(s, 3H), 6.61–6.62(m, 1H), 6.96(s, 1H), 7.06(s, 1H), 7.24–7.26(m, 1H), 7.33–7.37(m, 2H), 7.45(brs, 2H), 7.64–7.68(m, 2H), 7.84(d, J=0.9Hz, 1H), 8.21(brs, 1H) IR(KBr)3600–3200(br), 1518, 1494, 1465, 1419, 1389, 1351, 1331, 1314, 1213, 1177, 1145, 1051, 1027cm⁻¹ I-595 m.p. 98–101° C. ¹HNMR(CDCl₃) δ 1.77(s, 3H), 1.78(s, 3H), 1.82(s, 3H), 1.85(s, 3H), 3.78(s, 3H), 3.79(s, 3H), 4.56(d, J=6.9Hz, 2H), 4.72(d, J=6.9Hz, 2H), 5.39–5.44(m, 1H), 5.52–5.57(m, 1H), 6.53(d, J=3.0Hz, 1H), 6.97–7.03(m, 4H), 7.12(d, J=3.3Hz, 1H), 7.38(d, J=8.4Hz, 1H), 7.45(dd, J=1.8, 8.7Hz, 1H), 7.52–7.57(m, 2H), 7.81(d, J=1.5Hz, 1H) IR(KBr)3600–2800(br), 1606, 1498, 1476, 1463, 1382, 1262, 1241, 1206, 1177, 1052, 1030cm⁻¹

TABLE 119 I-596 m.p. 207–210° C. ¹HNMR(CDCl₃) δ 3.19(s, 3H), 3.80(s, 3H), 3.81(s, 3H), 5.50(s, 2H), 6.65(d, J=3.0Hz, 1H), 6.81(d, J=7.8Hz, 1H), 6.96(s, 1H), 7.05(s, 1H), 7.19–7.22(m, 1H), 7.25–7.45(m, 6H), 7.54–7.60(m, 1H), 7.64–7.69(m, 2H), 7.86(brs, 1H), 8.61–8.64(m, 1H) IR(KBr)3600–3200(br), 1496, 1478, 1364, 1347, 1210, 1176, 1155, 1052, 1028cm⁻¹ I-597 m.p. 222–224° C. ¹HNMR(CDCl₃) δ 2.36(s, 3H), 2.53(s, 3H), 3.77(s, 3H), 3.78(s, 3H), 6.69(dd, J=0.9, 4.2Hz, 1H), 6.95(s, 1H), 6.96(s, 1H), 7.23–7.28(m, 2H), 7.31–7.35(m, 2H), 7.51–7.54(m, 3H), 7.59(d, J=3.3Hz, 1H), 7.73(d, J=1.2Hz, 1H), 7.80–7.84(m, 2H), 8.03(d, J=1.2Hz, 1H) IR(KBr)3600–3200(br), 1509, 1487, 1464, 1444, 1366, 1208, 1172, 1129, 1092, 1049, 1028cm⁻¹ I-598 m.p. 126–127° C. ¹HNMR(CDCl₃) δ 1.69(s, 3H), 1.71(d, J=0.9Hz, 3H), 2.56(dt, J=6.6, 6.9Hz, 2H), 3.20(s, 3H), 3.22(s, 3H), 4.08(t, J=6.9Hz, 2H), 5.21(m, 1H), 7.08(d, J=8.4Hz, 1H), 7.18–7.27(m, 2H), 7.36–7.43(m, 2H), 7.50(dd, J=1.8, 8.4Hz, 1H), 7.56(d, J=1.8Hz, 1H), 7.59–7.66(m, 2H) IR(KBr)1528, 1488, 1469, 1395, 1362, 1342, 1297, 1265, 1201, 1176, 1152, 1116, 968, 890, 872, 818cm⁻¹ I-599 m.p. 169–170° C. ¹HNMR(DMSO-d₆) δ 2.32(s, 3H), 3.37(s, 3H), 3.45(s, 3H), 5.23(s, 2H), 7.23(d, J=7.8Hz, 2H), 7.37–7.44(m, 3H), 7.47–7.53(m, 2H), 7.56–7.66 (m, 4H), 7.75(d, J=7.5Hz, 2H) IR(KBr)1525, 1485, 1366, 1355, 1291, 1262, 1181, 1150, 1116, 969, 869, 811cm⁻¹ I-600 m.p. 123–124° C. ¹HNMR(CDCl₃) δ 1.68(s, 3H), 1.75(d, J=0.9Hz, 3H), 2.53(dt, J=7.2, 6.9Hz, 2H), 4.07(t, J=6.9Hz, 2H), 4.91(s, 1H), 5.22(m, 1H), 5.72(s, 1H), 6.89–6.95(m, 2H), 7.07(m, 1H), 7.14–7.22(m, 4H), 7.44–7.51(m, 2H) IR(KBr)3448, 1612, 1593, 1530, 1489, 1475, 1401, 1262, 1212, 1181, 1169, 1132, 839, 779cm⁻¹

TABLE 120 I-601 m.p. 184–185° C. ¹HNMR(DMSO-d₆) δ 2.31(s, 3H), 5.13(s, 2H), 6.85–6.91(m, 2H), 6.97(m, 1H), 7.07(d, J=8.4Hz, 1H), 7.07(d, J=1.8Hz, 1H), 7.20(d, J=8.1Hz, 2H), 7.32–7.48(m, 6H) IR(KBr)3290, 1614, 1529, 1491, 1459, 1449, 1405, 1380, 1267, 1254, 1167, 1132, 783cm⁻¹ I-602 m.p. 141–142° C. ¹HNMR(CDCl₃ ) δ 1.77(s, 3H), 1.82(s, 3H), 3.46(s, 3H), 3.78(s, 3H), 4.56(d, J=6.8Hz, 2H), 5.54(t, J=6.6Hz, 1H), 6.96–7.26(m, 7H), 7.61 (dd, J=5.2, 8.6Hz, 2H), 9.88(s, 1H) IR(KBr)3433, 2955, 2922, 2865, 2833, 1687, 1604, 1515, 1462, 1288, 1258, 1232, 1180, 1160, 1070, 998, 845cm⁻¹ I-603 m.p. 169–170° C. ¹HNMR(CDCl₃) δ 2.38(s, 3H), 3.46(s, 3H), 3.77(s, 3H), 5.07(s, 2H), 7.02–7.38(m, 7H), 7.61(dd, J=5.4, 8.8Hz, 2H), 9.89(brs, 1H) IR(KBr)3433, 2936, 2840, 1698, 1517, 1462, 1251, 1233, 1067, 999, 837cm⁻¹ I-604 m.p. 120–121° C. ¹HNMR(CDCl₃) δ 1.68(s, 3H), 1.74(s, 3H), 2.50–2.57(m, 2H), 3.46(s, 3H), 3.77(s, 3H), 3.98(t, J=7.0Hz, 2H), 5.24(t, J=7.0Hz, 1H), 6.94–7.26 (m, 7H), 7.61(dd, J=5.4, 8.8Hz, 2H), 9.88(brs, 1H) IR(KBr)3435, 2960, 2937, 2876, 1698, 1605, 1516, 1464, 1441, 1379, 1296, 1272, 1233, 1221, 1161, 1073, 1024, 845, 807cm⁻¹ I-605 m.p. 151–152° C. ¹HNMR(DMSO-d₆) δ 1.34(s, 6H), 3.07–3.15(m, 1H), 3.32(s, 3H), 3.67(s, 3H), 3.97–4.08(m, 1H), 4.28–4.34(m, 1H), 6.48(s, 1H), 7.00(d, J=7.8Hz, 2H), 7.22–7.35(m, 4H), 7.66(dd, J=3.2, 6.0Hz, 2H), 8.72(brs, 1H) IR(KBr)3460, 2960, 2935, 1607, 1521, 1488, 1456, 1392, 1244, 1226, 1160, 1122, 1073, 818cm⁻¹ I-606 m.p. 164–165° C. ¹HNMR(DMSO-d₆) δ 2.32(s, 3H), 3.31(s, 3H), 3.66(s, 3H), 5.08(s, 2H), 6.46(s, 1H), 6.99(d, J=5.8Hz, 2H), 7.20–7.38(m, 4H), 7.65(dd, J=3.6, 6.2Hz, 2H), 8.69(brs, 1H) IR(KBr)3367, 2940, 1605, 1519, 1484, 1466, 1449, 1390, 1229, 1181, 1158, 1059, 1006, 987, 831, 817cm⁻¹

TABLE 121 I-607 m.p. 103–104° C. ¹HNMR(DMSO-d₆) δ 1.37(s, 6H), 2.47–2.59(m, 2H), 3.31(s, 3H), 3.66(s, 3H), 3.94–4.05(m, 1H), 4.26–4.34(m, 1H), 6.44(s, 1H), 7.02(d, J=7.6Hz, 2H), 7.18–7.35(m, 4H), 7.64(dd, J=3.4, 6.6Hz, 2H), 8.77(brs, 1H) IR(KBr)3400, 2993, 2961, 2930, 1607, 1522, 1486, 1471, 1454, 1393, 1226, 1123, 1072, 835, 819cm⁻¹ I-608 m.p. 157–158° C. ¹HNMR(DMSO-d₆) δ 1.73(s, 3H), 1.77(s, 3H), 3.31(s, 3H), 3.72(s, 3H), 4.54(d, J=6.9Hz, 2H), 5.47(t, J=7.2Hz, 1H), 6.93(d, J=8.7Hz, 2H), 7.05(s, 1H), 7.19(d, J=9.0Hz, 2H), 7.30–7.36(m, 2H), 7.70(dd, J=5.4, 8.7Hz, 2H) IR(KBr)3406, 2936, 1712, 1608, 1519, 1472, 1444, 1375, 1235, 839cm⁻¹ I-609 m.p. 215–216° C. ¹HNMR(DMSO-d₆) δ 2.34(s, 3H), 3.33(s, 3H), 3.74(s, 3H), 5.09(s, 2H), 7.00–7.07(m, 3H)7.22–7.39(m, 8H), 7.73(dd, J=5.6, 8.0Hz, 2H) IR(KBr)3494, 3289, 2938, 1745, 1698, 1520, 1471, 1461, 1378, 1296, 1239, 1183, 1159, 829cm⁻¹ I-610 m.p. 169–170° C. ¹HNMR(DMSO-d₆) δ 1.64(s, 3H), 1.71(s, 3H), 2.41–2.46(m, 2H), 3.32(s, 3H), 3.73(s, 3H), 3.97(t, J=6.6Hz, 2H), 5.23(t, J=7.2Hz, 1H), 6.93(d, J=8.1Hz, 2H), 7.05(s, 1H), 7.20(d, J=7.2Hz, 2H), 7.30–7.36(m, 2H), 7.70(dd, J=4.5, 7.5Hz, 2H) IR(KBr)3424, 2933, 1701, 1609, 1519, 1471, 1379, 1294, 1248, 1061, 839cm⁻¹ I-611 m.p. 167–168° C. ¹HNMR(CDCl₃) δ 1.75(s, 3H), 1.82(s, 3H), 2.35(s, 6H), 2.45(s, 3H), 3.21(s, 3H), 3.56(s, 3H), 3.70(s, 3H), 4.35(d, J=6.9Hz, 2H), 5.60(t, J= 7.2Hz, 1H), 6.84(s, 1H), 7.08(s, 2H), 7.38(d, J=8.7Hz, 2H), 7.70(d, J=9.0Hz, 2H) IR(KBr)3433, 2932, 1509, 1475, 1376, 1359, 1232, 1177, 1152, 1085, 966, 874, 797cm⁻¹

TABLE 122 I-612 m.p. 175–176° C. ¹HNMR(CDCl₃) δ 2.35(s, 6H), 2.39(s, 3H), 2.49(s, 3H), 3.21(s, 3H), 3.56(s, 3h), 3.79(s, 3H), 4.83(s, 2H), 6.84(s, 1H), 7.10(s, 2H), 7.22(d, J=7.5Hz, 2H), 7.38(d, J=8.4Hz, 4H), 7.70(d, J=9.0Hz, 2H) IR(KBr)3434, 2936, 1510, 1475, 1363, 1229, 1176, 1152, 1083, 964, 871, 803cm⁻¹ I-613 m.p. 138–139° C. ¹HNMR(CDCl₃) δ 1.69(s, 3H), 1.75(s, 3H), 2.33(s, 6H), 2.52–2.55(m, 2H), 3.21(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 3.79(t, J=6.9Hz, 2H), 5.27 (t, J=6.6Hz, 1H), 6.83(s, 3H), 7.08(s, 6H), 7.38(d, J=8.7Hz, 2H), 7.70(d, J=9.0Hz, 2H) IR(KBr)3432, 2939, 1509, 1476, 1448, 1362, 1237, 1172, 1155, 1103, 1081, 963, 873, 800cm⁻¹ I-614 m.p. 89–90° C. ¹HNMR(DMSO-d₆) δ 1.74(s, 3H), 1.77(s, 3h), 3.36(s, 3H), 3.67(s, 3H), 4.22(d, J=3.0Hz, 2H), 4.56(d, J=6.3Hz, 2H), 5.48(t, J=5.7Hz, 1H), 6.93–6.96(m, 3H), 7.11(d, J=8.7Hz, 2H), 7.28–7.34(m, 2H), 7.68(dd, J=6.0, 8.7Hz, 2H) IR(KBr)3528, 3418, 2935, 1608, 1518, 1472, 1233, 1004, 836cm⁻¹ I-615 m.p. 89–90° C. ¹HNMR(DMSO-d₆) δ 2.33(s, 3H), 3.36(s, 3H), 3.67(s, 3H), 4.22(d, J=3.9Hz, 2H), 4.59(t, J=4.2Hz, 1H), 5.09(s, 2H), 6.94(s, 1H), 7.02(d, J=8.4Hz, 2H), 7.22(d, J=8.4Hz, 4H), 7.28–7.39(m, 4H), 7.68(dd, J=5.7, 8.4Hz, 2H) IR(KBr)3485, 2931, 1517, 1473, 1460, 1383, 1243, 1225, 1079, 1014, 1001, 834, 798cm⁻¹ I-616 oil ¹HNMR(DMSO-d₆) δ 1.75(s, 3H), 1.78(s, 3H), 2.47–2.52(m, 2H), 3.39(s, 3H), 3.71(s, 3H), 4.25(d, J=3.3Hz, 2H), 4.49(d, J=6.3Hz, 2H), 5.46(t, J=5.7Hz, 1H), 6.91–6.95(m, 3H), 7.13(d, J=8.4Hz, 2H), 7.24–7.32(m, 2H), 7.67(dd, J=5.7, 8.4Hz, 2H) IR(KBr)3528, 3419, 2935, 1608, 1518, 1472, 1383, 1232, 1004, 837cm⁻¹

TABLE 123 I-617 m.p. 138–139° C. ¹HNMR(DMSO-d₆) δ 1.70(s, 3H), 1.77(s, 3H), 2.24(s, 6H), 3.30(s, 3H), 3.64(s, 3H), 4.31(d, J=6.9Hz, 2H), 5.56(t, J=6.6Hz, 1H), 6.39(s, 1H), 6.84(d, J=8.4Hz, 2H), 6.91(s, 2H), 7.44(d, J=8.4Hz, 2H), 8.50(s, 1H), 9.50(s, 1H) IR(KBr)3400, 2966, 2934, 1609, 1519, 1465, 1444, 1389, 1362, 1269, 1228, 1211, 1194, 1171, 1118, 1089, 1027, 953cm⁻¹ I-618 m.p. 122–123° C. ¹HNMR(DMSO-d₆) δ 2.29(s, 6H), 2.37(s, 3H), 3.30(s, 3H), 3.67(s, 3H), 4.81(s, 2H), 6.43(s, 1H), 6.86(d, J=7.5Hz, 2H), 6.97(s, 2H), 7.27 (d, J=6.9Hz, 2H), 7.42–7.48(m, 2H), 8.54(s, 1H), 9.52(s, 1H) IR(KBr)3483, 3423, 2931, 1735, 1709, 1612, 1520, 1477, 1454, 1411, 1395, 1362, 1224, 1176, 1117, 1089, 1028cm⁻¹ I-619 m.p. 81–82° C. ¹HNMR(DMSO-d₆) δ 1.70(s, 3H), 1.76(s, 3H), 2.18–2.30(m, 2H), 2.27(s, 6H), 3.34(s, 3H), 3.68(s, 3H), 3.80(t, J=4.5Hz, 2H), 5.34(t, J= 5.1Hz, 1H), 6.43(s, 1H), 6.88(d, J=7.5Hz, 2H), 6.94(s, 6H), 7.46–7.50(m, 2H), 8.53(s, 1H), 9.54(s, 1H) IR(KBr)3410, 2930, 1612, 1521, 1479, 1454, 1395, 1361, 1265, 1227, 1174, 1117, 1090, 1028, 825cm⁻¹ I-620 m.p. 161–162° C. ¹HNMR(CDCl₃) δ 1.32(s, 9H), 2.38(s, 3H), 3.10(s, 3H), 3.20(s, 3H), 3.39(s, 3H), 3.74(s, 3H), 5.12(s, 2H), 5.96(s, 1H), 6.79(s, 1H), 7.09 (d, J=8.4Hz, 1H), 7.21(d, J=7.8Hz, 2H), 7.28(dd, J=8.4, 1.8Hz, 1H), 7.33–7.38(m, 5H), 7.67(d, J=8.4Hz, 2H) IR(KBr)3398, 1718, 1518, 1472, 1366, 1173, 1151, 877, 867, 813cm⁻¹ I-621 m.p. 139–141° C. ¹HNMR(CDCl₃) δ 1.33(s, 9H), 1.68(s, 3H), 1.74(s, 3H), 2.54(q, J=6.9Hz, 2H), 3.19(s, 3H), 3.20(s, 3H), 3.39(s, 3H), 3.73(s, 3H), 4.05(t, J= 6.9Hz, 2H), 5.21(t, J=6.9Hz, 1H), 5.95(s, 1H), 6.79(s, 1H), 7.02(d, J=8.4Hz, 1H), 7.29(dd, J=8.4, 1.9Hz, 1H), 7.33(d, J=1.9Hz, 1H), 7.36 (d, J=8.7Hz, 2H), 7.66(d, J=8.7Hz, 2H) IR(KBr)3416, 1720, 1519, 1469, 1365, 1237, 1152, 1117, 975, 872, 815cm⁻¹

TABLE 124 I-622 m.p. 197–199° C. ¹HNMR(DMSO-d₆) δ 2.33(s, 3H), 3.31(s, 6H), 3.43(s, 3H), 3.64(s, 3H), 3.74(s, 3H), 4.47(s, 2H), 5.19(s, 2H), 6.28(s, 1H), 7.21–7.25(m, 4H), 7.35(d, J=8.7Hz, 1H), 7.40–7.44(m, 4H), 7.70(d, J=9.0Hz, 2H) IR(KBr)3482, 3385, 1597, 1519, 1484, 1368, 1353, 1150, 872, 813cm⁻¹ I-623 m.p. 99–101° C. ¹HNMR(DMSO-d₆) δ 2.32(s, 3H), 3.27(s, 3H), 3.59(s, 3H), 4.21(s, 2H), 5.08(s, 2H), 6.17(s, 1H), 6.58(dd, J=8.0, 1.8Hz, 1H), 6.69(d, J=1.8Hz, 1H), 6.82(d, J=8.7Hz, 2H), 7.01(d, J=8.0Hz, 1H), 7.21(d, J=7.8Hz, 2H), 7.39(d, J=7.8Hz, 2H), 7.41(d, J=8.7Hz, 2H), 9.02(brs, 1H), 9.45(brs, 1H) IR(KBr)3390, 1609, 1592, 1521, 1484, 1246, 1227, 1117, 1011, 810cm⁻¹ I-624 m.p. 215–217° C. ¹HNMR(CDCl₃ + CD₃OD)d3.78(s, 3H), 3.79(s, 3H), 5.49(s, 2H), 6.64(dd, J=0.6, 2.7Hz, 1H), 6.79(d, J=8.1Hz, 1H), 6.90(d, J=8.7Hz, 2H), 6.96(s, 1H), 7.02(s, 1H), 7.19–7.32(m, 3H), 7.40–7.50(m, 3H), 7.56–7.60(m, 1H), 7.85(d, J=0.9Hz, 1H), 8.58–8.60(m, 1H) IR(KBr)3600–2600(br), 1611, 1599, 1500, 1477, 1445, 1395, 1264, 1238, 1210, 1052, 1029, 1008cm⁻¹ I-625 m.p. 213–214° C. ¹HNMR(CDCl₃) δ 2.36(s, 3H), 3.77(s, 6H), 6.70(dd, J=0.6, 3.6Hz, 1H), 6.93(s, 1H), 6.96(s, 1H), 7.08–7.16(m, 2H), 7.24–7.28(m, 2H), 7.51–7.60(m, 4H), 7.73(d, J=1.5Hz, 1H), 7.80–7.84(m, 2H), 8.03(d, J=9.0Hz, 1H) IR(KBr)3600–2800(br), 1597, 1517, 1496, 1464, 1444, 1372, 1209, 1189, 1172, 1157, 1121, 1092, 1050, 1028cm⁻¹ I-626 ¹HNMR(CDCl₃ + CD₃OD) δ 3.13(s, 3H), 3.81(s, 3H), 3.82(s, 3H), 5.19(s, 2H), 6.97(s, 1H), 6.99(s, 1H), 7.14(d, J=8.7Hz, 1H), 7.34–7.52 (m, 6H), 7.61(d, J=2.1Hz, 1H), 7.73(d, J=8.4Hz, 2H), 8.12(d, J=8.4Hz, 2H) IR(KBr)3432, 1616, 1520, 1494, 1452, 1388, 1352, 1282, 1261, 1211, 1186, 1175, 1113, 1058, 1033cm⁻¹ I-627 ¹HNMR(CDCl₃) δ 3.81(s, 6H), 5.17(s, 2H), 6.99(s, 1H), 7.00(d, J=8.4Hz, 1H), 7.09(dd, J=8.4& 1.8Hz, 1H), 7.23(d, J=1.8Hz, 1H), 7.33–7.50(m, 5H), 7.76(.d, J=8.4Hz, 2H), 8.10(d, J=8.4Hz, 2H) IR(KBr)3551, 3520, 3399, 1615, 1587, 1576, 1521, 1488, 1455, 1383, 1268, 1245, 1208, 1126, 1055, 1034, 1003cm⁻¹

TABLE 125 I-628 ¹HNMR(CDCl₃) δ 3.05(s, 3H), 3.47(s, 3H), 3.75(s, 3H), 5.15(s, 2H), 6.45(s, 1H), 6.94(dd, J=8.4&1.8Hz, 1H), 7.03(d, J=8.4Hz, 1H), 7.06 (d, J=1.8Hz, 1H), 7.30(d, J=8.1Hz, 2H), 7.36–7.51(m, 5H), 7.63(d, J=8.1Hz, 2H) IR(KBr)3525, 3472, 1609, 1588, 1522, 1487, 1455, 1407, 1321, 1286, 1242, 1148, 1115, 1071, 1013cm⁻¹ I-629 ¹HNMR(CDCl₃) δ 2.68(s, 3H), 3.07(s, 3H), 3.14(s, 3H), 3.55(s, 3H), 3.78(s, 3H), 5.19(s, 2H), 6.85(s, 1H), 7.16(d, J=8.7Hz, 1H), 7.27–7.50 (m, 9H), 7.62(d, J=9.0Hz, 2H) IR(KBr)3432, 1611, 1522, 1482, 1462, 1392, 1358, 1295, 1233, 1178, 1154, 1119, 1082, 1012cm⁻¹ I-630 ¹HNMR(CDCl₃) δ 2.88(s, 3H), 3.08(s, 3H), 3.28(s, 3H), 3.30(s, 3H), 3.54(s, 3H), 3.79(s, 3H), 6.87(s, 1H), 7.32(d, J=8.4Hz, 2H), 7.43(d.d, J=8.4&2.1Hz, 1H), 7.54–7.65(m, 4H) IR(KBr)3432, 1612, 1519, 1481, 1367, 1332, 1232, 1177, 1154, 1077, 1011cm⁻¹ I-631 ¹HNMR(CDCl₃) δ 1.57(s, 3H), 169(s, 3H), 2.66(s, 3H), 2.97(s, 3H), 3.13(s, 3H), 3.54(s, 3H), 3.77(s, 3H), 4.31(d, J=7.2Hz, 2H), 5.19(s, 2H), 5.21–5.32(m, 1H), 6.86(s, 1H), 7.15(.d, J=8.7Hz, 1H), 7.30–7.52(m, 9H), 7.63(d, J=8.4Hz, 2H) IR(KBr) 1609, 1520, 1481, 1365, 1338, 1294, 1270, 1233, 1178, 1153, 1118, 1078, 1015, 947cm⁻¹ I-632 ¹HNMR(CDCl₃) δ 1.45(s, 3H), 1.59(s, 3H), 1.66(s, 3H), 1.70(s, 3H), 2.97(s, 3H), 3.11(s, 3H), 3.64(s, 3H), 3.75(s, 3H), 4.28(d, J=8.4Hz, 2H), 4.32(d, J=8.4Hz, 2H), 5.18(s, 2H), 5.23(t, J=8.4Hz, 1H)), 5.29(t, J=8.4Hz, 1H), 6.70(s, 1H), 7.10(d, J=8.4Hz, 1H)7.30–7.51(m, 9H), 7.58(d, J=8.4Hz, 2H) I-633 ¹HNMR(CDCl₃) δ 1.58(s, 3H), 1.69(s, 3H), 2.97(s, 3H), 3.45(s, 3H), 3.75(s, 3H), 433(d, J=7.5Hz, 2H), 5.16(s, 2H), 5.24–5.33(m, 1H), 5.69(s, 1H), 5.87(s, 1H), 6.47(s, 1H), 6.95(d.d, J=8.4&2.1Hz, 1H), 7.03(d, J=8.4Hz, 1H), 7.09(.d, J=2.1Hz, 1H), 7.31–7.50(m, 7H), 7.65(d, J=8.4Hz, 2H) IR(KBr)3450, 1609, 1590, 1558, 1524, 1487, 1448, 1421, 1320, 1233, 1143, 1117, 1073, 1019cm⁻¹ I-634 ¹HNMR(CDCl₃) δ 1.57(s, 3H), 1.68(s, 3H), 2.66(s, 3H), 2.70(s, 3H), 3.13(s, 3H), 3.54(s, 3H), 3.78(s, 3H), 4.33(d, J=8.4Hz, 2H), 5.19(s, 2H), 5.26(t, J=8.4Hz), 6.86(s, 1H), 7.15(d, J=8.7Hz, 1H), 7.30–7.49(m, 9H), 7.63(d, J=8.4Hz, 2H) IR(KBr)1615, 1517, 1480, 1372, 1337, 1233, 1213, 1178, 1154, 1076, 1014cm⁻¹

TABLE 126 I-635 ¹HNMR(CDCl₃) δ 1.58(s, 3H), 1.69(s, 3H), 2.82(s, 3H), 2.97(s, 3H), 3.29(s, 3H), 3.53(s, 3H), 3.77(s, 3H), 4.33(d, J=7.2Hz, 2H), 5.27(t, J=7.2Hz, 1H), 6.25(s, 1H), 6.86(s, 1H), 7.17(d, J=9.0Hz, 1H)), 7.23–7.32(m, 2H), 7.41(d, J=8.7Hz, 2H), 7.63(d, J=8.7Hz, 2H) IR(KBr)3431, 1611, 1522, 1482, 1364, 1337, 1294, 1231, 1178, 1153, 1077, 1014cm⁻¹ I-636 ¹HNMR(CDCl₃) δ 1.76(s, 3H), 1.82(s, 3H), 3.09(s, 3H), 3.47(s, 3H), 3.75(s, 3H), 4.62(d, J=6.9Hz, 2H), 5.47–5.58(m, 1H), 5.71(s, 1H), 5.87(s, 1H), 6.45(s, 1H), 6.60(s, 1H), 6.89–7.01(m, 2H), 7.05(d, J=0.6Hz, 1H), 7.30(.d, J=8.7Hz, 2H), 7.65(d, J=8.7Hz, 2H) IR(KBr)3448, 3265, 1612, 1585, 1521, 1487, 1330, 1287, 1243, 1225, 1152, 1112, 1069, 971cm⁻¹ I-637 ¹HNM^(z)R(CDCl₃) δ 1.57(s, 3H), 1.69(s, 3H), 1.77(s, 3H), 1.81(s, 3H), 2.70(s, 3H), 2.97(s, 3H), 3.24(s, 3H), 3.54(s, 3H), 3.78(s, 3H), 4.32 (d, J=6.9Hz, 2H), 4.64(d, J=6.6Hz, 2H), 5.27(t, J=6.9Hz, 1H), 5.49(t, J=6.6Hz, 1H), 6.86(s, 1H), 7.09(d, J=8.4Hz, 1H), 7.32–7.44(m, 4H), 7.63(d, J=8.4Hz, 2H) IR(KBr)1609, 1520, 1481, 1365, 1339, 1292, 1270, 1236, 1178, 1153, 1118, 1078, 1015cm⁻¹ I-638 ¹HNMR(CDCl₃) δ 1.58(s, 3H), 1.69(s, 3H), 1.76(s, 3H), 1.82(s, 3H), 2.97(s, 3H), 3.45(s, 3H), 3.75(s, 3H), 4.32(d, J=7.8Hz, 2H), 4.63(.d, J=7.8Hz, 2H), 5.23–5.33(m, 1H), 5.48–5.57(m, 1H), 5.69(s, 1H), 5.85(s, 1H), 6.46(s, 1H), 6.89–7.02(m, 2H), 7.05(d, J=1.8Hz, 1H), 7.40(d, J=8.7Hz, 2H), 7.65(d, J=8.7Hz, 2H) IR(KBr)3450, 1609, 1588, 1557, 1525, 1487, 1445, 1327, 1248, 1148, 1114, 1072, 1015cm⁻¹ I-639 ¹HNMR(CDCl₃) δ 2.55(s, 3H), 2.67(s, 3H), 3.58(s, 3H), 3.79(s, 3H), 5.18(s, 2H), 5.71(s, 1H), 6.85(s, 1H), 6.91(d.d, J=8.4& 2.1Hz, 1H), 7.03(d, J=8.4Hz, 1H), 7.04(d, J=2.1Hz, 1H), 7.32–7.48(m, 6H), .7.85(.d.d, J=7.8&1.5Hz, 1H), 8.22(d, J=1.5Hz, 1H) IR(KBr)3457, 1739, 1529, 1481, 1407, 1376, 1346, 1279, 1243, 1177, 1128, 1071, 1012cm⁻¹ I-640 ¹HNMR(CDCl₃) δ 2.67(s, 3H), 2.68(s, 3H), 3.13(s, 3H), 3.58(s, 3H), 3.80(s, 3H), 5.19(s, 2H), 6.86(s, 1H), 7.15(d, J=8.7Hz, 1H), 7.31–7.49 (m, 8H), 7.83(d.d, J=8.1&1.8Hz, 1H), 8.21(d, J=1.8Hz, 1H) IR(KBr)3433, 1609, 1530, 1481, 1372, 1290, 1268, 1238, 1177, 1118, 1075, 1012cm⁻¹

TABLE 127 I-641 ¹HNMR(CDCl₃) δ 2.67(s, 3H), 3.50(s, 3H), 3.77(s, 3H), 5.16(s, 2H), 5.70(s, 1H), 5.83(s, 1H), 6.47(s, 1H), 6.94(d.d, J=8.7& 1.8Hz, 1H), 7.04(.d, J=8.7Hz, 1H), 7.07(d, J=1.8Hz, 1H), 7.34–7.48(m, 5H), 7.82(d.d, J=8.1&1.8Hz, 1H), 8.26(.d, J=1.8Hz, 1H) IR(KBr)3555, 3377, 1590, 1529, 1503, 1451, 1414, 1341, 1324, 1242, 1225, 1121cm⁻¹ I-642 ¹HNMR(CDCl₃) δ 2.29(s, 3H), 2.68(s, 3H), 3.12(s, 3H), 3.56(s, 3H), 3.76(s, 3H), 5.18(s, 2H), 6.85(s, 1H), 7.00–7.20(m, 4H), 7.31–7.49 (m, 7H) IR(KBr)3407, 1624, 1518, 1480, 1361, 1287, 1270, 1234, 1175, 1117, 1084, 1009cm⁻¹ I-643 ¹HNMR(CDCl₃) δ 2.40(s, 3H), 2.67(s, 3H), 3.09(s, 3H), 3.13(s, 3H), 3.59(s, 3H), 3.78(s, 3H), 5.19(s, 1H), 6.17(s, 1H), 6.85(s, 1H), 7.15 (d, J=8.4Hz, 1H), 7.30–7.49(m, 9H), 7.69(d, J=1.8Hz, 1H) IR(KBr)3433, 3304, 1608, 1519, 1481, 1365, 1326, 1294, 1269, 1237, 1177, 1156, 1114, 1079, 1015cm⁻¹ I-644 ¹HNMR(CDCl₃) δ 2.09(s, 3H), 2.39(s, 3H), 2.68(s, 3H), 3.13(s, 3H), 3.49(s, 3H), 3.76(s, 2H), 5.19(s, 2H), 6.30(s, 1H), 6.77(s, 1H), 7.12–7.24 (m, 3H), 7.31–7.49(m, 9H), 7.54(d, J=1.8Hz, 1H), 7.67(d, J=8.4Hz, 2H) IR(KBr)3434, 1608, 1519, 1481, 1366, 1293, 1269, 1237, 1164, 1114, 1081, 1016cm ⁻¹ I-645 ¹HNMR(CDCl₃) δ 2.09(s, 3H), 2.39(s, 3H), 3.43(s, 3H), 3.73(s, 3H), 5.16(s, 2H), 5.30(s, 1H), 5.68(s, 1H), 5.89(s, 1H), 6.32(s, 1H), 6.36(s, 1H), 6.95(d.d, J=8.7&2.1Hz, 1H), 7.03(d, J=8.7Hz, 1H), 7.08(d, J=2.1Hz, 1H), 7.14–7.28(m, 3H), 7.34–7.50(m, 5H), 7.61(.d, J=1.5Hz, 1H), 7.68(d, J=8.4Hz, 2H) IR(KBr)3465, 3270, 1612, 1587, 1558, 1519, 1487, 1454, 1384, 1244, 1160, 1123, 1105, 1091, 1070, 1009cm⁻¹ I-646 ¹HNMR(CDCl₃) δ 2.48(s, 3H), 2.63(s, 3H), 3.02(s, 3H), 3.13(s, 3H), 3.28(s, 2H), 3.54(s, 3H), 3.78(s, 3H), 5.19(s, 2H), 6.85(s, 1H), 7.15 (d, J=8.4Hz, 1H), 7.30–7.49(m, 9H), 7.59(s, 1H) IR(KBr)3433, 1606, 1519, 1481, 1364, 1341, 1292, 1272, 1233, 1178, 1148, 1118, 1082cm⁻¹ I-647 ¹HNMR(CDCl₃) δ 2.48(s, 3H), 3.02(s, 3H), 3.28(s, 3H), 3.46(s, 3H), 3.75(s, 3H), 5.16(s, 2H), 5.70(s, 1H), 5.84(s, 1H), 6.47(s, 1H), 6.94(d.d, J=8.4&2.1Hz, 1H), 7.03(.d, J=8.4Hz, 1H), 7.07(d, J=2.1Hz, 1H), 7.33–7.53(m, 7H), 7.62(d, J=1.8Hz, 1H) IR(KBr)3528, 3429, 1609, 1584, 1558, 1517, 1487, 1454, 1331, 1317, 1137, 1115, 1068, 1002cm⁻¹

TABLE 128 I-648 ¹HNMR(CDCl₃) δ 1.55(s, 3H), 2.45(s, 3H), 2.79(s, 3H), 3.02(s, 3H), 3.29(s, 3H), 3.52(s, 3H), 3.77(s, 3H), 4.12–4.31(m, 2H), 5.22–5.31 (m, 1H), 6.30(s, 11H), 6.84(s, 1H), 7.17(d, J=8.7Hz, 1H), 7.25–7.32(m, 2H), 7.39(d, J=8.4Hz, 1H), 7.45(d.d, J=8.4&1.8Hz, 1H), 7.53(d, J=1.8Hz, 1H) IR(KBr)3431, 1609, 1522, 1481, 1365, 1334, 1294, 1235, 1178, 1150, 1077, 1013cm⁻¹ I-649 ¹HNMR(CDCl₃) δ 1.54(s, 3H), 1.68(s, 3H), 1.76(s, 3H), 1.81(s, 3H), 2.45(s, 3H), 2.68(s, 3H), 3.02(s, 3H), 3.24(s, 3H), 3.52(s, 3H), 3.78(s, 3H), 4.10–4.34(m, 2H), 4.64(d, J=7.2Hz, 2H), 5.21–5.30(m, 1H), 5.45–5.53(m, 1H), 6.84(s, 1H), 7.08(d, J=8.4Hz, 1H), 7.31–7.48(m, 4H), 7.53(d, J=1.5Hz, 1H) IR(KBr)3432, 1606, 1518, 1481, 1362, 1340, 1292, 1276, 1236, 1177, 1153, 1116, 1076, 1010cm⁻¹ I-650 ¹HNMR(CDCl₃) δ 1.56(s, 3H), 1.68(s, 3H), 1.76(s, 3H), 1.82(s, 3H), 2.44(s, 3H), 3.02(s, 3H), 3.45(s, 3H), 3.75(s, 3H), 4.10–4.32(m, 2H), 4.62(d, J=7.2Hz, 2H), 5.22–5.32(m, 1H), 5.48–5.57(m, 1H), 5.60–5.80(brroad, 1H), 5.82(s, 1H), 6.46(s, 1H), 6.92(d.d, J=8.1 &1.8Hz, 1H), 6.97(d, J=8.1Hz, 1H), 7.04(d, J=1.8Hz, 1H), 7.38(d, J=8.1Hz, 1H), 7.47(d.d, J=8.1&1.8Hz, 1H), 7.57(d, J=1.8Hz, 1H) IR(KBr)3433, 1610, 1586, 1557, 1518, 1486, 1336, 1240, 1149, 1110, 1069cm⁻¹ I-651 ¹HNMR(CD₃OD) δ 3.33(s, 3H), 3.66(s, 3H), 5.18(s, 2H), 6.42(s, 1H), 1H), 6.75(dd, J=8.4&2.1Hz, 1H), 6.87(d, J=2.1Hz, 1H), 6.95(d, J=8.4Hz, 1H), 7.26–7.58(m, 8H), 7.81(d.d, J=7.8&1.2Hz, 1H) IR(KBr)3446, 1698, 1586, 1517, 1498, 1481, 1454, 1408, 1287, 1247, 1117, 1069, 1010cm⁻¹ I-652 ¹HNMR(CDCl₃) δ 1.76(s, 3H), 1.81(s, 3H), 2.76(s, 3H), 3.23(s, 3H), 3.43(s, 3H), 3.72(s, 3H), 3.76(s, 3H), 4.64(d, J=6.6Hz, 2H), 5.50(t, J=6.6Hz, 1H), 6.78(s, 1H), 7.08(d, J=8.7Hz, 1H), 7.33–7.51(m, 4H), 7.56–7.63(m, 1H), 7.96(d.d, J=7.5&1.2Hz, 1H) IR(KBr)1725, 1609, 1520, 1480, 1400, 1366, 1295, 1260, 1178, 1119, 1073, 1010cm⁻¹ I-653 ¹HNMR(CDCl₃) δ 2.38(s, 3H), 2.72(s, 3H), 3.12(s, 3H), 3.43(s, 3H), 3.73(s, 3H), 3.76(s, 3H), 5.14(s, 2H), 6.79(s, 1H), 7.13–7.24(m, 3H), 7.30–7.38(m, 3H), 7.41–7.51(m, 3H), 7.56–7.63(m, 1H), 795(d.d, J=7.5&1.2Hz, 1H) IR(KBr)1725, 1610, 1520, 1481, 1401, 1370, 1293, 1262, 1179, 1119, 1076, 1011cm⁻¹

TABLE 129 I-654 ¹HNMR(CDCl₃) δ 1.75(s, 3H), 1.81(s, 3H), 3.56(s, 3H), 3.72(s, 3H), 4.60(d, J=6.6Hz, 2H), 5.29(s, 1H), 5.46–5.56(m, 1H), 5.56–6.00(broad, 1H), 6.42(s, 1H), 6.94(s, 2H), 7.05(s, 1H), 7.43–7.52(m, 2H), 7.56–7.65(m, 1H), 7.99(.d, J=8.7Hz, 1H) IR(KBr)3433, 1697, 1585, 1517, 1481, 1454, 1410, 1287, 1244, 1117, 1068cm⁻¹ I-655 ¹HNMR(CDCl₃) δ 2.39(s, 3H), 3.37(s, 3H), 3.72(s, 3H), 5.10(s, 2H), 6.41(s, 1H), 6.94(dd, J=8.1&2.1Hz, 1H), 7.02(d, J=8.1Hz, 1H), 7.06 (d, J=2.1Hz, 1H), 7.23(d, J=7.8Hz, 2H), 7.35(.d, J=7.8Hz, 2H), 7.42–7.63(m, 3H), 7.96(d, J=7.8Hz, 1H) IR(KBr)3538, 3443, 1685, 1518, 1458, 1413, 1253, 1116, 1069, 1010cm⁻¹ I-656 m.p. 110–112° C. ¹HNMR(CDCl₃) δ 1.69(s, 3H), 1.74(s, 3H), 2.55(q, J=7.1Hz, 2H), 3.20(s, 3H), 3.21(s, 3H), 3.39(s, 3H), 3.70(s, 3H), 4.07(t, J=7.1Hz, 2H), 5.22(t, J=7.1Hz, 1H), 6.28(s, 1H), 7.09(d, J=8.4Hz, 1H), 7.32(dd, J=8.4, 2.0Hz, 1H), 7.36(d, J=8.9Hz, 2H), 7.37(d, J=2.0Hz, 1H), 7.69 (d, J=8.9Hz, 2H)IR(KBr)3477, 3402, 1607, 1518, 1481, 1365, 1151, 1111, 872, 813cm⁻¹ I-657 m.p. 159–162° C. ¹HNMR(DMSO-d₆) δ 1.64(s, 3H), 1.71(s, 3H), 2.45(q, J=6.7Hz, 2H), 3.27(s, 3H), 3.59(s, 3H), 3.96(t, J=6.7Hz, 2H), 4.22(s, 2H), 5.26(t, J=6.7Hz, 1H), 6.17(s, 1H), 6.60(dd, J=8.1, 2.0Hz, 1H), 6.67(d, J=2.0Hz, 1H), 6.83(d, J=8.7Hz, 2H), 6.95(d, J=8.1Hz, 1H), 7.42(d, J=8.7Hz, 2H), 8.89(s, 1H), 9.46(s, 1H) IR(KBr)3447, 3401, 3361, 1611, 1522, 1486, 1260, 1228, 1122, 1001, 814cm⁻¹ I-658 m.p. 146–147° C. ¹HNMR(CDCl₃) δ 1.14(t, J=7.2Hz, 3H), 1.76(d, J=0.9Hz, 3H), 1.81(d, J=0.3Hz, 3H), 2.70(s, 3H), 3.20(s, 3H), 3.23(s, 3H), 3.72(q, J=7.2Hz, 2H), 3.78(s, 3H), 4.64(d, J=6.6Hz, 2H), 5.49(m, 1H), 6.84(s, 1H), 7.09(d, J=8.4Hz, 1H), 7.31–7.41(m, 4H), 7.66–7.74(m, 2H) IR(CHCl₃)2930, 1608, 1517, 1479, 1369, 1148, 1116, 1082, 969, 872cm⁻¹ I-659 m.p. 174–175° C. ¹HNMR(CDCl₃) δ 1.14(t, J=6.9Hz, 3H), 2.37(s, 3H), 2.65(s, 3H), 3.12(s, 3H), 3.20(s, 3H), 3.72(q, J=6.9Hz, 2H), 3.77(s, 3H), 5.14(s, 2H), 6.84(s, 1H), 7.15(d, J=8.4Hz, 1H), 7.18–7.42(m, 6H), 7.66–7.73(m, 2H) IR(CHCl₃)1517, 1479, 1369, 1268, 1148, 1117, 1082, 969, 872cm⁻¹

TABLE 130 I-660 m.p. 147.5–148° C. ¹HNMR(CDCl₃) δ 1.14(t, J=7.2Hz, 3H), 1.68(s, 3H), 1.74(d, J=0.9Hz, 3H), 2.50–2.59(m, 2H), 2.72(s, 3H), 3.20(s, 3H), 3.22(s, 3H), 3.72 (q, J=7.2Hz, 2H), 3.77(s, 3H), 4.07(d, J=6.9Hz, 2H), 5.21(m, 1H), 6.84(s, 1H), 7.07(d, J=8.7Hz, 1H), 7.31–7.42(m, 4H), 7.66–7.74(m, 2H) IR(CHCl₃)2930, 1607, 1517, 1480, 1369, 1148, 1118, 1082, 1025, 969, 872cm⁻¹ I-661 m.p. 154–157° C. ¹HNMR(CDCl₃) δ 1.15(t, J=7.2Hz, 3H), 1.76(s, 3H), 1.82(s, 3H), 3.60(q, J=7.2Hz, 2H), 3.75(s, 3H), 4.61(d, J=6.9Hz, 2H), 4.93(s, 1H), 5.53(m, 1H), 5.69(s, 1H), 5.96(s, 1H), 6.45(s, 1H), 6.80–6.98(m, 4H), 7.07(m, 1H), 7.51–7.58(m, 2H) IR(CHCl₃)3592, 3528, 2976, 2934, 1611, 1521, 1488, 1460, 1384, 1286, 1243, 1169, 1112, 1068, 994, 885, 824cm⁻¹ I-662 m.p. 130.5–133° C. ¹HNMR(CDCl₃) δ 1.15(t, J=7.2Hz, 3H), 2.39(s, 3H), 3.59(q, J=7.2Hz, 2H), 3.74(s, 3H), 4.83(s, 1H), 5.10(s, 2H), 5.66(s, 1H), 5.97(s, 1H), 6.44(s, 1H), 6.87–6.94(m, 2H), 6.96(dd, J=1.8, 8.4Hz, 1H), 7.02(d, J=8.4Hz, 1H), 7.09(d, J=1.8Hz, 1H), 7.19–7.26(m, 2H), 7.30–7.38( m, 2H), 7.51–7.58(m, 2H) IR(CHCl₃)3524, 1612, 1521, 1488, 1460, 1383, 1286, 1246, 1113, 1069, 1027, 907, 873cm⁻¹ I-663 amorphous powder ¹HNMR(CDCl₃) δ 1.15(t, J=7.2Hz, 3H), 1.68(d, J=0.6Hz, 3H), 1.74(d, J=0.9Hz, 3H), 2.48–2.56(m, 2H), 3.60(q, J=7.2Hz, 2H), 3.74(s, 3H), 4.06(d, J=6.9Hz, 2H), 4.95(s, 1H), 5.22(m, 1H), 5.68(s, 1H), 5.96(s, 1H), 6.44(s, 1H), 6.88–6.99(m, 4H), 7.06(d, J=1.2Hz, 1H), 7.51–7.58 (m, 2H) IR(CHCl₃)3528, 2972, 1611, 1521, 1488, 1384, 1286, 1246, 1112, 1068, 1024, 883, 824cm⁻¹ I-664 m.p. 113–116° C. ¹HNMR(CDCl₃) δ 2.55(s, 6H), 3.45(s, 3H), 3.74(s, 3H), 5.31(s, 2H), 6.44(s, 1H), 6.92(d, J=8.7Hz, 2H), 6.94(dd, J=8.4, 2.1Hz, 1H), 7.10 (s, 1H), 7.10(d, J=2.1Hz, 1H), 7.20(d, J=8.7Hz, 1H), 7.52(d, J=8.7Hz, 2H) IR(Nujol)3491, 3443, 3304, 3155, 1662, 1608, 1523, 1492, 1464, 1251, 1215, 1111, 1067, 811, 782cm⁻¹

TABLE 131 I-665 m.p.>260° C. ¹HNMR(CD₃OD) δ 3.39(s, 3H), 3.68(s, 3H), 5.40(s, 2H), 6.44(s, 1H), 6.83(dd, J=8.4, 2.1Hz, 1H), 6.85(d, J=8.7, 2H), 6.90(d, J=2.1Hz, 1H), 7.11 (d, J=8.4Hz, 1H), 7.46(d, J=8.7Hz, 2H) IR(Nujol)3350, 2668, 1611, 1595, 1530, 1488, 1458, 1402, 1253, 1213, 1116, 1073, 1016, 837, 817, 781cm⁻¹ I-666 foam ¹HNMR(CDCl₃) δ 2.34(s, 3H), 2.44(s, 3H), 2.83(s, 3H), 3.12(s, 3H), 3.22(s, 3H), 3.55(s, 3H), 3.78(s, 3H), 4.92(s, 2H), 6.85(s, 1H), 7.17(d, J=8.4Hz, 1H), 7.37–7.42(m, 2H), 7.39(d, J=8.7Hz, 2H), 7.68(d, J=8.7Hz, 2H) IR(Nujol)1638, 1608, 1519, 1480, 1459, 1177, 1151, 1079, 971, 876, 844, 798cm⁻¹ I-667 foam ¹HNMR(CDCl₃) δ 2.07(s, 3H), 2.53(s, 3H), 2.96(s, 3H), 3.23(s, 3H), 3.27(s, 3H), 3.54(s, 3H), 3.78(s, 3H), 4.86(s, 2H), 6.86(s, 1H), 7.11(d, J=9.0Hz, 1H), 7.33–7.41(m, 2H), 7.39(d, J=8.7Hz, 2H), 7.67(d, J=8.7Hz, 2H) IR(Nujol)1724, 1688, 1610, 1520, 1481, 1464, 1234, 1177, 1151, 1123, 1081, 876, 798cm⁻¹ I-668 m.p. 221–223° C. ¹HNMR(DMSO-d₆) δ 3.30(s, 3H), 3.64(s, 3H), 5.16(s, 2H), 6.39(s, 1H), 6.66(dd, J=8.4, 2.1Hz, 1H), 6.77(d, J=2.1Hz, 1H), 6.84(d, J=8.7Hz, 2H), 7.00(d, J=8.4Hz, 1H), 7.34(s, 1H), 7.44(d, J=8.7Hz, 2H), 8.43(s, 1H) IR(Nujol)3535, 3411, 1611, 1582, 1521, 1488, 1463, 1244, 1194, 1135, 1119, 1074, 1014, 930, 826, 809cm⁻¹ I-669 foam ¹HNMR(CDCl₃) δ 2.79(s, 3H), 3.17(s, 3H), 3.22(s, 3H), 3.55(s, 3H), 3.78(s, 3H), 5.21(s, 2H), 6.85(s, 1H), 7.19(d, J=8.4Hz, 1H), 7.23(s, 1H), 7.38(dd, J=8.7, 2.1Hz, 1H), 7.39(d, J=8.7Hz, 2H), 7.42(d, J=2.1Hz, 1H), 7.68(d, J=8.7Hz, 2H), 7.94(s, 1H) IR(Nujol)1608, 1519, 1480, 1463, 1177, 1151, 1119, 1079, 971, 876, 798cm⁻¹

TABLE 132 I-670 m.p. 198–201° C. ¹HNMR(DMSO-d₆) δ 2.88(s, 3H), 3.39(s, 3H), 3.45(s, 3H), 3.52(s, 3H), 3.78(s, 3H), 4.58(s, 2H), 5.60(s, 1H), 7.07(s, 1H), 7.29(dd, J=9.0, 1.8Hz, 1H), 7.30(d, J=1.8,Hz, 1H), 7.37(d, J=9.0Hz, 1H), 7.48(d, J=8.7Hz, 2H), 7.74(d, J=8.7Hz, 2H), 9.39(s, 1H) IR(Nujol)3576, 3500, 3405, 3391, 1668, 1607, 1590, 1520, 1480, 1462, 1175, 1156, 1081, 1014, 880, 836, 826, 801cm⁻¹ I-671 foam ¹HNMR(CDCl₃) δ 2.61(s, 3H), 2.73(s, 3H), 3.21(s, 3H), 3.23(s, 3H), 3.55(s, 3H), 3.78(s, 3H), 5.32(s, 2H), 6.84(s, 1H), 7.17(d, J=8.4Hz, 1H), 7.36(dd, J=8.4, 2.1Hz, 1H), 7.38(d, J=8.7,Hz, 2H), 7.43(d, J=2.1Hz, 1H), 7.68(d, J=8.7Hz, 2H), 8.46(s, 1H), 8.75(s, 1H) IR(Nujol)1608, 1519, 1481, 1463, 1177, 1151, 1080, 971, 876, 798cm⁻¹ I-672 foam ¹HNMR(CDCl₃) δ 2.75(s, 3H), 3.21(s, 3H), 3.25(s, 3H), 3.55(s, 3H), 3.78(s, 3H), 5.37(s, 2H), 6.84(s, 1H), 7.17(d, J=8.4Hz, 1H), 7.36(dd, J=8.4, 2.1Hz, 1H), 7.38(d, J=8.7,Hz, 2H), 7.43(d, J=2.1Hz, 1H), 7.68(d, J=8.7Hz, 2H), 8.59(s, 1H), 8.92(s, 1H) IR(Nujol)1608, 1519, 1480, 1463, 1177, 1151, 1080, 971, 876, 798cm⁻¹ I-673 foam ¹HNMR(CDCl₃) δ 2.70(s, 3H), 3.15(s, 3H), 3.21(s, 3H), 3.55(s, 3H), 3.78(s, 3H), 5.14(s, 2H), 6.77(m, 2H), 6.84(s, 1H), 7.19(m, 2H), 7.26(d, J=8.4Hz, 1H), 7.37(d, J=2.1Hz, 1H), 7.38(dd, J=2.1, 8.4Hz, 1H), 7.68(d, J=8.4Hz, 2H) I-674 m.p. 153–156° C. ¹HNMR(CDCl₃) δ 2.18(s, 3H), 2.81(s, 3H), 3.18(s, 3H), 3.22(s, 3H), 3.55(s, 3H), 3.79(s, 3H), 5.14(s, 2H), 6.86(s, 1H), 7.18(dd, J=8.1, 8.1Hz, 1H), 7.24(d, J=8.1Hz, 1H), 7.26(d, J=8.4Hz, 1H), 7.36(d, J=1.8Hz, 1H), 7.38(d, J=8.4Hz, 2H), 7.39(dd, J=1.8, 8.4Hz, 1H), 7.43(dd, J=8.1, 8.1Hz, 1H), 7.67(d, J=8.4Hz, 2H), 7.90(d, J=8.1Hz, 1H) IR(KBr)3384, 1689, 1519, 1481, 1364, 1177, 1151, 1079, 970, 874, 798cm⁻¹

TABLE 133 1-675 foam ¹HNMR(CDCl₃) δ 2.76(s, 3H), 3.16(s, 3H), 3.22(s, 3H), 3.23(s, 3H), 3.55(s, 3H), 3.78(s, 3H), 5.23(s, 2H), 6.85(s, 1H), 7.23(dd, J=7.5, 7.5Hz, 1H), 7.37(s, 2H), 7.38(d, J=8.4Hz, 2H), 7.43(m, 3H), 7.54(d, J=7.5Hz, 1H), 7.68(d, J=8.4Hz, 2H) IR(KBr)3435, 1609, 1519, 1481, 1364, 1177, 1152, 1079, 972, 876, 798 cm⁻¹ 1-676 m.p.163–165° C. ¹HNMR(CDCl₃) δ 2.78(s, 3H), 3.03(s, 3H), 3.21(s, 3H), 3.45(s, 6H), 3.55(s, 3H), 3.79(s, 3H), 5.31(s, 2H), 6.84(s, 1H), 7.22(d, J=8.4Hz, 1H), 7.37(dd, J=2.4, 8.4Hz, 1H), 7.38(d, J=8.4Hz, 2H), 7.42(m, 2H), 7.53(m, 2H), 7.67(d, J=8.4Hz, 2H), 7.68(m, 1H) IR(KBr)1609, 1519, 1481, 1365, 1176, 1161, 1080, 973, 875, 799 cm⁻¹ 1-677 m.p. 153–156° C. ¹HNMR(CDCl₃) δ 2.69(s, 3H), 2.98(s, 3H), 3.17(s, 3H), 3.21(s, 3H), 3.33(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 5.44(s, 2H), 6.84(s, 1H), 7.21(d, J=8.7Hz, 1H), 7.31–7.46(m, 5H), 7.38(d, J=8.4Hz, 2H), 7.68(d, J=8.4Hz, 2H), 7.72(m, 1H) IR(KBr)1610, 1519, 1481, 1365, 1177, 1149, 1079, 963, 876, 799 cm⁻¹ 1-678 foam ¹HNMR(CDCl₃) δ 2.60(s, 3H), 2.75(s, 6H), 3.17(s, 3H), 3.21(s, 3H), 3.55(s, 3H), 3.78(s, 3H), 5.31(s, 2H), 6.83(s, 1H), 7.08(dd, J=7.5, 7.5Hz, 1H), 7.16(d, J=8.4Hz, 1H), 7.17(d, J=7.5Hz, 1H), 7.30(dd, J=2.1, 8.4Hz, 1H), 7.32(dd, J=7.5, 7.5Hz, 1H), 7.37(d, J=8.4Hz, 2H), 7.38(d, J=2.1Hz, 1H), 7.52(d, J=7.5Hz, 1H), 7.68(d, J=8.4Hz, 2H) IR(KBr)1609, 1519, 1480, 1365, 1235, 1177, 1151, 1079, 970, 874, 797 cm¹ 1-679 m.p. 95–97° C. ¹HNMR(CDCl₃) δ 1.76(s, 3H), 1.80(s, 3H), 3.03(s, 3H), 3.21(s, 3H), 3.56(s, 3H), 3.75(s, 3H), 4.63(d, J=6.9Hz, 2H), 4.93(s, 2H), 5.51(m, 1H), 6.66(s, 1H), 7.05(d, J=8.4Hz, 1H), 7.09–7.17(m, 2H), 7.37(dd, J=2.4, 8.4Hz, 1H), 7.44(d, J=2.4Hz, 1H), 7.51–7.58(m, 2H) IR(KBr)3435, 2936, 1605, 1519, 1475, 1382, 1365, 1232, 1161, 1109, 1080 cm⁻¹

TABLE 134 I-680 m.p. 142–144° C. ¹HNMR(CDCl₃) δ 1.76(s, 3H), 1.81(s, 3H), 3.07(s, 3H), 3.57(s, 3H), 3.74(s, 3H), 4.61(d, J=6.6Hz, 2H), 4.90(s, 2H), 5.51(m, 1H), 5.65(s, 1H), 6.66(s, 1H), 6.92(m, 2H), 7.03(m, 1H), 7.09–7.17(m, 2H), 7.52–7.58(m, 2H) IR(KBr)3455, 2964, 2932, 1606, 1583, 1519, 1479, 1387, 1283, 1227, 1153, 1115, 1080, 1094, 1004cm⁻¹ I-681 m.p. 158–160° C. ¹HNMR(CDCl₃) δ 1.76(s, 3H), 1.81(s, 3H), 3.20(s, 3H), 3.42(s, 3H), 3.76(s, 3H), 4.63(d, J=6.6Hz, 2H), 5.51(m, 1H), 6.04(s, 1H), 6.43(s, 1H), 7.07(d, J=8.4Hz, 1H), 7.11–7.19(m, 2H), 7.42(dd, J=2.1, 8.4Hz, 1H), 7.50(d, J=2.1Hz, 1H), 7.58–7.65(m, 2H) IR(KBr)3505, 3440, 1613, 1522, 1489, 1386, 1352, 1292, 1227, 1109, 1013cm⁻¹ I-682 m.p. 175–178° C. ¹HNMR(CDCl₃) δ 1.63(s, 3H), 1.92–2.13(m, 4H), 3.22(s, 3H), 3.42(s, 3H), 3.76(s, 3H), 4.13(t, J=6.3Hz, 2H), 6.04(s, 1H), 6.44(s, 1H), 7.06 (d, J=8.4Hz, 1H), 7.11–7.19(m, 2H), 7.43(dd, J=2.1, 8.4Hz, 1H), 7.49(d, J=2.1Hz, 1H), 7.57–7.65(m, 2H) IR(KBr)3467, 2973, 2943, 1613, 1523, 1489, 1359, 1232, 1113, 1072cm⁻¹ I-683 powder ¹HNMR(CDCl₃) δ 1.69(s, 3H), 1.75(s, 3H), 2.48–2.57(m, 2H), 3.08(s, 3H), 3.57(s, 3H), 3.74(s, 3H), 4.06(t, J=6.9Hz, 2H), 4.90(s, 2H), 5.22 (m, 1H), 5.64(s, 1H), 6.66(s, 1H), 6.91(m, 2H), 7.03(m, 1H), 7.08–7.17(m, 2H), 7.52–7.59(m, 2H) IR(KBr)3432, 2930, 1604, 1583, 1518, 1475, 1382, 1280, 1249, 1222, 1160, 1111, 1082cm⁻¹ I-684 m.p. 151–153° C. ¹HNMR(CDCl₃) δ 1.69(s, 3H), 1.73(s, 3H), 2.50–2.59(m, 2H), 3.19(s, 3H), 3.42(s, 3H), 3.76(s, 3H), 4.06(t, J=6.9Hz, 2H), 5.21(m, 1H), 6.02 (s, 1H), 6.43(s, 1H), 7.05(d, J=8.4Hz, 1H), 7.11–7.19(m, 2H), 7.42(dd, J=2.4, 8.4Hz, 1H), 7.50(d, J=2.4Hz, 1H), 7.57–7.65(m, 2H) IR(KBr)3457, 2937, 1613, 1523, 1489, 1465, 1390, 1361, 1295, 1234, 1185, 1110, 1072, 1013cm⁻¹

TABLE 135 I-685 m.p. 156–158° C. ¹HNMR(CDCl₃) δ 1.76(s, 3H), 1.81(s, 3H), 3.21(s, 3H), 3.42(s, 3H), 3.76(s, 3H), 4.54(d, J=6.9Hz, 2H), 5.52(t, J=6.9Hz, 1H), 6.94(s, 1H), 6.94(d, J=8.7Hz, 2H), 7.29(d, J=8.7Hz, 2H), 7.37(d, J=8.7Hz, 2H), 7.71(d, J=8.7Hz, 2H) IR(KBr)1734, 1517, 1464, 1360, 1237, 1150, 1061, 988, 862cm⁻¹ I-686 m.p. 189–191° C. ¹HNMR(CDCl₃) δ 3.21(s, 3H), 3.21(s, 3H), 3.42(s, 3H), 3.61(s, 3H), 3.76(s, 3H), 5.09(s, 2H), 6.94(s, 1H), 7.10(d, J=8.4Hz, 2H), 7.28–7.48 (m, 9H), 7.71(d, J=8.4Hz, 2H) IR(KBr)1727, 1518, 1469, 1365, 1239, 1152, 1061, 865cm⁻¹ I-687 m.p. 112–113° C. ¹HNMR(CDCl₃) δ 1.68(s, 3H), 1.74(s, 3H), 2.50(q, J=7.2Hz, 2H), 3.21(s, 3H), 3.42(s, 3H), 3.62(s, 3H), 3.76(s, 3H), 3.96(t, J=7.2Hz, 2H), 5.23 (t, J=7.2Hz, 1H), 6.92(d, J=8.8Hz, 2H), 6.93(s, 1H), 7.28(d, J=8.8Hz, 2H), 7.37(d, J=8.8Hz, 2H), 7.71(d, J=8.8Hz, 2H) IR(KBr)1735, 1519, 1469, 1361, 1246, 1153, 1059, 877, 861, 847, 791cm⁻¹ I-688 m.p. 191–193° C. ¹HNMR(DMSO-d₆) δ 1.73(s, 3H), 1.76(s, 3H), 3.31(s, 3H), 3.71(s, 3H), 4.54(d, J=6.9Hz, 2H), 5.46(t, J=6.9Hz, 1H),(s, 1H), 6.87(d, J=8.7Hz, 2H), 6.91(s, 1H), 6.92(d, J=8.7Hz, 2H), 7.19(d, J=8.7Hz, 2H), 7.48(d, J=8.7Hz, 2H), 9.59(s, 1H), 12.8(brs, 1H) IR(KBr)3462, 1695, 1609, 1520, 1472, 1231, 1177, 1062, 1001, 837cm⁻¹ I-689 m.p. 229–232° C. ¹HNMR(DMSO-d₆) δ 3.31(s, 3H), 3.71(s, 3H), 5.12(s, 2H), 6.87(d, J=8.8Hz, 2H), 6.98(s, 1H), 7.01(d, J=8.8Hz, 2H), 7.21(d, J=8.8Hz, 2H), 7.34–7.50(m, 7H), 9.58(s, 1H), 12.8(brs, 1H) IR(KBr)3424, 3238, 1685, 1610, 1521, 1464, 1379, 1235, 1180, 1057, 1001, 826cm⁻¹

TABLE 136 I-690 m.p. 171–172° C. ¹HNMR(DMSO-d₆) δ 1.64(s, 3H), 1.70(s, 3H), 2.43(q, J=6.9Hz, 2H), 3.31(s, 3H), 3.70(s, 3H), 3.96(t, J=6.9Hz, 2H), 5.23(t, J=6.9Hz, 1H), 6.87 (d, J=8.8Hz, 2H), 6.91(d, J=8.8Hz, 2H), 6.98(s, 1H), 7.19(d, J=8.8Hz, 2H), 7.48(d, J=8.8Hz, 2H), 9.58(s, 1H), 12.8(brs, 1H) IR(KBr)3402, 3266, 1689, 1612, 1521, 1470, 1376, 1241, 1181, 1063, 1001, 829cm⁻¹ I-691 mp 191–193° C. ¹HNMR(CDCl₃) δ 2.55(s, 3H), 3.52(s, 3H), 3.77(s, 3H), 5.17(s, 2H), 5.70(s, 1H), 6.83(s, 1H), 6.91(dd, J=1.8, 8.1Hz, 1H), 7.00–7.05 (m, 2H), 7.10–7.19(m, 2H), 7.34–7.45(m, 5H), 7.57–7.65(m, 2H) IR(KBr)3030, 2934, 1606, 1523, 1487, 1391, 1358, 1290, 1228, 1077, 1019, 947, 831, 815, 803cm⁻¹ I-692 mp 172–173° C. ¹HNMR(CDCl₃) δ 2.47(s, 3H), 3.52(s, 3H), 3.53(s, 3H), 3.77(s, 3H), 5.21(s, 2H), 5.25(s, 2H), 6.82(s, 1H), 7.01–7.03(m, 2H), 7.11–7.18 (m, 2H), 7.22–7.41(m, 6H), 7.57–7.63(m, 2H) IR(KBr)3010, 2931, 1602, 1519, 1484, 1385, 1369, 1232, 1174, 1085, 847, 806, 729, 527cm⁻¹ I-693 mp 129–132° C. ¹HNMR(CDCl₃) δ 3.44(s, 3H), 3.53(s, 3H), 3.75(s, 3H), 5.20(s, 2H), 5.26(s, 2H), 5.91(s, 1H), 6.44(s, 1H), 7.01(d, J=8.1Hz, 1H), 7.08(dd, J=1.8Hz, 8.1Hz, 1H), 7.11–7.18(m, 2H), 7.28–7.50(m, 6H), 7.57–7.64(m, 2H) IR(KBr)2996, 2952, 2932, 2895, 1609, 1522, 1488, 1229, 1120, 1075, 999, 911, 815, 724, 582cm⁻¹ I-694 mp 124–126° C. ¹HNMR(CDCl₃) δ 1.76(d, J=0.6Hz, 3H), 1.80(d, J=0.9Hz, 3H), 2.69(2H, s), 3.54(s, 3H), 3.57(s, 3H), 3.76(s, 3H), 4.64(d, J=6.6Hz, 2H), 5.26(s, 3H), 5.54(m, 1H), 6.86(s, 1H), 6.98(d, J=8.7Hz, 1H), 7.13–7.25(m, 3H), 7.38–7.43(m, 3H) IR(CHCl₃)2935, 2855, 1675, 1603, 1520, 1481, 1387, 1370, 1247, 1178, 1158, 1134, 1081, 1003, 961, 839, 814cm⁻¹

TABLE 137 I-695 mp 141–142° C. ¹HNMR(CDCl₃) δ 2.34(s, 3H), 2.48(s, 3H), 5.16(s, 2H), 5.70(s, 1H), 6.82(dd, J=8.4, 2.1Hz, 1H), 6.97–7.00(m, 2H), 7.07–7.13 (m, 4H), 7.32–7.46(m, 7H) IR(CHCl₃)3543, 3023, 2871, 1604, 1587, 1520, 1489, 1469, 1383, 1267, 1243, 1158, 1126, 1014, 957, 877, 839cm⁻¹ I-696 mp 178–180° C. ¹HNMR(CDCl₃) δ 2.75(s, 3H), 3.18(s, 3H), 3.55(s, 3H), 3.76(s, 3H), 5.18(s, 2H), 5.72(s, 1H), 6.87(s, 1H), 7.00(d, J=8.7Hz, 1H), 7.15(dd, J=8.7, 2.1Hz, 1H), 7.24–7.28(m, 2H), 7.36–7.50(m, 8H) IR(CHCl₃)3543, 3027, 2939, 1519, 1481, 1371, 1330, 1254, 1204, 1177, 1150, 1082, 1005, 969, 873cm⁻¹ I-697 mp 129–130° C. ¹HNMR(CDCl₃) δ 2.24(s, 3H), 2.29(s, 3H), 3.12(s, 3H), 5.18(s, 2H), 7.08–7.14(m, 5H), 7.25–7.50(m, 9H) IR(CHCl₃)2925, 2871, 1604, 1520, 1490, 1455, 1369, 1291, 1262, 1169, 1111, 1007, 972, 957, 882, 840, 816cm⁻¹ I-698 mp 124–125° C. ¹HNMR(CDCl₃) δ 1.77(s, 3H), 1.81–1.82(d, J=0.9Hz, 3H), 2.24(s, 3H), 2.28(s, 3H), 3.22(s, 3H), 4.63(d, J=6.6Hz, 2H), 5.52(m, 1H), 7.04–7.14(m, 5H), 7.24–7.34(m, 4H) IR(KBr)2978, 2924, 2868, 1893, 1771, 1604, 1520, 1489, 1368, 1290, 1261, 1169, 1109, 1046, 973, 957, 882, 740, 816cm⁻¹ I-699 oil ¹HNMR(CDCl₃) δ 1.69(s, 3H), 1.74–1.75(d, J=0.9Hz, 3H), 2.24(s, 3H), 2.28(s, 3H), 2.55(m, 2H), 3.21(s, 3H), 4.05–4.10 (t, J=6.9Hz, 2H), 5.22(m, 1H), 7.03–7.14(m, 5H), 7.24–7.34(m, 4H) IR(CHCl₃)2970, 2926, 2875, 1605, 1520, 1490, 1470, 1368, 1292, 1277, 1169, 1110, 1016, 973, 958, 878, 840, 819cm⁻¹ I-700 mp 121–123° C. ¹HNMR(CDCl₃) δ 2.24(s, 3H), 2.83(s, 3H), 2.98(s, 3H), 3.11(s, 3H), 5.13(s, 2H), 7.08–7.14(m, 4H), 7.21–7.37(m, 9H) IR(CHCl₃)2925, 1605, 1520, 1489, 1369, 1262, 1169, 1014, 1003, 972, 957, 882, 840, 816cm⁻¹

TABLE 138 I-701 mp 215–217° C. ¹H NMR(CDCl₃) δ 2.73(s, 3H), 3.13(s, 3H), 3.18(s, 3H), 3.57(s, 3H), 3.78(s, 3H), 5.20(s, 2H), 6.86(s, 1H), 7.16(d, J=8.7Hz, 1H), 7.35–7.50(m, 9H), 7.56(dd, J=8.4, 2.4Hz, 1H), 7.62(d, J=2.4Hz, 1H) IR(CHCl₃) 2939, 1613, 1519, 1480, 1371, 1294, 1254, 1176, 1150, 1119, 1083, 1003, 970, 871, 849, 816cm⁻¹ I-702 mp 71–73° C. ¹H NMR(CDCl₃) δ 1.77(s, 3H), 1.83(s, 3H), 2.24(s, 3H), 2.29(s, 3H), 4.61–4.64(d, J=6.9Hz, 2H), 5.54(m, 1H), 5.71(s, 1H), 6.80–6.84(dd, J=8.4, 2.1Hz, 1H), 6.92(d, J=8.4Hz, 1H), 7.07–7.13(m, 4H), 7.30–7.35(m, 2H) IR(KBr) 3537, 2977, 2924, 2868, 1604, 1585, 1520, 1489, 1450, 1386, 1292, 1267, 1242, 1158, 1125, 996, 957, 839cm⁻¹ I-703 oil ¹H NMR(CDCl₃) δ 1.69(s, 3H), 1.75–1.76(d, J=0.9Hz, 3H), 2.24(s, 3H), 2.28(s, 3H), 2.50–2.57(td, J=6.9, 6.3Hz, 2H), 4.05–4.10(t, J=6.3Hz, 2H), 5.24(m, 1H), 5.70(s, 1H), 6.81(dd, J=8.4, 1.8Hz, 1H), 6.90(d, J=8.4Hz, 1H), 6.96(d, J=1.8Hz, 1H), 7.06–7.13(m, 4H), 7.26–7.34(m, 2H) IR(CHCl₃) 3540, 2972, 2925, 2877, 1604, 1585, 1520, 1490, 1387, 1293, 1267, 1245, 1158, 1127, 1016, 957, 839cm⁻¹ I-704 mp 113–115° C. ¹H NMR(CDCl₃) δ 2.24(s, 3H), 2.28(s, 3H), 2.39(s, 3H), 5.11(s, 2H), 5.69(s, 1H), 6.82(dd, J=8.4, 2.4Hz, 1H), 6.97–7.00 (m, 2H), 7.07–7.13(m, 3H), 7.22–7.36(m, 7H) IR(CHCl₃) 3541, 2925, 2871, 1604, 1586, 1520, 1490, 1469, 1380, 1324, 1308, 1292, 1267, 1243, 1201, 1158, 1126, 1013, 957, 876, 839cm⁻¹

TABLE 139 I-705 foam ¹H NMR(CDCl₃) δ 3.20(s, 3H), 3.27(s, 3H), 3.43(s, 3H), 3.73(s, 3H), 4.37(br d, J=5.7Hz, 2H), 4.58(s, 2H), 5.16(s, 2H), 5.68(s, 1H), 6.82(dd, J=8.2, 1.7Hz, 1H), 6.88(s, 1H), 6.97(d, J=1.7Hz, 1H), 6.98(d, J=8.2Hz, 1H), 7.35–7.47(m, 7H), 7.71(d, J=8.7Hz, 2H) IR(KBr) 3464, 1515, 1474, 1369, 1230, 1199, 1176, 1149, 1039, 873cm⁻¹ I-706 foam ¹H NMR(CDCl₃) δ 2.42(br s, 1H), 3.12(s, 3H), 3.22(s, 3H), 3.45(s, 3H), 3.74(s, 3H), 4.49(br s, 1H), 5.18(s, 2H), 6.85(s, 1H), 7.15(d, J=8.6Hz, 1H), 7.27(dd, J=8.6, 2.0Hz, 1H), 7.35–7.50(m, 8H), 7.71(d, J=8.6Hz, 2H) IR(KBr) 3583, 3435, 1519, 1467, 1412, 1229, 1180, 1150, 1022, 875, 849, 798, 742, 706cm⁻¹ I-707 mp 120–121° C. ¹H NMR(CDCl₃) δ 3.45(s, 3H), 3.45(s, 3H), 3.75(s, 3H), 4.66(s, 2H), 4.77(s, 2H), 5.15(s, 2H), 5.67(s, 1H), 5.91(s, 1H), 6.47(s, 1H), 6.96(dd, J=8.4, 1.9Hz, 1H), 7.03(d, J=8.4Hz, 1H), 7.09(d, J=1.9Hz, 1H), 7.37–7.47(m, 7H), 7.64(d, J=8.4Hz, 2H) IR(KBr) 3504, 3461, 1522, 1485, 1466, 1384, 1466, 1384, 1283, 1245, 1197, 1110, 1042, 925, 812, 749cm⁻¹ I-708 mp 156–158° C. ¹H NMR(CDCl₃) δ 3.11(s, 3H), 3.21(s, 3H), 3.28(s, 3H), 3.42(s, 3H), 3.73(s, 3H), 4.38(s, 2H), 4.58(s, 2H), 5.18(s, 2H), 6.88(s, 1H), 7.12(d, J=8.7Hz, 1H), 7.27(dd, J=8.7, 2.1Hz, 1H), 7.35–7.50(m, 8H), 7.70(d, J=8.7Hz, 2H) IR(KBr) 1514, 1469, 1360, 1177, 1149, 1099, 1042, 870cm⁻¹ I-709 mp 188–190° C. ¹H NMR(CDCl₃) δ 1.70(t, J=5.7Hz, 1H), 3.45(s, 3H), 3.75(s, 3H), 4.77(d, J=5.7Hz, 2H), 5.16(s, 2H), 5.68(s, 1H), 5.91(s, 1H), 6.47(s, 1H), 6.96(dd, J=8.5, 1.7Hz, 1H), 7.03(d, J=8.5Hz, 1H), 7.09(d, J=1.7Hz, 1H), 7.37–7.48(m, 7H), 7.65(d, J=8.4Hz, 2H) IR(KBr) 3547, 3492, 3451, 1521, 1487, 1385, 1288, 1249, 1209, 1108, 1011, 746, 702cm⁻¹

TABLE 140 I-710 mp 178–180° C. ¹H NMR(CDCl₃) δ 2.43(br s, 1H), 3.44(s, 3H), 3.72(s, 3H), 4.52(m, 2H), 4.93(s, 1H), 5.15(s, 2H), 5.70(s, 1H), 6.79(dd, J=8.1, 2.1Hz, 1H), 6.84(s, 1H), 6.92(d, J=8.7Hz, 2H), 6.93(d, J=2.1Hz, 1H), 7.00(d, J=8.7Hz, 1H), 7.38–7.48(m, 5H), 7.54(d, J=9.0Hz, 2H) IR(KBr) 3447, 3214, 1609, 1518, 1477, 1459, 1391, 1260, 1221, 1008, 984, 833, 799, 751cm⁻¹ I-711 foam ¹H NMR(CDCl₃) δ 2.85(s, 3H), 3.22(s, 3H), 3.30(s, 3H), 3.54(s, 3H), 3.78(s, 3H), 5.02(s, 2H), 6.85(s, 1H), 7.08(d, J=8.4Hz, 1H), 7.32(d, J=2.1Hz, 1H), 7.37(dd, J=8.4, 2.1Hz, 1H), 7.39(d, J=8.7Hz, 2H), 7.67(d, J=8.7Hz, 2H) IR(Nujol) 3423, 3320, 3215, 1610, 1519, 1480, 1454, 1176, 1151, 1080, 969, 876, 798cm⁻¹ I-712 foam ¹H NMR(CDCl₃) δ 2.62(s, 3H), 3.45(s, 3H), 3.74(s, 3H), 5.28(s, 2H), 6.45(s, 1H), 6.92(d, J=8.7Hz, 2H), 6.95(dd, J=8.4, 2.1Hz, 1H), 7.10(d, J=8.4Hz, 1H), 7.11(d, J=2.1Hz, 1H), 7.53(d, J=8.7Hz, 2H), 8.50(brs, 1H), 8.60(brs, 1H) IR(Nujol) 3207, 1611, 1589, 1523, 1489, 1460, 1227, 1116, 1072, 1014, 943, 822, 759cm⁻¹ I-713 mp 231–233° C. ¹H NMR(CDCl₃) δ 3.30(s, 3H), 3.64(s, 3H), 5.28(s, 2H), 6.39(s, 1H), 6.67(dd, J=8.4, 2.1Hz, 1H), 6.80(d, J=2.1Hz, 1H), 6.84(d, J=8.7Hz, 2H), 7.01(d, J=8.4Hz, 1H), 7.44(d, J=8.7Hz, 2H), 8.64(d, J=2.4Hz, 1H), 8.67(dd, J=2.4, 1.2Hz, 1H), 8.94(d, J=1.2Hz, 1H) IR(Nujol) 3369, 3164, 1612, 1600, 1585, 1522, 1493, 1385, 1255, 1118, 1073, 1013, 934, 824, 798, 778cm⁻¹ I-714 foam ¹H NMR(CDCl₃) δ 2.83(s, 3H), 3.22(s, 3H), 3.27(s, 3H), 3.55(s, 3H), 3.78(s, 3H), 5.18(s, 2H), 6.85(s, 1H), 7.20(d, J=8.4Hz, 1H), 7.39(d, J=8.7Hz, 2H), 7.40(dd, J=8.4, 2.1Hz, 1H), 7.45(d, J=2.1Hz, 1H), 7.67(d, J=8.7Hz, 2H) IR(Nujol) 3264, 1650, 1607, 1517, 1480, 1175, 1150, 1078, 946, 876, 798cm⁻¹

TABLE 141 I-715 foam ¹H NMR(CDCl₃) δ 2.76(s, 3H), 2.77(s, 3H), 3.21(s, 3H), 3.24(s, 3H), 3.55(s, 3H), 3.78(s, 3H), 5.35(s, 2H), 6.84(s, 1H), 7.25(d, J=8.4Hz, 1H), 7.38(d, J=8.7Hz, 2H), 7.38(dd, J=8.4, 2.1Hz, 1H), 7.44(d, J=2.1Hz, 1H), 7.68(d, J=8.7Hz, 2H) IR(Nujol) 1607, 1578, 1519, 1465, 1176, 1151, 1079, 971, 947, 876, 846, 797cm⁻¹ I-716 mp 227–229° C. ¹H NMR(DMSO-d₆) δ 2.87(s, 3H), 3.39(s, 3H), 3.45(s, 3H), 3.52(s, 3H), 3.79(s, 3H), 5.23(s, 2H), 7.08(s, 1H), 7.33(d, J=2.1Hz, 1H), 7.35(dd, J=8.4, 2.1Hz, 1H), 7.44(d, J=8.4Hz, 1H), 7.49(d, J=8.7Hz, 2H), 7.74(d, J=8.7Hz, 2H) IR(Nujol) 3276, 1651, 1605, 1520, 1480, 1463, 1174, 1150, 1079, 947, 879, 798cm⁻¹ I-717 m.p 180–181° C. ¹H NMR(CDCl₃) δ 3.07(s, 3H), 3.45(s, 3H), 3.75(s, 3H), 5.18(s, 2H), 6.45(s, 1H), 6.92(d, J=8.7Hz, 2H), 6.99(dd, J=1.8, 8.4Hz, 1H), 7.08(d, J=1.8Hz, 1H), 7.10(d, J=8.4Hz, 1H), 7.25(t, J=7.2Hz, 1H), 7.44(m, 2H), 7.53(d, J=8.7Hz, 2H), 7.61(d, J=8.1Hz, 1H) I-718 foam ¹H NMR(CDCl₃) δ 3.06(s, 3H), 3.45(s, 3H), 3.74(s, 3H), 5.17(s, 2H), 6.45(s, 1H), 6.93(d, J=8.7Hz, 2H), 6.98(dd, J=8.7Hz, 1H), 7.08(d, J=2.1Hz, 1H), 7.10(d, J=8.4Hz, 1H), 7.24(m, 1H), 7.43(m, 2H), 7.51(d, J=8.7Hz, 2H), 7.61(m, 1H) IR(KBr) 3430, 1611, 1590, 1523, 1490, 1402, 1323, 1242, 1149, 1112, 1070, 1010, 971, 826cm⁻¹ I-719 foam ¹H NMR(CDCl₃) δ 2.80(s, 6H), 3.47(s, 3H), 3.76(s, 3H), 5.08(s, 2H), 6.46(s, 1H), 6.92(d, J=8.7Hz, 3H), 7.10(d, J=2.1Hz, 1H), 7.15(d, J=8.7Hz, 1H), 7.20(d, J=7.2Hz, 1H), 7.34–7.45(m, 3H), 7.55(d, J=8.7Hz, 2H) IR(KBr) 3427, 1611, 1585, 1522, 1488, 1404, 1224, 1113, 1069, 1011, 940, 824, 767cm⁻¹

TABLE 142 I-720 foam ¹H NMR(CDCl₃) δ 1.52(s, 9H), 2.67(s, 3H), 3.19(s, 3H), 3.21(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 5.17(s, 2H), 6.54(br.s, IH), 7.11(m, 1H), 7.12(d, J=9.0Hz, 1H), 7.25(m, 1H), 7.30(d, J=7.5Hz, 1H), 7.32(dd, J=1.8, 9.0Hz, 1H), 7.36(d, J=8.7Hz, 2H), 7.41(d, J=1.8Hz, 1H), 7.60(s, 1H), 7.67(d, J=8.7Hz, 2H) IR(KBr) 1724, 1610, 1520, 1481, 1366, 1234, 1177, 1153, 1079, 969, 875, 797cm⁻¹ I-721 m.p 187–191° C. ¹H NMR(CDCl₃) δ 2.66(s, 3H), 3.17(s, 3H), 3.21(s, 3H), 3.55(s, 3H), 3.78(s, 3H), 5.11(s, 2H), 6.65(d, J=8.4Hz, 1H), 6.81(m, 2H), 6.84(s, 1H), 7.12(d, J=8.7Hz, 1H), 7.17(t, J=8.7Hz, 1H), 7.32(dd, J=2.1, 8.7Hz, 1H), 7.37(d, J=8.7Hz, 2H), 7.40(d, J=2.1Hz, 1H), 7.67(d, J=8.7Hz, 2H) IR(KBr) 1624, 1606, 1519, 1481, 1361, 1176, 1148, 1081, 980, 876, 780cm⁻¹ I-722 m.p 143–146° C. ¹H NMR(CDCl₃) δ 2.18(s, 3H), 2.71(s, 3H), 3.18(s, 3H), 3.21(s, 3H), 3.55(s, 3H), 3.78(s, 3H), 5.18(s, 2H), 6.84(s, 1H), 7.12(d, J=8.7Hz, 1H), 7.17(d, J=7.2Hz, 1H), 7.33(m, 2H), 7.37(d, J=8.7Hz, 2H), 7.41(d, J=2.1Hz, 1H), 7.45(d, J=7.2Hz, 1H), 7.67(d, J=8.7Hz, 2H), 7.67(m, 1H) IR(KBr) 1693, 1609, 1519, 1481, 1364, 1364, 1173, 1149, 1079, 874, 802cm⁻¹ I-723 foam ¹H NMR(CDCl₃) δ 2.86(s, 3H), 3.00(s, 3H), 3.22(s, 3H), 3.55(s, 3H), 3.78(s, 3H), 5.22(s, 2H), 6.59(s, 1H), 6.85(s, 1H), 7.10(d, J=8.4Hz, 1H), 7.25(m, 3H), 7.32(d, J=2.1, 8.7Hz, 1H), 7.37(m, 1H), 7.38(d, J=2.1Hz, 1H), 7.38(d, J=8.7Hz, 1H), 7.67(d, J=8.7Hz, 2H) IR(KBr) 1610, 1519, 1480, 1364, 1176, 1150, 1079, 971, 876, 797cm⁻¹

TABLE 143 I-724 foam ¹H NMR(CDCl₃ ) δ 2.74(s, 3H), 3.18(s, 3H), 3.21(s, 3H), 3.43(s, 6H), 3.55(s, 3H), 3.78(s, 3H), 5.24(s, 2H), 6.84(s, 1H), 7.13(d, J=8.4Hz, 1H), 7.36(dt, J=2.1, 8.4Hz, 1H), 7.37(m, 1H), 7.39(d, J=8.7Hz, 2H), 7.40(d, J=2.1Hz, 1H), 7.51(m, 2H), 7.61(s, 1H), 7.67(d, J=8.7Hz, 2H) IR(KBr) 1609, 1523, 1481, 1353, 1176, 1161, 1080, 890, 799cm⁻¹ I-725 m.p 147–150° C. ¹H NMR(CDCl₃) δ 2.79(s, 3H), 2.83(s, 3H), 3.20(s, 3H), 3.21(s, 3H), 3.35(s, 3H), 3.55(s, 3H), 3.78(s, 3H), 5.22(s, 2H), 6.85(s, 1H), 7.11(d, J=8.7Hz, 1H), 7.32–7.46(m, 7H), 7.62(s, 1H), 7.67(d, J=8.4Hz, 2H) IR(KBr) 1608, 1518, 1480, 1364, 1178, 1153, 1077, 968, 795cm⁻¹ I-726 m.p 224–226° C. ¹H NMR(CDCl₃) δ 2.85(s, 3H), 2.91(s, 6H), 3.36(s, 3H), 3.45(s, 3H), 3.51(s, 3H), 3.78(s, 3H), 5.19(s, 2H), 6.69(d, J=8.1Hz, 1H), 6.76(d, J=8.1Hz, 1H), 6.89(s, 1H), 7.07(s, 1H), 7.20(t, J=8.1Hz, 1H), 7.30(m, 3H), 7.48(d, J=8.7Hz, 2H), 7.74(d, J=8.7Hz, 2H) IR(KBr) 1608, 1519, 1480, 1360, 1178, 1146, 1081, 879, 826cm⁻¹ I-727 foam ¹H NMR(CDCl₃) δ 2.82(s, 3H), 3.18(s, 6H), 3.21(s, 3H), 3.53(s, 3H), 3.76(s, 3H), 5.17(s, 2H), 6.84(s, 1H), 7.11(d, J=8.4Hz, 1H), 7.20(d, J=4.8Hz, 1H), 7.30–7.47(m, 8H), 7.76(d, J=8.7Hz, 2H) IR(KBr) 3430, 1677, 1609, 1519, 1481, 1364, 1202, 1177, 1150, 1079, 876, 799cm⁻¹ I-728 foam ¹H NMR(CDCl₃) δ 3.45(s, 3H), 3.75(s, 3H), 5.06(s, 2H), 6.45(s, 1H), 6.68(d, J=7.5Hz, 1H), 6.77(s, 1H), 6.82(d, J=7.5Hz, 1H), 6.91(d, J=8.7Hz, 2H), 6.93(dd, J=1.8, 8.4Hz, 1H), 6.99(d, J=8.4Hz, 1H), 7.07(d, J=1.8Hz, 1H), 7.19(t, J=7.5Hz, 1H), 7.54(d, J=8.7Hz, 2H) IR(KBr) 3413, 1611, 1522, 1488, 1461, 1405, 1251, 1119, 1076, 1007, 813, 784cm⁻¹

TABLE 144 I-729 m.p 90–93° C. ¹H NMR(CDCl₃) δ 3.01(s, 3H), 3.45(s, 3H), 3.75(s, 3H), 5.16(s, 2H), 6.45(s, 1H), 6.81(s, 1H), 6.92(d, J=8.7Hz, 2H), 6.95(d, J=1.8Hz, 1H), 6.96(m, 2H), 7.24(m, 2H), 7.40(t, J=7.2Hz, 1H), 7.52(d, J=8.7Hz, 2H) IR(KBr) 3434, 1612, 1592, 1523, 1489, 1325, 1248, 1224, 1147, 1113, 1070, 1010, 972cm⁻¹ I-730 mp 79–81° C. ¹H NMR(CDCl₃) δ 2.34(s, 6H), 3.48(s, 3H), 3.76(s, 3H), 4.72(brs, 1H), 5.16(s, 2H), 5.68(brs, 1H), 5.93(brs, 1H), 6.44 (s, 1H), 6.99–7.10(m, 3H), 7.26–7.49(m, 7H) IR(KBr) 3467, 2933, 1613, 1701, 1517, 1482, 1454, 1424, 1389, 1321, 1196, 1148, 1113, 1073cm⁻¹ I-731 mp 189–191° C. ¹H NMR(CDCl₃) δ 3.20(s, 3H), 3.81(s, 6H), 5.14(s, 2H), 5.65(brs, 1H), 6.79(s, 2H), 6.79–7.02(m, 5H), 7.36–7.46(m, 6H), 7.66(d, J=8.6Hz, 2H) IR(KBr) 3439, 2937, 1594, 1567, 1523, 1487, 1351, 1240, 1202, 1146, 1126, 874cm⁻¹ I-732 mp 196–197° C. ¹H NMR(DMSO-d₆) δ 3.32(s, 3H), 3.43(s, 6H), 3.79(s, 6H), 5.24(s, 2H), 7.00(s, 2H), 7.23–7.30(m, 3H), 7.35–7.55(m, 7H), 7.88(d, J=8.4Hz, 2H) IR(KBr) 3434, 1602, 1561, 1523, 1485, 1362, 1288, 1238, 1201, 1181, 1148, 1126, 1115, 966, 914, 813cm⁻¹ I-733 mp 202–203° C. ¹H NMR(DMSO-d₆) δ 2.40(s, 6H), 3.31(s, 3H), 3.34(s, 3H), 3.51(s, 3H), 3.58(s, 3H), 3.77(s, 3H), 5.27(s, 2H), 7.03(s, 1H), 7.32–7.530(m, 10H) IR(KBr) 3434, 3028, 2944, 1515, 1475, 1463, 1361, 1290, 1272, 1247, 1179, 1085, 967, 815, 804cm⁻¹

TABLE 145 I-734 mp 140–141° C. ¹H NMR(CDCl₃) δ 1.77(s, 3H), 1.82(s, 3H), 3.21(s, 3H), 3.83(s, 6H), 4.63(d, J=4.6Hz, 2H), 5.52–5.53(m, 1H), 6.79(s, 2H), 7.05(d, J=8.8Hz, 1H), 7.29–7.42(m, 4H), 7.67(d, J=8.6Hz, 2H) IR(KBr) 3434, 2936, 1602, 1565, 1487, 1365, 1242, 1182, 1152, 1123, 1113, 974, 874, 811cm⁻¹ I-735 mp 168–169° C. ¹H NMR(CDCl₃) δ 2.38(s, 3H), 3.09(s, 3H), 3.20(s, 3H), 3.81(s, 6H), 5.11(s, 2H), 6.78(s, 2H), 7.13–7.42(m, 9H), 7.66(d, J=8.8Hz, 2H) IR(KBr) 3433, 1601, 1566, 1486, 1367, 1246, 1182, 1153, 1114, 973, 869, 824cm⁻¹ I-736 mp 192–194° C. ¹H NMR(CDCl₃) δ 1.77(s, 3H), 1.82(s, 3H), 2.47(s, 6H), 2.72(s, 3H), 3.24(s, 3H), 3.36(s, 3H), 3.57(s, 3H), 3.79(s, 3H), 4.64(d, J=6.6Hz, 2H), 5.47–5.55(m, 1H), 6.83(s, 1H), 7.09(d, J=9.0Hz, 1H), 7.33–7.40(m, 4H) IR(KBr) 3435, 1942, 1516, 1474, 1382, 1357, 1288, 1178, 1096, 966, 862, 805cm⁻¹ I-737 mp 224–225° C. ¹H NMR(CDCl₃) δ 2.38(s, 3H), 2.46(s, 6H), 2.66(s, 3H), 3.12(s, 3H), 3.35(s, 3H), 3.55(s, 3H), 3.77(s, 3H), 5.14(s, 2H), 6.82(s, 1H), 7.12–7.40(m, 9H) IR(KBr) 3435, 2941, 1518, 1474, 1360, 1274, 1179, 1095, 1085, 967, 862, 815, 805cm⁻¹ I-738 mp 203–204° C. ¹H NMR(CDCl₃) δ 1.76(s, 3H), 1.82(s, 3H), 2.46(s, 6H), 2.45–2.58(m, 2H), 2.73(s, 3H), 3.22(s, 3H), 3.35(s, 3H), 3.55(s, 3H), 3.77(s, 3H), 4.07(d, J=6.6Hz, 2H), 5.18–5.25(m, 1H), 6.82(s, 1H), 7.07(d, J=8.2Hz, 1H), 7.32–7.39(m, 4H) IR(KBr) 3434, 2941, 1519, 1473, 1359, 1276, 1178, 1114, 1085, 967, 860, 811cm⁻¹

TABLE 146 I-739 mp 158–159° C. ¹H NMR(DMSO-d₆) δ 1.72(s, 3H), 1.76(s, 3H), 3.72(s, 6H), 4.54(d, J=6.0Hz, 2H), 5.45–5.52(m, 1H), 6.55–6.59(m, 2H), 6.84–6.90(m, 5H), 7.57(d, J=8.2Hz, 2H), 8.70(brs, 1H), 9.53(brs, 1H) IR(KBr) 3465, 2932, 1610, 1523, 1487, 1460, 1283, 1281, 1123, 1010, 819cm⁻¹ I-740 mp 180–181° C. ¹H NMR(CDCl₃) δ 2.32(s, 3H), 3.72(s, 6H), 5.08(s, 2H), 6.54–6.58(m, 1H), 6.68(s, 1H), 6.85–6.95(m, 5H), 7.21(d, J=7.6Hz, 2H), 7.39(d, J=7.8Hz, 2H), 7.57(d, J=8.4Hz, 2H), 8.83(brs, 1H), 9.54(brs, 1H) IR(KBr) 3519, 2937, 1607, 1562, 1523, 1461, 1400, 1246, 1176, 1125, 1003, 821cm⁻¹ I-741 mp 105–106° C. ¹H NMR(CDCl₃) δ 2.13(s, 6H), 3.17(s, 3H), 5.16(s, 2H), 5.85(brs, 1H), 6.61–6.66(m, 1H), 6.77(s, 1H), 7.01(d, J=8.2Hz, 1H), 7.25–7.46(m, 9H), 7.65(d, J=8.8Hz, 2H) IR(KBr) 3466, 3031, 2934, 1585, 1513, 1476, 1366, 1285, 1198, 1175, 1148, 1127, 1014, 968, 868, 840cm⁻¹ I-742 mp 92–93° C. ¹H NMR(DMSO-d₆) δ 1.74(s, 3H), 1.78(s, 3H), 2.24(s, 6H), 3.31(s, 3H), 3.65(s, 3H), 4.56(d, J=6.8Hz, 2H), 5.52(t, J=6.0Hz, 1H), 6.37(s, 1H), 6.64–6.76(m, 2H), 6.88–6.93(m, 1H), 7.16–7.20(m, 2H), 8.31(brs, 1H), 8.45(brs, 1H), 8.73(brs, 1H) IR(KBr) 3443, 2932, 1707, 1613, 1516, 1484, 1462, 1387, 1280, 1243, 1196, 1114, 1074, 979cm⁻¹ I-743 mp 180–181° C. ¹H NMR(DMSO-d₆) δ 2.22(s, 6H), 2.32(s, 3H), 3.29(s, 3H), 3.63(s, 3H), 5.08(s, 2H), 6.61–6.65(m, 1H), 6.75(s, 1H), 6.93 (d, J=8.2Hz, 1H), 7.13–7.22(m, 4H), 7.39(d, J=7.4Hz, 2H), 8.30(brs, 1H), 8.44(brs, 1H), 8.84(brs, 1H) IR(KBr) 3443, 2930, 1686, 1614, 1587, 1518, 14863, 1462, 1385, 1281, 1246, 1197, 1113, 1073, 1009, 806cm⁻¹

TABLE 147 I-744 mp 123–124° C. ¹H NMR(DMSO-d₆) δ 1.65(s, 3H), 1.71(s, 3H), 2.23(s, 6H), 2.36–2.51(m, 2H), 3.31(s, 3H), 3.64(s, 3H), 3.91–3.98(m, 2H), 5.22–5.28(m, 1H), 6.36(s, 1H), 6.65–6.88(m, 3H), 7.16(s, 1H), 8.30(brs, 1H), 8.44(brs, 1H), 8.70(brs, 1H) IR(KBr) 3444, 2930, 1686, 1613, 1518, 1483, 1390, 1283, 1248, 1198, 1113, 1074, 1013cm⁻¹ I-745 mp 174–177° C. ¹H NMR(CDCl₃) δ 1.77–1.78(d, J=0.9Hz, 3H), 1.82–1.83(d, J=0.9Hz, 3H), 2.74(s, 3H), 3.18(s, 3H), 3.25(s, 3H), 3.57 (s, 3H), 3.78(s, 2H), 4.64–4.67(d, J=6.9Hz, 2H), 5.51(m, 1H), 6.86(s, 1H), 7.09(d, J=8.4Hz, 1H), 7.35–7.40(m, 2H), 7.45–7.49(m, 2H), 7.55–7.60(m, 2H) IR(CHCl₃) 2939, 1613, 1519, 1480, 1371, 1331, 1292, 1251, 1176, 1150, 1118, 1082, 971, 871, 849cm⁻¹ I-746 mp 134–136° C. ¹H NMR(CDCl₃) δ 1.69(s, 3H), 1.75(s, 3H), 2.53–2.60(dt, J=6.6, 5.7Hz, 2H), 2.73(s, 3H), 3.18(s, 3H), 3.23(s, 3H), 3.56 (s, 3H), 3.78(s, 3H), 4.07–4.11(t, J=5.7Hz, 2H), 5.22(m, 1H), 6.86(s, 1H), 7.07(d, J=9.0Hz, 1H), 7.35–7.40(m, 2H), 7.45–7.49(m, 2H), 7.55–7.61(m, 2H) IR(CHCl₃) 2938, 1614, 1519, 1480, 1448, 1371, 1331, 1294, 1228, 1176, 1150, 1119, 1083, 1004, 970, 870, 849, 819cm⁻¹ I-747 mp 182–183° C. ¹H NMR(CDCl₃) δ 2.26(s, 3H), 2.28(s, 3H), 4.74(s, 1H), 5.16(s, 2H), 5.69(s, 1H), 6.81–6.89(m, 3H), 6.96–6.99(m, 2H), 7.10–7.12(d, J=4.8Hz, 2H), 7.23–7.26(m, 2H), 7.39–7.45(m, 5H) IR(CHCl₃) 3597, 3543, 2924, 2871, 1611, 1587, 1522, 1490, 1455, 1382, 1171, 1126, 1012, 836cm⁻¹ I-748 mp 158–161° C. ¹H NMR(CDCl₃) δ 2.38(s, 3H), 2.74(s, 3H), 3.12(s, 3H), 3.18(s, 3H), 3.57(s, 3H), 3.78(s, 3H), 5.15(s, 2H), 6.86(s, 1H), 7.16(d, J=8.7Hz, 1H), 7.21–7.24(d, J=7.8Hz, 1H), 7.35–7.40(m, 5H), 7.45–7.49(m, 2H), 7.52–7.62(m, 2H) IR(CHCl₃) 2939, 1732, 1614, 1519, 1480, 1331, 1294, 1253, 1176, 1150, 1119, 1082, 1003, 970, 869, 816cm⁻¹

TABLE 148 I-749 mp 174–176° C. ¹H NMR(CDCl₃) δ 1.75(s, 3H), 1.79(s, 3H), 2.58(s, 3H), 3.52(s, 3H), 3.53(s, 3H), 3.78(s, 3H), 4.62(d, J=6.9Hz, 2H), 5.48–5.55(m, 1H), 6.83(s, 1H), 6.99(d, J=8.7Hz, 1H), 7.09(dd, J=1.8, 8.1Hz, 1H), 7.11–7.19(m, 2H), 7.22(d, J=1.8Hz, 1H), 7.57–7.65(m, 2H) IR(KBr) 2932, 1602, 1519, 1485, 1385, 1368, 1174, 1086, 1015, 986, 848, 804, 527cm⁻¹ I-750 mp 129–131° C. ¹H NMR(CDCl₃) δ 1.75(s, 3H), 1.79(s, 3H), 3.45(s, 3H), 3.53(s, 3H), 3.75(s, 3H), 4.62(d, J=6.6Hz, 2H), 5.24(s, 2H), 5.50–5.58(m, 1H), 5.90(s, 1H), 6.44(s, 1H), 6.99(d, J=8.7Hz, 1H), 7.08–7.18(m, 3H), 7.29(d, J=1.8Hz, 1H), 7.58–7.64(m, 2H) IR(KBr) 3361, 2953, 2934, 1522, 1488, 1460, 1391, 1230, 1154, 1121, 1071, 993, 912, 817, 587cm⁻¹ I-751 mp 148–150° C. ¹H NMR(CDCl₃) δ 1.68(s, 3H), 1.74(s, 3H), 2.51–2.60(m, 5H), 3.53(s, 6H), 3.77(s, 3H), 4.02(t, J=7.2Hz, 2H), 5.19–5.25 (m, 3H), 6.83(s, 1H), 6.98(d, J=8.4Hz, 1H), 7.08(dd, J=2.1, 8.4Hz, 1H), 7.11–7.18(m, 2H), 7.21(d, J=2.1Hz, 1H), 7.57–7.64(m, 2H) IR(KBr) 2931, 1603, 1519, 1484, 1386, 1370, 1231, 1175, 1086, 1015, 983, 961, 847, 728, 526cm⁻¹ I-752 mp 99–101° C. ¹H NMR(CDCl₃) δ 1.68(s, 3H), 1.73(s, 3H), 2.55(q, J=7.2Hz, 2H), 3.44(s, 3H), 3.54(s, 3H), 3.75(s, 3H), 4.04(t, J=7.2Hz, 2H), 5.20–5.25(m, 3H), 5.89(s, 1H), 6.44(s, 1H), 6.98(d, J=8.1Hz, 1H), 7.09–7.18(m, 3H), 7.26–7.27(m, 1H), 7.58–7.63 (m, 2H) IR(KBr) 3349, 2930, 1609, 1523, 1489, 1231, 1152, 1121, 1072, 994, 912, 813, 588cm⁻¹

TABLE 149 I-753 mp 115–117° C. ¹H NMR(CDCl₃) δ 1.69(s, 3H), 1.75(s, 3H), 2.53(q, J=6.9Hz, 2H), 2.62(s, 3H), 3.53(s, 3H), 3.77(s, 3H), 4.06(t, J=6.9Hz, 2H), 5.18–5.25(m, 1H), 5.70(s, 1H), 6.83(s, 1H), 6.89–6.95(m, 2H), 7.02(d, J 1.2Hz, 1H), 7.10–7.18(m, 2H), 7.57–7.65 (m, 2H) IR(KBr) 3545, 2931, 1604, 1520, 1485, 1370, 1249, 1232, 1175, 1084, 1012, 813, 526cm⁻¹ I-754 ¹H NMR(CDCl₃) δ 1.14(t, J=6.9Hz, 3H), 1.29(t, J=6.9Hz, 3H), 2.50(s, 3H), 3.19(s, 3H), 3.71(q, J=6.9Hz, 2H), 4.00 (q, J=6.9Hz, 2H), 5.18(s, 2H), 5.68(s, 1H), 6.83(s, 1H), 6.91(dd, J=1.8, 8.4Hz, 1H), 7.00(d, J=8.4Hz, 1H), 7.04(d, J=1.8Hz, 1H), 7.32–7.48(m, 7H), 7.66–7.74(m, 2H) IR(CHCl₃) 3532, 2976, 1586, 1516, 1468, 1369, 1282, 1174, 1148, 1068, 1016, 967, 907, 871cm⁻¹ I-755 amorphous powder ¹H NMR(CDCl₃) δ 1.15(t, J=6.9Hz, 3H), 1.28(t, J=6.9Hz, 3H), 3.59(q, J=6.9Hz, 2H), 3.97(q, J=6.9Hz, 2H), 4.89 (s, 1H), 5.15(s, 2H), 5.64(s, 1H), 5.98(s, 1H), 6.45(s, 1H), 6.86–6.94(m, 2H), 6.96–7.04(m, 2H), 7.12(d, J=2.4Hz, 1H), 7.35–7.56(m, 7H), IR(CHCl₃) 3534, 1610, 1521, 1488, 1383, 1169, 1116, 1064, 1018, 832cm⁻¹ I-756 mp 126–129° C. ¹H NMR(CDCl₃) δ 1.14(t, J=6.9Hz, 3H), 1.30(t, J=6.9Hz, 3H), 1.76(s, 3H), 1.81(s, 3H), 2.69(s, 3H), 3.20(s, 3H), 3.23(s, 3H), 3.72(q, J=6.9Hz, 2H), 4.00(q, J=6.9Hz, 2H), 4.64(d, J=6.6Hz, 2H), 5.49(m, 1H), 6.84(s, 1H), 7.08(d, J=8.7Hz, 1H), 7.32–7.42(m, 4H), 7.56–7.72(m, 2H) IR(CHCl₃) 1609, 1516, 1467, 1369, 1267, 1229, 1175, 1148, 1115, 1069, 968, 907, 871cm⁻¹

TABLE 150 I-757 mp 123–135° C.(dec.) ¹H NMR(CDCl₃) δ 1.14(t, J=6.9Hz, 3H), 1.29(t, J=6.9Hz, 3H), 2.37(s, 3H), 2.64(s, 3H), 3.12(s, 3H), 3.20(s, 3H), 3.71(q, J=6.9Hz, 2H), 4.00(q, J=6.9Hz, 2H), 5.14(s, 2H), 6.83(s, 1H), 7.14(d, J=8.7Hz, 1H), 7.18–7.24(m, 2H), 7.31–7.40 (m, 5H), 7.41(d, J=2.1Hz, 1H), 7.65–7.72(m, 2H) IR(CHCl₃)1607, 1517, 1467, 1369, 1330, 1268, 1175, 1148, 1116, 1069, 1026, 967, 907, 871cm⁻¹ I-758 amorphous powder ¹H NMR(CDCl₃) δ 1.15(t, J=6.9Hz, 3H), 1.28(t, J=6.9Hz, 3H), 1.76(s, 3H), 1.82(d, J=0.6Hz, 3H), 3.59(q, J=6.9Hz, 2H), 3.97(q, J=6.9Hz, 2H), 4.61(d, J=6.9Hz, 2H), 4.87(s, 1H), 5.53(m, 1H), 5.66(s, 1H), 5.97(s, 1H), 6.45(s, 1H), 6.86–7.00(m, 4H), 7.09(d, J=1.8Hz, 1H), 7.50–7.57(m, 2H) IR(CHCl₃)3528, 2978, 1611, 1521, 1487, 1412, 1383, 1168, 1115, 1064, 905, 831cm⁻¹ I-759 amorphous powder ¹H NMR(CDCl₃) δ 1.15(t, J=6.9Hz, 3H), 1.27(t, J=6.9Hz, 3H), 2.39(s, 3H), 3.59(q, J=6.9Hz, 2H), 3.97(q, J=6.9Hz, 2H), 4.88(s, 1H), 5.10(s, 2H), 5.64(s, 1H), 5.97(s, 1H), 6.45(s, 1H), 6.97–7.01(m, 2H), 7.11(d, J=1.5Hz, 1H), 7.20–7.26 (m, 2H), 7.32–7.37(m, 2H), 7.50–7.56(m, 2H) IR(CHCl₃)3526, 2974, 1612, 1520, 1488, 1412, 1383, 1285, 1246, 1116, 1065, 1027, 870cm⁻¹ I-760 mp 169–171° C. ¹H NMR(CDCl₃) δ 2.71(s, 3H), 3.01(s, 3H), 3.10(s, 3H), 3.21(s, 3H), 3.36(s, 3H), 3.56(s, 3H), 3.77(s, 3H), 4.83(s, 2H), 6.84(s, 1H), 7.05(d, J=8.4Hz, 1H), 7.32(dd, J=2.1, 8.4Hz, 1H), 7.36–7.42(m, 2H), 7.42(d, J=2.1Hz, 1H), 7.65–7.72 (m, 2H) IR(CHCl₃)1666, 1517, 1479, 1368, 1175, 1148, 1119, 1083, 1014, 968, 871cm⁻¹

TABLE 151 I-761 mp 175–177° C. ¹H NMR(DMSO-d₆) δ 1.70(s, 6H), 3.67–3.73(m, 2H), 3.71(s, 3H), 3.72(s, 3H), 4.59(br, 1H), 5.27–5.31(m, 1H), 6.50(d, J=8.1Hz, 1H), 6.77–6.95(m, 6H), 7.34–7.40(m, 2H), 9.23(br s, 1H), 9.42(br s, 1H) IR(KBr)3600–2400(br), 1609, 1522, 1492, 1463, 1384, 1263, 1208, 1174, 1129, 1055, 1033cm⁻¹ I-762 mp 151–153° C. ¹H NMR(CDCl₃) δ 1.78(s, 3H), 1.85(s, 3H), 3.78(s, 3H), 3.80(s, 3H), 4.72(d, J=6.9Hz, 2H), 5.39–5.44(m, 1H), 6.53(d, J=3.0Hz, 1H), 6.95(s, 1H), 7.05(s, 1H), 7.09–7.16(m, 3H), 7.38(d, J=8.7Hz, 1H), 7.45(dd, J=1.8, 8.7Hz, 1H), 7.54–7.60 (m, 2H), 7.80(d, J=1.8Hz, 1H), IR(KBr)3600–2800(br), 1509, 1496, 1481, 1462, 1447, 1383, 1207, 1158, 1051cm⁻¹ I-763 mp 138–139° C. ¹H NMR(CDCl₃) δ 3.78(s, 3H), 3.79(s, 3H), 6.64(dd, J=0.9, 2.7Hz, 1H), 6.80(d, J=7.8Hz, 1H), 6.94(s, 1H), 7.04(s, 1H), 7.09–7.21(m, 3H), 7.25–7.27(m, 1H), 7.32(d, J=8.7Hz, 1H), 7.42(dd, J=1.8, 8.4Hz, 1H), 7.53–7.59(m, 3H), 8.60–8.63 (m, 1H) IR(KBr)3600–2800(br), 1590, 1510, 1497, 1478, 1430, 1384, 1209, 1158, 1053, 1026cm⁻¹ I-764 mp 172–174° C. ¹H NMR(CDCl₃) δ 2.32(s, 3H), 3.78(s, 3H), 3.79(s, 3H), 5.30(s, 2H), 6.59(d, J=3.3Hz, 1H), 6.94(s, 1H), 7.04(s, 1H), 7.04–7.15(m, 7H), 7.34(d, J=8.4Hz, 1H), 7.41(dd, J=1.8, 8.7Hz, 1H), 7.55–7.59(m, 2H), 7.82–7.83(m, 1H) IR(KBr)3600–2800(br), 1516, 1497, 1482, 1466, 1382, 1306, 1219, 1209, 1159, 1051, 1026cm⁻¹ I-765 mp 134–136° C. ¹H NMR(DMSO-d₆) δ 1.70(s, 3H), 1.71(s, 3H), 3.72–3.74(m, 2H), 3.73(s, 3H), 3.74(s, 3H), 5.25(br s, 1H), 5.50–5.58(m, 1H), 6.66–6.72(m, 1H), 6.78–6.83(m, 1H), 6.92(s, 3H), 6.95(s, 3H), 7.19–7.29(m, 2H), 7.30–7.39(m, 2H), 9.45(br s, 3H), IR(KBr)3600–2800(br), 1624, 1610, 1526, 1494, 1461, 1382, 1255, 1208, 1175, 1120, 1054, 1031cm⁻¹

TABLE 152 I-766 mp 166–168° C. ¹H NMR(CDCl₃) δ 2.40(s, 3H), 3.77(s, 6H), 4.82(s, 1H), 6.71(d, J=2.4Hz, 1H), 6.86–6.93(m, 4H), 7.22–7.32(m, 4H), 7.43–7.48(m, 2H), 7.58–7.64(m, 1H), 7.71–7.75(m, 2H) IR(KBr)3600–2800(br), 1611, 1524, 1492, 1382, 1336, 1265, 1209, 1162, 1090, 1053, 1030cm⁻¹ I-767 mp 139–140° C. ¹H NMR(CDCl₃) δ 3.78(s, 3H), 3.80(s, 3H), 6.60–6.62(m, 1H), 6.95(s, 1H), 7.05(s, 1H), m), 7.08–7.16(m, 2H), 7.23–7.26 (m, 1H), 7.45(d, J=1.2Hz, 2H), 7.54–7.61(m, 2H), 7.83(d, J=0.6Hz, 1H), 8.18(br s, 1H) IR(KBr)3600–2800(br), 1520, 1497, 1465, 1448, 1414, 1383, 1313, 1218, 1205, 1159, 1048, 1024cm⁻¹ I-768 ¹H NMR(CDCl₃) δ 2.26(s, 3H), 3.48(s, 3H), 3.75(s, 3H), 5.16(s, 2H), 5.69(s, 1H), 5.89(s, 1H), 6.45(s, 1H), 6.94(d.d, J=8.4 & 2.1Hz, 1H), 7.02(d, J=8.4Hz, 1H), 7.08(d, J=2.1Hz, 1H), 7.35–7.50(m, 8H), 8.36–8.44(m, 1H) IR(KBr)3384, 1592, 1525, 1487, 1455, 1397, 1312, 1250, 1122, 1102, 1069, 1011cm⁻¹ I-769 ¹H NMR(CDCl₃) δ 2.26(s, 3H), 2.68(s, 3H), 3.13(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 5.19(s, 2H), 6.84(s, 1H), 7.15(d, J=8.4Hz, 1H), 7.30–7.51(m, 10H), 8.37–8.47(m, 1H) IR(KBr)3384, 1704, 1590, 1524, 1481, 1389, 1357, 1272, 1240, 1174, 1114, 1082, 1017cm⁻¹ I-770 ¹H NMR(CDCl₃) δ 2.67(s, 3H), 2.84(s, 3H), 3.28(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 6.26(s, 1H), 6.85(s, 1H), 7.17(d, J=9.0Hz, 1H), 7.24–7.33(m, 2H), 7.35–7.50(m, 3H), 8.37–8.50(m, 1H) IR(KBr)3383, 1674, 1595, 1526, 1482, 1363, 1177, 1078, 1012cm⁻¹ I-771 ¹H NMR(CDCl₃) δ 1.76(s, 3H), 1.81(s, 3H), 2.26(s, 3H), 2.72(s, 3H), 3.23(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 4.64(d, J=7.2Hz, 2H), 5.44–5.53(m, 1H), 6.84(s, 1H), 7.09(d, J=8.4Hz, 1H), 7.30–7.53(m, 5H), 8.38–8.47(m, 1H) IR(KBr)3376, 1697, 1594, 1524, 1481, 1365, 1270, 1239, 1177, 1112, 1079, 1013cm⁻¹

TABLE 153 I-772 ¹H NMR(CDCl₃) δ 2.26(s, 3H), 2.38(s, 3H), 2.68(s, 3H), 3.12(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 5.14(s, 2H), 6.84(s, 1H), 7.12–7.50(m, 9H), 8.35–8.44(m, 1H) IR(KBr)3365, 1693, 1622, 1591, 1526, 1477, 1374, 1314, 1291, 1180, 1165, 1111, 1078cm⁻¹ I-773 ¹H NMR(CDCl₃) δ 1.76(s, 3H), 1.82(s, 3H), 2.26(s, 3H), 3.48(s, 3H), 3.75(s, 3H), 4.62(d, J=6.9Hz, 2H), 5.46–5.58 (m, 1H), 5.71(s, 1H), 5.86(s, 1H), 6.44(s, 1H), 6.87–7.00(m, 2H), 7.05(.d, J=1.8Hz, 1H), 7.33–7.52(m, 3H), 8.36–8.47 (m, 1H) IR(KBr)1737, 1604, 1519, 1482, 1392, 1366, 1267, 1173, 1131, 1084, 1062, 1009cm⁻¹ I-774 ¹H NMR(CDCl₃) δ: 2.25(s, 3H), 2.38(s, 3H), 3.48(s, 3H), 3.75(s, 3H), 5.10(s, 2H), 5.12(brs, 1H), 5.90(s, 1H), 6.44(s, 1H), 6.94(.d.d, J=8.4 & 1.8Hz, 1H), 7.02(.d, J=8.4Hz, 1H), 7.06(.d, J=1.8Hz, 1H), 7.18–7.52(m, 6H), 8.35–8.44(m, 1H) IR(KBr)1686, 1590, 1524, 1488, 1398, 1314, 1257, 1102, 1068, 1008cm⁻¹ I-775 ¹H NMR(CDCl₃) δ 3.47(s, 3H), 3.76(s, 3H), 5.16(s, 2H), 5.71(s, 1H), 5.82(s, 1H), 6.45(s, 1H), 6.97(d.d, J=8.4 & 2.1Hz, 1H), 7.04(d, J=8.4Hz, 1H), 7.07(d, J=2.1Hz, 1H), 7.22–7.30(m, 1H), 7.33–7.49(m, 5H), 7.92–7.98(m, 1H), 8.09–8.14 (m, 1H), 10.44(s, 1H) IR(KBr)3492, 3459, 1692, 1605, 1518, 1486, 1388, 1294, 1238, 1200, 1115, 1100, 1070, 1008cm⁻¹ I-776 ¹H NMR(CDCl₃) δ 2.35(d, J=1.8Hz, 3H), 2.68(s, 3H), 3.13(s, 3H), 3.23(s, 3H), 3.78(s, 3H), 5.19(s, 2H), 6.82(s, 1H), 7.04–7.17(m, 2H), 7.30–7.49(m, 9H) IR(KBr)1606, 1518, 1478, 1364, 1295, 1271, 1240, 1182, 1118, 1087, 1077, 1017cm⁻¹ I-777 ¹H NMR(CDCl₃) δ 1.76(s, 3H), 1.81(s, 3H), 2.35(s, 3H), 2.72(s, 3H), 3.23(s, 3H), 3.53(s, 3H), 3.78(s, 3H), 4.64(d, J=6.6Hz, 2H), 5.45–5.53(m, 1H), 6.82(s, 1H), 7.03–7.14(m, 2H), 7.32–7.47(m, 4H) IR(KBr)1607, 1520, 1482, 1374, 1363, 1240, 1179, 1115, 1079cm⁻¹

TABLE 154 I-778 ¹H NMR(CDCl₃) δ 2.35(d, J=1.2Hz, 3H), 3.45(s, 3H), 3.75(s, 3H), 5.15(s, 2H), 5.68(s, 1H), 5.90(s, 1H), 6.43(s, 1H), 6.92–7.12(m, 4H), 7.31–7.50(m, 7H) IR(KBr)3536, 3398, 1609, 1587, 1518, 1487, 1244, 1192, 1110, 1071, 1010cm⁻¹ I-779 ¹H NMR(CDCl₃) δ 1.76(s, 3H), 1.82(s, 3H), 2.35(s, 3H), 3.45(s, 3H), 3.74(s, 3H), 4.61(d, J=6.9Hz, 2H), 5.43–5.60(m, 1H), 6.43(s, 1H), 6.87–7.15(m, 4H), 7.36–7.51(m, 2H) IR(KBr)3512, 3444, 1611, 1585, 1518, 1488, 1462, 1447, 1416, 1305, 1288, 1243, 1207, 1112, 1103, 1070, 1012cm⁻¹ I-780 ¹H NMR(CDCl₃) δ 3.45(s, 3H), 3.75(s, 3H), 4.84(s, 2H), 5.15(s, 2H), 5.70(s, 1H), 5.88(s, 1H), 6.44(s, 1H), 6.91–7.20(m, 4H), 7.32–7.48(m, 5H), 7.52–7.61(m, 1H), 7.64–7.74(m, 1H) IR(KBr)3523, 3428, 1610, 1587, 1516, 1482, 1463, 1400, 1321, 1285, 1238, 1187, 1106cm⁻¹ I-781 ¹H NMR(CDCl₃) δ 2.68(s, 3H), 3.13(s, 3H), 3.54(s, 3H), 3.78(s, 3H), 5.19(s, 2H), 5.44(d.d, J=18 & 0.6Hz, 1H), 5.90 (d.d, J=18 & 0.9Hz, 1H), 6.84(s, 1H), 6.86–6.98(m, 1H), 7.09–7.18(m, 2H), 7.31–7.52(m, 8H), 7.71(d.d, J=7.2 & 2.4Hz, 1H) IR(KBr)1608, 1518, 1479, 1365, 1235, 1177, 1118, 1079, 1013cm⁻¹ I-782 ¹H NMR(CDCl₃) δ 1.59(d, J=6.3Hz, 3H), 2.68(s, 3H), 3.13(s, 3H), 3.55(s, 3H), 3.78(s, 3H), 5.19(s, 2H), 5.21–5.30(m, 1H), 6.84(s, 1H), 7.08–7.17(m, 3H), 7.32–7.56(m, 7H), 7.69–7.75(m, 1H) IR(KBr)3543, 3433, 1609, 1518, 1480, 1364, 1235, 1178, 1117, 1078, 1014cm⁻¹ I-783 ¹H NMR(CDCl₃) δ 1.59(d, J=6.0Hz, 3H), 2.01(brs, 1H), 3.47(s, 3H), 3.76(s, 3H), 5.16(s, 2H), 5.15–5.30(m, 1H), 5.72 (s, 1H), 5.91(s, 1H), 6.46(s, 1H), 6.89–7.16(m, 4H), 7.30–7.60(m, 6H), 7.68–7.85(m, 1H) IR(KBr)3467, 1613, 1586, 1517, 1484, 1455, 1421, 1395, 1287, 1238, 1111, 1070, 1010cm⁻¹

TABLE 155 I-784 ¹H NMR(CDCl₃) δ 1.77(s, 3H), 1.81(s, 3H), 3.23(s, 3H), 3.81(s, 6H), 4.64(d, J=6.6Hz, 2H), 5.47–5.54(m, 1H), 6.91(s, 1H), 6.96(s, 1H), 7.06(d, J=8.4Hz, 1H), 7.49(d.d, J=8.4 & 2.1Hz, 1H), 7.58(d, J=2.1Hz, 1H), 7.60–7.74(m, 4H) IR(KBr)2228, 1610, 1490, 1348, 1295, 1266, 1209, 1174, 1112, 1056, 1038, 1000cm⁻¹ I-785 mp 169–170° C. ¹H NMR(CDCl₃) δ 2.07(s, 6H), 3.20(s, 3H), 5.16(s, 2H), 5.71(brs, 1H), 6.97–7.45(m, 14H) IR(KBr)3357, 3023, 2933, 1698, 1516, 1478, 1362, 1260, 1227, 1152, 1132, 962, 869cm⁻¹ I-786 mp 169–170° C. ¹H NMR(CDCl₃) δ 2.13(s, 6H), 3.11(s, 3H), 3.18(s, 3H), 5.18(s, 2H), 7.09–7.47(m, 12H), 7.64(d, J=9.0Hz, 2H) IR(KBr)3434, 3035, 2938, 1516, 1474, 1362, 1290, 1197, 1182, 1174, 1149, 1114, 973, 857, 842cm⁻¹ I-787 mp 156–157° C. ¹H NMR(CDCl₃) δ 2.08(s, 6H), 3.12(s, 3H), 3.21(s, 3H), 5.18(s, 2H), 7.12–7.58(m, 14H) IR(KBr)3494, 3292, 3033, 2934, 1753, 1712, 1517, 1478, 1358, 1294, 1261, 1173, 1151, 967, 870cm⁻¹ I-788 mp 105–106° C. ¹H NMR(CDCl₃) δ 1.75(s, 3H), 1.85(s, 3H), 2.12(s, 6H), 3.18(s, 3H), 3.22(s, 3H), 4.64(d, J=7.0Hz, 2H), 5.52(t, J=6.8Hz, 1H), 7.08(s, 1H), 7.16–7.38(m, 6H), 7.64(d, J=8.8Hz, 2H) IR(KBr)3434, 2934, 1514, 1474, 1362, 1285, 1152, 1113, 971, 916, 861, 845cm⁻¹ I-789 mp 148–149° C. ¹H NMR(CDCl₃) δ 2.12(s, 6H), 2.39(s, 3H), 3.10(s, 3H), 3.18(s, 3H), 5.13(s, 2H), 7.10–7.38(m, 11H), 7.64(d, J=8.6Hz, 2H) IR(KBr)3435, 3027, 2931, 1678, 1516, 1475, 1362, 1288, 1182, 1151, 1113, 969, 916, 861cm⁻¹

TABLE 156 I-790 mp 139–140° C. ¹H NMR(CDCl₃) δ 1.76(s, 3H), 1.82(s, 3H), 2.14(s, 6H), 2.46–2.58(m, 2H), 3.14(s, 3H), 3.19(s, 3H), 4.07(d, J=7.0Hz, 2H), 5.16–5.23(m, 1H), 7.05(s, 1H), 7.14–7.41(m, 6H), 7.66(d, J=8.4Hz, 2H) IR(KBr)3433, 2946, 1514, 1467, 1360, 1282, 1180, 1152, 1115, 868cm⁻¹ I-791 mp 123–124° C. ¹H NMR(DMSO-d₆) δ 1.72(s, 3H), 1.77(s, 3H), 2.03(s, 6H), 4.56(d, J=6.6Hz, 2H), 5.50(t, J=6.0Hz, 1H), 6.49(d, J=9.6Hz, 1H), 6.55(s, 1H), 6.83(d, J=8.4Hz, 2H), 6.98(d, J=8.1Hz, 1H), 7.27(s, 2H), 7.48(d, J=5.6Hz, 2H), 8.92(brs, 1H), 9.48(brs, 1H) IR(KBr)3337, 2930, 1612, 1518, 1471, 1285, 1258, 1207, 1123, 999, 834cm⁻¹ I-792 mp 230–231° C. ¹H NMR(DMSO-d₆) δ 2.04(s, 6H), 2.33(s, 3H), 5.09(s, 2H), 6.50(d, J=8.4Hz, 1H), 6.59(s, 1H), 6.85(d, J=8.1Hz, 2H), 7.04(d, J=5.4Hz, 1H), 7.23(d, J=7.5Hz, 2H), 7.29(s, 1H), 7.41(d, J=7.8Hz, 2H), 7.49(d, J=8.7Hz, 2H), 9.05(brs, 1H), 9.50(brs, 1H) IR(KBr)3287, 1609, 1519, 1475, 1298, 1245, 1126, 1006, 841cm⁻¹ I-793 mp 118–119° C. ¹H NMR(DMSO-d₆) δ 1.64(s, 3H), 1.70(s, 3H), 2.03(s, 6H), 2.42–2.50(m, 2H), 3.96(t, J=6.9Hz, 2H), 5.27(t, J=7.2Hz, 2H), 6.49(d, J=8.1Hz, 1H), 6.55(s, 1H), 6.84(d, J=8.4Hz, 2H), 6.96(d, J=8.1Hz, 1H), 7.27(s, 2H), 7.48(d, J=8.7Hz, 2H), 8.89(brs, 1H), 9.48(brs, 1H) IR(KBr)3392, 2928, 1610, 1519, 1466, 1250, 1230, 1205, 1178, 1128, 1031, 834, 808cm⁻¹ I-794 mp 139–140° C. ¹H NMR(DMSO-d₆) δ 1.75(s, 3H), 1.77(s, 3H), 2.50(s, 6H), 3.39(s, 3H), 3.44(s, 3H), 4.69(d, J=6.2Hz, 2H), 5.50(t, J=6.6Hz, 1H), 7.29–7.33(m, 3H), 7.41–7.47(m, 4H), 7.59–7.68(m, 2H) IR(KBr)3433, 2933, 1675, 1516, 1473, 1366, 1358, 1292, 1259, 1182, 1172, 1151, 969, 873cm⁻¹

TABLE 157 I-795 mp 151–152° C. ¹H NMR(DMSO-d₆) δ 2.05(s, 6H), 2.18(s, 3H), 3.36(s, 3h), 3.44(s, 3H), 5.22(s, 2H), 7.08–7.63(m, 13H) IR(KBr)3434, 3023, 2928, 1517, 1477, 1368, 1293, 1261, 1183, 1152, 966, 870cm⁻¹ I-796 mp 159–160° C. ¹H NMR(DMSO-d₆) δ 1.65(s, 3H), 1.70(s, 3H), 2.05(s, 6H), 2.48–2.53(m, 2H), 3.38(s, 3H), 3.44(s, 3H), 4.10(t, J=7.4Hz, 2H), 5.21–5.27(m, 1H), 7.28–7.34(m, 3H), 7.41–7.47(m, 4H), 7.59–7.64(m, 2H) IR(KBr)3434, 2938, 1519, 1478, 1439, 1362, 1295, 1269, 1173, 1152, 1125, 960, 870, 839cm⁻¹ I-797 mp 130–131° C. ¹H NMR(DMSO-d₆) δ 1.72(s, 3H), 1.75(s, 3H), 2.02(s, 6H), 4.59(d, J=6.4Hz, 2H), 5.48(t, J=7.2Hz, 1H), 6.81–7.07 (m, 7H), 7.25(s, 2H), 8.96(brs, 1H), 9.41(brs, 1H) IR(KBr)3392, 1608, 1589, 1518, 1475, 1322, 1258, 1170, 1127, 974, 836, 808cm⁻¹ I-798 mp 143–144° C. ¹H NMR(DMSO-d₆) δ 2.03(s, 6H), 2.32(s, 3H), 5.12(s, 2H), 6.82–7.41(m, 13H), 9.10(brs, 1H), 9.41(brs, 1H) IR(KBr)3344, 1609, 1521, 1427, 1255, 1236, 1205, 1129, 998, 832, 806, 792cm⁻¹ I-799 mp 163–164° C. ¹H NMR(DMSO-d₆) δ 1.87(s, 3H), 1.90(s, 3H), 3.42(s, 3H), 5.15(s, 2H), 6.88–7.03(m, 4H), 7.24–7.58(m, 9H), 7.97(brs, 1H), 9.02(brs, 1H) IR(KBr)3563, 3476, 3001, 2922, 1698, 1527, 1512, 1476, 1359, 1303, 1261, 1237, 1210, 1195, 1167, 1146, 871cm⁻¹ I-800 ¹H NMR(CDCl₃) δ 1.30(d, J=6.6Hz, 6H), 2.58(s, 3H), 2.97(quintet, J=6.6Hz, 1H), 3.54(s, 3H), 3.77(s, 3H), 5.17(s, 2H), 6.87(s, 1H), 7.11(d, J=9.0Hz, 1H), 7.22–7.35(m, 8H), 7.47–7.68(m, 6H), 8.19–8.25(m, 2H) IR(KBr)1737, 1604, 1519, 1482, 1392, 1366, 1267, 1173, 1131, 1084, 1062, 1009cm⁻¹

TABLE 158 I-801 ¹H NMR(CDCl₃) δ 2.56(s, 3H), 3.55(s, 3H), 3.78(s, 3H), 5.17(s, 2H), 5.69(s, 1H), 6.84(s, 1H), 6.91(d.d, J=8.4 & 1.8Hz, 1H), 7.02(d, J=8.4Hz, 1H), 7.04(d, J=1.8Hz, 1H), 7.04–7.14(m, 1H), 7.33–7.47(m, 8H) IR(KBr)3446, 1613, 1585, 1522, 1477, 1396, 1357, 1291, 1243, 1204, 1174, 1076, 1017, 1006cm⁻¹ I-802 foam ¹H NMR(CDCl₃) δ 2.82(s, 3H), 3.22(s, 3H), 3.25(s, 3H), 3.26(s, 3H), 3.55(s, 3H), 3.78(s, 3H), 5.48(s, 2H), 6.85(s, 1H), 7.27(d, J=8.4Hz, 1H), 7.39(d, J=8.7Hz, 2H), 7.40(dd, J=8.4, 2.1Hz, 1H), 7.43(d, J=2.1Hz, 1H), 7.67(d, J=8.7Hz, 2H) IR(Nujol)1608, 1519, 1480, 1462, 1365, 1176, 1151, 1079, 970, 876, 798cm⁻¹ I-803 foam ¹H NMR(CD3OD) δ 3.28(s, 3H), 3.68(s, 3H), 5.17(s, 2H), 6.43(s, 1H), 6.81(dd, J=8.4, 2.1Hz, 1H), 6.85(d, J=8.7Hz, 2H), 6.89(d, J=2.1Hz, 1H), 7.03(d, J=8.4Hz, 1H), 7.46(d, J=8.7Hz, 2H) IR(Nujol)3342, 1611, 1592, 1523, 1488, 1460, 1251, 1225, 1114, 1072, 1012, 941, 826, 756cm⁻¹ I-804 mp 150–152° C. ¹H NMR(DMSO-d₆) δ 3.31(s, 3H), 3.64(s, 3H), 5.00(s, 2H), 6.39(s, 1H), 6.66(dd, J=8.4, 2.1Hz, 1H), 6.79(d, J=2.1Hz, 1H), 6.84(d, J=8.7Hz, 2H), 6.98(d, J=8.4Hz, 1H), 7.44(d, J=8.7Hz, 2H) IR(Nujol)3459, 3291, 1612, 1594, 1522, 1489, 1458, 1257, 1226, 1101, 1073, 1011, 960, 823cm⁻¹ I-805 mp 190–192° C. ¹H NMR(DMSO-d₆) δ 2.88(s, 3H), 3.41(s, 3H), 3.45(s, 3H), 3.52(s, 3H), 3.79(s, 3H), 5.43(s, 2H), 7.08(s, 1H), 7.16(s, 1H), 7.32–7.36(m, 2H), 7.46(d, J=8.4Hz, 1H), 7.49(d, J=8.7Hz, 2H), 7.53–7.64(m, 3H), 7.74(d, J=8.7Hz, 2H), 7.88–7.91 (m, 2H) IR(Nujol)1604, 1519, 1481, 1462, 1367, 1175, 1081, 1009, 878, 841, 816, 801cm⁻¹

TABLE 159 I-806 foam ¹H NMR(CDCl₃) δ 3.45(s, 3H), 3.74(s, 3H), 5.31(s, 2H), 6.94(s, 1H), 6.45(s, 1H), 6.64(s, 1H), 6.93(d, J=8.7Hz, 2H), 6.98(dd, J=8.4, 2.1Hz, 1H), 7.09(d, J=8.4Hz, 1H), 7.11(d, J=2.1Hz, 1H), 7.46–7.50(m, 3H), 7.53(d, J=8.7Hz, 2H), 7.78–7.82(m, 2H) IR(Nujol)3367, 1612, 1592, 1523, 1489, 1455, 1253, 1226, 1115, 1073, 1013, 942, 816, 767cm⁻¹ I-807 foam ¹H NMR(CDCl₃) δ 2.76(s, 3H), 3.21(s, 3H), 3.30(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 5.38(s, 2H), 6.84(s, 1H), 7.21(d, J=8.4Hz, 1H), 7.38(d, J=8.7Hz, 2H), 7.38(dd, J=8.4, 2.1Hz, 1H), 7.45(d, J=2.1Hz, 1H), 7.67(d, J=8.7Hz, 2H), 8.80(s, 1H) IR(Nujol)1608, 1519, 1480, 1463, 1365, 1177, 1151, 1079, 971, 876, 798cm⁻¹ I-808 mp 193–195° C. ¹H NMR(CDCl₃) δ 2.64(s, 3H), 2.74(s, 3H), 3.21(s, 3H), 3.30(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 5.28(s, 2H), 6.84(s, 1H), 7.21(d, J=8.4Hz, 1H), 7.38(d, J=8.7Hz, 2H), 7.38(dd, J=8.4, 2.1Hz, 1H), 7.44(d, J=2.1Hz, 1H), 7.68(d, J=8.7Hz, 2H) IR(Nujol)1606, 1591, 1522, 1480, 1463, 1359, 1174, 1152, 1079, 1012, 946, 877, 834, 796cm⁻¹ I-809 foam ¹H NMR(CDCl₃) δ 1.42(t, J=7.5Hz, 3H), 2.73(s, 3H), 2.96(q, J=7.5Hz, 2H), 3.21(s, 3H), 3.31(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 5.28(s, 2H), 6.84(s, 1H), 7.21(d, J=8.4Hz, 1H), 7.38(d, J=8.7Hz, 2H), 7.38(dd, J=8.4, 2.1Hz, 1H), 7.44 (d, J=2.1Hz, 1H), 7.68(d, J=8.7Hz, 2H) IR(KBr)3434, 1609, 1579, 1519, 1481, 1365, 1177, 1151, 1080, 970, 876, 797cm⁻¹

TABLE 160 I-810 foam ¹H NMR(CDCl₃) δ 2.71(s, 3H), 3.21(s, 3H), 3.35(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 5.38(s, 2H), 6.84(s, 1H), 7.25(d, J=8.4Hz, 1H), 7.38(d, J=8.7Hz, 2H), 7.40(dd, J=8.4, 2.1Hz, 1H), 7.46(d, J=2.1Hz, 1H), 7.54–7.64(m, 3H), 7.68(d, J=8.7Hz, 2H), 8.12–8.16(m, 2H) IR(KBr) 3433, 1609, 1561, 1519, 1480, 1365, 1177, 1151, 1081, 971, 876, 798cm⁻¹ I-811 foam ¹H NMR(CDCl₃) δ 2.51(s, 3H), 2.54(s, 3H), 2.63(s, 3H), 2.72(s, 3H), 3.16(s, 3H), 3.21(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 5.27(s, 2H), 6.84(s, 1H), 7.27(d, J=8.4Hz, 1H), 7.36(dd, J=8.4, 2.1Hz, 1H), 7.38(d, J=8.7Hz, 2H), 7.41(d, J=2.1Hz, 1H), 7.68(d, J=8.7Hz, 2H) IR(KBr) 3435, 1614, 1519, 1480, 1364, 1177, 1151, 1080, 972, 876, 798cm⁻¹ I-812 foam ¹H NMR(CDCl₃) δ 2.74(s, 6H), 3.17(s, 3H), 3.21(s, 3H), 3.55(s, 3H), 3.78(s, 3H), 5.35(s, 2H), 6.84(s, 1H), 7.28(d, J=8.4Hz, 1H), 7.36(dd, J=8.4, 2.1Hz, 1H), 7.38(d, J=8.7Hz, 2H), 7.41(d, J=2.1Hz, 1H), 7.68(d, J=8.7Hz, 2H), 8.41(d, J=2.4Hz, 1H), 8.50(d, J=2.4Hz, 1H) IR(KBr) 3433, 1609, 1519, 1481, 1364, 1177, 1151, 1080, 971, 876, 798cm⁻¹ I-813 foam ¹H NMR(DMSO-d₆) δ 2.47(s, 6H), 2.55(s, 3H), 3.30(s, 3H), 3.64(s, 3H), 5.16(s, 2H), 6.39(s, 1H), 6.66(dd, J=8.4, 2.1Hz, 1H), 6.76(d, J=2.1Hz, 1H), 6.84(d, J=8.7Hz, 2H), 7.03(d, J=8.4Hz, 1H), 7.44(d, J=8.7Hz, 2H), IR(KBr) 3399, 3165, 1611, 1521, 1488, 1406, 1362, 1213, 1114, 1069, 1014, 818, 759cm⁻¹

TABLE 161 I-814 mp 240–241° C. ¹H NMR(DMSO-d₆) δ 2.66(s, 3H), 3.30(s, 3H), 3.64(s, 3H), 5.26(s, 2H), 6.39(s, 1H), 6.66(dd, J=8.4, 2.1Hz, 1H), 6.77 (d, J=2.1Hz, 1H), 6.84(d, J=8.7Hz, 2H), 7.02(d, J=8.4Hz, 1H), 7.44(d, J=8.7Hz, 2H), 8.48(d, J=2.7Hz, 1H), 8.53(d, J=2.7Hz, 1H) IR(Nujol) 3513, 3491, 3070, 1610, 1581, 1523, 1488, 1459, 1408, 1275, 1236, 1216, 1111, 1065, 1040, 821, 785cm⁻¹ I-815 mp 288–290° C.(decomp.) ¹H NMR(DMSO-d₆) δ 2.89(s, 3H), 3.41(s, 3H), 3.45(s, 3H), 3.52(s, 3H), 3.79(s, 3H), 4.95(s, 2H), 5.65(s, 1H), 7.08(s, 1H), 7.26(d, J=8.4Hz, 1H), 7.33(dd, J=8.4, 2.1Hz, 1H), 7.38(d, J=2.1Hz, 1H), 7.49(d, J=8.7Hz, 2H), 7.74(d, J=8.7Hz, 2H), IR(Nujol) 3120, 1712, 1671, 1604, 1516, 1480, 1462, 1364, 1172, 1078, 1015, 970, 874, 841, 796cm⁻¹ I-816 mp 204–206° C. ¹H NMR(DMSO-d₆) δ 2.87(s, 3H), 3.45(s, 3H), 3.46(s, 3H), 3.52(s, 3H), 3.78(s, 3H), 5.40(s, 2H), 7.08(s, 1H), 7.32(dd, J=8.4, 2.1Hz, 1H), 7.33(d, J=8.4Hz, 1H), 7.39(d, J=2.1Hz, 1H), 7.48(d, J=8.7Hz, 2H), 7.71(dd, J=5.1, 1.2Hz, 1H), 7.74(d, J=8.7Hz, 2H), 8.88(d, J=5.1Hz, 1H), 9.21(d, J=1.2Hz, 1H) IR(Nujol) 1608, 1586, 1557, 1521, 1480, 1464, 1360, 1352, 1176, 1156, 1078, 884, 835, 818, 799cm⁻¹ I-817 foam ¹H NMR(CDCl₃) δ 2.20(s, 3H), 3.45(s, 3H), 3.75(s, 3H), 5.15(s, 2H), 6.45(s, 1H), 6.92(d, J=8.7Hz, 2H), 6.94(dd, J=1.8, 84Hz, 1H), 6.98(d, J=8.4Hz, 1H), 7.09(d, J=1.8Hz, 1H), 7.18(m, 1H), 7.37(t, J=7.2Hz, 1H), 7.53(d, J=8.7Hz, 2H), 7.55(m, 2H)

TABLE 162 I-818 m.p 163–166° C. ¹H NMR(CDCl₃) δ 1.53(s, 9H), 2.67(s, 3H), 3.11(s, 3H), 3.21(s, 3H), 3.56(s, 3H), 3.77(s, 3H), 5.12(s, 2H), 6.52(s, 1H), 6.84(s, 1H), 7.13(d, J=8.4Hz, 1H), 7.33(dd, J=2.1, 8.4Hz, 1H), 7.38(d, J=8.7Hz, 2H), 7.39(m, 5H), 7.74(d, J=8.7Hz, 2H) IR(KBr) 1692, 1614, 1520, 1480, 1390, 1367, 1231, 1175, 1152, 1078, 876, 799cm⁻¹ I-819 m.p 172° C. ¹H NMR(CDCl₃) δ 2.77(s, 3H), 3.05(s, 3H), 3.16(s, 3H), 3.22(s, 3H), 3.36(s, 3H), 3.78(s, 3H), 5.16(s, 2H), 6.46(s, 1H), 6.85(s, 1H), 7.14(d, J=8.4Hz, 1H), 7.25(d, J=8.7Hz, 2H), 7.35(dd, J=2.1, 8.4Hz, 1H), 7.39(d, J=8.7Hz, 2H), 7.40(d, J=2.1, 1H), 7.47(d, J=8.4Hz, 2H), 7.67(d, J=8.7Hz, 2H) IR(KBr) 1608, 1519, 1480, 1361, 1175, 1154, 1079, 972, 876, 801cm⁻¹ I-820 mp 180–182° C. ¹H NMR(CDCl₃) δ 2.69(s, 3H), 3.14(s, 3H), 3.21(s, 3H), 3.53(s, 3H), 3.71(d, J=0.9Hz, 3H), 5.20(s, 2H), 6.93(d, J=8.4Hz, 1H), 7.34–7.49(m, 9H), 7.59(dd, J=9.0, 1.2Hz, 2H) IR(KBr) 1518, 1469, 1357, 1179, 1151, 1038, 871, 821cm⁻¹ I-821 mp 183–185° C. ¹H NMR(CDCl₃) δ 3.41(s, 3H), 3.66(d, J=0.9Hz, 3H), 4.91(s, 1H), 5.17(s, 2H), 5.62(s, 1H), 5.70(s, 1H), 6.92–6.96(m, 2H), 6.97(dd, J=8.4, 2.0Hz, 1H), 7.04(d, J=8.4Hz, 1H), 7.10(d, J=2.0Hz, 1H), 7.36–7.48(m, 7H) IR(KBr) 3541, 3398, 1588, 1523, 1461, 1410, 1320, 1261, 1217, 1037, 836, 747cm⁻¹ I-822 mp 108–110° C. ¹H NMR(CDCl₃) δ 2.69(s, 3H), 3.13(s, 3H), 3.45(s, 3H), 3.53(s, 3H), 3.77(s, 3H), 4.66(s, 2H), 4.76(s, 2H), 5.19(s, 2H), 6.86(s, 1H), 7.71(d, J=8.4Hz, 1H), 7.33–7.48(m, 9H), 7.62(d, J=8.4Hz, 2H) IR(KBr) 1482, 1390, 1307, 1276, 1177, 1083, 1053, 1013, 807cm⁻¹

TABLE 163 I-823 mp 192–194° C. ¹H NMR(CDCl₃) δ 1.70(br s, 1H), 2.69(s, 3H), 3.13(s, 3H), 3.53(s, 3H), 3.77(s, 3H), 4.78(s, 2H), 5.19(s, 2H), 6.87(s, 1H), 7.15(d, J=8.4Hz, 1H), 7.35(dd, J=8.4, 2.3Hz, 1H), 7.37–7.49(m, 8H), 7.63(d, J=7.8Hz, 2H) IR(KBr) 3554, 3434, 1522, 1481, 1389, 1364, 1277, 1234, 1174, 1085, 1012, 807cm⁻¹ I-824 mp 135–137° C. ¹H NMR(CDCl₃) δ 3.19(s, 3H), 3.60(s, 3H), 3.71(s, 3H), 4.96(s, 1H), 5.18(s, 2H), 5.78(s, 1H), 6.73(s, 1H), 6.88(dd, J=8.3, 2.1Hz, 1H), 7.02(d, J=2.1Hz, 1H), 7.08(d, J=8.3Hz, 1H), 7.34(d, J=8.6Hz, 2H), 7.41–7.47(m, 5H), 7.63(d, J=8.6Hz, 2H) IR(KBr) 3479, 1473, 1347, 1149, 1010, 869, 803, 784, 747cm⁻¹ I-825 mp 149–151° C. ¹H NMR(CDCl₃) δ 2.68(s, 3H), 3.13(s, 3H), 3.20(s, 3H), 3.69(s, 3H), 3.71(s, 3H), 5.20(s, 2H), 7.18(d, J=8.7Hz, 1H), 7.21(s, 1H), 7.35–7.50(m, 9H), 7.63(d, J=8.1Hz, 2H) IR(KBr) 1519, 1469, 1353, 1173, 1149, 1050, 966, 873, 849, 810cm⁻¹ I-826 mp 82–85° C. ¹H NMR(CDCl₃) δ 1.78(s, 3H), 1.82(s, 3H), 2.70(s, 3H), 3.20(s, 3H), 3.25(s, 3H), 3.69(s, 3H), 3.70(s, 3H), 4.65(d, J=6.9Hz, 2H), 5.51(t, J=6.9Hz, 1H), 7.11(d, J=8.8Hz, 1H), 7.21(s, 1H), 7.37(d, J=8.9Hz, 2H), 7.38(dd, J=8.8, 2.2Hz, 1H), 7.42(d, J=2.2Hz, 1H), 7.63(d, J=8.9Hz, 2H) IR(KBr) 1516, 1468, 1363, 1180, 1151, 1045, 967, 846, 788cm⁻¹ I-827 amorphous ¹H NMR(CDCl₃) δ 1.77(s, 3H), 1.83(s, 3H), 3.58(s, 3H), 3.70(s, 3H), 4.64(d, J=6.7Hz, 2H), 4.97(s, 1H), 5.04(s, 1H), 5.53(t, J=6.7Hz, 1H), 5.81(s, 1H), 6.73(s, 1H), 6.87(dd, J=8.1, 2.0Hz, 1H), 6.88(d, J=8.7Hz, 2H), 6.99(d, J=2.0Hz, 1H), 7.00(d, J=8.1Hz, 1H), 7.47(d, J=8.7Hz, 2H) IR(CHCl₃) 3595, 3536, 1613, 1584, 1521, 1474, 1406, 1356, 1266, 1094, 1062, 1014, 973, 835cm⁻¹

TABLE 164 I-828 mp 161–162° C. ¹H NMR(CDCl₃) δ 3.58(s, 3H), 3.71(s, 3H), 4.85(s, 1H), 4.93(s, 1H), 5.18(s, 2H), 5.78(s, 1H), 6.73(s, 1H), 6.87–6.92(m, 3H), 7.02(d, J=1.8Hz, 1H), 7.07(d, J=8.1Hz, 1H), 7.37–7.51(m, 7H) IR(KBr) 3510, 3442, 3326, 1523, 1485, 1453, 1395, 1239, 1061, 1003, 972, 836, 753cm⁻¹ I-829 mp 85–87° C. ¹H NMR(CDCl₃) δ 1.69(s, 3H), 1.75(s, 3H), 2.57(q, J=6.9Hz, 2H), 2.70(s, 3H), 3.20(s, 3H), 3.24(s, 3H), 3.69(s, 3H), 3.69(s, 3H), 4.09(t, J=6.9Hz, 2H), 5.22(t, J=6.9Hz, 1H), 7.10(d, J=8.4Hz, 1H), 7.21(s, 1H), 7.37–7.44(m, 9H), 7.63(d, J=8.4Hz, 2H) IR(KBr) 1519, 1468, 1362, 1179, 1150, 1046, 967, 865, 847cm⁻¹ I-830 mp 160–162° C. ¹H NMR(CDCl₃) δ 2.38(s, 3H), 2.68(s, 3H), 3.12(s, 3H), 3.20(s, 3H), 3.69(s, 3H), 3.70(s, 3H), 5.15(s, 2H), 7.16–7.25(m, 4H), 7.34–7.44(m, 6H), 7.63(d, J=8.1Hz, 2H) IR(KBr) 1519, 1469, 1365, 1173, 1149, 1049, 965, 873, 849, 808cm⁻¹ I-831 amorphous ¹H NMR(CDCl₃) δ 1.69(s, 3H), 1.76(s, 3H), 2.55(q, J=6.9Hz, 1H), 3.58(s, 3H), 3.69(s, 3H), 4.08(t, J=6.9Hz, 2H), 4.98(s, 1H), 5.18(s, 1H), 5.23(t, J=6.9Hz, 1H), 5.80(s, 1H), 6.72(s, 1H), 6.86–6.89(m, 3H), 6.97–7.00(m, 3H), 7.47(d, J=8.4Hz, 2H) IR(KBr) 3595, 3538, 1521, 1471, 1265, 1173, 1095, 1063, 1015, 835cm⁻¹ I-832 mp 200–201° C. ¹H NMR(CDCl₃) δ 2.40(s, 3H), 3.58(s, 3H), 3.70(s, 3H), 4.80(s, 1H), 4.92(s, 1H), 5.13(s, 2H), 5.77(s, 1H), 6.73(s, 1H), 6.88(dd, J=8.1, 2.0Hz, 1H), 6.89(d, J=8.4Hz, 2H), 7.01(d, J=1.8Hz, 1H), 7.07(d, J=8.4Hz, 1H), 7.24(d, J=7.8Hz, 2H), 7.35(d, J=7.8Hz, 2H), 7.48(d, J=8.4Hz, 2H), IR(KBr) 3419, 1610, 1523, 1485, 1393, 1243, 1065, 1004, 972, 833, 795cm⁻¹

TABLE 165 I-833 mp 141–142° C. ¹H NMR(CDCl₃) δ 2.03(s, 3H), 2.11(s, 3H), 2.54(s, 3H), 3.15(s, 3H), 3.21(s, 3H), 5.20(s, 2H), 7.12–7.26(m, 5H), 7.38–7.50 (m, 8H) IR(KBr) 3435, 3033, 2938, 1518, 1470, 1364, 1178, 1149, 1109, 970, 871, 839cm⁻¹ I-834 mp 188–189° C. ¹H NMR(CDCl₃) δ 3.49(s, 3H), 3.72(s, 3H), 5.15(s, 2H), 5.68(brs, 1H), 5.84(brs, 1H), 6.42–6.56(m, 3H), 6.98–7.08(m, 3H), 7.23–7.31(m, 3H), 7.23–7.31(m, 2H), 7.38–7.45(m, 4H) IR(KBr) 3420, 3328, 1627, 1584, 1523, 1489, 1460, 1412, 1316, 1288, 1249, 1172, 1128, 1115, 1068, 1000, 849, 812, 746cm⁻¹ I-835 mp 180–181° C. ¹H NMR(CDCl₃) δ 3.51(s, 3H), 3.75(s, 3H), 5.17(s, 2H), 5.70(brs, 1H), 5.77(brs, 1H), 6.45(s, 1H), 6.95–7.10(m, 4H), 7.27–7.46(m, 8H), 7.96(brs, 1H)) IR(KBr) 3422, 3358, 1706, 1602, 1489, 1454, 1410, 1289, 1253, 1203, 1180, 1125, 1101, 1071, 1015cm⁻¹ I-836 mp 148–149° C. ¹H NMR(DMSO-d₆) δ 1.77(s, 3H), 1.80(s, 3H), 2.54(s, 6H), 3.35(s, 3H), 3.42(s, 3H), 3.48(s, 3H), 4.73(d, J=4.5Hz, 2H), 5.50–5.53(m, 1H), 7.30–7.54(m, 8H) IR(KBr) 3495, 3293, 1754, 1712, 1516, 1359, 1359, 1243, 1175, 1147, 971, 866, 845cm⁻¹ I-837 mp 136–138° C. ¹H NMR(DMSO-d₆) δ 2.32(s, 3H), 2.50(s, 6H), 3.31(s, 3H), 3.35(s, 3H), 3.44(s, 3H), 5.23(s, 2H), 7.21–7.47(m, 12H) IR(KBr) 3495, 3292, 3028, 2934, 1754, 1710, 1516, 1357, 1176, 1147, 972, 868, 842cm⁻¹

TABLE 166 I-838 mp 195–196° C. ¹H NMR(CDCl₃) δ 1.44(t, J=7.2Hz, 3H), 3.46(s, 3H), 3.69(s, 3H), 3.86(s, 6H), 4.44(q, J=7.0Hz, 2H), 5.15(s, 2H), 5.66(brs, 1H), 5.72(brs, 1H), 6.27(s, 1H), 7.01(s, 2H), 7.13(s, 1H), 7.38–7.46(m, 7H) IR(KBr) 3485, 2937, 1713, 1580, 1464, 1455, 1407, 1324, 1243, 1123, 1102, 1069, 1014, 763cm⁻¹ I-839 mp 150–151° C. ¹H NMR(DMSO-d₆) δ 1.72(s, 3H), 1.76(s, 3H), 1.88(s, 3H), 1.90(s, 3H), 4.55(d, J=5.8Hz, 2H), 5.44–5.50(m, 1H), 6.80–6.97(m, 8H), 7.81(brs, 1H), 8.85(brs, 1H), 9.38(brs, 1H) IR(KBr) 3495, 3293, 1753, 1711, 1429, 1390, 1360, 1242, 1217, 1178, 1143, 781cm⁻¹ I-840 mp 149–150° C. ¹H NMR(DMSO-d₆) δ 1.71(s, 3H), 1.75(s, 3H), 2.00(s, 6H), 2.59(s, 3H), 4.57(d, J=6.4Hz, 2H), 5.42–5.47(m, 1H), 6.84–7.13(m, 8H), 9.13(brs, 1H), 9.50(brs, 1H) IR(KBr) 3451, 2933, 1612, 1587, 1518, 1472, 1348, 1259, 1211, 1171, 1121, 1087, 969, 872, 835, 813cm⁻¹ I-841 mp 203–204° C. ¹H NMR(DMSO-d₆) δ 1.87(s, 3H), 1.89(s, 3H), 2.31(s, 3H), 5.09(s, 2H), 6.80–7.00(m, 8H), 7.20(d, J=7.8Hz, 2H), 7.39 (d, J=7.8Hz, 2H), 7.81(brs, 1H), 8.97(brs, 1H), 9.38(brs, 1H) IR(KBr) 3491, 3398, 2921, 1611, 1516, 1476, 1259, 1183, 1155, 996, 794cm⁻¹ I-842 mp 128–129° C. ¹H NMR(DMSO-d₆) δ 2.01(s, 6H), 2.34(s, 3H), 2.63(s, 3H), 5.12(s, 2H), 6.85–7.13(m, 8H), 7.18(d, J=7.6Hz, 2H), 7.36 (d, J=7.6Hz, 2H), 9.15(brs, 1H), 9.55(brs, 1H) IR(KBr) 3432, 3305, 1735, 1607, 1523, 1482, 1398, 1360, 1294, 1284, 1179, 1080, 816cm⁻¹

TABLE 167 I-843 mp 203–204° C. ¹H NMR(CDCl₃) δ 2.66(s, 3H), 3.13(s, 3H), 3.59(s, 3H), 3.76(s, 3H), 5.19(s, 2H), 6.85(s, 1H), 7.13–7.69(m, 11H), 8.07 (brs, 1H) IR(KBr) 3432, 3305, 1735, 1607, 1523, 1482, 1398, 1360, 1294, 1284, 1179, 1080, 816cm⁻¹ I-844 mp 109–110° C. ¹H NMR(DMSO-d₆) δ 1.36(t, J=7.2Hz, 3H), 2.82(s, 3H), 3.24(s, 3H), 3.47(s, 3H), 3.66(s, 3H), 3.79(s, 6H), 4.38(q, J=7.0Hz, 2H), 5.26(s, 2H), 6.78(s, 1H), 7.32–7.52(m, 10H) IR(KBr) 3432, 2940, 1716, 1579, 1465, 1407, 1366, 1322, 1240, 1179, 1123, 1078, 815, 796cm⁻¹ I-845 mp 113–115° C. ¹H NMR(CDCl₃) δ 2.25(s, 3H), 2.27(s, 3H), 3.20(s, 3H), 5.20(s, 2H), 7.03–7.15(m, 5H), 7.33–7.51(m, 9H) IR(CHCl₃) 2925, 1618, 1580, 1521, 1455, 1373, 1314, 1299, 1268, 1174, 1149, 1126, 1018, 970, 874cm⁻¹ I-846 mp 155–157° C. ¹H NMR(CDCl₃) δ 2.26(s, 6H), 4.69(s, 1H), 5.19(s, 2H), 6.87–6.90(m, 2H), 7.03–7.15(m, 5H), 7.22–7.50(m, 7H) IR(CHCl₃) 3596, 2952, 2924, 1612, 1582, 1523, 1490, 1455, 1425, 1383, 1259, 1171, 1125, 1012, 956, 877cm⁻¹ I-847 mp 81–84° C. ¹H NMR(CDCl₃) δ 1.07–1.14(m, 6H), 2.55–2.66(m, 4H), 4.73(s, 1H), 5.16(s, 2H), 5.70(s, 1H), 6.82–6.91(m, 3H), 6.92–6.99 (m, 2H), 7.10–7.12(d, J=4.2Hz, 2H), 7.22–7.25(m, 2H), 7.38–7.49(m, 5H) IR(CHCl₃) 3596, 3542, 2968, 2932, 2872, 1731, 1611, 1588, 1520, 1489, 1455, 1380, 1327, 1289, 1256, 1171, 1126, 1011, 903, 878, 836cm⁻¹ I-848 mp 125–127° C. ¹H NMR(CDCl₃) δ 1.77(s, 3H), 1.82(s, 3H), 2.26(s, 3H), 2.28(s, 3H), 3.20(s, 3H), 4.63–4.65(d, J=6.9Hz, 2H), 5.56(m, 1H), 7.02–7.13(m, 5H), 7.31–7.43(m, 4H) IR(CHCl₃) 2924, 1619, 1578, 1488, 1373, 1298, 1266, 1174, 1149, 1125, 970, 874cm⁻¹

TABLE 168 I-849 mp 141–143° C. ¹H NMR(CDCl₃) δ 1.07–1.14(m, 6H), 2.53–2.65(m, 4H), 3.12(s, 3H), 3.20(s, 3H), 5.18(s, 2H), 7.10–7.14(m, 3H), 7.24–7.27 (m, 2H), 7.33–7.50(m, 9H) IR(CHCl₃) 2969, 2934, 1614, 1517, 1487, 1371, 1331, 1289, 1263, 1173, 1149, 1111, 970, 938, 872cm⁻¹ I-850 mp 90–91° C. ¹H NMR(CDCl₃) δ 2.13(s, 3H), 2.29(s, 3H), 2.35(s, 3H), 3.16(s, 3H), 5.21(s, 2H), 6.87–6.90(m, 2H), 7.09–7.49(m, 11H) IR(CHCl₃) 3596, 1731, 1613, 1520, 1478, 1362, 1261, 1173, 1119, 1086, 1025, 972, 953, 874cm⁻¹ I-851 mp 94–96° C. ¹H NMR(CDCl₃) δ 1.76–1.77(d, J=0.3Hz, 3H), 1.81–1.82(d, J=0.9Hz, 3H), 2.26(s, 3H), 2.27(s, 3H), 4.62–4.64(d, J=6.9Hz, 2H), 4.71(s, 1H), 5.56(m, 1H), 6.87–6.91(m, 2H), 7.00–7.13(m, 5H), 7.23–7.27(m, 2H) IR(CHCl₃) 3596, 2923, 1675, 1613, 1579, 1523, 1490, 1386, 1297, 1171, 1124, 990, 956, 877, 836cm⁻¹ I-852 mp 106–108° C. ¹H NMR(CDCl₃) δ 2.63(s, 3H), 3.52(s, 3H), 3.77(s, 3H), 5.24(s, 2H), 6.84(s, 1H), 6.84(s, 1H), 7.12–7.20(m, 3H), 7.35–7.50 (m, 7H), 7.56–7.64(m, 2H) IR(KBr) 2935, 1604, 1523, 1483, 1373, 1232, 1086, 1011, 945, 847, 728, 605, 523, 506cm⁻¹ I-853 mp 136–138° C. ¹H NMR(CDCl₃) δ 1.77(s, 3H), 1.81(s, 3H), 2.67(s, 3H), 3.53(s, 3H), 3.78(s, 3H), 4.67(d, J=6.9Hz, 2H), 5.47–5.53(m, 1H), 6.84(s, 1H), 7.10–7.19(m, 3H), 7.31(d, J=2.1Hz, 1H), 7.38(dd, J=2.1, 8.1Hz, 1H), 7.57–7.64(m, 2H) IR(KBr) 2936, 1604, 1523, 1484, 1435, 1373, 1225, 1086, 1011, 943, 848, 783, 606, 508cm⁻¹

TABLE 169 I-854 mp 128–130° C. ¹H NMR(CDCl₃) δ 1.74(s, 3H), 1.81(s, 3H), 2.62(s, 3H), 3.52(s, 3H), 3.79(s, 3H), 4.63–4.67(m, 2H), 5.45–5.53(m, 1H), 6.86(s, 1H), 7.01(dd, J=2.1Hz, 8.4Hz, 1H), 7.10(d, J=1.8Hz, 1H), 7.13–7.20(m, 2H), 7.29(d, J=8.4Hz, 1H), 7.59–7.64 (m, 2H) IR(KBr) 2940, 1600, 1518, 1484, 1418, 1366, 1232, 1080, 984, 893, 838, 812, 621, 524cm⁻¹ I-855 mp 141–143° C. ¹H NMR(CDCl₃) δ 1.76(s, 3H), 1.82(s, 3H), 2.61(s, 3H), 3.53(s, 3H), 3.77(s, 3H), 4.62(d, J=6.9Hz, 2H), 5.47–5.53(m, 1H), 5.70(s, 1H), 6.83(s, 1H), 6.91(dd, J=2.1, 8.1Hz, 1H), 6.96(d, J=8.1Hz, 1H), 7.02(d, J=2.1Hz, 1H), 7.10–7.19(m, 2H), 7.59–7.64(m, 2H) IR(KBr) 3531, 2931, 1604, 1520, 1484, 1372, 1233, 1175, 1083, 1011, 814, 800, 781, 727, 526cm⁻¹ I-856 mp 217–220° C. ¹H NMR(CDCl₃) δ 2.75(s, 3H), 3.51(s, 3H), 3.78(s, 3H), 5.78(s, 1H), 6.85(s, 1H), 7.03(dd, J=1.8, 8.4Hz, 1H), 7.11–7.20 (m, 3H), 7.32(d, J=8.4Hz, 1H), 7.58–7.63(m, 2H) IR(KBr) 3434, 2941, 1611, 1487, 1423, 1363, 1209, 1076, 891, 818, 621, 573, 513cm⁻¹ I-857 mp 183–185° C. ¹H NMR(CDCl₃) δ 1.92(s, 3H), 3.20(s, 3H), 3.53(s, 3H), 3.78(s, 3H), 3.93(s, 3H), 4.31(s, 4H), 6.79–6.83(m, 2H), 6.90–6.94 (m, 2H), 7.16–7.41(m, 12H), 7.66–7.71(m, 2H), IR(KBr) 3030, 2936, 1604, 1517, 1482, 1362, 1232, 1232, 1180, 1120, 1082, 877, 799, 701, 526cm⁻¹ I-858 mp 192–194° C. ¹H NMR(CDCl₃) δ 2.57(s, 3H), 3.21(s, 3H), 3.56(s, 3H), 3.77(s, 3H), 3.87(s, 3H), 6.77–6.89(m, 4H), 7.34–7.40(m, 2H), 7.67–7.72(m, 2H) IR(KBr) 3451, 3368, 2937, 1622, 1524, 1481, 1359, 1174, 1149, 1086, 962, 869, 802, 525cm⁻¹

TABLE 170 I-859 mp 210–212° C. ¹H NMR(CDCl₃) δ 1.92(s, 3H), 2.23(s, 3H), 3.46(s, 3H), 3.74(s, 3H), 3.89(s, 3H), 5.24(s, 1H), 5.80(s, 1H), 5.94(s, 1H), 6.46(s, 1H), 6.90–6.96(m, 1H), 7.01(d, J=1.8Hz, 1H), 7.08(dd, J=1.8, 8.1Hz, 1H), 7.50–7.55(m, 2H), 7.76(s, 1H), 8.52 (d, J=8.1Hz, 1H), IR(KBr) 3420, 2938, 1636, 1610, 1526, 1496, 1398, 1225, 1164, 1073, 1026, 831cm⁻¹ I-860 mp 183–185° C. ¹H NMR(DMSO-d₆) δ 2.43(s, 6H), 2.45(s, 6H), 5.13(s, 2H), 6.76–6.82(m, 4H), 6.91(dd, J=2.1, 8.4Hz, 1H), 7.01(d, J=8.4Hz, 1H), 7.09(d, J=2.1Hz, 1H), 7.31–7.43(m, 5H), 7.48–7.53(m, 2H), 9.02(br s, 1H), 9.32(br s, 1H) IR(KBr) 3600–2800(br), 1609, 1581, 1521, 1493, 1455, 1437, 1384, 1321, 1275, 1215, 1193, 1142, 1007cm⁻¹ I-861 mp 172–174° C. ¹H NMR(CDCl₃) δ 2.50(s, 6H), 2.53(s, 6H), 3.11(s, 3H), 3.19(s, 3H), 5.18(s, 2H), 6.89(s, 1H), 6.93(s, 1H), 7.12(d, J=8.4Hz, 1H), 7.30–7.54(m, 8H), 7.66–7.71(m, 2H), 7.73(d, J=2.1Hz, 1H) IR(KBr) 3600–2800(br), 1613, 1518, 1491, 1455, 1361, 1348, 1276, 1178, 1159, 1109, 970cm⁻¹ I-862 mp 173–175° C. ¹H NMR(CDCl₃) δ 1.77(s, 3H), 1.82(s, 3H), 2.51(s, 6H), 2.53(s, 6H), 3.19(s, 3H), 3.22(s, 3H), 4.63(d, J=7.2Hz, 2H), 5.49–5.53(m, 1H), 6.89(s, 1H), 6.93(s, 1H), 7.05(d, J=9.0Hz, 1H), 7.26–7.35(m, 2H), 7.51(dd, J=1.8, 8.1Hz, 1H), 7.67–7.70 (m, 3H) IR(KBr) 3600–2800(br), 1519, 1491, 1363, 1331, 1291, 1257, 1175, 1147, 1105, 1013, 980, 966cm⁻¹ I-863 mp 150–152° C. ¹H NMR(DMSO-d₆) δ 1.72(s, 3H), 1.76(s, 3H), 2.43(s, 6H), 2.45(s, 6H), 4.55(d, J=6.6Hz, 2H), 5.47–5.51(m, 1H), 6.78–6.83(m, 4H), 6.90–7.06(m, 3H), 7.38–7.42(m, 2H), 8.87(br s, 1H), 9.39(br s, 1H) IR(KBr) 3600–2800(br), 1610, 1585, 1522, 1495, 1476, 1448, 1385, 1292, 1275, 1199, 1171, 1136, 985, 948cm⁻¹

TABLE 171 I-864 mp 175–177° C. ¹H NMR(DMSO-d₆) δ 2.44(s, 12H), 5.13(s, 4H), 6.77(s, 2H), 6.90–7.09(m, 8H), 7.33–7.52(m, 8H), 9.01(s, 2H) IR(KBr) 3600–2800(br), 1582, 1518, 1491, 1454, 1384, 1328, 1270, 1242, 1191, 1141, 1123, 1046, 1006cm⁻¹ I-865 mp 175–177° C. ¹H NMR(CDCl₃) δ 2.52(s, 12H), 3.11(s, 6H), 5.17(s, 4H), 6.91(s, 2H), 7.11(d, J=8.4Hz, 2H), 7.36–7.52(m, 12H), 7.72 (d, J=2.1Hz, 2H) IR(KBr) 3600–2800(br), 1612, 1520, 1496, 1455, 1364, 1348, 1265, 1184, 1164, 1117, 1005, 971cm⁻¹ I-866 mp 180–182° C. ¹H NMR(CDCl₃) δ 1.77(s, 6H), 1.81(s, 6H), 2.52(s, 12H), 3.22(s, 6H), 4.63(d, J=6.9Hz, 2H), 5.49–5.54(m, 2H), 6.90 (s, 2H), 7.04(d, J=8.4Hz, 2H), 7.50(dd, J=2.1, 8.4Hz, 2H), 7.04(d, J=2.1Hz, 2H) IR(KBr) 3600–2800(br), 1520, 1494, 1365, 1274, 1186, 1161, 1113, 996, 973cm⁻¹ I-867 mp 165–168° C. ¹H NMR(DMSO-d₆) δ 1.72(s, 6H), 1.76(s, 6H), 2.45(s, 12H), 4.55(d, J=6.0Hz, 4H), 5.45–5.55(m, 2H), 6.77(s, 2H), 6.89–6.98(m, 4H), 7.03–7.07(m, 2H), 8.86(br s, 2H) IR(KBr) 3600–2800(br), 1579, 1519, 1497, 1476, 1456, 1384, 1277, 1238, 1195, 1142, 1126, 1050, 994cm⁻¹ I-868 mp 76–78° C. ¹H NMR(CDCl₃) δ 3.47(s, 3H), 3.75(s, 3H), 3.94(s, 3H), 5.15(s, 2H), 5.68(s, 1H), 5.69(s, 1H), 5.92(s, 1H), 6.46(s, 1H), 6.93–7.15(m, 5H), 7.22(d, J=1.5Hz, 1H), 7.34–7.49(m, 5H) IR(CHCl₃) 3528, 1586, 1520, 1489, 1461, 1399, 1287, 1260, 1110, 1070, 1010, 907, 819cm⁻¹ I-869 mp 140–142° C. ¹H NMR(CDCl₃) δ 2.65(s, 3H), 3.13(s, 3H), 3.25(s, 3H), 3.57(s, 3H), 3.78(s, 3H), 3.94(s, 3H), 5.19(s, 2H), 6.85(s, 1H), 7.13–7.19(m, 2H), 7.30–7.50(m, 9H) IR(CHCl₃) 1598, 1516, 1480, 1367, 1266, 1176, 1115, 1081, 1012, 969, 918, 867, 808cm⁻¹

TABLE 172 I-870 mp 189–190° C. ¹H NMR(CDCl₃) δ 1.76(d, J=0.9Hz, 3H), 1.81(s, 3H), 2.69(s, 3H), 3.24(s, 3H), 3.25(s, 3H), 3.58(s, 3H), 3.78(s, 3H), 3.94(s, 3H), 4.64(d, J=6.6Hz, 2H), 5.49(m, 1H), 6.85(s, 1H), 7.10(d, J=8.4Hz, 1H), 7.17(d.d, J=2.1, 8.4Hz, 1H), 7.30–7.42(m, 4H) IR(CHCl₃) 2932, 1599, 1516, 1480, 1367, 1329, 1266, 1177, 1115, 1082, 1032, 1013, 970, 907, 868, 807cm⁻¹ I-871 mp 187–190° C. ¹H NMR(CDCl₃) δ 2.38(s, 3H), 2.64(s, 3H), 3.13(s, 3H), 3.25(s, 3H), 3.58(s, 3H), 3.78(s, 3H), 3.94(s, 3H), 5.14(s, 2H), 6.84(s, 1H), 7.13–7.24(m, 4H), 7.30–7.42(m, 6H) IR(CHCl₃) 2966, 1598, 1517, 1480, 1462, 1368, 1329, 1267, 1177, 1116, 1082, 1032, 970, 907, 867, 808cm⁻¹ I-872 mp 192–194° C. ¹H NMR(CDCl₃) δ 1.15(t, J=6.9Hz, 3H), 1.76(s, 3H), 1.82(s, 3H), 2.59(s, 3H), 3.69(q, J=6.9Hz, 2H), 3.77(s, 3H), 4.61(d, J=6.9Hz, 2H), 4.99(s, 1H), 5.50(m, 1H), 5.70(s, 1H), 6.84(s, 1H), 6.88–6.97(m, 3H), 7.02(d, J=1.8Hz, 1H), 7.52–7.58(m, 2H) IR(CHCl₃) 3536, 2934, 1609, 1520, 1482, 1410, 1365, 1279, 1243, 1172, 1128, 1080, 1029, 972, 952, 872, 833, 812cm⁻¹ I-873 ¹H NMR(CDCl₃) δ 3.46(s, 3H), 3.70(s, 2H), 3.74(s, 3H), 3.75(s, 3H), 5.15(s, 2H), 5.67(s, 1H), 5.90(s, 1H), 6.47(s, 1H), 6.96(d.d, J=8.4 & 1.8Hz, 1H), 7.03(d, J=8.4Hz, 1H), 7.09(d, J=1.8Hz, 1H), 7.33–7.44(m, 7H), 7.61(.d, J=8.4Hz, 2H) IR(KBr) 3536, 3389, 1732, 1587, 1519, 1487, 1438, 1393, 1249, 1217, 1166, 1110, 1069, 1001cm⁻¹ I-874 ¹H NMR(CDCl₃) δ 3.46(s, 3H), 3.74(s, 5H), 5.15(s, 2H), 5.68(s, 1H), 5.91(s, 1H), 6.47(s, 1H), 6.96(d.d, J=8.4 & 1.8Hz, 1H), 7.03(.d, J=8.4Hz, 1H), 7.09(.d, J=8.4Hz, 1H), 7.32–7.49(m, 7H), 7.62(d, J=8.1Hz, 2H) IR(KBr) 3381, 1715, 1698, 1608, 1581, 1523, 1485, 1455, 1396, 1294, 1235, 1112 1072, 1017cm⁻¹ I-875 ¹H NMR(CDCl₃) δ 2.69(s, 3H), 3.13(s, 3H), 3.54(s, 3H), 3.70(s, 2H), 3.74(s, 3H), 3.77(s, 3H), 5.19(s, 2H), 6.86(s, 1H), 7.15(d, J=8.7Hz, 1H), 7.30–7.40(m, 9H), 7.59(.d, J=8.1Hz, 2H) IR(KBr) 1734, 1721, 1606, 1481, 1398, 1361, 1244, 1175, 1120, 1078, 1010cm⁻¹

TABLE 173 I-876 ¹H NMR(CDCl₃) δ 1.76(s, 3H), 1.81(s, 3H), 2.73(s, 3H), 3.23(s, 3H), 3.54(s, 3H), 3.70(s, 2H), 3.74(s, 3H), 3.77(s, 3H), 4.64(d, J=6.9Hz, 2H), 5.46–5.55(m, 1H), 6.86(s, 1H), 7.09(d, J=8.4Hz, 1H), 7.35(d.d, J=8.4 & 2.1Hz, 1H), 7.37 (d, J=8.1Hz, 2H), 7.39(d, J=2.1Hz, 1H), 7.59(d, J=8.1Hz, 2H) ¹H NMR(CDCl₃) δ IR(KBr) 3447, 1735, 1608, 1522, 1482, 1365, 1177, 1117, 1078, 1013cm⁻¹ I-877 ¹H NMR(CDCl₃) δ 1.76(s, 3H), 1.82(s, 3H), 3.46(s, 3H), 3.74(s, 5H), 3H), 4.62(d, J=6.9Hz, 2H), 5.46–5.58(m, 1H), 5.69(s, 1H), 5.89(s, 1H), 6.47(s, 1H), 6.96(s, 2H), 7.06(s, 1H), 7.38(d, J=8.4Hz, 2H), 7.62(d, J=8.4Hz, 2H) I-878 ¹H NMR(CDCl₃) δ 1.76(s, 3H), 1.82(s, 3H), 3.46(s, 3H), 3.70(s, 2H), 3.74(s, 6H), 4.62(d, J=6.9Hz, 2H), 5.46 –5.58(m, 1H), 5.68(s, 1H), 5.88(s, 1H), 6.47(s, 1H), 6.96(s, 2H), 7.06(s, 1H), 7.37(d, J=8.4Hz, 2H), 7.61(d, J=8.4Hz, 2H) IR(KBr) 3527, 3386, 1734, 1609, 1586, 1520, 1487, 1439, 1396, 1219, 1167, 1111, 1068, 1010cm⁻¹ I-879 mp 136–139° C. ¹H NMR(CDCl₃) δ 1.7(br s, 1H), 1.76(s, 3H), 1.81(s, 3H), 2.73(s, 3H), 3.23(s, 3H), 3.53(s, 3H), 3.78(s, 3H), 4.64(d, J=6.7Hz, 2H), 4.78(s, 2H), 5.49(t, J=6.8Hz, 1H), 6.87(s, 1H), 7.09(d, J=8.6Hz, 1H), 7.35(dd, J=8.6, 2.1Hz, 1H), 7.40(d, J=2.1Hz, 1H), 7.47(d, J=8.1Hz, 2H), 7.64(d, J=8.1Hz, 2H) IR(KBr) 3553, 3434, 1481, 1389, 1363, 1235, 1175, 1084, 1011, 972, 806cm⁻¹ I-880 mp 180–181° C. ¹H NMR(CDCl₃) δ 1.70(br s, 1H), 1.76(s, 3H), 1.82(s, 3H), 3.46(s, 3H), 3.75(s, 3H), 4.62(d, J=6.9Hz, 2H), 4.77(s, 2H), 5.53(t, J=6.9Hz, 1H), 5.69(s, 1H), 5.89(s, 1H), 6.47(s, 1H), 6.94–6.96(m, 2H), 7.05–7.07(m, 1H), 7.46(d, J=8.1Hz, 2H), 7.65(d, J=8.4Hz, 2H) IR(KBr) 3509, 3367, 1522, 1487, 1461, 1396, 1289, 1249, 1213, 1116, 1071, 1009, 992, 942, 797, 782cm⁻¹

TABLE 174 I-881 mp 122–123° C. ¹H NMR(CDCl₃) δ 1.77(s, 3H), 1.82(s, 3H), 2.34(t, J=6.5Hz, 1H), 3.22(s, 3H), 3.45(s, 3H), 3.73(s, 3H), 4.5(m, 2H), 4.64(d, J=6.6Hz, 2H), 5.56(t, J=6.6Hz, 1H), 6.84(s, 1H), 6.99–7.10(m, 3H), 7.39(d, J=8.7Hz, 2H), 7.71(d, J=8.7Hz, 2H) IR(KBr) 3579, 1518, 1471, 1360, 1261, 1230, 1148, 1019, 966, 881, 843cm⁻¹ I-882 mp 156–158° C. ¹H NMR(CDCl₃) δ 1.76(s, 3H), 1.81(s, 3H), 2.49(t, J=6.6Hz, 1H), 3.44(s, 3H), 3.72(s, 3H), 4.49(br s, 2H), 4.63(d, J=6.7Hz, 2H), 5.04(s, 1H), 5.55(t, J=6.7Hz, 1H), 6.85(s, 1H), 6.92(d, J=8.9Hz, 2H), 6.98–7.10(m, 3H), 7.53(d, J=8.9Hz, 2H) IR(KBr) 3433, 3234, 1609, 1520, 1472, 1266, 1227, 994, 836cm⁻¹ I-883 mp 168–170° C. ¹H NMR(CDCl₃) δ 2.50(t, J=6.5Hz, 1H), 3.44(s, 3H), 3.73(s, 3H), 4.49(br s, 2H), 4.78(d, J=6.1Hz, 2H), 5.06(s, 1H), 6.24(t, J=6.1Hz, 1H), 6.85(s, 1H), 6.93(d, J=8.6Hz, 2H), 6.97–7.13(m, 3H), 7.53(d, J=8.6Hz, 2H) IR(KBr) 3544, 3412, 3267, 1613, 1521, 1475, 1263, 1229, 1011, 884, 816cm⁻¹ I-884 mp 153–154° C. ¹H NMR(CDCl₃) δ 3.49(s, 3H), 3.77(s, 3H), 5.17(s, 2H), 5.76(brs, 2H), 6.45(s, 1H), 6.91–7.07(m, 3H), 7.26–7.45(m, 5H), 7.93(d, J=8.2Hz, 2H), 8.00(brs, 1H), 8.27(d, J=8.4Hz, 2H) IR(KBr) 3448, 2962, 2938, 1738, 1627, 1604, 1589, 1519, 1486, 1319, 1250, 1153, 1115, 1071, 1011cm⁻¹ I-885 mp 81–82° C. ¹H NMR(CDCl₃) δ 1.51(s, 3H), 1.54(s, 3H), 1.74(s, 3H), 1.77(s, 3H), 2.70(s, 3H), 3.24(s, 3H), 3.60(s, 3H), 3.78(s, 3H), 4.38(d, J=7.5Hz, 2H), 4.65(d, J=6.6Hz, 2H), 6.86(s, 1H), 7.06–7.11(m, 3H), 7.35–7.41(m, 2H), 7.52–7.57(m, 1H) IR(KBr) 3433, 2938, 1699, 1618, 1521, 1481, 1367, 1209, 1178, 1115, 1081, 972, 950, 813, 793cm⁻¹

TABLE 175 I-886 mp 208–209° C. ¹H NMR(CDCl₃) δ 1.77(s, 3H), 1.81(s, 3H), 2.71(s, 3H), 3.23(s, 3H), 3.60(s, 3H), 3.76(s, 3H), 4.64(d, J=7.2Hz, 2H), 5.49(t, J=8.7Hz, 1H), 6.85(s, 1H), 7.09(d, J=8.7Hz, 1H), 7.26–7.40(m, 3H), 7.52–7.58(m, 1H), 7.69–7.73(m, 1H), 8.02 (brs, 1H) IR(KBr) 3357, 2939, 1736, 1606, 1523, 1483, 1398, 1370, 1294, 1243, 1179, 1111, 1079, 965, 827, 814, 795cm⁻¹ I-887 mp 89–90° C. ¹H NMR(CDCl₃) δ 2.34(s, 3H), 2.38(s, 3H), 2.64(s, 3H), 3.12(s, 3H), 3.53(s, 3H), 3.77(s, 3H), 4.92(s, 2H), 5.14(s, 2H), 6.83(s, 1H), 6.89(d, J=8.7Hz, 2H), 7.11–7.46(m, 12H) IR(KBr) 3434, 2939, 1699, 1617, 1520, 1481, 1367, 1211, 1178, 1114, 1081, 952, 813, 794cm⁻¹ I-888 mp 181–182° C. ¹H NMR(CDCl₃) δ 2.38(s, 3H), 2.66(s, 3H), 3.12(s, 3H), 3.59(s, 3H), 3.76(s, 3H), 5.14(s, 2H), 6.85(s, 1H), 7.14–7.41(m, 8H), 7.52–7.58(m, 1H), 7.69–7.73(m, 1H), 8.02(brs, 1H) IR(KBr) 3348, 3030, 2940, 1733, 1607, 1523, 1482, 1397, 1366, 1281, 1242, 1212, 1179, 1128, 1112, 1080, 971, 944, 815, 799cm⁻¹ I-889 mp 155–157° C. ¹H NMR(CDCl₃) δ 1.46(t, J=7.0Hz, 3H), 1.76(s, 3H), 1.82(s, 3H), 2.73(s, 3H), 3.23(s, 3H), 3.56(s, 3H), 3.74(s, 3H), 4.46(q, J=7.4Hz, 2H), 4.65(d, J=7.2Hz, 2H), 5.48–5.54(m, 1H), 6.69(s, 1H), 7.09(d, J=8.4Hz, 2H), 7.28–7.47(m, 4H) IR(KBr) 3434, 2938, 1716, 1579, 1477, 1464, 1409, 1366, 1241, 1178, 1124, 1078, 955, 815, 796cm⁻¹ I-890 mp 82–83° C. ¹H NMR(CDCl₃) δ 2.67(s, 3H), 3.13(s, 3H), 3.58(s, 3H), 3.80(s, 3H), 5.19(s, 2H), 6.84(s, 1H), 7.13–7.49(m, 8H), 7.89–7.96 (m, 2H), 8.27(brs, 1H), 8.27–8.31(m, 1H) IR(KBr) 3447, 3033, 2940, 1743, 1521, 1482, 1367, 1312, 1272, 1249, 1178, 1119, 1080, 957, 817, 799cm⁻¹

TABLE 176 I-891 mp 86–87° C. ¹H NMR(CDCl₃) δ 2.68(s, 3H), 3.10(s, 3H), 3.15(s, 3H), 3.62(s, 3H), 3.81(s, 3H), 5.22(s, 2H), 6.85(s, 1H), 7.16–7.50(m, 9H), 7.88–7.91(m, 2H) IR(KBr) 3413, 2938, 1519, 1483, 1366, 1313, 1162, 1119, 1090, 1079, 957, 812cm⁻¹ I-892 mp 97–98° C. ¹H NMR(CDCl₃) δ 1.53(s, 3H), 1.55(s, 3H), 1.76(s, 3H), 1.78(s, 3H), 3.63(s, 3H), 3.75(s, 3H), 4.26(d, J=7.4Hz, 2H), 4.62(d, J=6.8Hz, 2H), 5.65(brs, 1H), 5.72(brs, 1H), 6.84(s, 1H), 7.04–7.13(m, 3H), 7.35–7.43(m, 2H), 7.51–7.58(m, 1H) IR(KBr) 3453, 3379, 2973, 2931, 1719, 1629, 1529, 1490, 1406, 1313, 1288, 1247, 1193, 1101, 1072, 1015, 993, 816, 786cm⁻¹ I-893 mp 89–90° C. ¹H NMR(DMSO-d₆) δ 1.75(s, 3H), 1.78(s, 3H), 3.31(s, 3H), 3.62(s, 3H), 4.56(d, J=6.9Hz, 2H), 5.52(t, J=6.0Hz, 1H), 6.33(s, 1H), 6.34–6.47(m, 2H), 6.74(brs, 2H), 6.74–6.75(m, 1H), 6.87–6.91(m, 1H), 7.11–7.12(m, 1H), 7.32–7.34(m, 1H), 8.52(brs, 1H), 8.75(brs, 1H) IR(KBr) 3424, 2933, 2614, 1719, 1625, 1585, 1523, 1488, 1408, 1287, 1247, 1125, 1070, 819, 788cm⁻¹ I-894 mp 167–168° C. ¹H NMR(CDCl₃) δ 2.31(s, 3H), 2.38(s, 3H), 3.52(s, 3H), 3.76(s, 3H), 4.91(s, 2H), 5.13(s, 2H), 5.65(brs, 1H), 5.77(brs, 1H), 6.85(s, 1H), 6.84–6.93(m, 2H), 7.10–7.44(m, 12H) IR(KBr) 3425, 2933, 2614, 1719, 1625, 1585, 1522, 1488, 1408, 1287, 1247, 1125cm⁻¹ I-895 mp 93–94° C. ¹H NMR(DMSO-d₆) δ 2.11(s, 3H), 3.34(s, 3H), 3.62(s, 3H), 5.10(s, 2H), 6.32(s, 2H), 6.41–6.49(m, 2H), 6.65(d, J=9.3Hz, 1H), 6.78(s, 1H), 6.95(d, J=8.7Hz, 1H), 7.09–7.14(m, 1H), 7.22(d, J=8.4Hz, 2H), 7.41(d, J=8.1Hz, 2H), 8.49(brs, 1H), 8.87(brs, 1H) IR(KBr) 3424, 2932, 1717, 1626, 1585, 1523, 1488, 1409, 1248, 1125, 1106, 1070, 811, 793cm⁻¹

TABLE 177 I-896 mp 149–150° C. ¹H NMR(DMSO-d₆) δ 1.72(s, 3H), 1.77(s, 3H), 3.32(s, 3H), 3.55(s, 3H), 3.76(s, 6H), 4.55(d, J=6.3Hz, 2H), 5.50(t, J=6.6Hz, 1H), 6.15(s, 1H), 6.68(d, J=2.1Hz, 1H), 6.91(d, J=8.7Hz, 1H), 7.30(s, 2H), 8.41(brs, 1H), 8.74(brs, 1H) IR(KBr) 3423, 2936, 1694, 1578, 1459, 1410, 1319, 1229, 1126, 1067cm⁻¹ I-897 mp 107–108° C. ¹H NMR(CDCl₃) δ 2.70(s, 3H), 3.12(s, 3H), 3.55(s, 3H), 3.72(s, 3H), 3.78(s, 6H), 5.18(s, 2H), 6.65(s, 1H), 6.70(d, J=4.2Hz, 1H), 7.14(d, J=8.4Hz, 1H), 7.26–7.48(m, 9H) IR(KBr) 3434, 2941, 1517, 1488, 1366, 1353, 1261, 1177, 1102, 1074, 844, 818, 796cm⁻¹ I-898 powder ¹H NMR(CDCl₃) δ 1.63(s, 3H), 1.70(s, 3H), 3.48(s, 3H), 3.73–3.76(m, 7H), 3.87(s, 3H), 4.98(s, 1H), 5.24–5.32(m, 2H), 5.90(s, 1H), 6.47(s, 1H), 6.89–7.02(m, 5H), 7.51–7.57(m, 2H) IR(KBr) 3447, 2930, 1612, 1523, 1488, 1455, 1398, 1230, 1120, 1080, 1037, 818, 592cm⁻¹ I-899 mp 171–173° C. ¹H NMR(CDCl₃) δ 1.73(s, 3H), 1.76(s, 3H), 3.48(s, 3H), 3.73–3.76(m, 5H), 4.23(s, 1H), 4.92(s, 1H), 5.37–5.43(m, 1H), 5.84(s, 1H), 6.46(s, 1H), 6.70(d, J=8.1Hz, 1H), 6.86–7.01(m, 5H), 7.51–7.56(m, 2H) IR(KBr) 3392, 2934, 1612, 1526, 1489, 1398, 1222, 1116, 1075, 829, 590cm⁻¹ I-900 mp 78–79° C. ¹H NMR(CDCl₃) δ 2.14(s, 3H), 2.29(s, 3H), 2.36(s, 3H), 3.16(s, 3H), 3.20(s, 3H), 5.22(s, 2H), 7.10(s, 1H), 7.16(d, J=8.7Hz, 1H), 7.22–7.49(m, 11H) IR(CHCl₃) 2939, 1612, 1516, 1476, 1415, 1370, 1291, 1269, 1174, 1150, 1119, 1087, 1018, 971, 954, 873cm⁻¹

TABLE 178 I-901 mp 114–116° C. ¹H NMR(CDCl₃) δ 1.08–1.14(m, 6H), 1.77(s, 3H), 1.81–1.82(d, J=0.6Hz, 3H), 2.53–2.65(m, 4H), 3.21(s, 3H), 3.23(s, 3H), 4.62–4.65(d, J=6.6Hz, 2H), 5.52(m, 1H), 7.04–7.13(m, 2H), 7.23–7.26(m, 2H), 7.32–7.42(m, 5H) IR(CHCl₃) 2970, 2934, 2874, 1674, 1614, 1572, 1517, 1487, 1415, 1370, 1331, 1288, 1262, 1172, 1149, 1109, 971, 937, 872, 849cm⁻¹ I-902 mp 97–99° C. ¹H NMR(CDCl₃) δ 1.07–1.14(m, 6H), 1.77(s, 3H), 1.83(s, 3H), 2.55–2.66(m, 4H), 4.61–4.64(d, J=6.6Hz, 2H), 5.06(s, 1H), 5.54(m, 1H), 5.77(s, 1H), 7.24–7.64(m, 4H), 6.97(d, J=2.1Hz, 1H), 7.10–7.12(d, J=5.7Hz, 2H), 7.23–7.26(m, 2H) IR(CHCl₃) 3596, 3537, 2969, 2933, 27873, 1675, 1612, 1586, 1520, 1489, 1385, 1327, 1290, 1257, 1171, 1125, 996, 903, 877, 836cm⁻¹ I-903 mp 69–71° C. ¹H NMR(CDCl₃) δ 1.78(s, 3H), 1.82(s, 3H), 2.15(s, 3H), 2.30(s, 3H), 2.43(s, 3H), 2.43(s, 3H), 3.21(s, 3H), 3.27(s, 3H), 4.64–4.67(d, J=6.9Hz, 2H), 5.50(s, 2H), 7.10–7.13(d, J=9.9Hz, 2H), 7.23–7.29(m, 2H), 7.34–7.42(m, 5H) IR(CHCl₃) 2939, 1612, 1516, 1476, 1415, 1370, 1331, 1290, 1268, 1174, 1150, 1119, 1086, 971, 954, 873cm⁻¹ I-904 mp 125–127° C. ¹H NMR(CDCl₃) δ 2.27(s, 6H), 3.91(s, 3H), 4.88(br, 1H), 5.20(s, 2H), 6.83–6.96(m, 5H), 7.12–7.13(d, J=4.5Hz, 2H), 7.22–7.50(m, 7H) IR(CHCl₃) 3596, 2957, 2936, 1611, 1586, 1522, 1490, 1464, 1454, 1326, 1257, 1172, 1138, 1033, 835cm⁻¹ I-905 mp 145–146° C. ¹H NMR(CDCl₃) δ 2.26(s, 3H), 2.28(s, 3H), 3.20(s, 3H), 3.91(s, 3H), 5.21(s, 2H), 6.83(dd, J=8.1, 2.1Hz, 1H), 6.91–6.96 (m, 2H), 7.11(s, 1H), 7.15(s, 1H), 7.32–7.50(m, 9H) IR(CHCl₃) 2938, 1604, 1584, 1519, 1488, 1464, 1454, 1373, 1330, 1260, 1175, 1149, 1033, 1018, 970, 873, 847cm⁻¹

TABLE 179 I-906 mp 132–134° C. ¹H NMR(CDCl₃) δ 2.27(s, 3H), 2.87,(s, 3H), 3.91(s, 3H), 5.16(s, 2H), 5.21(s, 2H), 5.70(s, 1H), 6.82–6.86(m, 2H), 6.92–7.00 (m, 4H), 7.13(s, 2H), 7.32–7.50(m, 10H) IR(CHCl₃) 3542, 2936, 2871, 1585, 1519, 1491, 1454, 1382, 1322, 1273, 1175, 1137, 1014, 897, 877, 857cm⁻¹ I-907 mp 181–182° C. ¹H NMR(CDCl₃) δ 1.77(s, 3H), 1.82(s, 3H), 2.13(s, 3H), 2.30(s, 3H), 2.35(s, 3H), 4.61–4.64(d, J=6.9Hz, 2H), 5.37(s, 1H), 5.51(m, 1H), 5.78(s, 1H), 6.81(dd, J=8.1, 2.1Hz, 1H), 6.86–6.97(m, 3H), 7.08(s, 1H), 7.19–7.22(m, 2H), 7.26(s, 1H) IR(CHCl₃) 3595, 3536, 2936, 1613, 1587, 1519, 1479, 1453, 1359, 1330, 1279, 1246, 1173, 1127, 1085, 1024, 974, 950, 881, 867cm⁻¹ I-908 mp 167–168° C. ¹H NMR(CDCl₃) δ 1.77–1.78(d, J=0.9Hz, 3H), 1.84(s, 3H), 2.08(s, 3H), 2.15(s, 3H), 4.63–4.65(d, J=6.9Hz, 2H), 4.82 (s, 1H), 5.05(s, 1H), 5.55(m, 1H), 5.80(m, 1H), 6.74(s, 1H), 6.78(dd, J=8.4, 2.1Hz, 1H), 6.87–6.95(m, 3H), 7.00(d, J=8.4Hz, 1H), 7.23–7.26(m, 2H) IR(CHCl₃) 3594, 3534, 2923, 2869, 1675, 1613, 1584, 1520, 1488, 1455, 1399, 1289, 1247, 1166, 1127, 1091, 994, 948, 835cm⁻¹ I-909 mp 170–172° C. ¹H NMR(DMSO-d₆) δ 1.72(s, 3H), 1.76(s, 3H), 3.31(s, 3H), 3.63(s, 3H), 4.54(d, J=6.5Hz, 2H), 5.17(s, 2H), 5.49(t, J=6.5Hz, 1H), 6.36(s, 1H), 6.63(d, J=8.4Hz, 2H), 6.63(dd, J=8.4, 2.1Hz, 1H), 6.72(d, J=2.1Hz, 1H), 6.88(d, J=8.4Hz, 1H), 7.31(d, J=8.4Hz, 2H), 8.40(s, 1H), 8.70(s, 1H) IR(KBr) 3416, 3329, 1614, 1523, 1489, 1408, 1242, 1219, 1115, 1070, 997, 817, 787cm⁻¹

TABLE 180 I-910 mp 207–209° C. ¹H NMR(CDCl₃) δ 1.54(s, 9H), 2.69(s, 3H), 3.12(s, 3H), 3.52(s, 3H), 3.77(s, 3H), 5.18(s, 2H), 6.56(s, 1H), 6.85(s, 1H), 7.14(d, J=8.7Hz, 1H), 7.32–7.48(m, 9H), 7.57(d, J=8.7Hz, 2H) IR(KBr) 3373, 1734, 1525, 1369, 1227, 1177, 1158, 1080, 816, 793cm⁻¹ I-911 mp 214–216° C. ¹H NMR(DMSO-d₆) δ 2.84(s, 3H), 3.33(s, 3H), 3.46(s, 3H), 3.75(s, 3H), 5.26(s, 2H), 5.30(s, 2H), 6.66(d, J=8.7Hz, 2H), 6.93(s, 1H), 7.24–7.45(m, 8H), 7.52(m, 2H) IR(KBr) 3468, 3386, 1604, 1523, 1482, 1392, 1361, 1175, 1085, 815cm⁻¹ I-912 mp 215–218° C. ¹H NMR(CDCl₃) δ 2.67(s, 3H), 3.13(s, 3H), 3.53(s, 3H), 3.78(s, 3H), 5.19(s, 2H), 6.86(s, 1H), 7.15(d, J=8.4Hz, 1H), 7.32–7.48(m, 7H), 7.69(s, 4H), 8.02(br s, 1H) IR(KBr) 3307, 1733, 1482, 1393, 1361, 1284, 1177, 1084, 1012, 967, 945, 816cm⁻¹ I-913 mp 203–205° C. ¹H NMR(CDCl₃) δ 1.77(s, 3H), 1.81(s, 3H), 2.71(s, 3H), 3.24(s, 3H), 3.54(s, 3H), 3.79(s, 3H), 4.64(d, J=6.8Hz, 2H), 5.50(t, J=6.8Hz, 1H), 6.86(s, 1H), 7.09(d, J=8.4Hz, 1H), 7.35(dd, J=8.4, 2.0Hz, 1H), 7.39(d, J=2.0Hz, 1H), 7.69(s, 4H), 8.01(br s, 1H) IR(KBr) 3311, 1735, 1482, 1393, 1362, 1177, 1083, 976, 945, 818cm⁻¹ I-914 mp 105–107° C. ¹H NMR(CDCl₃) δ 1.76(s, 3H), 1.80(s, 3H), 2.27(s, 3H), 2.29(s, 3H), 3.20(s, 3H), 3.89(s, 3H), 4.63–4.65(d, J=6.6Hz, 2H), 5.57(m, 1H), 6.87–6.96(m, 3H), 7.12(s, 1H), 7.17(s, 1H), 7.33–7.43(m, 4H) IR(CHCl₃) 2937, 2866, 1604, 1583, 1519, 1488, 1464, 1373, 1331, 1259, 1175, 1149, 1035, 970, 873cm⁻¹

TABLE 181 I-915 mp 164–165° C. ¹H NMR(CDCl₃) δ 1.75–1.76(d, J=0.6Hz, 3H), 1.79–1.80(d, J=0.9Hz, 3H), 2.27(s, 3H), 2.28(s, 3H), 3.89(s, 3H), 4.62–4.65(d, J=6.6Hz, 2H), 4.78(br, 1H), 5.57(m, 1H), 6.86–6.96(m, 4H), 7.12(s, 1H), 7.15(s, 1H), 7.22–7.27(m, 3H) IR(CHCl₃) 3596, 2936, 2865, 1676, 1611, 1584, 1522, 1490, 1464, 1385, 1327, 1257, 1172, 1138, 1100, 1035, 996, 952, 896., 835cm⁻¹ I-916 mp 172–173° C. ¹H NMR(CDCl₃) δ 1.72(s, 3H), 1.77(s, 6H), 1.81(s, 3H), 2.70(s, 3H), 3.11(s, 3H), 3.24(s, 3H), 3.57(s, 3H), 3.80(s, 3H), 4.06–4.27(m, 2H), 4.64(d, J=7.2Hz, 2H), 5.37–5.50(m, 2H), 6.85(s, 1H), 7.10(d, J=8.6Hz, 1H), 7.32–7.39(m, 2H), 7.52 (d, J=8.4Hz, 1H), 7.84(d, J=9.6Hz, 1H), 7.94(s, 1H) IR(KBr) 3434, 1519, 1482, 1366, 1346, 1308, 1178, 1157, 1120, 1090, 1078, 957, 805cm⁻¹ I-917 mp 78–80° C. ¹H NMR(CDCl₃) δ 3.47(s, 3H), 3.69(s, 6H), 3.80(s, 6H), 5.14(s, 2H), 5.66(brs, 1H), 5.76(brs, 1H), 6.30(s, 1H), 6.69(d, J=8.2Hz, 2H), 7.02(s, 2H), 7.14(s, 1H), 7.34–7.46(m, 6H) IR(KBr) 3443, 2935, 1614, 1587, 1517, 1470, 1250, 1110, 744cm⁻¹ I-918 mp 83–84° C. ¹H NMR(DMSO-d₆) δ 3.34(s, 3H), 3.72(s, 3H), 5.13(s, 2H), 5.72(brs, 2H), 6.41(s, 1H), 6.62–6.93(m, 4H), 7.32–7.61(m, 7H), 8.54(brs, 1H), 8.88(brs, 1H) IR(KBr) 3398, 2936, 1731, 1633, 1586, 1521, 1489, 1455, 1432, 1402, 1291, 1216, 1112, 1071cm⁻¹ I-919 mp 74–75° C. ¹H NMR(CDCl₃) δ 2.02(s, 6H), 3.11(s, 3H), 3.21(s, 3H), 5.02(brs, 1H), 5.18(s, 2H), 6.96(s, 1H), 7.04–7.18(m, 3H), 7.37–7.59(m, 9H) IR(KBr) 3503, 3032, 2937, 1513, 1474, 1365, 1289, 1197, 1175, 1149, 1114, 970, 867, 811cm⁻¹

TABLE 182 I-920 mp 78–79° C. ¹H NMR(CDCl₃) δ 1.73(s, 3H), 1.78(s, 6H), 1.83(s, 3H), 3.11(s, 3H), 3.48(s, 3H), 3.77(s, 3H), 4.07–4.29(m, 2H), 4.64(d, J=6.8Hz, 2H), 5.41–5.55(m, 2H), 5.73(s, 1H), 5.82(s, 1H), 6.47(s, 1H), 6.94–7.05(m, 3H), 7.53(d, J=8.0Hz, 1H), 7.86(d, J=8.6Hz, 1H), 8.00(s, 1H)IR(KBr) 3449, 2971, 2935, 1519, 1489, 1424, 1338, 1310, 1226, 1152, 1117, 1070, 1059, 773cm⁻¹ I-921 mp 176–177° C. ¹H NMR(CDCl₃) δ 2.10(s, 3H), 2.18(s, 3H), 2.47(s, 3H), 3.12(s, 3H), 3.23(s, 3H), 5.20(s, 2H), 7.09–7.21(m, 3H), 7.39–7.51 (m, 8H), 7.60(d, J=8.4Hz, 2H). IR(KBr) 3433, 3033, 2937, 1516, 1470, 1360, 1291, 1267, 1176, 1150, 1119, 976, 857cm⁻¹ I-922 mp 170–172° C. ¹H NMR(DMSO-d₆) δ 3.36(s, 3H), 3.66(s, 3H), 4.22(br d, J=2.5Hz, 2H), 4.50(t, J=4.5Hz, 1H), 4.57(d, J=5.7Hz, 2H), 4.60(d, J=5.7Hz, 2H), 4.97(t, J=5.7Hz, 2H), 5.17(s, 2H), 5.23(t, J=5.7Hz, 1H), 6.93(s, 1H), 7.04(d, J=8.4Hz, 1H), 7.14(dd, J=8.4, 2.3Hz, 1H), 7.28–7.37(m, 2H), 7.40–7.45(m, 4H), 7.49–7.53(m, 2H), 7.61(d, J=8.1Hz, 2H) IR(KBr) 3322, 1462, 1385, 1228, 1037, 1006, 750, 700cm⁻¹ I-923 mp 130–132° C. ¹H NMR(CDCl₃) δ 1.55(s, 9H), 1.62(s, 3H), 2.30(s, 12H), 3.00(s, 6H), 6.73(br s, 1H), 6.78–6.82(m, 2H), 7.07–7.14(m, 4H), 7.24–7.27(m, 2H), 8.07–8.13(m, 2H) IR(KBr) 3600–2800(br), 1732, 1624, 1610, 1583, 1530, 1493, 1366, 1347, 1320, 1236, 1154cm⁻¹ I-924 mp 104–106° C. ¹H NMR(CDCl₃) δ 2.27(s, 3H), 2.30(s, 3H), 3.00(s, 6H), 3.74(br s, 2H), 6.77–6.85(m, 3H), 6.96(dd, J=1.8, 8.1Hz, 1H), 7.03(dd, J=2.1, 12.0Hz, 1H), 7.09(s, 1H), 7.13(s, 1H), 7.24–7.29(m, 2H) IR(KBr) 3600–2800(br), 1631, 1608, 1580, 1530, 1487, 1436, 1363, 1233, 1195cm⁻¹

TABLE 183 I-925 mp 100–102° C. ¹H NMR(CDCl₃) δ 1.75(d, J=0.6Hz, 3H), 1.78(d, J=0.6Hz, 3H), 2.29(s, 3H), 2.30(s, 3H), 3.00(s, 6H), 3.77(d, J=6.6Hz, 2H), 3.87(br s, 2H), 5.37–5.40(m, 1H), 6.71–6.83(m, 3H), 7.00–7.03(m, 2H), 7.11(s, 1H), 7.13(s, 1H), 7.25–7.29(m, 2H) IR(KBr) 3600–2800(br), 1623, 1610, 1529, 1490, 1441, 1348, 1328, 1253, 1229, 1120, 1065cm⁻¹ I-926 mp 178–180° C. ¹H NMR(CDCl₃) δ 2.27(s, 3H), 2.32(s, 3H), 3.01(s, 6H), 6.78–6.83(m, 2H), 7.10(s, 1H), 7.16(s, 1H), 7.18–7.28(m, 4H), 8.12(br s, 1H), 8.27–8.33(m, 1H) IR(KBr) 3600–2800(br), 1709, 1613, 1532, 1490, 1356, 1283, 1229, 1188, 1167cm⁻¹ I-927 mp 154–156° C. ¹H NMR(CDCl₃) δ 1.94(d, J=1.2Hz, 3H), 2.26(d, J=1.2Hz, 3H), 2.27(s, 3H), 2.31(s, 3H), 3.00(s, 6H), 5.79–5.80(m, 1H), 6.78–6.82(m, 3H), 7.09–7.16(m, 4H), 7.16–7.24(m, 2H), 8.38–8.44(m, 1H) IR(KBr) 3600–2800(br), 1681, 1665, 1643, 1610, 1528, 1506, 1487, 1442, 1359, 1317, 1237, 1198, 1159cm⁻¹ I-928 mp 183–185° C. ¹H NMR(CDCl₃) δ 1.44(t, J=7.5Hz, 3H), 2.27(s, 3H), 2.31(s, 3H), 3.16–3.23(m, 2H), 6.53(d, J=2.4Hz, 1H), 6.78–6.82 (m, 2H), 7.09(s, 1H), 7.14–7.18(m, 3H), 7.24–7.27(m, 3H), 7.59–7.65(m, 1H) IR(KBr) 3600–2800(br), 1607, 1527, 1491, 1451, 1436, 1359, 1336, 1271, 1222, 1153, 1110cm⁻¹ I-929 mp 184–186° C. ¹H NMR(CDCl₃) δ 2.26(s, 3H), 2.32(s, 3H), 3.01(s, 6H), 6.78–6.83(m, 2H), 7.10(s, 1H), 7.18(s, 1H), 7.23–7.27(m, 1H), 7.65(dd, J=1.8, 8.1Hz, 1H), 7.70(d, J=2.1Hz, 1H), 8.19–8.24(m, 1H) IR(KBr) 3600–2800(br), 1721, 1612, 1536, 1490, 1325, 1282, 1242, 1197, 1169, 1123, 1054cm⁻¹

TABLE 184 I-930 mp 212–215° C. ¹H NMR(DMSO-d₆) δ 2.83(s, 3H), 3.43(s, 3H), 3.45(s, 3H), 3.52(s, 3H), 3.79(s, 3H), 4.87(s, 2H), 7.08(s, 1H), 7.21(d, J=8.4Hz, 1H), 7.27–7.32(m, 2H), 7.48(d, J=8.7Hz, 2H), 7.74(d, J=8.7Hz, 2H) IR(Nujol) 1731, 1604, 1519, 1480, 1237, 1174, 1081, 1013, 876, 839, 822, 804cm⁻¹ I-931 mp 166–168° C. ¹H NMR(CDCl₃) δ 3.45(s, 3H), 3.75(s, 3H), 4.67(d, J=9.0Hz, 2H), 6.45(s, 1H), 6.78(t, J=9.0Hz, 1H), 6.92(d, J=8.7Hz, 2H), 6.92(d, J=8.4Hz, 1H), 6.98(dd, J=8.4, 2.1Hz, 1H), 7.09(d, J=2.1Hz, 1H), 7.53(d, J=8.7Hz, 2H) IR(Nujol) 3399, 1611, 1588, 1523, 1488, 1460, 1224, 1113, 1070, 1012, 939, 825, 813, 795cm⁻¹ I-932 foam ¹H NMR(CDCl₃) δ 3.45(s, 3H), 3.75(s, 3H), 4.64–4.74(m, 3H), 6.45(s, 1H), 6.92(d, J=8.7Hz, 2H), 6.93(d, J=8.4,Hz, 1H), 6.97(dd, J=8.4, 2.1Hz, 1H), 7.08(d, J=2.1Hz, 1H), 7.53(d, J=8.7Hz, 2H) IR(Nujol) 3570, 3461, 3357, 3180, 1753, 1616, 1596, 1524, 1495, 1408, 1313, 1287, 1264, 1240, 1200, 1114, 1073, 1011, 906, 825cm⁻¹ I-933 mp 120–123° C. ¹H NMR(CDCl₃) δ 1.69(s, 3H), 1.74(s, 6H), 1.80(s, 3H), 3.49(s, 3H), 6.68–3.75(m, 5H), 4.58(d, J=6.6Hz, 2H), 5.31–5.41 (m, 1H), 5.50–5.56(m, 1H), 5.81(s, 1H), 6.46(s, 1H), 6.68–6.74(m, 2H), 6.85–6.93(m, 3H), 7.50–7.56(m, 2H) IR(KBr) 3460, 2969, 2929, 1609, 1523, 1490, 1398, 1247, 1117, 1078, 1013, 824, 778, 708, 589cm⁻¹ I-934 mp 171–173° C. ¹H NMR(CDCl₃) δ 1.75(s, 3H), 1.80(s, 3H), 3.47(s, 3H), 3.73(s, 3H), 3.81(s, 2H), 4.58(d, J=6.9Hz, 2H), 5.50–5.57(m, 1H), 5.82(s, 1H), 6.44(s, 1H), 6.77–6.94(m, 5H), 7.50–7.55(m, 2H) IR(KBr) 3382, 3320, 2929, 1613, 1523, 1490, 1405, 1262, 1221, 1120, 1067, 1011, 844, 818, 598cm⁻¹

TABLE 185 I-935 mp 220–221° C. ¹H NMR(DMSO-d₆) δ 1.74(s, 3H), 1.77(s, 3H), 2.08(s, 3H), 3.30(s, 3H), 3.64(s, 3H), 4.64(d, J=7.2Hz, 2H), 5.48–5.54 (m, 1H), 6.40(s, 1H), 6.80–6.87(m, 2H), 6.93–7.03(m, 2H), 7.42–7.46(m, 2H), 7.85(s, 1H), 8.58(s, 1H), 8.96(s, 1H), 9.56(s, 1H) IR(KBr) 3476, 3400, 3322, 2935, 1658, 1610, 1542, 1520, 1487, 1270, 1258, 1225, 1115, 1010, 825, 596cm⁻¹ I-936 mp 149–150° C. ¹H NMR(CDCl₃) δ 1.48(s, 3H), 1.67(s, 3H), 1.76(s, 3H), 1.80(s, 3H), 3.63(s, 3H), 3.74(s, 3H), 4.27(d, J=7.5Hz, 2H), 4.63(d, J=6.6Hz, 2H), 5.01(s, 1H), 5.20–5.28(m, 1H), 5.52–5.60(m, 1H), 6.66(s, 1H), 6.91(d, J=8.7Hz, 2H), 7.01(t, J=8.7Hz, 1H), 7.10–7.22(m, 2H), 7.48(d, J=8.7Hz, 2H) IR(KBr) 3335, 2936, 1671, 1614, 1596, 1522, 1441, 1403, 1369, 1265, 1233, 1111, 1077, 1008, 945, 832cm⁻¹ I-937 mp 122–123° C. ¹H NMR(CDCl₃) δ 3.44(s, 3H), 3.76(s, 3H), 4.77(d, J=6.3Hz, 2H), 5.05(s, 1H), 6.04(s, 1H), 6.24(t, J=6.3Hz, 1H), 6.45(s, 1H), 6.92(d, J=8.7Hz, 2H) 7.01(t, J=8.7Hz, 1H), 7.19–7.30(m, 2H), 7.53(d, J=8.7Hz, 2H) IR(KBr) 3582, 3502, 3237, 2950, 1614, 1524, 1490, 1453, 1403, 1301, 13267, 1231, 1112, 1073, 1019, 881, 827cm⁻¹ I-938 mp 143–144° C. ¹H NMR(CDCl₃) δ 1.79(s, 3H), 1.84(s, 3H), 2.10(s, 3H), 2.17(s, 3H), 2.47(s, 3H), 3.23(s, 3H), 3.24(s, 3H), 4.66(d, J=6.6Hz, 2H), 5.20–5.55(m, 1H), 7.09–7.16(m, 4H), 7.40(d, J=8.7Hz, 2H), 7.60(d, J=8.1Hz, 2H) IR(KBr) 3433, 2935, 1513, 1472, 1366, 1188, 1178, 1152, 1117, 974, 857cm⁻¹ I-939 mp 80–81° C. ¹H NMR(CDCl₃) δ 3.47(s, 3H), 3.48(s, 3H), 3.68(s, 3H), 3.81(s, 6H), 4.79(s, 2H), 5.13(s, 2H), 5.14(s, 2H), 5.65(s, 1H), 5.75(s, 1H), 6.28(s, 1H), 6.69(s, 2H), 7.01(s, 2H), 7.14(s, 1H), 7.40–7.45(m, 5H) IR(KBr) 3433, 2937, 1720, 1582, 1508, 1455, 1407, 1285, 1239, 1125, 1069, 1051, 1011cm⁻¹

TABLE 186 I-940 mp 71–72° C. ¹H NMR(CDCl₃) δ 1.76(s, 3H), 1.81(s, 3H), 2.73(s, 3H), 3.21(s, 3H), 3.55(s, 3H), 3.72(s, 3H), 3.78(s, 6H), 4.63(d, J=6.8Hz, 2H), 5.46–5.52(m, 1H), 6.65(s, 1H), 6.70(d, J=3.8Hz, 2H), 7.07(d, J=8.4Hz, 1H), 7.34–7.46(m, 3H) IR(KBr) 3433, 2938, 1674, 1609, 1587, 1518, 14732, 1365, 1252, 1178, 1109, 1077, 971, 945, 815, 796cm⁻¹ I-941 mp 98–99° C. ¹H NMR(CDCl₃) δ 1.74(s, 3H), 1.78(s, 3H), 3.50(s, 3H), 3.71(s, 3H), 3.72(d, J=8.1Hz, 2H), 5.35(t, J=7.2Hz, 1H), 5.64(s, 1H), 5.77(s, 1H), 6.43(s, 1H), 7.02–7.15(m, 3H), 7.32–7.41(m, 2H), 7.49–7.56(m, 1H) IR(KBr) 3408, 2934, 1627, 1529, 1491, 1444, 1405, 1246, 1175, 1102, 1069, 822, 783cm⁻¹ I-942 ¹H NMR(CDCl₃) δ 1.77(s, 3H), 1.82(s, 3H), 2.68(s, 3H), 2.73(s, 3H), 3.25(s, 3H), 3.60(s, 3H), 3.81(s, 3H), 4.65(d, J=6.3Hz, 2H), 5.44–5.53(m, 1H), 6.87(s, 1H), 7.10(d, J=8.7Hz, 1H), 7.30–7.47(m, 3H), 7.84(d.d, J=7.8 & 2.1Hz, 1H), 8.22(d, J=2.1Hz, 1H) IR(KBr) 1530, 1480, 1362, 1272, 1237, 1179, 1077cm⁻¹ I-943 ¹H NMR(CDCl₃) δ 2.69(s, 3H), 3.12(s, 3H), 3.56(s, 3H), 3.77(s, 3H), 3.84(s, 2H), 5.18(s, 2H), 6.82(s, 1H), 6.84(d, J=8.1Hz, 1H), 7.14(d, J=8.4Hz, 1H), 7.21–7.50(m, 9H) IR(KBr) 3466, 3377, 1634, 1583, 1525, 1488, 1461, 1400, 1288, 1245, 1196, 1105, 1069cm⁻¹ I-944 ¹H NMR(CDCl₃) δ 1.76(s, 3H), 1.82(s, 3H), 3.49(s, 3H), 3.75(s, 3H), 4.61(d, J=6.6Hz, 2H), 5.48–5.57(m, 1H), 5.59–5.75 (m, 1H), 5.88(s, 1H), 6.43(s, 1H), 6.83–7.07(m, 4H), 7.21–7.30(m, 1H), 7.35(d.d, J=12.3 & 1.8Hz, 2H) IR(KBr) 3465, 3377, 1634, 1525, 1488, 1460, 1400, 1287, 1245, 1195, 1105, 1068cm⁻¹ I-945 ¹H NMR(CDCl₃) δ 2.02(s, 6H), 2.15(s, 3H), 3.20(s, 3H), 5.20(s, 3H), 6.81–6.86(m, 1H), 6.93(d.d, J=10.7 & 2.1Hz, 1H), 6.97(s, 1H), 7.04–7.12(m, 1H), 7.31–7.52(m, 9H) IR(KBr) 1513, 1468, 1362, 1295, 1264, 1227, 1193, 1171, 1151, 1003, 965cm⁻¹

TABLE 187 I-946 ¹H NMR(CDCl₃) δ 2.02(s, 6H), 2.15(s, 3H), 3.20(s, 3H), 5.14(d, J=3.9Hz, 1H), 6.81–6.86(m, 1H), 6.91(d.d, J=10.1 & 2.1Hz, 1H), 6.97(s, 1H), 7.04–7.12(m, 1H), 7.30–7.42(m, 4H) IR(KBr) 3414, 1624, 1595, 1518, 1473, 1360, 1294, 1170, 1144, 1120, 1104, 1016cm⁻¹ I-947 ¹H NMR(CDCl₃) δ 1.77(s, 3H), 1.82(s, 3H), 2.02(s, 6H), 2.16(s, 3H), 3.20(s, 3H), 4.64(d, J=6.6Hz, 2H), 5.53–5.61(m, 1H), 6.82–7.09(m, 4H), 7.33(d, J=9.0Hz, 2H), 7.39(d, J=9.0Hz, 2H) IR(KBr) 1514, 1468, 1376, 1294, 1262, 1175, 1152, 992, 968cm⁻¹ I-948 ¹H NMR(CDCl₃) δ 1.77(s, 3H), 1.82(s, 3H), 2.02(s, 6H), 2.17(s, 3H), 4.64(d, J=6.6Hz, 2H), 4.81(s, 1H), 5.52–5.60(m, 1H), 6.82–7.08(m, 6H), 7.22(.d, J=8.7Hz, 2H) IR(KBr) 3568, 3417, 1613, 1517, 1471, 1287, 1261, 1230, 1192, 1132, 1102, 1001cm⁻¹ I-949 ¹H NMR(CDCl₃) δ 3.02(s, 6H), 3.46(s, 3H), 3.75(s, 3H), 5.18(s, 2H), 6.03(s, 1H), 6.47(s, 1H), 6.82(d, J=8.7Hz, 2H), 7.03–7.51(m, 8H), 7.55(.d, J=8.7Hz, 2H) IR(KBr) 3502, 1604, 1527, 1488, 1359, 1267, 1233, 1198, 1110, 1070cm⁻¹ I-950 ¹H NMR(CDCl₃) δ 2.60(s, 3H), 3.03(s, 6H), 3.54(s, 3H), 3.76(s, 3H), 5.21(s, 2H), 6.80(d, J=8.7Hz, 2H), 6.86(s, 1H), 7.03–7.49(m, 8H), 7.54(.d, J=8.7Hz, 2H) IR(KBr) 1602, 1530, 1483, 1444, 1395, 1366, 1233, 1179, 1078, 1015cm⁻¹ I-951 ¹H NMR(CDCl₃) δ 2.76(s, 3H), 3.02(s, 6H), 3.54(s, 3H), 3.76(s, 3H), 5.28(s, 1H), 6.81(d, J=9.0Hz, 2H), 6.86(s, 1H), 7.04–7.23(m, 3H), 7.54(d, J=9.0Hz, 2H) IR(KBr) 3375, 1607, 1530, 1483, 1395, 1346, 1292, 1228, 1163, 1077, 1009cm⁻¹ I-952 ¹H NMR(CDCl₃) δ 1.76(s, 3H), 1.80(s, 3H), 2.71(s, 3H), 3.02(s, 6H), 3.55(s, 3H), 3.76(s, 3H), 4.63(d, J=6.9Hz, 2H), 5.49–5.57(m, 1H), 6.82(.d, J=8.7Hz, 2H), 6.86(s, 1H), 7.01–7.23(m, 3H), 7.54(d, J=8.7Hz, 2H) IR(KBr) 1602, 1531, 1484, 1389, 1369, 1258, 1235, 1197, 1176, 1084cm⁻¹

TABLE 188 I-953 ¹H NMR(CDCl₃) δ 1.76(s, 3H), 1.80(s, 3H), 3.02(s, 6H), 3.47(s, 3H), 3.75(s, 3H), 4.63(d, J=6.9Hz, 2H), 5.51–5.60(m, 1H), 6.03(s, 1H), 6.47(s, 1H), 6.82(.d, J=8.7Hz, 2H), 6.99–7.08(m, 1H), 7.16–7.29(m, 2H), 7.55(d, J=8.7Hz, 2H) IR(KBr) 3498, 1604, 1528, 1488, 1360, 1266, 1234, 1198, 1110, 1067cm⁻¹ I-954 ¹H NMR(CDCl₃) δ 3.02(s, 6H), 3.47(s, 3H), 3.75(s, 3H), 5.14(s, 1H), 6.03(s, 1H), 6.47(s, 1H), 6.82(d, J=9.0Hz, 2H), 7.02–7.09(m, 1H), 7.15–7.29(m, 2H), 7.55(d, J=9.0Hz, 2H) IR(KBr) 3492, 3383, 1607, 1529, 1488, 1397, 1223, 1103, 1065, 1006cm⁻¹ I-955 ¹H NMR(CDCl₃) δ 2.01(s, 6H), 2.17(s, 3H), 4.75(s, 1H), 5.19(s, 2H), 6.83–7.15(m, 7H), 7.30–7.53(m, 6H) IR(KBr) 3542, 1607, 1579, 1513, 1469, 1263, 1126, 1107, 1015cm⁻¹ I-956 ¹H NMR(CDCl₃) δ 1.76(s, 3H), 1.82(s, 3H), 2.66(s, 3H), 3.50(s, 3H), 3.77(s, 3H), 4.62(d, J=6.4Hz, 2H), 5.48–5.56(m, 1H), 5.71(s, 1H), 5.81(s, 1H), 5.47(s, 1H), 6.90–7.00(m, 2H), 7.04(d, J=1.8Hz, 1H), 7.42(.d, J=7.8Hz, 2H), 7.82(d.d, J=7.8 & 1.8Hz, 1H), 8.26(.d, J=1.5Hz, 1H) IR(KBr) 3520, 3419, 1585, 1529, 1506, 1344, 1313, 1290, 1251, 1226, 1118, 1079cm⁻¹ I-957 mp 123–126° C. ¹H NMR(CDCl₃) δ 1.75(s, 3H), 1.78(d, J=0.9Hz, 3H), 3.47(s, 3H), 3.75(s, 3H), 3.87(s, 3H), 3.88(s, 3H), 4.63(d, J=6.6Hz, 2H), 5.57(m, 1H), 5.92(s, 1H), 6.47(s, 1H), 6.95–7.40(m, 5H), 7.56–7.62(m, 2H) IR(CHCl₃) 3510, 2934, 1608, 1519, 1489, 1461, 1394, 1285, 1243, 1175, 1115, 1075, 1034, 1008, 926, 823cm⁻¹ I-958 mp 163–164° C. ¹H NMR(CDCl₃) δ 1.75(s, 3H), 1.78(s, 3H), 3.61(s, 3H), 3.65(s, 3H), 3.75(s, 3H), 3.88(s, 3H), 4.64(d, J=6.6Hz, 2H), 4.99(s, 1H), 5.58(m, 1H), 6.68(s, 1H), 6.88–6.98(m, 5H), 7.46–7.52(m, 2H) IR(CHCl₃) 3592, 2934, 1610, 1517, 1461, 1387, 1237, 1171, 1136, 1111, 1084 1036, 1012, 830cm⁻¹

TABLE 189 I-959 mp 142–146° C. ¹H NMR(CDCl₃) δ 1.76(s, 3H), 1.82(s, 3H), 3.47(s, 3H), 3.75(s, 3H), 3.94(s, 3H), 4.61(d, J=6.6Hz, 2H), 5.53(m, 1H), 5.69(s, 1H), 5.70(s, 1H), 5.91(s, 1H), 6.46(s, 1H), 6.94–7.26(m, 6H) IR(CHCl₃) 3526, 2930, 1585, 1520, 1489, 1460, 1399, 1287, 1260, 1110, 1070, 1010, 819cm⁻¹ I-960 mp 141–145° C. ¹H NMR(CDCl₃) δ 2.39(s, 3H), 3.47(s, 3H), 3.94(s, 3H), 5.10(s, 2H), 5.68(s, 1H), 5.69(s, 1H), 5.92(s, 1H), 6.46(s, 1H), 6.93–7.38(m, 6H) IR(CHCl₃) 3528, 1585, 1519, 1489, 1460, 1399, 1260, 1110, 1070, 1009, 863cm⁻¹ I-961 mp 152–154° C. ¹H NMR(CDCl₃) δ 2.26(s, 3H), 4.79(br, 1H), 5.19(s, 2H), 6.87–6.90(m, 2H), 7.03–7.15(m, 4H), 7.22–7.26(m, 2H), 7.34–7.50 (m, 6H) IR(CHCl₃) 3596, 2925, 2869, 1612, 1581, 1523, 1490, 1455, 1383, 1313, 1298, 1259, 1171, 1125, 1100, 1012, 956, 877, 836cm⁻¹ I-962 mp 150–151° C. ¹H NMR(CDCl₃) δ 2.28(s, 3H), 3.90(s, 3H), 4.77–4.79(d, J=6.0Hz, 2H), 6.26(d, J=6.0Hz, 1H), 6.88–6.91(m, 5H), 7.13–7.14(d, J=2.7Hz, 2H), 7.24–7.27(m, 2H) IR(CHCl₃) 3596, 2958, 1732, 1612, 1587, 1522, 1490, 1464, 1325, 1257, 1172, 1139, 1100, 1032, 886, 835cm⁻¹ I-963 mp 93–94° C. ¹H NMR(CDCl₃) δ 2.27(s, 3H), 4.76–4.79(d, J=6.0Hz, 2H), 5.12(br, 1H), 6.24(t, J=6.0Hz, 1H), 6.88–7.15(m, 7H), 7.22–7.26(m, 2H) IR(CHCl₃) 3596, 2925, 2867, 1613, 1583, 1523, 1490, 1458, 1424, 1388, 1258, 1171, 1126, 1100, 1022, 956, 886, 836cm⁻¹

TABLE 190 I-964 foam ¹H NMR(CDCl₃) δ 3.47(s, 3H), 3.74(s, 3H), 5.06(s, 1H), 5.15(s, 2H), 5.70(s, 1H), 5.94(s, 1H), 6.46(s, 1H), 6.81–7.50(m, 12H) IR(CHCl₃) 3534, 1609, 1587, 1518, 1504, 1482, 1463, 1455, 1407, 1322, 1290, 1249, 1200, 1112, 1072, 1011cm⁻¹ I-965 foam ¹H NMR(CDCl₃) δ 3.61(s, 3H), 3.75(s, 3H), 5.16(s, 2H), 5.72(s, 2H), 6.46(s, 1H), 6.83(s, 1H), 6.94(dd, J=2.0, 8.4Hz, 1H), 7.00–7.12(m, 4H), 7.29–7.50(m, 7H) IR(CHCl₃) 3531, 1587, 1516, 1498, 1482, 1462, 1455, 1410, 1362, 1308, 1288, 1248, 1202, 1121, 1092, 1070, 1006cm⁻¹ I-966 mp 174–175° C. ¹H NMR(CDCl₃) δ 2.28(s, 3H), 3.38(s, 3H), 3.71(s, 3H), 5.16(s, 2H), 5.68(s, 1H), 5.88(s, 1H), 6.30(s, 1H), 6.98(dd, J=1.8, 8.4Hz, 1H), 7.04(d, J=8.4Hz, 1H), 7.11(d, J=1.8Hz, 1H), 7.22–7.49(m, 9H) IR(KBr) 3516, 3398, 1587, 1516, 1500, 1484, 1453, 1412, 1306, 1285, 1247, 1231, 1202, 1126, 1101, 1072, 1019, 769, 737cm⁻¹ I-967 mp 103–104° C. ¹H NMR(CDCl₃) δ 2.26(s, 6H), 4.61–4.78(m, 3H), 4.84(s, 1H), 6.84–6.92(m, 2H), 6.97–7.16(m, 5H), 7.21–7.27(m, 2H) IR(KBr) 3409, 1742, 1523, 1489, 1315, 1295, 1259, 1231, 1206, 1193, 1124, 1001, 834, 815cm⁻¹ I-968 mp 90–91° C. ¹H NMR(CDCl₃) δ 1.77(s, 6H), 1.82(d, J=0.9Hz, 6H), 2.27(s, 6H), 4.56(d, J=6.6Hz, 2H), 5.13(d, J=6.6Hz, 2H), 5.49–5.60(m, 2H), 6.94–7.00(m, 2H), 7.01–7.14(m, 5H), 7.25–7.31(m, 2H) IR(KBr) 1608, 1522, 1488, 1378, 1299, 1288, 1273, 1259, 1242, 1196, 1176, 1014, 831, 811, 776cm⁻¹

TABLE 191 I-969 mp 200–203° C. ¹H NMR(CDCl₃) δ 2.00(s, 3H), 2.25(s, 3H), 3.46(s, 3H), 3.73(s, 3H), 3.83(s, 3H), 5.25(s, 1H), 6.01–6.03(m, 1H), 6.06(s, 1H), 6.45(s, 1H), 6.86–6.90(m, 2H), 7.04–7.14(m, 3H), 7.47–7.52(m, 2H) IR(KBr) 3433, 2937, 1721, 1651, 1523, 1489, 1398, 1264, 1225, 1136, 1071, 1035, 927, 823, 530cm⁻¹ I-970 mp 157–160° C. ¹H NMR(CDCl₃) δ 1.74(s, 3H), 1.80(s, 3H), 2.86(s, 3H), 3.49(s, 3H), 3.75(s, 3H), 4.57(d, J=6.6Hz, 2H), 5.08(s, 1H), 5.50–5.57(m, 1H), 5.82(s, 1H), 6.46(s, 1H), 6.66(d, J=2.1Hz, 1H), 6.73(dd, J=2.1, 8.1Hz, 1H), 6.86–6.94(m, 3H), 7.50–7.56 (m, 2H) IR(KBr) 3392, 2934, 1611, 1523, 1490, 1397, 1242, 1216, 1112, 1074, 1002, 592cm⁻¹ I-971 mp 153–155° C. ¹H NMR(CDCl₃) δ 1.77(s, 3H), 1.82(s, 3H), 2.10(s, 3H), 3.20(s, 3H), 3.21(s, 3H), 3.36(s, 3H), 3.71(s, 3H), 4.63(d, J=6.9Hz, 2H), 5.52(t, J=6.9Hz, 1H), 6.73(s, 1H), 7.06(d, J=8.4Hz, 1H), 7.14(dd, J=8.4, 2.1Hz, 1H), 7.23(d, J=2.1Hz, 1H), 7.36(d, J=8.9Hz, 2H), 7.69(d, J=8.9Hz, 2H) IR(KBr) 1515, 1474, 1365, 1229, 1175, 1151, 1096, 973, 870, 810cm⁻¹ I-972 amorphous ¹H NMR(CDCl₃) δ 1.77(s, 3H), 1.82(s, 3H), 2.43(s, 3H), −3.44(s, 3H), 3.71(s, 3H), 4.49(d, J=9.9Hz, 2H), 4.62(d, J=6.6Hz, 2H), 4.72(d, J=7.2Hz, 2H), 5.53(t, J=6.6Hz, 1H), 6.86(s, 1H), 6.96(d, J=8.7Hz, 1H), 7.21–7.30(m, 4H), 7.54(d, J=8.1Hz, 2H) IR(KBr) 3599, 1463, 1386, 1081, 1007cm⁻¹

TABLE 192 I-973 mp 83–86° C. ¹H NMR(DMSO-d₆) δ 1.74(s, 3H), 1.77(s, 3H), 3.36(s, 3H), 3.65(s, 3H), 4.23(d, J=23.1Hz, 2H), 4.48(t, J=4.4Hz, 1H), 4.52(d, J=5.4Hz, 2H), 4.52–4.60(m, 4H), 4.89(t, J=5.6Hz, 1H), 5.22(t, J=5.9Hz, 1H), 5.48(t, J=6.6Hz, 1H), 6.92 (s, 1H), 6.96(d, J=8.6Hz, 1H), 7.12(dd, J=8.6, 1.5Hz, 1H), 7.26(d, J=1.5Hz, 1H), 7.42(d, J=8.0Hz, 2H), 7.61(d, J=8.0Hz, 2H) IR(KBr) 3399, 1464, 1386, 1230, 1005cm⁻¹ I-974 mp 177–179° C. ¹H NMR(CDCl₃) δ 1.31(d, J=6.9Hz, 6H), 2.70(s, 3H), 2.98(sept, J=6.9Hz, 1H), 3.12(s, 3H), 3.54(s, 3H), 3.76(s, 3H), 5.19(s, 2H), 6.87(s, 1H), 7.15(d, J=8.4Hz, 1H), 7.30–7.49(m, 9H), 7.54(d, J=7.8Hz, 2H) IR(KBr) 1512, 1480, 1369, 1176, 1084, 1014, 813, 798cm⁻¹ I-975 mp 180–182° C. ¹H NMR(CDCl₃) δ 1.31(d, J=6.6Hz, 6H), 1.76(s, 3H), 1.81(s, 3H), 2.74(s, 3H), 2.98(sept, J=6.6Hz, 1H), 3.22(s, 3H), 3.54(s, 3H), 3.77(s, 3H), 4.63(d, J=6.7Hz, 2H), 5.49(t, J=6.7Hz, 1H), 6.87(s, 1H), 7.08(d, J=8.4Hz, 1H), 7.31(d, J=8.1Hz, 2H), 7.35(dd, J=8.4, 2.1Hz, 1H), 7.40(d, J=2.1Hz, 1H), 7.54(d, J=8.1Hz, 2H) IR(KBr) 1520, 1481, 1366, 1177, 1083, 1012, 975, 944, 815, 797cm⁻¹ I-976 mp 125–126° C. ¹H NMR(CDCl₃) δ 1.31(d, J=6.9Hz, 6H), 1.76(s, 3H), 1.82(s, 3H), 2.97(sept, J=6.9Hz, 1H), 3.46(s, 3H), 3.74(s, 3H), 4.61(d, J=7.1Hz, 2H), 5.53(t, J=7.1Hz, 1H), 5.68(s, 1H), 5.91(s, 1H), 6.48(s, 1H), 6.95–6.96(m, 2H), 7.06–7.07(m, 1H), 7.31(d, J=8.0Hz, 2H), 7.57(d, J=8.0Hz, 2H) IR(KBr)cm⁻¹

TABLE 193 I-977 foam ¹H NMR(CDCl₃) δ 2.68(s, 3H), 3.13(s, 3H), 3.20(s, 3H), 3.57(s, 3H), 3.79(s, 3H), 5.19(s, 2H), 6.86(s, 1H), 7.15(d, J=8.7Hz, 1H), 7.31–7.62(m, 11H) IR(CHCl₃) 1517, 1475, 1371, 1227, 1219, 1176, 1117, 1081, 968, 925, 856, 821cm⁻¹ I-978 foam ¹H NMR(CDCl₃) δ 2.65(s, 3H), 2.94(s, 3H), 3.14(s, 3H), 3.59(s, 3H), 3.76(s, 3H), 5.19(s, 2H), 6.86(s, 1H), 7.16(d, J=8.7Hz, 1H), 7.33–7.57(m, 11H) IR(CHCl₃) 1517, 1477, 1398, 1370, 1268, 1233, 1216, 1177, 1159, 1079, 972, 894, 856, 818cm⁻¹ I-979 foam ¹H NMR(CDCl₃) δ 1.77(s, 3H), 1.81(s, 3H), 2.69(s, 3H), 2.94(s, 3H), 3.25(s, 3H), 3.60(s, 3H), 3.76(s, 3H), 4.64(d, J=6.9Hz, 2H), 5.50(m, 1H), 6.86(s, 1H), 7.10(d, J=8.4Hz, 1H), 7.34–7.57(m, 11H) IR(CHCl₃) 1517, 1476, 1398, 1369, 1234, 1178, 1159, 1105, 1079, 972, 895, 854, 814, 801cm⁻¹ I-980 foam ¹H NMR(CDCl₃) δ 1.76(d, J=0.9Hz, 3H), 1.81(d, J=0.9Hz, 3H), 2.71(s, 3H), 3.20(s, 3H), 3.24(s, 3H), 3.57(s, 3H), 3.79(s, 3H), 4.64(d, J=6.6Hz, 2H), 5.49(m, 1H), 6.86(s, 1H), 7.09(d, J=8.7Hz, 1H), 7.31–7.40(m, 3H), 7.48–7.55(m, 3H) IR(CHCl₃) 1517, 1474, 1365, 1269, 1236, 1177, 1140, 1116, 1078, 964, 923, 854, 814cm⁻¹ I-981 mp 122–123° C. ¹H NMR(CDCl₃) δ 1.77(s, 3H), 1.82(d, J=0.4Hz, 3H), 3.62(s, 3H), 3.75(s, 3H), 4.63(d, J=6.6Hz, 2H), 5.53(m, 1H), 5.70(s, 1H), 5.73(s, 1H), 6.46(s, 1H), 6.86(s, 1H), 6.89–7.13(m, 4H), 7.29–7.46(m, 3H) IR(KBr) 3366, 1587, 1496, 1482, 1462, 1449, 1408, 1371, 1313, 1290, 1245, 1210, 1126, 1093, 1073, 1001, 783, 770cm⁻¹

TABLE 194 I-982 mp 171–172° C. ¹H NMR(CDCl₃) δ 1.76(s, 3H), 1.82(s, 3H), 3.48(s, 3H), 3.74(s, 3H), 4.61(d, J=6.9Hz, 2H), 4.91(s, 1H), 5.53(m, 1H), 5.70(s, 1H), 5.91(s, 1H), 6.46(s, 1H), 6.86(m, 1H), 6.91–7.02(m, 2H), 7.06(m, 1H), 7.13(m, 1H), 7.21(m, 1H), 7.32(m, 1H) IR(KBr) 3368, 1585, 1519, 1507, 1484, 1460, 1450, 1403, 1294, 1255, 1237, 1206, 1110, 1072, 1006, 789, 766cm⁻¹ I-983 mp 92.5–93° C. ¹H NMR(CDCl₃) δ 1.77(s, 3H), 1.83(d, J=0.9Hz, 3H), 2.26(s, 3H), 2.27(s, 3H), 4.63(d, J=6.9Hz, 2H), 5.13(d, J=3.9Hz, 1H), 5.55(m, 1H), 6.98–7.14(m, 8H) IR(CHCl₃) 3578, 2922, 1618, 1522, 1490, 1383, 1282, 1120, 979, 873, 824cm⁻¹ I-984 mp 89–95° C. ¹H NMR(CDCl₃) δ 1.77(s, 6H), 1.81(d, J=0.9Hz, 6H), 2.27(s, 6H), 4.63(d, J=6.6Hz, 4H), 5.55(m, 2H), 6.98–7.14(m, 8H) IR(CHCl₃) 2930, 1576, 1520, 1490, 1382, 1296, 1270, 1127, 987, 874cm⁻¹ I-985 mp 74–75° C. ¹H NMR(CDCl₃) δ 2.16(s, 3H), 2.69(s, 3H), 3.14(s, 3H), 3.20(s, 3H), 3.56(s, 3H), 5.20(s, 2H), 7.16–7.49(m, 11H), 7.65–7.68 (m, 2H) IR(CHCl₃) 2939, 1732, 1613, 1518, 1478, 1454, 1415, 1371, 1331, 1292, 1268, 1176, 1150, 1118, 1088, 1010, 969, 950, 872cm⁻¹ I-986 mp 50–52° C. ¹H NMR(CDCl₃) δ 1.77(s, 3H), 1.82(s, 3H), 2.16(s, 3H), 2.74(s, 3H), 3.20(s, 3H), 3.24(s, 3H), 3.57(s, 3H), 4.64–4.66(d, J=6.3Hz, 2H), 5.50(m, 1H), 7.10–7.39(m, 6H), 7.66–7.68(m, 2H) IR(CHCl₃) 2938, 1613, 1518, 1477, 1370, 1331, 1290, 1267, 1176, 1150, 1117, 1088, 970, 949, 871cm⁻¹

TABLE 195 I-987 ¹H NMR(CDCl₃) δ 1.59–1.60(d, J=0.6Hz, 3H), 1.70–1.71(d, J=0.9Hz, 3H), 2.26(s, 3H), 2.28(s, 3H), 2.36(m, 1H), 2.77 (m, 1H), 3.20(s, 3H), 3.23(s, 3H), 5.24(m, 1H), 7.12(s, 1H), 7.15(s, 1H), 7.23–7.25(m, 1H), 7.33–7.42(m, 6H) I-988 mp 159–161° C. ¹H NMR(CDCl₃) δ 1.76(s, 3H), 1.82(s, 3H), 2.12(s, 3H), 3.48(s, 3H), 4.61–4.64(d, J=6.6Hz, 2H), 4.75(br, 1H), 5.54(m, 1H), 5.69(s, 1H), 5.73(s, 1H), 6.77–6.98(m, 6H), 7.51–7.54(m, 2H) IR(CHCl₃) 3595, 3529, 2937, 1613, 15787, 1522, 1489, 1455, 1401, 1310, 1289, 1173, 1127, 1095, 1009, 939, 835cm⁻¹ I-989 mp 126–128° C. ¹H NMR(CDCl₃) δ 2.25(s, 3H), 3.78(s, 3H), 5.16(s, 2H), 5.75(br, 1H), 6.83–6.89(m, 4H), 6.98–7.00(m, 2H), 7.17(s, 1H), 7.40–7.47(m, 7H) IR(CHCl₃) 3596, 3543, 2937, 1610, 1588, 1523, 1493, 1465, 1455, 1388, 1328, 1315, 1262, 1173, 1126, 1038, 1012, 835cm⁻¹ I-990 mp 87–90° C. ¹H NMR(CDCl₃) δ 1.59–1.60(d, J=0.6Hz, 3H), 1.72–1.73(d, J=0.9Hz, 3H), 2.26(s, 3H), 2.28(s, 3H), 2.34–2.37(m, 2H), 2.66–2.71(m, 2H), 4.84–4.86(br, 2H), 5.28(m, 1H), 6.79(d, J=1.5Hz, 1H), 6.86–6.89(m, 3H), 7.11–7.17(m, 3H), 7.23–7.26 (m, 2H) IR(CHCl₃) 3598, 2925, 2859, 1612, 1569, 1521, 1488, 1450, 1425, 1414, 1328, 1257, 1171, 1101, 958, 836cm⁻¹ I-991 mp 174–176° C. ¹H NMR(CDCl₃) δ 2.26(s, 3H), 3.13(s, 3H), 3.18(s, 3H), 3.80(s, 3H), 5.19(s, 2H), 6.84(s, 1H), 7.13(d, J=8.4Hz, 1H), 7.18(s, 1H), 7.28–7.50(m, 9H), 7.59–7.62(m, 2H) IR(CHCl₃) 2940, 1732, 1613, 1520, 1490, 1465, 1455, 1415, 1371, 1331, 1291, 1260, 1173, 1149, 1111, 1038, 1018, 1003, 971, 872, 813cm⁻¹

TABLE 196 I-992 mp 135–137° C. ¹H NMR(CDCl₃) δ 1.77–1.78(d, J=0.9Hz, 3H), 1.82–1.83(d, J=0.6Hz, 3H), 2.26(s, 3H), 3.18(s, 3H), 3.24(s, 3H), 3.80 (s, 3H), 4.64(d, J=6.6Hz, 2H), 5.52(m, 1H), 6.84(s, 1H), 7.07(d, J=8.7Hz, 1H), 7.18(s, 1H), 7.25–7.35(m, 4H), 7.59–7.62 (m, 2H) IR(CHCl₃) 3596, 3539, 2937, 1610, 1587, 1523, 1492, 1464, 1454, 1388, 1328, 1315, 1292, 1261, 1173, 1126, 1038, 996, 834cm⁻¹ I-993 mp 131–133° C. ¹H NMR(CDCl₃) δ 1.77(s, 3H), 1.83(s, 3H), 2.26(s, 3H), 3.78(s, 3H), 4.61–4.64(d, J=6.9Hz, 2H), 5.17(br, 1H), 5.35(m, 1H), 5.78(br, 1H), 6.83–6.99(m, 6H), 7.17(s, 1H), 7.44–7.47(m, 2H) IR(CHCl₃) 3596, 3539, 2937, 1610, 1587, 1523, 1492, 1464, 1454, 1388, 1328, 131, 1292, 1261, 1173, 1126, 1038, 996, 834cm⁻¹ I-994 mp 127–130° C. ¹H NMR(CDCl₃) δ 1.73(d, J=0.9Hz, 3H), 1.76(d, J=0.9Hz, 3H), 2.99(s, 6H), 3.73–3.76(m, 2H), 3.78(s, 6H), 3.88(s, 3H), 5.37–5.40(m, 1H), 5.83(d, J=7.8Hz, 1H), 6.78–6.84(m, 2H), 6.95(s, 1H), 6.96(s, 1H), 7.06–7.12(m, 2H), 7.48–7.53(m, 2H) I-995 mp 91–93° C. ¹H NMR(CDCl₃) δ 1.78(s, 3H), 1.84(s, 3H), 2.02(s, 6H), 4.63(d, J=6.4Hz, 2H), 5.07(s, 1H), 5.15(s, 1H), 5.55(t, J=7.0Hz, 1H),6.63(dd, J=2.0, 8.2Hz, 1H), 6.77(d, J=2.0Hz, 1H), 6.93–6.99(m, 4H), 7.39(d, J=8.6Hz, 2H) IR(KBr) 3423, 2921, 1611, 1518, 1474, 1282, 1244, 1205, 1125, 1089, 995, 837, 815, 785cm⁻¹ I-996 mp 185-186° C. ¹H NMR(CDCl₃) δ 1.32(t, J=7.5Hz, 3H), 2.71(q, J=7.5Hz, 2H), 3.46(s, 3H), 3.76(s, 3H), 5.15(s, 2H), 5.69(s, 1H), 5.89(s, 1H), 6.94–7.08(m, 3H), 7.37–7.46(m, 5H), 7.54–7.59(m, 2H), 7.82(brs, 1H), 7.93(d, J=8.1Hz, 1H) IR(KBr) 3504, 3269, 2968, 2936, 1708, 1532, 1518, 1487, 1311, 1286, 1193, 1121, 1071, 1014cm⁻¹

TABLE 197 I-997 mp 77–78° C. ¹H NMR(CDCl₃) δ 1.73(s, 3H), 1.77(s, 3H), 1.82(s, 3H), 2.70(s, 3H), 3.25(s, 3H), 3.55(s, 3H), 3.82(s, 3H), 4.65(d, J=6.9Hz, 2H), 4.94(d, J=7.5Hz, 2H), 5.31(t, J=8.7Hz, 1H), 5.50(t, J=6.6Hz, 1H), 6.87(s, 1H), 7.10(d, J=8.4Hz, 1H), 7.28–7.39(m, 3H), 7.87(d, J=8.1Hz, 1H), 7.99(s, 1H) IR(KBr) 3431, 2939, 1702, 1518, 1483, 1368, 1308, 1204, 1177, 1121, 1092, 1079, 957, 804cm⁻¹ I-998 mp 144–145° C. ¹H NMR(CDCl₃) δ 1.76(s, 3H), 1.82(s, 3H), 3.48(s, 3H), 3.69(s, 3H), 3.80(s, 6H), 4.61(d, J=6.9Hz, 2H), 5.51(t, J=4.8Hz, 1H), 5.66(brs, 1H), 5.76(brs, 1H), 6.30(s, 1H), 6.69(d, J=8.1Hz, 2H), 6.93–7.01(m, 2H), 7.11(d, J=2.1Hz, 1H), 7.31–7.37(m, 1H) IR(KBr) 3476, 2936, 1589, 1517, 1500, 1472, 1408, 1288, 1249, 1111cm⁻¹ I-999 mp 82–83° C. ¹H NMR(CDCl₃) δ 2.71(s, 3H), 3.15(s, 3H), 3.48(s, 3H), 3.56(s, 3H), 3.72(s, 3H), 3.80(s, 6H), 4.66(s, 2H), 4.79(s, 2H), 5.19(s, 2H), 6.69(s, 1H), 7.14–7.17(m, 1H), 7.36–7.49(m, 8H) IR(KBr) 3434, 2939, 1719, 1613, 1581, 1508, 1463, 1396, 1365, 1294, 1272, 1238, 1177, 1122, 1078, 814cm⁻¹ I-1000 mp 85–86° C. ¹H NMR(CDCl₃) δ 1.31(t, J=7.5Hz, 3H), 2.66(s, 3H), 2.71(q, J=7.6Hz, 2H), 3.13(s, 3H), 3.55(s, 3H), 3.78(s, 3H), 5.19(s, 2H), 6.85(s, 1H), 7.15(d, J=8.8Hz, 1H), 7.33–7.59(m, 4H), 7.85(brs, 1H), 7.94(d, J=8.4Hz, 1H) IR(KBr) 3432, 2939, 1727, 1519, 1480, 1365, 1237, 1165, 1079, 959, 803cm⁻¹ I-1001 mp 105–106° C. ¹H NMR(CDCl₃) δ 1.76(s, 6H), 1.79(s, 3H), 1.82(s, 3H), 3.49(s, 3H), 3.75(s, 3H), 3.81(d, J=6.6Hz, 2H), 4.62(d, J=7.2Hz, 2H), 5.37(t, J=6.3Hz, 1H), 5.53(t, J=6.9Hz, 1H), 5.68(brs, 1H), 5.87(brs, 1H), 6.82(d, J=8.4Hz, 1H), 6.95(s, 2H), 7.05(s, 1H), 7.26(s, 1H), 7.69(dd, J=2.1, 8.4Hz, 1H), 7.75(brs, 1H) IR(KBr) 3459, 2934, 1622, 1582, 1525, 1493, 1467, 1327, 1240, 1139, 1113, 1070, 817cm⁻¹

TABLE 198 I-1002 mp 89–91° C. ¹H NMR(CDCl₃) δ 2.70(s, 3H), 3.12(s, 3H), 3.55(s, 3H), 3.71(s, 3H), 3.79(s, 6H), 4.77(s, 2H), 5.18(s, 2H), 6.69(s, 2H), 7.14(d, J=8.8Hz, 1H), 7.38–7.52(m, 8H) IR(KBr) 3440, 2939, 1721, 1612, 1581, 1508, 1463, 1395, 1364, 1238, 1178, 1120, 1078, 962, 814, 523cm⁻¹ I-1003 mp 196–197° C. ¹H NMR(CDCl₃) δ 2.26(s, 3H), 3.48(s, 3H), 3.76(s, 3H), 5.16(s, 2H), 5.69(brs, 1H), 5.83(brs, 1H), 6.44(s, 1H), 6.93–7.05 (m, 4H), 7.26–7.45(m, 6H), 7.84(d, J=8.1Hz, 1H), 7.92(s, 1H), 8.29(brs, 1H) IR(KBr) 3407, 2934, 1672, 1589, 1524, 1459, 1425, 1400, 1316, 1288, 1213, 1119, 1057, 1006, 745cm⁻¹ I-1004 mp 80–81° C. ¹H NMR(CDCl₃) δ 1.29(t, J=7.5Hz, 3H), 1.72(s, 3H), 1.76(s, 6H), 1.81(s, 3H), 2.70(s, 3H), 2.71(q, J=7.5Hz, 2H), 3.24(s, 3H), 3.50(s, 3H), 3.81(s, 3H), 4.64(d, J=6.3Hz, 2H), 4.72–4.76(m, 2H), 5.31(t, J=6.9Hz, 1H), 5.50(t, J=6.3Hz, 1H), 6.87(s, 1H), 7.08–7.12(m, 2H), 7.34–7.41(m, 3H), 7.61(s, 1H) IR(KBr) 3434, 2974, 2938, 1694, 1517, 1480, 1366, 1237, 1202, 1177, 1080, 972, 807, 523cm⁻¹ I-1005 mp 157–158° C. ¹H NMR(CDCl₃) δ 1.31(t, J=7.8Hz, 3H), 1.77(s, 3H), 1.81(s, 3H), 2.71(s, 3H), 2.71(q, J=7.8Hz, 2H), 3.24(s, 3H), 3.55(s, 3H), 3.78(s, 3H), 4.64(d, J=6.6Hz, 2H), 5.50(t, J=8.1Hz, 2H), 6.85(s, 1H), 7.09(d, J=8.4Hz, 1H), 7.33–7.38(m, 2H), 7.52(d, J=8.1Hz, 1H), 7.58(s, 1H), 7.84(brs, 1H), 7.94(d, J=8.1Hz, 1H) IR(KBr) 3434, 3350, 2938, 1727, 1523, 1480, 1368, 1248, 1178, 1165, 1080, 972, 816, 802, 522cm⁻¹ I-1006 mp 91–93° C. ¹H NMR(CDCl₃) δ 1.30(t, J=7.5Hz, 3H), 1.75(s, 6H), 1.79(s, 3H), 1.81(s, 3H), 2.55(q, J=7.5Hz, 2H), 3.48(s, 3H), 3.74(s, 3H), 3.79(d, J=6.3Hz, 2H), 4.61(d, J=6.6Hz, 2H), 5.41(t, J=6.0Hz, 1H), 5.53(t, J=6.9Hz, 1H), 5.67(brs, 1H), 5.94(brs, 1H), 6.48(s, 1H), 6.72(d, J=8.4Hz, 1H), 6.95(s, 2H), 7.07(s, 1H), 7.37–7.45(m, 2H), 7.64(d, J=7.5Hz, 1H),. IR(KBr) 3433, 2932, 1609, 1521, 1489, 1461, 13958, 1308, 1286, 1245, 1192, 1114, 1072, 1011, 811cm⁻¹

TABLE 199 I-1007 mp 71–72° C. ¹H NMR(CDCl₃) δ 1.31(t, J=7.5Hz, 3H), 1.76(s, 3H), 1.82(s, 3H), 2.60(q, J=7.2Hz, 2H), 3.47(s, 3H), 3.75(s, 3H), 4.61(d, J=6.6Hz, 2H), 5.53(t, J=6.9Hz, 2H), 5.69(brs, 1H), 5.93(brs, 1H), 6.47(s, 1H), 6.78(d, J=8.1Hz, 1H), 6.95(s, 2H), 7.06(s, 1H), 7.26(s, 1H), 7.39(s, 1H) IR(KBr) 3436, 2932, 1620, 1584, 1519, 1487, 1459, 1397, 1285, 1242, 1112, 1072, 819cm⁻¹ I-1008 mp 171–173° C. ¹H NMR(CDCl₃) δ 3.46(s, 3H), 3.75(s, 3H), 5.15(s, 2H), 5.68(s, 1H), 5.88(s, 1H), 6.44(s, 1H), 6.95(dd, J=8.4, 1.9Hz, 1H), 7.03(d, J=8.4Hz, 1H), 7.08(d, J=1.9Hz, 1H), 7.37–7.48(m, 7H), 7.59(d, J=8.4Hz, 2H) IR(KBr) 3544, 3514, 3462, 1517, 1482, 1388, 1284, 1247, 1089, 1107, 1069, 1006, 938, 822cm⁻¹ I-1009 mp 180–182° C. ¹H NMR(CDCl₃) δ 2.68(s, 3H), 3.13(s, 3H), 3.53(s, 3H), 3.77(s, 3H), 5.19(s, 2H), 6.83(s, 1H), 7.15(d, J=8.4Hz, 1H), 7.32–7.49(m, 9H), 7.57(d, J=8.7Hz, 2H) IR(KBr) 1518, 1478, 1370, 1177, 1085, 1012, 813, 797cm⁻¹ I-1010 mp 128–130° C. ¹H NMR(CDCl₃) δ 1.76(s, 3H), 1.82(s, 3H), 3.46(s, 3H), 3.75(s, 3H), 4.62(d, J=7.0Hz, 2H), 5.53(t, J=7.0Hz, 1H), 5.69(s, 1H), 5.85(s, 1H), 6.44(s, 1H), 6.93(dd, J=8.4, 1.6Hz, 1H), 6.97(d, J=8.4Hz, 1H), 7.05(d, J=1.6Hz, 1H), 7.42(d, J=8.4Hz, 2H), 7.59(d, J=8.4Hz, 2H) IR(KBr) 1517, 1482, 1287, 1244, 1106, 1070, 1013, 822, 783cm⁻¹ I-1011 mp 138–140° C. ¹H NMR(CDCl₃) δ 1.76(s, 3H), 1.81(s, 3H), 2.72(s, 3H), 3.23(s, 3H), 3.54(s, 3H), 3.78(s, 3H), 4.64(d, J=6.5Hz, 2H), 5.49(t, J=6.5Hz, 1H), 6.83(s, 1H), 7.09(d, J=8.3Hz, 1H), 7.34(dd, J=8.3, 2.0Hz, 1H), 7.39(d, J=2.0Hz, 1H), 7.43(d, J=8.6Hz, 2H), 7.57(d, J=8.6Hz, 2H) IR(KBr) 1518, 1478, 1369, 1177, 1083, 972, 814, 795cm⁻¹

TABLE 200 I-1012 mp 135–138° C. ¹H NMR(CDCl₃) δ 1.55–1.63(m, 2H), 1.77(s, 6H), 1.83(s, 6H), 4.56(d, J=6.6Hz, 4H), 4.66(d, J=4.5Hz, 4H), 5.50–5.58 (m, 2H), 6.96–7.01(m, 4H), 7.32–7.38(m, 4H), 7.45(s, 2H) IR(KBr) 3339, 2914, 1609, 1520, 1488, 1385, 1289, 1238, 1177, 1000, 834, 651cm⁻¹ I-1013 mp 202–205° C. ¹H NMR(CDCl₃ + CD3OD) δ 1.78(s, 3H), 1.82(s, 3H), 4.57(d, J=6.6Hz, 2H), 4.62(s, 4H), 5.50–5.56(m, 1H), 6.86–7.00 (m, 4H), 7.24–7.37(m, 4H), 7.44(s, 2H) IR(KBr) 3399, 2974, 2930, 1610, 1522, 1489, 1438, 1383, 1238, 1176, 999, 903, 838, 538cm⁻¹ I-1014 mp 219–221° C. ¹H NMR(CDCl₃) δ 2.22(s, 3H), 2.69(s, 3H), 3.13(s, 3H), 3.53(s, 3H), 3.77(s, 3H), 5.19(s, 2H), 6.85(s, 1H), 7.15(d, J=8.4Hz, 1H), 7.32–7.49(m, 7H), 7.60(s, 4H) IR(KBr) 3384, 1701, 1604, 1524, 1482, 1355, 1294, 1176, 1084, 1011, 945, 818cm⁻¹ I-1015 mp 173–175° C. ¹H NMR(DMSO-d₆) δ 1.74(s, 3H), 1.77(s, 3H), 2.08(s, 3H), 2.87(s, 3H), 3.35(s, 3H), 3.47(s, 3H), 3.77(s, 3H), 4.68(d, J=6.4Hz, 2H), 5.48(t, J=6.4Hz, 1H), 7.02(s, 1H), 7.26–7.29(m, 3H), 7.57(d, J=8.7Hz, 2H), 7.70(d, J=8.7Hz, 2H), 10.07 (s, 1H) IR(KBr) 3383, 1704, 1235, 1524, 1481, 1360, 1177, 1083, 976, 816cm⁻¹ I-1016 mp 144–145° C. ¹H NMR(CDCl₃) δ 1.77(s, 3H), 1.81(s, 3H), 2.70(s, 3H), 3.21(s, 3H), 3.52(s, 3H), 3.69(d, J=1.6Hz, 3H), 4.65(d, J=6.8Hz, 2H), 5.53(t, J=6.8Hz, 1H), 7.08(t, J=8.4Hz, 1H), 7.16(dd, J=8.4, 1.8Hz, 1H), 7.20(dd, J=11.7, 1.8Hz, 1H), 7.41 (d, J=8.8Hz, 2H), 7.59(dd, J=8.8, 1.4Hz, 2H) IR(KBr) 1521, 1470, 1368, 1265, 1177, 1151, 1038, 971, 875cm⁻¹

TABLE 201 I-1017 mp 196–198° C. ¹H NMR(DMSO-d₆) δ 1.72(s, 3H), 1.76(s, 3H), 2.07(s, 3H), 3.31(s, 3H), 3.65(s, 3H), 4.55(d, J=6.6Hz, 2H), 5.49(t, J=6.6Hz, 1H), 6.43(s, 1H), 6.65(dd, J=8.4, 1.9Hz, 1H), 6.73(d, J=1.9Hz, 1H), 6.90(d, J=8.4Hz, 1H), 7.55(d, J=8.6Hz, 2H), 7.66(d, J=8.6Hz, 2H), 8.58(br s, 1H), 8.70(br s, 1H), 10.02(s, 1H) IR(KBr) 3358, 1661, 1596, 1523, 1489, 1396, 1308, 1254, 1227, 1114, 1074cm⁻¹ I-1018 mp 141–143° C. ¹H NMR(CDCl₃) δ 1.76(s, 3H), 1.81(s, 3H), 3.40(s, 3H), 3.64(d, J=0.9Hz, 3H), 4.64(d, J=6.9Hz, 2H), 4.89(s, 1H), 5.56(t, J=6.9Hz, 1H), 5.70(s, 1H), 6.94(d, J=8.7Hz, 2H), 7.06(t, J=8.7Hz, 1H), 7.21(ddd, J=8.4, 2.1, 1.1Hz, 1H), 7.27(dd, J=12.3, 2.1Hz, 1H), 7.44(dd, J=8.7, 1.5Hz, 2H) IR(KBr) 3485, 1523, 1466, 1402, 1266, 1173, 1036, 961, 918, 837, 814cm⁻¹ I-1019 mp 81–82° C. ¹H NMR(CDCl₃) δ 1.77(s, 3H), 1.81(s, 3H), 2.26(s, 3H), 2.72(s, 3H), 3.23(s, 3H), 3.57(s, 3H), 3.79(s, 3H), 4.64(d, J=6.3Hz, 2H), 5.49(t, J=6.3Hz, 1H), 6.83(s, 1H), 7.09(d, J=8.4Hz, 1H), 7.33–7.39(m, 2H), 7.48(s, 1H), 7.82(d, J=6.0Hz, 1H), 7.88(s, 1H), 8.32(brs, 1H) IR(KBr) 3382, 2939, 1736, 1520, 1483, 1365, 1293, 1178, 1119, 1078, 958, 802, 521cm⁻¹ I-1020 mp 93–94° C. ¹H NMR(CDCl₃) δ 2.62(s, 3H), 2.99(s, 3H), 3.15(s, 3H), 3.20(s, 3H), 3.83(s, 3H), 5.21(s, 2H), 6.91(s, 2H), 7.17(d, J=8.2Hz, 1H), 7.35–7.48(m, 8H), 7.63(d, J=8.4Hz, 2H) IR(KBr) 3434, 3033, 2938, 1611, 1520, 1479, 1366, 1179, 1151, 1085, 969, 850, 793, 519cm⁻¹

TABLE 202 I-1021 mp 74–75° C. ¹H NMR(CDCl₃) δ 1.76(s, 3H), 1.82(s, 3H), 3.48(s, 3H), 3.75(s, 3H), 4.61(d, J=6.3Hz, 2H), 5.53(t, J=5.4Hz, 1H), 5.69(brs, 1H), 5.86(brs, 1H), 6.42(s, 1H), 6.83(d, J=8.7Hz, 1H), 6.91–6.98(m, 2H), 7.04(s, 1H), 7.62(d, J=8.7Hz, 1H), 7.73(s, 1H) IR(KBr) 3495, 3398, 2935, 1633, 1522, 1487, 1291, 1246, 1112, 1072, 821, 788cm⁻¹ I-1022 mp 76–77° C. ¹H NMR(CDCl₃) δ 1.77(s, 3H), 1.82(s, 3H), 1.84(s, 3H), 3.52(s, 3H), 3.78(s, 3H), 4.63(d, J=6.9Hz, 2H), 5.53(t, J=6.6Hz, 1H), 5.74(brs, 1H), 5.80(brs, 1H), 6.47(s, 1H), 6.92–7.00(m, 2H), 7.04(s, 1H), 7.38(d, J=8.1Hz, 1H), 7.93(d, J=8.1Hz, 1H), 8.04(s, 1H) IR(KBr) 3411, 2934, 1662, 1519, 1488, 1425, 1309, 1245, 1175, 1128, 1071, 1050cm⁻¹ I-1023 mp 81–82° C. ¹H NMR(CDCl₃) δ 1.77(s, 3H), 1.81(s, 3H), 2.66(s, 3H), 2.99(s, 3H), 3.18(s, 3H), 3.25(s, 3H), 3.82(s, 3H), 4.64(d, J=6.6Hz, 2H), 5.49(t, J=6.0Hz, 1H), 6.90(s, 1H), 7.10(d, J=8.4Hz, 1H), 7.38–7.43(m, 3H), 7.62(d, J=8.8Hz, 1H), 8.02(s, 1H) IR(KBr) 3434, 3027, 2938, 1672, 1611, 1520, 1479, 1365, 1179, 1117, 1074, 970, 847, 793, 519cm⁻¹ I-1024 mp 77–79° C. ¹H NMR(CDCl₃) δ 1.78(s, 3H), 1.83(s, 3H), 3.77(s, 3H), 4.63(d, J=6.6Hz, 2H), 5.53(t, J=6.2Hz, 1H), 5.76(brs, 2H), 6.52(s, 1H), 6.91–7.02(m, 6H), 7.46(d, J=8.4Hz, 2H) IR(KBr) 3465, 2935, 1613, 1586, 1524, 1487, 1359, 1282, 1245, 1222, 1173, 1157, 1112, 1065, 974, 857, 521cm⁻¹ I-1025 mp 78–79° C. ¹H NMR(CDCl₃) δ 2.73(s, 3H), 2.78(s, 3H), 3.15(s, 3H), 3.21(s, 3H), 3.62(s, 3H), 5.22(s, 2H), 7.20(d, J=8.4Hz, 1H), 7.37–7.44(m, 10H), 7.68(d, J=8.8Hz, 2H) IR(KBr) 3433, 3032, 2939, 1519, 1473, 1366, 1178, 1151, 1004, 966, 870, 847, 795, 524cm⁻¹

TABLE 203 I-1026 mp 158–159° C. ¹H NMR(CDCl₃) δ 1.47(t, J=6.9Hz, 3H), 2.41(s, 3H), 3.21(s, 3H), 3.55(s, 3H), 3.77(s, 3H), 4.14(q, J=6.9Hz, 2H), 5.22(s, 2H), 6.83(s, 1H), 6.91(dd, J=2.1, 8.1Hz, 1H), 6.96–7.01(m, 2H), 7.28–7.48(m, 7H), 7.66–7.72(m, 2H) IR(KBr) 1517, 1482, 1392, 1362, 1240, 1194, 1175, 1146, 1084, 963, 878, 797cm⁻¹ I-1027 mp 106–107° C. ¹H NMR(CDCl₃) δ 2.27(s, 6H), 3.87(s, 3H), 5.20(s, 2H), 6.93–7.00(m, 2H), 7.01–7.17(m, 5H), 7.23–7.52(m, 7H) IR(KBr) 1607, 1522, 1490, 1467, 1455, 1383, 1294, 1267, 1246, 1178, 1125, 1028, 1011, 836, 813, 744cm⁻¹ I-108 mp 162–163° C. ¹H NMR(CDCl₃) δ 1.45(t, J=6.9Hz, 3H), 3.46(s, 3H), 3.74(s, 3H), 4.15(q, J=6.9Hz, 2H), 4.98(s, 1H), 5.19(s, 2H), 5.91(s, 1H), 6.45(s, 1H), 6.88–6.94(m, 2H), 6.95–7.03(m, 2H), 7.05(d, J=1.2Hz, 1H), 7.27–7.41(m, 3H), 7.45–7.56(m, 4H) IR(KBr) 3424, 3343, 1611, 1521, 1488, 1462, 1454, 1400, 1379, 1358, 1317, 1290, 1278, 1262, 1240, 1225, 1201, 1185, 1127, 1110, 1068, 1026, 1007, 828, 731cm⁻¹ I-1029 mp 73–74° C. ¹H NMR(CDCl₃) δ 1.77(s, 3H), 1.82(s, 3H), 2.27(s, 6H), 3.86(s, 3H), 4.63(d, J=7.2Hz, 2H), 5.56(m, 1H), 6.92–7.00(m, 2H), 7.00–7.16(m, 5H), 7.26–7.34(m, 2H) IR(KBr) 1610, 1521, 1489, 1461, 1438, 1297, 1276, 1249, 1231, 1181, 1122, 1028, 985, 835cm⁻¹ I-1030 mp 86–87° C. ¹H NMR(CDCl₃) δ 1.46(t, J=6.9Hz, 3H), 1.75(s, 3H), 1.79(d, J=0.9Hz, 3H), 2.54(s, 3H), 3.21(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 4.12(q, J=6.9Hz, 2H), 4.63(d, J=6.3Hz, 2H), 5.53(m, 1H), 6.84(s, 1H), 6.93–7.01(m, 3H), 7.35–7.41(m, 2H), 7.67–7.73(m, 2H) IR(KBr) 1518, 1480, 1449, 1413, 1389, 1366, 1239, 1199, 1180, 1150, 1082, 970, 872, 798cm⁻¹

TABLE 204 I-1031 mp 145–146° C. ¹H NMR(CDCl₃) δ 1.44(t, J=6.9Hz, 3H), 1.74(s, 3H), 1.77(d, J=0.9Hz, 3H), 3.47(s, 3H), 3.75(s, 3H), 4.13(q, J=6.9Hz, 2H), 4.63(d, J=6.6Hz, 2H), 5.10(s, 1H), 5.56(m, 1H), 5.91(s, 1H), 6.46(s, 1H), 6.89–6.94(m, 2H), 6.95–7.03(m, 3H), 7.50–7.56(m, 2H) IR(KBr) 3404, 1611, 1520, 1487, 1464, 1442, 1391, 1358, 1293, 1264, 1237, 1224, 1192, 1112, 1071, 1030, 1002, 831cm⁻¹ I-1032 mp 142–145° C. ¹H NMR(CDCl₃) δ 3.13(s, 3H), 3.21(s, 3H), 4.63(s, 2H), 4.65(s, 2H), 5.19(s, 2H), 7.15(d, J=8.4Hz, 1H), 7.33–7.52(m, 13H) IR(KBr) 3519, 3422, 3380, 3032, 2933, 1611, 1519, 1487, 1364, 1171, 1148, 1109, 969, 871, 817, 527cm⁻¹ I-1033 mp 103–106° C. ¹H NMR(CDCl₃ + CD3OD) δ 1.78(s, 3H), 1.82(s, 3H), 3.22(s, 3H), 3.24(s, 3H), 4.58–4.67(m, 6H), 5.46–5.54(m, 1H), 7.09 (d, J=8.4Hz, 1H), 7.33–7.53(m, 8H) IR(KBr) 3512, 3414, 3012, 2941, 1612, 1519, 1488, 1362, 1335, 1146, 997, 972, 876, 524cm⁻¹ I-1034 mp 184–187° C. ¹H NMR(CDCl₃ + CD3OD) δ 1.78(s, 3H), 1.82(s, 3H), 4.59–4.65(m, 6H), 5.52–5.59(m, 1H), 6.84–6.98(m, 5H), 7.23–7.28 (m, 2H), 7.44(s, 1H), 7.45(s, 1H) IR(KBr) 3400, 2931, 1611, 1521, 1491, 1247, 1203, 1009, 987, 834cm⁻¹ I-1035 mp 95–96° C. ¹H NMR(CDCl₃) δ 2.27(s, 6H), 2.41(s, 3H), 5.19(s, 2H), 7.02–7.18(m, 5H), 7.22–7.54(m, 9H) IR(KBr) 1522, 1512, 1454, 1377, 1309, 1297, 1274, 1267, 1236, 1125, 1008, 877, 822, 742, 696cm⁻¹ I-1036 mp 95–96° C. ¹H NMR(CDCl₃) δ 2.24(s, 3H), 2.27(s, 3H), 5.19(s, 2H), 6.99–7.15(m, 5H), 7.26–7.52(m, 9H) IR(KBr) 1518, 1499, 1482, 1454, 1380, 1300, 1278, 1262, 1227, 1125, 1090, 1021, 1015, 875, 834, 817, 739cm⁻¹

TABLE 205 I-1037 mp 58–59° C. ¹H NMR(CDCl₃) δ 1.77(d, J=0.6Hz, 3H), 1.81(d, J=0.9Hz, 3H), 2.27(s, 6H), 2.41(s, 3H), 4.63(d, J=6.6Hz, 2H), 5.56 (m, 1H), 6.98–7.14(m, 5H), 7.21–7.29(m, 4H) IR(KBr) 1520, 1490, 1460, 1444, 1385, 1294, 1271, 1262, 1232, 1125, 1001, 828, 818cm⁻¹ I-1038 mp 67–68° C. ¹H NMR(CDCl₃) δ 1.77(s, 3H), 1.81(d, J=0.9Hz, 3H), 2.25(s, 3H), 2.27(s, 3H), 4.64(d, J=6.6Hz, 2H), 5.55(m, 1H), 6.90–7.14(m, 5H), 7.26–7.32(m, 2H), 7.36–7.42(m, 2H) IR(KBr) 1518, 1500, 1482, 1466, 1309, 1299, 1267, 1229, 1124, 1090, 995, 834cm⁻¹ I-1039 mp 153–155° C. ¹H NMR(CDCl₃) δ 3.45(s, 3H), 3.75(s, 3H), 4.84(d, J=4.2Hz, 2H), 6.43–6.51(m, 2H), 6.45(s, 1H), 6.92(d, J=8.7Hz, 2H), 6.94–7.00(m, 2H), 7.08(brs, 1H), 7.53(d, J=8.7Hz, 2H) IR(KBr) 3411, 1612, 1588, 1523, 1489, 1288, 1245, 1224, 1113, 1070, 1011, 938, 824cm⁻¹ I-1040 foam ¹H NMR(CDCl₃) δ 3.28(d, J=2.4Hz, 1H), 3.45(s, 3H), 3.75(s, 3H), 4.94(dd, J=6.0, 1.8Hz, 2H), 5.74(ddt, J=11.1, 2.4, 1.8Hz, 1H), 6.27(dt, J=11.1, 6.0Hz, 1H), 6.45(s, 1H), 6.92(d, J=8.7Hz, 2H), 6.94–7.00(m, 2H), 7.07(d, J=2.1Hz, 1H), 7.53(d, J=8.7Hz, 2H) IR(KBr) 3433, 3279, 1612, 1588, 1523, 1489, 1286, 1248, 1223, 1113, 1070, 1011, 938, 825cm⁻¹ I-1041 foam ¹H NMR(CDCl₃) δ 3.45(s, 3H), 3.75(s, 3H), 4.90(d, J=1.8Hz, 2H), 5.55(dd, J=10.8, 2.4Hz, 1H), 5.71(dd, J=17.7, 2.4Hz, 1H), 5.85(ddt, J=17.7, 10.8, 1.8Hz, 1H), 6.45(s, 1H), 6.92(d, J=8.7Hz, 2H), 6.97(dd, J=8.4, 2.1Hz, 1H), 7.07(d, J=8.4Hz, 1H), 7.08(d, J=2.1Hz, 1H), 7.53(d, J=8.7Hz, 2H) IR(KBr) 3433, 1612, 1589, 1523, 1489, 1286, 1224, 1192, 1112, 1070, 1002, 937, 825, 815cm⁻¹

TABLE 206 I-1042 mp 185–187° C. ¹H NMR(CDCl₃) δ 1.76(s, 3H), 1.81(s, 3H), 2.76(s, 3H), 3.23(s, 3H), 3.50(s, 3H), 3.78(s, 3H), 4.64(d, J=6.6Hz, 2H), 5.50(t, J=6.6Hz, 1H), 6.63(t, J=2.4Hz, 1H), 6.95(s, 1H), 7.09(d, J=8.5Hz, 1H), 7.26–7.29(m, 1H), 7.37(dd, J=8.5, 2.1Hz, 1H), 7.42(d, J=2.1Hz, 1H), 7.45–7.51(m, 2H), 7.89(s, 1H), 8.26(br s, 1H) IR(KBr) 3418, 1473, 1362, 1177, 1079, 961, 817, 796cm⁻¹ I-1043 mp 152–154° C. ¹H NMR(CDCl₃) δ 1.76(s, 3H), 1.82(s, 3H), 3.43(s, 3H), 3.76(s, 3H), 4.61(d, J=6.9Hz, 2H), 5.53(t, J=6.9Hz, 1H), 5.69(s, 1H), 5.98(s, 1H), 6.55(s, 1H), 6.63(t, J=2.1Hz, 1H), 6.94–7.01(m, 2H), 7.10(d, J=0.9Hz, 1H), 7.25–7.27(m, 1H), 7.46(d, J=8.4Hz, 1H), 7.51(dd, J=8.5, 1.5Hz, 1H), 7.89(s, 1H), 8.24(br s, 1H) IR(CHCl₃) 3529, 3480, 1515, 1495, 1407, 1291, 1246, 1107, 1070cm⁻¹ I-104 mp 127–128° C. ¹H NMR(CDCl₃) δ 2.45(s, 3H), 3.52(s, 3H), 3.77(s, 3H), 3.91(s, 3H), 5.22(s, 2H), 6.84(s, 1H), 6.91(dd, J=8.4, 2.1Hz, 1H), 6.79–7.00(m, 2H), 7.12–7.18(m, 2H), 7.30–7.47(m, 5H), 7.59–7.63(m, 2H) IR(CHCl₃) 2938, 2843, 1606, 1585, 1520, 1483, 1464, 1443, 1390, 1368, 1174, 1141, 1083, 1013, 962, 936, 865, 838cm⁻¹ I-1045 mp 124–127° C. ¹H NMR(CDCl₃) δ 2.46(s, 3H), 3.55(s, 3H), 3.77(s, 3H), 3.91(s, 3H), 5.21(s, 2H), 5.42(br, 1H), 6.82(s, 1H), 6.90(dd, J=8.4, 1.8Hz, 1H), 6.97–7.10(m, 3H), 7.29–7.47(m, 7H) IR(CHCl₃) 3579, 2938, 1600, 1523, 1484, 1464, 1393, 1368, 1327, 1282, 1174, 1141, 1081, 1036, 1012, 962, 908cm⁻¹ I-1046 mp 178–180° C. ¹H NMR(CDCl₃) δ 2.44(s, 3H), 3.29(s, 3H), 3.58(s, 3H), 3.78(s, 3H), 3.91(s, 3H), 5.22(s, 2H), 6.83(s, 1H), 6.99(dd, J=8.1, 2.1Hz, 1H), 6.97–7.25(m, 2H), 7.31–7.58(m, 8H) IR(CHCl₃) 2939, 2840, 1591, 1519, 1483, 1464, 1374, 1331, 1173, 1141, 1116, 1082, 1012, 964, 863cm⁻¹

TABLE 207 I-107 mp 98–99° C. ¹H NMR(CDCl₃) δ 2.35(s, 3H), 5.22(s, 2H), 6.59(t, J F-H=54.6Hz, 2H), 7.09–7.50(m, 12H), 7.74–7.75(d, J=4.5Hz, 2H) IR(CHCl₃) 1752, 1523, 1493, 1384, 1273, 1169, 1133, 1070, 1037, 916, 851cm⁻¹ I-1048 mp 112–114° C. ¹H NMR(CDCl₃) δ 1.75–1.76(d, J=0.6Hz, 3H), 1.78–1.79(d, J=0.9Hz, 3H), 2.57(s, 3H), 3.53(s, 3H), 3.78(s, 3H), 3.89 (s, 3H), 4.62–4.64(d, J=7.5Hz, 2H), 5.54(s, 1H), 6.84(s, 1H), 6.96–6.97(m, 3H), 7.12–7.18(m, 2H), 7.59–7.64(m, 2H) IR(CHCl₃) 2938, 1606, 1583, 1519, 1483, 1464, 1443, 1416, 1389, 1368, 1175, 1141, 1083, 1038, 1013, 962, 936, 865, 838cm⁻¹ I-1049 mp 203–204° C. ¹H NMR(CD3OD) δ 4.53(s, 2H), 4.55(s, 2H), 5.21(s, 2H), 6.84–6.88(m, 2H), 7.12–7.50(m, 12H) IR(KBr) 3380, 1611, 1586, 1523, 1490, 1462, 1434, 1380, 1317, 1300, 1258, 1194, 1173, 1128, 1033, 1007, 906, 871, 836, 817, 787, 730, 693, 646cm⁻¹ I-1050 mp 99–100° C. ¹H NMR(CDCl₃) δ 1.75(s, 3H), 1.78–1.79(d, J=0.9Hz, 3H), 3.46(s, 3H), 3.75(s, 3H), 3.88(s, 3H), 4.62–4.64(d, J=6.6Hz, 2H), 5.57(m, 1H), 5.89(s, 1H), 6.46(s, 1H), 6.96–7.02(m, 3H), 7.12–7.18(m, 2H), 7.59–7.64(m, 2H) IR(CHCl₃) 3513, 2938, 1605, 1583, 1490, 1423, 1407, 1392, 1362, 1318, 1269, 1177, 1158, 1140, 1118, 1078, 1038, 1012, 930, 846, 826cm⁻¹ I-1051 mp 153–154° C. ¹H NMR(CDCl₃) δ 1.76(s, 3H), 1.79–1.80(d, J=0.9Hz, 3H), 2.57(s, 3H), 3.29(s, 3H), 3.60(s, 3H), 3.79(s, 3H), 3.89(s, 3H), 4.62–4.64(d, J=6.6Hz, 2H), 5.54(m, 1H), 6.84(s, 1H), 6.96–6.97(m, 4H), 7.46–7.59(m, 3H) IR(CHCl₃) 2938, 1592, 1519, 1483, 1464,. 1374, 1332, 1239, 1173, 1141, 1116, 1082, 1038, 1011, 965, 864cm⁻¹

TABLE 208 I-1052 amorphous ¹H NMR(CDCl₃) δ 2.12(s, 3H), 3.47(s, 3H), 5.15(s, 2H), 5.82–6.08(m, 3H), 6.70–6.95(m, 5H), 7.02(d, J=8.1Hz, 1H), 7.39–7.52(m, 7H) IR(CHCl₃) 3597, 3535, 2937, 1731, 1612, 1589, 1522, 1489, 1455, 1401, 1382, 1328, 1309, 1288, 1173, 1128, 1096, 1011, 939, 835cm⁻¹ I-1053 mp 141–142° C. ¹H NMR(CDCl₃) δ 1.75(s, 3H), 1.78–1.79(d, J=0.9Hz, 3H), 3.49(s, 3H), 3.76(s, 3H), 3.89(s, 3H), 4.62–4.64(d, J=6.6Hz, 2H), 5.30(d, J F-H=3.3Hz, 1H), 5.57(m, 1H), 5.88(s, 1H), 6.45(s, 1H), 6.99–7.11(m, 4H), 7.33(m, 1H), 7.43(dd, J=11.7, 2.1Hz, 1H) IR(CHCl₃) 3578, 3514, 1621, 1600, 1583, 1523, 1492, 1464, 1397, 1320, 1279, 1175, 1140, 1116, 1100, 1076, 1038, 1011, 902cm⁻¹ I-1054 mp 138–140° C. ¹H NMR(CDCl₃) δ 5.17(s, 2H), 5.60(s, 1H), 5.72(s, 1H), 6.98–7.02(m, 2H), 7.10–7.14(m, 3H), 7.18(s, 1H), 7.35(s, 1H), 7.37–7.47(m, 5H), 7.59–7.61(m, 2H) IR(KBr) 3600–2800(br), 1590, 1528, 1503, 1483, 1454, 1386, 1294, 1254, 1223, 1187, 1132, 1086, 1009cm⁻¹ I-1055 mp 176–178° C. ¹H NMR(CDCl₃) δ 3.13(s, 3H), 3.32(s, 3H), 5.19(s, 2H), 7.16(d, J=8.7Hz, 1H), 7.37–7.55(m, 9H), 7.61–7.64(m, 4H) IR(KBr) 3600–2800(br), 1611, 1525, 1503, 1469, 1359, 1290, 1244, 1170, 1088, 979cm⁻¹ I-1056 mp 134–136° C. ¹H NMR(CDCl₃) δ 1.77(s, 3H), 1.81(s, 3H), 3.23(s, 3H), 3.32(s, 3H), 4.64(d, J=6.9Hz, 1H), 5.48–5.54(m, 1H), 7.10(d, J=8.4Hz, 1H), 7.44–7.55(m, 4H), 7.58–7.65(m, 4H) IR(KBr) 3600–2800(br), 1609, 1527, 1504, 1469, 1351, 1289, 1277, 1186, 1171, 1115, 1089, 973cm⁻¹

TABLE 209 I-1057 mp 97–100° C. ¹H NMR(CDCl₃) δ 1.77(d, J=0.9Hz, 3H), 1.82(d, J=0.9Hz, 3H), 4.63(d, J=7.2Hz, 2H), 5.50–5.54(m, 1H), 5.62(br s, 1H), 5.74(br s, 1H), 6.95(d, J=8.7Hz, 1H), 7.12(dd, J=2.4, 8.7Hz, 1H), 7.18(s 1H), 7.24(d, J=2.4Hz, 1H), 7.36(s, 1H), 7.42–7.46(m, 2H), 7.58–7.62(m, 2H) IR(KBr) 3600–2800(br), 1599, 1588, 1528, 1482, 1385, 1326, 1289, 1252, 1212, 1193, 1132, 1112, 1084, 1056, 1001cm⁻¹ I-1058 mp 216–218° C. ¹H NMR(DMSO-d₆) δ 2.93(s, 12H), 3.73(s, 6H), 6.74–6.79(m, 4H), 6.92(s, 2H), 7.38–7.43(m, 4H) IR(KBr) 3600–2800(br), 1616, 1533, 1496, 1458, 1442, 1387, 1360, 1230, 1202, 1169, 1059, 1035cm⁻¹ I-1059 mp 122–123° C. ¹H NMR(CDCl₃) δ 1.74(d, J=0.6Hz, 3H), 1.78(d, J=0.6Hz, 3H), 2.26(s, 3H), 2.29(s, 3H), 3.77(d, J=6.9Hz, 2H), 4.83(br, 1H), 5.36–5.41(m, 1H), 6.61–6.77(m, 1H), 6.86–6.91(m, 2H), 6.99–7.04(m, 2H), 7.10(s, 1H), 7.11(s, 1H), 7.21–7.26 (m, 2H) IR(KBr) 3600–2800(br), 1626, 1608, 1526, 1489, 1428, 1336, 1300, 1252, 1209, 1187cm⁻¹ I-1060 mp foam ¹H NMR(CDCl₃) δ 1.74(s, 3H), 1.77(s, 3H), 2.27(s, 3H), 2.31(s, 3H), 3.76(d, J=6.6Hz, 2H), 3.86(s, 3H), 5.38–5.43(m, 1H), 6.66(d, J=8.1Hz, 1H), 6.80(d, J=1.8Hz, 1H), 6.86–6.90(m, 3H), 7.11(s, 1H), 7.16(s, 1H), 7.23–7.26(m, 2H) IR(CHCl₃) 3600–2800(br), 1730, 1611, 1525, 1489, 1455, 1256, 1171, 1137, 1100, 1036cm⁻¹ I-1061 mp 191–193° C. ¹H NMR(CDCl₃) δ 3.01(s, 6H), 3.79(s, 3H), 3.80(s, 3H), 6.79–6.83(m, 2H), 6.92(s, 1H), 6.98(s, 1H), 7.41–7.51(m, 4H), 8.12(br s, 1H), 8.26–8.32(m, 1H) IR(KBr) 3600–2800(br), 1712, 1617, 1600, 1536, 1494, 1460, 1446, 1385, 1364, 1290, 1212, 1162, 1057, 1035cm⁻¹

TABLE 210 I-1062 mp 240–245° C. ¹H NMR(CDCl₃) δ 3.82(s, 6H), 6.95(s, 2H), 7.41–7.49(m, 4H), 8.13(br s, 2H), 8.29–8.35(m, 1H) IR(KBr)3600–2800(br), 1725, 1598, 1544, 1492, 1381, 1294, 1215, 1197, 1165, 1109, 1055, 1033cm⁻¹ I-1063 ¹H NMR(CDCl₃) δ 1.99(s, 6H), 2.17(s, 3H), 3.21(s, 3H), 5.20(s, 2H), 6.95–7.11(m, 4H), 7.23(d, J=8.7Hz, 2H), 7.33–7.52 (m, 7H) IR(KBr)1617, 1577, 1513, 1366, 1295, 1267, 1198, 1173, 1149, 1127, 1106cm⁻¹ I-1064 ¹H NMR(CDCl₃) δ 1.99(s, 6H), 2.17(s, 3H), 3.21(s, 3H), 5.18(d, J=3.9Hz, 1H), 6.97–7.10(m, 4H), 7.23(d, J=8.7Hz, 2H), 7.37(d, J=8.7Hz, 2H) IR(KBr)3442, 1620, 1597, 1519, 1472, 1356, 1279, 1232, 1174, 1147, 1103cm⁻¹ I-1065 ¹H NMR(CDCl₃) δ 1.78(s, 3H), 1.83(s, 3H), 2.00(s, 6H), 2.19(s, 3H), 3.22(s, 3H), 4.65(d, J=6.3Hz, 2H), 5.52–5.62(m, 1H), 6.96–7.13(m, 4H), 7.24(d, J=8.7Hz, 2H), 7.38(d, J=8.7Hz, 2H) IR(KBr)1617, 1576, 1514, 1466, 1359, 1297, 1268, 1204, 1151, 1002cm⁻¹ I-1066 ¹H NMR(CDCl₃) δ 1.77(s, 3H), 1.81(s, 3H), 2.01(s, 6H), 2.18(s, 3H), 4.63(d, J=6.9Hz, 2H), 4.75(s, 1H), 5.52–5.60(m, 1H), 6.82–7.11(m, 8H) IR(KBr)3433, 1606, 1517, 1466, 1297, 1269, 1221, 1128, 1107, 1004cm⁻¹ I-1067 ¹H NMR(CDCl₃) δ: 2.25(s, 3H), 2.27(s, 3H), 2.31(s, 3H), 3.20(s, 3H), 4.75(s, 1H), 6.83(d, J=8.4Hz, 1H), 7.05–7.14 (m, 4H), 7.34(d, J=8.4Hz, 2H), 7.42(d, J=8.4Hz, 2H) IR(KBr)3494, 3435, 1604, 1517, 1488, 1375, 1327, 1199, 1171, 1148, 1118cm⁻¹ I-1068 ¹H NMR(CDCl₃) δ 1.77(s, 3H), 1.82(s, 3H), 2.25(s, 3H), 2.28(s, 6H), 3.20(s, 3H), 4.58(d, J=6.6Hz, 2H), 5.50–5.58 (m, 1H), 6.88(d, J=9.0Hz, 1H), 7.08–7.16(m, 4H), 7.34(.d, J=8.7Hz, 2H), 742(d, J=8.7Hz, 2H) IR(KBr)1604, 1513, 1486, 1367, 1238, 1176, 1153, 1131, 1002cm⁻¹

TABLE 211 I-1069 ¹H NMR(CDCl₃) δ 1.76(s, 3H), 1.81(s, 3H), 2.26(s, 3H), 2.28(s, 6H), 4.57(d, J=6.6Hz, 2H), 4.80(s, 1H), 5.50–5.58 (m, 1H), 6.85–6.91(m, 3H), 7.09–7.17(m, 3H), 7.21–7.28(m, 3H) IR(KBr)3436, 1608, 1518, 1488, 1238, 1130, 1008cm⁻¹ I-1070 ¹H NMR(CDCl₃) δ: 2.26(s, 3H), 2.30(s, 3H), 3.00(s, 6H), 5.19(s, 2H), 6.80(.d, J=8.7Hz, 2H), 7.02–7.16(m, 5H), 7.26 (d, J=8.7Hz, 2H), 7.33–7.51(m, 5H) IR(KBr)1608, 1527, 1490, 1355, 1297, 1270, 1262, 1231, 1121, 1022cm⁻¹ I-1071 ¹H NMR(CDCl₃) δ 2.26(s, 3H), 2.30(s, 3H), 3.01(s, 6H), 5.09(s, 1H), 6.80(d, J=8.4Hz, 2H), 7.01–7.15(m, 5H), 7.27(.d, J=8.4Hz, 2H) IR(KBr)3432, 1613, 1590, 1526, 1489, 1307, 1283, 1241, 1138, 1111cm⁻¹ I-1072 ¹H NMR(CDCl₃) δ: 1.77(s, 3H), 1.81(s, 3H), 2.27(s, 3H), 2.30(s, 3H), 3.00(s, 6H), 4.63(d, J=6.6Hz, 2H), 5.51–5.59(m, 1H), 6.80(d, J=8.4Hz, 2H), 6.97–7.16(m, 5H), 7.27(d, J=8.14Hz, 2H) IR(KBr)1611, 1528, 1489, 1353, 1297, 1266, 1228, 1122, 1011cm⁻¹ I-1073 mp 182–184° C. ¹H NMR(CDCl₃) δ 1.48(s, 3H), 1.67(s, 3H), 1.91(s, 3H), 3.46(s, 3H), 3.76(s, 3H), 3.84(s, 3H), 3.94–4.03(m, 1H), 4.05–4.59 (m, 1H), 5.23–5.32(m, 1H), 5.74(br s, 1H), 6.05(s, 1H), 6.48(s, 1H), 6.93–6.99(m, 2H), 7.04–7.10(m, 3H), 7.51–7.56(m, 3H) IR(KBr)3400, 2934, 1625, 1523, 1396, 1227, 1119, 1077, 1036, 826, 589cm⁻¹ I-1074 mp 153–154° C. ¹H NMR(CDCl₃) δ 1.74(s, 3H), 1.78(s, 3H), 2.30(s, 3H), 2.31(s, 3H), 3.75(d, J=6.6Hz, 2H), 3.86(s, 3H), 3.87(s, 3H), 5.37–5.45(m, 1H), 6.66(d, J=8.4Hz, 1H), 6.74–6.83(m, 5H), 6.89(dd, J=1.8, 8.1Hz, 1H), 7.14(s, 1H), 7.16(s, 1H) IR(KBr)3408, 3389, 3294, 3210, 2919, 2835, 1528, 1495, 1275, 1208, 1032, 856, 826cm⁻¹

TABLE 212 I-1075 mp 168–171° C. ¹H NMR(CDCl₃) δ 1.74(s, 6H), 1.77(s, 6H), 2.31(s, 6H), 3.75(d, J=6.9Hz, 4H), 3.86(s, 6H), 5.37–5.45(m, 2H), 6.66(d, J=8.1Hz, 2H), 6.80(d, J=1.8Hz, 2H), 6.89(dd, J=1.8, 8.1Hz, 2H), 7.16(s, 1H) IR(KBr)3423, 2968, 2927, 2912, 2849, 1609, 1526, 1498, 1454, 1261, 1209, 1135, 1030, 855, 803cm⁻¹ I-1076 mp 79–80° C. ¹H NMR(CDCl₃) δ 2.54(s, 3H), 3.19(s, 3H), 3.85(s, 3H), 5.17(s, 2H), 5.71(brs, 1H), 6.93(d, J=8.1Hz, 1H), 7.01–7.07 (m, 3H), 7.24–7.26(m, 2H), 7.37–7.43(m, 7H), 7.66(d, J=8.7Hz, 2H) IR(KBr)3466, 3029, 2939, 2937, 1610, 1520, 1482, 1365, 1246, 1201, 1175, 1150, 1073, 969, 872, 839, 804cm⁻¹ I-1077 mp 151–152° C. ¹H NMR(CDCl₃) δ 4.00(s, 3H), 4.91(brs, 1H), 5.24(s, 2H), 6.89(d, J=8.2Hz, 2H), 7.00(d, J=8.0Hz, 1H), 7.12–7.47(m, 10H), 7.71(d, J=7.4Hz, 1H), 7.89(s, 1H) IR(KBr)3422, 1612, 1526, 1491, 1454, 1329, 1287, 1269, 1248, 1171, 1136, 1103, 1019, 827cm⁻¹ I-1078 mp 173–174° C. ¹H NMR(CDCl₃) δ 3.13(s, 3H), 4.92(brs, 1H), 5.19(s, 2H), 6.88(d, J=8.6Hz, 2H), 7.15–7.26(m, 4H), 7.35–7.59(m, 7H), 7.69(d, J=9.4Hz, 1H), 7.86(s, 1H) IR(KBr)3426, 1613, 1527, 1489, 1435, 1361, 1330, 1294, 1243, 1164, 1118, 1070, 978, 821cm⁻¹ I-1079 mp 168–169° C. ¹H NMR(CDCl₃) δ 3.20(s, 3H), 3.99(s, 3H), 5.22(s, 2H), 6.89(d, J=8.8Hz, 1H), 7.11–7.15(m, 2H), 7.31–7.49(m, 10H), 7.73(d, J=7.4Hz, 1H), 7.90(s, 1H) IR(KBr)3434, 1603, 1524, 1488, 1369, 1335, 1244, 1178, 1143, 1119, 1006, 871cm⁻¹

TABLE 213 I-1080 mp 68–69° C. ¹H NMR(CDCl₃) δ 3.13(s, 3H), 3.19(s, 3H), 5.19(s, 2H), 7.18(d, J=8.6Hz, 2H), 7.26–7.59(m, 11H), 7.73(d, J=9.2Hz, 1H), 7.89(s, 1H) IR(KBr)3431, 3034, 2938, 1613, 1524, 1487, 1367, 1330, 1293, 1242, 1175, 1151, 1118, 970, 872, 828cm⁻¹ I-1081 mp 74–76° C. ¹H NMR(CDCl₃) δ 1.78(s, 3H), 1.84(s, 3H), 3.51(s, 3H), 4.64(d, J=5.6Hz, 2H), 5.08(brs, 2H), 5.49–5.54(m, 1H), 5.75 (brs, 1H), 5.85(brs, 1H), 6.14(s, 1H), 6.89–7.12(m, 5H), 7.53(d, J=8.4Hz, 2H) IR(KBr)3444, 2934, 1612, 1523, 1485, 1403, 1360, 1251, 1172, 1006, 971, 837, 527cm⁻¹ I-1082 mp 71–72° C. ¹H NMR(CDCl₃) δ 2.46(s, 3H), 3.20(s, 3H), 3.86(s, 3H), 3.91(s, 3H), 5.21(s, 2H), 6.87–7.03(m, 3H), 7.11(s, 1H), 7.24–7.41 (m, 8H), 7.67(d, J=8.8Hz, 2H) IR(KBr)3434, 3028, 2936, 1609, 1521, 1482, 1365, 1239, 1176, 1074, 969, 869, 804cm⁻¹ I-1083 mp 73–74° C. ¹H NMR(CDCl₃) δ 2.66(s, 3H), 3.13(s, 3H), 3.20(s, 3H), 3.86(s, 3H), 5.19(s, 2H), 7.08(d, J=1.6Hz, 1H), 7.16(d, J=8.4Hz, 1H), 7.21–7.28(m, 2H), 7.37–7.42(m, 8H), 7.66(d, J=8.4Hz, 2H) IR(KBr)3432, 3031, 2938, 1610, 1523, 1480, 1365, 1176, 1151, 1074, 970, 875, 807, 524cm⁻¹ I-1084 mp 110–111° C. ¹H NMR(CDCl₃) δ 1.78(s, 3H), 1.81(s, 3H), 3.21(s, 3H), 3.98(s, 3H), 4.67(d, J=6.6Hz, 2H), 5.57(t, J=6.8Hz, 1H), 7.01(d, J=8.0Hz, 1H), 7.15–7.21(m, 2H), 7.28–7.45(m, 4H), 7.76(d, J=7.6Hz, 1H), 7.93(s, 1H), 8.03(s, 1H) IR(KBr)3434, 3010, 2931, 1524, 1488, 1368, 1336, 1247, 1173, 1149, 1121, 1007, 871, 562cm⁻¹

TABLE 214 I-1085 mp 147–148° C. ¹H NMR(CDCl₃) δ 1.76(s, 3H), 1.79(s, 3H), 3.96(s, 3H), 4.65(d, J=6.3Hz, 2H), 4.91(brs, 1H), 5.55(t, J=5.7Hz, 1H), 6.88(d, J=8.1Hz, 2H), 6.99(d, J=8.4Hz, 1H), 7.12–7.26(m, 4H), 7.36(d, J=8.1Hz, 1H), 7.89(s, 1H) IR(KBr)3450, 2938, 1612, 1524, 1490, 1436, 1340, 1264, 1230, 1212, 1139, 1123, 984, 835cm⁻¹ I-1086 mp 134–135° C. ¹H NMR(CDCl₃) δ 1.77(s, 3H), 1.82(s, 3H), 4.64(d, J=6.6Hz, 2H), 4.84(brs, 1H), 5.52(t, J=7.2Hz, 1H), 5.77(s, 1H), 6.87(d, J=8.7Hz, 2H), 6.96(d, J=8.4Hz, 1H), 7.12(dd, J=2.4, 8.7Hz, 1H), 7.35(d, J=8.1Hz, 1H), 7.70(d, J=8.4Hz, 1H), 7.89(s, 1H) IR(KBr)3367, 1610, 1489, 1442, 1333, 1265, 1193, 1165, 1124, 834, 805cm⁻¹ I-1087 mp 156–157° C. ¹H NMR(CDCl₃) δ 1.78(s, 3H), 1.81(s, 3H), 3.82(s, 3H), 3.89(s, 3H), 4.65(d, J=6.2Hz, 2H), 4.95(brs, 1H), 5.22(brs, 1H), 5.58(t, J=6.0Hz, 1H), 6.73(s, 1H), 6.87–7.00(m, 6H), 7.53(d, J=8.4Hz, 2H) IR(KBr)3394, 2934, 1610, 1526, 1499, 1455, 1402, 1240, 1221, 1139, 1099, 894, 815cm⁻¹ I-1088 mp 69–70° C. ¹H NMR(CDCl₃) δ 1.77(s, 3H), 1.83(s, 3H), 3.80(s, 3H), 4.63(d, J=7.0Hz, 2H), 4.93(brs, 1H), 5.22(brs, 1H), 5.52(t, J=7.0Hz, 1H), 5.78(brs, 1H), 6.70(d, J=1.6Hz, 1H), 6.83–7.01(m, 6H), 7.51(d, J=8.8Hz, 2H) IR(KBr)3411, 2933, 1611, 1526, 1492, 1453, 1263, 1242, 1220, 1190, 1172, 1096, 907, 822cm⁻¹ I-1089 mp 160–161° C. ¹H NMR(CDCl₃) δ 1.39(d, J=6.0Hz, 6H), 2.40(s, 3H), 3.21(s, 3H), 3.55(s, 3H), 3.77(s, 3H), 4.55(m, 1H), 5.20(s, 2H), 6.83(s, 1H), 6.93(dd, J=1.8, 8.1Hz, 1H), 7.01(d, J=8.1Hz, 1H), 7.01(d, J=1.8Hz, 1H), 7.28–7.48(m, 7H), 7.66–7.72(m, 2H) IR(KBr)1515, 1480, 1463, 1391, 1363, 1239, 1192, 1176, 1149, 1082, 1018, 962, 873, 800cm⁻¹

TABLE 215 I-1090 mp 154–155° C. ¹H NMR(CDCl₃) δ 2.59(s, 3H), 3.21(s, 3H), 3.54(s, 3H), 3.77(s, 3H), 5.23(s, 2H), 6.84(s, 1H), 7.06(d, J=8.4Hz, 1H), 7.24–7.50(m, 9H), 7.65–7.71(m, 2H) IR(KBr)1513, 1479, 1365, 1267, 1232, 1178, 1150, 1079, 971, 959, 875, 797cm⁻¹ I-1091 mp 137–138° C. ¹H NMR(CDCl₃) δ 1.38(d, J=6.3Hz, 6H), 3.46(s, 3H), 3.74(s, 3H), 4.54(m, 1H), 4.96(s, 1H), 5.17(s, 2H), 5.92(s, 1H), 6.45(s, 1H), 6.89–6.94(m, 2H), 7.00–7.11(m, 3H), 7.27–7.41(m, 3H), 7.45–7.56(m, 4H) IR(KBr)3443, 3356, 1611, 1521, 1488, 1458, 1393, 1269, 1236, 1138, 1112, 1074, 1013, 830, 743cm⁻¹ I-1092 mp 75–76° C. ¹H NMR(CDCl₃) δ 1.37(d, J=5.8Hz, 6H), 1.75(s, 3H), 1.79(s, 3H), 2.53(s, 3H), 3.21(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 4.51(m, 1H), 4.61(d, J=6.6Hz, 2H), 5.52(m, 1H), 6.84(s, 1H), 6.96–7.02(m, 3H), 7.34–7.42(m, 2H), 7.65–7.74(m, 2H) IR(KBr)1516, 1480, 1449, 1360, 1332, 1240, 1199, 1177, 1152, 1083, 964, 873, 797cm⁻¹ I-1093 mp 119–120° C. ¹H NMR(CDCl₃) δ 1.37(d, J=6.3Hz, 6H), 1.73(s, 3H), 1.77(d, J=0.9Hz, 3H), 3.46(s, 3H), 3.75(s, 3H), 4.51(m, 1H), 4.61(d, J=6.6Hz, 2H), 5.14(s, 1H), 5.54(m, 1H), 5.93(s, 1H), 6.46(s, 1H), 6.89–6.95(m, 2H), 6.98(d, J=8.1Hz, 1H), 7.01–7.07(m, 2H), 7.50–7.56(m, 2H) IR(KBr)3426, 1610, 1522, 1488, 1455, 1402, 1267, 1237, 1174, 1135, 1112, 1079, 1020cm⁻¹ I-1094 mp 150–151° C. ¹H NMR(CDCl₃) δ 3.44(s, 3H), 3.75(s, 3H), 4.90(s, 1H), 5.20(s, 2H), 5.99(s, 1H), 6.44(s, 1H), 6.88–6.95(m, 2H), 7.04(d, J=8.4Hz, 1H), 7.29–7.44(m, 4H), 7.47–7.56(m, 5H) IR(KBr)3410, 1610, 1519, 1484, 1463, 1455, 1410, 1382, 1359, 1285, 1264, 1229, 1118, 1074, 1060, 1014, 995cm⁻¹ I-1095 ¹H NMR(CDCl₃) δ 0.96(s, 3H), 0.98(s, 3H), 1.53–1.82(m, 3H), 2.99(s, 6H), 3.20(t, J=7.2Hz, 2H), 3.78(s, 3H), 3.79(s, 3H), 3.87(br, 1H), 6.71–6.83(m, 3H), 6.92(s, 1H), 6.94(s, 1H), 7.23–7.31(m, 2H), 7.47–7.52(m, 2H)

TABLE 216 I-1096 mp 87–89° C. ¹H NMR(CDCl₃) δ 1.70(s, 3H), 1.75(s, 3H), 2.82(s, 3H), 3.00(s, 3H), 3.74–3.80(m, 2H), 3.78(s, 3H), 3.80(s, 3H), 5.29–5.34 (m, 1H), 6.79–6.83(m, 2H), 6.92–6.97(m, 3H), 7.25–7.34(m, 2H), 7.47–7.52(m, 2H) IR(KBr)3600–2800(br), 1613, 1531, 1495, 1460, 1448, 1380, 1359, 1253, 1210, 1057, 1036cm⁻¹ I-1097 mp 167–169° C. ¹H NMR(CDCl₃) δ 2.92(s, 3H), 3.00(s, 6H), 3.78(s, 3H), 3.79(s, 3H), 4.02(br, 1H), 6.71–6.83(m, 3H), 6.92(s, 1H), 6.95 (s, 1H), 7.25–7.32(m, 2H), 7.47–7.52(m, 2H) IR(KBr)3600–2800(br), 1625, 1613, 1533, 1497, 1462, 1445, 1381, 1358, 1328, 1262, 1205, 1163, 1051, 1031cm⁻¹ I-1098 mp 114–115° C. ¹H NMR(CDCl₃) δ 2.27(s, 6H), 2.54(s, 3H), 5.19(s, 2H), 7.00–7.16(m, 5H), 7.26–7.51(m, 9H) IR(KBr)1519, 1501, 1483, 1454, 1310, 1295, 1263, 1232, 1123, 998, 744cm⁻¹ I-1099 mp 68–69° C. ¹H NMR(CDCl₃) δ 1.62(br s, 1H), 1.77(s, 3H), 1.82(s, 3H), 2.27(s, 3H), 2.28(s, 3H), 4.64(d, J=6.8Hz, 2H), 4.76(s, 2H), 5.56(m, 1H), 7.00–7.16(m, 5H), 7.33–7.48(m, 4H) IR(KBr)3433, 1522, 1490, 1384, 1311, 1296, 1266, 1232, 1194, 1122, 1025, 1013, 992, 841, 818cm⁻¹ I-1100 mp 68–69° C. ¹H NMR(CDCl₃) δ 1.62(br s, 1H), 1.77(s, 3H), 1.82(s, 3H), 2.27(s, 3H), 2.28(s, 3H), 4.64(d, J=6.8Hz, 2H), 4.76(s, 2H), 5.56(m, 1H), 7.00–7.16(m, 5H), 7.33–7.48(m, 4H) IR(KBr)3433, 1522, 1490, 1384, 1311, 1296, 1266, 1232, 1194, 1122, 1025, 1013, 992, 841, 818cm⁻¹

TABLE 217 I-1101 mp 171° C. ¹H NMR(CDCl₃) δ 1.77(s, 3H), 1.81(d, J=0.9Hz, 3H), 2.68(s, 3H), 3.21(s, 3H), 3.55(s, 3H), 3.78(s, 3H), 4.65(d, J=6.6Hz, 2H), 5.53(m, 1H), 6.84(s, 1H), 7.03(d, J=8.7Hz, 1H), 7.29(dd, J=2.1, 8.7Hz, 1H), 7.36–7.41(m, 2H), 7.46(d, J=2.1Hz, 1H), 7.66–7.72(m, 2H) IR(KBr)1510, 1477, 1376, 1358, 1349, 1294, 1237, 1196, 1173, 1145, 1077, 1004, 958, 861, 801cm⁻¹ I-1102 mp 168–169° C. ¹H NMR(CDCl₃) δ 1.76(d, J=0.3Hz, 3H), 1.80(d, J=0.9Hz, 3H), 3.44(s, 3H), 3.75(s, 3H), 4.64(d, J=6.6Hz, 2H), 4.97 (s, 1H), 5.55(m, 1H), 6.00(s, 1H), 6.45(s, 1H), 6.89–6.95(m, 2H), 7.01(d, J=8.4Hz, 1H), 7.33(dd, J=2.1, 8.4Hz, 1H), 7.51 (d, J=2.1Hz, 1H), 7.51–7.56(m, 2H) IR(KBr)3396, 1613, 1521, 1485, 1467, 1440, 1408, 1384, 1357, 1286, 1264, 1229, 1116, 1076, 1056, 993, 834cm⁻¹ I-1103 mp 176–177° C. ¹H NMR(CDCl₃) δ 1.77(s, 3H), 1.80(s, 3H), 2.09(s, 3H), 2.16(s, 3H), 3.87(s, 3H), 4.65(d, J=7.2Hz, 2H), 4.78(br s, 1H), 5.06(s, 1H), 5.40–5.60(m, 1H), 6.76(s, 1H), 6.82–6.91(m, 4H), 7.02(d, J=7.8Hz, 1H), 7.22–7.27(m, 2H) IR(CHCl₃)3597, 3533, 3026, 3010, 2921, 1731, 1612, 1520, 1488, 1240, 1172cm⁻¹ I-1104 mp 185–186° C. ¹H NMR(CDCl₃) δ 1.78(s, 3H), 1.82(s, 3H), 2.06(s, 3H), 2.15(s, 3H), 4.66(d, J=6.9Hz, 2H), 4.71(s, 1H), 4.89(s, 1H), 5.53–5.58(m, 1H), 6.75(s, 1H), 6.86–6.91(m, 2H), 6.90–7.00(m, 3H), 7.21–7.26(m, 2H) IR(CHCl₃)3691, 3598, 3546, 3068, 2922, 1674, 1613, 1520, 1488, 1298, 1262, 1165cm⁻¹ I-1105 mp 143–144° C. ¹H NMR(CDCl₃) δ 2.48(s, 3H), 3.21(s, 3H), 3.52(s, 3H), 3.67(d, J=1.2Hz, 3H), 3.92(s, 3H), 5.23(s, 2H), 6.92–7.02(m, 3H), 7.31–7.48(m, 7H), 7.60(dd, J=8.7, 1.5Hz, 2H) IR(KBr)1519, 1470, 1370, 1256, 1173, 1152, 1029, 872cm⁻¹

TABLE 218 I-1106 mp 128–130° C. ¹H NMR(CDCl₃) δ 1.76(s, 3H), 1.80(s, 3H), 2.59(s, 3H), 3.21(s, 3H), 3.53(s, 3H), 3.67(d, J=0.9Hz, 3H), 3.90(s, 3H), 4.64(d, J=6.9Hz, 2H), 5.55(t, J=6.9Hz, 1H), 6.97–7.00(m, 3H), 7.41(d, J=8.8Hz, 2H), 7.60(dd, J=8.8, 1.1Hz, 2H) IR(KBr)1519, 1361, 1258, 1175, 1148, 1041, 978, 874cm⁻¹ I-117 mp 168–170° C. ¹H NMR(CDCl₃) δ 1.76(s, 3H), 1.79(s, 3H), 3.43(s, 3H), 3.63(d, J=0.9Hz, 3H), 3.89(s, 3H), 4.65(d, J=6.8Hz, 2H), 5.01(s, 1H), 5.57(t, J=6.8Hz, 1H), 5.65(s, 1H), 6.90–7.06(m, 5H), 7.43(dd, J=8.7, 1.5Hz, 2H) IR(KBr)3433, 1523, 1464, 1397, 1253, 1216, 1038, 977, 838, 814cm⁻¹ I-1108 mp 127–128° C. ¹H NMR(CDCl₃) δ 2.25(s, 3H), 2.27(s, 3H), 3.20(s, 3H), 5.22(s, 2H), 7.02(d, J=8.4Hz, 1H), 7.10(s, 1H), 7.11(s, 1H), 7.18(dd, J=2.1, 8.4Hz, 1H), 7.31–7.54(m, 10H) IR(KBr)1513, 1484, 1369, 1284, 1243, 1175, 1150, 1061, 984, 968, 868, 847, 791, 718cm⁻¹ I-1109 mp 161–162° C. ¹H NMR(CDCl₃) δ 2.26(s, 3H), 2.28(s, 3H), 5.16(s, 2H), 5.19(s, 2H), 5.70(br s, 1H), 6.82(dd, J=2.1, 8.4Hz, 1H), 6.96–7.16 (m, 7H), 7.31–7.51(m, 10H) IR(KBr)3449, 1521, 1492, 1470, 1455, 1394, 1294, 1279, 1247, 1232, 1199, 1185, 1129, 1013, 740, 695cm⁻¹ I-110 mp 133–134° C. ¹H NMR(CDCl₃) δ 2.26(s, 6H), 4.80(br s, 1H), 5.21(s, 2H), 6.85–6.93(m, 2H), 7.02(d, J=8.4Hz, 1H), 7.09(s, 1H), 7.17 (s, 1H), 7.15–7.52(m, 9H) IR(KBr)3350, 1601, 1519, 1485, 1453, 1387, 1289, 1255, 1169, 1060, 839, 813, 731cm⁻¹

TABLE 219 I-1111 mp 83–84° C. ¹H NMR(CDCl₃) δ 1.78(d, J=0.3Hz, 3H), 1.82(d, J=0.9Hz, 3H), 2.26(s, 3H), 2.27(s, 3H), 3.20(s, 3H), 4.65(d, J=6.6Hz, 2H), 5.55(m, 1H), 6.99(d, J=8.4Hz, 1H), 7.11(s, 1H), 7.12(s, 1H), 7.19(dd, J=2.1, 8.4Hz, 1H), 7.38(d, J=2.1Hz, 1H), 7.32–7.43(m, 4H) IR(KBr)1514, 1485, 1364, 1286, 1253, 1197, 1178, 1156, 1057, 976, 882, 851cm⁻¹ I-1112 mp 86–87° C. ¹H NMR(CDCl₃) δ 1.77(d, J=0.6Hz, 3H), 1.82(d, J=0.9Hz, 3H), 2.27(s, 6H), 4.65(d, J=6.6Hz, 2H), 5.00(s, 1H), 5.55 (m, 1H), 6.86–6.92(m, 2H), 6.98(d, J=8.4Hz, 1H), 7.10(s, 1H), 7.11(s, 1H), 7.20(dd, J=2.1, 8.4Hz, 1H), 7.22–7.26(m, 2H), 7.38(d, J=2.1Hz, 1H) IR(KBr)3339, 1608, 1530, 1492, 1429, 1362, 1288, 1258, 1232, 1213, 1189, 1112, 889, 783cm⁻¹ I-1113 amorphous ¹H NMR(CDCl₃) δ 1.76(s, 3H), 3.32(s, 6H), 3.44(s, 3H), 3.74(s, 3H), 5.23(s, 2H), 7.02(s, 1H), 7.14–7.20(m, 2H), 7.28(d, J=8.7Hz, 1H), 7.32–7.55(m, 7H), 7.72(d, J=8.4Hz, 2H), 9.22(s, 1H), IR(KBr)3382, 1684, 1518, 1469, 1365, 1237, 1150, 1017, 972, 872, 815cm⁻¹ I-1114 mp 173–175° C. ¹H NMR(CDCl₃) δ 1.76(s, 3H), 1.81(s, 3H), 1.97(s, 3H), 3.19(s, 6H), 3.21(s, 3H), 3.37(s, 3H), 3.75(s, 3H), 4.62(d, J=6.9Hz, 2H), 5.50(t, J=6.9Hz, 1H), 6.85(m, 2H), 7.06(d, J=8.4Hz, 1H), 7.25(m, 1H), 7.37(br s, 1H), 7.66(d, J=8.7Hz, 2H) IR(KBr)3421, 1518, 1470, 1366, 115, 1107, 970, 814cm⁻¹

TABLE 220 I-1115 mp 96–98° C. ¹H NMR(DMSO-d₆) δ 1.72(s, 3H), 1.77(s, 3H), 3.27(s, 3H), 3.59(s, 3H), 4.21(s, 2H), 4.55(d, J=6.3Hz, 2H), 5.50(t, J=6.3Hz, 1H), 6.17(s, 1H), 6.59(dd, J=8.1, 1.8Hz, 1H), 6.66(d, J=1.8Hz, 1H), 6.82(d, J=8.7Hz, 2H), 6.97(d, J=8.1Hz, 1H), 7.42(d, J=8.7Hz, 2H), 8.89(br s, 1H), 9.45(br s, 1H) IR(KBr) 3431, 3396, 3319, 1611, 1521, 1486, 1264, 1172, 1111, 987, 826cm⁻¹ I-1116 mp 186–188° C. ¹H NMR(DMSO-d₆) δ 1.72(s, 3H), 1.76(s, 6H), 3.28(s, 3H), 3.68(s, 3H), 4.54(d, J=6.6Hz, 2H), 5.48(t, J=6.6Hz, 1H), 6.53–6.58(m, 1H), 6.65(d, J=1.8Hz, 1H), 6.83–6.89(m, 4H), 7.43(d, J=8.4Hz, 2H), 8.73(br s, 1H), 8.96(br s, 1H), 9.53 (br s, 1H) IR(KBr) 3429, 1652, 1611, 1519, 1474, 1250, 1080, 1018, 981, 836cm⁻¹ I-1117 mp 210–213° C. ¹H NMR(CDCl₃) δ 3.48(s, 3H), 3.77(s, 3H), 5.16(s, 2H), 5.71(s, 1H), 5.85(s, 1H), 6.48(s, 1H), 6.95(dd, J=8.4, 2.1Hz, 1H), 7.04(d, J=8.4Hz, 1H), 7.07(d, J=2.1Hz, 1H), 7.40–7.48(m, 5H), 7.83(d, J=9.0Hz, 2H), 8.32(d, J=9.0Hz, 2H) IR(KBr) 3499, 1511, 1343, 1284, 1247, 1195, 1109, 1070, 1013cm⁻¹ I-1118 mp 156–158° C. ¹H NMR(CDCl₃) δ 2.67(s, 3H), 3.14(s, 3H), 3.56(s, 3H), 3.80(s, 3H), 5.20(s, 2H), 6.87(s, 1H), 7.16(d, J=8.7Hz, 1H), 7.32–7.48(m, 7H), 7.82(d, J=9.2Hz, 2H), 8.32(d, J=9.2Hz, 2H) IR(KBr) 1518, 1479, 1350, 1177, 1119, 1079, 947, 816cm⁻¹ I-1119 mp 173–175° C. ¹H NMR(CDCl₃) δ 1.77(s, 3H), 1.81(s, 3H), 2.71(s, 3H), 3.24(s, 3H), 3.57(s, 3H), 3.80(s, 3H), 4.64(d, J=6.7Hz, 2H), 5.50(t, J=6.7Hz, 1H), 6.87(s, 1H), 7.10(d, J=8.4Hz, 1H), 7.35(d, J=8.4, 2.1Hz, 1H), 7.39(d, J=2.0Hz, 1H), 7.82(d, J=9.0Hz, 2H), 8.32(d, J=9.0Hz, 2H) IR(KBr) 1519, 1479, 1360, 1178, 1075, 946, 850, 799cm⁻¹

TABLE 221 I-1120 mp 191–193° C. ¹H NMR(CDCl₃) δ 1.77(s, 3H), 1.82(s, 3H), 3.48(s, 3H), 3.77(s, 3H), 4.63(d, J=6.6Hz, 2H), 5.53(t, J=6.6Hz, 1H), 5.72(s, 1H), 5.83(s, 1H), 6.48(s, 1H), 6.93(dd, J=8.1, 1.8Hz, 1H), 6.98(d, J=8.1Hz, 1H), 7.04(d, J=1.8Hz, 1H), 7.83(d, J=9.0Hz, 2H), 8.32(d, J=9.0Hz, 2H) IR(KBr) 3492, 1588, 1511, 1482, 1345, 1283, 1244, 1116, 1069, 1010cm⁻¹ I-1121 mp 135–138° C. ¹H NMR(CDCl₃) δ 1.76(s, 3H), 1.82(s, 3H), 3.61(s, 3H), 3.67(s, 3H), 3.73(s, 3H), 4.62(d, J=6.9Hz, 2H), 5.00(br. s, 1H), 5.50–5.57(m, 1H), 5.69(br. s, 1H), 6.65(s, 1H), 6.86–6.96(m, 4H), 7.00(d, J=1.8Hz, 1H), 7.48(d, J=8.4Hz, 2H) IR(KBr) 3428, 2938, 1680, 1613, 1594, 1520, 1479, 1460, 1393, 1260, 1226, 1104, 1081, 993, 834cm⁻¹ I-1122 mp 140–142° C. ¹H NMR(CDCl₃) δ 1.78(s, 3H), 1.82(s, 3H), 2.34(s, 3H), 4.65–4.67(d, J=6.9Hz, 2H), 5.55(m, 1H), 6.41–6.78(dt, J F-H=54.6, 3.3Hz, 2H), 7.05–7.25(m, 5H), 7.26–7.45(m, 2H), 7.75(m, 2H) IR(CHCl₃) 1752, 1523, 1493, 1435, 1385, 1301, 1272, 1169, 1132, 1070, 1037, 916, 889cm⁻¹ I-1123 mp 178–180° C. ¹H NMR(CDCl₃) δ 1.75(s, 3H), 1.78–1.79(d, J=0.6Hz, 3H), 2.13(s, 3H), 3.50(s, 3H), 3.87(s, 3H), 4.63–4.65(d, J=6.6Hz, 2H), 5.00(br, 1H), 5.57(m, 1H), 5.75(s, 1H), 6.79(s, 1H), 6.84–7.00(m, 5H), 7.50–7.53(m, 2H) IR(CHCl₃) 3596, 3528, 2937, 1612, 1584, 1522, 1489, 1454, 1400, 1259, 1173, 1139, 1102, 1009, 930, 865, 835cm⁻¹ I-1124 mp 173–174° C. ¹H NMR(CDCl₃) δ 3.03(s, 6H), 3.54(s, 3H), 3.76(s, 3H), 3.91(s, 3H), 5.22(s, 2H), 6.80–6.99(m, 6H), 7.28–7.58(m, 7H) IR(CHCl₃) 2938, 1731, 1609, 1527, 1485, 1442, 1394, 1365, 1174, 1141, 1082, 1037, 1013, 961, 936, 863cm⁻¹

TABLE 222 I-1125 mp 103–106° C. ¹H NMR(CDCl₃) δ 1.78(s, 3H), 1.82–1.83(d, J=0.9Hz, 3H), 4.65–4.67(d, J=6.9Hz, 2H), 5.55(m, 1H), 6.41–6.78(td, J F-H=54.9, 2.7Hz, 2H), 6.94–7.31(m, 7H), 7.73(m, 2H) IR(CHCl₃) 3592, 1612, 1525, 1495, 1385, 1301, 1263, 1187, 1173, 1132, 1069, 1036, 917, 889, 838cm⁻¹ I-1126 mp 153–155° C. ¹H NMR(CDCl₃) δ 1.75(s, 3H), 1.78–1.79(d, J=0.9Hz, 3H), 2.58(s, 3H), 3.03(s, 6H), 3.55(s, 3H), 3.77(s, 3H), 3.88(s, 3H), 4.61–4.64(d, J=6.9Hz, 2H), 5.54(m, 1H), 6.80–6.97(m, 6H), 7.54–7.57(d, J=8.7Hz, 2H) IR(CHCl₃) 2938, 1609, 1527, 1485, 1464, 1442, 1392, 1365, 1174, 1140, 1082, 1038, 1012, 961, 935cm⁻¹ I-1127 mp 160–161° C. ¹H NMR(CDCl₃) δ 2.12(s, 3H), 3.49(s, 3H), 3.89(s, 3H), 4.89(br, 1H), 5.21(s, 2H), 5.76(s, 1H), 6.79–6.92(m, 5H), 7.00 (d, J=8.4Hz, 1H), 7.31–7.53(m, 7H) IR(CHCl₃) 3594, 3517, 2937, 1731, 1612, 1589, 1522, 1489, 1455, 1400, 1327, 1259, 1240, 1173, 1139, 1102, 1011, 930, 865, 835cm⁻¹ I-1128 mp 149–150° C. ¹H NMR(CDCl₃) δ 1.74–1.75(d, J=0.9Hz, 3H), 1.78–1.79(d, J=0.9Hz, 3H), 3.03(s, 1H), 3.49(s, 6H), 3.75(s, 3H), 3.88 s, 3H), 4.62–4.64(d, J=6.6Hz, 2H), 5.57(m, 1H), 5.95(s, 1H), 6.49(s, 1H), 6.81–6.84(m, 2H), 6.95–7.03(m, 3H), 7.55–7.58 (m, 2H) IR(CHCl₃) 3509, 2937, 1675, 1610, 1584, 1528, 1492, 1464, 1397, 1362, 1323, 1197, 1175, 1140, 1117, 1078, 1038, 1011, 929, 835cm⁻¹ I-1129 mp 163–165° C. ¹H NMR(CDCl₃) δ 2.15(s, 3H), 2.47(s, 3H), 3.20(s, 3H), 3.55(s, 3H), 3.90(s, 3H), 5.22(s, 2H), 6.80(dd, J=8.4, 2.1Hz, 1H), 6.88(d, J=2.1Hz, 1H), 7.00(d, J=8.4Hz, 1H), 7.17(s, 1H), 7.35–7.47(m, 7H), 7.66–7.69(m, 2H) IR(CHCl₃) 2938, 1604, 1584, 1518, 1478, 1370, 1331, 1241, 1176, 1150, 1010, 987, 937, 872, 846cm⁻¹

TABLE 223 I-1130 mp 142–144° C. ¹H NMR(CDCl₃) δ 1.76–1.77(d, J=0.9Hz, 3H), 1.79–1.80(d, J=0.9Hz, 3H), 2.16(s, 3H), 2.60(s, 3H), 3.20(s, 3H), 3.57 (s, 3H), 3.88(s, 3H), 4.62–4.65(d, J=6.6Hz, 2H), 5.55(m, 1H), 6.83–6.87(m, 2H), 7.00(d, J=8.4Hz, 1H), 7.18(s, 1H), 7.35–7.38(m, 2H), 7.67–7.70(m, 2H) IR(CHCl₃) 1604, 1582, 1517, 1478, 1416, 1370, 1332, 1240, 1176, 1150, 1093, 1008, 987, 936, 872cm⁻¹ I-1131 mp 121–123° C. ¹H NMR(DMSO-d₆) δ 1.70(s, 3H), 1.71(s, 3H), 3.71–3.75(m, 4H), 3.75(s, 6H), 5.21–5.27(m, 2H), 5.54–5.59(m, 2H), 6.65–6.71(m, 2H), 6.95(s, 2H), 7.19–7.29(m, 4H) IR(KBr) 3600–2800(br), 1627, 1536, 1497, 1470, 1454, 1375, 1341, 1257, 1208, 1125, 1053, 1035cm⁻¹ I-1132 mp 169–170° C. ¹H NMR(CDCl₃) δ 1.77(d, J=0.6Hz, 3H), 1.81(d, J=0.9Hz, 3H), 2.26(s, 6H), 4.63(d, J=6.6Hz, 2H), 5.31(s, 1H), 5.34 (s, 1H), 5.55(m, 1H), 6.80(dd, J=2.1, 8.1Hz, 1H), 6.89(d, J=2.1Hz, 1H), 6.92(d, J=8.1Hz, 1H), 6.98–7.13(m, 5H) IR(KBr) 3338, 1619, 1595, 1523, 1492, 1475, 1451, 1427, 1385, 1357, 1309, 1298, 1270, 1223, 1193, 1172, 1122, 1113, 999, 983, 871, 819, 785cm⁻¹ I-1133 mp 135–136° C. ¹H NMR(CDCl₃) δ 1.14(t, J=6.9Hz, 3H), 2.42(s, 3H), 3.20(s, 3H), 3.73(q, J=6.9Hz, 2H), 3.77(s, 3H), 3.91(s, 3H), 5.22(s, 2H), 6.84(s, 1H), 6.91(dd, J=1.8, 8.4Hz, 1H), 6.98(d, J=8.4Hz, 1H), 6.98(d, J=1.8Hz, 1H), 7.28–7.47(m, 7H), 7.68–7.73(m, 2H) IR(KBr) 1516, 1481, 1381, 1363, 1332, 1238, 1228, 1175, 1147, 1080, 1036, 865, 843, 800cm⁻¹

TABLE 224 I-1134 mp 154–155° C. ¹H NMR(CDCl₃) δ 1.15(t, J=7.2Hz, 3H), 1.75(d, J=0.9Hz, 3H), 1.79(d, J=0.9Hz, 3H), 2.54(s, 3H), 3.21(s, 3H), 3.72 (q, J=7.2Hz, 2H), 3.78(s, 3H), 3.88(s, 3H), 4.63(d, J=6.9Hz, 2H), 5.54(m, 1H), 6.85(s, 1H), 6.95–6.98(m, 3H), 7.34–7.40 (m, 2H), 7.68–7.74(m, 2H) IR(KBr) 1519, 1481, 1467, 1365, 1335, 1245, 1231, 1184, 1157, 1081, 1038, 972, 889, 872, 840, 800cm⁻¹ I-1135 mp 136–137° C. ¹H NMR(CDCl₃) δ 1.16(t, J=6.9Hz, 3H), 1.74(s, 3H), 1.78(s, 3H), 3.61(q, J=6.9Hz, 2H), 3.75(s, 3H), 3.88(s, 3H), 4.63(d, J=6.9Hz, 2H), 5.03(s, 1H), 5.57(m, 1H), 5.99(s, 1H), 6.46(s, 1H), 6.89–6.94(m, 2H), 6.97(d, J=8.7Hz, 1H), 7.01 (d, J=1.8Hz, 1H), 7.02(dd, J=1.8, 8.7Hz, 1H), 7.51–7.57(m, 2H) IR(KBr) 3433, 1613, 1522, 1489, 1464, 1443, 1402, 1383, 1364, 1270, 1235, 1214, 1174, 1140, 1113, 1072, 1036, 983, 825cm⁻¹ I-1136 mp 155–157° C. ¹H NMR(CDCl₃) δ 2.05(t, J=2.7Hz, 1H), 2.76(dt, J=6.3, 2.7Hz, 2H), 2.77(s, 3H), 3.21(s, 3H), 3.28(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 4.23(t, J=6.3Hz, 2H), 6.84(s, 1H), 7.09(d, J=8.4Hz, 1H), 7.36(dd, J=8.4, 2.1Hz, 1H), 7.38(d, J=8.7Hz, 2H), 7.41(d, J=2.1Hz, 1H), 7.68(d, J=8.7Hz, 2H) IR(Nujol) 3285, 1608, 1519, 1176, 1151, 1119, 1079, 970, 870, 815, 797cm⁻¹ I-1137 foam ¹H NMR(CDCl₃) δ 1.83(s, 3H), 2.58(t, J=6.6Hz, 2H), 2.74(s, 3H), 3.21(s, 3H), 3.22(s, 3H), 3.56(s, 3H), 3.78(s, 3H), 4.22(t, J=6.6Hz, 2H), 4.84(brs, 1H), 4.89(brs, 1H), 6.84(s, 1H), 7.10(d, J=8.4Hz, 1H), 7.32–7.43(m, 4H), 7.68(d, J=8.7Hz, 2H), IR(Nujol) 1608, 1519, 1176, 1150, 1119, 1078, 968, 869, 816cm⁻¹

TABLE 225 I-1138 foam ¹H NMR(CDCl₃) δ 1.81(s, 3H), 2.55(t, J=6.6Hz, 2H), 3.45(s, 3H), 3.74(s, 3H), 4.20(t, J=6.6Hz, 2H), 4.85(brs, 1H), 4.89(brs, 1H), 6.45(s, 1H), 6.86–7.07(m, 5H), 7.53(d, J=8.7Hz, 2H), IR(Nujol) 3531, 3328, 1612, 1587, 1523, 1489, 1287, 1226, 1115, 1072, 1011cm⁻¹ I-1139 foam ¹H NMR(CDCl₃) δ 2.07(t, J=2.7Hz, 1H), 2.72(dt, J=6.6, 2.7Hz, 2H), 3.45(s, 3H), 3.75(s, 3H), 4.21(t, J=6.6Hz, 2H), 6.45(s, 1H), 6.87–7.10(m, 5H), 7.53(d, J=8.7Hz, 2H) IR(Nujol) 3482, 3305, 1609, 1597, 1527, 1494, 1253, 1240, 1227, 1127, 1118, 1079, 1010cm⁻¹ I-1140 m.p 194–197° C. ¹H NMR(DMSO) δ 3.29(s, 3H), 3.64(s, 3H), 5.42(s, 2H), 6.38(s, 1H), 6.61(dd, J=2.0, 8.2Hz, 1H), 6.74(d, J=2.0Hz, 1H), 6.84(d, J=8.6Hz, 2H), 6.96(d, J=8.2Hz, 1H), 7.19(d, J=7.8Hz, 1H), 7.41(d, J=7.8Hz, 1H), 7.43(d, J=8.4Hz, 2H) IR(KBr) 3432, 1611, 1566, 1523, 1488, 1430, 1400, 1380, 1241, 1113, 1071, 814cm⁻¹ I-1141 foam ¹H NMR(CDCl₃) δ 3.45(s, 3H), d 3.75(s, 3H), 3.92(s, 3H), 5.53(s, 2H), 6.45(s, 1H), 6.92(d, J=8.7Hz, 2H), 6.94(dd, J=2.1, 8.7Hz, 1H), 7.01(d, J=8.7Hz, 1H), 7.10(d, J=2.1Hz, 1H), 7.28(d, J=4.8Hz, 1H), 7.52(d, J=4.8Hz, 1H), 7.53(d, J=8.4Hz, 2H) IR(KBr) 3423, 1702, 1684, 1611, 1523, 1489, 1439, 1402, 1282, 1112, 1073, 1010, 814cm⁻¹ I-1142 foam ¹H NMR(CDCl₃) δ 2.74(s, 3H), 3.21(s, 3H), 3.22(s, 3H), 3.55(s, 3H), d 3.78(s, 3H), 3.91(s, 3H), 5.19(s, 2H), 6.60(d, J=3.6Hz, 1H), 6.84(s, 1H), 7.15(d, J=8.4Hz, 1H), 7.17(d, J=3.6Hz, 1H), 7.36(dd, J=2.1, 8.4Hz, 1H), 7.38(d, J=8.7Hz, 2H), 7.41(d, J=2.1Hz, 1H), 7.67(d, J=8.7Hz, 2H) IR(KBr) 1728, 1519, 1481, 1365, 1177, 1150, 1079, 969, 876, 797cm⁻¹

TABLE 226 I-1143 foam ¹H NMR(CDCl₃) δ 2.77(s, 3H), 3.21(s, 3H), 3.23(s, 3H), 3.56(s, 3H), d 3.78(s, 3H), 4.18(m, 2H), 4.78(m, 2H), 5.94(m, 2H), 6.84(s, 1H), 7.11(d, J=8.4Hz, 1H), 7.36(dd, J=2.1, 8.4Hz, 1H), 7.38(d, J=8.7Hz, 2H), 7.40(d, J=2.1Hz, 1H), 7.67(d, J=8.7Hz, 2H) IR(KBr) 1609, 1519, 1481, 1367, 1177, 1150, 1079, 970, 876, 797cm⁻¹ I-1144 foam ¹H NMR(CDCl₃) δ 2.75(s, 3H), 3.21(s, 3H), 3.24(s, 3H), 3.55(s, 3H), d 3.78(s, 3H), 4.11(m, 2H), 4.64(m, 2H), 6.05(t, J=4.5Hz, 1H), 6.06(t, J=5.1Hz, 1H), 6.84(s, 1H), 7.07(d, J=8.7Hz, 1H), 7.35(dd, J=2.1, 8.7Hz, 1H), 7.38(d, J=8.7Hz, 2H), 7.40(d, J=2.1Hz, 1H), 7.67(d, J=8.7Hz, 2H) IR(KBr) 1609, 1519, 1481, 1364, 1177, 1151, 1079, 969, 874, 797cm⁻¹ I-1145 m.p 203–205° C. ¹H NMR(CDCl₃) δ 2.83(s, 3H), 3.22(s, 3H), 3.25(s, 3H), 3.55(s, 3H), d 3.79(s, 3H), 4.30(t, J=1.8Hz, 2H), 4.88(t, J=1.8Hz, 2H), 6.84(s, 1H), 7.20(d, J=8.7Hz, 1H), 7.37(dd, J=2.1, 8.7Hz, 1H), 7.39(d, J=8.7Hz, 2H), 7.42(d, J=2.1Hz, 1H), 7.67(d, J=8.7Hz, 2H) IR(KBr) 3443, 1606, 1519, 1481, 1360, 1179, 1150, 1079, 877, 798cm⁻¹ I-1146 m.p 173–174° C. ¹H NMR(CD3OD) δ 3.38(s, 3H), 3.68(s, 3H), 4.23(t, J=1.8Hz, 2H), 4.83(t, J=1.8Hz, 2H), 6.43(s, 1H), 6.79(dd, J=2.1, 8.1Hz, 1H), 6.85(d, J=8.7Hz, 2H), 6.86(d, J=2.1Hz, 1H), 7.04(d, J=8.1Hz, 1H), 7.45(d, J=8.7Hz, 2H) IR(KBr) 3399, 1612, 1586, 1523, 1487, 1401, 1217, 1114, 1067, 1013, 996, 828cm⁻¹

TABLE 227 I-1147 foam ¹H NMR(CDCl₃) δ 3.39(s, 3H), 3.45(s, 3H), 3.74(s, 3H), 4.17(t, J=1.8Hz, 2H), 4.83(t, J=1.8Hz, 2H), 6.45(s, 1H), 6.91(d, J=8.7Hz, 2H), 6.97(dd, J=2.1, 8.1Hz, 1H), 7.05(d, J=8.1Hz, 1H), 7.08(d, J=2.1Hz, 1H), 7.52(d, J=8.7Hz, 2H) IR(KBr) 3411, 1612, 1589, 1523, 1489, 1404, 1224, 1114, 1071, 1010, 939, 816cm⁻¹ I-1148 foam ¹H NMR(CDCl₃) δ 1.14(t, J=7.5Hz, 3H), 2.23(q, J=7.5Hz, 2H), 2.71(s, 3H), 3.21(s, 3H), 3.27(s, 3H), 3.60(s, 3H), 3.78(s, 3H), 4.80(s, 2H), 6.84(s, 1H), 7.20(d, J=9.0Hz, 1H), 7.37(dd, J=2.1, 9.0Hz, 1H), 7.38(d, J=8.7Hz, 2H), 7.42(d, J=2.1Hz, 1H), 7.68(d, J=8.7Hz, 2H) IR(KBr) 2232, 1609, 1519, 1481, 1365, 1177, 1151, 1079, 970, 876, 797cm⁻¹ I-1149 mp > 280° C.(decomp.) ¹H NMR(DMSO-d₆) δ 3.30(s, 3H), 3.64(s, 3H), 4.85(s, 2H), 6.39(s, 1H), 6.69(dd, J=8.4, 2.1Hz, 1H), 6.79(d, J=2.1Hz, 1H), 6.84(d, J=8.7Hz, 2H), 6.94(d, J=8.4Hz, 1H), 7.44(d, J=8.7Hz, 2H), 8.54(s, 1H) IR(Nujol) 3166, 1707, 1671, 1611, 1586, 1523, 1489, 1288, 1259, 1211, 1115, 1075, 1012, 814cm⁻¹ I-1150 foam ¹H NMR(CDCl₃) δ 1.91(s, 3H), 3.45(s, 3H), 3.75(s, 3H), 4.89(s, 2H), 5.29(brs, 1H), 5.36(brs, 1H), 6.45(s, 1H), 6.92(d, J=8.7Hz, 2H), 6.97(dd, J=8.4, 2.1Hz, 1H), 7.07(d, J=8.4Hz, 1H), 7.08(d, J=2.1Hz, 1H), 7.54(d, J=8.7Hz, 2H) IR(KBr) 3432, 1612, 1588, 1523, 1489, 1288, 1224, 1192, 1113, 1070, 1010, 938, 825, 813cm⁻¹ I-1151 foam ¹H NMR(CDCl₃) δ 3.45(s, 3H), 3.75(s, 3H), 4.98(d, J=1.8Hz, 2H), 5.92(dt, J=7.5, 1.8Hz, 1H), 6.45(s, 1H), 6.46(d, J=7.5Hz, 1H), 6.92(d, J=8.7Hz, 2H), 6.98(dd, J=8.4, 2.1Hz, 1H), 7.09(d, J=2.1Hz, 1H), 7.11(d, J=8.4Hz, 1H), 7.53 (d, J=8.7Hz, 2H) IR(KBr) 3410, 1612, 1589, 1523, 1489, 1403, 1224, 1112, 1070, 1011, 938, 826cm⁻¹

TABLE 228 I-1152 foam ¹H NMR(CDCl₃) δ 3.45(s, 3H), 3.75(s, 3H), 4.89(d, J=2.1Hz, 2H), 5.97(dt, J=13.8, 2.1Hz, 1H), 6.45(s, 1H), 6.61(d, J=13.8Hz, 1H), 6.92(d, J=8.7Hz, 2H), 6.97(dd, J=8.4, 2.1Hz, 1H), 7.04(d, J=8.4Hz, 1H), 7.09(d, J=2.1Hz, 1H), 7.54 (d, J=8.7Hz, 2H) IR(KBr) 3427, 1612, 1588, 1523, 1489, 1403, 1226, 1192, 1175, 1113, 1070, 1011, 938, 918, 826cm⁻¹ I-1153 mp 188–189° C. ¹H NMR(CDCl₃) δ 2.84(s, 3H), 3.33(s, 3H), 3.74(s, 3H), 3.98(s, 3H), 4.18(s, 3H), 5.38(s, 2H), 7.05(s, 1H), 7.36–7.64(m, 10H), 8.61(d, J=8.7Hz, 1H), 8.82(brs, 1H) IR(KBr) 3381, 2942, 1724, 1538, 1481, 1369, 1296, 1177, 1163, 1082, 963, 821cm⁻¹ I-1154 mp 78–80° C. ¹H NMR(CDCl₃) δ 2.17(s, 3H), 2.67(s, 3H), 3.13(s, 3H), 3.57(s, 3H), 3.79(s, 3H), 5.19(s, 2H), 6.83(s, 1H), 7.15(d, J=8.6Hz, 1H), 7.31–7.45(m, 7H), 7.62(d, J=8.2Hz, 1H), 7.79(s, 1H), 8.44(d, J=8.6Hz, 1H), 8.51(brs, 1H) IR(KBr) 3398, 2939, 1739, 1529, 1477, 1368, 1287, 1240, 1177, 1119, 1078, 957, 815, 796, 522cm⁻¹ I-1155 mp 74–75° C. ¹H NMR(CDCl₃) δ 1.68(s, 3H), 1.76(s, 6H), 1.81(s, 3H), 2.69(s, 3H), 3.24(s, 3H), 3.52(s, 3H), 3.80(s, 3H), 3.88(s, 3H), 3.88–4.02(m, 2H), 4.64(d, J=7.2Hz, 2H), 5.25(t, J=7.8Hz, 1H), 5.50(t, J=5.7Hz, 1H), 6.88(s, 1H), 7.08–7.38(m, 6H) IR(KBr) 3412, 2939, 1697, 1519, 1483, 1366, 1268, 1207, 1178, 1080, 964, 808, 523cm⁻¹ I-1156 mp 72–74° C. ¹H NMR(CDCl₃) δ 1.95(s, 3H), 1.99(s, 3H), 2.87(s, 3H), 3.42(s, 3H), 3.74(s, 3H), 3.97(s, 3H), 4.16(s, 3H), 4.82(d, J=6.6Hz, 2H), 5.68(t, J=5.7Hz, 1H), 7.04(s, 1H), 7.27(d, J=8.1Hz, 1H), 7.39–7.56(m, 4H), 8.60(d, J=8.4Hz, 1H), 8.81 (brs, 1H) IR(KBr) 3407, 2940, 1731, 1601, 1538, 1481, 1366, 1294, 1178, 1165, 1079, 805, 562cm⁻¹

TABLE 229 I-1157 mp 68–69° C. ¹H NMR(CDCl₃) δ 1.70(s, 3H), 1.77(s, 3H), 1.81(s, 3H), 2.70(s, 3H), 3.25(s, 3H), 3.55(s, 3H), 3.81(s, 3H), 4.64(d, J=6.6Hz, 2H), 5.27(t, J=7.5Hz, 1H), 5.50(t, J=6.9Hz, 1H), 6.86(s, 1H), 7.10(d, J=8.4Hz, 1H), 7.25–7.40(m, 3H), 7.57(d, J=8.1Hz, 1H), 7.76(s, 1H) IR(KBr) 3422, 2939, 1701, 1519, 1480, 1368, 1203, 1177, 1078, 957, 801, 522cm⁻¹ I-1158 mp 64–66° C. ¹H NMR(CDCl₃) δ 3.47(s, 3H), 3.74(s, 3H), 5.19(s, 2H), 5.86(brs, 1H), 6.44(s, 1H), 7.08–7.69(m, 11H), 8.06(brs, 1H) IR(KBr) 3399, 2938, 1726, 1624, 1604, 15263, 1487, 1403, 1302, 1208, 1178, 1068, 695, 520cm⁻¹ I-119 mp 68–70° C. ¹H NMR(CDCl₃) δ 2.57(s, 3H), 3.57(s, 3H), 3.76(s, 3H), 5.21(s, 2H), 6.84(s, 1H), 7.11–7.73(m, 11H), 8.29(brs, 1H) IR(KBr) 3422, 2939, 1728, 1605, 1523, 1482, 1397, 1367, 1233, 1209, 1178, 1078, 795, 725, 542cm⁻¹ I-1160 mp 72–73° C. ¹H NMR(CDCl₃) δ 1.75(s, 6H), 1.78(s, 3H), 1.82(s, 3H), 3.48(s, 3H), 3.75(s, 3H), 3.76(d, J=7.2Hz, 2H), 3.89(s, 3H), 4.38(brs, 1H), 4.61(d, J=6.9Hz, 2H), 5.41(t, J=6.3Hz, 1H), 5.53(t, J=6.9Hz, 1H), 5.68(brs, 1H), 5.94(brs, 1H), 6.49(s, 3H), 6.69(d, J=8.4Hz, 1H), 6.95(s, 1H), 7.06(s, 1H), 7.13–7.15(m, 2H), 7.26(s, 1H) IR(KBr) 3423, 2932, 1608, 1528, 1490, 1459, 1250, 1113, 1071, 805, 757cm⁻¹ I-1161 mp 68–69° C. ¹H NMR(CDCl₃) δ 1.76(s, 3H), 1.81(s, 3H), 3.48(s, 3H), 3.75(s, 3H), 3.91(s, 3H), 4.61(d, J=7.2Hz, 2H), 5.53(t, J=6.0Hz, 1H), 5.91(brs, 2H), 6.47(s, 1H), 6.83(d, J=8.1Hz, 2H), 6.95(s, 1H), 7.06–7.09(m, 2H), 7.16(s, 1H), 7.26(s, 1H) IR(KBr) 3406, 2933, 1524, 1490, 1397, 1270, 1241, 1116, 1075, 1069, 811, 773cm⁻¹

TABLE 230 I-1162 mp 81–83° C. ¹H NMR(CDCl₃) δ 1.76(s, 6H), 1.79(s, 3H), 1.81(s, 3H), 3.50(s, 3H), 3.75(s, 3H), 3.80(d, J=6.6Hz, 2H), 4.36(brs, 1H), 4.61(d, J=6.9Hz, 2H), 5.39(t, J=6.3Hz, 1H), 5.53(t, J=6.6Hz, 1H), 5.68(brs, 1H), 5.90(brs, 1H), 6.43(s, 1H), 6.73(d, J=8.4Hz, 1H), 6.95(s, 1H), 7.05(s, 1H), 7.26(d, J=0.9Hz, 1H), 7.47(dd, J=2.1, 8.4Hz, 1H), 7.59(d, J=2.1Hz, 1H) IR(KBr) 3484, 2931, 1607, 1525, 1488, 1310, 1243, 1114, 1070, 1009, 808cm⁻¹ I-1163 mp 87–89° C. ¹H NMR(CDCl₃) δ 2.81(s, 3H), 3.60(s, 3H), 3.77(s, 3H), 3.98(d, J=6.3Hz, 2H), 4.80(d, J=6.3Hz, 2H), 6.07(t, J=6.0Hz, 1H), 6.25(t, J=6.3Hz, 1H), 6.46–6.53(m, 2H), 6.86(s, 1H), 7.05–7.38(m, 4H) IR(KBr) 3411, 2937, 1628, 1527, 1482, 1364, 1233, 1176, 1077, 960, 879, 792, 524cm⁻¹ I-1164 amorphous ¹H NMR(CDCl₃) δ 2.68(s, 3H), 3.13(s, 3H), 3.43(s, 3H), 3.54(s, 3H), 3.80(s, 3H), 5.19(s, 2H), 6.87(s, 1H), 7.16(d, J=8.7Hz, 1H), 7.32–7.49(m, 9H), 7.69(d, J=8.4Hz, 2H) IR(KBr) 1698, 1522, 1482, 1367, 1080, 1014, 947, 815, 795cm⁻¹ I-1165 foam ¹H NMR(CDCl₃) δ 1.47(s, 3H), 1.72(s, 3H), 1.77(s, 3H), 1.81(s, 3H), 2.71(s, 3H), 3.24(s, 3H), 3.51(s, 3H), 3.80(s, 3H), 4.37(d, J=7.8Hz, 2H), 4.64(d, J=6.6Hz, 2H), 5.29(t, J=7.8Hz, 1H), 5.50(t, J=6.6Hz, 1H), 6.88(s, 1H), 7.09(d, J=8.4Hz, 1H), 7.27(d, J=8.7Hz, 2H), 7.35(dd, J=8.4, 2.3Hz, 1H), 7.39(d, J=2.3Hz, 1H), 7.66(d, J=8.7Hz, 2H) IR(KBr) 1696, 1521, 1482, 1366, 1177, 1080, 972, 946, 814, 795cm⁻¹ I-1166 mp 135–136° C. ¹H NMR(CDCl₃) δ 1.77(s, 3H), 1.81(s, 3H), 2.71(s, 3H), 3.24(s, 3H), 3.54(s, 3H), 3.80(s, 3H), 4.64(d, J=6.7Hz, 2H), 5.50(t, J=6.7Hz, 1H), 6.87(s, 1H), 7.10(d, J=8.4Hz, 1H), 7.34(d, J=8.1Hz, 2H), 7.35(dd, J=8.4, 2.2Hz, 1H), 7.39(d, J=2.2Hz, 1H), 7.69(d, J=8.1Hz, 2H) IR(KBr) 1702, 1522, 1481, 1362, 1275, 1150, 1081, 1014, 978, 817, 793cm⁻¹

TABLE 231 I-1167 mp 169–171° C. ¹H NMR(DMSO-d₆) δ 1.71(s, 3H), 1.72(s, 6H), 1.76(s, 3H), 3.31(s, 3H), 3.63(s, 3H), 3.64(m, 2H), 4.54(d, J=6.8Hz, 2H), 5.29(t, J=7.5Hz, 1H), 5.49(t, J=6.8Hz, 1H), 5.75(t, J=8.1Hz, 1H), 6.37(s, 1H), 6.63(d, J=8.4Hz, 2H), 6.64(dd, J=8.1, 2.0Hz, 1H), 6.73(d, J=2.0Hz, 1H), 6.88(d, J=8.4Hz, 2H), 7.37(d, J=8.4Hz, 2H), 8.41(s, 1H), 8.70(s, 1H) IR(KBr) 3473, 3276, 1608, 1523, 1491, 1310, 1252, 1190, 1112, 1072, 934, 824, 776cm⁻¹ I-1168 mp 159–160° C. ¹H NMR(DMSO-d₆) δ 1.72(s, 3H), 1.76(s, 3H), 3.31(s, 3H), 3.64(s, 3H), 4.54(d, J=6.8Hz, 2H), 5.49(t, J=6.8Hz, 1H), 5.76(br s, 1H), 6.37(s, 1H), 6.61(d, J=8.4Hz, 2H), 6.64(dd, J=8.1, 2.0Hz, 1H), 6.73(d, J=2.0Hz, 1H), 6.88(d, J=8.1Hz, 1H), 7.39(d, J=8.4Hz, 2H), 7.37(d, J=8.4Hz, 2H), 8.42(br s, 1H), 8.70(br s, 1H) IR(KBr) 3458, 3332, 1609, 1524, 1492, 1411, 1393, 1295, 1234, 1107, 1071, 1012, 994, 781cm⁻¹ I-1169 mp 183–184° C. ¹H NMR(CDCl₃) δ 1.76(d, J=0.6Hz, 3H), 1.82(s, 3H), 3.13(s, 3H), 3.48(s, 3H), 3.76(s, 3H), 4.63(d, J=6.9Hz, 2H), 5.53(m, 1H), 5.72(s, 1H), 5.83(s, 1H), 6.46(s, 1H), 6.93(dd, J=1.8, 8.4Hz, 1H), 6.98(d, J=8.4Hz, 1H), 7.04(d, J=1.8Hz, 1H), 7.82–7.89(m, 2H), 8.00–8.06(m, 2H) IR(KBr) 3445, 1593, 1499, 1482, 1461, 1387, 1311, 1278, 1245, 1189, 1146, 1111, 1086, 1068, 1010, 997, 942, 766cm⁻¹ I-1170 mp 178–179° C. ¹H NMR(CDCl₃) δ 1.76(s, 3H), 1.82(s, 3H), 2.80(s, 3H), 3.47(s, 3H), 3.76(s, 3H), 4.62(d, J=7.2Hz, 2H), 5.53(m, 1H), 5.72(s, 1H), 5.86(s, 1H), 6.47(s, 1H), 6.94(dd, J=1.8, 8.1Hz, 1H), 6.98(d, J=8.1Hz, 1H), 7.05(d, J=1.8Hz, 1H), 7.72–7.77 (m, 2H), 7.79–7.85(m, 2H) IR(KBr) 3420, 1587, 1527, 1482, 1449, 1430, 1416, 1390, 1357, 1290, 1240, 1214, 1198, 1135, 1115, 1073, 1019, 998, 975, 962, 937, 831cm⁻¹

TABLE 232 I-1171 mp 136–139° C. ¹H NMR(CDCl₃) δ 1.73(s, 3H), 1.77(s, 3H), 2.99(s, 6H), 3.71(d, J=6.6Hz, 2H), 3.76(s, 3H), 3.78(s, 3H), 5.32–5.37(m, 1H), 6.36–6.46(m, 2H), 6.79–6.84(m, 2H), 6.89(s, 1H), 6.95(s, 1H), 7.18–7.24(m, 1H), 7.47–7.52(m, 2H) IR(KBr) 3600–2800(br), 1626, 1609, 1531, 1493, 1460, 1444, 1388, 1345, 1232, 1207, 1173, 1124, 1050, 1028cm⁻¹ I-1172 mp 113–114° C. ¹H NMR(CDCl₃) δ 3.00(s, 6H), 3.77(s, 3H), 3.78(s, 3H), 6.78–6.84(m, 2H), 6.88(s, 1H), 6.98(s, 1H), 7.31(dd, J=2.1, 8.4Hz, 1H), 7.43–7.53(m, 3H), 7.58(dd, J=1.8, 11.1Hz, 1H) IR(KBr) 3600–2800(br), 1711, 1609, 1533, 1493, 1464, 1390, 1212, 1181, 1162, 1052, 1027cm⁻¹ I-1173 mp 141–143° C. ¹H NMR(CDCl₃) δ 1.75(d, J=0.9Hz, 3H), 1.78(d, J=0.9Hz, 3H), 2.99(s, 6H), 3.50(s, 3H), 3.74(s, 3H), 3.78(d, J=6.6Hz, 2H), 3.93(br, 1H), 5.35–5.40(m, 1H), 5.86(s, 1H), 6.44(s, 1H), 6.74–6.86(m, 3H), 7.30–7.38(m, 4H) IR(KBr) 3600–2800(br), 1625, 1611, 1530, 1491, 1458, 1444, 1400, 1348, 1333, 1250, 1217, 1103, 1075cm⁻¹ I-1174 mp 226–228° C. ¹H NMR(CDCl₃) δ 3.93(s, 3H), 4.95(s, 1H), 5.21(s, 2H), 6.90–6.94(m, 2H), 6.96(s, 1H), 6.97(s, 1H), 7.03(d, J=0.9Hz, 1H), 7.30–7.49(m, 1H) IR(KBr) 3600–2800(br), 1608, 1589, 1520, 1471, 1446, 1384, 1358, 1270, 1250, 1238, 1210, 1172, 1141, 1093, 1031, 997cm⁻¹ I-1175 mp 143–145° C. ¹H NMR(CDCl₃) δ 3.21(s, 3H), 3.93(s, 3H), 5.22(s, 2H), 6.97(s, 2H), 7.03(s, 1H), 7.30–7.55(m, 11H) IR(KBr) 3600–2800(br), 1602, 1517, 1468, 1368, 1348, 1248, 1210, 1176, 1151, 1095, 1038, 989cm⁻¹

TABLE 233 I-1176 mp 98–100° C. ¹H NMR(CDCl₃) δ 1.76(s, 3H), 1.79(s, 3H), 3.21(s, 3H), 3.91(s, 3H), 4.65(d, J=6.9Hz, 2H), 5.53–5.58(m, 1H), 6.94–7.03 (m, 3H), 7.23–7.41(m, 2H), 7.45(s, 1H), 7.49(s, 1H), 7.51–7.56(m, 1H) IR(KBr) 3600–2800(br), 1604, 1583, 1519, 1470, 1449, 1365, 1250, 1202, 1177, 1151, 1095, 1041, 972cm⁻¹ I-1177 mp 118–120° C. ¹H NMR(CDCl₃) δ 1.76(s, 3H), 1.79(s, 3H), 3.91(s, 3H), 4.64(d, J=6.9Hz, 2H), 5.53–5.58(m, 1H), 6.88–7.02(m, 5H), 7.23–7.37(m, 2H), 7.44(s, 1H), 7.46(s, 1H) IR(KBr) 3600–2800(br), 1626, 1609, 1526, 1490, 1429, 1253, 1187cm⁻¹ I-1178 mp 161–164° C. ¹H NMR(CDCl₃) δ 3.00(s, 3H), 3.79(s, 3H), 3.80(s, 3H), 6.78–6.83(m, 2H), 6.90(s, 1H), 6.97(s, 1H), 7.47–7.52(m, 2H), 7.71(d, J=1.8Hz, 1H), 8.37(d, J=8.7Hz, 1H), 8.46(br s, 1H) IR(KBr) 3600–2800(br), 1716, 1613, 1532, 1505, 1487, 1463, 1384, 1357, 1280, 1195, 1172, 1059, 1033cm⁻¹ I-1179 mp 135–137° C. ¹H NMR(CDCl₃) δ 1.74(s, 3H), 1.78(s, 3H), 3.00(s, 6H), 3.78(s, 3H), 3.79(s, 3H), 4.29(d, J=6.6Hz, 1H), 5.35–5.40(m, 1H), 6.71(d, J=8.4Hz, 1H), 6.80–6.83(m, 2H), 6.90(s, 1H), 6.94(s, 1H), 7.38–7.42(m, 1H), 7.48–7.56(m, 3H) IR(KBr) 3600–2800(br), 1612, 1532, 1495, 1460, 1444, 1385, 1365, 1273, 1257, 1203, 1059, 1039, 1029cm⁻¹ I-1180 ¹H NMR(CDCl₃) δ 1.57(d, J=6.3Hz, 3H), 2.26(s, 3H), 2.28(s, 3H), 5.18(s, 2H), 5.22(q, J=6.3Hz, 1H), 7.02(d, J=8.4Hz, 1H), 7.12(s, 1H), 7.15(s, 1H), 7.23(d.d, J=8.4 & 2.1Hz, 1H), 7.30–7.51(m, 10H) IR(KBr) 3557, 1605, 1486, 1370, 1235, 1177, 1149, 1078, 1017cm⁻¹ I-1181 ¹H NMR(CDCl₃) δ 1.66(s, 6H), 2.27(s, 3H), 2.28(s, 3H), 3.20(s, 3H), 4.22(s, 1H), 5.22(s, 2H), 7.06(d, J=8.4Hz, 1H), 7.12(s, 1H), 7.14(s, 1H), 7.23(d.d, J=8.4 & 2.1Hz, 1H), 7.30–7.51(m, 10H) IR(KBr) 3544, 3441, 1604, 1512, 1485, 1367, 1222, 1173, 1149cm⁻¹

TABLE 234 I-1182 ¹H NMR(CDCl₃) δ 1.28(t, J=7.2Hz, 3H), 2.26(s, 3H), 2.28(s, 3H), 2.70(q, J=7.2Hz, 2H), 3.20(s, 3H), 4.73(s, 1H), 6.82 (d, J=8.4Hz, 1H), 7.03–7.11(m, 2H), 7.14(s, 1H), 7.15(s, 1H), 7.29–7.46(m, 4H) IR(KBr) 3510, 1605, 1515, 1488, 1369, 1263, 1177, 1147, 1117cm⁻¹ I-1183 ¹H NMR(CDCl₃) δ 1.29(d, J=6.9Hz, 6H), 2.27(s, 3H), 2.28(s, 3H), 3.20(s, 3H), 3.27(qintet, J=6.9Hz, 1H), 4.76(s, 1H), 6.81(d, J=7.8Hz, 1H), 7.07(d.d, J=7.8 & 2.1Hz, 1H), 7.11(s, 1H), 7.15(s, 1H), 7.20(d, J=2.1Hz, 1H), 7.34(d, J=8.7Hz, 2H), 7.42(d, J=8.7Hz, 2H), IR(KBr) 3511, 1606, 1484, 1356, 1174, 1151cm⁻¹ I-1184 ¹H NMR(CDCl₃) δ 1.23(t, J=8.1Hz, 3H), 1.77(s, 3H), 1.82(s, 3H), 2.26(s, 3H), 2.29(s, 3H), 2.70(q, J=8.1Hz, 2H), 3.20 (s, 3H), 4.58(d, J=6.6Hz, 2H), 5.48–5.57(m, 1H), 6.90(d, J=7.8Hz, 1H), 7.08–7.13(m, 2H), 7.16(s, 2H), 7.23–7.47(m, 4H) IR(KBr) 1605, 1485, 1369, 1352, 1236, 1201, 1174, 1150, 1133, 1008cm⁻¹ I-1185 ¹H NMR(CDCl₃) δ 1.23(t, J=7.5Hz, 3H), 1.76(s, 3H), 1.81(s, 3H), 2.27(s, 3H), 2.29(s, 3H), 2.70(q, J=7.5Hz, 2H), 4.57(d, J=6.6Hz, 2H), 4.79(brs, 1H), 5.49–5.58(m, 1H), 6.83–6.92(m, 3H), 7.08–7.19(m, 4H), 7.27(.d, J=8.4Hz, 2H) IR(KBr) 3529, 1608, 1519, 1487, 1241, 1136, 1024cm⁻¹ I-1186 ¹H NMR(CDCl₃) δ 1.23(d, J=1.8Hz, 6H), 1.76(s, 3H), 1.82(s, 3H), 2.27(s, 3H), 2.29(s, 3H), 3.20(s, 3H), 3.40(quintet, J=1.8Hz, 1H), 4.58(d, J=6.6Hz, 2H), 5.48–5.59(m, 1H), 6.90(d, J=7.8Hz, 1H), 7.10–7.44(m, 8H) IR(KBr) 1602, 1468, 1369, 1232, 1174, 1151cm⁻¹ I-1187 ¹H NMR(CDCl₃) δ 1.24(d, J=6.9Hz, 6H), 1.76(s, 3H), 1.81(s, 3H), 2.27(s, 3H), 2.29(s, 3H), 3.40(quintet, J=6.9Hz, 1H), 4.58(d, J=6.6Hz, 2H), 4.79(broad, s., 1H), 5.50–5.57(m, 1H), 6.84–6.93(m, 3H), 7.09–7.16(m, 3H), 7.00–7.28 (m, 3H) IR(KBr) 3265, 1607, 1519, 1486, 1448, 1383, 1232, 1170cm⁻¹

TABLE 235 I-1188 ¹H NMR(CDCl₃) δ 1.31(d, J=6.9Hz, 6H), 1.44(s, 3H), 1.67(s, 3H), 2.97(quintet, J=6.9Hz, 1H), 3.78(s, 3H), 3.80(s, 3H), 3.92(s, 3H), 4.20–4.30(broad, 1H), 5.17–5.30(m, 1H), 6.96(s, 1H), 6.99(s, 1H), 7.07–7.35(m, 5H), 7.52(d, J=8.1Hz, 2H) IR(KBr) 3422, 1601, 1529, 1492, 1462, 1378, 1341, 1257, 1203, 1138, 1028cm⁻¹ I-1189 ¹H NMR(CDCl₃) δ 2.67(s, 3H), 3.13(s, 3H), 3.57(s, 3H), 3.79(s, 3H), 5.19(s, 2H), 6.84(s, 1H), 7.15(d, J=9.0Hz, 1H), 7.31–7.50(m, 8H), 7.55(d.d, J=12.0 & 1.8Hz, 1H), 8.34–8.41(m, 1H) IR(KBr) 3428, 1740, 1601, 1535, 1482, 1366, 1292, 1238, 1177, 1164, 1112, 1079, 1013cm⁻¹ I-1190 ¹H NMR(CDCl₃) δ 1.48(s, 3H), 1.70(s, 3H), 1.77(s, 3H), 1.81(s, 3H), 2.70(s, 3H), 3.24(s, 3H), 3.55(s, 3H), 3.81(s, 3H), 4.09–4.20(m, 1H), 4.53–4.68(m, 3H), 5.18–5.30(m, 1H), 5.43–5.54(m, 1H), 6.86(s, 1H), 7.06–7.51(m, 6H) IR(KBr) 1702, 1521, 1482, 1367, 1204, 1177, 1115, 1080cm⁻¹ I-1191 ¹H NMR(CDCl₃) δ 1.75(s, 6H), 1.78(s, 3H), 1.82(s, 3H), 3.49(s, 3H), 3.74(s, 3H), 3.79(d, J=6.3Hz, 2H), 4.61(d, J=6.6Hz, 2H), 5.32–5.43(m, 1H), 5.49–5.57(m, 1H), 5.68(s, 1H), 5.90(s, 1H), 6.44(s, 1H), 6.74–6.85(m, 1H), 6.95(s, 2H), 7.05(s, 1H), 7.29–7.38(m, 2H) IR(KBr) 3527, 1624, 1530, 1491, 1248, 1221, 1197, 1125, 1105, 1072cm⁻¹ I-1192 ¹H NMR(CDCl₃) δ 1.75(s, 3H), 1.78(s, 3H), 3.49(s, 3H), 3.73(s, 3H), 3.78(d, J=6.9Hz, 2H), 5.32–5.43(m, 1H), 6.44(s, 1H), 6.73–6.97(m, 4H), 7.25–7.37(m, 2H) IR(KBr) 3551, 3437, 3310, 1607, 1529, 1491, 1463, 1402, 1362, 1269, 1255, 1184, 1099, 1070, 1013cm⁻¹ I-1193 ¹H NMR(CDCl₃) δ 2.28(s, 3H), 2.30(s, 3H), 3.00(s, 6H), 5.16(s, 2H), 5.69(s, 1H), 6.80(d, J=8.7Hz, 2H), 6.84(d.d, J=8.1 & 2.1Hz, 1H), 6.98(d, J=8.1Hz, 1H), 6.99(d, J=2.1Hz, 1H), 7.12(s, 1H), 7.13(s, 1H), 7.27(d, J=8.7Hz, 2H), 7.34–7.50(m, 5H) IR(KBr) 1605, 1525, 1490, 1417, 1242, 1199, 1127, 1006cm⁻¹

TABLE 236 I-1194 mp 174–175° C. ¹H NMR(CDCl₃) δ 3.48(s, 3H), 3.78(s, 3H), 4.41(s, 4H), 5.17(s, 2H), 5.71(s, 1H), 5.88(s, 1H), 6.48(s, 1H), 6.94–7.50(m, 18H), 7.86(ABq, J=8.4Hz, 4H) IR(KBr) 3463, 3409, 1588, 1519, 1482, 15455, 1417, 1385, 1321, 1285, 1247, 1154, 1112, 1096, 1067, 1015cm⁻¹ I-1195 mp 165–167° C ¹H NMR(CDCl₃) δ 2.68(s, 3H), 3.14(s, 3H), 3.56(s, 3H), 3.81(s, 3H), 4.40(s, 4H), 5.20(s, 2H), 6.86(s, 1H), 7.09–7.50(m, 18H), 7.79(ABq, J=8.1Hz, 4H) IR(KBr) 3434, 2938, 1606, 1596, 1518, 1478, 1455, 1368, 1335, 1293, 1268, 1239, 1174, 1157, 1118, 1079cm⁻¹ I-1196 mp 176–178° C. ¹H NMR(CDCl₃) δ 1.58(s, 3H), 1.66(s, 3H), 1.77(s, 3H), 1.81(s, 3H), 2.71(s, 3H), 3.24(s, 3H), 3.55(s, 3H), 3.64(m, 2H), 3.80(s, 3H), 4.28(t, J=6.0Hz, 1H), 4.64(d, J=6.9Hz, 2H), 5.10(m, 1H), 5.49(m, 1H), 6.86(s, 1H), 7.10(d, J=8.4Hz, 1H), 7.35(dd, J=2.1, 8.4Hz, 1H), 7.39(d, J=2.1Hz, 1H), 7.87(ABq, J=8.7Hz, 4H) IR(KBr) 3434, 3321, 2939, 1517, 1477, 1366, 1325, 1292, 1269, 1240, 1176, 1156, 1120, 1077cm⁻¹ I-1197 mp 180–181° C. ¹H NMR(DMSO) δ 1.74(s, 3H), 1.77(s, 3H), 2.87(s, 3H), 3.36(s, 3H), 3.51(s, 3H), 3.79(s, 3H), 4.68(d, J=6.6Hz, 2H), 5.48(m, 1H), 7.10(s, 1H), 7.28–7.30(m, 3H), 7.45(bs, 2H), 7.87(ABq, J=8.7Hz, 4H) IR(KBr) 3340, 3238, 2939, 1598, 1518, 1481, 1362, 1333, 1291, 1270, 1239, 1172, 1161, 1120, 1076, 1007cm⁻¹ I-1198 oil ¹H NMR(CDCl₃) δ 1.45(s, 3H), 1.66(s, 3H), 1.87(s, 3H), 2.24(s, 3H), 2.27(s, 3H), 2.30(s, 3H), 3.84(s, 3H), 3.92(s, 3H), 3.95–4.03(m, 1H), 4.50–4.58(m, 1H), 5.22–5.29(m, 1H), 6.87–6.99(m, 4H), 7.09–7.17(m, 3H), 7.80(s, 1H), 8.34–8.42(m, 1H) IR(CHCl₃) 3673, 3021, 1685, 1639, 1525, 1495, 1406, 1237, 1128, 1037cm⁻¹

TABLE 237 I-1199 mp 177–179° C. ¹H NMR(CDCl₃) δ 1.45(s, 6H), 1.66(s, 6H), 1.87(s, 6H), 2.29(s, 6H), 3.85(s, 6H), 3.95–4.04(m, 2H), 4.50–4.59(m, 2H), 5.23–5.29(m, 2H), 6.90–6.95(m, 4H), 7.10–7.15(m, 2H), 7.19(s, 2H) IR(KBr) 2929, 1661, 1492, 1405, 1288, 1214, 1030, 869, 829cm⁻¹ I-1200 mp 224–226° C. ¹H NMR(CDCl₃) δ 2.88(s, 3H), 3.22(s, 3H), 3.54(s, 3H), 3.78(s, 3H), 6.43(s, 1H), 6.85(s, 1H), 7.01(d, J=8.4Hz, 1H), 7.20(dd, J=2.1, 8.4Hz, 1H), 7.35–7.42(m, 2H), 7.65–7.72(m, 2H), 7.96(d, J=2.1Hz, 1H), 8.96(s, 1H) IR(KBr) 3441, 3370, 3024, 2938, 1729, 1508, 1481, 1365, 1177, 1148, 1085, 884, 798, 524cm⁻¹ I-1201 powder ¹H NMR(CDCl₃) δ 1.77(s, 3H), 1.82(s, 3H), 2.80(s, 3H), 3.21(s, 3H), 3.56(s, 3H), 3.79(s, 3H), 4.67(d, J=6.6Hz, 2H), 5.46–5.51(m, 1H), 6.84(s, 1H), 7.05(d, J=8.1Hz, 1H), 7.22–7.26(m, 1H), 7.36–7.41(m, 2H), 7.67–7.71(m, 2H), 8.35(d, J=1.8Hz, 1H), 9.24(s, 1H) IR(KBr) 3385, 2937, 1718, 1532, 1479, 1362, 1175, 1152, 1078, 973, 876, 797, 526cm⁻¹ I-1202 mp 260–262° C. ¹H NMR(DMSO) δ 2.27(s, 6H), 3.87(s, 6H), 7.00(dd, J=1.8, 8.1Hz, 2H), 7.10(d, J=1.8Hz, 2H), 7.21(s, 2H), 7.48(d, J=8.1Hz, 2H), 10.73(s, 2H) IR(KBr) 3392, 3008, 1719, 1600, 1542, 1413, 1297, 1158, 1032, 905, 627cm⁻¹ I-1203 mp 143–144° C. ¹H NMR(CDCl₃) δ 1.76(s, 3H), 1.82(s, 3H), 3.61(s, 3H), 3.67(s, 3H), 3.73(s, 3H), 3.87(s, 3H), 4.62(d, J=6.9Hz, 2H), 5.50–5.58(m, 1H), 5.66(s, 1H), 6.86–7.02(m, 5H), 7.54(d, J=9Hz, 2H) IR(KBr) 3494, 2935, 1673, 1609, 1584, 1519, 1479, 1456, 1389, 1284, 1249, 1178, 1109, 1081, 1016, 829, 798cm⁻¹

TABLE 238 I-124 mp 90–91° C. ¹H NMR(CDCl₃) δ 1.72(s, 3H), 1.79(s, 3H), 2.26(s, 6H), 4.69(d, J=7.2Hz, 2H), 4.9–5.0(brs, 1H), 5.57(t, J=7.2Hz, 1H), 6.85–7.0(m, 4H), 7.10(d, J=8.7Hz, 2H), 7.23(d, J=8.7Hz, 2H) IR(KBr) 3253, 3013, 2979, 2928, 1676, 1584, 1521, 1492, 1232, 1034, 950, 848, 825cm⁻¹ I-1205 mp 131–132° C. ¹H NMR(CDCl₃) δ 1.73(s, 3H), 1.79(s, 3H), 3.43(s, 3H), 3.76(s, 3H), 4.68(d, J=6.9Hz, 2H), 4.9–5.1(brs, 1H), 5.58(t, J=7.2Hz, 1H), 6.09(brs, 1H), 6.44(s, 1H), 6.92(d, J=8.4Hz, 2H), 7.0–7.1(m, 2H), 7.52(d, J=8.4Hz, 2H) IR(KBr) 3428, 2951, 2932, 1671, 1611, 1523, 1491, 1402, 1233, 1111, 1077, 1027, 969, 833cm⁻¹ I-1206 mp 191–192° C. ¹H NMR(CDCl₃) δ 2.15(s, 6H), 3.22(s, 3H), 3.87(s, 3H), 5.18(AB q, J=12.0Hz, 2H), 6.74(dd, J=2.1, 8.1Hz, 1H), 6.78 (d, J=2.1Hz, 1H), 6.93(d, J=8.1Hz, 1H), 7.24(s, 1H), 7.30–7.50(m, 9H) IR(KBr) 1528, 1479, 1453, 1364, 1326, 1262, 1243, 1223, 1209, 1200, 1176, 1152, 1137, 963, 870, 846, 754cm⁻¹ I-1207 mp 108–109° C. ¹H NMR(CDCl₃) δ 1.77(s, 3H), 1.82(d, J=0.6Hz, 3H), 2.27(s, 3H), 2.28(s, 3H), 4.56(d, J=6.6Hz, 2H), 4.89(s, 1H), 5.54(m, 1H), 6.86–6.92(m, 2H), 6.94–7.00(m, 2H), 7.12(s, 1H), 7.13(s, 1H), 7.22–7.27(m, 2H), 7.27–7.31(m, 2H) IR(KBr) 3349, 1608, 1520, 1488, 1439, 1383, 1287, 1263, 1235, 1175, 999, 979cm⁻¹ I-1208 mp 194–195° C. ¹H NMR(CDCl₃) δ 2.14(s, 3H), 2.16(s, 3H), 3.87(s, 3H), 4.97(s, 1H), 5.17(AB q, J=12.6Hz, 2H), 6.74(dd, J=2.1, 8.1Hz, 1H), 6.79(d, J=2.1Hz, 1H), 6.88–6.93(m, 2H), 6.93(d, J=8.1Hz, 1H), 7.17–7.22(m, 2H), 7.24(s, 1H), 7.29–7.49(m, 5H) IR(KBr) 3408, 1611, 1526, 1479, 1463, 1455, 1382, 1263, 1242, 1225, 1212, 1143, 997, 751cm⁻¹

TABLE 239 I-1209 mp 183–184° C. ¹H NMR(CDCl₃) δ 2.03(s, 3H), 2.07(s, 3H), 3.19(s, 3H), 3.80(br s, 2H), 3.89(s, 3H), 5.21(s, 2H), 6.63(s, 1H), 6.77(dd, J=2.1, 8.1Hz, 1H), 6.83(d, J=2.1Hz, 1H), 7.02(d, J=8.1Hz, 1H), 7.29–7.52(m, 9H) IR(KBr) 3481, 3391, 1610, 1511, 1482, 1370, 1240, 1212, 1197, 1173, 1153, 1137, 1024, 1007, 870, 844cm⁻¹ I-1210 mp 133–134° C. ¹H NMR(CDCl₃) δ 1.75(s, 3H), 1.80(s, 3H), 2.16(s, 3H), 2.17(s, 3H), 3.22(s, 3H), 3.85(s, 3H), 4.61(d, J=6.9Hz, 2H), 5.55(m, 1H), 6.74–6.79(m, 2H), 6.92(d, J=8.7Hz, 1H), 7.24(s, 1H), 7.39(s, 4H) IR(KBr) 1529, 1516, 1478, 1371, 1353, 1328, 1263, 1242, 1201, 1176, 1150, 975, 866, 846, 787cm⁻¹ I-1211 mp 243–244° C. ¹H NMR(DMSO-d₆) δ 1.91(s, 3H), 1.96(s, 3H), 3.77(s, 3H), 4.05(br s, 2H), 5.12(s, 2H), 6.40(s, 1H), 6.71(dd, J=1.8, 8.1Hz, 1H), 6.77–6.84(m, 3H), 7.06–7.12(m, 2H), 7.16(d, J=8.1Hz, 1H), 7.32–7.52(m, 5H), 9.38(s, 1H) IR(KBr) 3378, 3289, 1609, 1586, 1518, 1483, 1454, 1402, 1267, 1236, 1207, 1171, 1136, 1024, 853, 835, 816, 753, 730, 695cm⁻¹ I-1212 mp 195–196° C. ¹H NMR(CDCl₃) δ 1.75(s, 3H), 1.79(s, 3H), 2.15(s, 3H), 2.16(s, 3H), 3.85(s, 3H), 4.61(d, J=6.9Hz, 2H), 4.97(s, 1H), 5.55(m, 1H), 6.76–6.79(m, 2H), 6.89–6.94(m, 3H), 7.18–7.23(m, 2H), 7.24(s, 1H) IR(KBr) 3462, 1611, 1519, 1479, 1459, 1431, 1379, 1271, 1240, 1228, 1211, 1137, 983, 835cm⁻¹ I-1213 IR(KBr) 3275, 1494, 1462, 1444, 1387, 1371, 1232, 1212, 1183, 1141cm⁻¹ I-124 mp 106–108° C. ¹H NMR(CDCl₃) δ 2.24(s, 3H), 3.79(s, 3H), 4.72(br, 1H), 5.20(s, 2H), 6.72–7.18(m, 8H), 7.36–7.50(m, 6H) IR(CHCl₃) 3596, 1610, 1523, 1493, 1465, 1455, 1388, 1318, 1298, 1262, 1173, 1127, 1038, 834cm⁻¹

TABLE 240 I-1215 mp 108–110° C. ¹H NMR(CDCl₃) δ 1.77(s, 3H), 1.82(s, 3H), 2.25(s, 3H), 3.79(s, 3H), 4.63–4.65(d, J=7.2Hz, 2H), 5.56(s, 2H), 6.81(s, 1H), 6.87–7.18(m, 6H), 7.44–7.47(m, 2H) IR(CHCl₃) 3596, 2937, 1610, 1523, 1493, 1465, 1446, 1387, 1297, 1261, 1173, 1125, 1038, 993, 834cm⁻¹ I-1216 mp 121–122° C. ¹H NMR(CDCl₃) δ 2.24(s, 3H), 3.79(s, 3H), 4.78–4.80(d, J=6.9Hz, 2H), 6.24(t, J=6.9Hz, 1H), 6.80(s, 1H), 6.87–7.19 (m, 6H), 7.43–7.48(m, 2H) IR(CHCl₃) 3596, 1612, 1523, 1493, 1464, 1389, 1300, 1259, 1173, 1127, 1038, 886, 834cm⁻¹ I-1217 mp 163–165° C. ¹H NMR(CDCl₃) δ 2.26(s, 3H), 2.28(s, 3H), 4.78(br s, 1H), 4.78(d, J=6.5Hz, 2H), 5.60(s, 1H) 6.23(t, J=6.5Hz, 1H), 6.83–6.92(m, 4H), 6.99(d, J=2.1Hz, 1H), 7.10(s, 1H), 7.11(s, 1H), 7.22–7.27(m, 2H) IR(CHCl₃) 3597, 3548, 3027, 3010, 1613, 1588, 1522, 1490, 1218, 1208, 1171cm⁻¹ I-1218 foam ¹H NMR(CDCl₃) δ 2.37(s, 3H), 3.39(s, 3H), 3.73(s, 3H), 5.15(s, 2H), 5.68(s, 1H), 5.92(s, 1H), 6.46(s, 1H), 6.71(dd, J=3.7, 0.7Hz, 1H), 6.96(dd, J=8.4, 2.1Hz, 1H), 7.03(d, J=8.4Hz, 1H), 7.09(d, J=2.1Hz, 1H), 7.26(dd, J=8.6, 0.7Hz, 2H), 7.37–7.45(m, 5H), 7.60(dd, J=8.7, 1.5Hz, 1H), 7.61(d, J=3.7Hz, 1H), 7.78(d, J=1.5Hz, 1H), 7.82(d, J=8.6Hz, 1H), 8.05(d, J=8.7Hz, 1H) IR(KBr) 3476, 1457, 1371, 1254, 1107, 1131, 1107, 1011, 814, 685, 581cm⁻¹ I-1219 mp 217–219° C. ¹H NMR(CDCl₃) δ 2.37(s, 3H), 2.69(s, 3H), 3.12(s, 3H), 3.47(s, 3H), 3.76(s, 3H), 5.18(s, 2H), 6.71(d, J=3.8Hz, 1H), 6.86(s, 1H), 7.15(d, J=8.4Hz, 1H), 7.26(d, J=8.7Hz, 2H), 7.32–7.48(m, 7H), 7.56(dd, J=8.7, 1.8Hz, 1H), 7.61(d, J=3.8Hz, 1H), 7.78(d, J=1.8Hz, 1H), 7.82(d, J=8.7Hz, 1H), 8.05(d, J=8.7Hz, 1H) IR(KBr) 1366, 1174, 1079, 963, 814, 685, 586cm⁻¹

TABLE 241 I-1220 mp 208–210° C. ¹H NMR(CDCl₃) δ 2.37(s, 3H), 2.72(s, 3H), 3.23(s, 3H), 3.47(s, 3H), 3.76(s, 3H), 4.63(d, J=6.6Hz, 2H), 5.49(t, J=6.6Hz, 1H), 6.71(d, J=3.8Hz, 1H), 6.86(s, 1H), 7.09(d, J=8.4Hz, 1H), 7.26(d, J=8.3Hz, 2H), 7.35(dd, J=8.4, 2.1Hz, 1H), 7.40(d, J=2.1Hz, 1H), 7.56(dd, J=8.4, 1.7Hz, 1H), 7.61(d, J=3.8Hz, 1H), 7.78(d, J=1.7Hz, 1H), 7.82(d, J=8.3Hz, 2H), 8.05(d, J=8.7Hz, 1H) IR(KBr) 1466, 1445, 1365, 1174, 1116, 1079, 964, 812, 686, 584cm⁻¹ I-1221 mp 203–205° C. ¹H NMR(CDCl₃) δ 1.76(s, 3H), 1.81(s, 3H), 2.39(s, 3H), 2.69(s, 3H), 2.97(t, J=8.6Hz, 2H), 3.23(s, 3H), 3.50(s, 3H), 3.77(s, 3H), 3.98(t, J=8.6Hz, 2H), 4.63(d, J=6.6Hz, 2H), 5.49(t, J=6.6Hz, 1H), 6.80(s, 1H), 7.08(d, J=8.5Hz, 1H), 7.24–7.28(m, 2H), 7.33(dd, J=8.5, 2.0Hz, 1H), 7.37–7.39(m, 2H), 7.41–7.45(m, 1H), 7.71(d, J=8.4Hz, 1H), 7.73(d, J=8.1Hz, 2H) IR(KBr) 1474, 1362, 1241, 1166, 1079, 975, 808cm⁻¹ I-1222 amorphous ¹H NMR(CDCl₃) δ 1.76(s, 3H), 1.82(s, 3H), 2.39(s, 3H), 2.98(t, J=8.4Hz, 2H), 3.43(s, 3H), 3.73(s, 3H), 3.98(t, J=8.4Hz, 2H), 4.61(d, J=6.6Hz, 2H), 5.53(t, J=6.6Hz, 1H), 5.68(s, 1H), 5.86(s, 1H), 6.40(s, 1H), 6.93–6.95(m, 2H), 7.03–7.05 (m, 1H), 7.23–7.27(m, 2H), 7.35–7.37(m, 1H), 7.45–7.50(m, 1H), 7.71(d, J=8.4Hz, 1H), 7.74(d, J=8.4Hz, 2H) IR(KBr) 3457, 1480, 1354, 1244, 1164, 1099, 978, 817cm⁻¹ I-1223 mp 199–201° C. ¹H NMR(CDCl₃) δ 3.19(s, 3H), 3.72(s, 3H), 3.90(s, 3H), 4.20–4.27(m, 4H), 5.20(s, 2H), 6.53(s, 1H), 6.90–6.99(m, 3H), 7.25–7.65(m, 9H) IR(KBr) 3434, 2938, 1604, 1586, 1522, 1484, 1465, 1432, 1368, 1339, 1326, 1249, 1226, 1203, 1174, 1146, 1136, 1106, 1027cm⁻¹

TABLE 242 I-1224 mp 127–129° C. ¹H NMR(CDCl₃) δ 1.57(s, 3H), 1.65(s, 3H), 1.76(s, 3H), 1.82(s, 3H), 3.46(s, 3H), 3.64(m, 2H), 3.76(s, 3H), 4.30(t, J=5.7Hz, 1H), 4.62(d, J=6.9Hz, 2H), 5.10(m, 1H), 5.53(m, 1H), 5.72(s, 1H), 5.85(s, 1H), 6.47(s, 1H), 6.93(dd, J=1.8, 8.4Hz, 1H), 6.98(d, J=8.4Hz, 1H), 7.05(d, J=1.8Hz, 1H), 7.88(ABq, J=8.7Hz, 4H) IR(KBr) 3478, 3314, 2937, 1585, 1556, 1518, 1501, 1484, 1460, 1417, 1387, 1363, 1328, 1279, 1243, 1228, 1191, 1155, 1129, 1113, 1090, 1068, 1013cm⁻¹ I-1225 mp 162–164° C. ¹H NMR(CDCl₃) δ 3.19(s, 3H), 3.72(s, 3H), 4.19–4.23(m, 4H), 5.18(s, 2H), 6.52(s, 1H), 7.03–7.64(m, 12H) IR(KBr) 3433, 2933, 1523, 1483, 1463, 1435, 1377, 1360, 1269, 1227, 1172, 1149, 1126, 1096cm⁻¹ I-1226 mp 188–190° C. ¹H NMR(DMSO) δ 1.72(s, 3H), 1.75(s, 3H), 3.33(s, 3H), 3.67(s, 3H), 4.55(d, J=6.9Hz, 2H), 5.49(m, 1H), 6.50(s, 1H), 6.66(dd, J=2.1, 8.1Hz, 1H), 6.74(d, J=2.1Hz, 1H), 6.91(d, J=8.1Hz, 1H), 7.42(bs, 2H), 7.85(ABq, J=8.4Hz, 4H), 8.75 (bs, 2H) IR(KBr) 3465, 2937, 1588, 1517, 1500, 1483, 1470, 1446, 1415, 1385, 1340, 1308, 1283, 1246, 1224, 1201, 1186, 1168, 1130, 1116, 1091, 1067, 1011cm⁻¹ I-1227 mp 172–174° C. ¹H NMR(CDCl₃) δ 1.75(s, 3H), 1.78(s, 3H), 3.19(s, 3H), 3.72(s, 3H), 3.87(s, 3H), 4.20–4.27(m, 4H), 4.62(d, J=6.9Hz, 2H), 5.57(m, 1H), 6.54(s, 1H), 6.96(s, 3H), 7.49(ABq, J=8.7Hz, 4H) IR(KBr) 3433, 2937, 1604, 1582, 1522, 1483, 1465, 1432, 1368, 1340, 1326, 1242, 1226, 1218, 1204 1174, 1138, 1107cm⁻¹

TABLE 243 I-1228 mp 169–175° C. ¹H NMR(CDCl₃) δ −0.07–0.02(m, 2H), 0.34–0.42(m, 2H), 0.98(m, 1H), 2.44(s, 3H), 3.20(s, 3H), 3.47(d, J=7.2Hz, 2H), 3.78(s, 3H), 3.91(s, 3H), 5.22(s, 2H), 6.85(s, 1H), 6.91(dd, J=1.8, 8.1Hz, 1H), 6.976(d, J=1.8Hz, 1H), 6.979(d, J=8.1Hz, 1H), 7.26–7.73(m, 9H) IR(KBr) 3447, 2934, 1604, 1518, 1480, 1390, 1362, 1240, 1227, 1175, 1140, 1081cm⁻¹ I-1229 mp 172–174° C. ¹H NMR(CDCl₃) δ 1.74(s, 3H), 1.78(s, 3H), 3.71(s, 3H), 3.87(s, 3H), 4.20–4.25(m, 4H), 4.62(d, J=6.3Hz, 2H), 4.94(bs, 1H), 5.57(m, 1H), 6.55(s, 1H), 6.89–7.50(m, 7H) IR(KBr) 3410, 2933, 1611, 1522, 1484, 1462, 1422, 1371, 1264, 1238, 1224, 1173, 1134, 1103cm⁻¹ I-1230 mp 149–151° C. ¹H NMR(CDCl₃) δ 1.75(s, 3H), 1.81(s, 3H), 3.45(s, 3H), 3.75(s, 3H), 3.87(s, 3H), 4.61(d, J=6.6Hz, 2H), 5.54–5.58(m, 1H), 5.69(s, 1H), 5.91(s, 1H), 6.46(s, 1H), 6.93–7.06(m, 5H), 7.58(d, J=8.7Hz, 2H) IR(KBr) 3501, 2939, 1680, 1609, 1582, 1520, 1487, 1458, 1397, 1284, 1246, 1191, 1179, 1115, 1067, 1015, 940, 822, 794cm⁻¹ I-1231 mp 151–152° C. ¹H NMR(CDCl₃) δ 1.77(d, J=0.6Hz, 3H), 1.81(d, J=0.6Hz, 3H), 2.04(s, 3H), 2.08(s, 3H), 3.20(s, 3H), 3.77(br s, 2H), 3.86(s, 3H), 4.65(d, J=6.6Hz, 2H), 5.58(m, 1H), 6.04(s, 1H), 6.81(dd, J=2.1, 8.7Hz, 1H), 6.81(d, J=2.1Hz, 1H), 7.01 (d, J=8.7Hz, 1H), 7.30–7.36(m, 2H), 7.38–7.43(m, 2H) IR(KBr) 3484, 3393, 2934, 1608, 1511, 1482, 1371, 1239, 1213, 1197, 1173, 1153, 1138, 989, 973, 871, 844, 791cm⁻¹

TABLE 244 I-1232 mp 198–199° C. ¹H NMR(DMSO-d₆) δ 1.72(s, 3H), 1.77(s, 3H), 1.91(s, 3H), 1.95(s, 3H), 3.75(s, 3H), 4.04(s, 2H), 4.55(d, J=6.9Hz, 2H), 5.48(m, 1H), 6.40(s, 1H), 6.69(dd, J=1.8, 8.1Hz, 1H), 6.75(d, J=1.8Hz, 1H), 6.77–6.83(m, 2H), 7.05–7.11(m, 3H), 9.39(s, 1H) IR(KBr) 3375, 3287, 2913, 1609, 1587, 1578, 1518, 1484, 1434, 1403, 1270, 1235, 1207, 1171, 1136, 1032, 1009, 863, 853, 816, 749cm⁻¹ I-1233 mp 198–199° C. ¹H NMR(CDCl₃) δ 1.77(s, 3H), 1.80(s, 3H), 1.91(s, 3H), 2.11(s, 3H), 2.13(s, 3H), 3.20(s, 3H), 3.84(s, 3H), 4.64(d, J=6.6Hz, 2H), 5.58(m, 1H), 6.46(s, 1H), 6.69–6.74(m, 2H), 6.96(d, J=8.4Hz, 1H), 7.11(s, 1H), 7.32–7.38(m, 2H), 7.40–7.46 (m, 2H) IR(KBr) 1651, 1513, 1470, 1448, 1414, 1368, 1330, 1267, 1241, 1214, 1199, 1175, 970, 869cm⁻¹ I-1232 mp 193–194° C. ¹H NMR(CDCl₃) δ 1.77(s, 3H), 1.80(d, J=0.6Hz, 3H), 1.94(s, 3H), 2.11(s, 3H), 2.13(s, 3H), 3.84(s, 3H), 4.64(d, J=6.6Hz, 2H), 5.58(m, 1H), 6.58(s, 1H), 6.70–6.75(m, 2H), 6.85–6.93(m, 2H), 6.96(d, J=8.4Hz, 1H), 7.13(s, 1H), 7.19–7.24(m, 2H) IR(KBr) 3271, 1654, 1611, 1517, 1467, 1448, 1370, 1289, 1262, 1240, 1213, 1177, 1136, 835cm⁻¹ I-1235 mp 114–115° C. ¹H NMR(CDCl₃) δ 1.77(s, 3H), 1.81(s, 3H), 2.27(s, 6H), 3.91(s, 3H), 4.63(d, J=6.6Hz, 2H), 5.56(m, 1H), 5.61(s, 1H), 6.86(dd, J=2.1, 8.4Hz, 1H), 6.86(d, J=2.1Hz, 1H), 6.97(d, J=8.4Hz, 1H), 7.02–7.14(m, 5H) IR(KBr) 3410, 1597, 1521, 1470, 1449, 1415, 1382, 1297, 1276, 1261, 1220, 1122, 1052, 983, 862cm⁻¹

TABLE 245 I-1236 powder ¹H NMR(CDCl₃) δ 3.22(s, 3H), 3.38(s, 3H), 3.46(s, 3H), 3.92(s, 3H), 5.22(s, 2H), 5.76(s, 1H), 6.97–7.09(m, 3H), 7.32–7.51 (m, 9H) IR(KBr) 3448, 2935, 1516, 1455, 1394, 1366, 1352, 1246, 1148, 1076, 1015, 972, 881, 699, 541, 524cm⁻¹ I-1237 mp 169–172° C. ¹H NMR(CDCl₃) δ 2.49(s, 3H), 3.21(s, 3H), 3.47(s, 3H), 3.50(s, 3H), 3.92(s, 3H), 5.23(s, 2H), 6.95–7.04(m, 3H), 7.31–7.49 (m, 9H) IR(KBr) 3009, 2932, 1518, 1459, 1370, 1362, 1250, 1176, 1151, 872, 809, 542, 527cm⁻¹ I-1238 mp 182–184° C. ¹H NMR(CDCl₃) δ 2.67(s, 3H), 3.21(s, 3H), 3.48(s, 3H), 3.50(s, 3H), 3.93(s, 3H), 5.77(s, 1H), 6.98–7.06(m, 3H), 7.38–7.51 (m, 4H) IR(KBr) 3548, 3502, 2938, 1602, 1519, 1389, 1364, 1176, 1159, 1012, 963, 875, 521cm⁻¹ I-1239 mp 132–135° C. ¹H NMR(CDCl₃) δ 1.77(s, 3H), 1.80(s, 3H), 2.62(s, 3H), 3.21(s, 3H), 3.48(s, 3H), 3.51(s, 3H), 3.90(s, 3H), 4.64(d, J=6.6Hz, 2H), 5.51–5.58(m, 1H), 6.97–7.04(m, 3H), 7.37–7.51(m, 4H) IR(KBr) 2936, 1518, 1464, 1375, 1362, 1246, 1175, 1153, 1013, 968, 872, 805, 529cm⁻¹ I-1240 mp 169–172° C. ¹H NMR(CDCl₃) δ 1.76(s, 3H), 1.80(s, 3H), 3.38(s, 3H), 3.47(s, 3H), 3.89(s, 3H), 4.65(d, J=6.6Hz, 2H), 5.06(s, 1H), 5.54–5.61(m, 1H), 5.83(s, 1H), 6.92–7.00(m, 3H), 7.05–7.09(m, 2H), 7.28–7.33(m, 2H) IR(KBr) 3458, 2935, 1611, 1520, 1458, 1392, 1244, 1222, 1015, 828, 803cm⁻¹

TABLE 246 I-1241 mp 170–173° C. ¹H NMR(CDCl₃) δ 1.73(s, 3H), 1.79(s, 3H), 2.55–3.00(m, 3H), 3.21(s, 3H), 3.22–3.80(m, 6H), 4.55–4.63(m, 2H), 5.41–5.47 (m, 1H), 6.83(s, 1H), 7.03–7.70(m, 8H) IR(KBr) 2938, 1686, 1516, 1481, 1378, 1235, 1235, 1179, 1152, 1081, 847, 799, 675, 527cm⁻¹ I-1242 mp 117–118° C. ¹H NMR(CDCl₃) δ 1.77(s, 3H) 1.81(d, J=0.6Hz, 3H), 2.11(s, 3H), 2.19(s, 3H), 3.38(s, 3H), 4.64(d, J=6.9Hz, 2H), 4.75 (br s, 1H), 5.54–5.90(m, 1H), 6.86–6.91(m, 2H), 6.93(s, 1H), 7.10–7.69(m, 3H), 7.20–7.25(m, 2H) IR(CHCl₃) 3596, 3010, 2934, 1675, 1519, 1473, 1262, 1172, 1098cm⁻¹ I-1243 foam ¹H NMR(CDCl₃) δ 3.43(s, 3H), 3.72(s, 3H), 5.03(s, 2H), 6.43(s, 1H), 6.93(dd, J=8.4, 2.1Hz, 1H), 6.94(d, J=8.7Hz, 2H), 7.09(d, J=2.1Hz, 1H), 7.11(d, J=8.4Hz, 1H), 7.29(ddd, J=7.8, 4.8, 1.5Hz, 1H), 7.49(brd, J=7.8Hz, 1H), 7.53(d, J=8.7Hz, 2H), 7.70(ddd, J=7.8, 7.8, 1.5Hz, 1H), 8.61(brd, J=4.8Hz, 1H) IR(KBr) 3432, 1611, 1588, 1562, 1523, 1488, 1467, 1226, 1114, 1071, 1015, 939, 824, 778, 758cm⁻¹ I-1244 foam ¹H NMR(CDCl₃) δ 3.45(s, 3H), 3.75(s, 3H), 5.01(s, 2H), 6.45(s, 1H), 6.92(d, J=8.7Hz, 2H), 6.99(dd, J=8.4, 2.1Hz, 1H), 7.10(d, J=2.1Hz, 1H), 7.14(d, J=8.4Hz, 1H), 7.30–7.36(m, 3H), 7.46–7.49(m, 2H), 7.54(d, J=8.7Hz, 2H) IR(KBr) 3433, 1612, 1589, 1523, 1489, 1403, 1224, 1192, 1113, 1070, 1013, 938, 813, 758cm⁻¹ I-1245 foam ¹H NMR(CDCl₃) δ 3.45(s, 3H), 3.75(s, 3H), 5.01(s, 2H), 6.45(s, 1H), 6.92(d, J=8.7Hz, 2H), 6.99(dd, J=5.1, 3.6Hz, 1H), 6.99(dd, J=8.4, 2.1Hz, 1H), 7.10(d, J=2.1Hz, 1H), 7.11(d, J=8.4Hz, 1H), 7.27(dd, J=3.6, 1.0Hz, 1H), 7.29(dd, J=5.1, 1.0Hz, 1H), 7.54(d, J=8.7Hz, 2H) IR(KBr) 3433, 1612, 1589, 1523, 1488, 1403, 1241, 1224, 1192, 1113, 1070, 1011, 826cm⁻¹

TABLE 247 I-1246 foam ¹H NMR(CDCl₃) δ 3.45(s, 3H), 3.75(s, 3H), 4.93(s, 2H), 5.70(d, J=1.5Hz, 1H), 5.75(d, J=1.5Hz, 1H), 6.45(s, 1H), 6.92(d, J=8.7Hz, 2H), 6.99(dd, J=8.4, 2.1Hz, 1H), 7.05(d, J=8.4Hz, 1H), 7.10(d, J=2.1Hz, 1H), 7.54(d, J=8.7Hz, 2H) IR(KBr) 3432, 1611, 1590, 1523, 1489, 1403, 1224, 1193, 1113, 1071, 1010, 938, 826cm⁻¹ I-1247 foam ¹H NMR(CDCl₃) δ 3.45(s, 3H), 3.75(s, 3H), 5.53(d, J=10.5Hz, 1H), 5.69(d, J=16.5Hz, 1H), 6.11(ddd, J=16.5, 10.5, 6.3Hz, 1H), 6.44(d, J=6.3Hz, 1H), 6.45(s, 1H), 6.88(d, J=8.4Hz, 1H), 6.91–6.93(m, 2H), 6.92(d, J=8.7Hz, 2H), 7.53(d, J=8.7Hz, 2H) IR(KBr) 3433, 1611, 1592, 1522, 1485, 1403, 1226, 1106, 1059, 814cm⁻¹ I-1248 foam ¹H NMR(CDCl₃) δ 1.16(t, J=7.5Hz, 3H), 2.26(tq, J=2.1, 7.5Hz, 2H), 3.45(s, 3H), 3.75(s, 3H), 4.76(t, J=2.1Hz, 2H), 6.45(s, 1H), 6.91(d, J=8.7Hz, 2H), 6.96(dd, J=2.1, 8.4Hz, 1H), 7.06(d, J=8.4Hz, 1H), 7.07(d, J=2.1Hz, 1H), 7.53(d, J=8.7Hz, 2H) IR(KBr) 3434, 2230, 1612, 1590, 1523, 1479, 1225, 1113, 1070, 1005, 938, 815cm⁻¹ I-1249 foam ¹H NMR(CDCl₃) δ 3.38(s, 3H), 3.67(s, 3H), 5.12(s, 2H), 6.43(s, 1H), 6.56(d, J=3.3Hz, 1H), 6.79(dd, J=2.1, 8.1Hz, 1H), 6.84(d, J=8.7Hz, 2H), 6.87(d, J=2.1Hz, 1H), 7.02(d, J=3.3Hz, 1H), 7.02(d, J=8.1Hz, 1H), 7.45(d, J=8.7Hz, 2H) IR(KBr) 3431, 1698, 1611, 1523, 1489, 1405, 1246, 1114, 1071, 1012, 816, 786cm⁻¹ I-1250 ¹H NMR(CDCl₃) δ 3.38(s, 3H), 3.67(s, 3H), 4.66(tt, J=2.7, 6.9Hz, 2H), 4.90(tt, J=2.7, 6.9Hz, 2H), 5.43(tt, J=6.9, 6.9Hz, 1H), 6.45(s, 1H), 6.92(d, J=8.7Hz, 2H), 6.96(br.s, 2H), 7.07(s, 1H), 7.53(d, J=8.7Hz, 2H) IR(KBr) 3430, 1955, 1612, 1589, 1522, 1489, 1404, 1248, 1113, 1070, 1008, 938, 845, 825cm⁻¹

TABLE 248 I-1251 foam ¹H NMR(CDCl₃) δ 1.69(dd, J=3.3, 6.9Hz, 3H), 3.46(s, 3H), 3.74(s, 3H), 4.63(dd, J=2.4, 6.3Hz, 2H), 5.28(m, 1H), 5.33(m, 1H), 6.45(s, 1H), 6.92(d, J=8.7Hz, 2H), 6.95(d, J=1.5Hz, 1H), 6.96(br.s, 1H), 7.06(d, J=1.5Hz, 1H), 7.52(d, J=8.7Hz, 2H) IR(KBr) 3436, 2933, 1968, 1612, 1587, 1523, 1489, 1464, 1404, 1112, 1071, 1011, 998, 824cm⁻¹ I-1252 foam ¹H NMR(CDCl₃) δ 1.02(t, J=7.2Hz, 3H), 2.05(ddq, J=3.3, 6.3, 7.2Hz, 2H), 3.46(s, 3H), 3.74(s, 3H), 4.64(dd, J=2.4, 6.0Hz, 2H), 5.40(m, 2H), 6.45(s, 1H), 6.91(d, J=8.7Hz, 2H), 6.94(d, J=2.1, 8.4Hz, 1H), 6.97(d, J=8.4Hz, 1H), 7.06(d, J=2.1Hz, 1H), 7.54(d, J=8.7Hz, 2H) IR(KBr) 3479, 2960, 2933, 1964, 1612, 1582, 1522, 1489, 1403, 1242, 1113, 1072, 1011, 999, 944, 872cm⁻¹ I-1253 foam ¹H NMR(CDCl₃) δ 1.03(d, J=6.6Hz, 6H), 2.34(m, 1H), 3.46(s, 3H), 3.74(s, 3H), 4.63(dd, J=2.7, 6.3Hz, 2H), 5.33(m, 1H), 5.44(m, 1H), 6.45(s, 1H), 6.92(d, J=8.7Hz, 2H), 6.93(d, J=1.8, 7.8Hz, 1H), 6.97(d, J=7.8Hz, 1H), 7.06(d, J=1.8Hz, 1H), 7.53(d, J=8.7Hz, 2H) IR(KBr) 3434, 2958, 1960, 1612, 1589, 1523, 1489, 1226, 1113, 1071, 1011, 939, 825cm⁻¹ I-124 foam ¹ H NMR(CDCl₃) δ 2.62(d, J=2.4Hz, 1H), 3.45(s, 3H), 3.75(s, 3H), 4.18(dd, J=7.2, 11.4Hz, 1H), 4.38(dd, J=2.4, 11.4Hz, 1H), 4.94(ddd, J=2.4, 2.4, 7.2Hz, 1H), 6.44(s, 1H), 6.92(d, J=8.7Hz, 2H), 6.98(d, J=8.4Hz, 1H), 7.01(d, J=1.8, 8.4Hz, 1H), 7.08(d, J=1.8Hz, 1H), 7.52(d, J=8.7Hz, 2H) IR(KBr) 3434, 3283, 2127, 1612, 1586, 15323, 1487, 1226, 1115, 1069, 1007, 943, 825cm⁻¹

TABLE 249 I-1255 mp 148–150° C. ¹H NMR(CDCl₃) δ 2.99(s, 6H), 3.75–3.80(br, 2H), 3.75(s, 3H), 3.77(s, 3H), 6.45–6.53(m, 2H), 6.79–6.83(m, 2H), 6.88(s, 1H), 6.95(s, 1H), 7.17–7.23(m, 1H), 7.48–7.51(m, 2H) IR(KBr) 3600–2800(br), 1630, 1609, 1530, 1492, 1461, 1444, 1388, 1331, 1209, 1165, 1125, 1050, 1028cm⁻¹ I-1256 mp 209–212° C. ¹H NMR(CDCl₃) δ 3.00(s, 6H), 3.11(s, 3H), 3.76(s, 3H), 3.79(s, 3H), 6.66(br s, 1H), 6.78–6.83(m, 2H), 6.87(s, 1H), 6.98(s, 1H), 7.02(dd, J=2.4, 8.4Hz, 1H), 7.10(dd, J=2.4, 10.8Hz, 1H), 7.39–7.52(m, 3H) IR(KBr) 3600–2800(br), 1627, 1609, 1530, 1494, 1463, 1390, 1325, 1213, 1154, 1127, 1052, 1028, 984cm⁻¹ I-1257 mp 198–200° C. ¹H NMR(CDCl₃) δ 1.43(t, J=7.5Hz, 3H), 3.00(s, 3H), 3.19–3.26(m, 2H), 3.76(s, 3H), 3.79(s, 3H), 6.69(br s, 1H), 6.79–6.85(m, 2H), 6.86(s, 1H), 6.97(s, 1H), 7.01(dd, J=2.4, 8.4Hz, 1H), 7.09(dd, J=2.4, 10.8Hz, 1H), 7.37–7.53(m, 3H) IR(KBr) 3600–2800(br), 1611, 1530, 1492, 1495, 1445, 1389, 1355, 1325, 1207, 1163, 1141, 1122, 1051, 1025, 981cm⁻¹ I-1258 IR(KBr) 1612, 1526, 1490, 1444, 1349, 1301, 1196, 1129, 1038cm⁻¹ mp 102–103° C. ¹H NMR(CDCl₃) δ 2.27(s, 3H), 2.31(s, 3H), 3.00(s, 6H), 4.78(d, J=6.6Hz, 2H), 6.24(t, J=6.6Hz, 1H), 6.80(d, J=8.4Hz, 2H), 6.96–7.16(m, 5H), 7.26(d, J=8.4Hz, 2H) I-1259 mp 114–115° C. ¹H NMR(CDCl₃) δ 1.75(s, 3H), 1.79(s, 3H), 3.61(s, 3H), 3.65(s, 3H), 3.74(s, 3H), 3.87(s, 3H), 3.88(s, 3H), 4.63(d, J=6.9Hz, 2H), 5.54–5.62(m, 1H), 6.68(s, 1H), 6.94–7.03(m, 5H), 7.54(d, J=9.0Hz, 2H) IR(KBr) 3433, 2932, 1682, 1605, 1580, 1519, 1465, 1439, 1389, 1290, 1253, 1237, 1186, 1140, 1109, 1089, 1039, 1029, 992, 833cm⁻¹

TABLE 250 I-1260 mp 163–165° C. ¹H NMR(CDCl₃) δ 1.76(s, 3H), 1.81(s, 3H), 3.19(s, 3H), 3.72(s, 3H), 4.20–4.26(m, 4H), 4.62(d, J=6.6Hz, 2H), 5.55(m, 1H), 6.53(s, 1H), 7.00–7.20(m, 3H), 7.49(ABq, J=8.1Hz, 4H) IR(KBr) 3433, 2933, 1523, 1483, 1463, 1433, 1371, 1359, 1340, 1299, 1266, 1227, 1220, 1172, 1149, 1127, 1098cm⁻¹ I-1261 mp 135–137° C. ¹H NMR(CDCl₃) δ −0.03–0.03(m, 2H), 0.36–0.42(m, 2H), 1.00(m, 1H), 1.75(s, 3H), 1.79(s, 3H), 2.56(s, 3H), 3.20(s, 3H), 3.48(d, J=4.8Hz, 2H), 3.78(s, 3H), 3.88(s, 3H), 4.63(d, J=6.9Hz, 2H), 5.54(m, 1H), 6.86(s, 1H), 6.95–6.97(m, 3H), 7.55 (ABq, J=8.7Hz, 4H) IR(KBr) 3433, 2936, 1604, 1519, 1481, 1467, 1369, 1336, 1245, 1231, 1201, 1177, 1153, 1081cm⁻¹ I-1262 mp 181–182° C. ¹H NMR(CDCl₃) δ 1.76(s, 3H), 1.80(s, 3H), 3.72(s, 3H), 4.19–4.26(m, 4H), 4.62(d, J=6.9Hz, 2H), 4.91(bs, 1H), 5.55 (m, 1H), 6.53(s, 1H), 6.89–7.49(m, 7H) IR(KBr) 3404, 1612, 1523, 1485, 1462, 1434, 1373, 1266, 1227, 1212, 1116, 1101cm⁻¹ I-1263 mp 80–82° C. ¹H NMR(CDCl₃) δ −0.05–0.09(m, 2H), 0.44–0.51(m, 2H), 1.04(m, 1H), 1.74(s, 3H), 1.78(s, 3H), 3.33(d, J=4.8Hz, 2H), 3.75(s, 3H), 3.88(s, 3H), 4.63(d, J=6.6Hz, 2H), 4.98(s, 1H), 5.57(m, 1H), 6.15(s, 1H), 6.46(s, 1H), 6.89–7.03(m, 5H), 7.52–7.56(m, 2H) IR(KBr) 3374, 1614, 1523, 1490, 1465, 1446, 1391, 1267, 1235, 1172, 1113, 1073cm⁻¹ I-1264 mp 112–113° C. ¹H NMR(CDCl₃) δ 2.19(s, 3H), 2.28(s, 3H), 3.91(s, 3H), 5.20(s, 2H), 6.84–6.86(m, 1H), 6.92–6.97(m, 2H), 7.09(s, 1H), 7.16(s, 1H), 7.31–7.43(m, 5H), 7.47–7.49(m, 2H), 7.60(d, J=10.2Hz, 1H), 8.01(brs, 1H) IR(KBr) 3421, 3303, 2935, 1711, 1519, 1490, 1365, 1231, 1198, 1178, 1134, 1009, 864cm⁻¹

TABLE 251 I-1265 mp 85–86° C. ¹H NMR(CDCl₃) δ 2.85(s, 3H), 3.32(s, 3H), 3.82(s, 3H), 3.96(s, 3H), 5.38(s, 2H), 7.04(s, 1H), 7.22(s, 1H), 7.25(d, J=8.4Hz, 1H), 7.35(d, J=8.4Hz, 1H), 7.48–7.67(m, 7H), 8.45(brs, 1H) IR(KBr) 3432, 2938, 1740, 1608, 1517, 1483, 1396, 1366, 1271, 1179, 1111, 1080, 832, 810, 698cm⁻¹ I-1266 mp 79–80° C. ¹H NMR(CDCl₃) δ 2.14(s, 3H), 3.50(s, 3H), 4.95(brs, 1H), 5.22(s, 2H), 5.88(brs, 1H), 6.81(s, 1H), 6.94(d, J=8.1Hz, 2H), 7.02–7.14(m, 3H), 7.37–7.56(m, 7H) IR(KBr) 3409, 2933, 1612, 1522, 1488, 1454, 1400, 1266, 1229, 1199, 1162, 1007, 834, 696cm⁻¹ I-1267 mp 87–88° C. ¹H NMR(CDCl₃) δ 2.13(s, 3H), 2.59(s, 3H), 3.20(s, 3H), 3.55(s, 3H), 5.22(s, 2H), 6.99–7.17(m, 5H), 7.34–7.48(m, 6H), 7.67(d, J=8.4Hz, 2H) IR(KBr) 3428, 2931, 1612, 1522, 1488, 1454, 1400, 1266, 1230, 1163, 1007, 835cm⁻¹ I-1268 mp 76–77° C. ¹H NMR(CDCl₃) δ 1.72(s, 3H), 1.77(s, 6H), 1.81(s, 3H), 2.69(s, 3H), 3.24(s, 3H), 3.61(s, 3H), 3.79(s, 3H), 4.12–4.20(m, 1H), 4.55–4.61(m, 1H), 4.64(d, J=6.6Hz, 2H), 5.25(t, J=7.5Hz, 1H), 5.50(t, J=6.4Hz, 1H), 6.85(s, 1H), 7.05–7.11(m, 2H), 7.34–7.40(m, 3H) IR(KBr) 3423, 2939, 1707, 1521, 1484, 1367, 1241, 1178, 1079, 1034, 972, 799, 521cm⁻¹ I-1269 mp 73–74° C. ¹H NMR(CDCl₃) δ 2.17(s, 3H), 2.28(s, 3H), 5.16(s, 2H), 5.71(brs, 1H), 6.83(d, J=8.1Hz, 1H), 6.97–7.00(m, 2H), 7.08 (s, 1H), 7.15(s, 1H), 7.32–7.33(m, 2H), 7.36–7.45(m, 5H), 7.60(d, J=10.5Hz, 1H), 8.05(brs, 1H) IR(KBr) 3410, 2923, 1718, 1606, 1540, 1521, 1489, 1424, 1282, 1179, 976, 728cm⁻¹

TABLE 252 I-1270 mp 65–67° C. ¹H NMR(CDCl₃) δ 1.77(s, 3H), 1.81(s, 3H), 2.14(s, 3H), 2.72(s, 3H), 3.20(s, 3H), 3.56(s, 3H), 4.64(d, J=6.9Hz, 2H), 5.53(t, J=6.6Hz, 1H), 7.01–7.11(m, 3H), 7.18(s, 1H), 7.37(d, J=8.7Hz, 2H), 7.67(d, J=8.7Hz, 2H), IR(KBr) 3434, 2938, 1519, 1478, 1365, 1267, 1176, 1151, 968, 871, 799, 524cm⁻¹ I-1271 mp 99–100° C. ¹H NMR(CDCl₃) δ 1.76(s, 6H), 1.79(s, 3H), 1.81(s, 3H), 3.52(s, 3H), 3.72(s, 3H), 4.61(d, J=7.2Hz, 2H), 5.36(t, J=6.6Hz, 1H), 5.53(t, J=5.7Hz, 1H), 5.69(brs, 1H), 5.81(brs, 1H), 6.43(s, 1H), 6.46–6.52(m, 1H), 6.95(s, 2H), 7.05(s, 1H), 7.10–7.16(m, 1H) IR(KBr) 3496, 3407, 2933, 1638, 1535, 1493, 1098, 1000cm⁻¹ I-1272 mp 75–76° C. ¹H NMR(CDCl₃) δ 2.17(s, 3H), 2.28(s, 3H), 3.12(s, 3H), 5.18(s, 2H), 7.09–7.14(m, 4H), 7.26–7.47(m, 8H), 7.61(d, J=11.4Hz, 1H), 8.00(brs, 1H) IR(KBr) 3330, 2927, 1731, 1607, 1541, 1521, 1488, 1364, 1290, 1169, 1105, 975, 878, 811cm⁻¹ I-1273 mp 112–113° C. ¹H NMR(CDCl₃) δ 1.76(s, 3H), 1.81(s, 3H), 2.11(s, 3H), 3.47(s, 3H), 4.64(d, J=6.6Hz, 2H), 4.83(brs, 1H), 5.56(t, J=7.2Hz, 1H), 5.84(brs, 1H), 6.78(s, 1H), 6.91(d, J=8.7Hz, 2H), 7.02–7.10(m, 3H), 751(d, J=8.4Hz, 2H), IR(KBr) 3498, 2978, 1613, 1522, 1487, 1453, 1302, 1204, 1232, 1196, 987, 812cm⁻¹ I-1274 oil ¹H NMR(CDCl₃) δ 1.73(s, 3H), 1.76(s, 3H), 1.77(s, 3H), 1.79(s, 3H), 2.22(s, 3H), 2.27(s, 3H), 3.73(d, J=6.0Hz, 2H), 3.88(s, 3H), 4.63(d, J=6.6Hz, 2H), 5.36(t, J=6.0Hz, 1H), 5.57(t, J=6.6Hz, 1H), 6.40–6.51(m, 2H), 6.87–6.95(m, 3H), 7.05–7.14(m, 3H) IR(CHCl₃) 3021, 2934, 1628, 1523, 1492, 1235, 1219, 1139cm⁻¹

TABLE 253 I-1275 mp 64–65° C. ¹H NMR(CDCl₃) δ 1.74(s, 3H), 1.77(s, 6H), 1.82(s, 3H), 2.16(s, 3H), 2.29(s, 3H), 3.23(s, 3H), 4.36(d, J=7.5Hz, 2H), 4.64(d, J=6.3Hz, 2H), 5.28(t, J=8.4Hz, 1H), 5.51(t, J=6.3Hz, 1H), 7.01–7.16(m, 6H), 7.24–7.35(m, 2H) IR(KBr) 3422, 2926, 1698, 1519, 1489, 1367, 1209, 1170, 962, 807cm⁻¹ I-1276 oil ¹H NMR(CDCl₃) δ 2.21(s, 3H), 2.26(s, 3H), 3.95(d, J=6.6Hz, 2H), 4.28(brs, 1H), 4.78(d, J=6.0Hz, 2H), 6.05(t, J=6.3Hz, 1H), 6.24(t, J=6.3Hz, 1H), 6.36–6.49(m, 2H), 6.97–7.15(m, 6H) IR(CHCl₃) 3446, 3009, 1628, 1525, 1492, 1274, 1224, 1130, 883cm⁻¹ I-1277 mp 64–65° C. ¹H NMR(CDCl₃) δ 1.76(s, 3H), 1.80(s, 6H), 1.85(s, 3H), 2.23(s, 3H), 2.30(s, 3H), 3.74(d, J=6.3Hz, 2H), 4.64(d, J=6.0Hz, 2H), 5.38(t, J=6.6Hz, 1H), 5.55(t, J=6.9Hz, 1H), 5.73(brs, 1H), 6.41–6.50(m, 2H), 6.84–7.15(m, 6H) IR(KBr) 3354, 2971, 1627, 1522, 1490, 1274, 1200, 1128, 990, 843cm⁻¹ I-1278 mp 153–154° C. ¹H NMR(CDCl₃) δ 1.77(s, 3H), 1.82(s, 3H), 1.95(s, 12H), 4.64(d, J=6.9Hz, 2H), 4.78(s, 1H), 5.57(t, J=6.9Hz, 1H), 6.85(ddd, J=8.3, 2.1, 1.2Hz, 1H), 6.90(d, J=8.6Hz, 2H), 6.92(dd, J=12.0, 2.1Hz, 1H), 7.04(d, J=8.6Hz, 2H), 7.04(t, J=8.3Hz, 1H), IR(KBr) 3433, 1514, 1293, 1262, 1242, 1112, 984cm⁻¹ I-1279 mp 115–117° C. ¹H NMR(CDCl₃) δ 1.76(s, 3H), 1.81(s, 3H), 2.23(s, 3H), 3.21(s, 3H), 3.81(s, 3H), 4.63(d, J=6.6Hz, 2H), 5.55(t, J=6.6Hz, 1H), 6.81(s, 1H), 7.02(t, J=8.6Hz, 1H), 7.20(s, 1H), 7.24–7.28(m, 1H), 7.33–7.44(m, 3H) IR(KBr) 3434, 1522, 1492, 1337, 1218, 1200, 1148, 979, 876cm⁻¹

TABLE 254 I-1280 mp 88–90° C. ¹H NMR(CDCl₃) δ 1.76(s, 3H), 1.80(s, 3H), 2.24(s, 3H), 3.80(s, 3H), 4.63(d, J=6.7Hz, 2H), 4.88(br s, 1H), 5.55(t, J=6.7Hz, 1H), 6.83(s, 1H), 6.90(d, J=8.7Hz, 2H), 7.01(t, J=8.6Hz, 1H), 7.18(s, 1H), 7.24–7.28(m, 3H), 7.36(dd, J=12.9, 2.1Hz, 1H) IR(KBr) 3400, 1523, 1493, 1263, 1217, 1128, 977, 836cm⁻¹ I-1281 mp 158–159° C. ¹H NMR(CDCl₃) δ 1.76(s, 3H), 1.80(d, J=0.3Hz, 3H), 2.10(s, 3H), 2.34(s, 3H), 2.50(s, 3H), 3.87(s, 3H), 4.63(d, J=6.9Hz, 2H), 5.14(s, 1H), 5.55(m, 1H), 5.88(s, 1H), 6.77–6.82(m, 2H), 6.85–6.91(m, 2H), 6.98(d, J=8.1Hz, 1H), 7.13(s, 1H), 7.18–7.24(m, 2H) IR(KBr) 3465, 1610, 1516, 1473, 1382, 1322, 1307, 1266, 1240, 1213, 1179, 1168, 1147, 1100, 982, 836cm⁻¹ I-1282 mp 85–86° C. ¹H NMR(CDCl₃) δ 0.99(d, J=6.2Hz, 6H), 1.71–1.98(m, 3H), 2.27(s, 3H), 2.29(s, 3H), 3.20(s, 3H), 3.88(s, 3H), 4.10(t, J=6.8Hz, 2H), 6.88(dd, J=2.0, 8.6Hz, 1H), 6.88(d, J=2.0Hz, 1H), 6.95(d, J=8.6Hz, 1H), 7.30–7.46(m, 4H) IR(KBr) 1519, 1488, 1375, 1255, 1243, 1214, 1204, 1173, 1154, 1134, 867, 850, 792cm⁻¹ I-1283 mp 117–118° C. ¹H NMR(CDCl₃) δ 0.99(d, J=6.3Hz, 6H), 1.75–1.94(m, 3H), 2.27(s, 3H), 2.28(s, 3H), 3.88(s, 3H), 4.10(t, J=6.6Hz, 2H), 4.91(s, 1H), 6.86–6.91(m, 4H), 6.94(d, J=8.7Hz, 1H), 7.12(s, 1H), 7.15(s, 1H), 7.22–7.27(m, 2H) IR(KBr) 3438, 1611, 1522, 1490, 1475, 1464, 1446, 1256, 1242, 1212, 1180, 1171, 1137, 1032, 834, 818cm⁻¹ I-1284 mp 156–157° C. ¹H NMR(CDCl₃) δ 3.46(s, 3H), 3.76(s, 3H), 3.89(s, 3H), 4.78(d, J=6.3Hz, 2H), 4.99(s, 1H), 5.96(s, 1H), 6.25(t, J=6.3Hz, 1H), 6.47(s, 1H), 6.90–6.95(m, 2H), 6.93(d, J=7.8Hz, 1H), 7.04(dd, J=2.1, 7.8Hz, 1H), 7.04(d, J=2.1Hz, 1H), 7.51–7.57(m, 2H) IR(KBr) 3455, 1612, 1522, 1487, 1456, 1396, 1269, 1234, 1223, 1209, 1173, 1140, 1115, 1024, 885, 825, 813cm⁻¹

TABLE 255 I-1285 mp 84–85° C. ¹H NMR(CDCl₃) δ 1.00(d, J=6.6Hz, 6H), 1.71–1.96(m, 3H), 2.27(s, 6H), 4.11(t, J=6.9Hz, 2H), 4.80(br s, 1H), 6.86–6.92 (m, 2H), 6.97–7.14(m, 5H), 7.22–7.27(m, 2H) IR(KBr) 3389, 1523, 1491, 1476, 1427, 1301, 1276, 1233, 1196, 1168, 1126, 836, 815cm⁻¹ I-1286 mp 152–153° C. ¹H NMR(CDCl₃) δ 1.76(s, 3H), 1.80(d, J=0.6Hz, 3H), 2.12(s, 3H), 2.20(s, 3H), 3.39(s, 3H), 3.87(s, 3H), 4.64(d, J=6.3Hz, 2H), 4.79(br s, 1H), 5.56–5.61(m, 1H), 6.82–6.97(m, 6H), 7.21–7.26(m, 2H) IR(CHCl₃) 3596, 3440, 3011, 2935, 1676, 1612, 1588, 1518, 1473, 1449, 1259, 1238, 1173cm⁻¹ I-1287 mp 123–125° C. ¹H NMR(CDCl₃) δ −0.01–0.08(m, 2H), 0.44–0.50(m, 2H), 1.01(m, 1H), 3.21(s, 3H), 3.34(d, J=7.5Hz, 2H), 3.75(s, 3H), 3.91(s, 3H), 5.21(s, 2H), 6.08(s, 1H), 6.45(s, 1H), 6.97–7.04(m, 3H), 7.26–7.72(m, 9H) I-1288 mp 177–178° C. ¹H NMR(CDCl₃) δ 0.27(t, J=4.8Hz, 1H), 0.60(dd, J=4.8, 8.7Hz, 1H), 1.13(s, 3H), 1.17(s, 3H), 1.13–1.22(m, 1H), 3.46 (s, 3H), 3.75(s, 3H), 3.80(s, 3H), 4.00(dd, J=7.8, 10.5Hz, 1H), 4.12(dd, J=6.6, 10.5Hz, 1H), 4.95(bs, 1H), 5.91(s, 1H), 6.46(s, 1H), 6.91–7.02(m, 5H), 7.52–7.56(m, 2H) IR(KBr) 3479, 3434, 3389, 2940, 1614, 1589, 1523, 1490, 1466, 1395, 1361, 1319, 1271, 1238, 1218, 1174, 1137, 1117, 1072, 1011cm⁻¹ I-1289 mp 153–155° C. ¹H NMR(CDCl₃) δ 1.76(s, 3H), 1.80(s, 3H), 2.25(s, 3H), 3.80(s, 3H), 3.89(s, 3H), 4.63–4.65(d, J=6.6Hz, 2H), 4.80(br, 1H), 5.57(m, 1H), 6.86–6.97(m, 6H), 7.18(s, 1H), 7.45–7.48(m, 2H) IR(CHCl₃) 3596, 1609, 1523, 1493, 1464, 1387, 1256, 1173, 1138, 1042, 1032, 997, 834cm⁻¹

TABLE 256 I-1290 mp 150–152° C. ¹H NMR(CDCl₃) δ 2.25(s, 3H), 3.80(s, 3H), 3.90(s, 3H), 4.74–4.80(m, 3H), 6.26(t, J=6.0Hz, 1H), 6.85–6.92(m, 6H), 7.19(s, 1H), 7.45–7.48(m, 2H) IR(CHCl₃) 3596, 2958, 2938, 1609, 1523, 1493, 1464, 1389, 1328, 1257, 1173, 1140, 1102, 1030, 886, 854, 834cm⁻¹ I-1291 mp 117–118° C. ¹H NMR(CDCl₃) δ 1.76(s, 3H), 1.79(s, 3H), 2.28(s, 3H), 2.31(s, 3H), 3.01(s, 6H), 3.88(s, 3H), 4.63(d, J=6.6Hz, 2H), 5.53–5.60(m, 1H), 6.76–6.96(m, 5H), 7.15(s, 2H), 7.28(d, J=8.7Hz, 2H) IR(KBr) 1611, 1529, 1490, 1447, 1359, 1322, 1239, 1214, 1193, 1135, 1038,cm⁻¹ I-1292 mp 116–118° C. ¹H NMR(CDCl₃) 2.24(s, 3H), 3.81(s, 3H), 4.77(d, J=6.3Hz, 2H), 4.90(br s, 1H), 6.23(t, J=6.3Hz, 1H), 6.83(s, 1H), 6.90 (d, J=8.7Hz, 2H), 6.99(t, J=8.6Hz, 1H), 7.17(s, 1H), 7.25(d, J=8.7Hz, 2H), 7.27(ddd, J=8.6, 2.1, 1.2Hz, 1H), 7.37 (dd, J=12.6, 2.1Hz, 1H) IR(KBr) 3596, 1731, 1613, 1523, 1493, 1259, 1130, 1033, 885cm⁻¹ I-1293 mp 151–154° C. ¹H NMR(CDCl₃) δ 2.23(s, 3H), 3.21(s, 3H), 3.80(s, 3H), 3.93(s, 3H), 5.20(s, 2H), 6.81(s, 1H), 6.95(d, J=8.4Hz, 1H), 7.05(dd, J=8.4, 2.1Hz, 1H), 7.15(d, J=2.1Hz, 1H), 7.21(s, 1H), 7.30–7.50(m, 9H) IR(KBr) 1490, 1361, 1243, 1148, 1032, 876cm⁻¹ I-1294 mp 119–121° C. ¹H NMR(CDCl₃) δ 1.76(s, 3H), 1.79(s, 3H), 2.24(s, 3H), 3.21(s, 3H), 3.80(s, 3H), 3.91(s, 3H), 4.63(d, J=6.5Hz, 2H), 5.56(t, J=6.5Hz, 1H), 6.82(s, 1H), 6.94(d, J=8.4Hz, 1H), 7.10(dd, J=8.4, 1.5Hz, 1H), 7.13(d, J=1.5Hz, 1H), 7.23(s, 1H), 7.36(d, J=8.3Hz, 2H), 7.43(d, J=8.3Hz, 2H) IR(KBr) 1519, 1490, 1364, 1156, 1031, 971, 858cm⁻¹

TABLE 257 I-1295 mp 135–137° C. ¹H NMR(CDCl₃) δ 1.75(s, 3H), 1.78(s, 3H), 2.25(s, 3H), 3.80(s, 3H), 3.90(s, 3H), 4.63(d, J=6.7Hz, 2H), 4.95(s, 1H), 5.56(t, J=6.7Hz, 1H), 6.84(s, 1H), 6.90(d, J=8.7Hz, 2H), 6.94(d, J=8.3Hz, 1H), 7.10(dd, J=8.3, 2.1Hz, 1H), 7.13(d, J=2.1Hz, 1H), 7.21(s, 1H), 7.26(d, J=8.7Hz, 2H) IR(KBr) 3423, 1609, 1523, 1493, 1258, 1219, 1142, 1033, 834cm⁻¹ I-1296 mp 140–141° C. ¹H NMR(CDCl₃) δ 1.46(t, J=6.9Hz, 3H), 3.46(s, 3H), 3.75(s, 3H), 4.13(q, J=6.9Hz, 2H), 4.77(d, J=6.0Hz, 2H), 5.05 (s, 1H), 5.95(s, 1H), 6.25(t, J=6.0Hz, 1H), 6.47(s, 1H), 6.90–6.97(m, 3H), 7.01–7.06(m, 2H), 7.50–7.57(m, 2H) IR(KBr) 3463, 3433, 1613, 1521, 1491, 1259, 1400, 1267, 1235, 1204, 1167, 1136, 1112, 1097, 1076, 1019, 993, 882, 824, 811cm⁻¹ I-1297 mp 204–205° C. ¹H NMR(DMSO-d₆) δ 2.21(s, 3H), 2.22(s, 3H), 2.87(s, 3H), 3.02(s, 3H), 4.96(s, 2H), 6.80–6.86(m, 2H), 7.05–7.11(m, 4H), 7.13–7.19(m, 2H), 7.20–7.27(m, 1H) IR(KBr) 3153, 1644, 1590, 1522, 1487, 1437, 1314, 1264, 1231, 1197, 1127, 1067, 833cm⁻¹ I-1298 mp 155–158° C. ¹H NMR(CDCl₃) δ 3.21(s, 3H), 3.45(s, 3H), 3.75(s, 3H), 4.42(s, 4H), 5.93(s, 1H), 6.44(s, 1H), 6.90–6.96(m, 1H), 7.06–7.11 (m, 1H), 7.19–7.39(m, 13H), 7.67–7.72(m, 2H) IR(KBr) 3445, 2940, 1615, 1521, 1483, 1367, 1149, 875, 707, 546, 526cm⁻¹ I-1299 mp 174–175° C. ¹H NMR(CDCl₃) δ 2.15(s, 3H), 3.20(s, 3H), 3.53(s, 3H), 3.78(s, 3H), 4.40(s, 4H), 6.82(s, 1H), 6.91–7.01(m, 2H), 7.11–7.39 (m, 13H), 7.65–7.70(m, 2H) IR(KBr) 3028, 2936, 1618, 1520, 1482, 1365, 1176, 1151, 1079, 871, 798, 698, 527cm⁻¹

TABLE 258 I-1300 mp 218–221° C. ¹H NMR(CDCl₃) δ 2.69(s, 3H), 3.21(s, 3H), 3.55(s, 3H), 3.77(s, 3H), 6.83(s, 1H), 6.86–6.93(m, 1H), 7.02–7.15(m, 2H), 7.35–7.41(m, 2H), 7.66–7.71(m, 2H) IR(KBr) 3435, 3389, 2940, 1635, 1525, 1362, 1175, 1152, 1076, 962, 874, 802, 527cm⁻¹ I-1301 mp 209–211° C. ¹H NMR(CDCl₃) δ 2.91(s, 3H), 3.22(s, 3H), 3.54(s, 3H), 3.78(s, 3H), 6.86(s, 1H), 7.26–7.33(m, 2H), 7.37–7.42(m, 2H), 7.64–7.71(m, 2H), 8.15(s, 1H), 8.34–8.41(m, 1H) IR(KBr) 3336, 2943, 1736, 1539, 1480, 1356, 1174, 1151, 1077, 881, 799, 523, 507cm⁻¹ I-1302 powder ¹H NMR(CDCl₃) δ 1.50(s, 3H), 1.71(s, 3H), 2.78(s, 3H), 3.23(s, 3H), 3.55(s, 3H), 3.78(s, 3H), 4.11–4.20(m, 1H), 4.54–4.63 (m, 1H), 5.20–5.28(m, 1H), 6.87(s, 1H), 7.25–7.31(m, 3H), 7.37–7.42(m, 2H), 7.66–7.72(m, 2H) IR(KBr) 2941, 1702, 1482, 1369, 1203, 1176, 1152, 1080, 964, 873, 797, 525cm⁻¹ I-1303 mp 133–136° C. ¹H NMR(CDCl₃) δ 1.73(s, 3H), 1.77(s, 3H), 3.45(s, 3H), 3.74–3.78(m, 5H), 4.96(s, 1H), 5.34–5.42(m, 1H), 5.94(s, 1H), 6.45(s, 1H), 6.75–6.81(m, 1H), 6.89–6.95(m, 2H), 7.10–7.18(m, 2H), 7.51–7.56(m, 2H) IR(KBr) 3401, 2935, 1626, 1614, 1527, 1490, 1402, 1267, 1223, 1113, 1071, 1005, 829, 589cm⁻¹ I-1304 mp 170–171° C. ¹H NMR(CDCl₃) δ 2.11(s, 3H), 3.47(s, 3H), 4.40(s, 4H), 4.91(s, 1H), 5.81(s, 1H), 6.77(s, 1H), 6.86–7.08(m, 5H), 7.22–7.33 (m, 10H), 7.48–7.53(m, 2H) IR(KBr) 3483, 3029, 1612, 1523, 1489, 1453, 1400, 1265, 1215, 834, 749, 698, 494, 526cm⁻¹

TABLE 259 I-1305 mp 166–168° C. ¹H NMR(CDCl₃) δ 2.15(s, 3H), 2.17(s, 3H), 3.19(s, 3H), 4.21–4.59(m, 4H), 6.84–7.05(m, 3H), 7.14–7.15(m, 1H), 7.20–7.38 (m, 12H), 7.63–7.69(m, 2H) IR(KBr) 3028, 2938, 1519, 1476, 1454, 1363, 1174, 1151, 969, 873, 801, 700, 525cm⁻¹ I-1306 mp 210–212° C. ¹H NMR(CDCl₃) δ 2.11(s, 3H), 2.90(s, 3H), 3.44(s, 3H), 3.52(s, 3H), 6.82–7.02(m, 3H), 7.30(s, 1H), 7.44–7.49(m, 2H), 7.65–7.71(m, 2H) IR(KBr) 3401, 2850, 1632, 1478, 1365, 1177, 1151, 967, 877, 800, 526cm⁻¹ I-1307 mp 171–173° C. ¹H NMR(CDCl₃) δ 2.13(s, 3H), 2.95(s, 3H), 3.22(s, 3H), 3.55(s, 3H), 7.17–7.22(m, 3H), 7.35–7.41(m, 2H), 7.64–7.69(m, 2H), 8.17(s, 1H), 8.37–8.43(m, 1H) IR(KBr) 3431, 3034, 2942, 1741, 1538, 1478, 1364, 1291, 1152, 971, 870, 801, 525cm⁻¹ I-1308 powder ¹H NMR(CDCl₃) δ 1.47(s, 3H), 1.70(s, 3H), 2.11(s, 3H), 2.67–3.15(m, 3H), 3.22(s, 3H), 3.56(s, 3H), 4.13–4.22(m, 1H), 4.54–4.63(m, 1H), 5.21–5.28(m, 1H), 7.09–7.42(m, 6H), 7.63–7.71(m, 2H) IR(CHCl₃) 2940, 1700, 1519, 1478, 1372, 1175, 1151, 968cm⁻¹ I-1309 mp 139–141° C. ¹H NMR(CDCl₃) δ 1.74(s, 3H), 1.78(s, 3H), 2.13(s, 3H), 3.48(s, 3H), 3.77(d, J=6.6Hz, 2H), 4.70–5.20(br s, 1H), 5.35–5.42 (m, 1H), 5.77(s, 1H), 6.77–6.83(m, 2H), 6.88–6.99(m, 4H), 7.48–7.54(m, 2H) IR(KBr) 3525, 3377, 2931, 1625, 1526, 1488, 1222, 1164, 1011, 833cm⁻¹

TABLE 260 I-1310 mp 177–179° C. ¹H NMR(CDCl₃) δ 1.76(s, 3H), 1.81(s, 3H), 3.20(t, J=8.4Hz, 2H), 3.21(t, J=8.4Hz, 2H), 4.521(d, J=7.2Hz, 2H), 4.523(t, J=8.4Hz, 2H), 4.90(brs, 1H), 5.53(t, J=6.8Hz, 1H), 6.71(s, 1H), 6.89(d, J=8.4Hz, 2H), 6.98(d, J=8.7Hz, 2H), 7.41(d, J=8.7Hz, 2H), 7.45(d, J=9.0Hz, 2H) IR(KBr)3389, 2971, 2911, 1611, 1525, 1394, 1238, 1175, 997, 828cm⁻¹ I-1311 mp 175–177° C. ¹H NMR(CDCl₃) δ 3.20(t, J=8.3Hz, 4H), 4.53(t, J=8.4Hz, 4H), 4.70(d, J=6.3Hz, 2H), 4.88(brs, 1H), 6.19(t, J=6.2Hz, 1H), 6.89(d, J=8.7Hz, 2H), 6.96(d, J=9.0Hz, 2H), 7.41(d, J=9.0Hz, 2H), 7.47(d, J=8.7Hz, 2H) IR(KBr)3409, 3269, 2934, 2901, 1524, 1480, 1395, 1235, 1223, 1003, 881, 817cm⁻¹ I-1312 mp 186–187° C. ¹H NMR(CDCl₃) δ 2.06(s, 3H), 2.16(s, 3H), 4.72(s, 1H), 4.80(d, J=6.3Hz, 2H), 4.83(s, 1H), 6.25(t, J=6.3Hz, 1H)6.76 (s, 1H), 6.86–6.92(m, 2H), 7.03–7.13(m, 3H), 7.21–7.26(m, 2H) IR(CHCl₃)3689, 3598, 3551, 3024, 3008, 1732, 1614, 1520, 1487, 1260, 1223cm⁻¹ I-1313 mp 201° C. ¹H NMR(CDCl₃) δ 2.08(s, 3H), 2.17(s, 3H), 3.88(s, 3H), 4.80(d, J=6.3Hz, 2H), 4.90(br s, 1H), 4.99(s, 1H), 6.26(t, J=6.3Hz, 1H), 6.77(s, 1H), 6.85–6.92(m, 4H), 7.01(d, J=6.9Hz, 1H), 7.22–7.27(m, 2H) IR(CHCl₃)3688, 3598, 3538, 3024, 3014, 2938, 1731, 1631, 1520, 1488, 1240, 1172cm⁻¹ I-1314 mp 132–134° C. ¹H NMR(CDCl₃) δ 2.12(s, 3H), 2.29(s, 3H), 3.00(s, 6H), 3.74(br, 2H), 6.62(dd, J=2.4, 8.1Hz, 1H), 6.77–6.82(m, 3H), 7.01–7.05(m, 2H), 7.12(s, 1H), 7.26–7.31(m, 2H) IR(KBr)3600–2800(br), 1610, 1523, 1483, 1443, 1325, 1297cm⁻¹

TABLE 261 I-1315 mp 123–125° C. ¹H NMR(CDCl₃) δ 2.13(s, 3H), 2.29(m, 4H), 3.00(s, 6H), 3.98(br, 3H), 6.63(dd, J=2.4, 8.1Hz, 1H), 6.77–6.81(m, 3H), 7.02(s, 1H), 7.09–7.13(m, 2H), 7.25–7.32(m, 2H) IR(KBr)3600–2800(br), 1609, 1525, 1488, 1443, 1356, 1232, 1194cm⁻¹ I-1316 mp 125–127° C. ¹H NMR(CDCl₃) δ 2.10(s, 3H), 2.31(s, 3H), 3.01(s, 6H), 6.77–6.84(m, 2H), 7.00(s, 1H), 7.15(s, 1H), 7.27–7.33(m, 3H), 7.52(dd, J=3.0, 12.9Hz, 1H), 7.09(d, J=3.0Hz, 1H), 7.95(br s, 1H) IR(KBr)3600–2800(br), 1707, 1611, 1528, 1484, 1350, 1279, 1229, 1196, 1154cm⁻¹ I-1317 mp 94–95° C. ¹H NMR(CDCl₃) δ 1.77(s, 3H), 1.81(s, 3H), 2.26(s, 6H), 4.63(d, J=6.6Hz, 2H), 5.51–5.60(m, 1H), 6.01(s, 2H), 6.78–6.89 (m, 3H), 6.97–7.15(m, 5H) I-1318 ¹H NMR(CDCl₃) δ 1.77(s, 3H), 1.82(s, 3H), 2.29(s, 6H), 4.64(d, J=6.3Hz, 2H), 5.53–5.60(m, 1H), 6.99–7.21(m, 5H), 7.33–7.39(m, 2H), 7.49(d.d, J=5.4 & 0.3Hz, 1H), 7.80(s, 1H), 7.92(d, J=8.1Hz, 1H) I-1319 mp 188–189° C. ¹H NMR(CDCl₃) δ 1.31(t, J=7.5Hz, 3H), 2.26(s, 3H), 2.29(s, 3H), 2.68(q, J=7.5Hz, 2H), 5.17(s, 2H), 5.70(brs, 1H), 6.83(d, J=6.8Hz, 1H), 6.98–7.00(m, 2H), 7.13(d, J=9.0Hz, 2H), 7.26–7.30(m, 2H), 7.38–7.48(m, 5H), 7.78(brs, 1H), 7.86 (d, J=8.7Hz, 1H) IR(KBr)3444, 3269, 1710, 1533, 1487, 1269, 1244, 1199, 1174, 744, 697cm⁻¹ I-1320 mp 157–159° C. ¹H NMR(CDCl₃) δ 1.30(t, J=7.6Hz, 3H), 2.27(s, 3H), 2.28(s, 3H), 2.68(q, J=7.2Hz, 2H), 3.91(s, 3H), 5.21(s, 2H), 6.81–6.97(m, 3H), 7.14(d, J=7.6Hz, 2H), 7.25–7.51(m, 7H), 7.79(brs, 1H), 7.86(d, J=8.8Hz, 1H) IR(KBr)3434, 3260, 1707, 1519, 1501, 1488, 1260, 1241, 1213, 1172, 744, 697cm⁻¹

TABLE 262 I-1321 mp 186–187° C. ¹H NMR(CDCl₃) δ 1.30(t, J=8.4Hz, 3H), 2.26(s, 3H), 2.27(s, 3H), 2.68(q, J=7.5Hz, 2H), 5.20(s, 2H), 7.04–7.14(m, 6H), 7.26–7.50(m, 6H), 7.79(brs, 1H), 7.86(d, J=8.7Hz, 1H) IR(KBr)3436, 3266, 1709, 1536, 1521, 1487, 1267, 1199, 1176, 744, 697cm⁻¹ I-1322 mp 136–137° C. ¹H NMR(CDCl₃) δ 1.32(t, J=7.5Hz, 3H), 2.28(s, 3H), 2.30(s, 3H), 2.70(q, J=7.5Hz, 2H), 3.13(s, 3H), 5.19(s, 2H), 7.12–7.15(m, 3H), 7.26–7.29(m, 3H), 7.37–7.50(m, 5H), 7.80(brs, 1H), 7.87(d, J=9.0Hz, 1H) IR(KBr)3435, 1725, 1536, 1486, 1363, 1292, 1266, 1179, 1163, 1108, 7970, 895, 811, 525cm⁻¹ I-1323 mp 150–151° C. ¹H NMR(CDCl₃) δ 2.18(s, 3H), 2.27(s, 3H), 5.20(s, 2H), 7.04–7.14(m, 6H), 7.26–7.50(m, 6H), 7.60(d, J=12.0Hz, 1H), 7.94(brs, 1H) IR(KBr)3421, 3302, 1712, 1523, 1490, 1422, 1299, 1274, 1205, 1176, 1132, 743, 697cm⁻¹ I-1324 mp 83–84° C. ¹H NMR(CDCl₃) δ 1.30(t, J=7.6Hz, 3H), 1.77(s, 3H), 1.78(s, 3H), 1.81(s, 6H), 2.31(s, 3H), 2.34(s, 3H), 2.56(q, J=7.6Hz, 2H), 3.80(d, J=6.4Hz, 2H), 3.90(s, 3H), 4.65(d, J=6.2Hz, 2H), 5.44(d, J=6.2Hz, 2H), 5.44(t, J=5.2Hz, 1H), 5.59 (t, J=5.4Hz, 1H), 6.73(d, J=8.0Hz, 1H), 6.92–6.94(m, 3H), 7.12–7.20(m, 4H) IR(KBr)3428, 3374, 2964, 1607, 1519, 1494, 1458, 1311, 1256, 1239, 1139, 1036, 1002, 855, 820cm⁻¹ I-1325 mp 113–114° C. ¹H NMR(CDCl₃) δ 1.30(t, J=7.4Hz, 3H), 1.76(s, 3H), 1.78(s, 3H), 1.80(s, 3H), 1.84(s, 3H), 2.30(s, 3H), 2.32(s, 3H), 2.55(q, J=7.6Hz, 2H), 3.79(d, J=6.6Hz, 2H), 4.63(d, J=6.6Hz, 2H), 5.43(t, J=5.6Hz, 1H), 5.55(t, J=6.6Hz, 1H), 5.73(brs, 1H), 6.72(d, J=8.0Hz, 1H), 6.83–6.98(m, 3H), 7.11–7.19(m, 4H) IR(KBr)3413, 3298, 2965, 2924, 1518, 1494, 1435, 1242, 1127, 1013, 883cm⁻¹

TABLE 263 I-1326 mp 81–82° C. ¹H NMR(CDCl₃) δ 1.29(t, J=7.4Hz, 3H), 1.74(s, 3H), 1.77(s, 3H), 1.78(s, 3H), 1.81(s, 3H), 2.27(s, 3H), 2.31(s, 3H), 2.54(q, J=7.2Hz, 2H), 3.79(d, J=7.2Hz, 2H), 4.63(d, J=6.6Hz, 2H), 5.42(t, J=6.4Hz, 1H), 5.55(t, J=6.6Hz, 1H), 6.71(d, J=8.0Hz, 1H), 7.04–7.19(m, 7H) IR(KBr)3413, 2969, 2912, 2856, 1613, 1520, 1492, 1295, 1261, 1127, 1004, 881, 813cm⁻¹ I-1327 mp 94–95° C. ¹H NMR(CDCl₃) δ 1.74(s, 3H), 1.77(s, 6H), 1.81(s, 3H), 2.21(s, 3H), 2.26(s, 3H), 3.72(d, J=6.9Hz, 2H), 4.63(d, J=6.3Hz, 2H), 5.35(t, J=6.9Hz, 1H), 5.55(t, J=6.9Hz, 1H), 6.37–6.48(m, 2H), 7.01–7.13(m, 6H) IR(KBr)3423, 2967, 2918, 1627, 1525, 1488, 1296, 1267, 1129, 981, 837, 805cm⁻¹ I-1328 mp 178–180° C.(decomp.) ¹H NMR(DMSO-d₆) δ 3.30(s, 3H), 3.64(s, 3H), 4.45(s, 2H), 5.65(s, 2H), 6.39(s, 1H), 6.65(dd, J=8.4, 2.1Hz, 1H), 6.74 (d, J=2.1Hz, 1H), 6.84(d, J=8.7Hz, 2H), 6.99(d, J=8.4Hz, 1H), 7.43(d, J=8.7Hz, 2H), 9.26(s, 1H) IR(Nujol)3487, 3382, 1696, 1670, 1591, 1523, 1491, 1458, 1243, 1202, 1114, 1077, 1013, 937, 811cm⁻¹ I-1329 mp 205–210° C.(decomp.) ¹H NMR(DMSO-d₆) δ 3.34(s, 3H), 3.44(s, 3H), 3.67(s, 3H), 4.93(s, 2H), 6.43(s, 1H), 6.76(dd, J=8.4, 2.1Hz, 1H), 6.85 (d, J=2.1Hz, 1H), 6.86(d, J=8.7Hz, 2H), 7.04(d, J=8.4Hz, 1H), 7.46(d, J=8.7Hz, 2H) IR(Nujol)3388, 3333, 3270, 1671, 1614, 1579, 1556, 1523, 1443, 1223, 1172, 1121, 1033, 922, 813cm⁻¹ I-1330 mp 185–187° C. ¹H NMR(CDCl₃) δ 1.79(t, J=2.6Hz, 3H), 2.69(m, 2H), 2.75(s, 3H), 3.21(s, 3H), 3.29(s, 3H), 3.56(s, 3H), 3.77(s, 3H), 4.17(t, J=6.6Hz, 2H), 6.84(s, 1H), 7.08(d, J=9.0Hz, 1H), 7.36(dd, J=9.0, 2.1Hz, 1H), 7.38(d, J=8.7Hz, 2H), 7.40(d, J=2.1Hz, 1H), 7.68(d, J=8.7Hz, 2H) IR(Nujol)1604, 1520, 1480, 1175, 1151, 1081, 1012, 971, 948, 878, 840, 807cm⁻¹

TABLE 264 I-1331 foam ¹H NMR(CDCl₃) δ 1.81(t, J=2.4Hz, 3H), 2.65(m, 2H), 3.45(s, 3H), 3.74(s, 3H), 4.16(t, J=6.6Hz, 2H), 6.45(s, 1H), 6.92(d, J=8.7Hz, 2H), 6.95(m, 2H), 7.07(brs, 1H), 7.07(d, J=8.7Hz, 2H) IR(Nujol)3427, 1612, 1586, 1523, 1489, 1251, 1224, 1113, 1071, 1012cm⁻¹ I-1332 foam ¹H NMR(CDCl₃) δ 3.45(s, 3H), 3.75(s, 3H), 4.16(m, 2H), 4.76(m, 2H), 5.89–6.02(m, 2H), 6.45(s, 1H), 6.92(d, J=8.7Hz, 2H), 6.96(m, 2H), 7.09(brs, 1H), 7.53(d, J=8.7Hz, 2H) IR(Nujol)3433, 1612, 1588, 1523, 1489, 1286, 1248, 1224, 1175, 1113, 1070, 1011cm⁻¹ I-1333 foam ¹H NMR(CDCl₃) δ 3.45(s, 3H), 3.74(s, 3H), 4.11(m, 2H), 4.67(m, 2H), 5.96–6.12(m, 2H), 6.45(s, 1H), 6.92(d, J=8.7Hz, 2H), 6.92(d, J=8.4Hz, 1H), 6.96(dd, J=8.4, 2.1Hz, 1H), 7.08(d, J=2.1Hz, 1H), 7.53(d, J=8.7Hz, 2H) IR(Nujol)3434, 1612, 1588, 1523, 1489, 1285, 1248, 1224, 1174, 1112, 1070, 1011cm⁻¹ I-1334 foam ¹H NMR(CDCl₃) δ 1.95(s, 3H), 3.45(s, 3H), 3.75(s, 3H), 4.11(s, 2H), 4.68(d, J=6.9Hz, 2H), 5.75(d, J=6.9Hz, 1H), 6.45(s, 1H), 6.91(d, J=8.7Hz, 2H), 6.96(s, 2H), 7.08(s, 1H), 7.53(d, J=8.7Hz, 2H) IR(KBr)3390, 1612, 1585, 1523, 1491, 1225, 1072, 1003, 822cm⁻¹ I-1335 m.p 179–180° C. ¹H NMR(CDCl₃) δ 1.88(s, 3H), 3.45(s, 3H), 3.75(s, 3H), 4.07(s, 2H), 4.69(d, J=6.6Hz, 2H), 5.89(d, J=6.6Hz, 1H), 6.45(s, 1H), 6.91(d, J=8.7Hz, 2H), 6.92(d, J=8.4Hz, 1H), 6.96(dd, J=1.8, 8.4Hz, 1H), 7.07(d, J=1.8Hz, 1H), 7.53(d, J=8.7Hz, 2H) IR(KBr)3392, 1609, 1584, 1523, 1492, 1226, 1116, 1072, 1002, 813, 782cm⁻¹

TABLE 265 I-136 foam ¹H NMR(CD3OD) δ 3.38(s, 3H), 3.67(s, 3H), 3.88(dd, J=7.8, 9.9Hz, 1H), 4.10(dd, J=3.6, 9.9Hz, 1H), 4.51(m, 1H), 5.25(dt, J=10.5, 1.5Hz, 1H), 5.44(dt, J=17.4, 1.5Hz, 1H), 6.00(ddd, J=5.4, 10.5, 17.4Hz, 1H), 6.43(s, 1H), 6.79(dd, J=1.8, 8.4Hz, 1H), 6.85(d, J=8.7Hz, 2H), 6.86(d, J=1.8Hz, 1H), 6.92(d, J=8.4Hz, 1H), 7.45(d, J=8.7Hz, 2H) IR(KBr)3399, 2934, 1612, 1588, 1523, 1489, 1254, 1114, 1071, 1012, 939, 816cm⁻¹ I-1337 foam ¹H NMR(CDCl₃) δ 3.45(s, 3H), 3.75(s, 3H), 4.20(t, J=2.1Hz, 2H), 4.84(t, J=2.1Hz, 2H), 6.45(s, 1H), 6.92(d, J=8.7Hz, 2H), 6.98(dd, J=2.1, 8.4Hz, 1H), 7.04(d, J=8.4Hz, 1H), 7.09(d, J=2.1Hz, 1H), 7.45(d, J=8.7Hz, 2H) IR(KBr)3431, 1612, 1589, 1523, 1489, 1404, 1224, 1113, 1070, 1011, 939, 826cm⁻¹ I-1338 foam ¹H NMR(CD3OD) δ 3.38(s, 3H), 3.67(s, 3H), 4.25(d, J=21.0Hz, 2H), 4.84(d, J=7.5Hz, 2H), 5.58(dt, J=19.5, 7.5Hz, 1H), 6.43(s, 1H), 6.79(dd, J=2.1, 8.4Hz, 1H), 6.84(d, J=8.7Hz, 2H), 6.86(d, J=2.1Hz, 1H), 6.96(d, J=8.4Hz, 1H), 7.45(d, J=8.7Hz, 2H) IR(KBr)3409, 1701, 1612, 1591, 1523, 1489, 1404, 1246, 1113, 1071, 1010, 939, 816cm⁻¹ I-1339 foam ¹H NMR(CDCl₃) δ 3.44(s, 3H), 3.74(s, 3H), 4.21(d, J=21.3Hz, 2H), 4.66(dd, J=1.8, 7.5Hz, 2H), 5.70(dt, J=16.5, 7.5Hz, 1H), 6.45(s, 1H), 6.95(d, J=8.7Hz, 2H), 6.96(d, J=8.4Hz, 1H), 6.98(dd, J=1.5, 8.4Hz, 1H), 7.09(d, J=1.5Hz, 1H), 7.51(d, J=8.7Hz, 2H) IR(KBr)3411, 1698, 1611, 1588, 1522, 1488, 1223, 1112, 1070, 1011, 939, 825cm⁻¹ I-1340 mp 171–172° C. ¹H NMR(CDCl₃) δ 1.50(s, 3H), 1.67(s, 3H), 1.96(s, 3H), 3.45(s, 3H), 3.77(s, 3H), 4.13–4.49(m, 2H), 5.23–5.30(m, 1H), 5.59(s, 1H), 6.13(s, 1H), 6.47(s, 1H), 6.92–6.98(m, 2H), 7.18–7.35(m, 3H), 7.50–7.57(m, 2H) IR(KBr)3390, 3140, 2935, 1640, 1523, 1401, 1240, 1119, 1070, 835, 820cm⁻¹

TABLE 266 I-1341 mp 216–218° C. ¹H NMR(CDCl₃+CD3OD) δ 1.46(s, 3H), 1.67(s, 3H), 1.95(s, 3H), 2.10(s, 3H), 3.46(s, 3H), 4.16–4.47(m, 2H), 5.21–5.28 (m, 1H), 6.79(s, 1H), 6.88–6.95(m, 2H), 7.11–7.27(m, 3H), 7.45–7.52(m, 2H) IR(KBr)3337, 3099, 2928, 1637, 1608, 1587, 1521, 1444, 1409, 1261, 1232, 1161, 836, 769, 592, 540cm⁻¹ I-1342 mp 103–105° C. ¹H NMR(CDCl₃) δ 1.15(d, J=6.8Hz, 6H), 2.26(s, 3H), 3.08(sept, J=6.8Hz, 1H), 4.94(s, 1H), 5.20(s, 2H), 6.88(d, J=8.7Hz, 2H), 7.04–7.07(m, 3H), 7.12–7.18(m, 1H), 7.18(s, 1H), 7.20(d, J=8.7Hz, 2H), 7.32–7.51(m, 5H) IR(KBr)3429, 1522, 1490, 1262, 1227, 1128, 1011, 833cm⁻¹ I-1343 mp 115–117° C. ¹H NMR(CDCl₃) δ 1.15(d, J=6.6Hz, 6H), 1.77(s, 3H), 1.82(s, 3H), 2.27(s, 3H), 3.08(sept, J=6.8Hz, 1H), 4.64(d, J=6.9Hz, 2H), 4.86(s, 1H), 5.56(t, J=6.9Hz, 1H), 6.89(d, J=8.6Hz, 2H), 7.03(t, J=8.4Hz, 1H), 7.05–7.19(m, 3H), 7.19(s, 1H), 7.21(d, J=8.6Hz, 2H) IR(KBr)3524, 1611, 1523, 1489, 1260, 1228, 1200, 1128, 836cm⁻¹ I-1344 mp 119–120° C. ¹H NMR(CDCl₃) δ 1.15(d, J=6.9Hz, 6H), 2.26(s, 3H), 3.08(sept, J=6.8Hz, 1H), 4.79(d, J=6.3Hz, 2H), 4.85(s, 1H), 6.25(t, J=6.3Hz, 1H), 6.89(d, J=8.7Hz, 2H), 7.01(t, J=8.4Hz, 1H), 7.07–7.12(m, 2H), 7.15(dd, J=12.0, 2.1Hz, 1H), 7.18(s, 1H), 7.20(d, J=8.7Hz, 2H) IR(KBr)3425, 1610, 1523, 1488, 1300, 1263, 1300, 1263, 1227, 1134, 1038, 896cm⁻¹ I-1345 mp 109–110° C. ¹H NMR(CDCl₃) δ 1.34(d, J=6.9Hz, 3H), 2.24(s, 3H), 4.00(q, J=6.9Hz, 2H), 4.77–4.79(m, 3H), 6.24(t, J=6.3Hz, 1H), 6.86–6.90(m, 2H), 6.98–7.19(m, 4H), 7.47–7.50(m, 2H) IR(CHCl₃)3596, 2927, 1612, 1523, 1493, 1476, 1388, 1299, 1259, 1173, 1127, 1049, 885, 834cm⁻¹

TABLE 267 I-1346 mp 114–116° C. ¹H NMR(CDCl₃) δ 1.33(d, J=6.9Hz, 3H), 1.77(s, 3H), 1.81(s, 3H), 2.24(s, 3H), 4.00(q, J=6.9Hz, 2H), 4.63(m, 2H), 4.73(br, 1H), 5.56(m, 1H), 6.81(s, 1H), 6.86–6.90(m, 2H), 7.00–7.19(m, 4H), 7.47–4.51(m, 2H) IR(CHCl₃)3596, 2929, 2877, 1610, 1523, 1493, 1476, 1386, 1329, 1316, 1297, 1261, 1173, 1125, 1048, 992, 834cm⁻¹ I-1347 mp 144–146° C. ¹H NMR(CDCl₃) δ 3.20(s, 3H), 3.40(s, 3H), 3.75(s, 3H), 4.74(s, 2H), 5.19(s, 2H), 6.44(s, 1H), 7.05–7.62(m, 12H) IR(KBr)3437, 1614, 1579, 1520, 1488, 1465, 1453, 1436, 1414, 1393, 1364, 1346, 1299, 1270, 1235, 1198, 1175, 1149, 1129, 1114, 1085, 1063cm⁻¹ I-1348 mp 156–159° C. ¹H NMR(CDCl₃) δ 2.48(s, 3H), 3.05(s, 3H), 3.20(s, 3H), 3.78(s, 3H), 4.83(s, 2H), 5.21(s, 2H), 6.84(s, 1H), 7.02–7.67(m, 12H) IR(KBr)3430, 2940, 1607, 1522, 1481, 1452, 1419, 1389, 1365, 1294, 1273, 1230, 1200, 1176, 1151, 1132, 1080, 1011cm⁻¹ I-1349 mp 155–156° C. ¹H NMR(CDCl₃) δ 1.15(t, J=6.9Hz, 3H), 3.60(q, J=6.9Hz, 2H), 3.75(s, 3H), 3.90(s, 3H), 4.93(bs, 1H), 5.20(s, 2H), 5.98(s, 1H), 6.46(s, 1H), 6.90–7.05(m, 5H), 7.26–7.56(m, 7H) IR(KBr)3409, 2938, 1613, 1522, 1438, 1416, 1396, 1382, 1360, 1268, 1232, 1211, 1169, 1131, 1113, 1078, 1022, 1006cm⁻¹ I-1350 mp 58–60° C. ¹H NMR(DMSO-d₆) δ 1.71(s, 6H), 2.21(s, 3H), 2.22(s, 3H), 3.71–3.75(m, 2H), 5.11(br s, 2H), 5.25–5.29(m, 1H), 5.50–5.53 (m, 1H), 6.60–6.63(m, 2H), 6.66–6.73(m, 1H), 6.95–7.05(m, 6H) IR(KBr)3600–2800(br), 1623, 1527, 1492, 1454, 1428, 1331, 1269, 1257, 1184, 1116cm⁻¹

TABLE 268 I-1351 mp 140–142° C.(dec.) ¹H NMR(CDCl₃) δ 2.33(s, 3H), 4.93(s, 1H), 5.19(s, 2H), 6.89(d, J=8.7Hz, 2H), 7.06(t, J=8.6Hz, 1H), 7.23(d, J=8.7Hz, 2H), 7.24–7.50(m, 10H) IR(KBr)3400, 1609, 1529, 1490, 1269, 1243, 1005, 807, 745cm⁻¹ I-1352 mp 114–116° C. ¹H NMR(CDCl₃) δ 1.77(s, 3H), 1.81(s, 3H), 2.33(s, 3H), 4.63(d, J=6.9Hz, 2H), 4.89(s, 1H), 5.54(t, J=6.9Hz, 1H), 6.89(d, J=8.6Hz, 2H), 7.04(t, J=8.6Hz, 1H), 7.23(d, J=8.6Hz, 2H), 7.25–7.43(m, 5H) IR(KBr)3368, 1609, 1526, 1490, 1271, 1241, 1131, 991, 827, 811cm⁻¹ I-1353 mp 78–79° C. ¹H NMR(CDCl₃) δ 1.77(s, 3H), 1.82(s, 3H), 2.24(s, 3H), 2.27(s, 3H), 4.64(d, J=6.6Hz, 2H), 5.51–5.59(m, 1H), 6.98–7.20 (m, 7H), 7.28–7.36(m, 2H)

TABLE 269 (I)

No. R¹ R² R³ R⁴ R⁵ R⁶ R⁷ R⁸ R⁹ R¹⁰ R¹¹ R¹² R¹³ X Y I-1354 OH H H H H H OMe OMe OH H H H OMs O —CH₂CH═CMe₂ I-1355 OH H H H H H OMe OMe OH H H H OMs O —(CH₂)₂CH═CMe₂ I-1356 OH H H H H H OMe OMe OH H H H OMs O —CH₂CH═CCl₂ I-1357 OH H H H H H OMe OMe OH H H H OMs O —CH₂C≡CMe I-1358 OH H H H H H OMe OMe OH H H H OMs O —CH₂C₆H₄-4-Me I-1359 OH H H H H H OMe OMe OH H H H COOH O —(CH₂)₂CH═CMe₂ I-1360 OH H H H H H OMe OMe OH H H H COOH O —CH₂CH═CCl₂ I-1361 OH H H H H H OMe OMe OH H H H COOH O —CH₂C≡CMe I-1362 OH H H H H H OMe OMe OH H H H COOH O —CH₂C₆H₄-4-Me I-1363 OH H H H H H OMe OMe OH H H H CH₂OH O —(CH₂)₂CH═CMe₂ I-1364 OH H H H H H OMe OMe OH H H H CH₂OH O —CH₂CH═CCl₂ I-1365 OH H H H H H OMe OMe OH H H H CH₂OH O —CH₂C≡CMe I-1366 OH H H H H H OMe OMe OH H H H CH₂OH O —CH₂C₆H₄-4-Me I-1367 OH H H H H H OMe OMe OH H H H F O —(CH₂)₂CH═CMe₂ I-1368 OH H H H H H OMe OMe OH H H H F O —CH₂CH═CCl₂ I-1369 OH H H H H H OMe OMe OH H H H F O —CH₂C≡CMe

TABLE 270 I-1370 OH H H H H H OMe OMe OH H H H F O —CH₂C₆H₄-4-Me I-1371 OH H H H H H OMe OMe COOH H H H OH O —CH₂CH═CCl₂ I-1372 OH H H H H H OMe OMe COOH H H H OH O —CH₂C≡CMe I-1373 OH H H H H H OMe OMe COOH H H H OMs O —CH₂CH═CMe₂ I-1374 OH H H H H H OMe OMe COOH H H H OMs O —(CH₂)₂CH═CMe₂ I-1375 OH H H H H H OMe OMe COOH H H H OMs O —CH₂CH═CCl₂ I-1376 OH H H H H H OMe OMe COOH H H H OMs O —CH₂C≡CMe I-1377 OH H H H H H OMe OMe COOH H H H OMs O —CH₂C₆H₄-4-Me I-1378 OH H H H H H OMe OMe COOH H H H COOH O —CH₂CH═CMe₂ I-1379 OH H H H H H OMe OMe COOH H H H COOH O —(CH₂)₂CH═CMe₂ I-1380 OH H H H H H OMe OMe COOH H H H COOH O —CH₂CH═CCl₂ I-1381 OH H H H H H OMe OMe COOH H H H COOH O —CH₂C≡CMe I-1382 OH H H H H H OMe OMe COOH H H H COOH O —CH₂C₆H₄-4-Me I-1383 OH H H H H H OMe OMe COOH H H H CH₂OH O —CH₂CH═CMe₂ I-1384 OH H H H H H OMe OMe COOH H H H CH₂OH O —(CH₂)₂CH═CMe₂ I-1385 OH H H H H H OMe OMe COOH H H H CH₂OH O —CH₂CH═CCl₂ I-1386 OH H H H H H OMe OMe COOH H H H CH₂OH O —CH₂C≡CMe I-1387 OH H H H H H OMe OMe COOH H H H CH₂OH O —CH₂C₆H₄-4-Me I-1388 OH H H H H H OMe OMe COOH H H H F O —CH₂CH═CCl₂ I-1389 OH H H H H H OMe OMe COOH H H H F O —CH₂C≡CMe I-1390 OH H H H H H OMe OMe CH₂OH H H H OH O —CH₂CH═CMe₂

TABLE 271 I-1391 OH H H H H H OMe OMe CH₂OH H H H OH O —(CH₂)₂CH═CMe₂ I-1392 OH H H H H H OMe OMe CH₂OH H H H OH O —CH₂CH═CCl₂ I-1393 OH H H H H H OMe OMe CH₂OH H H H OH O —CH₂C≡CMe I-1394 OH H H H H H OMe OMe CH₂OH H H H OH O —CH₂C₆H₄-4-Me I-1395 OH H H H H H OMe OMe CH₂OH H H H OMs O —CH₂CH═CMe₂ I-1396 OH H H H H H OMe OMe CH₂OH H H H OMs O —(CH₂)₂CH═CMe₂ I-1397 OH H H H H H OMe OMe CH₂OH H H H OMs O —CH₂CH═CCl₂ I-1398 OH H H H H H OMe OMe CH₂OH H H H OMs O —CH₂C≡CMe I-1399 OH H H H H H OMe OMe CH₂OH H H H OMs O —CH₂C₆H₄-4-Me I-1400 OH H H H H H OMe OMe CH₂OH H H H COOH O —CH₂CH═CMe₂ I-1401 OH H H H H H OMe OMe CH₂OH H H H COOH O —(CH₂)₂CH═CMe₂ I-1402 OH H H H H H OMe OMe CH₂OH H H H COOH O —CH₂CH═CCl₂ I-1403 OH H H H H H OMe OMe CH₂OH H H H COOH O —CH₂C≡CMe I-1404 OH H H H H H OMe OMe CH₂OH H H H COOH O —CH₂C₆H₄-4-Me I-1405 OH H H H H H OMe OMe CH₂OH H H H CH₂OH O —CH₂CH═CMe₂ I-1406 OH H H H H H OMe OMe CH₂OH H H H CH₂OH O —CH₂CH═CCl₂ I-1407 OH H H H H H OMe OMe CH₂OH H H H CH₂OH O —CH₂C≡CMe I-1408 OH H H H H H OMe OMe CH₂OH H H H CH₂OH O —CH₂C₆H₄-4-Me I-1409 OH H H H H H OMe OMe CH₂OH H H H F O —CH₂CH═CMe₂ I-1410 OH H H H H H OMe OMe CH₂OH H H H F O —(CH₂)₂CH═CMe₂ I-1411 OH H H H H H OMe OMe CH₂OH H H H F O —CH₂CH═CCl₂

TABLE 272 I-1412 OH H H H H H OMe OMe CH₂OH H H H F O —CH₂C≡CMe I-1413 OH H H H H H OMe OMe CH₂OH H H H F O —CH₂C₆H₄-4-Me I-1414 OH H H H H H OMe OMe Me H H H OH O —CH₂CH═CCl₂ I-1415 OH H H H H H OMe OMe Me H H H OH O —CH₂C≡CMe I-1416 OH H H H H H OMe OMe Me H H H OMs O —CH₂CH═CMe₂ I-1417 OH H H H H H OMe OMe Me H H H OMs O —(CH₂)₂CH═CMe₂ I-1418 OH H H H H H OMe OMe Me H H H OMs O —CH₂CH═CCl₂ I-1419 OH H H H H H OMe OMe Me H H H OMs O —CH₂C≡CMe I-1420 OH H H H H H OMe OMe Me H H H OMs O —CH₂C₆H₄-4-Me I-1421 OH H H H H H OMe OMe Me H H H COOH O —CH₂CH═CMe₂ I-1422 OH H H H H H OMe OMe Me H H H COOH O —(CH₂)₂CH═CMe₂ I-1423 OH H H H H H OMe OMe Me H H H COOH O —CH₂CH═CCl₂ I-1424 OH H H H H H OMe OMe Me H H H COOH O —CH₂C≡CMe I-1425 OH H H H H H OMe OMe Me H H H COOH O —CH₂C₆H₄-4-Me I-1426 OH H H H H H OMe OMe Me H H H CH₂OH O —CH₂CH═CMe₂ I-1427 OH H H H H H OMe OMe Me H H H CH₂OH O —(CH₂)₂CH═CMe₂ I-1428 OH H H H H H OMe OMe Me H H H CH₂OH O —CH₂CH═CCl₂ I-1429 OH H H H H H OMe OMe Me H H H CH₂OH O —CH₂C≡CMe I-1430 OH H H H H H OMe OMe Me H H H CH₂OH O —CH₂C₆H₄-4-Me I-1431 OH H H H H H OMe OMe Me H H H F O —CH₂CH═CMe₂ I-1432 OH H H H H H OMe OMe Me H H H F O —(CH₂)₂CH═CMe₂

TABLE 273 I-1433 OH H H H H H OMe OMe Me H H H F O —CH₂CH═CCl₂ I-1434 OH H H H H H OMe OMe Me H H H F O —CH₂C≡CMe I-1435 OH H H H H H OMe OMe Me H H H F O —CH₂C₆H₄-4-Me I-1436 OH H H H H H OMe OMe H H H H OH O —CH₂CH═CCl₂ I-1437 OH H H H H H OMe OMe H H H H OH O —CH₂C≡CMe I-1438 OH H H H H H OMe OMe H H H H OH O —CH₂C₆H₄-4-Me I-1439 OH H H H H H OMe OMe H H H H OMs O —(CH₂)₂CH═CMe₂ I-1440 OH H H H H H OMe OMe H H H H OMs O —CH₂CH═CCl₂ I-1441 OH H H H H H OMe OMe H H H H OMs O —CH₂C≡CMe I-1442 OH H H H H H OMe OMe H H H H OMs O —CH₂C₆H₄-4-Me I-1443 OH H H H H H OMe OMe H H H H COOH O —CH₂CH═CMe₂ I-1444 OH H H H H H OMe OMe H H H H COOH O —(CH₂)₂CH═CMe₂ I-1445 OH H H H H H OMe OMe H H H H COOH O —CH₂CH═CCl₂ I-1446 OH H H H H H OMe OMe H H H H COOH O —CH₂C≡CMe I-1447 OH H H H H H OMe OMe H H H H COOH O —CH₂C₆H₄-4-Me I-1448 OH H H H H H OMe OMe H H H H CH₂OH O —CH₂CH═CMe₂ I-1449 OH H H H H H OMe OMe H H H H CH₂OH O —(CH₂)₂CH═CMe₂ I-1450 OH H H H H H OMe OMe H H H H CH₂OH O —CH₂CH═CCl₂ I-1451 OH H H H H H OMe OMe H H H H CH₂OH O —CH₂C≡CMe I-1452 OH H H H H H OMe OMe H H H H CH₂OH O —CH₂C₆H₄-4-Me I-1453 OH H H H H H OMe OMe H H H H F O —(CH₂)₂CH═CMe₂

TABLE 274 I-1454 OH H H H H H OMe OMe H H H H F O —CH₂CH═CCl₂ I-1455 OH H H H H H OMe OMe H H H H F O —CH₂C≡CMe I-1456 OH H H H H H OMe OMe H H H H F O —CH₂C₆H₄-4-Me I-1457 OH H H H H F OMe OMe OH H H H OH O —(CH₂)₂CH═CMe₂ I-1458 OH H H H H F OMe OMe OH H H H OH O —CH₂CH═CCl₂ I-1459 OH H H H H F OMe OMe OH H H H OH O —CH₂C≡CMe I-1460 OH H H H H F OMe OMe OH H H H OH O —CH₂C₆H₄-4-Me I-1461 OH H H H H F OMe OMe OH H H H OMs O —CH₂CH═CMe₂ I-1462 OH H H H H F OMe OMe OH H H H OMs O —(CH₂)₂CH═CMe₂ I-1463 OH H H H H F OMe OMe OH H H H OMs O —CH₂CH═CCl₂ I-1464 OH H H H H F OMe OMe OH H H H OMs O —CH₂C≡CMe I-1465 OH H H H H F OMe OMe OH H H H OMs O —CH₂C₆H₄-4-Me I-1466 OH H H H H F OMe OMe OH H H H COOH O —CH₂CH═CMe₂ I-1467 OH H H H H F OMe OMe OH H H H COOH O —(CH₂)₂CH═CMe₂ I-1468 OH H H H H F OMe OMe OH H H H COOH O —CH₂CH═CCl₂ I-1469 OH H H H H F OMe OMe OH H H H COOH O —CH₂C≡CMe I-1470 OH H H H H F OMe OMe OH H H H COOH O —CH₂C₆H₄-4-Me I-1471 OH H H H H F OMe OMe OH H H H CH₂OH O —CH₂CH═CMe₂ I-1472 OH H H H H F OMe OMe OH H H H CH₂OH O —(CH₂)₂CH═CMe₂ I-1473 OH H H H H F OMe OMe OH H H H CH₂OH O —CH₂CH═CCl₂ I-1474 OH H H H H F OMe OMe OH H H H CH₂OH O —CH₂C≡CMe

TABLE 275 I-1475 OH H H H H F OMe OMe OH H H H CH₂OH O —CH₂C₆H₄-4-Me I-1476 OH H H H H F OMe OMe OH H H H F O —CH₂CH═CMe₂ I-1477 OH H H H H F OMe OMe OH H H H F O —(CH₂)₂CH═CMe₂ I-1478 OH H H H H F OMe OMe OH H H H F O —CH₂CH═CCl₂ I-1479 OH H H H H F OMe OMe OH H H H F O —CH₂C≡CMe I-1480 OH H H H H F OMe OMe OH H H H F O —CH₂C₆H₄-4-Me I-1481 OMs H H H H H OMe OMe OH H H H OH O —CH₂CH═CMe₂ I-1482 OMs H H H H H OMe OMe OH H H H OH O —(CH₂)₂CH═CMe₂ I-1483 OMs H H H H H OMe OMe OH H H H OH O —CH₂CH═CCl₂ I-1484 OMs H H H H H OMe OMe OH H H H OH O —CH₂C≡CMe I-1485 OMs H H H H H OMe OMe OH H H H OH O —CH₂C₆H₄-4-Me I-1486 OMs H H H H H OMe OMe OH H H H OMs O —CH₂CH═CMe₂ I-1487 OMs H H H H H OMe OMe OH H H H OMs O —(CH₂)₂CH═CMe₂ I-1488 OMs H H H H H OMe OMe OH H H H OMs O —CH₂CH═CCl₂ I-1489 OMs H H H H H OMe OMe OH H H H OMs O —CH₂C≡CMe I-1490 OMs H H H H H OMe OMe OH H H H OMs O —CH₂C₆H₄-4-Me I-1491 OMs H H H H H OMe OMe OH H H H COOH O —CH₂CH═CMe₂ I-1492 OMs H H H H H OMe OMe OH H H H COOH O —(CH₂)₂CH═CMe₂ I-1493 OMs H H H H H OMe OMe OH H H H COOH O —CH₂CH═CCl₂ I-1494 OMs H H H H H OMe OMe OH H H H COOH O —CH₂C≡CMe I-1495 OMs H H H H H OMe OMe OH H H H COOH O —CH₂C₆H₄-4-Me

TABLE 276 I-1496 OMs H H H H H OMe OMe OH H H H CH₂OH O —CH₂CH═CMe₂ I-1497 OMs H H H H H OMe OMe OH H H H CH₂OH O —(CH₂)₂CH═CMe₂ I-1498 OMs H H H H H OMe OMe OH H H H CH₂OH O —CH₂CH═CCl₂ I-1499 OMs H H H H H OMe OMe OH H H H CH₂OH O —CH₂C≡CMe I-1500 OMs H H H H H OMe OMe OH H H H CH₂OH O —CH₂C₆H₄-4-Me I-1501 OMs H H H H H OMe OMe OH H H H F O —CH₂CH═CMe₂ I-1502 OMs H H H H H OMe OMe OH H H H F O —(CH₂)₂CH═CMe₂ I-1503 OMs H H H H H OMe OMe OH H H H F O —CH₂CH═CCl₂ I-154 OMs H H H H H OMe OMe OH H H H F O —CH₂C≡CMe I-1505 OMs H H H H H OMe OMe OH H H H F O —CH₂C₆H₄-4-Me I-1506 OMs H H H H H OMe OMe COOH H H H OH O —CH₂CH═CMe₂ I-1507 OMs H H H H H OMe OMe COOH H H H OH O —(CH₂)₂CH═CMe₂ I-1508 OMs H H H H H OMe OMe COOH H H H OH O —CH₂CH═CCl₂ I-1509 OMs H H H H H OMe OMe COOH H H H OH O —CH₂C≡CMe I-1510 OMs H H H H H OMe OMe COOH H H H OH O —CH₂C₆H₄-4-Me I-1511 OMs H H H H H OMe OMe COOH H H H OMs O —CH₂CH═CMe₂ I-1512 OMs H H H H H OMe OMe COOH H H H OMs O —(CH₂)₂CH═CMe₂ I-1513 OMs H H H H H OMe OMe COOH H H H OMs O —CH₂CH═CCl₂ I-1514 OMs H H H H H OMe OMe COOH H H H OMs O —CH₂C≡CMe I-1515 OMs H H H H H OMe OMe COOH H H H OMs O —CH₂C₆H₄-4-Me I-1516 OMs H H H H H OMe OMe COOH H H H COOH O —CH₂CH═CMe₂

TABLE 277 I-1517 OMs H H H H H OMe OMe COOH H H H COOH O —(CH₂)₂CH═CMe₂ I-1518 OMs H H H H H OMe OMe COOH H H H COOH O —CH₂CH═CCl₂ I-1519 OMs H H H H H OMe OMe COOH H H H COOH O —CH₂C≡CMe I-1520 OMs H H H H H OMe OMe COOH H H H COOH O —CH₂C₆H₄-4-Me I-1521 OMs H H H H H OMe OMe COOH H H H CH₂OH O —CH₂CH═CMe₂ I-1522 OMs H H H H H OMe OMe COOH H H H CH₂OH O —(CH₂)₂CH═CMe₂ I-1523 OMs H H H H H OMe OMe COOH H H H CH₂OH O —CH₂CH═CCl₂ I-1524 OMs H H H H H OMe OMe COOH H H H CH₂OH O —CH₂C≡CMe I-1525 OMs H H H H H OMe OMe COOH H H H CH₂OH O —CH₂C₆H₄-4-Me I-1526 OMs H H H H H OMe OMe COOH H H H F O —CH₂CH═CMe₂ I-1527 OMs H H H H H OMe OMe COOH H H H F O —(CH₂)₂CH═CMe₂ I-1528 OMs H H H H H OMe OMe COOH H H H F O —CH₂CH═CCl₂ I-1529 OMs H H H H H OMe OMe COOH H H H F O —CH₂C≡CMe I-1530 OMs H H H H H OMe OMe COOH H H H F O —CH₂C₆H₄-4-Me I-1531 OMs H H H H H OMe OMe CH₂OH H H H OH O —(CH₂)₂CH═CMe₂ I-1532 OMs H H H H H OMe OMe CH₂OH H H H OH O —CH₂CH═CCl₂ I-1533 OMs H H H H H OMe OMe CH₂OH H H H OH O —CH₂C≡CMe I-1534 OMs H H H H H OMe OMe CH₂OH H H H OH O —CH₂C₆H₄-4-Me I-1535 OMs H H H H H OMe OMe CH₂OH H H H OMs O —(CH₂)₂CH═CMe₂ I-1536 OMs H H H H H OMe OMe CH₂OH H H H OMs O —CH₂CH═CCl₂ I-1537 OMs H H H H H OMe OMe CH₂OH H H H OMs O —CH₂C≡CMe

TABLE 278 I-1538 OMs H H H H H OMe OMe CH₂OH H H H OMs O —CH₂C₆H₄-4-Me I-1539 OMs H H H H H OMe OMe CH₂OH H H H COOH O —CH₂CH═CMe₂ I-1540 OMs H H H H H OMe OMe CH₂OH H H H COOH O —(CH₂)₂CH═CMe₂ I-1541 OMs H H H H H OMe OMe CH₂OH H H H COOH O —CH₂CH═CCl₂ I-1542 OMs H H H H H OMe OMe CH₂OH H H H COOH O —CH₂C≡CMe I-1543 OMs H H H H H OMe OMe CH₂OH H H H COOH O —CH₂C₆H₄-4-Me I-1544 OMs H H H H H OMe OMe CH₂OH H H H CH₂OH O —(CH₂)₂CH═CMe₂ I-1545 OMs H H H H H OMe OMe CH₂OH H H H CH₂OH O —CH₂CH═CCl₂ I-1546 OMs H H H H H OMe OMe CH₂OH H H H CH₂OH O —CH₂C≡CMe I-1547 OMs H H H H H OMe OMe CH₂OH H H H CH₂OH O —CH₂C₆H₄-4-Me I-1548 OMs H H H H H OMe OMe CH₂OH H H H F O —CH₂CH═CMe₂ I-1549 OMs H H H H H OMe OMe CH₂OH H H H F O —(CH₂)₂CH═CMe₂ I-1550 OMs H H H H H OMe OMe CH₂OH H H H F O —CH₂CH═CCl₂ I-1551 OMs H H H H H OMe OMe CH₂OH H H H F O —CH₂C≡CMe I-1552 OMs H H H H H OMe OMe CH₂OH H H H F O —CH₂C₆H₄-4-Me I-1553 OMs H H H H H OMe OMe Me H H H OH O —CH₂CH═CMe₂ I-1554 OMs H H H H H OMe OMe Me H H H OH O —(CH₂)₂CH═CMe₂ I-1555 OMs H H H H H OMe OMe Me H H H OH O —CH₂CH═CCl₂ I-1556 OMs H H H H H OMe OMe Me H H H OH O —CH₂C≡CMe I-1557 OMs H H H H H OMe OMe Me H H H OH O —CH₂C₆H₄-4-Me I-1558 OMs H H H H H OMe OMe Me H H H OMs O —CH₂CH═CMe₂

TABLE 279 I-1559 OMs H H H H H OMe OMe Me H H H OMs O —CH₂CH═CCl₂ I-1560 OMs H H H H H OMe OMe Me H H H OMs O —CH₂C≡CMe I-1561 OMs H H H H H OMe OMe Me H H H COOH O —CH₂CH═CMe₂ I-1562 OMs H H H H H OMe OMe Me H H H COOH O —(CH₂)₂CH═CMe₂ I-1563 OMs H H H H H OMe OMe Me H H H COOH O —CH₂CH═CCl₂ I-1564 OMs H H H H H OMe OMe Me H H H COOH O —CH₂C≡CMe I-1565 OMs H H H H H OMe OMe Me H H H COOH O —CH₂C₆H₄-4-Me I-1566 OMs H H H H H OMe OMe Me H H H CH₂OH O —CH₂CH═CMe₂ I-1567 OMs H H H H H OMe OMe Me H H H CH₂OH O —(CH₂)₂CH═CMe₂ I-1568 OMs H H H H H OMe OMe Me H H H CH₂OH O —CH₂CH═CCl₂ I-1569 OMs H H H H H OMe OMe Me H H H CH₂OH O —CH₂C≡CMe I-1570 OMs H H H H H OMe OMe Me H H H CH₂OH O —CH₂C₆H₄-4-Me I-1571 OMs H H H H H OMe OMe Me H H H F O —CH₂CH═CMe₂ I-1572 OMs H H H H H OMe OMe Me H H H F O —(CH₂)₂CH═CMe₂ I-1573 OMs H H H H H OMe OMe Me H H H F O —CH₂CH═CCl₂ I-1574 OMs H H H H H OMe OMe Me H H H F O —CH₂C≡CMe I-1575 OMs H H H H H OMe OMe Me H H H F O —CH₂C₆H₄-4-Me I-1576 OMs H H H H H OMe OMe H H H H OH O —CH₂CH═CMe₂ I-1577 OMs H H H H H OMe OMe H H H H OH O —(CH₂)₂CH═CMe₂ I-1578 OMs H H H H H OMe OMe H H H H OH O —CH₂CH═CCl₂ I-1579 OMs H H H H H OMe OMe H H H H OH O —CH₂C≡CMe

TABLE 280 I-1580 OMs H H H H H OMe OMe H H H H OH O —CH₂C₆H₄-4-Me I-1581 OMs H H H H H OMe OMe H H H H OMs O —CH₂CH═CCl₂ I-1582 OMs H H H H H OMe OMe H H H H OMs O —CH₂C≡CMe I-1583 OMs H H H H H OMe OMe H H H H COOH O —CH₂CH═CMe₂ I-1584 OMs H H H H H OMe OMe H H H H COOH O —(CH₂)₂CH═CMe₂ I-1585 OMs H H H H H OMe OMe H H H H COOH O —CH₂CH═CCl₂ I-1586 OMs H H H H H OMe OMe H H H H COOH O —CH₂C≡CMe I-1587 OMs H H H H H OMe OMe H H H H COOH O —CH₂C₆H₄-4-Me I-1588 OMs H H H H H OMe OMe H H H H CH₂OH O —CH₂CH═CMe₂ I-1589 OMs H H H H H OMe OMe H H H H CH₂OH O —(CH₂)₂CH═CMe₂ I-1590 OMs H H H H H OMe OMe H H H H CH₂OH O —CH₂CH═CCl₂ I-1591 OMs H H H H H OMe OMe H H H H CH₂OH O —CH₂C≡CMe I-1592 OMs H H H H H OMe OMe H H H H CH₂OH O —CH₂C₆H₄-4-Me I-1593 OMs H H H H H OMe OMe H H H H F O —(CH₂)₂CH═CMe₂ I-1594 OMs H H H H H OMe OMe H H H H F O —CH₂CH═CCl₂ I-1595 OMs H H H H H OMe OMe H H H H F O —CH₂C≡CMe I-1596 OMs H H H H F OMe OMe OH H H H OH O —CH₂CH═CMe₂ I-1597 OMs H H H H F OMe OMe OH H H H OH O —(CH₂)₂CH═CMe₂ I-1598 OMs H H H H F OMe OMe OH H H H OH O —CH₂CH═CCl₂ I-1599 OMs H H H H F OMe OMe OH H H H OH O —CH₂C≡CMe I-1600 OMs H H H H F OMe OMe OH H H H OH O —CH₂C₆H₄-4-Me

TABLE 281 I-1601 OMs H H H H F OMe OMe OH H H H OMs O —CH₂CH═CMe₂ I-1602 OMs H H H H F OMe OMe OH H H H OMs O —(CH₂)₂CH═CMe₂ I-1603 OMs H H H H F OMe OMe OH H H H OMs O —CH₂CH═CCl₂ I-1604 OMs H H H H F OMe OMe OH H H H OMs O —CH₂C≡CMe I-1605 OMs H H H H F OMe OMe OH H H H OMs O —CH₂C₆H₄-4-Me I-1606 OMs H H H H F OMe OMe OH H H H COOH O —CH₂CH═CMe₂ I-1607 OMs H H H H F OMe OMe OH H H H COOH O —(CH₂)₂CH═CMe₂ I-1608 OMs H H H H F OMe OMe OH H H H COOH O —CH₂CH═CCl₂ I-1609 OMs H H H H F OMe OMe OH H H H COOH O —CH₂C≡CMe I-1610 OMs H H H H F OMe OMe OH H H H COOH O —CH₂C₆H₄-4-Me I-1611 OMs H H H H F OMe OMe OH H H H CH₂OH O —CH₂CH═CMe₂ I-1612 OMs H H H H F OMe OMe OH H H H CH₂OH O —(CH₂)₂CH═CMe₂ I-1613 OMs H H H H F OMe OMe OH H H H CH₂OH O —CH₂CH═CCl₂ I-1614 OMs H H H H F OMe OMe OH H H H CH₂OH O —CH₂C≡CMe I-1615 OMs H H H H F OMe OMe OH H H H CH₂OH O —CH₂C₆H₄-4-Me I-1616 OMs H H H H F OMe OMe OH H H H F O —CH₂CH═CMe₂ I-1617 OMs H H H H F OMe OMe OH H H H F O —(CH₂)₂CH═CMe₂ I-1618 OMs H H H H F OMe OMe OH H H H F O —CH₂CH═CCl₂ I-1619 OMs H H H H F OMe OMe OH H H H F O —CH₂C≡CMe I-1620 OMs H H H H F OMe OMe OH H H H F O —CH₂C₆H₄-4-Me I-1621 F H H H H H OMe OMe OH H H H OH O —CH₂CH═CCl₂

TABLE 282 I-1622 F H H H H H OMe OMe OH H H H OH O —CH₂C≡CMe I-1623 F H H H H H OMe OMe OH H H H OMs O —CH₂CH═CCl₂ I-1624 F H H H H H OMe OMe OH H H H OMs O —CH₂C≡CMe I-1625 F H H H H H OMe OMe OH H H H COOH O —CH₂CH═CMe₂ I-1626 F H H H H H OMe OMe OH H H H COOH O —(CH₂)₂CH═CMe₂ I-1627 F H H H H H OMe OMe OH H H H COOH O —CH₂CH═CCl₂ I-1628 F H H H H H OMe OMe OH H H H COOH O —CH₂C≡CMe I-1629 F H H H H H OMe OMe OH H H H COOH O —CH₂C₆H₄-4-Me I-1630 F H H H H H OMe OMe OH H H H CH₂OH O —CH₂CH═CMe₂ I-1631 F H H H H H OMe OMe OH H H H CH₂OH O —(CH₂)₂CH═CMe₂ I-1632 F H H H H H OMe OMe OH H H H CH₂OH O —CH₂CH═CCl₂ I-1633 F H H H H H OMe OMe OH H H H CH₂OH O —CH₂C≡CMe I-1634 F H H H H H OMe OMe OH H H H CH₂OH O —CH₂C₆H₄-4-Me I-1635 F H H H H H OMe OMe OH H H H F O —CH₂CH═CCl₂ I-1636 F H H H H H OMe OMe OH H H H F O —CH₂C≡CMe I-1637 F H H H H H OMe OMe COOH H H H OH O —CH₂CH═CCl₂ I-1638 F H H H H H OMe OMe COOH H H H OH O —CH₂C≡CMe I-1639 F H H H H H OMe OMe COOH H H H OMs O —CH₂CH═CMe₂ I-1640 F H H H H H OMe OMe COOH H H H OMs O —(CH₂)₂CH═CMe₂ I-1641 F H H H H H OMe OMe COOH H H H OMs O —CH₂CH═CCl₂ I-1642 F H H H H H OMe OMe COOH H H H OMs O —CH₂C≡CMe

TABLE 283 I-1643 F H H H H H OMe OMe COOH H H H OMs O —CH₂C₆H₄-4-Me I-1644 F H H H H H OMe OMe COOH H H H COOH O —CH₂CH═CMe₂ I-1645 F H H H H H OMe OMe COCH H H H COOH O —(CH₂)₂CH═CMe₂ I-1646 F H H H H H OMe OMe COOH H H H COOH O —CH₂CH═CCl₂ I-1647 F H H H H H OMe OMe COOH H H H COOH O —CH₂C≡CMe I-1648 F H H H H H OMe OMe COOH H H H COOH O —CH₂C₆H₄-4-Me I-1649 F H H H H H OMe OMe COOH H H H CH₂OH O —CH₂CH═CMe₂ I-1650 F H H H H H OMe OMe COOH H H H CH₂OH O —(CH₂)₂CH═CMe₂ I-1651 F H H H H H OMe OMe COOH H H H CH₂OH O —CH₂CH═CCl₂ I-1652 F H H H H H OMe OMe COOH H H H CH₂OH O —CH₂C≡CMe I-1653 F H H H H H OMe OMe COOH H H H CH₂OH O —CH₂C₆H₄-4-Me I-1654 F H H H H H OMe OMe COOH H H H F O —CH₂CH═CCl₂ I-1655 F H H H H H OMe OMe COOH H H H F O —CH₂C≡CMe I-1656 F H H H H H OMe OMe CH₂OH H H H OH O —CH₂CH═CMe₂ I-1657 F H H H H H OMe OMe CH₂OH H H H OH O —(CH₂)₂CH═CMe₂ I-1658 F H H H H H OMe OMe CH₂OH H H H OH O —CH₂CH═CCl₂ I-1659 F H H H H H OMe OMe CH₂OH H H H OH O —CH₂C≡CMe I-1660 F H H H H H OMe OMe CH₂OH H H H OH O —CH₂C₆H₄-4-Me I-1661 F H H H H H OMe OMe CH₂OH H H H OMs O —CH₂CH═CMe₂ I-1662 F H H H H H OMe OMe CH₂OH H H H OMs O —(CH₂)₂CH═CMe₂ I-1663 F H H H H H OMe OMe CH₂OH H H H OMs O —CH₂CH═CCl₂

TABLE 284 I-1664 F H H H H H OMe OMe CH₂OH H H H OMs O —CH₂C≡CMe I-1665 F H H H H H OMe OMe CH₂OH H H H OMs O —CH₂C₆H₄-4-Me I-1666 F H H H H H OMe OMe CH₂OH H H H COOH O —CH₂CH═CMe₂ I-1667 F H H H H H OMe OMe CH₂OH H H H COOH O —(CH₂)₂CH═CMe₂ I-1668 F H H H H H OMe OMe CH₂OH H H H COOH O —CH₂CH═CCl₂ I-1669 F H H H H H OMe OMe CH₂OH H H H COOH O —CH₂C≡CMe I-1670 F H H H H H OMe OMe CH₂OH H H H COOH O —CH₂C₆H₄-4-Me I-1671 F H H H H H OMe OMe CH₂OH H H H CH₂OH O —CH₂CH═CMe₂ I-1672 F H H H H H OMe OMe CH₂OH H H H CH₂OH O —(CH₂)₂CH═CMe₂ I-1673 F H H H H H OMe OMe CH₂OH H H H CH₂OH O —CH₂CH═CCl₂ I-1674 F H H H H H OMe OMe CH₂OH H H H CH₂OH O —CH₂C≡CMe I-1675 F H H H H H OMe OMe CH₂OH H H H CH₂OH O —CH₂C₆H₄-4-Me I-1676 F H H H H H OMe OMe CH₂OH H H H F O —CH₂CH═CMe₂ I-1677 F H H H H H OMe OMe CH₂OH H H H F O —(CH₂)₂CH═CMe₂ I-1678 F H H H H H OMe OMe CH₂OH H H H F O —CH₂CH═CCl₂ I-1679 F H H H H H OMe OMe CH₂OH H H H F O —CH₂C≡CMe I-1680 F H H H H H OMe OMe CH₂OH H H H F O —CH₂C₆H₄-4-Me I-1681 F H H H H H OMe OMe Me H H H OH O —CH₂CH═CMe₂ I-1682 F H H H H H OMe OMe Me H H H OH O —(CH₂)₂CH═CMe₂ I-1683 F H H H H H OMe OMe Me H H H OH O —CH₂CH═CCl₂ I-1684 F H H H H H OMe OMe Me H H H OH O —CH₂C≡CMe

TABLE 285 I-1685 F H H H H H OMe OMe Me H H H OH O —CH₂C₆H₄-4-Me I-1686 F H H H H H OMe OMe Me H H H OMs O —CH₂CH═CMe₂ I-1687 F H H H H H OMe OMe Me H H H OMs O —(CH₂)₂CH═CMe₂ I-1688 F H H H H H OMe OMe Me H H H OMs O —CH₂CH═CCl₂ I-1689 F H H H H H OMe OMe Me H H H OMs O —CH₂C≡CMe I-1690 F H H H H H OMe OMe Me H H H OMs O —CH₂C₆H₄-4-Me I-1691 F H H H H H OMe OMe Me H H H COOH O —CH₂CH═CMe₂ I-1692 F H H H H H OMe OMe Me H H H COOH O —(CH₂)₂CH═CMe₂ I-1693 F H H H H H OMe OMe Me H H H COOH O —CH₂CH═CCl₂ I-1694 F H H H H H OMe OMe Me H H H COOH O —CH₂C≡CMe I-1695 F H H H H H OMe OMe Me H H H COOH O —CH₂C₆H₄-4-Me I-1696 F H H H H H OMe OMe Me H H H CH₂OH O —CH₂CH═CMe₂ I-1697 F H H H H H OMe OMe Me H H H CH₂OH O —(CH₂)₂CH═CMe₂ I-1698 F H H H H H OMe OMe Me H H H CH₂OH O —CH₂CH═CCl₂ I-1699 F H H H H H OMe OMe Me H H H CH₂OH O —CH₂C≡CMe I-1700 F H H H H H OMe OMe Me H H H CH₂OH O —CH₂C₆H₄-4-Me I-1701 F H H H H H OMe OMe Me H H H F O —CH₂CH═CMe₂ I-1702 F H H H H H OMe OMe Me H H H F O —(CH₂)₂CH═CMe₂ I-1703 F H H H H H OMe OMe Me H H H F O —CH₂CH═CCl₂ I-1704 F H H H H H OMe OMe Me H H H F O —CH₂C≡CMe I-1705 F H H H H H OMe OMe Me H H H F O —CH₂C₆H₄-4-Me

TABLE 286 I-1706 F H H H H H OMe OMe H H H H OH O —CH₂CH═CMe₂ I-1707 F H H H H H OMe OMe H H H H OH O —(CH₂)₂CH═CMe₂ I-1708 F H H H H H OMe OMe H H H H OH O —CH₂CH═CCl₂ I-1709 F H H H H H OMe OMe H H H H OH O —CH₂C≡CMe I-1710 F H H H H H OMe OMe H H H H OH O —CH₂C₆H₄-4-Me I-1711 F H H H H H OMe OMe H H H H OMs O —(CH₂)₂CH═CMe₂ I-1712 F H H H H H OMe OMe H H H H OMs O —CH₂CH═CCl₂ I-1713 F H H H H H OMe OMe H H H H OMs O —CH₂C≡CMe I-1714 F H H H H H OMe OMe H H H H OMs O —CH₂C₆H₄-4-Me I-1715 F H H H H H OMe OMe H H H H COOH O —CH₂CH═CMe₂ I-1716 F H H H H H OMe OMe H H H H COOH O —(CH₂)₂CH═CMe₂ I-1717 F H H H H H OMe OMe H H H H COOH O —CH₂CH═CCl₂ I-1718 F H H H H H OMe OMe H H H H COOH O —CH₂C≡CMe I-1719 F H H H H H OMe OMe H H H H COOH O —CH₂C₆H₄-4-Me I-1720 F H H H H H OMe OMe H H H H CH₂OH O —CH₂CH═CMe₂ I-1721 F H H H H H OMe OMe H H H H CH₂OH O —(CH₂)₂CH═CMe₂ I-1722 F H H H H H OMe OMe H H H H CH₂OH O —CH₂CH═CCl₂ I-1723 F H H H H H OMe OMe H H H H CH₂OH O —CH₂C≡CMe I-1724 F H H H H H OMe OMe H H H H CH₂OH O —CH₂C₆H₄-4-Me I-1725 F H H H H H OMe OMe H H H H F O —CH₂CH═CMe₂ I-1726 F H H H H H OMe OMe H H H H F O —(CH₂)₂CH═CMe₂

TABLE 287 I-1727 F H H H H H OMe OMe H H H H F O —CH₂CH═CCl₂ I-1728 F H H H H H OMe OMe H H H H F O —CH₂C≡CMe I-1729 F H H H H H OMe OMe H H H H F O —CH₂C₆H₄-4-Me I-1730 F H H H H F OMe OMe OH H H H OH O —(CH₂)₂CH═CMe₂ I-1731 F H H H H F OMe OMe OH H H H OH O —CH₂CH═CCl₂ I-1732 F H H H H F OMe OMe OH H H H OH O —CH₂C≡CMe I-1733 F H H H H F OMe OMe OH H H H OH O —CH₂C₆H₄-4-Me I-1734 F H H H H F OMe OMe OH H H H OMs O —CH₂CH═CMe₂ I-1735 F H H H H F OMe OMe OH H H H OMs O —(CH₂)₂CH═CMe₂ I-1736 F H H H H F OMe OMe OH H H H OMs O —CH₂CH═CCl₂ I-1737 F H H H H F OMe OMe OH H H H OMs O —CH₂C≡CMe I-1738 F H H H H F OMe OMe OH H H H OMs O —CH₂C₆H₄-4-Me I-1739 F H H H H F OMe OMe OH H H H COOH O —CH₂CH═CMe₂ I-1740 F H H H H F OMe OMe OH H H H COOH O —(CH₂)₂CH═CMe₂ I-1741 F H H H H F OMe OMe OH H H H COOH O —CH₂CH═CCl₂ I-1742 F H H H H F OMe OMe OH H H H COOH O —CH₂C≡CMe I-1743 F H H H H F OMe OMe OH H H H COOH O —CH₂C₆H₄-4-Me I-1744 F H H H H F OMe OMe OH H H H CH₂OH O —CH₂CH═CMe₂ I-1745 F H H H H F OMe OMe OH H H H CH₂OH O —(CH₂)₂CH═CMe₂ I-1746 F H H H H F OMe OMe OH H H H CH₂OH O —CH₂CH═CCl₂ I-1747 F H H H H F OMe OMe OH H H H CH₂OH O —CH₂C≡CMe

TABLE 288 I-1748 F H H H H F OMe OMe OH H H H CH₂OH O —CH₂C₆H₄-4-Me I-1749 F H H H H F OMe OMe OH H H H F O —CH₂CH═CMe₂ I-1750 F H H H H F OMe OMe OH H H H F O —(CH₂)₂CH═CMe₂ I-1751 F H H H H F OMe OMe OH H H H F O —CH₂CH═CCl₂ I-1752 F H H H H F OMe OMe OH H H H F O —CH₂C≡CMe I-1753 F H H H H F OMe OMe OH H H H F O —CH₂C₆H₄-4-Me I-1754 —OCH₂O— * H H * H H OMe OMe OH H H H OH O —CH₂CH═CMe₂ I-1755 —OCH₂O— * H H * H H OMe OMe OH H H H OH O —(CH₂)₂CH═CMe₂ I-1756 —OCH₂O— * H H * H H OMe OMe OH H H H OH O —CH₂CH═CCl₂ I-1757 —OCH₂O— * H H * H H OMe OMe OH H H H OH O —CH₂C≡CMe I-1758 —OCH₂O— * H H * H H OMe OMe OH H H H OH O —CH₂C₆H₄-4-Me I-1759 —OCH₂O— * H H * H H OMe OMe OH H H H OMs O —CH₂CH═CMe₂ I-1760 —OCH₂O— * H H * H H OMe OMe OH H H H OMs O —(CH₂)₂CH═CMe₂ I-1761 —OCH₂O— * H H * H H OMe OMe OH H H H OMs O —CH₂CH═CCl₂ I-1762 —OCH₂O— * H H * H H OMe OMe OH H H H OMs O —CH₂C≡CMe I-1763 —OCH₂O— * H H * H H OMe OMe OH H H H OMs O —CH₂C₆H₄-4-Me I-1764 —OCH₂O— * H H * H H OMe OMe OH H H H COOH O —CH₂CH═CMe₂ I-1765 —OCH₂O— * H H * H H OMe OMe OH H H H COOH O —(CH₂)₂CH═CMe₂ I-1766 —OCH₂O— * H H * H H OMe OMe OH H H H COOH O —CH₂CH═CCl₂ I-1767 —OCH₂O— * H H * H H OMe OMe OH H H H COOH O —CH₂C≡CMe I-1768 —OCH₂O— * H H * H H OMe OMe OH H H H COOH O —CH₂C₆H₄-4-Me

TABLE 289 I-1768 —OCH₂O— * H H * H H OMe OMe OH H H H CH₂OH O —CH₂CH═CMe₂ I-1769 —OCH₂O— * H H * H H OMe OMe OH H H H CH₂OH O —(CH₂)₂CH═CMe₂ I-1770 —OCH₂O— * H H * H H OMe OMe OH H H H CH₂OH O —CH₂CH═CCl₂ I-1771 —OCH₂O— * H H * H H OMe OMe OH H H H CH₂OH O —CH₂C≡CMe I-1772 —OCH₂O— * H H * H H OMe OMe OH H H H CH₂OH O —CH₂C₆H₄-4-Me I-1773 —OCH₂O— * H H * H H OMe OMe OH H H H F O —CH₂CH═CMe₂ I-1774 —OCH₂O— * H H * H H OMe OMe OH H H H F O —(CH₂)₂CH═CMe₂ I-1775 —OCH₂O— * H H * H H OMe OMe OH H H H F O —CH₂CH═CCl₂ I-1776 —OCH₂O— * H H * H H OMe OMe OH H H H F O —CH₂C≡CMe I-1777 —OCH₂O— * H H * H H OMe OMe OH H H H F O —CH₂C₆H₄-4-Me I-1778 —OCH₂O— * H H * H H OMe OMe COOH H H H OH O —CH₂CH═CMe₂ I-1779 —OCH₂O— * H H * H H OMe OMe COOH H H H OH O —(CH₂)₂CH═CMe₂ I-1780 —OCH₂O— * H H * H H OMe OMe COOH H H H OH O —CH₂CH═CCl₂ I-1781 —OCH₂O— * H H * H H OMe OMe COOH H H H OH O —CH₂C≡CMe I-1782 —OCH₂O— * H H * H H OMe OMe COOH H H H OH O —CH₂C₆H₄-4-Me I-1783 —OCH₂O— * H H * H H OMe OMe COOH H H H OMs O —CH₂CH═CMe₂ I-1784 —OCH₂O— * H H * H H OMe OMe COOH H H H OMs O —(CH₂)₂CH═CMe₂ I-1785 —OCH₂O— * H H * H H OMe OMe COOH H H H OMs O —CH₂CH═CCl₂ I-1786 —OCH₂O— * H H * H H OMe OMe COOH H H H OMs O —CH₂C≡CMe I-1787 —OCH₂O— * H H * H H OMe OMe COOH H H H OMs O —CH₂C₆H₄-4-Me I-1788 —OCH₂O— * H H * H H OMe OMe COOH H H H COOH O —CH₂CH═CMe₂

TABLE 290 I-1789 —OCH₂O—* H H * H H OMe OMe COOH H H H COOH O —(CH₂)₂CH═CMe₂ I-1790 —OCH₂O—* H H * H H OMe OMe COOH H H H COOH O —CH₂CH═CCl₂ I-1791 —OCH₂O—* H H * H H OMe OMe COOH H H H COOH O —CH₂C≡CMe I-1792 —OCH₂O—* H H * H H OMe OMe COOH H H H COOH O —CH₂C₆H₄-4-Me I-1793 —OCH₂O—* H H * H H OMe OMe COOH H H H CH₂OH O —CH₂CH═CMe₂ I-1794 —OCH₂O—* H H * H H OMe OMe COOH H H H CH₂OH O —(CH₂)₂CH═CMe₂ I-1795 —OCH₂O—* H H * H H OMe OMe COOH H H H CH₂OH O —CH₂CH═CCl₂ I-1796 —OCH₂O—* H H * H H OMe OMe COOH H H H CH₂OH O —CH₂C≡CMe I-1797 —OCH₂O—* H H * H H OMe OMe COOH H H H CH₂OH O —CH₂C₆H₄-4-Me I-1798 —OCH₂O—* H H * H H OMe OMe COOH H H H F O —CH₂CH═CMe₂ I-1799 —OCH₂O—* H H * H H OMe OMe COOH H H H F O —(CH₂)₂CH═CMe₂ I-1800 —OCH₂O—* H H * H H OMe OMe COOH H H H F O —CH₂CH═CCl₂ I-1801 —OCH₂O—* H H * H H OMe OMe COOH H H H F O —CH₂C≡CMe I-1802 —OCH₂O—* H H * H H OMe OMe COOH H H H F O —CH₂C₆H₄-4-Me I-1803 —OCH₂O—* H H * H H OMe OMe CH₂OH H H H OH O —CH₂CH═CMe₂ I-1804 —OCH₂O—* H H * H H OMe OMe CH₂OH H H H OH O —(CH₂)₂CH═CMe₂ I-1805 —OCH₂O—* H H * H H OMe OMe CH₂OH H H H OH O —CH₂CH═CCl₂ I-1806 —OCH₂O—* H H * H H OMe OMe CH₂OH H H H OH O —CH₂C≡CMe I-1807 —OCH₂O—* H H * H H OMe OMe CH₂OH H H H OH O —CH₂C₆H₄-4-Me I-1808 —OCH₂O—* H H * H H OMe OMe CH₂OH H H H OMs O —CH₂CH═CMe₂ I-1809 —OCH₂O—* H H * H H OMe OMe CH₂OH H H H OMs O —(CH₂)₂CH═CMe₂

TABLE 291 I-1810 —OCH₂O—* H H * H H OMe OMe CH₂OH H H H OMs O —CH₂CH═CCl₂ I-1811 —OCH₂O—* H H * H H OMe OMe CH₂OH H H H OMs O —CH₂C≡CMe I-1812 —OCH₂O—* H H * H H OMe OMe CH₂OH H H H OMs O —CH₂C₆H₄-4-Me I-1813 —OCH₂O—* H H * H H OMe OMe CH₂OH H H H COOH O —CH₂CH═CMe₂ I-1814 —OCH₂O—* H H * H H OMe OMe CH₂OH H H H COOH O —(CH₂)₂CH═CMe₂ I-1815 —OCH₂O—* H H * H H OMe OMe CH₂OH H H H COOH O —CH₂CH═CCl₂ I-1816 —OCH₂O—* H H * H H OMe OMe CH₂OH H H H COOH O —CH₂C≡CMe I-1817 —OCH₂O—* H H * H H OMe OMe CH₂OH H H H COOH O —CH₂C₆H₄-4-Me I-1818 —OCH₂O—* H H * H H OMe OMe CH₂OH H H H CH₂OH O —CH₂CH═CMe₂ I-1819 —OCH₂O—* H H * H H OMe OMe CH₂OH H H H CH₂OH O —(CH₂)₂CH═CMe₂ I-1820 —OCH₂O—* H H * H H OMe OMe CH₂OH H H H CH₂OH O —CH₂CH═CCl₂ I-1821 —OCH₂O—* H H * H H OMe OMe CH₂OH H H H CH₂OH O —CH₂C≡CMe I-1822 —OCH₂O—* H H * H H OMe OMe CH₂OH H H H CH₂OH O —CH₂C₆H₄-4-Me I-1823 —OCH₂O—* H H * H H OMe OMe CH₂OH H H H F O —CH₂CH═CMe₂ I-1824 —OCH₂O—* H H * H H OMe OMe CH₂OH H H H F O —(CH₂)₂CH═CMe₂ I-1825 —OCH₂O—* H H * H H OMe OMe CH₂OH H H H F O —CH₂CH═CCl₂ I-1826 —OCH₂O—* H H * H H OMe OMe CH₂OH H H H F O —CH₂C≡CMe I-1827 —OCH₂O—* H H * H H OMe OMe CH₂OH H H H F O —CH₂C₆H₄-4-Me I-1828 —OCH₂O—* H H * H H OMe OMe Me H H H OH O —CH₂CH═CMe₂ I-1829 —OCH₂O—* H H * H H OMe OMe Me H H H OH O —(CH₂)₂CH═CMe₂ I-1830 —OCH₂O—* H H * H H OMe OMe Me H H H OH O —CH₂CH═CCl₂

TABLE 292 I-1831 —OCH₂O—* H H * H H OMe OMe Me H H H OH O —CH₂C≡CMe I-1832 —OCH₂O—* H H * H H OMe OMe Me H H H OH O —CH₂C₆H₄-4-Me I-1833 —OCH₂O—* H H * H H OMe OMe Me H H H OMs O —CH₂CH═CMe₂ I-1834 —OCH₂O—* H H * H H OMe OMe Me H H H OMs O —(CH₂)₂CH═CMe₂ I-1835 —OCH₂O—* H H * H H OMe OMe Me H H H OMs O —CH₂CH═CCl₂ I-1836 —OCH₂O—* H H * H H OMe OMe Me H H H OMs O —CH₂C≡CMe I-1837 —OCH₂O—* H H * H H OMe OMe Me H H H OMs O —CH₂C₆H₄-4-Me I-1838 —OCH₂O—* H H * H H OMe OMe Me H H H COOH O —CH₂CH═CMe₂ I-1839 —OCH₂O—* H H * H H OMe OMe Me H H H COOH O —(CH₂)₂CH═CMe₂ I-1840 —OCH₂O—* H H * H H OMe OMe Me H H H COOH O —CH₂CH═CCl₂ I-1841 —OCH₂O—* H H * H H OMe OMe Me H H H COOH O —CH₂C≡CMe I-1842 —OCH₂O—* H H * H H OMe OMe Me H H H COOH O —CH₂C₆H₄-4-Me I-1843 —OCH₂O—* H H * H H OMe OMe Me H H H CH₂OH O —CH₂CH═CMe₂ I-1844 —OCH₂O—* H H * H H OMe OMe Me H H H CH₂OH O —(CH₂)₂CH═CMe₂ I-1845 —OCH₂O—* H H * H H OMe OMe Me H H H CH₂OH O —CH₂CH═CCl₂ I-1846 —OCH₂O—* H H * H H OMe OMe Me H H H CH₂OH O —CH₂C≡CMe I-1847 —OCH₂O—* H H * H H OMe OMe Me H H H CH₂OH O —CH₂C₆H₄-4-Me I-1848 —OCH₂O—* H H * H H OMe OMe Me H H H F O —CH₂CH═CMe₂ I-1849 —OCH₂O—* H H * H H OMe OMe Me H H H F O —(CH₂)₂CH═CMe₂ I-1850 —OCH₂O—* H H * H H OMe OMe Me H H H F O —CH₂CH═CCl₂ I-1851 —OCH₂O—* H H * H H OMe OMe Me H H H F O —CH₂C≡CMe

TABLE 293 I-1852 —OCH₂O—* H H * H H OMe OMe Me H H H F O —CH₂C₆H₄-4-Me I-1853 —OCH₂O—* H H * H H OMe OMe H H H H OH O —CH₂CH═CMe₂ I-1854 —OCH₂O—* H H * H H OMe OMe H H H H OH O —(CH₂)₂CH═CMe₂ I-1855 —OCH₂O—* H H * H H OMe OMe H H H H OH O —CH₂CH═CCl₂ I-1856 —OCH₂O—* H H * H H OMe OMe H H H H OH O —CH₂C≡CMe I-1857 —OCH₂O—* H H * H H OMe OMe H H H H OH O —CH₂C₆H₄-4-Me I-1858 —OCH₂O—* H H * H H OMe OMe H H H H OMs O —CH₂CH═CMe₂ I-1859 —OCH₂O—* H H * H H OMe OMe H H H H OMs O —(CH₂)₂CH═CMe₂ I-1860 —OCH₂O—* H H * H H OMe OMe H H H H OMs O —CH₂CH═CCl₂ I-1861 —OCH₂O—* H H * H H OMe OMe H H H H OMs O —CH₂C≡CMe I-1862 —OCH₂O—* H H * H H OMe OMe H H H H OMs O —CH₂C₆H₄-4-Me I-1863 —OCH₂O—* H H * H H OMe OMe H H H H COOH O —CH₂CH═CMe₂ I-1864 —OCH₂O—* H H * H H OMe OMe H H H H COOH O —(CH₂)₂CH═CMe₂ I-1865 —OCH₂O—* H H * H H OMe OMe H H H H COOH O —CH₂CH═CCl₂ I-1866 —OCH₂O—* H H * H H OMe OMe H H H H COOH O —CH₂C≡CMe I-1867 —OCH₂O—* H H * H H OMe OMe H H H H COOH O —CH₂C₆H₄-4-Me I-1868 —OCH₂O—* H H * H H OMe OMe H H H H CH₂OH O —CH₂CH═CMe₂ I-1869 —OCH₂O—* H H * H H OMe OMe H H H H CH₂OH O —(CH₂)₂CH═CMe₂ I-1870 —OCH₂O—* H H * H H OMe OMe H H H H CH₂OH O —CH₂CH═CCl₂ I-1871 —OCH₂O—* H H * H H OMe OMe H H H H CH₂OH O —CH₂C≡CMe I-1872 —OCH₂O—* H H * H H OMe OMe H H H H CH₂OH O —CH₂C₆H₄-4-Me

TABLE 294 I-1873 —OCH₂O—* H H * H H OMe OMe H H H H F O —CH₂CH═CMe₂ I-1874 —OCH₂O—* H H * H H OMe OMe H H H H F O —(CH₂)₂CH═CMe₂ I-1875 —OCH₂O—* H H * H H OMe OMe H H H H F O —CH₂CH═CCl₂ I-1876 —OCH₂O—* H H * H H OMe OMe H H H H F O —CH₂C≡CMe I-1877 —OCH₂O—* H H * H H OMe OMe H H H H F O —CH₂C₆H₄-4-Me I-1878 —OCH₂O—* H H * H F OMe OMe OH H H H OH O —CH₂CH═CMe₂ I-1879 —OCH₂O—* H H * H F OMe OMe OH H H H OH O —(CH₂)₂CH═CMe₂ I-1880 —OCH₂O—* H H * H F OMe OMe OH H H H OH O —CH₂CH═CCl₂ I-1881 —OCH₂O—* H H * H F OMe OMe OH H H H OH O —CH₂C≡CMe I-1882 —OCH₂O—* H H * H F OMe OMe OH H H H OH O —CH₂C₆H₄-4-Me I-1883 —OCH₂O—* H H * H F OMe OMe OH H H H OMs O —CH₂CH═CMe₂ I-1884 —OCH₂O—* H H * H F OMe OMe OH H H H OMs O —(CH₂)₂CH═CMe₂ I-1885 —OCH₂O—* H H * H F OMe OMe OH H H H OMs O —CH₂CH═CCl₂ I-1886 —OCH₂O—* H H * H F OMe OMe OH H H H OMs O —CH₂C≡CMe I-1887 —OCH₂O—* H H * H F OMe OMe OH H H H OMs O —CH₂C₆H₄-4-Me I-1888 —OCH₂O—* H H * H F OMe OMe OH H H H COOH O —CH₂CH═CMe₂ I-1889 —OCH₂O—* H H * H F OMe OMe OH H H H COOH O —(CH₂)₂CH═CMe₂ I-1890 —OCH₂O—* H H * H F OMe OMe OH H H H COOH O —CH₂CH═CCl₂ I-1891 —OCH₂O—* H H * H F OMe OMe OH H H H COOH O —CH₂C≡CMe I-1892 —OCH₂O—* H H * H F OMe OMe OH H H H COOH O —CH₂C₆H₄-4-Me I-1893 —OCH₂O—* H H * H F OMe OMe OH H H H CH₂OH O —CH₂CH═CMe₂

TABLE 295 I-1894 —OCH₂O—* H H * H F OMe OMe OH H H H CH₂OH O —(CH₂)₂CH═CMe₂ I-1895 —OCH₂O—* H H * H F OMe OMe OH H H H CH₂OH O —CH₂CH═CCl₂ I-1896 —OCH₂O—* H H * H F OMe OMe OH H H H CH₂OH O —CH₂C≡CMe I-1897 —OCH₂O—* H H * H F OMe OMe OH H H H CH₂OH O —CH₂C₆H₄-4-Me I-1898 —OCH₂O—* H H * H F OMe OMe OH H H H F O —CH₂CH═CMe₂ I-1899 —OCH₂O—* H H * H F OMe OMe OH H H H F O —(CH₂)₂CH═CMe₂ I-1900 —OCH₂O—* H H * H F OMe OMe OH H H H F O —CH₂CH═CCl₂ I-1901 —OCH₂O—* H H * H F OMe OMe OH H H H F O —CH₂C≡CMe I-1902 —OCH₂O—* H H * H F OMe OMe OH H H H F O —CH₂C₆H₄-4-Me I-1903 NMe₂ H H H H H OMe OMe OH H H H OH O —(CH₂)₂CH═CMe₂ I-1904 NMe₂ H H H H H OMe OMe OH H H H OH O —CH₂CH═CCl₂ I-1905 NMe₂ H H H H H OMe OMe OH H H H OH O —CH₂C≡CMe I-1906 NMe₂ H H H H H OMe OMe OH H H H OMs O —CH₂CH═CMe₂ I-1907 NMe₂ H H H H H OMe OMe OH H H H OMs O —(CH₂)₂CH═CMe₂ I-1908 NMe₂ H H H H H OMe OMe OH H H H OMs O —CH₂CH═CCl₂ I-1909 NMe₂ H H H H H OMe OMe OH H H H OMs O —CH₂C≡CMe I-1910 NMe₂ H H H H H OMe OMe OH H H H OMs O —CH₂C₆H₄-4-Me I-1911 NMe₂ H H H H H OMe OMe OH H H H COOH O —CH₂CH═CMe₂ I-1912 NMe₂ H H H H H OMe OMe OH H H H COOH O —(CH₂)₂CH═CMe₂ I-1913 NMe₂ H H H H H OMe OMe OH H H H COOH O —CH₂CH═CCl₂ I-1914 NMe₂ H H H H H OMe OMe OH H H H COOH O —CH₂C≡CMe

TABLE 296 I-1915 NMe₂ H H H H H OMe OMe OH H H H COOH O —CH₂C₆H₄-4-Me I-1916 NMe₂ H H H H H OMe OMe OH H H H CH₂OH O —CH₂CH═CMe₂ I-1917 NMe₂ H H H H H OMe OMe OH H H H CH₂OH O —(CH₂)₂CH═CMe₂ I-1918 NMe₂ H H H H H OMe OMe OH H H H CH₂OH O —CH₂CH═CCl₂ I-1919 NMe₂ H H H H H OMe OMe OH H H H CH₂OH O —CH₂C≡CMe I-1920 NMe₂ H H H H H OMe OMe OH H H H CH₂OH O —CH₂C₆H₄-4-Me I-1921 NMe₂ H H H H H OMe OMe OH H H H F O —CH₂CH═CMe₂ I-1922 NMe₂ H H H H H OMe OMe OH H H H F O —(CH₂)₂CH═CMe₂ I-1923 NMe₂ H H H H H OMe OMe OH H H H F O —CH₂CH═CCl₂ I-1924 NMe₂ H H H H H OMe OMe OH H H H F O —CH₂C≡CMe I-1925 NMe₂ H H H H H OMe OMe OH H H H F O —CH₂C₆H₄-4-Me I-1926 NMe₂ H H H H H OMe OMe COOH H H H OH O —CH₂CH═CMe₂ I-1927 NMe₂ H H H H H OMe OMe COOH H H H OH O —(CH₂)₂CH═CMe₂ I-1928 NMe₂ H H H H H OMe OMe COOH H H H OH O —CH₂CH═CCl₂ I-1929 NMe₂ H H H H H OMe OMe COOH H H H OH O —CH₂C≡CMe I-1930 NMe₂ H H H H H OMe OMe COOH H H H OH O —CH₂C₆H₄-4-Me I-1931 NMe₂ H H H H H OMe OMe COOH H H H OMs O —CH₂CH═CMe₂ I-1932 NMe₂ H H H H H OMe OMe COOH H H H OMs O —(CH₂)₂CH═CMe₂ I-1933 NMe₂ H H H H H OMe OMe COOH H H H OMs O —CH₂CH═CCl₂ I-1934 NMe₂ H H H H H OMe OMe COOH H H H OMs O —CH₂C≡CMe I-1935 NMe₂ H H H H H OMe OMe COOH H H H OMs O —CH₂C₆H₄-4-Me

TABLE 297 I-1936 NMe₂ H H H H H OMe OMe COOH H H H COOH O —CH₂CH═CMe₂ I-1937 NMe₂ H H H H H OMe OMe COOH H H H COOH O —(CH₂)₂CH═CMe₂ I-1938 NMe₂ H H H H H OMe OMe COOH H H H COOH O —CH₂CH═CCl₂ I-199 NMe₂ H H H H H OMe OMe COOH H H H COOH O —CH₂C≡CMe I-190 NMe₂ H H H H H OMe OMe COOH H H H COOH O —CH₂C₆H₄-4-Me I-1941 NMe₂ H H H H H OMe OMe COOH H H H CH₂OH O —CH₂CH═CMe₂ I-1942 NMe₂ H H H H H OMe OMe COOH H H H CH₂OH O —(CH₂)₂CH═CMe₂ I-1943 NMe₂ H H H H H OMe OMe COOH H H H CH₂OH O —CH₂CH═CCl₂ I-1944 NMe₂ H H H H H OMe OMe COOH H H H CH₂OH O —CH₂C≡CMe I-1945 NMe₂ H H H H H OMe OMe COOH H H H CH₂OH O —CH₂C₆H₄-4-Me I-1946 NMe₂ H H H H H OMe OMe COOH H H H F O —CH₂CH═CMe₂ I-1947 NMe₂ H H H H H OMe OMe COOH H H H F O —(CH₂)₂CH═CMe₂ I-1948 NMe₂ H H H H H OMe OMe COOH H H H F O —CH₂CH═CCl₂ I-1949 NMe₂ H H H H H OMe OMe COOH H H H F O —CH₂C≡CMe I-1950 NMe₂ H H H H H OMe OMe COOH H H H F O —CH₂C₆H₄-4-Me I-1951 NMe₂ H H H H H OMe OMe CH₂OH H H H OH O —CH₂CH═CMe₂ I-1952 NMe₂ H H H H H OMe OMe CH₂OH H H H OH O —(CH₂)₂CH═CMe₂ I-1953 NMe₂ H H H H H OMe OMe CH₂OH H H H OH O —CH₂CH═CCl₂ I-1954 NMe₂ H H H H H OMe OMe CH₂OH H H H OH O —CH₂C≡CMe I-1955 NMe₂ H H H H H OMe OMe CH₂OH H H H OH O —CH₂C₆H₄-4-Me I-1956 NMe₂ H H H H H OMe OMe CH₂OH H H H OMs O —CH₂CH═CMe₂

TABLE 298 I-1957 NMe₂ H H H H H OMe OMe CH₂OH H H H OMs O —(CH₂)₂CH═CMe₂ I-1958 NMe₂ H H H H H OMe OMe CH₂OH H H H OMs O —CH₂CH═CCl₂ I-1959 NMe₂ H H H H H OMe OMe CH₂OH H H H OMs O —CH₂C≡CMe I-1960 NMe₂ H H H H H OMe OMe CH₂OH H H H OMs O —CH₂C₆H₄-4-Me I-1961 NMe₂ H H H H H OMe OMe CH₂OH H H H COOH O —CH₂CH═CMe₂ I-1962 NMe₂ H H H H H OMe OMe CH₂OH H H H COOH O —(CH₂)₂CH═CMe₂ I-1963 NMe₂ H H H H H OMe OMe CH₂OH H H H COOH O —CH₂CH═CCl₂ I-1964 NMe₂ H H H H H OMe OMe CH₂OH H H H COOH O —CH₂C≡CMe I-1965 NMe₂ H H H H H OMe OMe CH₂OH H H H COOH O —CH₂C₆H₄-4-Me I-1966 NMe₂ H H H H H OMe OMe CH₂OH H H H CH₂OH O —CH₂CH═CMe₂ I-1967 NMe₂ H H H H H OMe OMe CH₂OH H H H CH₂OH O —(CH₂)₂CH═CMe₂ I-198 NMe₂ H H H H H OMe OMe CH₂OH H H H CH₂OH O —CH₂CH═CCl₂ I-1969 NMe₂ H H H H H OMe OMe CH₂OH H H H CH₂OH O —CH₂C≡CMe I-1970 NMe₂ H H H H H OMe OMe CH₂OH H H H CH₂OH O —CH₂C₆H₄-4-Me I-1971 NMe₂ H H H H H OMe OMe CH₂OH H H H F O —CH₂CH═CMe₂ I-1972 NMe₂ H H H H H OMe OMe CH₂OH H H H F O —(CH₂)₂CH═CMe₂ I-1973 NMe₂ H H H H H OMe OMe CH₂OH H H H F O —CH₂CH═CCl₂ I-1974 NMe₂ H H H H H OMe OMe CH₂OH H H H F O —CH₂C≡CMe I-1975 NMe₂ H H H H H OMe OMe CH₂OH H H H F O —CH₂C₆H₄-4-Me I-1976 NMe₂ H H H H H OMe OMe Me H H H OH O —CH₂CH═CMe₂ I-1977 NMe₂ H H H H H OMe OMe Me H H H OH O —(CH₂)₂CH═CMe₂

TABLE 299 I-1978 NMe₂ H H H H H OMe OMe Me H H H OH O —CH₂CH═CCl₂ I-1979 NMe₂ H H H H H OMe OMe Me H H H OH O —CH₂C≡CMe I-1980 NMe₂ H H H H H OMe OMe Me H H H OH O —CH₂C₆H₄-4-Me I-1981 NMe₂ H H H H H OMe OMe Me H H H OMs O —CH₂CH═CMe₂ I-1982 NMe₂ H H H H H OMe OMe Me H H H OMs O —(CH₂)₂CH═CMe₂ I-1983 NMe₂ H H H H H OMe OMe Me H H H OMs O —CH₂CH═CCl₂ I-1984 NMe₂ H H H H H OMe OMe Me H H H OMs O —CH₂C≡CMe I-1985 NMe₂ H H H H H OMe OMe Me H H H OMs O —CH₂C₆H₄-4-Me I-1986 NMe₂ H H H H H OMe OMe Me H H H COOH O —CH₂CH═CMe₂ I-1987 NMe₂ H H H H H OMe OMe Me H H H COOH O —(CH₂)₂CH═CMe₂ I-1988 NMe₂ H H H H H OMe OMe Me H H H COOH O —CH₂CH═CCl₂ I-1989 NMe₂ H H H H H OMe OMe Me H H H COOH O —CH₂C≡CMe I-1990 NMe₂ H H H H H OMe OMe Me H H H COOH O —CH₂C₆H₄-4-Me I-1991 NMe₂ H H H H H OMe OMe Me H H H CH₂OH O —CH₂CH═CMe₂ I-1992 NMe₂ H H H H H OMe OMe Me H H H CH₂OH O —(CH₂)₂CH═CMe₂ I-1993 NMe₂ H H H H H OMe OMe Me H H H CH₂OH O —CH₂CH═CCl₂ I-1994 NMe₂ H H H H H OMe OMe Me H H H CH₂OH O —CH₂C≡CMe I-1995 NMe₂ H H H H H OMe OMe Me H H H CH₂OH O —CH₂C₆H₄-4-Me I-1996 NMe₂ H H H H H OMe OMe Me H H H F O —CH₂CH═CMe₂ I-1997 NMe₂ H H H H H OMe OMe Me H H H F O —(CH₂)₂CH═CMe₂ I-1998 NMe₂ H H H H H OMe OMe Me H H H F O —CH₂CH═CCl₂

TABLE 300 I-1999 NMe₂ H H H H H OMe OMe Me H H H F O —CH₂C≡CMe I-2000 NMe₂ H H H H H OMe OMe Me H H H F O —CH₂C₆H₄-4-Me I-2001 NMe₂ H H H H H OMe OMe H H H H OH O —CH₂CH═CMe₂ I-2002 NMe₂ H H H H H OMe OMe H H H H OH O —(CH₂)₂CH═CMe₂ I-2003 NMe₂ H H H H H OMe OMe H H H H OH O —CH₂CH═CCl₂ I-2004 NMe₂ H H H H H OMe OMe H H H H OH O —CH₂C≡CMe I-2005 NMe₂ H H H H H OMe OMe H H H H OH O —CH₂C₆H₄-4-Me I-2006 NMe₂ H H H H H OMe OMe H H H H OMs O —CH₂CH═CMe₂ I-2007 NMe₂ H H H H H OMe OMe H H H H OMs O —(CH₂)₂CH═CMe₂ I-2008 NMe₂ H H H H H OMe OMe H H H H OMs O —CH₂CH═CCl₂ I-2009 NMe₂ H H H H H OMe OMe H H H H OMs O —CH₂C≡CMe I-2010 NMe₂ H H H H H OMe OMe H H H H OMs O —CH₂C₆H₄-4-Me I-2011 NMe₂ H H H H H OMe OMe H H H H COOH O —CH₂CH═CMe₂ I-2012 NMe₂ H H H H H OMe OMe H H H H COOH O —(CH₂)₂CH═CMe₂ I-2013 NMe₂ H H H H H OMe OMe H H H H COOH O —CH₂CH═CCl₂ I-2014 NMe₂ H H H H H OMe OMe H H H H COOH O —CH₂C≡CMe I-2015 NMe₂ H H H H H OMe OMe H H H H COOH O —CH₂C₆H₄-4-Me I-2016 NMe₂ H H H H H OMe OMe H H H H CH₂OH O —CH₂CH═CMe₂ I-2017 NMe₂ H H H H H OMe OMe H H H H CH₂OH O —(CH₂)₂CH═CMe₂ I-2018 NMe₂ H H H H H OMe OMe H H H H CH₂OH O —CH₂CH═CCl₂ I-2019 NMe₂ H H H H H OMe OMe H H H H CH₂OH O —CH₂C≡CMe

TABLE 301 I-2020 NMe₂ H H H H H OMe OMe H H H H CH₂OH O —CH₂C₆H₄-4-Me I-2021 NMe₂ H H H H H OMe OMe H H H H F O —CH₂CH═CMe₂ I-2022 NMe₂ H H H H H OMe OMe H H H H F O —(CH₂)₂CH═CMe₂ I-2023 NMe₂ H H H H H OMe OMe H H H H F O —CH₂CH═CCl₂ I-2024 NMe₂ H H H H H OMe OMe H H H H F O —CH₂C≡CMe I-2025 NMe₂ H H H H H OMe OMe H H H H F O —CH₂C₆H₄-4-Me I-2026 NMe₂ H H H H F OMe OMe OH H H H OH O —CH₂CH═CMe₂ I-2027 NMe₂ H H H H F OMe OMe OH H H H OH O —(CH₂)₂CH═CMe₂ I-2028 NMe₂ H H H H F OMe OMe OH H H H OH O —CH₂CH═CCl₂ I-2029 NMe₂ H H H H F OMe OMe OH H H H OH O —CH₂C≡CMe I-2030 NMe₂ H H H H F OMe OMe OH H H H OH O —CH₂C₆H₄-4-Me I-2031 NMe₂ H H H H F OMe OMe OH H H H OMs O —CH₂CH═CMe₂ I-2032 NMe₂ H H H H F OMe OMe OH H H H OMs O —(CH₂)₂CH═CMe₂ I-2033 NMe₂ H H H H F OMe OMe OH H H H OMs O —CH₂CH═CCl₂ I-2034 NMe₂ H H H H F OMe OMe OH H H H OMs O —CH₂C≡CMe I-2035 NMe₂ H H H H F OMe OMe OH H H H OMs O —CH₂C₆H₄-4-Me I-2036 NMe₂ H H H H F OMe OMe OH H H H COOH O —CH₂CH═CMe₂ I-2037 NMe₂ H H H H F OMe OMe OH H H H COOH O —(CH₂)₂CH═CMe₂ I-2038 NMe₂ H H H H F OMe OMe OH H H H COOH O —CH₂CH═CCl₂ I-2039 NMe₂ H H H H F OMe OMe OH H H H COOH O —CH₂C≡CMe I-2040 NMe₂ H H H H F OMe OMe OH H H H COOH O —CH₂C₆H₄-4-Me

TABLE 302 I-2041 NMe₂ H H H H F OMe OMe OH H H H CH₂OH O —CH₂CH═CMe₂ I-2042 NMe₂ H H H H F OMe OMe OH H H H CH₂OH O —(CH₂)₂CH═CMe₂ I-2043 NMe₂ H H H H F OMe OMe OH H H H CH₂OH O —CH₂CH═CCl₂ I-2044 NMe₂ H H H H F OMe OMe OH H H H CH₂OH O —CH₂C≡CMe I-2045 NMe₂ H H H H F OMe OMe OH H H H CH₂OH O —CH₂C₆H₄-4-Me I-2046 NMe₂ H H H H F OMe OMe OH H H H F O —CH₂CH═CMe₂ I-2047 NMe₂ H H H H F OMe OMe OH H H H F O —(CH₂)₂CH═CMe₂ I-2048 NMe₂ H H H H F OMe OMe OH H H H F O —CH₂CH═CCl₂ I-2049 NMe₂ H H H H F OMe OMe OH H H H F O —CH₂C≡CMe I-2050 NMe₂ H H H H F OMe OMe OH H H H F O —CH₂C₆H₄-4-Me I-2051 COOH H H H H H OMe OMe OH H H H OH O —(CH₂)₂CH═CMe₂ I-2052 COOH H H H H H OMe OMe OH H H H OH O —CH₂CH═CCl₂ I-2053 COOH H H H H H OMe OMe OH H H H OH O —CH₂C≡CMe I-2054 COOH H H H H H OMe OMe OH H H H OMs O —CH₂CH═CMe₂ I-2055 COOH H H H H H OMe OMe OH H H H OMs O —(CH₂)₂CH═CMe₂ I-2056 COOH H H H H H OMe OMe OH H H H OMs O —CH₂CH═CCl₂ I-2057 COOH H H H H H OMe OMe OH H H H OMs O —CH₂C≡CMe I-2058 COOH H H H H H OMe OMe OH H H H OMs O —CH₂C₆H₄-4-Me I-2059 COOH H H H H H OMe OMe OH H H H COOH O —CH₂CH═CMe₂ I-2060 COOH H H H H H OMe OMe OH H H H COOH O —(CH₂)₂CH═CMe₂ I-2061 COOH H H H H H OMe OMe OH H H H COOH O —CH₂CH═CCl₂

TABLE 303 I-2062 COOH H H H H H OMe OMe OH H H H COOH O —CH₂C≡CMe I-2063 COOH H H H H H OMe OMe OH H H H COOH O —CH₂C₆H₄-4-Me I-2064 COOH H H H H H OMe OMe OH H H H CH₂OH O —CH₂CH═CMe₂ I-2065 COOH H H H H H OMe OMe OH H H H CH₂OH O —(CH₂)₂CH═CMe₂ I-2066 COOH H H H H H OMe OMe OH H H H CH₂OH O —CH₂CH═CCl₂ I-2067 COOH H H H H H OMe OMe OH H H H CH₂OH O —CH₂C≡CMe I-2068 COOH H H H H H OMe OMe OH H H H CH₂OH O —CH₂C₆H₄-4-Me I-2069 COOH H H H H H OMe OMe OH H H H F O —CH₂CH═CMe₂ I-2070 COOH H H H H H OMe OMe OH H H H F O —(CH₂)₂CH═CMe₂ I-2071 COOH H H H H H OMe OMe OH H H H F O —CH₂CH═CCl₂ I-2072 COOH H H H H H OMe OMe OH H H H F O —CH₂C≡CMe I-2073 COOH H H H H H OMe OMe OH H H H F O —CH₂C₆H₄-4-Me I-2074 COOH H H H H H OMe OMe COOH H H H OH O —CH₂CH═CMe₂ I-2075 COOH H H H H H OMe OMe COOH H H H OH O —(CH₂)₂CH═CMe₂ I-2076 COOH H H H H H OMe OMe COOH H H H OH O —CH₂CH═CCl₂ I-2077 COOH H H H H H OMe OMe COOH H H H OH O —CH₂C≡CMe I-2078 COOH H H H H H OMe OMe COOH H H H OH O —CH₂C₆H₄-4-Me I-2079 COOH H H H H H OMe OMe COOH H H H OMs O —CH₂CH═CMe₂ I-2080 COOH H H H H H OMe OMe COOH H H H OMs O —(CH₂)₂CH═CMe₂ I-2081 COOH H H H H H OMe OMe COOH H H H OMs O —CH₂CH═CCl₂ I-2082 COOH H H H H H OMe OMe COOH H H H OMs O —CH₂C≡CMe

TABLE 304 I-2083 COOH H H H H H OMe OMe COOH H H H OMs O —CH₂C₆H₄-4-Me I-2084 COOH H H H H H OMe OMe COOH H H H COOH O —CH₂CH═CMe₂ I-2085 COOH H H H H H OMe OMe COOH H H H COOH O —(CH₂)₂CH═CMe₂ I-2086 COOH H H H H H OMe OMe COOH H H H COOH O —CH₂CH═CCl₂ I-2087 COOH H H H H H OMe OMe COOH H H H COOH O —CH₂C≡CMe I-2088 COOH H H H H H OMe OMe COOH H H H COOH O —CH₂C₆H₄-4-Me I-2089 COOH H H H H H OMe OMe COOH H H H CH₂OH O —CH₂CH═CMe₂ I-2090 COOH H H H H H OMe OMe COOH H H H CH₂OH O —(CH₂)₂CH═CMe₂ I-2091 COOH H H H H H OMe OMe COOH H H H CH₂OH O —CH₂CH═CCl₂ I-2092 COOH H H H H H OMe OMe COOH H H H CH₂OH O —CH₂C≡CMe I-2093 COOH H H H H H OMe OMe COOH H H H CH₂OH O —CH₂C₆H₄-4-Me I-2094 COOH H H H H H OMe OMe COOH H H H F O —CH₂CH═CMe₂ I-2095 COOH H H H H H OMe OMe COOH H H H F O —(CH₂)₂CH═CMe₂ I-2096 COOH H H H H H OMe OMe COOH H H H F O —CH₂CH═CCl₂ I-2097 COOH H H H H H OMe OMe COOH H H H F O —CH₂C≡CMe I-2098 COOH H H H H H OMe OMe COOH H H H F O —CH₂C₆H₄-4-Me I-2099 COOH H H H H H OMe OMe CH₂OH H H H OH O —CH₂CH═CMe₂ I-2100 COOH H H H H H OMe OMe CH₂OH H H H OH O —(CH₂)₂CH═CMe₂ I-2101 COOH H H H H H OMe OMe CH₂OH H H H OH O —CH₂CH═CCl₂ I-2102 COOH H H H H H OMe OMe CH₂OH H H H OH O —CH₂C≡CMe I-2103 COOH H H H H H OMe OMe CH₂OH H H H OH O —CH₂C₆H₄-4-Me

TABLE 305 I-2104 COOH H H H H H OMe OMe CH₂OH H H H OMs O —CH₂CH═CMe₂ I-2105 COOH H H H H H OMe OMe CH₂OH H H H OMs O —(CH₂)₂CH═CMe₂ I-2106 COOH H H H H H OMe OMe CH₂OH H H H OMs O —CH₂CH═CCl₂ I-2107 COOH H H H H H OMe OMe CH₂OH H H H OMs O —CH₂C≡CMe I-2108 COOH H H H H H OMe OMe CH₂OH H H H OMs O —CH₂C₆H₄-4-Me I-2109 COOH H H H H H OMe OMe CH₂OH H H H COOH O —CH₂CH═CMe₂ I-2110 COOH H H H H H OMe OMe CH₂OH H H H COOH O —(CH₂)₂CH═CMe₂ I-2111 COOH H H H H H OMe OMe CH₂OH H H H COOH O —CH₂CH═CCl₂ I-2112 COOH H H H H H OMe OMe CH₂OH H H H COOH O —CH₂C≡CMe I-2113 COOH H H H H H OMe OMe CH₂OH H H H COOH O —CH₂C₆H₄-4-Me I-2114 COOH H H H H H OMe OMe CH₂OH H H H CH₂OH O —CH₂CH═CMe₂ I-2115 COOH H H H H H OMe OMe CH₂OH H H H CH₂OH O —(CH₂)₂CH═CMe₂ I-2116 COOH H H H H H OMe OMe CH₂OH H H H CH₂OH O —CH₂CH═CCl₂ I-2117 COOH H H H H H OMe OMe CH₂OH H H H CH₂OH O —CH₂C≡CMe I-2118 COOH H H H H H OMe OMe CH₂OH H H H CH₂OH O —CH₂C₆H₄-4-Me I-2119 COOH H H H H H OMe OMe CH₂OH H H H F O —CH₂CH═CMe₂ I-2120 COOH H H H H H OMe OMe CH₂OH H H H F O —(CH₂)₂CH═CMe₂ I-2121 COOH H H H H H OMe OMe CH₂OH H H H F O —CH₂CH═CCl₂ I-2122 COOH H H H H H OMe OMe CH₂OH H H H F O —CH₂C≡CMe I-2123 COOH H H H H H OMe OMe CH₂OH H H H F O —CH₂C₆H₄-4-Me I-2124 COOH H H H H H OMe OMe Me H H H OH O —CH₂CH═CMe₂

TABLE 306 I-2125 COOH H H H H H OMe OMe Me H H H OH O —(CH₂)₂CH═CMe₂ I-2126 COOH H H H H H OMe OMe Me H H H OH O —CH₂CH═CCl₂ I-2127 COOH H H H H H OMe OMe Me H H H OH O —CH₂C≡CMe I-2128 COOH H H H H H OMe OMe Me H H H OH O —CH₂C₆H₄-4-Me I-2129 COOH H H H H H OMe OMe Me H H H OMs O —CH₂CH═CMe₂ I-2130 COOH H H H H H OMe OMe Me H H H OMs O —(CH₂)₂CH═CMe₂ I-2131 COOH H H H H H OMe OMe Me H H H OMs O —CH₂CH═CCl₂ I-2132 COOH H H H H H OMe OMe Me H H H OMs O —CH₂C≡CMe I-2133 COOH H H H H H OMe OMe Me H H H OMs O —CH₂C₆H₄-4-Me I-2134 COOH H H H H H OMe OMe Me H H H COOH O —CH₂CH═CMe₂ I-2135 COOH H H H H H OMe OMe Me H H H COOH O —(CH₂)₂CH═CMe₂ I-2136 COOH H H H H H OMe OMe Me H H H COOH O —CH₂CH═CCl₂ I-2137 COOH H H H H H OMe OMe Me H H H COOH O —CH₂C≡CMe I-2138 COOH H H H H H OMe OMe Me H H H COOH O —CH₂C₆H₄-4-Me I-2139 COOH H H H H H OMe OMe Me H H H CH₂OH O —CH₂CH═CMe₂ I-2140 COOH H H H H H OMe OMe Me H H H CH₂OH O —(CH₂)₂CH═CMe₂ I-2141 COOH H H H H H OMe OMe Me H H H CH₂OH O —CH₂CH═CCl₂ I-2142 COOH H H H H H OMe OMe Me H H H CH₂OH O —CH₂C≡CMe I-2143 COOH H H H H H OMe OMe Me H H H CH₂OH O —CH₂C₆H₄-4-Me I-2144 COOH H H H H H OMe OMe Me H H H F O —CH₂CH═CMe₂ I-2145 COOH H H H H H OMe OMe Me H H H F O —(CH₂)₂CH═CMe₂

TABLE 307 I-2146 COOH H H H H H OMe OMe Me H H H F O —CH₂CH═CCl₂ I-2147 COOH H H H H H OMe OMe Me H H H F O —CH₂C≡CMe I-2148 COOH H H H H H OMe OMe Me H H H F O —CH₂C₆H₄-4-Me I-2149 COOH H H H H H OMe OMe H H H H OH O —CH₂CH═CMe₂ I-2150 COOH H H H H H OMe OMe H H H H OH O —(CH₂)₂CH═CMe₂ I-2151 COOH H H H H H OMe OMe H H H H OH O —CH₂CH═CCl₂ I-2152 COOH H H H H H OMe OMe H H H H OH O —CH₂C≡CMe I-2153 COOH H H H H H OMe OMe H H H H OH O —CH₂C₆H₄-4-Me I-2154 COOH H H H H H OMe OMe H H H H OMs O —CH₂CH═CMe₂ I-2155 COOH H H H H H OMe OMe H H H H OMs O —(CH₂)₂CH═CMe₂ I-2156 COOH H H H H H OMe OMe H H H H OMs O —CH₂CH═CCl₂ I-2157 COOH H H H H H OMe OMe H H H H OMs O —CH₂C≡CMe I-2158 COOH H H H H H OMe OMe H H H H OMs O —CH₂C₆H₄-4-Me I-2159 COOH H H H H H OMe OMe H H H H COOH O —CH₂CH═CMe₂ I-2160 COOH H H H H H OMe OMe H H H H COOH O —(CH₂)₂CH═CMe₂ I-2161 COOH H H H H H OMe OMe H H H H COOH O —CH₂CH═CCl₂ I-2162 COOH H H H H H OMe OMe H H H H COOH O —CH₂C≡CMe I-2163 COOH H H H H H OMe OMe H H H H COOH O —CH₂C₆H₄-4-Me I-2164 COOH H H H H H OMe OMe H H H H CH₂OH O —CH₂CH═CMe₂ I-2165 COOH H H H H H OMe OMe H H H H CH₂OH O —(CH₂)₂CH═CMe₂ I-2166 COOH H H H H H OMe OMe H H H H CH₂OH O —CH₂CH═CCl₂

TABLE 308 I-2167 COOH H H H H H OMe OMe H H H H CH₂OH O —CH₂C≡CMe I-2168 COOH H H H H H OMe OMe H H H H CH₂OH O —CH₂C₆H₄-4-Me I-2169 COOH H H H H H OMe OMe H H H H F O —CH₂CH≡CMe₂ I-2170 COOH H H H H H OMe OMe H H H H F O —(CH₂)₂CH≡CMe₂ I-2171 COOH H H H H H OMe OMe H H H H F O —CH₂CH═CCl₂ I-2172 COOH H H H H H OMe OMe H H H H F O —CH₂C≡CMe I-2173 COOH H H H H H OMe OMe H H H H F O —CH₂C₆H₄-4-Me I-2174 COOH H H H H F OMe OMe OH H H H OH O —CH₂CH═CMe₂ I-2175 COOH H H H H F OMe OMe OH H H H OH O —(CH₂)₂CH═CMe₂ I-2176 COOH H H H H F OMe OMe OH H H H OH O —CH₂CH═CCl₂ I-2177 COOH H H H H F OMe OMe OH H H H OH O —CH₂C≡CMe I-2178 COOH H H H H F OMe OMe OH H H H OH O —CH₂C₆H₄-4-Me I-2179 COOH H H H H F OMe OMe OH H H H OMs O —CH₂CH═CMe₂ I-2180 COOH H H H H F OMe OMe OH H H H OMs O —(CH₂)₂CH═CMe₂ I-2181 COOH H H H H F OMe OMe OH H H H OMs O —CH₂CH═CCl₂ I-2182 COOH H H H H F OMe OMe OH H H H OMs O —CH₂C≡CMe I-2183 COOH H H H H F OMe OMe OH H H H OMs O —CH₂C₆H₄-4-Me I-2184 COOH H H H H F OMe OMe OH H H H COOH O —CH₂CH═CMe₂ I-2185 COOH H H H H F OMe OMe OH H H H COOH O —(CH₂)₂CH═CMe₂ I-2186 COOH H H H H F OMe OMe OH H H H COOH O —CH₂CH═CCl₂ I-2187 COOH H H H H F OMe OMe OH H H H COOH O —CH₂C≡CMe

TABLE 309 I-2188 COOH H H H H F OMe OMe OH H H H COOH O —CH₂C₆H₄-4-Me I-2189 COOH H H H H F OMe OMe OH H H H CH₂OH O —CH₂CH═CMe₂ I-2190 COOH H H H H F OMe OMe OH H H H CH₂OH O —(CH₂)₂CH═CMe₂ I-2191 COOH H H H H F OMe OMe OH H H H CH₂OH O —CH₂CH═CCl₂ I-2192 COOH H H H H F OMe OMe OH H H H CH₂OH O —CH₂C≡CMe I-2193 COOH H H H H F OMe OMe OH H H H CH₂OH O —CH₂C₆H₄-4-Me I-2194 COOH H H H H F OMe OMe OH H H H F O —CH₂CH═CMe₂ I-2195 COOH H H H H F OMe OMe OH H H H F O —(CH₂)₂CH═CMe₂ I-2196 COOH H H H H F OMe OMe OH H H H F O —CH₂CH═CCl₂ I-2197 COOH H H H H F OMe OMe OH H H H F O —CH₂C≡CMe I-2198 COOH H H H H F OMe OMe OH H H H F O —CH₂C₆H₄-4-Me I-2199 NO₂ H H H H H OMe OMe H H H H OMs O —(CH₂)₂CH═CMe₂ I-2200 OMs NO₂ H H H H OMe OMe H H H H OMs O —(CH₂)₂CH═CMe₂ I-2201 OMs H H H H H OMe OMe H NO₂ H H OMs O —(CH₂)₂CH═CMe₂ I-2202 CN H H H H H OMe OMe H H H H OMs O —(CH₂)₂CH═CMe₂ I-2203 OMs CN H H H H OMe OMe H H H H OMs O —(CH₂)₂CH═CMe₂ I-2204 OH H H H H H OMe OMe OMs H H H OH O —CH₂CH═CMe₂ I-2205 OH H H H H H OMe OMe OMs H H H OH O —CH₂C₆H₅ I-2206 OH H H H H H OMe OMe OMs H H H NH₂ O —CH₂CH═CMe₂ I-2207 OH H H H H H OMe OMe OMs H H H NH₂ O —CH₂C₆H₅ I-2208 OH H H H H H OMe OEt OH H H H OH O —CH₂C₆H₅

TABLE 310 I-2209 OH H H H H H OMe OEt OH H H H NH₂ O —CH₂CH═CMe₂ I-2210 OH H H H H H Me Me H H H H OH O —CH₂C₆H₅ I-2211 OH H H H H H Me Me H H H H NH₂ O —CH₂CH═CMe₂ I-2212 OH H H H H H Me Me H H H H NH₂ O —CH₂C₆H₅ I-2213 OH H H H H H OMe OMe NH₂ H H H OH O —CH₂CH═CMe₂ I-2214 OH H H H H H OMe OMe NH₂ H H H NH₂ O —CH₂CH═CMe₂ I-2215 OH H H H H H OMe OMe NH₂ H H H NH₂ O —CH₂C₆H₅ I-2216 OH H H H H H OMe OMe OH H H H OH O —CH₂CH═CMe₂ I-2217 OH H H H H H OMe OMe OH H H H OH O —CH₂C₆H₅ I-2218 OH H H H H H OMe OMe OH H H H NH₂ O —CH₂CH═CMe₂ I-2219 OH H H H H H OMe OMe OH H H H NH₂ O —CH₂C₆H₅ I-2220 OMs H H H H H OMe OMe OMs H H H OH O —CH₂CH═CMe₂ I-2221 OMs H H H H H OMe OMe OMs H H H OH O —CH₂C₆H₅ I-2222 OMs H H H H H OMe OMe OMs H H H NH₂ O —CH₂CH═CMe₂ I-2223 OMs H H H H H OMe OMe OMs H H H NH₂ O —CH₂C₆H₅ I-2224 OMs H H H H H OMe OEt OH H H H OH O —CH₂CH═CMe₂ I-2225 OMs H H H H H OMe OEt OH H H H OH O —CH₂C₆H₅ I-2226 OMs H H H H H OMe OEt OH H H H NH₂ O —CH₂CH═CMe₂ I-2227 OMs H H H H H OMe OEt OH H H H NH₂ O —CH₂C₆H₅ I-2228 OMs H H H H H Me Me H H H H OH O —CH₂CH═CMe₂ I-2229 OMs H H H H H Me Me H H H H OH O —CH₂C₆H₅

TABLE 311 I-2230 OMs H H H H H Me Me H H H H NH₂ O —CH₂CH═CMe₂ I-2231 OMs H H H H H Me Me H H H H NH₂ O —CH₂C₆H₅ I-2232 OMs H H H H H OMe OMe NH₂ H H H OH O —CH₂CH═CMe₂ I-2233 OMs H H H H H OMe OMe NH₂ H H H NH₂ O —CH₂CH═CMe₂ I-2234 OMs H H H H H OMe OMe NH₂ H H H NH₂ O —CH₂C₆H₅ I-2235 OMs H H H H H OMe OMe OH H H H OH O —CH₂CH═CMe₂ I-2236 OMs H H H H H OMe OMe OH H H H OH O —CH₂C₆H₅ I-2237 OMs H H H H H OMe OMe OH H H H NH₂ O —CH₂CH═CMe₂ I-2238 OMs H H H H H OMe OMe OH H H H NH₂ O —CH₂C₆H₅ I-2239 CF₃ H H H H H OMe OMe OMs H H H OH O —CH₂CH═CMe₂ I-2240 CF₃ H H H H H OMe OMe OMs H H H OH O —CH₂C₆H₅ I-2241 CF₃ H H H H H OMe OMe OMs H H H NH₂ O —CH₂CH═CMe₂ I-2242 CF₃ H H H H H OMe OMe OMs H H H NH₂ O —CH₂C₆H₅ I-2243 CF₃ H H H H H OMe OEt OH H H H OH O —CH₂CH═CMe₂ I-2244 CF₃ H H H H H OMe OEt OH H H H OH O —CH₂C₆H₅ I-2245 CF₃ H H H H H OMe OEt OH H H H NH₂ O —CH₂CH═CMe₂ I-2246 CF₃ H H H H H OMe OEt OH H H H NH₂ O —CH₂C₆H₅ I-2247 CF₃ H H H H H Me Me H H H H OH O —CH₂CH═CMe₂ I-2248 CF₃ H H H H H Me Me H H H H OH O —CH₂C₆H₅ I-2249 CF₃ H H H H H Me Me H H H H NH₂ O —CH₂CH═CMe₂ I-2250 CF₃ H H H H H Me Me H H H H NH₂ O —CH₂C₆H₅

TABLE 312 I-2251 CF₃ H H H H H OMe OMe NH₂ H H H OH O —CH₂CH═CMe₂ I-2252 CF₃ H H H H H OMe OMe NH₂ H H H OH O —CH₂C₆H₅ I-2253 CF₃ H H H H H OMe OMe NH₂ H H H NH₂ O —CH₂CH═CMe₂ I-2254 CF₃ H H H H H OMe OMe NH₂ H H H NH₂ O —CH₂C₆H₅ I-2255 CF₃ H H H H H OMe OMe OH H H H OH O —CH₂CH═CMe₂ I-2256 CF₃ H H H H H OMe OMe OH H H H OH O —CH₂C₆H₅ I-2257 CF₃ H H H H H OMe OMe OH H H H NH₂ O —CH₂CH═CMe₂ I-2258 CF₃ H H H H H OMe OMe OH H H H NH₂ O —CH₂C₆H₅ I-2259 NH₂ H H H H H OMe OMe OMs H H H OH O —CH₂CH═CMe₂ I-2260 NH₂ H H H H H OMe OMe OMs H H H OH O —CH₂C₆H₅ I-2261 NH₂ H H H H H OMe OMe OMs H H H NH₂ O —CH₂CH═CMe₂ I-2262 NH₂ H H H H H OMe OMe OMs H H H NH₂ O —CH₂C₆H₅ I-2263 NH₂ H H H H H OMe OEt OH H H H OH O —CH₂CH═CMe₂ I-2264 NH₂ H H H H H OMe OEt OH H H H OH O —CH₂C₆H₅ I-2265 NH₂ H H H H H OMe OEt OH H H H NH₂ O —CH₂CH═CMe₂ I-2266 NH₂ H H H H H OMe OEt OH H H H NH₂ O —CH₂C₆H₅ I-2267 NH₂ H H H H H Me Me H H H H OH O —CH₂CH═CMe₂ I-2268 NH₂ H H H H H Me Me H H H H OH O —CH₂C₆H₅ I-2269 NH₂ H H H H H Me Me H H H H NH₂ O —CH₂CH═CMe₂ I-2270 NH₂ H H H H H Me Me H H H H NH₂ O —CH₂C₆H₅ I-2271 NH₂ H H H H H OMe OMe NH₂ H H H OH O —CH₂CH═CMe₂

TABLE 313 I-2272 NH₂ H H H H H OMe OMe NH₂ H H H OH O —CH₂C₆H₅ I-2273 NH₂ H H H H H OMe OMe NH₂ H H H NH₂ O —CH₂CH═CMe₂ I-2274 NH₂ H H H H H OMe OMe NH₂ H H H NH₂ O —CH₂C₆H₅ I-2275 NH₂ H H H H H OMe OMe OH H H H OH O —CH₂CH═CMe₂ I-2276 NH₂ H H H H H OMe OMe OH H H H OH O —CH₂C₆H₅ I-2277 NH₂ H H H H H OMe OMe OH H H H NH₂ O —CH₂CH═CMe₂ I-2278 NH₂ H H H H H OMe OMe OH H H H NH₂ O —CH₂C₆H₅ I-2279 —NHCH₂CH═CMe₂ H F H H Me Me Me H H H H OMe NH —CH₂CH═CMe₂ I-2280 —NHCH₂CH═CMe₂ H F H H Me Me Me H H H H OMe NH —(CH₂)₂CHMe₂ I-2281 —NHCH₂CH═CMe₂ H F H H Me Me Me H H H H OMe NMe Me I-2282 —NHCH₂CH═CMe₂ H F H H Me Me Me H H H H OMe O —CH₂CH═CMe₂ I-2283 —NHCH₂CH═CMe₂ H F H H Me Me Me H H H H OMe O —CH₂CH═CCl₂ I-2284 —NHCH₂CH═CMe₂ H F H H Me Me Me H H H F H NH —CH₂CH═CMe₂ I-2285 —NHCH₂CH═CMe₂ H F H H Me Me Me H H H F H NH —(CH₂)₂CHMe₂ I-2286 —NHCH₂CH═CMe₂ H F H H Me Me Me H H H F H NMe Me I-2287 —NHCH₂CH═CMe₂ H F H H Me Me Me H H H F H O —CH₂CH═CMe₂ I-2288 —NHCH₂CH═CMe₂ H F H H Me Me Me H H H F H O —CH₂CH═CCl₂ I-2289 —NHCH₂CH═CMe₂ H F H H Me Me Me H H H H OEt NH —CH₂CH═CMe₂ I-2290 —NHCH₂CH═CMe₂ H F H H Me Me Me H H H H OEt NH —(CH₂)₂CHMe₂ I-2291 —NHCH₂CH═CMe₂ H F H H Me Me Me H H H H OEt NMe Me I-2292 —NHCH₂CH═CMe₂ H F H H Me Me Me H H H H OEt O —CH₂CH═CMe₂

TABLE 314 I-2293 —NHCH₂CH═CMe₂ H F H H Me Me Me H H H H OEt O —CH₂CH═CCl₂ I-2294 —NHCH₂CH═CMe₂ H F H H H Me OMe OH H H H OMe NH —CH₂CH═CMe₂ I-2295 —NHCH₂CH═CMe₂ H F H H H Me OMe OH H H H OMe NH —(CH₂)₂CHMe₂ I-2296 —NHCH₂CH═CMe₂ H F H H H Me OMe OH H H H OMe NMe Me I-2297 —NHCH₂CH═CMe₂ H F H H H Me OMe OH H H H OMe O —CH₂CH═CMe₂ I-2298 —NHCH₂CH═CMe₂ H F H H H Me OMe OH H H H OMe O —CH₂CH═CCl₂ I-2299 —NHCH₂CH═CMe₂ H F H H H Me OMe OH H H F H NH —CH₂CH═CMe₂ I-2300 —NHCH₂CH═CMe₂ H F H H H Me OMe OH H H F H NH —(CH₂)₂CHMe₂ I-2301 —NHCH₂CH═CMe₂ H F H H H Me OMe OH H H F H NMe Me I-2302 —NHCH₂CH═CMe₂ H F H H H Me OMe OH H H F H O —CH₂CH═CMe₂ I-2303 —NHCH₂CH═CMe₂ H F H H H Me OMe OH H H F H O —CH₂CH═CCl₂ I-2304 —NHCH₂CH═CMe₂ H F H H H Me OMe OH H H H OEt NH —CH₂CH═CMe₂ I-2305 —NHCH₂CH═CMe₂ H F H H H Me OMe OH H H H OEt NH —(CH₂)₂CHMe₂ I-2306 —NHCH₂CH═CMe₂ H F H H H Me OMe OH H H H OEt NMe Me I-2307 —NHCH₂CH═CMe₂ H F H H H Me OMe OH H H H OEt O —CH₂CH═CMe₂ I-2308 —NHCH₂CH═CMe₂ H F H H H Me OMe OH H H H OEt O —CH₂CH═CCl₂ I-2309 —NHCH₂CH═CMe₂ H F H H Me H Me OH H H H OMe NH —CH₂CH═CMe₂ I-2330 —NHCH₂CH═CMe₂ H F H H Me H Me OH H H H OMe NH —(CH₂)₂CHMe₂ I-2331 —NHCH₂CH═CMe₂ H F H H Me H Me OH H H H OMe NMe Me I-2332 —NHCH₂CH═CMe₂ H F H H Me H Me OH H H H OMe O —CH₂CH═CMe₂ I-2333 —NHCH₂CH═CMe₂ H F H H Me H Me OH H H H OMe O —CH₂CH═CCl₂

TABLE 315 I-2334 —NHCH₂CH═CMe₂ H F H H Me H Me OH H H F H NH —CH₂CH═CMe₂ I-2335 —NHCH₂CH═CMe₂ H F H H Me H Me OH H H F H NH —(CH₂)₂CHMe₂ I-2336 —NHCH₂CH═CMe₂ H F H H Me H Me OH H H F H NMe Me I-2337 —NHCH₂CH═CMe₂ H F H H Me H Me OH H H F H O —CH₂CH═CMe₂ I-2338 —NHCH₂CH═CMe₂ H F H H Me H Me OH H H F H O —CH₂CH═CCl₂ I-2339 —NHCH₂CH═CMe₂ H F H H Me H Me OH H H H OEt NH —CH₂CH═CMe₂ I-2340 —NHCH₂CH═CMe₂ H F H H Me H Me OH H H H OEt NH —(CH₂)₂CHMe₂ I-2341 —NHCH₂CH═CMe₂ H F H H Me H Me OH H H H OEt NMe Me I-2342 —NHCH₂CH═CMe₂ H F H H Me H Me OH H H H OEt O —CH₂CH═CMe₂ I-2343 —NHCH₂CH═CMe₂ H F H H Me H Me OH H H H OEt O —CH₂CH═CCl₂ I-2344 —NHCH₂CH═CMe₂ H F H H H Me Me Me H H H OMe NH —CH₂CH═CMe₂ I-2345 —NHCH₂CH═CMe₂ H F H H H Me Me Me H H H OMe NH —(CH₂)₂CHMe₂ I-2346 —NHCH₂CH═CMe₂ H F H H H Me Me Me H H H OMe NMe Me I-2347 —NHCH₂CH═CMe₂ H F H H H Me Me Me H H H OMe O —CH₂CH═CMe₂ I-2348 —NHCH₂CH═CMe₂ H F H H H Me Me Me H H H OMe O —CH₂CH═CCl₂ I-2349 —NHCH₂CH═CMe₂ H F H H H Me Me Me H H F H NH —CH₂CH═CMe₂ I-2350 —NHCH₂CH═CMe₂ H F H H H Me Me Me H H F H NH —(CH₂)₂CHMe₂ I-2351 —NHCH₂CH═CMe₂ H F H H H Me Me Me H H F H NMe Me I-2352 —NHCH₂CH═CMe₂ H F H H H Me Me Me H H F H O —CH₂CH═CMe₂ I-2353 —NHCH₂CH═CMe₂ H F H H H Me Me Me H H F H O —CH₂CH═CCl₂ I-2354 —NHCH₂CH═CMe₂ H F H H H Me Me Me H H H OEt NH —CH₂CH═CMe₂

TABLE 316 I-2355 —NHCH₂CH═CMe₂ H F H H H Me Me Me H H H OEt NH —(CH₂)₂CHMe₂ I-2356 —NHCH₂CH═CMe₂ H F H H H Me Me Me H H H OEt NMe Me I-2357 —NHCH₂CH═CMe₂ H F H H H Me Me Me H H H OEt O —CH₂CH═CMe₂ I-2358 —NHCH₂CH═CMe₂ H F H H H Me Me Me H H H OEt O —CH₂CH═CCl₂ I-2359 —NHCH₂CH═CMe₂ H F H H H OMe OEt OH H H H OMe NH —CH₂CH═CMe₂ I-2360 —NHCH₂CH═CMe₂ H F H H H OMe OEt OH H H H OMe NH —(CH₂)₂CHMe₂ I-2361 —NHCH₂CH═CMe₂ H F H H H OMe OEt OH H H H OMe NMe Me I-2362 —NHCH₂CH═CMe₂ H F H H H OMe OEt OH H H H OMe O —CH₂CH═CMe₂ I-2363 —NHCH₂CH═CMe₂ H F H H H OMe OEt OH H H H OMe O —CH₂CH═CCl₂ I-2364 —NHCH₂CH═CMe₂ H F H H H OMe OEt OH H H F H NH —CH₂CH═CMe₂ I-2365 —NHCH₂CH═CMe₂ H F H H H OMe OEt OH H H F H NH —(CH₂)₂CHMe₂ I-2366 —NHCH₂CH═CMe₂ H F H H H OMe OEt OH H H F H NMe Me I-2367 —NHCH₂CH═CMe₂ H F H H H OMe OEt OH H H F H O —CH₂CH═CMe₂ I-2368 —NHCH₂CH═CMe₂ H F H H H OMe OEt OH H H F H O —CH₂CH═CCl₂ I-2369 —NHCH₂CH═CMe₂ H F H H H OMe OEt OH H H H OEt NH —CH₂CH═CMe₂ I-2370 —NHCH₂CH═CMe₂ H F H H H OMe OEt OH H H H OEt NH —(CH₂)₂CHMe₂ I-2371 —NHCH₂CH═CMe₂ H F H H H OMe OEt OH H H H OEt NMe Me I-2372 —NHCH₂CH═CMe₂ H F H H H OMe OEt OH H H H OEt O —CH₂CH═CMe₂ I-2373 —NHCH₂CH═CMe₂ H F H H H OMe OEt OH H H H OEt O —CH₂CH═CCl₂ I-2374 —NH₂ H F H H Me Me Me H H H H OMe NH —CH₂CH═CMe₂ I-2375 —NH₂ H F H H Me Me Me H H H H OMe NH —(CH₂)₂CHMe₂

TABLE 317 I-2376 —NH₂ H F H H Me Me Me H H H H OMe NMe Me I-2377 —NH₂ H F H H Me Me Me H H H H OMe O —CH₂CH═CMe₂ I-2378 —NH₂ H F H H Me Me Me H H H H OMe O —CH₂CH═CCl₂ I-2379 —NH₂ H F H H Me Me Me H H H F H NH —CH₂CH═CMe₂ I-230 —NH₂ H F H H Me Me Me H H H F H NH —(CH₂)₂CHMe₂ I-2381 —NH₂ H F H H Me Me Me H H H F H NMe Me I-2382 —NH₂ H F H H Me Me Me H H H F H O —CH₂CH═CMe₂ I-2383 —NH₂ H F H H Me Me Me H H H F H O —CH₂CH═CCl₂ I-2384 —NH₂ H F H H Me Me Me H H H H OEt NH —CH₂CH═CMe₂ I-2385 —NH₂ H F H H Me Me Me H H H H OEt NH —(CH₂)₂CHMe₂ I-2386 —NH₂ H F H H Me Me Me H H H H OEt NMe Me I-2387 —NH₂ H F H H Me Me Me H H H H OEt O —CH₂CH═CMe₂ I-2388 —NH₂ H F H H Me Me Me H H H H OEt O —CH₂CH═CCl₂ I-2389 —NH₂ H F H H H Me OMe OH H H H OMe NH —CH₂CH═CMe₂ I-2390 —NH₂ H F H H H Me OMe OH H H H OMe NH —(CH₂)₂CHMe₂ I-2391 —NH₂ H F H H H Me OMe OH H H H OMe NMe Me I-2392 —NH₂ H F H H H Me OMe OH H H H OMe O —CH₂CH═CMe₂ I-2393 —NH₂ H F H H H Me OMe OH H H H OMe O —CH₂CH═CCl₂ I-2394 —NH₂ H F H H H Me OMe OH H H F H NH —CH₂CH═CMe₂ I-2395 —NH₂ H F H H H Me OMe OH H H F H NH —(CH₂)₂CHMe₂ I-2396 —NH₂ H F H H H Me OMe OH H H F H NMe Me

TABLE 318 I-2397 —NH₂ H F H H H Me OMe OH H H F H O —CH₂CH═CMe₂ I-2398 —NH₂ H F H H H Me OMe OH H H F H O —CH₂CH═CCl₂ I-2399 —NH₂ H F H H H Me OMe OH H H H OEt NH —CH₂CH═CMe₂ I-2400 —NH₂ H F H H H Me OMe OH H H H OEt NH —(CH₂)₂CHMe₂ I-2301 —NH₂ H F H H H Me OMe OH H H H OEt NMe Me I-2302 —NH₂ H F H H H Me OMe OH H H H OEt O —CH₂CH═CMe₂ I-2303 —NH₂ H F H H H Me OMe OH H H H OEt O —CH₂CH═CCl₂ I-2304 —NH₂ H F H H Me H Me OH H H H OMe NH —CH₂CH═CMe₂ I-2305 —NH₂ H F H H Me H Me OH H H H OMe NH —(CH₂)₂CHMe₂ I-2306 —NH₂ H F H H Me H Me OH H H H OMe NMe Me I-237 —NH₂ H F H H Me H Me OH H H H OMe O —CH₂CH═CMe₂ I-2308 —NH₂ H F H H Me H Me OH H H H OMe O —CH₂CH═CCl₂ I-2309 —NH₂ H F H H Me H Me OH H H F H NH —CH₂CH═CMe₂ I-2310 —NH₂ H F H H Me H Me OH H H F H NH —(CH₂)₂CHMe₂ I-2311 —NH₂ H F H H Me H Me OH H H F H NMe Me I-2312 —NH₂ H F H H Me H Me OH H H F H O —CH₂CH═CMe₂ I-2313 —NH₂ H F H H Me H Me OH H H F H O —CH₂CH═CCl₂ I-2314 —NH₂ H F H H Me H Me OH H H H OEt NH —CH₂CH═CMe₂ I-2315 —NH₂ H F H H Me H Me OH H H H OEt NH —(CH₂)₂CHMe₂ I-236 —NH₂ H F H H Me H Me OH H H H OEt NMe Me I-237 —NH₂ H F H H Me H Me OH H H H OEt O —CH₂CH═CMe₂

TABLE 319 I-2318 —NH₂ H F H H Me H Me OH H H H OEt O —CH₂CH═CCl₂ I-2319 —NH₂ H F H H H Me Me Me H H H OMe NH —CH₂CH═CMe₂ I-230 —NH₂ H F H H H Me Me Me H H H OMe NH —(CH₂)₂CHMe₂ I-2321 —NH₂ H F H H H Me Me Me H H H OMe NMe Me I-2322 —NH₂ H F H H H Me Me Me H H H OMe O —CH₂CH═CMe₂ I-2323 —NH₂ H F H H H Me Me Me H H H OMe O —CH₂CH═CCl₂ I-2324 —NH₂ H F H H H Me Me Me H H F H NH —CH₂CH═CMe₂ I-2325 —NH₂ H F H H H Me Me Me H H F H NH —(CH₂)₂CHMe₂ I-236 —NH₂ H F H H H Me Me Me H H F H NMe Me I-2327 —NH₂ H F H H H Me Me Me H H F H O —CH₂CH═CMe₂ I-2328 —NH₂ H F H H H Me Me Me H H F H O —CH₂CH═CCl₂ I-2329 —NH₂ H F H H H Me Me Me H H H OEt NH —CH₂CH═CMe₂ I-2330 —NH₂ H F H H H Me Me Me H H H OEt NH —(CH₂)₂CHMe₂ I-2331 —NH₂ H F H H H Me Me Me H H H OEt NMe Me I-2332 —NH₂ H F H H H Me Me Me H H H OEt O —CH₂CH═CMe₂ I-2333 —NH₂ H F H H H Me Me Me H H H OEt O —CH₂CH═CCl₂ I-2334 —NH₂ H F H H H OMe OEt OH H H H OMe NH —CH₂CH═CMe₂ I-2335 —NH₂ H F H H H OMe OEt OH H H H OMe NH —(CH₂)₂CHMe₂ I-2336 —NH₂ H F H H H OMe OEt OH H H H OMe NMe Me I-2337 —NH₂ H F H H H OMe OEt OH H H H OMe O —CH₂CH═CMe₂ I-2338 —NH₂ H F H H H OMe OEt OH H H H OMe O —CH₂CH═CCl₂

TABLE 320 I-2339 —NH₂ H F H H H OMe OEt OH H H F H NH —CH₂CH═CMe₂ I-2340 —NH₂ H F H H H OMe OEt OH H H F H NH —(CH₂)₂CHMe₂ I-2341 —NH₂ H F H H H OMe OEt OH H H F H NMe Me I-2342 —NH₂ H F H H H OMe OEt OH H H F H O —CH₂CH═CMe₂ I-2343 —NH₂ H F H H H OMe OEt OH H H F H O —CH₂CH═CCl₂ I-2344 —NH₂ H F H H H OMe OEt OH H H H OEt NH —CH₂CH═CMe₂ I-2345 —NH₂ H F H H H OMe OEt OH H H H OEt NH —(CH₂)₂CHMe₂ I-2346 —NH₂ H F H H H OMe OEt OH H H H OEt NMe Me I-2347 —NH₂ H F H H H OMe OEt OH H H H OEt O —CH₂CH═CMe₂ I-2348 —NH₂ H F H H H OMe OEt OH H H H OEt O —CH₂CH═CCl₂ I-2349 —NHCH₂CH═CMe₂ H H H H Me Me Me H H H H OMe NH —CH₂CH═CMe₂ I-2350 —NHCH₂CH═CMe₂ H H H H Me Me Me H H H H OMe NH —(CH₂)₂CHMe₂ I-2351 —NHCH₂CH═CMe₂ H H H H Me Me Me H H H H OMe NMe Me I-2352 —NHCH₂CH═CMe₂ H H H H Me Me Me H H H H OMe O —CH₂CH═CMe₂ I-2353 —NHCH₂CH═CMe₂ H H H H Me Me Me H H H H OMe O —CH₂CH═CCl₂ I-2354 —NHCH₂CH═CMe₂ H H H H Me Me Me H H H F H NH —CH₂CH═CMe₂ I-2355 —NHCH₂CH═CMe₂ H H H H Me Me Me H H H F H NH —(CH₂)₂CHMe₂ I-2356 —NHCH₂CH═CMe₂ H H H H Me Me Me H H H F H NMe Me I-2357 —NHCH₂CH═CMe₂ H H H H Me Me Me H H H F H O —CH₂CH═CMe₂ I-2358 —NHCH₂CH═CMe₂ H H H H Me Me Me H H H F H O —CH₂CH═CCl₂ I-2359 —NHCH₂CH═CMe₂ H H H H Me Me Me H H H H OEt NH —CH₂CH═CMe₂

TABLE 321 I-2360 —NHCH₂CH═CMe₂ H H H H Me Me Me H H H H OEt NH —(CH₂)₂CHMe₂ I-2361 —NHCH₂CH═CMe₂ H H H H Me Me Me H H H H OEt NMe Me I-2362 —NHCH₂CH═CMe₂ H H H H Me Me Me H H H H OEt O —CH₂CH═CMe₂ I-2363 —NHCH₂CH═CMe₂ H H H H Me Me Me H H H H OEt O —CH₂CH═CCl₂ I-2364 —NHCH₂CH═CMe₂ H H H H H Me OMe OH H H H OMe NH —CH₂CH═CMe₂ I-2365 —NHCH₂CH═CMe₂ H H H H H Me OMe OH H H H OMe NH —(CH₂)₂CHMe₂ I-2366 —NHCH₂CH═CMe₂ H H H H H Me OMe OH H H H OMe NMe Me I-2367 —NHCH₂CH═CMe₂ H H H H H Me OMe OH H H H OMe O —CH₂CH═CMe₂ I-2368 —NHCH₂CH═CMe₂ H H H H H Me OMe OH H H H OMe O —CH₂CH═CCl₂ I-2369 —NHCH₂CH═CMe₂ H H H H H Me OMe OH H H F H NH —CH₂CH═CMe₂ I-2370 —NHCH₂CH═CMe₂ H H H H H Me OMe OH H H F H NH —(CH₂)₂CHMe₂ I-2371 —NHCH₂CH═CMe₂ H H H H H Me OMe OH H H F H NMe Me I-2372 —NHCH₂CH═CMe₂ H H H H H Me OMe OH H H F H O —CH₂CH═CMe₂ I-2373 —NHCH₂CH═CMe₂ H H H H H Me OMe OH H H F H O —CH₂CH═CCl₂ I-2374 —NHCH₂CH═CMe₂ H H H H H Me OMe OH H H H OEt NH —CH₂CH═CMe₂ I-2375 —NHCH₂CH═CMe₂ H H H H H Me OMe OH H H H OEt NH —(CH₂)₂CHMe₂ I-2376 —NHCH₂CH═CMe₂ H H H H H Me OMe OH H H H OEt NMe Me I-2377 —NHCH₂CH═CMe₂ H H H H H Me OMe OH H H H OEt O —CH₂CH═CMe₂ I-2378 —NHCH₂CH═CMe₂ H H H H H Me OMe OH H H H OEt O —CH₂CH═CCl₂ I-2379 —NHCH₂CH═CMe₂ H H H H Me H Me OH H H H OMe NH —CH₂CH═CMe₂ I-2380 —NHCH₂CH═CMe₂ H H H H Me H Me OH H H H OMe NH —(CH₂)₂CHMe₂

TABLE 322 I-2381 —NHCH₂CH═CMe₂ H H H H Me H Me OH H H H OMe NMe Me I-2382 —NHCH₂CH═CMe₂ H H H H Me H Me OH H H H OMe O —CH₂CH═CMe₂ I-2383 —NHCH₂CH═CMe₂ H H H H Me H Me OH H H H OMe O —CH₂CH═CCl₂ I-2384 —NHCH₂CH═CMe₂ H H H H Me H Me OH H H F H NH —CH₂CH═CMe₂ I-2385 —NHCH₂CH═CMe₂ H H H H Me H Me OH H H F H NH —(CH₂)₂CHMe₂ I-236 —NHCH₂CH═CMe₂ H H H H Me H Me OH H H F H NMe Me I-2387 —NHCH₂CH═CMe₂ H H H H Me H Me OH H H F H O —CH₂CH═CMe₂ I-2388 —NHCH₂CH═CMe₂ H H H H Me H Me OH H H F H O —CH₂CH═CCl₂ I-2389 —NHCH₂CH═CMe₂ H H H H Me H Me OH H H H OEt NH —CH₂CH═CMe₂ I-2390 —NHCH₂CH═CMe₂ H H H H Me H Me OH H H H OEt NH —(CH₂)₂CHMe₂ I-2391 —NHCH₂CH═CMe₂ H H H H Me H Me OH H H H OEt NMe Me I-2392 —NHCH₂CH═CMe₂ H H H H Me H Me OH H H H OEt O —CH₂CH═CMe₂ I-2393 —NHCH₂CH═CMe₂ H H H H Me H Me OH H H H OEt O —CH₂CH═CCl₂ I-2394 —NHCH₂CH═CMe₂ H H H H H Me Me Me H H H OMe NH —CH₂CH═CMe₂ I-2395 —NHCH₂CH═CMe₂ H H H H H Me Me Me H H H OMe NH —(CH₂)₂CHMe₂ I-2396 —NHCH₂CH═CMe₂ H H H H H Me Me Me H H H OMe NMe Me I-2397 —NHCH₂CH═CMe₂ H H H H H Me Me Me H H H OMe O —CH₂CH═CMe₂ I-2398 —NHCH₂CH═CMe₂ H H H H H Me Me Me H H H OMe O —CH₂CH═CCl₂ I-2399 —NHCH₂CH═CMe₂ H H H H H Me Me Me H H F H NH —CH₂CH═CMe₂ I-2400 —NHCH₂CH═CMe₂ H H H H H Me Me Me H H F H NH —(CH₂)₂CHMe₂ I-2401 —NHCH₂CH═CMe₂ H H H H H Me Me Me H H F H NMe Me

TABLE 323 I-2402 —NHCH₂CH═CMe₂ H H H H H Me Me Me H H F H O —CH₂CH═CMe₂ I-2403 —NHCH₂CH═CMe₂ H H H H H Me Me Me H H F H O —CH₂CH═CCl₂ I-2404 —NHCH₂CH═CMe₂ H H H H H Me Me Me H H H OEt NH —CH₂CH═CMe₂ I-2405 —NHCH₂CH═CMe₂ H H H H H Me Me Me H H H OEt NH —(CH₂)₂CHMe₂ I-2406 —NHCH₂CH═CMe₂ H H H H H Me Me Me H H H OEt NMe Me I-2407 —NHCH₂CH═CMe₂ H H H H H Me Me Me H H H OEt O —CH₂CH═CMe₂ I-2408 —NHCH₂CH═CMe₂ H H H H H Me Me Me H H H OEt O —CH₂CH═CCl₂ I-2409 —NHCH₂CH═CMe₂ H H H H H OMe OEt OH H H H OMe NH —CH₂CH═CMe₂ I-2410 —NHCH₂CH═CMe₂ H H H H H OMe OEt OH H H H OMe NH —(CH₂)₂CHMe₂ I-2411 —NHCH₂CH═CMe₂ H H H H H OMe OEt OH H H H OMe NMe Me I-2412 —NHCH₂CH═CMe₂ H H H H H OMe OEt OH H H H OMe O —CH₂CH═CMe₂ I-2413 —NHCH₂CH═CMe₂ H H H H H OMe OEt OH H H H OMe O —CH₂CH═CCl₂ I-2414 —NHCH₂CH═CMe₂ H H H H H OMe OEt OH H H F H NH —CH₂CH═CMe₂ I-2415 —NHCH₂CH═CMe₂ H H H H H OMe OEt OH H H F H NH —(CH₂)₂CHMe₂ I-2416 —NHCH₂CH═CMe₂ H H H H H OMe OEt OH H H F H NMe Me I-2417 —NHCH₂CH═CMe₂ H H H H H OMe OEt OH H H F H O —CH₂CH═CMe₂ I-2418 —NHCH₂CH═CMe₂ H H H H H OMe OEt OH H H F H O —CH₂CH═CCl₂ I-2419 —NHCH₂CH═CMe₂ H H H H H OMe OEt OH H H H OEt NH —CH₂CH═CMe₂ I-2420 —NHCH₂CH═CMe₂ H H H H H OMe OEt OH H H H OEt NH —(CH₂)₂CHMe₂ I-2421 —NHCH₂CH═CMe₂ H H H H H OMe OEt OH H H H OEt NMe Me I-2422 —NHCH₂CH═CMe₂ H H H H H OMe OEt OH H H H OEt O —CH₂CH═CMe₂

TABLE 324 I-2423 —NHCH₂CH═CMe₂ H H H H H OMe OEt OH H H H OEt O —CH₂CH═CCl₂ I-2424 —OMe H H H H Me Me Me H H H H OMe NH —CH₂CH═CMe₂ I-2425 —OMe H H H H Me Me Me H H H H OMe NH —(CH₂)₂CHMe₂ I-2426 —OMe H H H H Me Me Me H H H H OMe NMe Me I-2427 —OMe H H H H Me Me Me H H H H OMe O —CH₂CH═CMe₂ I-2428 —OMe H H H H Me Me Me H H H H OMe O —CH₂CH═CCl₂ I-2429 —OMe H H H H Me Me Me H H H F H NH —CH₂CH═CMe₂ I-2430 —OMe H H H H Me Me Me H H H F H NH —(CH₂)₂CHMe₂ I-2431 —OMe H H H H Me Me Me H H H F H NMe Me I-2432 —OMe H H H H Me Me Me H H H F H O —CH₂CH═CMe₂ I-2433 —OMe H H H H Me Me Me H H H F H O —CH₂CH═CCl₂ I-2434 —OMe H H H H Me Me Me H H H H OEt NH —CH₂CH═CMe₂ I-2435 —OMe H H H H Me Me Me H H H H OEt NH —(CH₂)₂CHMe₂ I-2436 —OMe H H H H Me Me Me H H H H OEt NMe Me I-2437 —OMe H H H H Me Me Me H H H H OEt O —CH₂CH═CMe₂ I-2438 —OMe H H H H Me Me Me H H H H OEt O —CH₂CH═CCl₂ I-2439 —OMe H H H H H Me OMe OH H H H OMe NH —CH₂CH═CMe₂ I-2440 —OMe H H H H H Me OMe OH H H H OMe NH —(CH₂)₂CHMe₂ I-2441 —OMe H H H H H Me OMe OH H H H OMe NMe Me I-2442 —OMe H H H H H Me OMe OH H H H OMe O —CH₂CH═CMe₂ I-2443 —OMe H H H H H Me OMe OH H H H OMe O —CH₂CH═CCl₂

TABLE 325 I-2444 —OMe H H H H H Me OMe OH H H F H NH —CH₂CH═CMe₂ I-2445 —OMe H H H H H Me OMe OH H H F H NH —(CH₂)₂CHMe₂ I-2446 —OMe H H H H H Me OMe OH H H F H NMe Me I-2447 —OMe H H H H H Me OMe OH H H F H O —CH₂CH═CMe₂ I-2448 —OMe H H H H H Me OMe OH H H F H O —CH₂CH═CCl₂ I-2449 —OMe H H H H H Me OMe OH H H H OEt NH —CH₂CH═CMe₂ I-2450 —OMe H H H H H Me OMe OH H H H OEt NH —(CH₂)₂CHMe₂ I-2451 —OMe H H H H H Me OMe OH H H H OEt NMe Me I-2452 —OMe H H H H H Me OMe OH H H H OEt O —CH₂CH═CMe₂ I-2453 —OMe H H H H H Me OMe OH H H H OEt O —CH₂CH═CCl₂ I-2454 —OMe H H H H Me H Me OH H H H OMe NH —CH₂CH═CMe₂ I-2455 —OMe H H H H Me H Me OH H H H OMe NH —(CH₂)₂CHMe₂ I-2456 —OMe H H H H Me H Me OH H H H OMe NMe Me I-2457 —OMe H H H H Me H Me OH H H H OMe O —CH₂CH═CMe₂ I-2458 —OMe H H H H Me H Me OH H H H OMe O —CH₂CH═CCl₂ I-2459 —OMe H H H H Me H Me OH H H F H NH —CH₂CH═CMe₂ I-2460 —OMe H H H H Me H Me OH H H F H NH —(CH₂)₂CHMe₂ I-2461 —OMe H H H H Me H Me OH H H F H NMe Me I-2462 —OMe H H H H Me H Me OH H H F H O —CH₂CH═CMe₂ I-2463 —OMe H H H H Me H Me OH H H F H O —CH₂CH═CCl₂ I-2464 —OMe H H H H Me H Me OH H H H OEt NH —CH₂CH═CMe₂

TABLE 326 I-2465 —OMe H H H H Me H Me OH H H H OEt NH -(CH₂)₂CHMe2 I-2466 —OMe H H H H Me H Me OH H H H OEt NMe Me I-2467 —OMe H H H H Me H Me OH H H H OEt O —CH₂CH═CMe2 I-2468 —OMe H H H H Me H Me OH H H H OEt O —CH₂CH═CCl₂ I-2469 —OMe H H H H H Me Me Me H H H OMe NH —CH₂CH═CMe₂ I-2470 —OMe H H H H H Me Me Me H H H OMe NH —(CH₂)₂CHMe₂ I-2471 —OMe H H H H H Me Me Me H H H OMe NMe Me I-2472 —OMe H H H H H Me Me Me H H H OMe O —CH₂CH═CMe₂ I-2473 —OMe H H H H H Me Me Me H H H OMe O —CH₂CH═CCl₂ I-2474 —OMe H H H H H Me Me Me H H F H NH —CH₂CH═CMe₂ I-2475 —OMe H H H H H Me Me Me H H F H NH —(CH₂)₂CHMe₂ I-2476 —OMe H H H H H Me Me Me H H F H NMe Me I-2477 —OMe H H H H H Me Me Me H H F H O CH₂CH═CMe₂ I-2478 —OMe H H H H H Me Me Me H H F H O —CH₂CH═CCl₂ I-2479 —OMe H H H H H Me Me Me H H H OEt NH —CH₂CH═CMe₂ I-2480 —OMe H H H H H Me Me Me H H H OEt NH —(CH₂)₂CHMe₂ I-2481 —OMe H H H H H Me Me Me H H H OEt NMe Me I-2482 —OMe H H H H H Me Me Me H H H OEt O —CH₂CH═CMe₂ I-2483 —OMe H H H H H Me Me Me H H H OEt O —CH₂CH═CCl₂ I-2484 —OMe H H H H H OMe OEt OH H H H OMe NH —CH₂CH═CMe₂ I-2485 —OMe H H H H H OMe OEt OH H H H OMe NH —(CH₂)₂CHMe₂

TABLE 327 I-2486 —OMe H H H H H OMe OEt OH H H H OMe NMe Me I-2487 —OMe H H H H H OMe OEt OH H H H OMe O —CH₂CH═CMe₂ I-2488 —OMe H H H H H OMe OEt OH H H H OMe O —CH₂CH═CCl₂ I-2489 —OMe H H H H H OMe OEt OH H H F H NH —CH₂CH═CMe₂ I-2490 —OMe H H H H H OMe OEt OH H H F H NH —(CH₂)₂CHMe₂ I-2491 —OMe H H H H H OMe OEt OH H H F H NMe Me I-2492 —OMe H H H H H OMe OEt OH H H F H O —CH₂CH═CMe₂ I-2493 —OMe H H H H H OMe OEt OH H H F H O —CH₂CH═CCl₂ I-2494 —OMe H H H H H OMe OEt OH H H H OEt NH —CH₂CH═CMe₂ I-2495 —OMe H H H H H OMe OEt OH H H H OEt NH —(CH₂)₂CHMe₂ I-2496 —OMe H H H H H OMe OEt OH H H H OEt NMe Me I-2497 —OMe H H H H H OMe OEt OH H H H OEt O —CH₂CH═CMe₂ I-2498 —OMe H H H H H OMe OEt OH H H H OEt O —CH₂CH═CCl₂

In the above tables, “—OCH₂O—*” and “*” mean that they taken together form a ring.

Experiment 1 Suppressive Effect on a Mitogenic Activity of Mouse Splenocytes In Vitro

In 96-well microtiter plate 5×10⁵ C3H/HeN mouse splenocytes suspended in 0.1 ml of 10% fetal bovine serum-fortified RPMI 1640 medium containing 2 mM of sodium bicarbonate, 50 units/ml of penicillin, 50 μg/ml of streptomycin and 5×10⁻⁵ M of 2-mercaptoethanol were added. Then, 5 μg/ml of Concanavalin A (Con A) or 10 μg/ml of lipopolysaccharide (LPS) as a mitogen and the compound of a pre-determined concentration of the present invention were added to each well so that a final volume of each well reached 0.2 ml. Each compound of the present invention was dissolved in dimethylsulfoxide (DMSO) and diluted with the above RPMI 1640 medium to adjust the final concentration of 100 ng/ml or less. The splenocytes in the 96-well microtiter plate were cultivated at 37° C. for 3 days in an incubator keeping the humidity 100%, carbon dioxide 5% and air 95%. Then, 25 μl of 6 mg/ml MTT [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide] (Sigma) was added to the each well and cultivated at 37° C. for 4 hours under the same conditions. After the cultivation, 50 μl of 0.02 N hydrochloric acid in 20% sodium dodecyl sulfate (SDS) was added to formazan generated and left at 37° C. for 24 hours for dissolving formazan. An absorption intensity (OD) of formazan generated in proportion to the number of living cells was measured with an immunoreader (InterMed) equipped with a 570 nm filter (The Journal of Immunological Method, 65, 55–63, 1983). The 50% inhibitory concentration of a cell proliferation (IC ₅₀) was calculated from a correlation between the concentration of the compound of the present invention and the absorption intensity.

Experiment 2 Anti-proliferative Activity on EL4 Cells

In 96-well microtiter plate 4×10⁴/0.1 ml of mouse thymoma strain EL4 cells were added and 0.1 ml of the compound of the present invention was added to the mixture so that the concentration was in the range of 0–5,000 ng/ml. After the cultivation for 3 days, the IC₅₀ was calculated by the MTT method as described in Experiment 1.

The results are shown in Tables 328–329.

TABLE 328 ConA LPS EL-4 IC₅₀ IC₅₀ IC₅₀ Compound (ng/ml) (ng/ml) (ngl/ml) I-1 0.86 1.92 8.56 I-9 <20 <20 <20 I-12 1.3 2.8 46.2 I-22 5.62 4.26 6.2 I-35 19.5 39.4 140 I-40 6.1 16.5 37.4 I-41 0.73 1.74 4.89 I-46 10.6 23.9 67.5 I-49 8.89 16.2 31.7 I-50 3.83 9.2 11.9 I-51 6.6 14.7 70.0 I-59 8.5 22.4 140 I-62 29.2 25 23.4 I-63 13 27 16 I-66 0.22 0.35 0.48 I-71 4.56 14.2 31.2 I-101 0.8 0.5 1.8 I-103 3.4 3.7 4.6 I-104 3.0 3.1 4.8 I-106 0.6 0.4 2.7 I-107 0.6 0.7 12 I-121 0.8 1.2 0.8 I-163 <20 <20 <20 I-173 <20 <20 <20 I-175 <20 29.4 <20 I-187 12.0 25.1 36.2 I-211 <20 <20 <20 I-248 <10 <10 312 I-250 <10 <10 88.3 I-251 <10 <10 97.4 I-255 <20 <20 <20 I-256 <20 28.7 310 I-275 6.34 13.5 100 I-276 1.8 3.1 200 I-299 5.53 7.85 13.6 I-301 7.06 11.0 15.8 I-360 <20 <20 99.8 I-361 <20 <20 124 I-418 255 497 >10000 I-427 255 497 >10000 I-457 <20 <20 205 I-466 <20 <20 46 I-484 14.7 32.2 91.4 I-513 6.89 11.1 61.8 I-525 0.76 1.11 5.0 I-639 4.59 6.25 50 I-661 0.67 1.28 50 I-739 18.8 20.7 430 I-742 10 20 45.2 I-758 6.78 9.63 55.1 I-773 8.45 12.6 92.9 I-797 1.75 3.71 26.5 I-834 36 46 226 I-839 1.48 1.87 20.7 I-840 5.31 6.94 31.9 I-878 14.1 27.4 194 I-880 23.0 41.1 105 I-892 <0.2 <0.2 1.41 I-893 0.49 1.05 7.06

TABLE 329 ConA LPS EL-4 IC₅₀ IC₅₀ IC₅₀ Compound (ng/ml) (ng/ml) (ng/ml) I-907 23.4 44.5 82.7 I-908 0.45 0.86 3.50 I-909 <20 <20 20 I-931 2.93 5.76 4.37 I-934 16.1 22.2 52.7 I-943 2.97 4.89 46.8 I-962 12.1 16.3 20.4 I-970 <20 <20 50.3 I-976 17.7 34.2 330 I-981 14.9 27.1 >100 I-982 2.0 3.75 55.3 I-988 0.2 0.31 1.23 I-993 5.10 7.54 13.8 I-995 20.9 25.2 49.2 I-1006 8.66 12.3 33.0 I-1007 8.05 10.4 13.1 I-1017 9.74 16.7 72.9 I-1031 <20 21.2 41.7 I-1040 1.80 5.31 1.85 I-1043 2.19 3.27 9.70 I-1058 21.2 30.2 48.8 I-1066 3.91 4.87 20.6 I-1095 6.90 9.57 34.2 I-1103 4.7 6.9 31.4 I-1107 5.8 9.1 34.1 I-1115 <20 <20 <20 I-1121 3.12 9.0 18.6 I-1123 0.80 2.00 3.9 I-1124 94 272 >10000 I-1126 79 234 >10000 I-1127 44 111 412 I-1128 5.00 11.4 26.0 I-1135 1.00 2.70 11.7 I-1160 10.6 14.1 97.4 I-1161 2.4 4.2 33.2 I-1162 0.65 1.95 30.9 I-1167 0.08 0.23 8.1 I-1168 0.26 0.54 12.5 I-1171 0.63 0.64 27.5 I-1172 13.1 19.4 >100 I-1173 16.4 31.1 >100 I-1177 12.2 20.8 47.2 I-1191 0.16 0.66 22.8 I-1193 1.46 5.3 50 I-1203 14.1 >100 43.5 I-1212 12.87 24.2 85.0 I-1217 <20 <20 <20 I-1227 197 423 >10000 I-1229 5.95 8.05 20.4 I-1230 12.0 15.3 5.22 I-1232 3.77 4.93 15.1 I-1240 2.50 3.34 11.8 I-1248 25.9 36.8 118 I-1250 0.68 1.35 2.90 I-1251 6.30 10.7 27.8 I-1263 <20 <20 29.8 I-1271 0.10 0.32 1.66 I-1274 0.33 1.38 1.44 I-1276 <20 31.3 105 I-1277 <20 <20 <20 I-1278 <20 <20 41.7 I-1284 <20 <20 <20 I-1286 <20 <20 <20 I-1289 <20 <20 <20 I-1290 <20 <20 27.3 I-1295 <20 <20 <20 I-1296 <20 <20 39.7

As shown in the above, the compound of the present invention has immunosuppressive and anti-allergic effects.

Experiment 3 Suppressive Effect on the Antibody Production Against bovine γ Globulin (BGG)

On an immunizing day and 7 days after, 50 μg of BGG was subcutaneously inoculated to backs of BALB/c mice (male, 6–8 weeks old) for inducing an immune reaction. After the compound of the present invention was dissolved or suspended in N,N-dimethylacetoamide, the mixture was diluted with miglyol 812 neutral oil. A proper volume of the compound was orally administered (p.o.) to mice every day from the next day of the immunizing. A two hundredth weight to body weight of miglyol was administered to mice in a control group. After 21 days, blood was drawn from each mouse and a serum was separated. BGG-specific IgE in a serum was measured by the sandwich ELISA method using a BGG-coating plate. The suppressive rate of IgE production was calculated from the dilution rate of the serum which has the same absorption intensity as that of the control group for judging the effect of the compound of the present invention. The results are shown in Table 330.

TABLE 330 Suppressive rate of Dose antigen-specific IgE Compound (mg/kg) (%) I-525 100 >95 I-915 100 >99 I-892 5 >99 I-963 50 >99 I-1031 100 >99 I-1093 100 >99

Experiment 4 Suppressive Effect on the IgE Production Against Ovalbumin (OVA)

1) Animals

BALB/c mice (female, 8–10 weeks old) and Wistar rats (female, 8–10 weeks old) which were bought from Japan SLC, Inc. (Shizuoka) were used.

2) Immunizing Method

BALB/c mice were immunized by an intraperitoneal administration of 0.2 ml suspension of 2 μg of ovalbumin (OVA) and 2 mg of aluminium hydroxide gel in physiological saline. After 10 days, blood was drawn from hearts, sera were separated and stocked at −40° C. till the measurement of an IgE antibody titer.

3) Compounds

After the compound of the present invention was dissolved or suspended in N,N-dimethylacetoamide, the mixture was diluted 20 times with miglyol 812 neutral oil. The obtained solution was orally administered to mice at 0.1 ml per mouse. The administration was continued for 10 days from the immunizing day to the day before drawing blood. IPD-1151-T (a compound described in Jpn. Pharmacol. (1993) 61, 31–39) and a compound No. 36 (a compound 36 described in J. Med. Chem. (1997) 40: 395–407) were examined as controls by the same method.

4) Measurement of Anti-OVA IgE Antibody Titer (PCA Titer)

The samples 2-fold diluted with physiological saline were prepared from the obtained mouse serum and each 50 μl of the solution was intradermauy injected to backs of Wistar rats which previously hair cut. After 24 hours, a passive cutaneous anaphylaxis reaction (PCA) was induced by an intravenous injection of 0.5 ml of physiological saline containing 1 mg of OVA and 5 mg of Evans' blue dye. After 30 minutes, the rats were sacrified and the highest dilution rate of the serum giving bluing with a diameter of more than 5 mm was recorded as the PCA titer. For example, when a serum is positive for the PCA reaction till 2⁷ times dilution, the anti-OVA IgE antibody titer of the mouse is defined as 7. The results are shown in Table 331.

TABLE 331 Dose Compound (mg/kg) PCA Titer I-484 40 <0 I-839 40 2.4** I-851 40 1.8** I-892 40 <0 I-893 40 2.5** I-908 40 3.4** I-915 40 <0 I-925 40   1** I-928 40 <0 I-948 40 2.6** I-957 40 4.5** I-962 40 <0 I-963 40 3.6** I-988 40 0.8** I-1031 40 4.4** I-1043 40 4.8** I-1066 40 <0 I-1072 40 0.8** I-1095 40 <0 I-1123 40 2.4** I-1135 40 4.8** I-1167 40 4.4** I-1171 40 <0 I-1177 40 3.6** I-1229 40 <0 I-1232 40 1.8** I-1242 40 2.8** I-1258 40 1.2** I-1271 40 <0 IPD-1151-T 50  9.8 No. 36 10  10.4 **P < 0.01 vs vehicle

The PCA titers of mice in a group to which any compound was not administered were 9–12.

IPD-1151-T . . .

As shown in the above, the compound of the present invention has a suppressive effect on the antibody production.

Experiment 5 Suppressive Effect on the Antibody Production of Human Lymphocytes

1. Experimental Method

-   1) Human Peripheral Blood

Human peripheral blood was drawn from healthy male adults by plastic syringes filled with heparin (final concentration 1.5%). Lymphocytes were collected immediately after blood was drawn.

-   2) Medium

RPMI medium (Nissui Pharmaceutical Co., Ltd.) containing 10% fetal bovine serum (HyClone Lab.) inactivated at 56° C. for 30 minutes, penicillin (100 units/ml) and streptomycin (100 μg/ml) (GIBCO) was used.

-   3) Compounds

After the compound (I-839) of the present invention was dissolved in dimethylsulfoxide (Nakaraitesk) at 2 μg/ml, the solution was diluted with the medium to adjust a final concentration to be 0.01 pg/ml–10 μg/ml. The compound No. 36 was examined as a control by the same method.

-   4) Human Lymphocytes

Human peripheral blood was stratified in a tube filled with Ficoll-Hypaque mixture solution (Dainippon Pharmaceutical Co., Ltd. (Osaka), Mono-poly resolving medium) at the same volume and centrifuged at 300×g at 15° C. for 30 minutes to obtain a lymphocytes layer. After the collected cell suspension was washed with sterile Hanks' solution (Nissui Pharmaceutical Co., Ltd.) by centrifugation, sterile distilled water was added to the suspension. After 30 seconds, twice-concentrated Hanks' solution of which amount is equal to the water was added for removal of contaminating erythrocytes. Lymphocytes which were filtered by a nylon mesh and washed by centrifugation were used for experiments as human lymphocytes.

-   5) Induction of the IgE Antibody Production by Stimulation of B     Cells

In 96-well cultivating plate (Sumitomo bakelite) the lymphocytes were inoculated 2×10⁵ cells per well, and the compound, anti-human CD 40 antigen (Pharmingen, 2 μg/ml), human recombinant interleukin-4 (IL-4) (Genzyme, 0.1 μg/ml) and human recombinant interleukin-10 (IL-10) (Genzyme, 0.2 μg/ml) were added and cultivated at 37° C. under 5% of CO₂ (0.2 ml!well). After the cultivation for 10 days, the amount of antibody in a supernatant was quantified by ELISA method.

-   6) Quantification of the IgE Antibody

A commercial kit MESACUP IgE test (Medical & Biological Laboratories Co., Ltd.) was used for the quantification of the IgE. The experiment followed an instruction manual and was carried out in triplicate to calculate the average.

-   7) Quantification of the IgG and IgM Antibodies

ELISA method was used for the quantification. In 96-well plate (Nunc) 50 μl of 1 μg/ml F(ab′)₂ Goat Anti-human IgG+A+M (H+L) (ZYMED Laboratories) was added and the plate was coated at 4° C. overnight. The,plate was washed twice with 0.05% Tween/PBS (PBST) solution and 100 μl of 0.5% gelatin/PBST was added for blocking at room temperature for 2 hours. After washing three times with PBST, 100 μl of a sample diluted with PBS or 100 μl of human Plasma IgG standard solution or IgM standard solution (BioPur AG, Switzerland) of a pre-determined concentration was added and incubated at room temperature for 1 hour. After washing three times with PBST, 100 μl of a peroxydase-labeled anti-human IgG antibody or anti-human IgM antibody (Southern Biotechnology, Birmingham) which was diluted two thousandth with PBS was added and incubated at room temperature for 1 hour. After washing four times with PBST, 100 μl of a substrate, o-phenylenediamine dihydrochloride, was added for color development. After 30 minutes, the reaction was terminated by addition of 50 μl of 2 N HCl, and the absorption at 492 nm was measured with a microplate reader and the amount of the IgG and IgM was calculated from a standard curve of a standard solution.

2. Results

The results are shown in FIGS. 1 and 2. The compound (1–839) of the present invention has a selective suppressive effect on the IgE antibody production and the intensity was 2,000 times or more of that of the IgG production and 30,000 times or more of that of the IgM. The suppressive effects of the typical compounds on the antibody production are shown in Table 332.

TABLE 332 IC₅₀ (ng/ml) Compound IgE IgG IgM I-839 <0.00001 0.027 0.37 I-892 <0.00001 <0.00001 >1 I-121 <0.0001 <0.0001 >1 I-988 <0.00001 <0.00001 >1 I-893 <0.00001 <0.0001 >1

Experiment 6 Suppressive Effect on Antibody Production of Mouse Spleen Lymphocytes

1. Experimental Method

-   1) Animals

BALB/c (nu/nu) mice were bought from Japan SLC, Inc. (Shizuoka) and 7 weeks old-male mice were used.

-   2) Medium RPMI medium (Nissui Pharmaceutical Co., Ltd.) containing     10% fetal bovine serum (HyClone Lab.) inactivated at 56° C. for 30     minutes, penicillin (100 units/ml) and streptomycin (100 μg/ml)     (GIBCO) was used for experiments. -   3) Compounds

Each of the compounds was dissolved in dimethylsulfoxide (Nakaraitesk) at 2 μg/ml and diluted with the medium to adjust a final concentration to 0.1 pg/ml–10 μg/ml.

-   4) Mouse Spleen Lymphocytes

A spleen of mouse was taken out and put in a cultivating schale which was filled with Hanks' solution. The spleen was crushed and the cells were pushed out from the organ and filtered through a metal mesh (200 mesh). After the collected cell suspension was washed by centrifugation with sterile Hanks' solution (Nissui Pharmaceutical Co., Ltd.), sterile distilled water was added. After 30 seconds, an equal amount of twice-concentrated Hanks' solution was added for removal of contaminating erythrocytes. The cell suspension, filtered by a nylon mesh and washed by centrifugation, were used as mouse spleen lymphocytes for experiments.

-   5) Induction of the IgE Antibody Production by the B Cell     Stimulation

In 96-well cultivating plate (Sumitomo Bakelite Company Limited) mouse spleen lymphocytes were inoculated 2×10⁵ cells per well. The compound of the present invention, lipopolysaccharide (DIFCO Lab., 2 μg/ml) and mouse recombinant interleukin-4 (IL-4) (Genzyme, 50 ng/ml) were added to the well and cultivated at 37° C. under 5% CO₂ (0.2 ml/well). After the cultivation for 10 days, the amount of the antibody in a supernatant was quantified by ELISA method.

-   6) Quantification of the IgE Antibody

A commercial mouse IgE EIA kit (Yamasa Shoyu Co., Ltd.) was used for the quantification of the IgE. The experiment followed an instruction manual and was carried out in triplicate to calculate the average.

-   7) Quantification of the IgG1, IgG2a and IgM Antibodies

In 96-well plate 50 μl of 10 μg/ml Goat Anti-Mouse Ig (IgM+G+A, H+L) (Southern Biotechnology, Birmingham) was added and the plate was coated at 4° C. overnight. After the plate was washed twice with a PBST solution, 100 μl of 0.5% gelatin/PBST was added and the plate was blocked at room temperature for 2 hours. After washing three times with PBST, 100 μl of culture supernatant which was diluted with PBS or 100 μl of an antibody standard solution (Mouse IgG1 standard, Mouse IgG2a standard, Mouse IgM standard, BETHYL Laboratories) of a pre-determined concentration was added and incubated for 1 hour. After washing three times with PBST, 100 μl of diluted solution of alkalinephosphatase-labeled anti-mouse IgG1, IgG2a or IgM antibody (Southern Biotechnology, Birmingham) was added and incubated at room temperature for 1 hour. After washing four times with PBST, a substrate, p-nitrophenyl phosphate disodium, was added, and after 30 minutes-incubation period, after 5 N—NaOH was added to stop the reaction. The absorption at 405 nm was measured with a microplate reader, and the amount of the antibody was calculated from the standard curve. For the dilution of the mouse sample and the standard solution was used 10% FCS/PBS.

2. Results

The results are shown in FIG. 3. The figure shows that the compound (I-967) has a suppressive effect on the IgG1, IgG2a and IgM antibodies production only at 1000 ng/ml or more but has a dose-dependent suppressive effect on the IgE production at 0.01 ng/ml or more. In Table 333 the suppressive effects of the representative compounds on the IgE, IgM, IgG1 and IgG2a production are shown.

TABLE 333 IC₅₀ (ng/ml) Compound IgE IgG1 IgG2a IgM I-73 0.044 2600 4900 4200 I-963 0.00026 510 3600 3500 I-967 0.1 3500 3600 >10000

Experiment 7 Suppressive Effect on Bronchial Inflammatory Cell Infiltration by Inhalation of Antigen

1. Experimental Method

-   1) Animals

BALB/c mice bought from Japan SLC, Inc. (Shizuoka) (female, 8–11 weeks old) were used for experiments.

-   2) Sensitizing and Challenge of Antigen

For immunizing, 0.2 ml of a suspension of 2 μg of ovalbumin (OVA; Grade V, SIGMA) and 2 mg of aluminium hydroxide gel in physiological saline was intraperitoneally injected. After 2 weeks, 0.2 ml of a solution of 2 μg of OVA in physiological saline was intraperitoneally injected for a booster. After 1 week, each of mice was put in a nebulizing container (an airtight polycarbonate container, 24.5 cm in inner diameter and 20 cm in effective inner height, equipped with 12 cylindrical tubes of 4.8 cm in inner diameter and 12 cm in height) and made inhale a solution of 5% ovalbumin (Grade III, SIGMA) in physiological saline for 20 minutes with an ultrasonic neblizer (Omron Tateisi Elec-Tronics co., NE-U12) for the challenge of antigen.

-   3) Administration of the Compound of the Present Invention

The compound (I-963) of the present invention was dissolved in N,N-dimethylacetoamide (Nakaraitesk) and diluted one twentieth with miglyol 812 neutral oil (Mitsuba Trading Co., Ltd.) and the solution was orally administered to mice at 40 mg/kg. The administration was continued for 9 days from the booster day to the day before broncho-alveolar lavage.

-   4) Broncho-alveolar Lavage (BAL)

After 48 hours of the challenge of antigen, the mice were exsanguinated from hearts under ether anesthetic, and the trachea was then cannulated. 0.3 ml of PBS were injected into the lungs and collected, and reinjected four times more (total 1.5 ml).

-   5) Measurement of the Total Cell Number in BAL Solution and     Classification of Inflammatory Cells

After calculation of the total cell number by coloring of a part of BAL solution with Tuirk solution, cells in BAL solution were put on a slide glass with cytospin (SHANDON) for May-Grüwald-Giemsa (MERCK) staining. Under a microscope, 500 cells were classified to a macrophage, an eosinophil, a neutrophil and a lymphocyte and a proportion of each type of the cells was calculated. The number of each type of the cells was calculated by a multiplication of its proportion and the total cell number.

2. Results

The results are shown in FIG. 4. As shown in the figure, the compound (I-963) of the present invention significantly suppresses increasing number of eosinophils and neutrophils by the challenge of antigen.

Experiment 8 Suppressive Effect on the Cytokine Production of a Mouse T Cell Strain EL-4

In 48-well plate were added 2×10⁵ mouse T cell strain EL-4 which were suspended in 0.2 ml of 1% fetal bovine serum-added RPMI 1640 medium (2 mM of sodium bicarbonate, 50 units/ml of penicillin, 50 μg/ml of streptomycin and 5×10⁻⁵ M of 2-mercaptoethanol were added) and the compound of the present invention of a pre-determined concentration. TPA was added as a cell stimulater at a final concentration of 10 ng/ml to adjust a final volume of each well to 0.4 ml. Each compound of the present invention was dissolved in DMSO and diluted with the above RPMI 1640 medium, and then for added at a final concentration of 100 ng/ml or less. The cells in the 48-well plate were cultivated in an incubator keeping the humidity 100%, carbon dioxide 5% and air 95% at 37° C. for 24 hours to collect a supernatant of each well. The amount of IL-2, IL-4 and IL-5 released in the medium of each well were measured with the ELISA kit (Amersham K. K.) to be taken as an index of the cytokine production of the cells. TPA free group (-TPA) was used as a control. The results are shown in Table 334.

TABLE 334 IC₅₀ (ng/ml) Compound IL-2 IL-4 IL-5 I-4 >500 14 120 I-37 >500 7 110 I-39 1300 7 130 I-70 >2000 0.2 1000 I-73 500 20 15 I-83 >10000 140 1000 I-128 >10000 140 450 I-148 >10000 100 11000 I-157 >10000 170 >10000 I-189 >10000 100 10000 I-190 >100 7 10 I-202 >2000 <20 <20 I-209 >200 14 12 I-213 >1000 25 23 I-218 >1000 4.8 30 I-220 >1000 150 720 I-223 1000 16 45 I-226 880 17 300 I-228 >1000 21 30 I-229 >1000 42 80 I-230 >1000 13 20 I-231 >500 9.6 9.2 I-233 >1000 12 3.8 I-237 >100 17 100 I-238 >1000 35 >1000 I-239 >1000 54 900 I-242 >1000 100 880 I-243 >500 63 >550 I-279 >1000 38 90 I-282 >500 <5 130 I-292 >1000 72 600 I-296 >1000 70 47 I-301 500 <10 120 I-302 >1000 25 280 I-305 >1000 10 340 I-307 >1000 52 23 I-309 >500 29 10 I-318 >1000 68 58 I-323 >1000 230 24 I-368 >1000 72 380 I-375 >1000 200 >1000 I-379 >1000 88 >1000 I-386 >1000 68 40 I-387 >1000 75 40 I-390 >1000 200 160 I-392 >1000 50 >1000 I-395 >1000 1–10 >1000 I-403 >1000 13 >1000 I-720 >500 6 110

Formulation Example 1

The compound of the present invention 15 mg Starch 15 mg Lactose 15 mg Crystalline cellulose 19 mg Polyvinyl alcohol 3 mg Distilled water 30 ml Calcium stearate 3 mg

After all of the above ingredients except for calcium stearate were uniformly mixed, the mixture was crushed and granulated, and dried to obtain a suitable size of granules. After calcium stearate was added to the granules, tablets were formed by compression molding.

INDUSTRIAL APPLICABILITY

As indicated in the above experiments, the compound of the present invention has a potent immunosuppressive and/or anti-allergic activity. The compound of the present invention and a substance which has the same activity as the compound of the present invention are very useful for a selective suppressor of the IgE production, an immunosuppressive agent and/or an anti-allergic agent. 

1. An anti-allergic agent comprising the compound of the formula (I″)

wherein R¹, R², R³, R⁴, R⁵, R⁶, R⁷, R⁸, R⁹, R¹⁰, R¹¹, R¹² and R¹³ are each independently hydrogen, hydroxy, halogen, carboxy, optionally substituted lower alkyl optionally substituted, lower alkoxy, optionally substituted lower alkenyl, optionally substituted lower alkenyloxy, optionally substituted lower alkylthio, optionally substituted lower alkoxycarbonyl, optionally substituted acyloxy, optionally substituted lower alkylsulfonyl, optionally substituted lower alkylsulfonyloxy, optionally substituted lower alkylsulfinyl, nitro, cyano, formyl, optionally substituted amino, optionally substituted carbamoyl, optionally substituted sulfamoyl or optionally substituted heterocyclyl, X is —O—, —CH₂—, —NR¹⁴— wherein R¹⁴ is hydrogen, optionally substituted lower alkyl, optionally substituted lower alkenyl or acetyl, or —S(O)p- wherein p is an integer of 0 to 2, Y is optionally substituted lower alkyl, optionally substituted lower alkenyl, optionally substituted lower alkynyl, optionally substituted acyl, optionally substituted cycloalkyl, optionally substituted cycloalkenyl, optionally substituted aryl or optionally substituted heterocyclyl, and Y may optionally be substituted lower alkoxy when X is —CH₂— and may optionally be substituted lower alkoxycarbonyl, optionally substituted lower alkylsulfonyl or optionally substituted arylsulfonyl when X is —O— or —NR¹⁴—, R¹ and R⁴, R¹ and R², R² and R³, R⁴ and R⁵, R⁶ and R⁷, R⁸ and R⁹, R¹⁰ and R¹¹, R¹² and R¹³, R¹¹ and —X—Y, or R¹³ and —X—Y taken together may form a 5- or 6-membered ring which may contain one or more of O, S or NR¹⁵ wherein R¹⁵ is hydrogen, optionally substituted lower alkyl, optionally substituted lower alkenyl or optionally substituted arylsulfonyl and which may optionally be substituted, excluding a compound of the formula (I′):

wherein R^(1′) is hydrogen or hydroxy and R^(13′) is hydroxy or methoxy; or a pharmaceutically acceptable salt or hydrate thereof, and a pharmaceutically acceptable excipient. 